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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXC12_HOXD12

Z-value: 1.42

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Transcription factors associated with HOXC12_HOXD12

Gene Symbol	Gene ID	Gene Info
HOXC12 Ensembl NCBI GeneCards UniProt	ENSG00000123407.3	HOXC12
HOXD12 Ensembl NCBI GeneCards UniProt	ENSG00000170178.5	HOXD12

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXC12	chr12_54344046_54344197	4497	0.084649	-0.48	1.9e-01	Click!
HOXC12	chr12_54348806_54348957	263	0.784258	-0.48	1.9e-01	Click!
HOXC12	chr12_54349321_54349472	778	0.371124	-0.43	2.5e-01	Click!
HOXC12	chr12_54349650_54349801	1107	0.249164	-0.37	3.3e-01	Click!
HOXC12	chr12_54347104_54347382	1375	0.198326	-0.20	6.0e-01	Click!
HOXD12	chr2_176961450_176961876	2795	0.115168	0.49	1.8e-01	Click!
HOXD12	chr2_176961922_176962434	2280	0.133461	-0.28	4.7e-01	Click!
HOXD12	chr2_176961216_176961367	3167	0.106697	0.16	6.8e-01	Click!

Activity of the HOXC12_HOXD12 motif across conditions

Conditions sorted by the z-value of the HOXC12_HOXD12 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_161992740_161992891	0.73	OLFML2B	olfactomedin-like 2B	615	0.79
chr4_119755136_119755442	0.69	SEC24D	SEC24 family member D	2004	0.43
chr3_27523015_27523166	0.62	SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	2748	0.29
chr3_106063956_106064334	0.58	ENSG00000200610	.	170599	0.04
chr2_177001025_177001411	0.55	HOXD3	homeobox D3	467	0.41
chr8_93071638_93071789	0.52	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	3478	0.37
chr16_4069505_4069681	0.52	RP11-462G12.4		12420	0.19
chr5_78910199_78910447	0.50	PAPD4	PAP associated domain containing 4	1927	0.42
chr10_17275327_17275794	0.48	RP11-124N14.3		1272	0.37
chr13_80824234_80824440	0.46	SPRY2	sprouty homolog 2 (Drosophila)	89457	0.1
chr4_5709733_5710324	0.46	EVC2	Ellis van Creveld syndrome 2	266	0.93
chr11_121970307_121971111	0.44	ENSG00000207971	.	157	0.79
chr1_78471558_78472034	0.44	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	1258	0.34
chr3_112358713_112358917	0.44	CCDC80	coiled-coil domain containing 80	1301	0.54
chr12_12473193_12473372	0.44	MANSC1	MANSC domain containing 1	18326	0.15
chr15_25123597_25123815	0.43	ENSG00000238615	.	15188	0.12
chr12_100305238_100305389	0.43	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	72702	0.11
chr16_86613931_86614082	0.42	FOXL1	forkhead box L1	1891	0.3
chr14_55077134_55077351	0.42	SAMD4A	sterile alpha motif domain containing 4A	42605	0.17
chr15_99789344_99789838	0.42	TTC23	tetratricopeptide repeat domain 23	145	0.94
chr1_193153819_193153970	0.42	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	1890	0.36
chr5_10474837_10474988	0.41	RP11-1C1.7		4571	0.18
chr7_38668604_38668755	0.41	AMPH	amphiphysin	2341	0.39
chr21_36625519_36625670	0.39	RUNX1	runt-related transcription factor 1	203953	0.03
chr2_151467111_151467262	0.39	RND3	Rho family GTPase 3	71661	0.14
chr5_66256594_66256761	0.39	MAST4	microtubule associated serine/threonine kinase family member 4	1861	0.46
chr2_163098757_163099006	0.38	FAP	fibroblast activation protein, alpha	677	0.75
chr5_33890564_33890715	0.38	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1407	0.4
chr8_90776220_90776452	0.38	RIPK2	receptor-interacting serine-threonine kinase 2	6274	0.32
chr14_45711437_45711895	0.38	MIS18BP1	MIS18 binding protein 1	10714	0.2
chr7_94026049_94026200	0.38	COL1A2	collagen, type I, alpha 2	2251	0.42
chr11_132813237_132813595	0.37	OPCML	opioid binding protein/cell adhesion molecule-like	150	0.98
chr14_54816467_54816618	0.37	CDKN3	cyclin-dependent kinase inhibitor 3	47131	0.17
chr16_31022230_31022574	0.37	STX1B	syntaxin 1B	453	0.64
chr15_49717369_49717525	0.37	FGF7	fibroblast growth factor 7	1990	0.39
chr14_51242372_51242693	0.37	NIN	ninein (GSK3B interacting protein)	9019	0.17
chr1_51972253_51972404	0.37	RP11-191G24.1		11653	0.15
chr11_121967218_121967559	0.37	ENSG00000207971	.	3164	0.21
chr13_77403994_77404145	0.36	KCTD12	potassium channel tetramerization domain containing 12	56456	0.13
chr1_240207824_240208231	0.36	FMN2	formin 2	30379	0.22
chr1_231002708_231002859	0.36	C1orf198	chromosome 1 open reading frame 198	1616	0.28
chr15_55881115_55881360	0.36	PYGO1	pygopus family PHD finger 1	92	0.98
chr7_120664009_120664211	0.36	CPED1	cadherin-like and PC-esterase domain containing 1	34434	0.16
chr8_61048624_61048775	0.36	CA8	carbonic anhydrase VIII	145272	0.05
chr1_95388573_95389173	0.35	CNN3	calponin 3, acidic	2464	0.27
chr8_93068476_93068627	0.35	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	6640	0.32
chr6_103134414_103134565	0.35	GRIK2	glutamate receptor, ionotropic, kainate 2	868244	0.0
chr5_169407172_169407407	0.35	FAM196B	family with sequence similarity 196, member B	455	0.87
chr7_114055343_114055580	0.35	FOXP2	forkhead box P2	83	0.98
chr12_13328389_13328540	0.35	EMP1	epithelial membrane protein 1	21186	0.21
chr8_116674347_116674529	0.35	TRPS1	trichorhinophalangeal syndrome I	533	0.88
chr10_100027009_100027207	0.35	LOXL4	lysyl oxidase-like 4	899	0.63
chr1_29503469_29503620	0.35	SRSF4	serine/arginine-rich splicing factor 4	4866	0.18
chr3_194409728_194410184	0.34	FAM43A	family with sequence similarity 43, member A	3334	0.19
chr7_94024612_94024816	0.34	COL1A2	collagen, type I, alpha 2	841	0.73
chr13_76324065_76324216	0.34	LMO7	LIM domain 7	10363	0.26
chr12_104443529_104443940	0.34	GLT8D2	glycosyltransferase 8 domain containing 2	180	0.94
chr16_22706573_22706828	0.34	ENSG00000265058	.	58635	0.13
chr9_17017802_17018053	0.34	ENSG00000241152	.	35972	0.22
chr17_45352801_45353270	0.34	ENSG00000238419	.	16249	0.13
chr13_98796347_98796640	0.33	FARP1	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	759	0.68
chrX_74966247_74966822	0.33	MAGEE2	melanoma antigen family E, 2	38545	0.23
chr21_28339057_28339347	0.33	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	370	0.89
chr1_247611615_247612128	0.33	OR2B11	olfactory receptor, family 2, subfamily B, member 11	3437	0.2
chr7_23098334_23098498	0.33	FAM126A	family with sequence similarity 126, member A	44667	0.15
chr2_177022618_177022769	0.33	HOXD3	homeobox D3	2926	0.11
chr10_17151338_17151489	0.33	CUBN	cubilin (intrinsic factor-cobalamin receptor)	18423	0.23
chr10_70321971_70322188	0.33	TET1	tet methylcytosine dioxygenase 1	1666	0.36
chr2_225846726_225846877	0.32	ENSG00000263828	.	28456	0.22
chr20_10701589_10701740	0.32	JAG1	jagged 1	46970	0.17
chr1_88150357_88150552	0.32	ENSG00000199318	.	231398	0.02
chr13_74636535_74636686	0.32	KLF12	Kruppel-like factor 12	67424	0.15
chr4_113831338_113831756	0.31	RP11-119H12.6		28061	0.21
chr3_120168336_120168615	0.31	FSTL1	follistatin-like 1	1363	0.54
chr2_176995490_176995715	0.31	HOXD8	homeobox D8	517	0.55
chr2_227653875_227654026	0.31	IRS1	insulin receptor substrate 1	10525	0.21
chr16_68440497_68440679	0.31	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	34427	0.11
chr16_29230121_29230272	0.31	RP11-231C14.6		93475	0.05
chr7_18810301_18810537	0.31	ENSG00000222164	.	37483	0.22
chr7_134397415_134397661	0.31	CALD1	caldesmon 1	31465	0.2
chr3_191070684_191070835	0.31	UTS2B	urotensin 2B	22434	0.2
chr11_11485098_11485249	0.31	RP11-483L5.1		106458	0.06
chrX_34671991_34672311	0.30	TMEM47	transmembrane protein 47	3254	0.41
chr12_66093282_66093481	0.30	HMGA2	high mobility group AT-hook 2	124530	0.05
chr1_92350235_92350616	0.30	TGFBR3	transforming growth factor, beta receptor III	1241	0.52
chr1_205818632_205818989	0.30	PM20D1	peptidase M20 domain containing 1	435	0.83
chr18_55448427_55448643	0.30	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	21792	0.18
chr4_53411844_53412014	0.30	ENSG00000239068	.	35750	0.18
chr3_29325145_29325351	0.30	RBMS3	RNA binding motif, single stranded interacting protein 3	2141	0.37
chr17_66706567_66706718	0.30	ENSG00000263690	.	56058	0.14
chr2_149574916_149575083	0.30	ENSG00000222126	.	8405	0.24
chr11_121800761_121801203	0.30	ENSG00000252556	.	74081	0.11
chr9_73205228_73205379	0.30	ENSG00000272232	.	10926	0.28
chr8_113763690_113763841	0.29	CSMD3	CUB and Sushi multiple domains 3	61494	0.15
chr5_35130063_35130359	0.29	PRLR	prolactin receptor	235	0.95
chr4_114679710_114679861	0.29	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	2439	0.44
chr7_90331083_90331234	0.29	CDK14	cyclin-dependent kinase 14	7422	0.29
chr15_48201872_48202023	0.29	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	143170	0.04
chr8_13371978_13372169	0.29	DLC1	deleted in liver cancer 1	201	0.95
chr18_24059631_24059830	0.29	KCTD1	potassium channel tetramerization domain containing 1	67233	0.12
chr15_71626398_71626549	0.29	RP11-592N21.2		8190	0.3
chr12_91721216_91721367	0.29	DCN	decorin	144391	0.05
chr12_118813023_118813174	0.29	SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	1087	0.54
chr6_143014732_143015018	0.29	RP1-67K17.3		54705	0.17
chr2_181560059_181560213	0.28	ENSG00000264976	.	78203	0.12
chr10_6807939_6808090	0.28	PRKCQ	protein kinase C, theta	185751	0.03
chr2_38977227_38977516	0.28	SRSF7	serine/arginine-rich splicing factor 7	665	0.58
chr3_156396529_156396802	0.28	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	2212	0.34
chr11_133917712_133918072	0.28	JAM3	junctional adhesion molecule 3	20928	0.21
chr8_105479291_105479486	0.28	DPYS	dihydropyrimidinase	107	0.96
chr10_118608485_118608929	0.28	ENO4	enolase family member 4	316	0.65
chr3_72202008_72202197	0.28	ENSG00000212070	.	109477	0.07
chr5_32442900_32443051	0.28	ZFR	zinc finger RNA binding protein	1892	0.38
chr2_134484670_134484906	0.28	ENSG00000200708	.	131126	0.05
chr2_164734018_164734360	0.28	FIGN	fidgetin	141667	0.05
chr16_21943276_21943517	0.28	RP11-645C24.2		16051	0.15
chr21_34181326_34181477	0.28	C21orf62	chromosome 21 open reading frame 62	1373	0.37
chr5_123121441_123121770	0.28	CSNK1G3	casein kinase 1, gamma 3	197486	0.03
chr16_73809854_73810059	0.28	PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	520717	0.0
chr4_48572788_48572939	0.28	ENSG00000251722	.	3674	0.25
chr1_223902537_223902699	0.27	CAPN2	calpain 2, (m/II) large subunit	2584	0.3
chr16_17839007_17839172	0.27	XYLT1	xylosyltransferase I	274351	0.02
chr16_51147416_51147567	0.27	AC009166.5		35659	0.19
chr5_88081506_88081673	0.27	MEF2C	myocyte enhancer factor 2C	38016	0.18
chr1_236922800_236922951	0.27	ACTN2	actinin, alpha 2	28325	0.2
chrX_46407651_46407802	0.27	ZNF674	zinc finger protein 674	2850	0.28
chr20_62451041_62451439	0.27	ZBTB46	zinc finger and BTB domain containing 46	11327	0.09
chr12_122048138_122048289	0.27	ENSG00000252393	.	5406	0.19
chr1_211749324_211749475	0.27	SLC30A1	solute carrier family 30 (zinc transporter), member 1	2685	0.27
chr10_133793669_133793880	0.27	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	1653	0.46
chr2_111434839_111435049	0.27	BUB1	BUB1 mitotic checkpoint serine/threonine kinase	666	0.76
chr13_80909879_80910030	0.27	SPRY2	sprouty homolog 2 (Drosophila)	3840	0.32
chr19_23258822_23259008	0.27	ZNF730	zinc finger protein 730	903	0.69
chr4_56685755_56685906	0.27	ENSG00000251923	.	21028	0.18
chr20_31273739_31274060	0.27	COMMD7	COMM domain containing 7	57313	0.1
chr10_115141660_115142454	0.27	ENSG00000238380	.	28873	0.24
chr4_183066487_183066672	0.27	AC108142.1		177	0.77
chr10_131404305_131404456	0.27	AL355531.2	Uncharacterized protein	94855	0.08
chr7_100777700_100777901	0.27	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	7421	0.1
chr2_156015694_156015845	0.27	ENSG00000223197	.	69719	0.14
chr6_18596391_18596542	0.27	ENSG00000207775	.	24451	0.27
chr1_230358262_230358466	0.26	RP5-956O18.2		45865	0.16
chr10_63815746_63815944	0.26	ARID5B	AT rich interactive domain 5B (MRF1-like)	6875	0.28
chr16_11444934_11445085	0.26	RP11-485G7.6		1831	0.18
chr15_80364981_80365385	0.26	ZFAND6	zinc finger, AN1-type domain 6	251	0.94
chr15_96878987_96879612	0.26	ENSG00000222651	.	2809	0.21
chr18_59003210_59003361	0.26	CDH20	cadherin 20, type 2	1779	0.49
chr8_108470289_108470492	0.26	ANGPT1	angiopoietin 1	36833	0.24
chr8_123439435_123439791	0.26	ENSG00000238901	.	243917	0.02
chr8_52809581_52809732	0.26	RP11-110G21.2		722	0.58
chr8_67445859_67446056	0.26	ENSG00000206949	.	32411	0.15
chr6_11230027_11230357	0.26	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	2699	0.33
chr18_13725459_13725610	0.26	FAM210A	family with sequence similarity 210, member A	1025	0.35
chr18_59949352_59949799	0.26	RP11-173A16.1		18656	0.15
chr6_52170291_52170590	0.26	MCM3	minichromosome maintenance complex component 3	20805	0.19
chr8_84428926_84429077	0.26	RALYL	RALY RNA binding protein-like	666021	0.0
chr9_97768076_97768588	0.26	C9orf3	chromosome 9 open reading frame 3	1054	0.55
chr19_37064628_37064871	0.26	AC092295.7		310	0.66
chr4_17513834_17514187	0.26	QDPR	quinoid dihydropteridine reductase	153	0.95
chr12_21809355_21809506	0.26	LDHB	lactate dehydrogenase B	866	0.6
chr3_170147186_170147337	0.26	CLDN11	claudin 11	10406	0.26
chr21_32931442_32932281	0.25	AP000251.3		303	0.71
chr12_29734516_29734686	0.25	TMTC1	transmembrane and tetratricopeptide repeat containing 1	22556	0.22
chr2_86332162_86332313	0.25	POLR1A	polymerase (RNA) I polypeptide A, 194kDa	1041	0.34
chr12_80329810_80330005	0.25	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	667	0.6
chr9_90812890_90813286	0.25	ENSG00000252299	.	176096	0.03
chr17_636232_637034	0.25	FAM57A	family with sequence similarity 57, member A	268	0.88
chr21_36256046_36256553	0.25	RUNX1	runt-related transcription factor 1	3181	0.38
chr4_6201946_6202294	0.25	JAKMIP1	janus kinase and microtubule interacting protein 1	162	0.97
chr7_137026886_137027037	0.25	PTN	pleiotrophin	1559	0.52
chr13_32520726_32520877	0.25	EEF1DP3	eukaryotic translation elongation factor 1 delta pseudogene 3	5916	0.29
chr16_4000635_4001034	0.25	RP11-462G12.1		389	0.84
chr17_15162603_15162754	0.25	RP11-849N15.1		1654	0.29
chr5_73839584_73839978	0.25	HEXB	hexosaminidase B (beta polypeptide)	96067	0.08
chr22_19511259_19511486	0.25	CLDN5	claudin 5	1534	0.33
chr7_72933105_72933537	0.25	BAZ1B	bromodomain adjacent to zinc finger domain, 1B	3281	0.19
chr7_112759172_112759323	0.25	LINC00998	long intergenic non-protein coding RNA 998	579	0.78
chr12_104880345_104880496	0.25	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	29641	0.22
chr8_29970332_29970518	0.25	LEPROTL1	leptin receptor overlapping transcript-like 1	10969	0.15
chr17_46651672_46651823	0.25	HOXB3	homeobox B3	102	0.91
chr3_59996849_59997073	0.25	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	39378	0.24
chr4_17812934_17813275	0.25	NCAPG	non-SMC condensin I complex, subunit G	579	0.52
chr2_66808823_66809387	0.25	MEIS1	Meis homeobox 1	73046	0.12
chr5_14446559_14446710	0.25	TRIO	trio Rho guanine nucleotide exchange factor	41923	0.2
chr9_129388558_129388709	0.25	LMX1B	LIM homeobox transcription factor 1, beta	11885	0.16
chr16_53243944_53244222	0.25	CHD9	chromodomain helicase DNA binding protein 9	1720	0.39
chr2_219646650_219647418	0.25	CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	555	0.7
chr8_123701726_123701877	0.25	ENSG00000238901	.	18271	0.25
chr3_175389807_175390608	0.25	ENSG00000201648	.	62940	0.12
chr1_227501319_227501470	0.25	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	3489	0.36
chr6_161469926_161470077	0.25	MAP3K4	mitogen-activated protein kinase kinase kinase 4	26775	0.22
chr10_14050350_14050950	0.25	FRMD4A	FERM domain containing 4A	118	0.97
chr4_174103125_174103453	0.24	RP11-10K16.1		12486	0.18
chr11_85396604_85397203	0.24	CCDC89	coiled-coil domain containing 89	417	0.8
chr18_33737848_33738011	0.24	ELP2	elongator acetyltransferase complex subunit 2	28042	0.14
chr2_225811426_225811868	0.24	DOCK10	dedicator of cytokinesis 10	135	0.98
chr6_113700515_113700666	0.24	ENSG00000222677	.	135599	0.05
chr17_64350080_64350280	0.24	ENSG00000244044	.	9967	0.22
chr1_68667966_68668117	0.24	ENSG00000221203	.	18748	0.2
chr18_55466126_55466277	0.24	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	4126	0.27

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC12_HOXD12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.2	1.0	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.1	0.5	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.5	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.3	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.3	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1	0.3	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.1	0.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.7	GO:0060325	face morphogenesis(GO:0060325)
0.1	0.5	GO:0060216	definitive hemopoiesis(GO:0060216)
0.1	0.2	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.2	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.1	0.2	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.2	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.1	0.1	GO:0021825	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.1	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.1	0.3	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.2	GO:0051608	histamine transport(GO:0051608)
0.1	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.2	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.3	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.3	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.3	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.1	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.2	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.2	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.6	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.0	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.3	GO:0008595	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132) metaphase(GO:0051323)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.2	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.4	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.2	GO:0006777	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.2	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.4	GO:0043631	RNA polyadenylation(GO:0043631)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.2	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.2	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0071504	cellular response to heparin(GO:0071504)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.4	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.2	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.0	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.3	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0060526	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.1	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.3	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.5	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.2	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.1	GO:0021955	central nervous system neuron axonogenesis(GO:0021955)
0.0	0.4	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.0	GO:0006998	nuclear envelope organization(GO:0006998)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.0	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0001714	endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) regulation of gastrulation(GO:0010470) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.0	GO:0010755	regulation of plasminogen activation(GO:0010755)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.0	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0044550	secondary metabolite biosynthetic process(GO:0044550)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.4	GO:0090090	negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0	0.2	GO:0009268	response to pH(GO:0009268)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0031058	positive regulation of histone modification(GO:0031058)
0.0	0.1	GO:0048266	behavioral response to pain(GO:0048266)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.3	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0	0.2	GO:0006949	syncytium formation(GO:0006949)
0.0	0.0	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.0	GO:0003079	obsolete positive regulation of natriuresis(GO:0003079)
0.0	0.0	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.4	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0003211	cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.0	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.0	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0010171	body morphogenesis(GO:0010171)
0.0	0.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.2	GO:0008038	neuron recognition(GO:0008038)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.0	GO:0010800	regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.0	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:0071072	regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0008210	estrogen metabolic process(GO:0008210)
0.0	0.2	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.1	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.1	GO:0051602	response to electrical stimulus(GO:0051602)
0.0	0.1	GO:0070076	histone lysine demethylation(GO:0070076)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:0045843	negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.0	0.0	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.3	GO:0071438	invadopodium membrane(GO:0071438)
0.1	0.3	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.7	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.3	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	0.2	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.1	0.5	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.3	GO:0000796	condensin complex(GO:0000796)
0.1	0.2	GO:0032591	dendritic spine membrane(GO:0032591)
0.1	0.2	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.4	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.3	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.2	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.7	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	0.0	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0045120	pronucleus(GO:0045120)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1	0.3	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.5	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	0.3	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.4	GO:0004985	opioid receptor activity(GO:0004985)
0.1	0.2	GO:0005113	patched binding(GO:0005113)
0.1	0.2	GO:0016362	activin receptor activity, type II(GO:0016362)
0.1	0.5	GO:0043274	phospholipase binding(GO:0043274)
0.1	0.3	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.1	0.1	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	0.6	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.4	GO:0050811	GABA receptor binding(GO:0050811)
0.1	0.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.3	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.4	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0004844	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0031779	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.3	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.3	GO:0005234	extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.3	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.2	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.3	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0019238	cyclohydrolase activity(GO:0019238)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.0	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.6	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.0	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	1.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.2	GO:0045296	cadherin binding(GO:0045296)
0.0	0.0	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.7	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	PID INSULIN PATHWAY	Insulin Pathway
0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.5	PID AURORA B PATHWAY	Aurora B signaling
0.4	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.5	PID FGF PATHWAY	FGF signaling pathway
0.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	PID PLK1 PATHWAY	PLK1 signaling events
0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.1	0.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.5	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.4	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.0	REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	Genes involved in Formation of the HIV-1 Early Elongation Complex
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.3	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.0	0.4	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.2	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.3	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)