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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXB3

Z-value: 1.06

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Transcription factors associated with HOXB3

Gene Symbol	Gene ID	Gene Info
HOXB3 Ensembl NCBI GeneCards UniProt	ENSG00000120093.7	HOXB3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXB3	chr17_46643320_46643471	7990	0.072051	0.77	1.6e-02	Click!
HOXB3	chr17_46650833_46651193	372	0.674742	0.59	9.8e-02	Click!
HOXB3	chr17_46633195_46633347	612	0.441121	-0.52	1.5e-01	Click!
HOXB3	chr17_46665362_46665513	2160	0.112807	-0.51	1.6e-01	Click!
HOXB3	chr17_46653822_46653973	1459	0.174654	-0.47	2.0e-01	Click!

Activity of the HOXB3 motif across conditions

Conditions sorted by the z-value of the HOXB3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_64864648_64864996	0.52	SERTAD2	SERTA domain containing 2	16225	0.22
chr11_128582862_128583013	0.51	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	17019	0.17
chr5_147836900_147837051	0.50	CTD-2283N19.1		26605	0.18
chr20_45946936_45948261	0.47	AL031666.2	HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852	352	0.82
chr1_198238845_198238996	0.42	NEK7	NIMA-related kinase 7	48991	0.19
chr3_145879077_145879748	0.41	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	458	0.86
chr2_227516189_227516445	0.40	ENSG00000263363	.	7192	0.31
chr3_195273446_195273682	0.39	AC091633.3		145	0.95
chr2_128492018_128492224	0.39	SFT2D3	SFT2 domain containing 3	33524	0.13
chr2_153267501_153267713	0.39	FMNL2	formin-like 2	75856	0.12
chr1_68697735_68698156	0.36	WLS	wntless Wnt ligand secretion mediator	18	0.98
chr8_57517628_57517779	0.36	RP11-17A4.2		116046	0.06
chr13_32828572_32828723	0.36	FRY	furry homolog (Drosophila)	10158	0.21
chr1_151918063_151918251	0.36	THEM4	thioesterase superfamily member 4	35873	0.1
chr7_151048885_151049126	0.36	NUB1	negative regulator of ubiquitin-like proteins 1	6574	0.16
chr20_14316163_14316462	0.35	FLRT3	fibronectin leucine rich transmembrane protein 3	1942	0.4
chr14_65192350_65192501	0.35	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	1926	0.38
chr10_12746098_12746480	0.35	ENSG00000221331	.	21063	0.25
chr2_63275452_63275960	0.35	AC009501.4		50	0.97
chr9_113800702_113801367	0.35	LPAR1	lysophosphatidic acid receptor 1	53	0.98
chr4_169756047_169756198	0.34	RP11-635L1.3		2034	0.31
chr21_34398214_34398768	0.34	OLIG2	oligodendrocyte lineage transcription factor 2	248	0.93
chr1_84107245_84107582	0.34	ENSG00000223231	.	152147	0.04
chr1_87799796_87800719	0.34	LMO4	LIM domain only 4	2906	0.4
chr7_129933276_129933885	0.33	CPA4	carboxypeptidase A4	461	0.76
chr4_40630076_40630227	0.33	RBM47	RNA binding motif protein 47	1730	0.47
chr1_88180949_88181100	0.33	ENSG00000199318	.	261968	0.02
chr9_18976648_18977105	0.33	FAM154A	family with sequence similarity 154, member A	56310	0.1
chr5_142284312_142284613	0.33	ARHGAP26	Rho GTPase activating protein 26	2425	0.38
chr17_64187141_64188685	0.33	CEP112	centrosomal protein 112kDa	60	0.98
chr4_95367292_95367585	0.32	PDLIM5	PDZ and LIM domain 5	5599	0.33
chr7_105912156_105912307	0.32	NAMPT	nicotinamide phosphoribosyltransferase	13136	0.21
chr4_142380005_142380156	0.32	ENSG00000238695	.	161048	0.04
chr18_33554456_33554607	0.31	C18orf21	chromosome 18 open reading frame 21	1783	0.36
chr6_16737749_16737900	0.31	RP1-151F17.1		23545	0.22
chr7_27153769_27154326	0.31	HOXA-AS2	HOXA cluster antisense RNA 2	492	0.41
chr12_58705170_58705321	0.31	RP11-362K2.2	Protein LOC100506869	232662	0.02
chr8_116675050_116675578	0.31	TRPS1	trichorhinophalangeal syndrome I	1409	0.6
chr5_3597777_3597928	0.31	IRX1	iroquois homeobox 1	1684	0.41
chr10_119303944_119304573	0.30	EMX2OS	EMX2 opposite strand/antisense RNA	321	0.88
chr13_50706829_50707141	0.30	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	50678	0.13
chr14_100573958_100574109	0.30	ENSG00000265154	.	1818	0.23
chr4_139635357_139635508	0.30	ENSG00000238971	.	97488	0.08
chr19_38494188_38494741	0.30	CTC-244M17.1		39971	0.13
chr17_30683527_30683678	0.30	ZNF207	zinc finger protein 207	5675	0.15
chr4_160357796_160357947	0.30	ENSG00000251979	.	70309	0.12
chr20_11887627_11887778	0.30	BTBD3	BTB (POZ) domain containing 3	10863	0.23
chr21_40357766_40357986	0.30	ENSG00000272015	.	91167	0.09
chr12_50748152_50748528	0.30	FAM186A	family with sequence similarity 186, member A	3672	0.22
chr15_96878987_96879612	0.29	ENSG00000222651	.	2809	0.21
chr2_26100038_26101197	0.29	ASXL2	additional sex combs like 2 (Drosophila)	718	0.76
chr2_207998546_207999225	0.29	KLF7	Kruppel-like factor 7 (ubiquitous)	24	0.98
chr6_137544605_137544818	0.29	IFNGR1	interferon gamma receptor 1	4125	0.31
chr18_46620789_46620940	0.29	DYM	dymeclin	2999	0.26
chr18_27841796_27841947	0.29	ENSG00000251702	.	722201	0.0
chr9_17578628_17579355	0.29	SH3GL2	SH3-domain GRB2-like 2	130	0.98
chr11_57530814_57530965	0.29	CTNND1	catenin (cadherin-associated protein), delta 1	436	0.77
chr5_35309735_35309886	0.29	PRLR	prolactin receptor	79016	0.1
chr12_32635785_32635936	0.29	FGD4	FYVE, RhoGEF and PH domain containing 4	3046	0.28
chr5_119820967_119821118	0.29	PRR16	proline rich 16	19716	0.29
chr16_13401641_13401792	0.28	AC003009.1		24724	0.26
chr12_94132438_94132603	0.28	RP11-887P2.5		921	0.64
chr21_36254420_36254945	0.28	RUNX1	runt-related transcription factor 1	4798	0.34
chr22_19073564_19073715	0.28	AC004471.9		35403	0.09
chr16_17931379_17931530	0.28	XYLT1	xylosyltransferase I	366716	0.01
chr3_108988766_108988917	0.28	ENSG00000252889	.	44865	0.15
chr7_37724366_37724517	0.28	GPR141	G protein-coupled receptor 141	966	0.42
chr12_89032903_89033122	0.28	ENSG00000252850	.	57596	0.14
chr7_32102480_32102631	0.28	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	7906	0.33
chr6_50378521_50378672	0.28	TFAP2D	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	302945	0.01
chr3_151560621_151560772	0.27	AADAC	arylacetamide deacetylase	28835	0.17
chr10_81026521_81026806	0.27	ZMIZ1	zinc finger, MIZ-type containing 1	39312	0.18
chr16_86619409_86619937	0.27	FOXL1	forkhead box L1	7558	0.18
chr3_134050593_134051228	0.27	AMOTL2	angiomotin like 2	39844	0.16
chr1_196577911_196578299	0.27	KCNT2	potassium channel, subfamily T, member 2	250	0.94
chr3_33318777_33319866	0.27	FBXL2	F-box and leucine-rich repeat protein 2	353	0.91
chr11_74292413_74292564	0.27	POLD3	polymerase (DNA-directed), delta 3, accessory subunit	11087	0.2
chr3_69434805_69435778	0.27	FRMD4B	FERM domain containing 4B	67	0.99
chr10_4170534_4170685	0.27	KLF6	Kruppel-like factor 6	343136	0.01
chr2_58266503_58266768	0.27	VRK2	vaccinia related kinase 2	7094	0.27
chr1_95330057_95330663	0.27	SLC44A3	solute carrier family 44, member 3	2527	0.28
chr15_43985556_43986365	0.27	CKMT1A	creatine kinase, mitochondrial 1A	109	0.93
chr1_52605764_52605957	0.27	ZFYVE9	zinc finger, FYVE domain containing 9	2186	0.28
chr18_45480065_45480352	0.27	SMAD2	SMAD family member 2	22693	0.23
chr4_89714293_89714444	0.27	FAM13A	family with sequence similarity 13, member A	29984	0.19
chr12_46949518_46949939	0.26	SLC38A2	solute carrier family 38, member 2	183078	0.03
chr1_225842736_225843127	0.26	ENAH	enabled homolog (Drosophila)	2087	0.34
chr2_191624663_191624826	0.26	AC006460.2		51302	0.14
chr19_58488964_58489115	0.26	C19orf18	chromosome 19 open reading frame 18	3137	0.15
chr10_75668708_75669249	0.26	PLAU	plasminogen activator, urokinase	43	0.97
chr13_76026824_76027007	0.26	TBC1D4	TBC1 domain family, member 4	29335	0.19
chr3_168240363_168240514	0.26	ENSG00000207717	.	29204	0.22
chr2_195207760_195207911	0.26	ENSG00000264560	.	215163	0.02
chr2_197103959_197104132	0.26	AC020571.3		20703	0.17
chr5_159524987_159525138	0.26	PWWP2A	PWWP domain containing 2A	21367	0.17
chrX_41379072_41379223	0.26	CASK-AS1	CASK antisense RNA 1	142	0.96
chr9_20490881_20491032	0.26	ENSG00000264941	.	11384	0.23
chr12_46759532_46760006	0.26	SLC38A2	solute carrier family 38, member 2	679	0.75
chr6_58148368_58148782	0.26	ENSG00000212017	.	893645	0.0
chr10_33798417_33798757	0.25	NRP1	neuropilin 1	173397	0.03
chr3_65949778_65949974	0.25	MAGI1-IT1	MAGI1 intronic transcript 1 (non-protein coding)	9643	0.19
chr12_65700600_65700821	0.25	MSRB3	methionine sulfoxide reductase B3	19945	0.21
chr19_30436184_30436558	0.25	URI1	URI1, prefoldin-like chaperone	2946	0.39
chr1_209975427_209975724	0.25	IRF6	interferon regulatory factor 6	64	0.96
chr12_18414636_18414918	0.25	PIK3C2G	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	303	0.95
chr12_115135696_115136278	0.25	TBX3	T-box 3	14018	0.21
chr22_38723559_38723988	0.25	CSNK1E	casein kinase 1, epsilon	9684	0.15
chr20_10502111_10502382	0.25	SLX4IP	SLX4 interacting protein	86295	0.09
chr3_108553094_108553245	0.25	TRAT1	T cell receptor associated transmembrane adaptor 1	11550	0.26
chr12_106699376_106699527	0.25	CKAP4	cytoskeleton-associated protein 4	1394	0.34
chrX_11456470_11456766	0.25	ARHGAP6	Rho GTPase activating protein 6	10725	0.3
chr10_45389082_45389233	0.25	TMEM72	transmembrane protein 72	17491	0.16
chr11_33466056_33466207	0.25	ENSG00000223134	.	90120	0.08
chr3_9006349_9006500	0.25	RAD18	RAD18 homolog (S. cerevisiae)	967	0.6
chr2_103506378_103506656	0.25	TMEM182	transmembrane protein 182	128045	0.06
chr18_77385131_77385282	0.25	CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	54595	0.14
chr16_3911841_3912078	0.25	CREBBP	CREB binding protein	18162	0.21
chr15_79172438_79172758	0.25	MORF4L1	mortality factor 4 like 1	2016	0.31
chr12_51640112_51640647	0.25	DAZAP2	DAZ associated protein 2	7300	0.14
chr4_47544899_47545050	0.25	AC092597.3		17302	0.23
chr1_3736530_3736681	0.25	CEP104	centrosomal protein 104kDa	9265	0.12
chr8_79260999_79261150	0.25	ENSG00000252935	.	49783	0.19
chr7_83932213_83932364	0.25	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	107527	0.08
chr2_176709130_176709424	0.25	AC016751.3		52787	0.15
chr2_158039761_158039912	0.25	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	74274	0.11
chr19_53716573_53716772	0.24	ZNF665	zinc finger protein 665	20045	0.1
chrX_64908310_64908461	0.24	MSN	moesin	20848	0.28
chr6_139292312_139292463	0.24	REPS1	RALBP1 associated Eps domain containing 1	16390	0.23
chr10_114714851_114715858	0.24	RP11-57H14.2		3720	0.26
chr4_177931414_177931624	0.24	ENSG00000222859	.	171077	0.03
chr7_123390243_123390394	0.24	RP11-390E23.6		1196	0.34
chr5_14153831_14154379	0.24	TRIO	trio Rho guanine nucleotide exchange factor	10276	0.32
chr8_41165312_41165463	0.24	SFRP1	secreted frizzled-related protein 1	878	0.57
chr6_133066944_133067095	0.24	RP1-55C23.7		6795	0.13
chr5_77886889_77887187	0.24	LHFPL2	lipoma HMGIC fusion partner-like 2	42064	0.21
chr15_43885730_43886468	0.24	CKMT1B	creatine kinase, mitochondrial 1B	42	0.95
chr2_158113918_158114875	0.24	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	286	0.93
chr10_33422709_33422860	0.24	ENSG00000263576	.	35220	0.17
chr19_39143944_39144135	0.24	ACTN4	actinin, alpha 4	5661	0.13
chr13_40858172_40858323	0.24	ENSG00000207458	.	57283	0.16
chr1_51069078_51069376	0.24	FAF1	Fas (TNFRSF6) associated factor 1	8943	0.23
chr8_49612409_49612560	0.24	EFCAB1	EF-hand calcium binding domain 1	29864	0.25
chr10_31273151_31273302	0.24	ZNF438	zinc finger protein 438	129	0.98
chr6_157381110_157381404	0.24	RP1-137K2.2		59583	0.15
chr2_228735999_228736581	0.23	DAW1	dynein assembly factor with WDR repeat domains 1	33	0.98
chr11_22724799_22724998	0.23	ENSG00000222427	.	15001	0.2
chr20_56749874_56750278	0.23	C20orf85	chromosome 20 open reading frame 85	24116	0.19
chr15_82414957_82415108	0.23	RP11-597K23.2	Uncharacterized protein	34000	0.16
chr13_37397601_37397752	0.23	RFXAP	regulatory factor X-associated protein	4315	0.24
chr20_52370901_52371111	0.23	ENSG00000238468	.	85709	0.09
chr1_202438325_202438476	0.23	PPP1R12B	protein phosphatase 1, regulatory subunit 12B	6529	0.23
chr13_100860702_100860853	0.23	PCCA	propionyl CoA carboxylase, alpha polypeptide	84701	0.1
chr2_188360675_188360826	0.23	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	17618	0.23
chr4_156590981_156591132	0.23	GUCY1A3	guanylate cyclase 1, soluble, alpha 3	2241	0.4
chr4_114705923_114706074	0.23	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	22915	0.27
chr17_33391542_33391948	0.23	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	874	0.45
chr3_162506552_162506703	0.23	ENSG00000238398	.	390136	0.01
chr12_78336292_78336638	0.23	NAV3	neuron navigator 3	23591	0.28
chr20_35924690_35924841	0.23	MANBAL	mannosidase, beta A, lysosomal-like	534	0.79
chr18_55891591_55891981	0.23	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	2983	0.31
chr8_57086542_57086822	0.23	PLAG1	pleiomorphic adenoma gene 1	37156	0.12
chr2_147107195_147107346	0.23	ENSG00000251905	.	204546	0.03
chr9_79483882_79484033	0.23	PRUNE2	prune homolog 2 (Drosophila)	37044	0.21
chr1_200987607_200987758	0.23	KIF21B	kinesin family member 21B	4854	0.21
chr1_181069341_181069492	0.23	IER5	immediate early response 5	11778	0.23
chr5_123252700_123253101	0.23	CSNK1G3	casein kinase 1, gamma 3	328781	0.01
chr6_83094369_83094520	0.22	TPBG	trophoblast glycoprotein	20483	0.28
chr6_1614659_1614953	0.22	FOXC1	forkhead box C1	4125	0.35
chr2_195590152_195590303	0.22	ENSG00000252517	.	61329	0.16
chr7_92254665_92254816	0.22	FAM133B	family with sequence similarity 133, member B	35032	0.17
chr21_19152947_19153098	0.22	AL109761.5		12783	0.23
chr4_15963408_15963559	0.22	FGFBP2	fibroblast growth factor binding protein 2	1376	0.42
chr12_96094020_96094171	0.22	ENSG00000212448	.	82630	0.07
chr12_27901688_27901839	0.22	ENSG00000252585	.	4044	0.14
chr5_73839186_73839374	0.22	HEXB	hexosaminidase B (beta polypeptide)	96568	0.07
chr15_30112674_30113382	0.22	TJP1	tight junction protein 1	723	0.64
chr4_48240161_48240435	0.22	TEC	tec protein tyrosine kinase	31583	0.18
chr7_93003610_93003782	0.22	CCDC132	coiled-coil domain containing 132	24486	0.23
chr7_115670709_115671033	0.22	TFEC	transcription factor EC	4	0.99
chr4_459906_460057	0.22	ENSG00000252150	.	1444	0.36
chr5_17223836_17223987	0.22	BASP1	brain abundant, membrane attached signal protein 1	6242	0.19
chr4_141984739_141984890	0.22	RNF150	ring finger protein 150	9934	0.3
chr2_43822335_43823890	0.22	THADA	thyroid adenoma associated	1	0.98
chr1_189407105_189407256	0.22	ENSG00000252553	.	228206	0.02
chr17_39742070_39742221	0.22	KRT14	keratin 14	1028	0.36
chr5_73536836_73537130	0.22	ENSG00000222551	.	30607	0.23
chrX_39548256_39548819	0.22	ENSG00000263730	.	28067	0.24
chr9_96819103_96819334	0.22	PTPDC1	protein tyrosine phosphatase domain containing 1	26142	0.21
chr15_71606160_71606311	0.22	RP11-592N21.2		28428	0.23
chr7_38546645_38546796	0.22	ENSG00000241756	.	24219	0.23
chr11_128453017_128453335	0.22	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	4277	0.28
chr15_34875013_34876331	0.22	GOLGA8B	golgin A8 family, member B	99	0.96
chr6_7727536_7728016	0.22	BMP6	bone morphogenetic protein 6	746	0.78
chr13_52108240_52108391	0.22	INTS6-AS1	INTS6 antisense RNA 1	7379	0.15
chr10_79470838_79471281	0.22	ENSG00000199664	.	65754	0.1
chr22_46436012_46436163	0.22	RP6-109B7.5		12886	0.1
chrX_95690881_95691032	0.22	ENSG00000223260	.	25175	0.28
chr4_88817282_88817552	0.22	MEPE	matrix extracellular phosphoglycoprotein	63278	0.1
chr3_71591333_71591803	0.21	ENSG00000221264	.	328	0.83
chr9_89952337_89952906	0.21	ENSG00000212421	.	77256	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.1	0.4	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.3	GO:0060013	righting reflex(GO:0060013)
0.1	0.1	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.1	0.2	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.2	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.1	0.2	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0032808	lacrimal gland development(GO:0032808)
0.1	0.3	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.1	0.2	GO:0061430	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.3	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.1	0.2	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.2	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.2	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0052169	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.2	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.2	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.3	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.2	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.4	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.4	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.1	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.2	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.0	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0010665	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0003160	endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0	0.3	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0002604	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0001946	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.0	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.1	GO:0032332	positive regulation of chondrocyte differentiation(GO:0032332)
0.0	0.0	GO:0061101	neuroendocrine cell differentiation(GO:0061101)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.0	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0032801	receptor catabolic process(GO:0032801)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0032415	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.0	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0010919	regulation of inositol phosphate biosynthetic process(GO:0010919)
0.0	0.1	GO:0072666	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:0045425	interleukin-3 production(GO:0032632) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.0	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.0	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.0	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.2	GO:0001738	morphogenesis of a polarized epithelium(GO:0001738)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0034505	tooth mineralization(GO:0034505)
0.0	0.0	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.4	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.0	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.0	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.1	GO:0051026	chiasma assembly(GO:0051026)
0.0	0.0	GO:1902745	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.2	GO:0001755	neural crest cell migration(GO:0001755)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.0	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.0	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0019359	nicotinamide nucleotide biosynthetic process(GO:0019359)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0031268	pseudopodium organization(GO:0031268)
0.0	0.0	GO:0048505	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.2	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	0.0	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	GO:0030904	retromer complex(GO:0030904)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0071437	invadopodium(GO:0071437)
0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.2	GO:0043256	laminin complex(GO:0043256)
0.2	GO:0099738	cell cortex region(GO:0099738)
0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	GO:0000800	lateral element(GO:0000800)
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	GO:0001527	microfibril(GO:0001527)
0.1	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.2	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.2	GO:0009925	basal plasma membrane(GO:0009925)
0.2	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.1	GO:0010369	chromocenter(GO:0010369)
0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.2	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1	GO:0031143	pseudopodium(GO:0031143)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.3	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.3	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.1	0.3	GO:0004904	interferon receptor activity(GO:0004904)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.2	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.4	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0042805	actinin binding(GO:0042805)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.2	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.2	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.3	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.3	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0050543	icosatetraenoic acid binding(GO:0050543) arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.4	GO:0045296	cadherin binding(GO:0045296)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.3	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.0	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0005109	frizzled binding(GO:0005109)
0.0	0.2	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.1	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0051637	obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.0	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	PID NECTIN PATHWAY	Nectin adhesion pathway
0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	PID FGF PATHWAY	FGF signaling pathway
0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.3	PID IL1 PATHWAY	IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.0	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.6	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.3	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.2	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis