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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXD1

Z-value: 0.86

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Transcription factors associated with HOXD1

Gene Symbol	Gene ID	Gene Info
HOXD1 Ensembl NCBI GeneCards UniProt	ENSG00000128645.11	HOXD1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXD1	chr2_177053046_177053572	2	0.507034	-0.31	4.2e-01	Click!

Activity of the HOXD1 motif across conditions

Conditions sorted by the z-value of the HOXD1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_19815653_19816006	1.13	SH3KBP1	SH3-domain kinase binding protein 1	2040	0.46
chr21_15917916_15918619	0.80	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr2_193992778_193992929	0.73	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2	932418	0.0
chr17_37933702_37934037	0.63	IKZF3	IKAROS family zinc finger 3 (Aiolos)	609	0.66
chr14_22947593_22947744	0.63	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr13_99957828_99957979	0.61	GPR183	G protein-coupled receptor 183	1756	0.38
chr3_186745077_186745229	0.60	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	1882	0.42
chrX_28529887_28530038	0.59	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	75554	0.12
chr1_29253817_29254129	0.55	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chrX_31453419_31453570	0.53	ENSG00000252903	.	87185	0.1
chr1_66806017_66806168	0.53	PDE4B	phosphodiesterase 4B, cAMP-specific	8220	0.31
chr4_144312492_144312643	0.52	GAB1	GRB2-associated binding protein 1	96	0.98
chr3_108543496_108543820	0.52	TRAT1	T cell receptor associated transmembrane adaptor 1	2039	0.42
chr17_75456326_75456913	0.50	SEPT9	septin 9	4171	0.18
chr13_40532306_40532606	0.49	ENSG00000212553	.	101092	0.08
chr21_32555155_32555306	0.48	TIAM1	T-cell lymphoma invasion and metastasis 1	52691	0.16
chrX_78400540_78401325	0.47	GPR174	G protein-coupled receptor 174	25537	0.27
chr4_25865391_25865542	0.47	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)	84	0.98
chr5_126094279_126094440	0.47	ENSG00000252185	.	3250	0.29
chr7_106822662_106822813	0.47	HBP1	HMG-box transcription factor 1	2374	0.31
chr15_60874237_60874501	0.46	RORA	RAR-related orphan receptor A	10371	0.22
chr2_235359483_235359634	0.46	ARL4C	ADP-ribosylation factor-like 4C	45686	0.21
chr4_143321296_143321548	0.46	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30990	0.26
chr9_80524074_80524374	0.45	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	86309	0.1
chr3_135909805_135909956	0.45	MSL2	male-specific lethal 2 homolog (Drosophila)	3516	0.32
chr2_191274024_191274175	0.45	MFSD6	major facilitator superfamily domain containing 6	1018	0.56
chr14_22993528_22993679	0.44	TRAJ15	T cell receptor alpha joining 15	4977	0.12
chr14_70111468_70111619	0.44	KIAA0247	KIAA0247	33230	0.18
chr5_118653769_118653920	0.43	ENSG00000243333	.	11518	0.19
chr1_225610206_225610357	0.43	LBR	lamin B receptor	5318	0.2
chr7_26141262_26141558	0.42	ENSG00000266430	.	41451	0.15
chr10_17701952_17702103	0.42	STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	15763	0.14
chr12_47600587_47601314	0.42	PCED1B	PC-esterase domain containing 1B	9102	0.22
chr13_41555714_41555943	0.41	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr1_234544831_234544982	0.40	COA6	cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)	35459	0.12
chr11_58777091_58777242	0.39	RP11-142C4.6		30408	0.16
chr1_192546230_192546423	0.39	RGS1	regulator of G-protein signaling 1	1423	0.45
chr12_1434091_1434389	0.39	RP5-951N9.2		60759	0.12
chr5_35863316_35863652	0.39	IL7R	interleukin 7 receptor	6490	0.21
chr6_130391698_130391967	0.39	L3MBTL3	l(3)mbt-like 3 (Drosophila)	50130	0.15
chr4_39032194_39032374	0.39	TMEM156	transmembrane protein 156	1757	0.38
chr1_186291714_186291865	0.38	ENSG00000202025	.	10729	0.17
chr4_99565395_99565546	0.38	TSPAN5	tetraspanin 5	13316	0.22
chr8_27131821_27132033	0.36	STMN4	stathmin-like 4	15990	0.18
chr6_154568354_154568864	0.36	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chr3_40518130_40518400	0.36	ZNF619	zinc finger protein 619	339	0.84
chr21_25260128_25260279	0.36	ENSG00000199698	.	455601	0.01
chrX_88218836_88218987	0.36	CPXCR1	CPX chromosome region, candidate 1	216675	0.02
chr15_93431332_93431756	0.35	CHD2	chromodomain helicase DNA binding protein 2	5018	0.2
chr1_160614457_160614608	0.35	SLAMF1	signaling lymphocytic activation molecule family member 1	2279	0.26
chr12_12510418_12511218	0.34	LOH12CR1	loss of heterozygosity, 12, chromosomal region 1	466	0.63
chr11_128894218_128894369	0.34	ARHGAP32	Rho GTPase activating protein 32	205	0.94
chr4_36243817_36244102	0.34	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1602	0.35
chr15_96817385_96817602	0.34	NR2F2-AS1	NR2F2 antisense RNA 1	1732	0.37
chr7_106507057_106507208	0.34	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr5_61577589_61577740	0.33	KIF2A	kinesin heavy chain member 2A	24325	0.24
chr6_106972751_106973424	0.33	AIM1	absent in melanoma 1	13357	0.2
chr15_50648671_50648965	0.32	ENSG00000244879	.	150	0.91
chr2_238893215_238893433	0.32	UBE2F	ubiquitin-conjugating enzyme E2F (putative)	11587	0.2
chr13_21050204_21050392	0.32	ENSG00000263978	.	42313	0.15
chr6_41855450_41855601	0.31	USP49	ubiquitin specific peptidase 49	458	0.75
chr3_95425254_95425405	0.31	ENSG00000221477	.	460417	0.01
chr7_156761668_156761819	0.31	NOM1	nucleolar protein with MIF4G domain 1	19326	0.16
chr4_154411300_154411567	0.31	KIAA0922	KIAA0922	23932	0.22
chr14_34521580_34521731	0.31	EGLN3-AS1	EGLN3 antisense RNA 1	12352	0.27
chr7_37011253_37011404	0.31	ELMO1	engulfment and cell motility 1	13337	0.2
chr6_11727810_11727987	0.31	ADTRP	androgen-dependent TFPI-regulating protein	7991	0.25
chr21_45341679_45341830	0.31	ENSG00000199598	.	1972	0.29
chr7_17039488_17039788	0.30	AGR3	anterior gradient 3	118027	0.06
chr13_45991538_45991858	0.30	SLC25A30	solute carrier family 25, member 30	811	0.6
chr2_68379959_68380110	0.30	WDR92	WD repeat domain 92	4571	0.18
chr2_213997408_213997559	0.30	IKZF2	IKAROS family zinc finger 2 (Helios)	15870	0.28
chrX_78403286_78403508	0.30	GPR174	G protein-coupled receptor 174	23072	0.28
chr4_140587624_140588180	0.30	MGST2	microsomal glutathione S-transferase 2	913	0.61
chr1_158983210_158983361	0.30	IFI16	interferon, gamma-inducible protein 16	1186	0.5
chr12_46062870_46063096	0.29	ARID2	AT rich interactive domain 2 (ARID, RFX-like)	60465	0.15
chrY_1551045_1551310	0.29	NA	NA	> 10⁶	NA
chr10_129861850_129862130	0.29	PTPRE	protein tyrosine phosphatase, receptor type, E	16156	0.26
chr4_105887659_105887892	0.29	ENSG00000251906	.	8044	0.31
chr3_156400615_156400766	0.28	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	1735	0.41
chr13_97879341_97880219	0.28	MBNL2	muscleblind-like splicing regulator 2	5171	0.33
chr12_14924776_14925101	0.28	HIST4H4	histone cluster 4, H4	873	0.43
chr10_90752530_90752985	0.28	ACTA2	actin, alpha 2, smooth muscle, aorta	1610	0.28
chr21_36367168_36367319	0.28	RUNX1	runt-related transcription factor 1	54219	0.18
chr1_206646546_206646697	0.28	IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	2783	0.21
chr16_71935673_71935824	0.28	IST1	increased sodium tolerance 1 homolog (yeast)	6256	0.13
chr10_70850849_70851349	0.28	SRGN	serglycin	3225	0.25
chr11_20388995_20389167	0.27	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa	3355	0.31
chr9_24621401_24621552	0.27	IZUMO3	IZUMO family member 3	75532	0.13
chr18_2605370_2605521	0.27	NDC80	NDC80 kinetochore complex component	5335	0.16
chr5_68338922_68339492	0.27	SLC30A5	solute carrier family 30 (zinc transporter), member 5	50266	0.12
chr3_108549304_108549455	0.27	TRAT1	T cell receptor associated transmembrane adaptor 1	7760	0.27
chr18_60982497_60982692	0.27	RP11-28F1.2		1279	0.41
chr11_88068800_88069370	0.27	CTSC	cathepsin C	1816	0.49
chr8_103807257_103807446	0.27	ENSG00000266799	.	61404	0.1
chrX_117750069_117750220	0.27	ENSG00000206862	.	46666	0.16
chr4_36245078_36245884	0.27	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr1_246488003_246488154	0.26	SMYD3-IT1	SMYD3 intronic transcript 1 (non-protein coding)	2338	0.35
chrX_23969833_23969984	0.26	CXorf58	chromosome X open reading frame 58	41408	0.14
chr6_98593876_98594027	0.26	ENSG00000238367	.	121544	0.07
chr3_171848594_171848745	0.26	FNDC3B	fibronectin type III domain containing 3B	3905	0.33
chr10_17548651_17548924	0.26	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	52458	0.13
chr11_128589269_128589524	0.26	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23478	0.17
chrX_78620075_78620267	0.26	ITM2A	integral membrane protein 2A	2685	0.44
chrX_78200973_78201449	0.26	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	293	0.95
chr11_118900356_118900707	0.26	SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	1040	0.25
chr8_66742389_66742540	0.25	PDE7A	phosphodiesterase 7A	8519	0.29
chr14_22461559_22461710	0.25	ENSG00000238634	.	149253	0.04
chr19_48832910_48833240	0.25	EMP3	epithelial membrane protein 3	4210	0.13
chr12_131796680_131796831	0.25	ENSG00000212251	.	12459	0.23
chr7_91705589_91705740	0.25	AKAP9	A kinase (PRKA) anchor protein 9	6212	0.22
chr4_166361643_166362016	0.25	CPE	carboxypeptidase E	22451	0.23
chr15_52844361_52844512	0.25	ARPP19	cAMP-regulated phosphoprotein, 19kDa	5505	0.2
chr6_91004568_91004758	0.24	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	1798	0.43
chr14_90084669_90085459	0.24	FOXN3	forkhead box N3	410	0.78
chr20_25023152_25023303	0.24	ACSS1	acyl-CoA synthetase short-chain family member 1	9888	0.2
chr11_119572371_119572522	0.23	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	26817	0.16
chr9_125662893_125663901	0.23	RC3H2	ring finger and CCCH-type domains 2	3008	0.16
chr12_94805998_94806149	0.23	CCDC41	coiled-coil domain containing 41	47649	0.14
chr3_187492063_187492306	0.23	BCL6	B-cell CLL/lymphoma 6	28669	0.2
chr12_54679325_54679476	0.23	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	3418	0.1
chr6_74231834_74232090	0.23	EEF1A1	eukaryotic translation elongation factor 1 alpha 1	339	0.77
chr1_247553346_247553582	0.23	NLRP3	NLR family, pyrin domain containing 3	25994	0.15
chr6_17972440_17972591	0.23	KIF13A	kinesin family member 13A	15179	0.27
chr5_116293290_116293441	0.23	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	382735	0.01
chr12_64798382_64799443	0.23	XPOT	exportin, tRNA	86	0.97
chr20_48328141_48328292	0.23	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	2199	0.3
chr11_20179312_20179463	0.23	DBX1	developing brain homeobox 1	2483	0.35
chr14_71454929_71455080	0.23	PCNX	pecanex homolog (Drosophila)	24744	0.26
chr17_54857369_54857761	0.23	C17orf67	chromosome 17 open reading frame 67	35685	0.15
chr14_88471433_88472132	0.23	GPR65	G protein-coupled receptor 65	314	0.88
chr17_47766049_47766200	0.23	SPOP	speckle-type POZ protein	10528	0.14
chr12_64852912_64853865	0.22	TBK1	TANK-binding kinase 1	7133	0.2
chr21_16726840_16726991	0.22	ENSG00000212564	.	259687	0.02
chr10_119202905_119203056	0.22	EMX2OS	EMX2 opposite strand/antisense RNA	33704	0.18
chr5_75600050_75600201	0.22	RP11-466P24.6		7162	0.3
chr3_71539044_71539195	0.22	ENSG00000221264	.	52121	0.14
chr12_96794557_96795184	0.22	CDK17	cyclin-dependent kinase 17	532	0.79
chr1_226919798_226919959	0.22	ITPKB	inositol-trisphosphate 3-kinase B	5281	0.26
chr8_42034876_42035027	0.22	AP3M2	adaptor-related protein complex 3, mu 2 subunit	10144	0.16
chr20_3452818_3452969	0.22	ATRN	attractin	1138	0.49
chr11_88087417_88087693	0.22	CTSC	cathepsin C	16600	0.28
chr2_161995560_161995711	0.22	TANK	TRAF family member-associated NFKB activator	2169	0.37
chr6_90066974_90067553	0.22	UBE2J1	ubiquitin-conjugating enzyme E2, J1	4696	0.23
chr6_143179346_143179497	0.21	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	21237	0.25
chr18_9404580_9404814	0.21	TWSG1	twisted gastrulation BMP signaling modulator 1	69849	0.08
chrX_1600809_1601304	0.21	ASMTL	acetylserotonin O-methyltransferase-like	28401	0.16
chrX_18516169_18516320	0.21	CDKL5	cyclin-dependent kinase-like 5	55936	0.14
chr15_29021803_29021954	0.21	RP11-578F21.10		11870	0.15
chr5_110560941_110561277	0.21	CAMK4	calcium/calmodulin-dependent protein kinase IV	1325	0.51
chr10_63753889_63754171	0.21	ARID5B	AT rich interactive domain 5B (MRF1-like)	54940	0.15
chr6_26198173_26198564	0.21	HIST1H3D	histone cluster 1, H3d	890	0.22
chr10_106007564_106007715	0.21	GSTO1	glutathione S-transferase omega 1	6313	0.13
chr1_29254771_29254973	0.21	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	13781	0.18
chr7_104658006_104658503	0.20	KMT2E	lysine (K)-specific methyltransferase 2E	3346	0.19
chr4_100864856_100865007	0.20	DNAJB14	DnaJ (Hsp40) homolog, subfamily B, member 14	2952	0.23
chr4_153268296_153268447	0.20	FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	1587	0.42
chr1_11335043_11335194	0.20	UBIAD1	UbiA prenyltransferase domain containing 1	1127	0.47
chr3_45732221_45732372	0.20	SACM1L	SAC1 suppressor of actin mutations 1-like (yeast)	1345	0.36
chr1_10516682_10516833	0.20	RP5-1113E3.3		1855	0.2
chr15_52023462_52024365	0.20	LYSMD2	LysM, putative peptidoglycan-binding, domain containing 2	6405	0.15
chr10_70230757_70231440	0.20	DNA2	DNA replication helicase/nuclease 2	545	0.71
chr5_74871506_74871657	0.20	CTC-366B18.2		23624	0.14
chr2_113945705_113945856	0.20	PSD4	pleckstrin and Sec7 domain containing 4	8077	0.14
chr16_53133173_53134292	0.20	CHD9	chromodomain helicase DNA binding protein 9	660	0.77
chrX_83325612_83325763	0.20	RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	117228	0.07
chr13_46755198_46755455	0.20	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	1133	0.45
chr2_37576303_37576454	0.19	QPCT	glutaminyl-peptide cyclotransferase	4526	0.2
chr22_17956680_17956831	0.19	CECR2	cat eye syndrome chromosome region, candidate 2	128	0.97
chr2_38822967_38823118	0.19	HNRNPLL	heterogeneous nuclear ribonucleoprotein L-like	4126	0.22
chr8_27223967_27224118	0.19	PTK2B	protein tyrosine kinase 2 beta	14126	0.22
chr17_75178097_75178354	0.19	SEC14L1	SEC14-like 1 (S. cerevisiae)	1106	0.55
chr7_115668295_115668446	0.19	TFEC	transcription factor EC	2425	0.43
chr3_151961363_151961565	0.19	MBNL1	muscleblind-like splicing regulator 1	24365	0.2
chr9_16776546_16776697	0.19	BNC2	basonuclin 2	48409	0.16
chr10_3514525_3515428	0.19	RP11-184A2.3		278283	0.01
chr1_52344711_52345319	0.19	NRD1	nardilysin (N-arginine dibasic convertase)	538	0.71
chr1_90059823_90059974	0.19	LRRC8B	leucine rich repeat containing 8 family, member B	26098	0.15
chr16_79652209_79652360	0.19	MAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	17673	0.26
chr17_76438588_76438739	0.19	AC061992.1	Uncharacterized protein	16254	0.14
chr10_30745504_30745655	0.19	MAP3K8	mitogen-activated protein kinase kinase kinase 8	17828	0.21
chr1_90290694_90290845	0.19	LRRC8D	leucine rich repeat containing 8 family, member D	3289	0.28
chr1_92269176_92269391	0.19	ENSG00000239794	.	26348	0.22
chr1_150294067_150294674	0.19	PRPF3	pre-mRNA processing factor 3	368	0.78
chr8_26184784_26184935	0.19	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	33860	0.18
chr12_92534627_92535592	0.19	C12orf79	chromosome 12 open reading frame 79	1335	0.39
chr8_102786541_102786692	0.19	NCALD	neurocalcin delta	14610	0.25
chr18_74837172_74837323	0.19	MBP	myelin basic protein	2421	0.42
chr1_111420872_111421052	0.19	CD53	CD53 molecule	5186	0.22
chr2_64369947_64371114	0.19	AC074289.1		157	0.93
chr15_43531850_43532099	0.18	ENSG00000202211	.	7904	0.13
chr14_32672268_32672419	0.18	ENSG00000202337	.	132	0.94
chr14_70102783_70102934	0.18	KIAA0247	KIAA0247	24545	0.21
chr5_81762775_81762926	0.18	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like	161684	0.04
chr2_106473228_106473435	0.18	AC009505.2		129	0.97
chr13_28500606_28500757	0.18	PDX1-AS1	PDX1 antisense RNA 1	5140	0.16
chr4_40202041_40202542	0.18	RHOH	ras homolog family member H	327	0.9
chr4_15146065_15146216	0.18	ENSG00000199420	.	50422	0.16
chr2_103506378_103506656	0.18	TMEM182	transmembrane protein 182	128045	0.06
chr5_145562456_145562664	0.18	LARS	leucyl-tRNA synthetase	337	0.89

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0034312	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.2	GO:0060539	diaphragm development(GO:0060539)
0.0	0.2	GO:1904019	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.3	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0018216	peptidyl-arginine methylation(GO:0018216)
0.0	0.1	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.0	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.6	GO:1901185	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0002423	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.3	GO:0006471	protein ADP-ribosylation(GO:0006471)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.2	GO:0030260	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0060285	cilium-dependent cell motility(GO:0060285)
0.0	0.0	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.0	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0007141	male meiosis I(GO:0007141)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.2	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.5	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	1.0	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.0	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.3	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.3	GO:0000049	tRNA binding(GO:0000049)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.0	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	PID IL2 1PATHWAY	IL2-mediated signaling events
0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.5	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	PID ARF6 PATHWAY	Arf6 signaling events
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.5	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.2	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.3	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.2	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)