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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for HOXB8

Z-value: 1.60

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Transcription factors associated with HOXB8

Gene Symbol	Gene ID	Gene Info
HOXB8 Ensembl NCBI GeneCards UniProt	ENSG00000120068.5	homeobox B8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_46690518_46690840	HOXB8	162	0.861182	0.52	1.5e-01	Click!
chr17_46694958_46695109	HOXB8	2555	0.107403	0.51	1.6e-01	Click!
chr17_46689926_46690387	HOXB8	685	0.393577	0.51	1.6e-01	Click!
chr17_46692331_46692482	HOXB8	72	0.919280	0.38	3.1e-01	Click!
chr17_46691299_46691963	HOXB8	435	0.604595	0.25	5.1e-01	Click!

Activity of the HOXB8 motif across conditions

Conditions sorted by the z-value of the HOXB8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_41126076_41126227	0.72	CNTN1	contactin 1	10002	0.31
chr15_49717786_49717937	0.70	FGF7	fibroblast growth factor 7	2404	0.35
chr10_15546091_15546242	0.69	FAM171A1	family with sequence similarity 171, member A1	133105	0.05
chr5_17021245_17021396	0.68	BASP1	brain abundant, membrane attached signal protein 1	44387	0.15
chr14_88921501_88921652	0.65	PTPN21	protein tyrosine phosphatase, non-receptor type 21	14384	0.17
chr12_121890067_121890659	0.60	RNF34	ring finger protein 34, E3 ubiquitin protein ligase	43085	0.14
chr2_36581700_36582677	0.59	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	881	0.74
chr11_88250593_88250868	0.59	GRM5-AS1	GRM5 antisense RNA 1	5814	0.32
chr17_67056652_67056803	0.58	ABCA9	ATP-binding cassette, sub-family A (ABC1), member 9	320	0.9
chr13_51804353_51804504	0.58	FAM124A	family with sequence similarity 124A	7921	0.25
chr3_157047289_157047440	0.57	ENSG00000243176	.	43415	0.17
chr7_80546807_80546971	0.57	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	1610	0.56
chr18_6730820_6730971	0.57	ARHGAP28	Rho GTPase activating protein 28	853	0.47
chr8_89311514_89311910	0.57	RP11-586K2.1		27353	0.2
chr4_114680711_114680982	0.56	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	1378	0.6
chr5_102203662_102203813	0.55	PAM	peptidylglycine alpha-amidating monooxygenase	1917	0.5
chr4_182877915_182878066	0.54	ENSG00000251742	.	121729	0.06
chr18_57362819_57362970	0.54	RP11-2N1.2		797	0.55
chr18_32075255_32075406	0.53	DTNA	dystrobrevin, alpha	1463	0.59
chr15_82185548_82185774	0.52	ENSG00000222521	.	150974	0.04
chr9_90344351_90344502	0.52	CTSL	cathepsin L	3371	0.24
chr14_52821573_52821780	0.52	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	40563	0.18
chr2_164588659_164588810	0.51	FIGN	fidgetin	3783	0.39
chr4_148947037_148947237	0.51	RP11-76G10.1		120485	0.06
chr20_4928306_4928457	0.51	SLC23A2	solute carrier family 23 (ascorbic acid transporter), member 2	48088	0.12
chr10_32110756_32110907	0.51	ARHGAP12	Rho GTPase activating protein 12	32277	0.21
chr15_86737409_86737560	0.51	ENSG00000200206	.	20983	0.21
chr1_224075422_224075812	0.50	TP53BP2	tumor protein p53 binding protein, 2	41943	0.17
chr6_149033535_149033686	0.50	UST	uronyl-2-sulfotransferase	34854	0.23
chr3_98666159_98666310	0.50	ENSG00000207331	.	38931	0.15
chr5_19885020_19885171	0.50	CDH18	cadherin 18, type 2	1286	0.64
chr12_50665639_50665877	0.50	LIMA1	LIM domain and actin binding 1	11509	0.13
chr18_74798828_74799607	0.50	MBP	myelin basic protein	18000	0.27
chr18_37278755_37278906	0.50	ENSG00000212354	.	20244	0.23
chr5_55366515_55366666	0.49	ANKRD55	ankyrin repeat domain 55	46188	0.11
chr13_75466427_75466770	0.49	ENSG00000206812	.	217126	0.02
chr6_130687578_130688581	0.49	TMEM200A	transmembrane protein 200A	1200	0.43
chr5_106729540_106729691	0.49	EFNA5	ephrin-A5	276713	0.02
chr15_96878987_96879612	0.49	ENSG00000222651	.	2809	0.21
chr5_54277483_54277634	0.48	ESM1	endothelial cell-specific molecule 1	3863	0.2
chr13_79182716_79183828	0.48	POU4F1	POU class 4 homeobox 1	5599	0.19
chr12_12658847_12659363	0.48	DUSP16	dual specificity phosphatase 16	14954	0.24
chr2_46933523_46933944	0.47	SOCS5	suppressor of cytokine signaling 5	7407	0.22
chr9_110410682_110410833	0.47	ENSG00000202308	.	14770	0.26
chr17_46670468_46671125	0.47	HOXB5	homeobox B5	527	0.46
chr5_122493680_122494140	0.46	AC106786.1		67916	0.1
chr13_63983070_63983221	0.46	LINC00395	long intergenic non-protein coding RNA 395	308006	0.01
chr13_33856770_33856921	0.46	STARD13	StAR-related lipid transfer (START) domain containing 13	3047	0.27
chr15_49716260_49716444	0.46	FGF7	fibroblast growth factor 7	895	0.66
chr6_134212280_134212761	0.45	RP3-323P13.2		554	0.76
chrX_130036036_130037401	0.45	ENOX2	ecto-NOX disulfide-thiol exchanger 2	460	0.9
chr8_116675050_116675578	0.45	TRPS1	trichorhinophalangeal syndrome I	1409	0.6
chr15_38558340_38558572	0.45	SPRED1	sprouty-related, EVH1 domain containing 1	13074	0.3
chr3_170442838_170442989	0.45	RP11-373E16.3		68562	0.11
chr21_28849596_28849747	0.45	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	510839	0.0
chr2_183289734_183289997	0.45	PDE1A	phosphodiesterase 1A, calmodulin-dependent	1884	0.49
chr4_112477852_112478003	0.44	ENSG00000200963	.	225359	0.02
chr12_91721216_91721367	0.44	DCN	decorin	144391	0.05
chr12_115135696_115136278	0.44	TBX3	T-box 3	14018	0.21
chr3_70854632_70854783	0.44	ENSG00000206939	.	2794	0.39
chr10_131770273_131770744	0.44	EBF3	early B-cell factor 3	8403	0.31
chr3_46607065_46607798	0.44	LRRC2	leucine rich repeat containing 2	609	0.64
chr22_46462327_46462478	0.43	RP6-109B7.4		3369	0.13
chr12_88972313_88972545	0.43	KITLG	KIT ligand	1809	0.39
chr12_91571050_91571576	0.42	DCN	decorin	1016	0.66
chr12_91572648_91572799	0.42	DCN	decorin	394	0.91
chr7_83944593_83944744	0.42	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	119907	0.07
chr5_66771392_66771543	0.42	ENSG00000222939	.	11031	0.32
chr7_27386304_27386479	0.41	EVX1-AS	EVX1 antisense RNA	99543	0.05
chr4_19653015_19653166	0.41	ENSG00000251816	.	469611	0.01
chr5_95070519_95070670	0.41	CTD-2154I11.2		2595	0.24
chr21_17910454_17910605	0.41	ENSG00000207638	.	880	0.55
chr3_24650735_24650886	0.41	ENSG00000265028	.	87884	0.09
chr2_3465758_3466116	0.41	TRAPPC12	trafficking protein particle complex 12	3507	0.21
chr18_53089837_53090372	0.41	TCF4	transcription factor 4	361	0.89
chr2_55810508_55810659	0.41	ENSG00000212175	.	17744	0.15
chr6_33589286_33590289	0.41	ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	626	0.65
chr10_15126072_15126273	0.40	ACBD7	acyl-CoA binding domain containing 7	4603	0.18
chr2_236403954_236404487	0.40	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	1469	0.47
chr4_42361739_42361897	0.40	RP11-63A11.1		31432	0.19
chr10_34630198_34630349	0.40	PARD3	par-3 family cell polarity regulator	31188	0.25
chr9_6218213_6218406	0.40	IL33	interleukin 33	2500	0.39
chr13_99148949_99149100	0.40	STK24	serine/threonine kinase 24	22497	0.2
chr3_197036138_197036422	0.40	DLG1	discs, large homolog 1 (Drosophila)	10109	0.16
chr15_61326296_61326540	0.40	RP11-39M21.1		147030	0.04
chr2_43859187_43859338	0.40	PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	5150	0.22
chr13_80658291_80658484	0.40	SPRY2	sprouty homolog 2 (Drosophila)	255407	0.02
chr12_91573704_91574005	0.40	DCN	decorin	288	0.94
chr15_38853288_38853439	0.40	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	883	0.6
chr2_144339822_144340188	0.39	RP11-570L15.2		10331	0.21
chr11_121967218_121967559	0.39	ENSG00000207971	.	3164	0.21
chr3_85530673_85530848	0.39	ENSG00000264084	.	95900	0.09
chrX_33227444_33227711	0.39	DMD	dystrophin	1852	0.53
chr1_178698179_178698330	0.39	RP11-428K3.1		2834	0.23
chr13_74636535_74636686	0.39	KLF12	Kruppel-like factor 12	67424	0.15
chr1_82300138_82300289	0.38	LPHN2	latrophilin 2	34131	0.24
chr2_30834902_30835053	0.38	LCLAT1	lysocardiolipin acyltransferase 1	164708	0.04
chr20_50178684_50179923	0.38	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	67	0.99
chr4_152147913_152148065	0.38	SH3D19	SH3 domain containing 19	239	0.94
chr16_87414863_87415370	0.38	FBXO31	F-box protein 31	2247	0.19
chr1_56547076_56547335	0.38	PIGQP1	phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1	142252	0.05
chr2_216325673_216325824	0.38	AC012462.1		24772	0.2
chr6_121756849_121757212	0.38	GJA1	gap junction protein, alpha 1, 43kDa	192	0.94
chr18_55993007_55993158	0.38	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	2530	0.32
chr5_98107570_98107721	0.38	RGMB-AS1	RGMB antisense RNA 1	837	0.59
chr3_76360329_76360480	0.38	ENSG00000212104	.	106727	0.08
chr7_19136246_19136397	0.38	AC003986.6		15776	0.16
chr12_19375312_19375463	0.38	PLEKHA5	pleckstrin homology domain containing, family A member 5	14471	0.22
chr4_188524057_188524208	0.38	ZFP42	ZFP42 zinc finger protein	392793	0.01
chr7_84267660_84267811	0.38	ENSG00000265050	.	27589	0.27
chr10_24738869_24739102	0.38	KIAA1217	KIAA1217	623	0.8
chr6_88875424_88876640	0.38	CNR1	cannabinoid receptor 1 (brain)	46	0.99
chr5_102202832_102203172	0.37	PAM	peptidylglycine alpha-amidating monooxygenase	1182	0.66
chr11_85427844_85428144	0.37	SYTL2	synaptotagmin-like 2	290	0.9
chr3_88191159_88191414	0.37	ZNF654	zinc finger protein 654	3032	0.24
chr8_116672724_116672875	0.37	TRPS1	trichorhinophalangeal syndrome I	1106	0.68
chr13_76300256_76300407	0.37	LMO7	LIM domain 7	34172	0.19
chr7_1329739_1330674	0.37	UNCX	UNC homeobox	57663	0.12
chr4_102182969_102183120	0.37	ENSG00000221265	.	68527	0.12
chr21_17444306_17444457	0.37	ENSG00000252273	.	36552	0.23
chr18_32287572_32287755	0.37	DTNA	dystrobrevin, alpha	2585	0.38
chr2_48375649_48375800	0.37	ENSG00000201010	.	68990	0.12
chr11_35642709_35642958	0.37	FJX1	four jointed box 1 (Drosophila)	3098	0.31
chr1_72809770_72809921	0.37	NEGR1	neuronal growth regulator 1	61428	0.16
chr7_35936307_35936458	0.37	SEPT7	septin 7	16856	0.2
chr4_162369489_162369640	0.37	RP11-234O6.2		69459	0.14
chr16_62023154_62023305	0.36	CDH8	cadherin 8, type 2	32277	0.22
chr15_86292668_86292859	0.36	RP11-158M2.3		749	0.49
chr5_31806865_31807016	0.36	PDZD2	PDZ domain containing 2	7909	0.14
chr11_32078314_32078465	0.36	RP1-17K7.3		3583	0.18
chr2_239766868_239767019	0.36	TWIST2	twist family bHLH transcription factor 2	10270	0.26
chr10_104805332_104805483	0.36	NT5C2	5'-nucleotidase, cytosolic II	48718	0.14
chr12_78128206_78128357	0.36	NAV3	neuron navigator 3	96404	0.09
chrX_49487429_49487580	0.36	PAGE1	P antigen family, member 1 (prostate associated)	26908	0.16
chr17_78448561_78449185	0.36	NPTX1	neuronal pentraxin I	1531	0.39
chr12_77584113_77584264	0.36	ENSG00000238769	.	27383	0.26
chr4_158936309_158936460	0.36	FAM198B	family with sequence similarity 198, member B	144449	0.04
chr16_88228072_88228223	0.36	BANP	BTG3 associated nuclear protein	224523	0.02
chr5_171189403_171189554	0.36	ENSG00000264303	.	8056	0.2
chr3_188840890_188841041	0.36	TPRG1	tumor protein p63 regulated 1	23055	0.27
chr1_61559773_61559924	0.36	NFIA	nuclear factor I/A	5764	0.22
chr12_1427708_1428104	0.35	RP5-951N9.2		67093	0.11
chr3_114804047_114804198	0.35	ZBTB20	zinc finger and BTB domain containing 20	13900	0.32
chr7_121078096_121078495	0.35	FAM3C	family with sequence similarity 3, member C	41877	0.19
chr5_151907050_151907201	0.35	NMUR2	neuromedin U receptor 2	122285	0.07
chr7_116169835_116170224	0.35	CAV1	caveolin 1, caveolae protein, 22kDa	3682	0.19
chr18_6730462_6730679	0.35	ARHGAP28	Rho GTPase activating protein 28	528	0.57
chr9_99318614_99318765	0.35	CDC14B	cell division cycle 14B	10423	0.26
chr10_32230075_32230289	0.35	ARHGAP12	Rho GTPase activating protein 12	12440	0.24
chr8_16612533_16612758	0.35	ENSG00000264092	.	108360	0.07
chrX_11456470_11456766	0.35	ARHGAP6	Rho GTPase activating protein 6	10725	0.3
chr12_124145064_124145215	0.35	TCTN2	tectonic family member 2	10521	0.13
chr15_73194841_73195065	0.35	ADPGK	ADP-dependent glucokinase	116766	0.05
chr10_4805097_4805248	0.35	AKR1E2	aldo-keto reductase family 1, member E2	23649	0.25
chr11_26211497_26211648	0.34	ANO3	anoctamin 3	743	0.81
chr13_31783925_31784161	0.34	B3GALTL	beta 1,3-galactosyltransferase-like	9970	0.27
chr16_55401886_55402037	0.34	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	21651	0.18
chr18_10458716_10458867	0.34	APCDD1	adenomatosis polyposis coli down-regulated 1	3812	0.31
chr3_69231445_69231789	0.34	FRMD4B	FERM domain containing 4B	16804	0.21
chr3_104078695_104079148	0.34	ENSG00000265076	.	305281	0.01
chr11_69048256_69048407	0.34	MYEOV	myeloma overexpressed	13274	0.27
chr4_112858463_112858614	0.34	C4orf32	chromosome 4 open reading frame 32	208015	0.02
chr14_99731258_99732023	0.34	AL109767.1		2355	0.32
chr2_239752907_239753200	0.34	TWIST2	twist family bHLH transcription factor 2	3620	0.32
chr2_31639599_31639781	0.34	XDH	xanthine dehydrogenase	2109	0.44
chr8_118893253_118893404	0.34	EXT1	exostosin glycosyltransferase 1	229325	0.02
chr7_116141197_116141631	0.34	CAV2	caveolin 2	1580	0.29
chr9_36029255_36029406	0.34	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	7100	0.21
chr2_148890253_148890404	0.34	ORC4	origin recognition complex, subunit 4	111181	0.06
chr6_23003728_23003960	0.34	ENSG00000207394	.	121471	0.07
chr2_156551944_156552095	0.34	ENSG00000206718	.	365086	0.01
chr12_63439569_63439720	0.34	AVPR1A	arginine vasopressin receptor 1A	104315	0.07
chr3_27809970_27810181	0.34	EOMES	eomesodermin	45869	0.2
chr9_73178482_73178798	0.34	ENSG00000272232	.	15737	0.27
chr4_27007063_27007214	0.34	STIM2	stromal interaction molecule 2	2516	0.43
chr3_141106502_141106653	0.34	ZBTB38	zinc finger and BTB domain containing 38	77	0.98
chr6_37410160_37410312	0.33	CMTR1	cap methyltransferase 1	9240	0.22
chr3_28328405_28328556	0.33	CMC1	C-x(9)-C motif containing 1	33261	0.19
chr2_175194144_175194295	0.33	SP9	Sp9 transcription factor	5455	0.18
chr8_98000597_98000748	0.33	CPQ	carboxypeptidase Q	41025	0.21
chr12_91569475_91569626	0.33	DCN	decorin	2779	0.37
chr13_48093959_48094110	0.33	ENSG00000244521	.	60665	0.16
chr15_35950174_35950564	0.33	DPH6	diphthamine biosynthesis 6	111976	0.07
chr7_87941720_87941871	0.33	STEAP4	STEAP family member 4	5589	0.25
chr9_3824695_3824846	0.33	RP11-252M18.3		50814	0.17
chr10_22908844_22909013	0.33	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	28286	0.24
chr2_216299376_216299642	0.33	FN1	fibronectin 1	1281	0.4
chr4_113739356_113739869	0.33	ANK2	ankyrin 2, neuronal	347	0.9
chr15_66134037_66134191	0.33	ENSG00000252715	.	1708	0.36
chr3_93834419_93834570	0.33	ENSG00000253062	.	17084	0.2
chr6_161450018_161450251	0.33	MAP3K4	mitogen-activated protein kinase kinase kinase 4	6908	0.26
chr11_125931766_125932579	0.33	CDON	cell adhesion associated, oncogene regulated	534	0.8
chr11_131926444_131926595	0.33	RP11-697E14.2		71964	0.12
chr9_118131927_118132078	0.33	DEC1	deleted in esophageal cancer 1	227905	0.02
chr2_238320061_238320294	0.33	COL6A3	collagen, type VI, alpha 3	2614	0.29
chr12_124084080_124084231	0.33	DDX55	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	2491	0.19
chr12_911577_911728	0.32	ENSG00000221439	.	21353	0.2
chr7_125568032_125568183	0.32	ENSG00000221418	.	112176	0.08
chr7_84119974_84120125	0.32	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	1816	0.53
chr17_59093767_59093918	0.32	RP11-264B14.1		53641	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4	1.6	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.3	1.2	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3	0.5	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.3	0.3	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.2	1.0	GO:0043589	skin morphogenesis(GO:0043589)
0.2	0.6	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.2	0.7	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.2	0.5	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.2	0.5	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2	1.0	GO:0016264	gap junction assembly(GO:0016264)
0.2	0.8	GO:0014850	response to muscle activity(GO:0014850)
0.1	0.3	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.1	0.4	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.6	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.4	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.4	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.4	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.5	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.2	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.3	GO:0045759	negative regulation of action potential(GO:0045759)
0.1	0.3	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.3	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.2	GO:0060677	ureteric bud elongation(GO:0060677)
0.1	0.3	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.1	0.4	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1	0.3	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.2	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.4	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.2	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.1	0.3	GO:0060596	mammary placode formation(GO:0060596)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	1.4	GO:0042474	middle ear morphogenesis(GO:0042474)
0.1	0.3	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.1	0.3	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.4	GO:0070141	response to UV-A(GO:0070141)
0.1	0.4	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.3	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.1	0.3	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.4	GO:0001757	somite specification(GO:0001757)
0.1	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.1	0.3	GO:0060044	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.1	0.1	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.1	1.9	GO:0030199	collagen fibril organization(GO:0030199)
0.1	0.2	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.7	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.1	0.5	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.1	1.3	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.1	0.2	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1	0.3	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1	0.4	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.1	0.3	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.1	0.2	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.2	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1	0.2	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.1	0.2	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	0.1	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.1	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.1	GO:0060535	trachea cartilage development(GO:0060534) trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.1	0.1	GO:0060437	lung growth(GO:0060437)
0.1	0.3	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.1	0.6	GO:0030238	male sex determination(GO:0030238)
0.1	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.3	GO:0033327	Leydig cell differentiation(GO:0033327)
0.1	0.2	GO:0010659	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1	0.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.5	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.1	0.4	GO:0043113	receptor clustering(GO:0043113)
0.1	0.2	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.1	0.2	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.1	0.2	GO:0008354	germ cell migration(GO:0008354)
0.1	0.2	GO:0042268	regulation of cytolysis(GO:0042268)
0.1	0.2	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1	0.5	GO:0031000	response to caffeine(GO:0031000)
0.1	0.9	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.1	0.1	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.5	GO:0060996	dendritic spine development(GO:0060996)
0.1	0.1	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.1	0.3	GO:0051044	regulation of membrane protein ectodomain proteolysis(GO:0051043) positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1	0.2	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1	0.2	GO:0008218	bioluminescence(GO:0008218)
0.1	0.2	GO:0060753	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1	0.4	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.1	0.7	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.1	0.4	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.1	0.2	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.2	GO:0060013	righting reflex(GO:0060013)
0.1	0.1	GO:0060435	bronchiole development(GO:0060435)
0.1	0.2	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.2	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.1	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0	0.2	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	1.3	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.2	GO:1903427	negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of reactive oxygen species biosynthetic process(GO:1903427) negative regulation of nitric oxide metabolic process(GO:1904406)
0.0	0.2	GO:0002860	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.0	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.0	0.2	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0048840	otolith development(GO:0048840)
0.0	0.2	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0098900	regulation of action potential(GO:0098900)
0.0	0.7	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.1	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0090197	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.4	GO:0007520	syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0	0.2	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.2	GO:0008228	opsonization(GO:0008228)
0.0	0.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.0	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) regulation of sprouting angiogenesis(GO:1903670) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.4	GO:0071456	cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.0	0.2	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.6	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.1	GO:0051148	negative regulation of muscle cell differentiation(GO:0051148)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.3	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.1	GO:0014044	Schwann cell development(GO:0014044) myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0043438	acetoacetic acid metabolic process(GO:0043438)
0.0	0.0	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.2	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.2	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.1	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0051154	negative regulation of striated muscle cell differentiation(GO:0051154)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.6	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.2	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.2	GO:0045822	negative regulation of heart contraction(GO:0045822)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:2000649	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.0	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.2	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.1	GO:1904019	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.2	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:1903170	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.2	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.3	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.1	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.0	GO:0009125	nucleoside monophosphate catabolic process(GO:0009125)
0.0	0.1	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.0	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.2	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	2.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.1	GO:0050746	regulation of lipoprotein metabolic process(GO:0050746)
0.0	0.0	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.0	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0035268	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.0	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.1	GO:0045064	T-helper 2 cell differentiation(GO:0045064) regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.1	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0061054	dermatome development(GO:0061054)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0071384	cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.2	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.0	GO:0007442	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.4	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0021895	cerebral cortex neuron differentiation(GO:0021895)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0015695	organic cation transport(GO:0015695)
0.0	0.0	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0008595	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.1	GO:0045446	endothelial cell differentiation(GO:0045446)
0.0	0.2	GO:1902749	regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0	0.0	GO:0051580	regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940) positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.2	GO:0008211	glucocorticoid metabolic process(GO:0008211)
0.0	0.1	GO:0090025	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.1	GO:0031076	embryonic camera-type eye development(GO:0031076)
0.0	0.1	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.2	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.0	GO:0061047	positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0	0.2	GO:0008589	regulation of smoothened signaling pathway(GO:0008589)
0.0	0.1	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0071470	cellular response to osmotic stress(GO:0071470)
0.0	0.1	GO:0001885	endothelial cell development(GO:0001885)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.0	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.2	GO:0007566	embryo implantation(GO:0007566)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0032099	negative regulation of appetite(GO:0032099)
0.0	0.7	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.2	GO:0043278	response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789) eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0044068	modulation by virus of host process(GO:0019054) modulation by symbiont of host cellular process(GO:0044068)
0.0	0.0	GO:0090505	wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0010523	negative regulation of calcium ion transport into cytosol(GO:0010523)
0.0	0.0	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.0	GO:0090281	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0001710	mesodermal cell fate commitment(GO:0001710)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.3	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.0	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	0.5	GO:0001764	neuron migration(GO:0001764)
0.0	0.1	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.0	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.0	GO:0021924	cell proliferation in hindbrain(GO:0021534) cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.0	0.0	GO:0032096	negative regulation of response to food(GO:0032096)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.4	GO:0042633	molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.0	GO:0003097	renal water transport(GO:0003097) renal water absorption(GO:0070295)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.0	0.0	GO:0003321	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0015865	purine nucleotide transport(GO:0015865) adenine nucleotide transport(GO:0051503)
0.0	0.1	GO:0030299	intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.1	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.0	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0060438	trachea development(GO:0060438)
0.0	0.1	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.0	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0061037	negative regulation of cartilage development(GO:0061037)
0.0	0.0	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.1	GO:0015697	quaternary ammonium group transport(GO:0015697)
0.0	0.0	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.0	0.0	GO:0032222	regulation of synaptic transmission, cholinergic(GO:0032222)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.0	0.0	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.0	GO:0003207	cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	2.4	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	0.8	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.2	0.5	GO:0005588	collagen type V trimer(GO:0005588)
0.2	1.4	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.6	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.7	GO:0002102	podosome(GO:0002102)
0.1	0.3	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	0.5	GO:0005606	laminin-1 complex(GO:0005606)
0.1	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	0.6	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.2	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.3	GO:0005915	zonula adherens(GO:0005915)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.4	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	0.7	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.4	GO:0098644	complex of collagen trimers(GO:0098644)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.3	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.8	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.3	GO:0030673	axolemma(GO:0030673)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.4	GO:0005581	collagen trimer(GO:0005581)
0.0	0.8	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	1.6	GO:0005604	basement membrane(GO:0005604)
0.0	0.7	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.9	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.3	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0045178	basal part of cell(GO:0045178)
0.0	1.3	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.8	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	4.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.2	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.7	GO:0016459	myosin complex(GO:0016459)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	1.5	GO:0030016	myofibril(GO:0030016)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.9	GO:0030426	growth cone(GO:0030426)
0.0	0.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.0	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.0	GO:0033646	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.3	GO:0044309	neuron spine(GO:0044309)
0.0	0.3	GO:0031526	brush border membrane(GO:0031526)
0.0	1.4	GO:0005911	cell-cell junction(GO:0005911)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.3	1.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.2	0.7	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.2	0.9	GO:0045499	chemorepellent activity(GO:0045499)
0.2	0.7	GO:0016842	amidine-lyase activity(GO:0016842)
0.2	1.0	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2	0.6	GO:0030215	semaphorin receptor binding(GO:0030215)
0.2	0.5	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.7	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.4	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	1.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.4	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	0.4	GO:0042805	actinin binding(GO:0042805)
0.1	0.8	GO:0043274	phospholipase binding(GO:0043274)
0.1	0.3	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	2.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	0.3	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.3	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.8	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.1	0.6	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.8	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1	0.8	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.1	0.4	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.1	0.5	GO:0019966	interleukin-1 binding(GO:0019966)
0.1	0.3	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.1	GO:0043559	insulin binding(GO:0043559)
0.1	0.4	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.1	0.8	GO:0045295	gamma-catenin binding(GO:0045295)
0.1	0.2	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.1	0.3	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.4	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	0.3	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.1	0.2	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.4	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	0.3	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.1	GO:0098531	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1	0.6	GO:0050780	dopamine receptor binding(GO:0050780)
0.1	0.3	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.1	0.3	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.2	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.1	0.2	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.1	0.2	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.1	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.1	0.4	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	0.2	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	0.7	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.1	0.2	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1	0.3	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.1	1.6	GO:0005518	collagen binding(GO:0005518)
0.0	0.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.2	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.3	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.4	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.5	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.6	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.8	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.3	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.3	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.0	0.4	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.0	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	2.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.3	GO:0005123	death receptor binding(GO:0005123)
0.0	0.2	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.3	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.2	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.5	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.2	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.1	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.8	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	0.3	GO:0030553	cGMP binding(GO:0030553)
0.0	0.5	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.6	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.1	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0004936	alpha-adrenergic receptor activity(GO:0004936)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0042923	neuropeptide binding(GO:0042923)
0.0	0.4	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.0	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.2	GO:0005372	water transmembrane transporter activity(GO:0005372)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	1.1	GO:0008201	heparin binding(GO:0008201)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.0	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0031782	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.0	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.3	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	3.4	GO:0030528	obsolete transcription regulator activity(GO:0030528)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.0	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.0	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.0	GO:0005035	death receptor activity(GO:0005035)
0.0	0.1	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.8	GO:0005179	hormone activity(GO:0005179)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.2	GO:0070330	aromatase activity(GO:0070330)
0.0	0.0	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	0.9	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	0.2	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	4.0	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.7	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.2	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.7	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	1.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.8	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.3	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.2	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.5	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	3.7	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0	0.6	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.3	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.6	PID FGF PATHWAY	FGF signaling pathway
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.4	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.2	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.1	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	1.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	1.5	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.1	0.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	0.2	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.1	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.1	0.7	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	0.6	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.1	0.6	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	0.7	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	0.9	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	0.6	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1	0.7	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	0.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	1.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	1.0	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	0.8	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.9	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	1.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.0	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	1.1	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.4	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	2.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.0	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.3	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.2	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.3	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.7	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.4	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.4	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.4	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	1.2	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.2	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.3	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.4	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.3	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.2	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.0	REACTOME AQUAPORIN MEDIATED TRANSPORT	Genes involved in Aquaporin-mediated transport
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.0	REACTOME SIGNALING BY NOTCH3	Genes involved in Signaling by NOTCH3
0.0	0.0	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.1	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane

Results for HOXB8

Z-value: 1.60

Motif logo

Transcription factors associated with HOXB8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the HOXB8 motif across conditions

Conditions sorted by the z-value of the HOXB8 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: