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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXD11_HOXA11

Z-value: 0.56

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Transcription factors associated with HOXD11_HOXA11

Gene Symbol	Gene ID	Gene Info
HOXD11 Ensembl NCBI GeneCards UniProt	ENSG00000128713.11	HOXD11
HOXA11 Ensembl NCBI GeneCards UniProt	ENSG00000005073.5	HOXA11

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXD11	chr2_176971216_176971605	604	0.475731	-0.67	4.9e-02	Click!
HOXD11	chr2_176971683_176972255	45	0.924613	-0.51	1.6e-01	Click!
HOXD11	chr2_176972526_176972677	587	0.397193	0.17	6.5e-01	Click!
HOXD11	chr2_176969688_176969839	2251	0.126484	-0.08	8.4e-01	Click!
HOXD11	chr2_176969448_176969655	2463	0.118195	-0.04	9.2e-01	Click!

Activity of the HOXD11_HOXA11 motif across conditions

Conditions sorted by the z-value of the HOXD11_HOXA11 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_120168336_120168615	0.31	FSTL1	follistatin-like 1	1363	0.54
chr3_106063956_106064334	0.30	ENSG00000200610	.	170599	0.04
chr4_119755136_119755442	0.28	SEC24D	SEC24 family member D	2004	0.43
chr2_7152423_7152574	0.27	RNF144A	ring finger protein 144A	15427	0.23
chr3_32010054_32010475	0.25	OSBPL10	oxysterol binding protein-like 10	12528	0.2
chr7_14020163_14020323	0.25	ETV1	ets variant 1	5823	0.29
chr12_11325045_11325196	0.24	RP11-785H5.2		1168	0.4
chr3_29327656_29328192	0.24	RBMS3-AS3	RBMS3 antisense RNA 3	4293	0.26
chr8_42063953_42065062	0.23	PLAT	plasminogen activator, tissue	576	0.71
chr4_86700210_86700446	0.23	ARHGAP24	Rho GTPase activating protein 24	469	0.88
chr6_128529501_128529738	0.23	PTPRK	protein tyrosine phosphatase, receptor type, K	113707	0.07
chr6_53928552_53928746	0.23	MLIP-AS1	MLIP antisense RNA 1	15875	0.2
chr7_134465735_134465936	0.22	CALD1	caldesmon 1	1406	0.57
chr13_74636535_74636686	0.22	KLF12	Kruppel-like factor 12	67424	0.15
chr7_116164164_116164509	0.21	CAV1	caveolin 1, caveolae protein, 22kDa	503	0.76
chr2_151385576_151386025	0.21	RND3	Rho family GTPase 3	9725	0.33
chr8_95816216_95816367	0.21	INTS8	integrator complex subunit 8	9248	0.16
chr2_134432207_134432889	0.21	ENSG00000200708	.	78886	0.11
chr10_112258642_112259418	0.21	DUSP5	dual specificity phosphatase 5	1434	0.41
chr7_76958008_76958159	0.21	GSAP	gamma-secretase activating protein	1601	0.47
chr3_183893852_183894003	0.21	AP2M1	adaptor-related protein complex 2, mu 1 subunit	639	0.55
chr8_23711697_23711872	0.20	STC1	stanniocalcin 1	40	0.98
chr5_54456456_54456818	0.20	GPX8	glutathione peroxidase 8 (putative)	639	0.58
chr8_8745358_8745509	0.19	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	5722	0.22
chr7_18549207_18549425	0.19	HDAC9	histone deacetylase 9	380	0.92
chr4_41178199_41178352	0.19	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	38200	0.15
chr17_15281303_15281454	0.19	ENSG00000239888	.	30323	0.15
chr5_110846365_110846666	0.18	STARD4-AS1	STARD4 antisense RNA 1	1409	0.37
chr5_54456050_54456451	0.18	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr1_218521749_218522027	0.18	TGFB2	transforming growth factor, beta 2	2311	0.31
chr16_83377985_83378136	0.18	RP11-543N12.1		53532	0.15
chr5_50040977_50041222	0.18	PARP8	poly (ADP-ribose) polymerase family, member 8	77708	0.12
chr2_160291322_160291473	0.18	BAZ2B	bromodomain adjacent to zinc finger domain, 2B	1936	0.41
chr7_134464463_134465343	0.18	CALD1	caldesmon 1	474	0.89
chr5_155754820_155754971	0.18	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	1128	0.68
chr14_51242372_51242693	0.18	NIN	ninein (GSK3B interacting protein)	9019	0.17
chr7_94029074_94029225	0.17	COL1A2	collagen, type I, alpha 2	5276	0.3
chr8_49292577_49292728	0.17	ENSG00000252710	.	72062	0.13
chr5_35130063_35130359	0.17	PRLR	prolactin receptor	235	0.95
chr15_71054590_71054766	0.17	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	1091	0.55
chr8_16612533_16612758	0.17	ENSG00000264092	.	108360	0.07
chr4_138452878_138453572	0.17	PCDH18	protocadherin 18	340	0.94
chrX_43832059_43832293	0.17	NDP	Norrie disease (pseudoglioma)	574	0.81
chr15_61520624_61520983	0.16	RORA	RAR-related orphan receptor A	715	0.73
chr15_25915762_25916070	0.16	ATP10A	ATPase, class V, type 10A	24056	0.19
chr10_133793669_133793880	0.16	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	1653	0.46
chr13_36047635_36048256	0.16	MAB21L1	mab-21-like 1 (C. elegans)	2887	0.26
chr3_112358713_112358917	0.16	CCDC80	coiled-coil domain containing 80	1301	0.54
chr8_58715313_58715521	0.16	FAM110B	family with sequence similarity 110, member B	191696	0.03
chr1_92329705_92329906	0.16	TGFBR3	transforming growth factor, beta receptor III	2655	0.31
chr3_49538097_49538499	0.16	DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	30546	0.11
chr17_40561693_40562104	0.16	ENSG00000221020	.	10871	0.11
chr20_50550896_50551117	0.16	ENSG00000263659	.	6366	0.22
chr7_10491618_10491769	0.16	ENSG00000212422	.	229269	0.02
chr7_121514140_121514423	0.16	PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	866	0.74
chr1_178310607_178310919	0.16	RASAL2	RAS protein activator like 2	157	0.97
chr13_50649761_50650212	0.16	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	6321	0.18
chr2_207873339_207873490	0.16	CPO	carboxypeptidase O	69136	0.11
chr16_80181289_80181449	0.15	DYNLRB2	dynein, light chain, roadblock-type 2	393262	0.01
chr17_46654170_46654895	0.15	HOXB3	homeobox B3	2094	0.12
chr10_17275327_17275794	0.15	RP11-124N14.3		1272	0.37
chr1_88150758_88150976	0.15	ENSG00000199318	.	231811	0.02
chr9_20570670_20570821	0.15	ENSG00000252324	.	5471	0.24
chr7_82072002_82072462	0.15	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	799	0.78
chr4_38870502_38870773	0.15	ENSG00000207944	.	984	0.38
chr10_17151338_17151489	0.15	CUBN	cubilin (intrinsic factor-cobalamin receptor)	18423	0.23
chr11_31826043_31826338	0.15	PAX6	paired box 6	2279	0.32
chr6_122791067_122791230	0.15	SERINC1	serine incorporator 1	1819	0.33
chr8_22342638_22342826	0.15	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	9627	0.15
chr13_98859156_98859307	0.15	ENSG00000263399	.	1547	0.31
chr22_29107845_29108091	0.15	CHEK2	checkpoint kinase 2	25	0.97
chr4_38754112_38754445	0.15	ENSG00000222230	.	6235	0.19
chr17_45352801_45353270	0.15	ENSG00000238419	.	16249	0.13
chr1_57042188_57042339	0.15	PPAP2B	phosphatidic acid phosphatase type 2B	2978	0.37
chr13_47470589_47471243	0.15	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	253	0.95
chr1_240262074_240262225	0.15	FMN2	formin 2	6969	0.27
chr8_128751469_128751888	0.15	MYC	v-myc avian myelocytomatosis viral oncogene homolog	3201	0.34
chr16_4069505_4069681	0.15	RP11-462G12.4		12420	0.19
chr10_33239282_33239433	0.15	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	5234	0.31
chr11_132813237_132813595	0.15	OPCML	opioid binding protein/cell adhesion molecule-like	150	0.98
chr6_45523951_45524153	0.14	ENSG00000252738	.	89789	0.09
chr4_53411844_53412014	0.14	ENSG00000239068	.	35750	0.18
chr17_57860675_57860960	0.14	RP11-619I22.1		1357	0.39
chr8_108441987_108442138	0.14	ANGPT1	angiopoietin 1	65161	0.15
chr6_26743586_26743955	0.14	ZNF322	zinc finger protein 322	83790	0.08
chr3_175389807_175390608	0.14	ENSG00000201648	.	62940	0.12
chr3_56501298_56501701	0.14	ERC2	ELKS/RAB6-interacting/CAST family member 2	892	0.73
chr2_190044119_190044339	0.14	COL5A2	collagen, type V, alpha 2	376	0.9
chr18_32290517_32290846	0.14	DTNA	dystrobrevin, alpha	420	0.9
chr11_121968787_121969071	0.14	ENSG00000207971	.	1623	0.3
chr3_116755274_116755493	0.14	ENSG00000200372	.	71309	0.12
chr6_112192884_112193487	0.14	FYN	FYN oncogene related to SRC, FGR, YES	1055	0.66
chr16_50400842_50400993	0.14	RP11-21B23.1		1574	0.3
chr19_47679771_47679978	0.14	SAE1	SUMO1 activating enzyme subunit 1	45722	0.09
chr5_111090218_111090459	0.14	NREP	neuronal regeneration related protein	1610	0.42
chr6_82956530_82956750	0.14	IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	831	0.72
chr11_101918556_101918783	0.14	C11orf70	chromosome 11 open reading frame 70	480	0.77
chr12_86228304_86228474	0.14	RASSF9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	1959	0.44
chr11_12701419_12701570	0.14	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	4444	0.33
chr3_151989912_151990063	0.14	MBNL1-AS1	MBNL1 antisense RNA 1	2643	0.28
chr6_5752341_5752548	0.14	RP1-256G22.2		56939	0.16
chr10_96121693_96122003	0.14	NOC3L	nucleolar complex associated 3 homolog (S. cerevisiae)	137	0.96
chr3_125086964_125087115	0.14	ZNF148	zinc finger protein 148	7054	0.21
chr5_57751342_57751690	0.14	PLK2	polo-like kinase 2	4571	0.26
chr12_5368313_5368577	0.14	NTF3	neurotrophin 3	172834	0.03
chr12_107773843_107774162	0.14	ENSG00000200897	.	5478	0.28
chr11_122050333_122050506	0.14	ENSG00000207994	.	27403	0.16
chr2_14776009_14776160	0.14	AC011897.1	Uncharacterized protein	869	0.66
chr8_13371978_13372169	0.14	DLC1	deleted in liver cancer 1	201	0.95
chr21_35501672_35502212	0.13	SLC5A3	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	56072	0.12
chr1_99730395_99730700	0.13	LPPR4	Lipid phosphate phosphatase-related protein type 4	699	0.82
chr8_54817773_54817967	0.13	ENSG00000200528	.	9409	0.19
chr5_14147401_14147552	0.13	TRIO	trio Rho guanine nucleotide exchange factor	3647	0.38
chr1_115711115_115711431	0.13	TSPAN2	tetraspanin 2	79152	0.1
chr12_59310321_59310512	0.13	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3	2052	0.37
chr6_98298640_98298796	0.13	ENSG00000238367	.	173689	0.04
chr1_49344464_49344615	0.13	BEND5	BEN domain containing 5	101949	0.08
chr1_116918472_116918782	0.13	ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	2138	0.27
chr9_128463484_128463681	0.13	MAPKAP1	mitogen-activated protein kinase associated protein 1	5874	0.28
chr1_221509112_221509492	0.13	DUSP10	dual specificity phosphatase 10	401500	0.01
chr6_152701268_152701555	0.13	SYNE1-AS1	SYNE1 antisense RNA 1	270	0.91
chr21_34181326_34181477	0.13	C21orf62	chromosome 21 open reading frame 62	1373	0.37
chr2_216301006_216301560	0.13	AC012462.1		307	0.57
chr20_42647159_42647526	0.13	ENSG00000241229	.	11454	0.23
chr10_60859439_60859590	0.13	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like	76836	0.12
chr13_98532442_98532896	0.13	ENSG00000238407	.	5394	0.31
chr12_13328389_13328540	0.13	EMP1	epithelial membrane protein 1	21186	0.21
chr22_50680951_50681194	0.13	TUBGCP6	tubulin, gamma complex associated protein 6	1921	0.15
chr6_25276056_25276207	0.13	LRRC16A	leucine rich repeat containing 16A	3525	0.2
chr15_80364981_80365385	0.13	ZFAND6	zinc finger, AN1-type domain 6	251	0.94
chr10_17554144_17554295	0.13	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	57890	0.12
chr4_152148275_152148426	0.13	SH3D19	SH3 domain containing 19	600	0.77
chr1_164532740_164533333	0.13	PBX1	pre-B-cell leukemia homeobox 1	994	0.67
chr10_376062_376213	0.13	DIP2C	DIP2 disco-interacting protein 2 homolog C (Drosophila)	671	0.73
chrX_74966247_74966822	0.13	MAGEE2	melanoma antigen family E, 2	38545	0.23
chr7_129283433_129283584	0.13	NRF1	nuclear respiratory factor 1	13599	0.23
chr4_114897314_114897610	0.13	ARSJ	arylsulfatase family, member J	2690	0.37
chr2_189840264_189840425	0.13	COL3A1	collagen, type III, alpha 1	1245	0.47
chr17_15553766_15553944	0.13	RP11-640I15.1		1049	0.32
chr9_2838300_2838770	0.13	KIAA0020	KIAA0020	5706	0.3
chr2_192547837_192547988	0.13	NABP1	nucleic acid binding protein 1	4196	0.34
chr10_63808619_63808770	0.13	ARID5B	AT rich interactive domain 5B (MRF1-like)	276	0.95
chr11_86512357_86512728	0.13	PRSS23	protease, serine, 23	957	0.7
chr4_114216807_114216958	0.13	ANK2	ankyrin 2, neuronal	2744	0.39
chr1_33546320_33546691	0.13	ADC	arginine decarboxylase	209	0.94
chr21_17792302_17792515	0.13	ENSG00000207638	.	119001	0.06
chr6_127836184_127836541	0.13	SOGA3	SOGA family member 3	1397	0.51
chr2_66670252_66670507	0.13	MEIS1	Meis homeobox 1	282	0.85
chr7_94025506_94025990	0.12	COL1A2	collagen, type I, alpha 2	1875	0.46
chr9_18476160_18476529	0.12	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr10_4174092_4174250	0.12	KLF6	Kruppel-like factor 6	346698	0.01
chr15_73901500_73901651	0.12	NPTN	neuroplastin	23529	0.22
chr4_142250581_142250732	0.12	ENSG00000238695	.	31624	0.23
chr15_58600153_58600304	0.12	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	28766	0.22
chr11_23103600_23103751	0.12	CCDC179	coiled-coil domain containing 179	221703	0.02
chr8_103135084_103136044	0.12	NCALD	neurocalcin delta	614	0.72
chr6_157116874_157117032	0.12	RP11-230C9.3		15364	0.19
chr2_175710954_175711206	0.12	CHN1	chimerin 1	53	0.98
chr15_86162614_86163207	0.12	RP11-815J21.3		8010	0.15
chr2_205890097_205890340	0.12	PARD3B	par-3 family cell polarity regulator beta	479495	0.01
chr11_1061075_1061262	0.12	MUC2	mucin 2, oligomeric mucus/gel-forming	13707	0.16
chr13_50020768_50020928	0.12	AL136218.1	Sarcoma antigen NY-SAR-79; Uncharacterized protein	294	0.86
chr10_61997707_61998072	0.12	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	62351	0.15
chr5_54795571_54795722	0.12	ENSG00000265135	.	9108	0.22
chr2_74606600_74607395	0.12	DCTN1	dynactin 1	413	0.73
chr12_123599881_123600060	0.12	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	4928	0.21
chr8_135563902_135564089	0.12	ZFAT	zinc finger and AT hook domain containing	41570	0.18
chr3_57580599_57580768	0.12	ARF4	ADP-ribosylation factor 4	2369	0.17
chr21_17652021_17652264	0.12	ENSG00000201025	.	4947	0.35
chr8_103664786_103665058	0.12	KLF10	Kruppel-like factor 10	1681	0.44
chr17_13265618_13265967	0.12	ENSG00000266115	.	137853	0.05
chr17_32582682_32583141	0.12	AC005549.3	Uncharacterized protein	605	0.41
chr8_108518030_108518181	0.12	ANGPT1	angiopoietin 1	7822	0.33
chr3_52705556_52705775	0.12	PBRM1	polybromo 1	6918	0.09
chr11_114311191_114311379	0.12	REXO2	RNA exonuclease 2	442	0.82
chr9_133814218_133814626	0.12	FIBCD1	fibrinogen C domain containing 1	33	0.97
chr7_94035982_94036133	0.12	COL1A2	collagen, type I, alpha 2	12184	0.27
chr6_147850870_147851021	0.12	SAMD5	sterile alpha motif domain containing 5	20583	0.29
chr18_56528511_56528662	0.12	ZNF532	zinc finger protein 532	1246	0.46
chr17_12452739_12453131	0.12	MYOCD	myocardin	116371	0.06
chr16_65154468_65154619	0.12	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	1290	0.65
chr16_58162054_58162435	0.12	C16orf80	chromosome 16 open reading frame 80	1021	0.33
chr6_131382789_131382971	0.12	EPB41L2	erythrocyte membrane protein band 4.1-like 2	836	0.75
chr9_21964953_21966022	0.12	C9orf53	chromosome 9 open reading frame 53	1650	0.31
chr3_150131821_150132388	0.12	TSC22D2	TSC22 domain family, member 2	3308	0.35
chr2_213976639_213976790	0.12	IKZF2	IKAROS family zinc finger 2 (Helios)	36639	0.21
chr3_16551030_16551181	0.12	RFTN1	raftlin, lipid raft linker 1	3306	0.33
chr4_169752801_169753072	0.12	PALLD	palladin, cytoskeletal associated protein	220	0.9
chrY_14899611_14899762	0.12	USP9Y	ubiquitin specific peptidase 9, Y-linked	59284	0.16
chr7_100777700_100777901	0.12	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	7421	0.1
chr11_84844293_84844464	0.12	DLG2	discs, large homolog 2 (Drosophila)	211	0.97
chr3_89163237_89163857	0.12	EPHA3	EPH receptor A3	6721	0.35
chr17_67137803_67138011	0.12	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	108	0.97
chr21_17652326_17652785	0.12	ENSG00000201025	.	4534	0.36
chr2_227653875_227654026	0.12	IRS1	insulin receptor substrate 1	10525	0.21
chr4_178235041_178235192	0.12	NEIL3	nei endonuclease VIII-like 3 (E. coli)	4126	0.26
chr9_131316906_131317348	0.12	SPTAN1	spectrin, alpha, non-erythrocytic 1	2258	0.18
chr6_28922002_28922229	0.12	C6orf100	chromosome 6 open reading frame 100	10461	0.12
chr3_191048468_191048928	0.12	UTS2B	urotensin 2B	373	0.85
chr1_179111271_179111703	0.12	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	692	0.72

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.4	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.5	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.1	0.3	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.3	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.4	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.1	0.2	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.2	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.3	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.2	GO:0021825	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.2	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	0.2	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.4	GO:0060216	definitive hemopoiesis(GO:0060216)
0.1	0.3	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.1	0.1	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.1	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.2	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.2	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.2	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.3	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.2	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.3	GO:0071320	cellular response to cAMP(GO:0071320)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0070100	apoptotic process involved in luteolysis(GO:0061364) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.7	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0032278	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.2	GO:0002076	osteoblast development(GO:0002076)
0.0	0.0	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0090190	positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.1	GO:0060998	regulation of dendritic spine development(GO:0060998)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.1	GO:0010719	negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.5	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0002913	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.0	0.0	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.2	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.0	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.3	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0060601	lateral sprouting from an epithelium(GO:0060601)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0051971	positive regulation of transmission of nerve impulse(GO:0051971)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.2	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.3	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0043536	positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.0	GO:0042053	regulation of dopamine metabolic process(GO:0042053)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0090177	establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0	0.0	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.1	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.0	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.3	GO:0008038	neuron recognition(GO:0008038)
0.0	0.0	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0007512	adult heart development(GO:0007512)
0.0	0.1	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.0	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.0	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.0	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.1	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.1	GO:0031114	regulation of microtubule depolymerization(GO:0031114)
0.0	0.0	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.0	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0007628	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0	0.0	GO:0000470	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0007351	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.1	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0032823	natural killer cell differentiation(GO:0001779) regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.2	GO:0008589	regulation of smoothened signaling pathway(GO:0008589)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.0	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0021889	olfactory bulb interneuron differentiation(GO:0021889)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.3	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.3	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.0	GO:0044217	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.0	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.2	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.2	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	1.0	GO:0030016	myofibril(GO:0030016)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.6	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.5	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.4	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.3	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.5	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.2	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.2	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.3	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.2	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.3	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.0	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0043138	3'-5' DNA helicase activity(GO:0043138)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.0	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.0	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.2	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.0	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.0	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.9	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.6	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.7	NABA COLLAGENS	Genes encoding collagen proteins
0.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	PID ALK1 PATHWAY	ALK1 signaling events
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	0.1	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.1	0.1	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.2	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.3	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.2	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.2	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.4	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism