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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for HOXD11_HOXA11

Z-value: 0.56

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Transcription factors associated with HOXD11_HOXA11

Gene Symbol Gene ID Gene Info
HOXD11
ENSG00000128713.11 homeobox D11
HOXA11
ENSG00000005073.5 homeobox A11

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr2_176971216_176971605HOXD116040.475731-0.674.9e-02Click!
chr2_176971683_176972255HOXD11450.924613-0.511.6e-01Click!
chr2_176972526_176972677HOXD115870.3971930.176.5e-01Click!
chr2_176969688_176969839HOXD1122510.126484-0.088.4e-01Click!
chr2_176969448_176969655HOXD1124630.118195-0.049.2e-01Click!

Activity of the HOXD11_HOXA11 motif across conditions

Conditions sorted by the z-value of the HOXD11_HOXA11 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_120168336_120168615 0.31 FSTL1
 follistatin-like 1
 1363
 0.54
chr3_106063956_106064334 0.30 ENSG00000200610
 .
 170599
 0.04
chr4_119755136_119755442 0.28 SEC24D
 SEC24 family member D
 2004
 0.43
chr2_7152423_7152574 0.27 RNF144A
 ring finger protein 144A
 15427
 0.23
chr3_32010054_32010475 0.25 OSBPL10
 oxysterol binding protein-like 10
 12528
 0.2
chr7_14020163_14020323 0.25 ETV1
 ets variant 1
 5823
 0.29
chr12_11325045_11325196 0.24 RP11-785H5.2
1168
 0.4
chr3_29327656_29328192 0.24 RBMS3-AS3
 RBMS3 antisense RNA 3
 4293
 0.26
chr8_42063953_42065062 0.23 PLAT
 plasminogen activator, tissue
 576
 0.71
chr4_86700210_86700446 0.23 ARHGAP24
 Rho GTPase activating protein 24
 469
 0.88
chr6_128529501_128529738 0.23 PTPRK
 protein tyrosine phosphatase, receptor type, K
 113707
 0.07
chr6_53928552_53928746 0.23 MLIP-AS1
 MLIP antisense RNA 1
 15875
 0.2
chr7_134465735_134465936 0.22 CALD1
 caldesmon 1
 1406
 0.57
chr13_74636535_74636686 0.22 KLF12
 Kruppel-like factor 12
 67424
 0.15
chr7_116164164_116164509 0.21 CAV1
 caveolin 1, caveolae protein, 22kDa
 503
 0.76
chr2_151385576_151386025 0.21 RND3
 Rho family GTPase 3
 9725
 0.33
chr8_95816216_95816367 0.21 INTS8
 integrator complex subunit 8
 9248
 0.16
chr2_134432207_134432889 0.21 ENSG00000200708
 .
 78886
 0.11
chr10_112258642_112259418 0.21 DUSP5
 dual specificity phosphatase 5
 1434
 0.41
chr7_76958008_76958159 0.21 GSAP
 gamma-secretase activating protein
 1601
 0.47
chr3_183893852_183894003 0.21 AP2M1
 adaptor-related protein complex 2, mu 1 subunit
 639
 0.55
chr8_23711697_23711872 0.20 STC1
 stanniocalcin 1
 40
 0.98
chr5_54456456_54456818 0.20 GPX8
 glutathione peroxidase 8 (putative)
 639
 0.58
chr8_8745358_8745509 0.19 MFHAS1
 malignant fibrous histiocytoma amplified sequence 1
 5722
 0.22
chr7_18549207_18549425 0.19 HDAC9
 histone deacetylase 9
 380
 0.92
chr4_41178199_41178352 0.19 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 38200
 0.15
chr17_15281303_15281454 0.19 ENSG00000239888
 .
 30323
 0.15
chr5_110846365_110846666 0.18 STARD4-AS1
 STARD4 antisense RNA 1
 1409
 0.37
chr5_54456050_54456451 0.18 GPX8
 glutathione peroxidase 8 (putative)
 252
 0.86
chr1_218521749_218522027 0.18 TGFB2
 transforming growth factor, beta 2
 2311
 0.31
chr16_83377985_83378136 0.18 RP11-543N12.1
53532
 0.15
chr5_50040977_50041222 0.18 PARP8
 poly (ADP-ribose) polymerase family, member 8
 77708
 0.12
chr2_160291322_160291473 0.18 BAZ2B
 bromodomain adjacent to zinc finger domain, 2B
 1936
 0.41
chr7_134464463_134465343 0.18 CALD1
 caldesmon 1
 474
 0.89
chr5_155754820_155754971 0.18 SGCD
 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
 1128
 0.68
chr14_51242372_51242693 0.18 NIN
 ninein (GSK3B interacting protein)
 9019
 0.17
chr7_94029074_94029225 0.17 COL1A2
 collagen, type I, alpha 2
 5276
 0.3
chr8_49292577_49292728 0.17 ENSG00000252710
 .
 72062
 0.13
chr5_35130063_35130359 0.17 PRLR
 prolactin receptor
 235
 0.95
chr15_71054590_71054766 0.17 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 1091
 0.55
chr8_16612533_16612758 0.17 ENSG00000264092
 .
 108360
 0.07
chr4_138452878_138453572 0.17 PCDH18
 protocadherin 18
 340
 0.94
chrX_43832059_43832293 0.17 NDP
 Norrie disease (pseudoglioma)
 574
 0.81
chr15_61520624_61520983 0.16 RORA
 RAR-related orphan receptor A
 715
 0.73
chr15_25915762_25916070 0.16 ATP10A
 ATPase, class V, type 10A
 24056
 0.19
chr10_133793669_133793880 0.16 BNIP3
 BCL2/adenovirus E1B 19kDa interacting protein 3
 1653
 0.46
chr13_36047635_36048256 0.16 MAB21L1
 mab-21-like 1 (C. elegans)
 2887
 0.26
chr3_112358713_112358917 0.16 CCDC80
 coiled-coil domain containing 80
 1301
 0.54
chr8_58715313_58715521 0.16 FAM110B
 family with sequence similarity 110, member B
 191696
 0.03
chr1_92329705_92329906 0.16 TGFBR3
 transforming growth factor, beta receptor III
 2655
 0.31
chr3_49538097_49538499 0.16 DAG1
 dystroglycan 1 (dystrophin-associated glycoprotein 1)
 30546
 0.11
chr17_40561693_40562104 0.16 ENSG00000221020
 .
 10871
 0.11
chr20_50550896_50551117 0.16 ENSG00000263659
 .
 6366
 0.22
chr7_10491618_10491769 0.16 ENSG00000212422
 .
 229269
 0.02
chr7_121514140_121514423 0.16 PTPRZ1
 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
 866
 0.74
chr1_178310607_178310919 0.16 RASAL2
 RAS protein activator like 2
 157
 0.97
chr13_50649761_50650212 0.16 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 6321
 0.18
chr2_207873339_207873490 0.16 CPO
 carboxypeptidase O
 69136
 0.11
chr16_80181289_80181449 0.15 DYNLRB2
 dynein, light chain, roadblock-type 2
 393262
 0.01
chr17_46654170_46654895 0.15 HOXB3
 homeobox B3
 2094
 0.12
chr10_17275327_17275794 0.15 RP11-124N14.3
1272
 0.37
chr1_88150758_88150976 0.15 ENSG00000199318
 .
 231811
 0.02
chr9_20570670_20570821 0.15 ENSG00000252324
 .
 5471
 0.24
chr7_82072002_82072462 0.15 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 799
 0.78
chr4_38870502_38870773 0.15 ENSG00000207944
 .
 984
 0.38
chr10_17151338_17151489 0.15 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 18423
 0.23
chr11_31826043_31826338 0.15 PAX6
 paired box 6
 2279
 0.32
chr6_122791067_122791230 0.15 SERINC1
 serine incorporator 1
 1819
 0.33
chr8_22342638_22342826 0.15 PPP3CC
 protein phosphatase 3, catalytic subunit, gamma isozyme
 9627
 0.15
chr13_98859156_98859307 0.15 ENSG00000263399
 .
 1547
 0.31
chr22_29107845_29108091 0.15 CHEK2
 checkpoint kinase 2
 25
 0.97
chr4_38754112_38754445 0.15 ENSG00000222230
 .
 6235
 0.19
chr17_45352801_45353270 0.15 ENSG00000238419
 .
 16249
 0.13
chr1_57042188_57042339 0.15 PPAP2B
 phosphatidic acid phosphatase type 2B
 2978
 0.37
chr13_47470589_47471243 0.15 HTR2A
 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
 253
 0.95
chr1_240262074_240262225 0.15 FMN2
 formin 2
 6969
 0.27
chr8_128751469_128751888 0.15 MYC
 v-myc avian myelocytomatosis viral oncogene homolog
 3201
 0.34
chr16_4069505_4069681 0.15 RP11-462G12.4
12420
 0.19
chr10_33239282_33239433 0.15 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 5234
 0.31
chr11_132813237_132813595 0.15 OPCML
 opioid binding protein/cell adhesion molecule-like
 150
 0.98
chr6_45523951_45524153 0.14 ENSG00000252738
 .
 89789
 0.09
chr4_53411844_53412014 0.14 ENSG00000239068
 .
 35750
 0.18
chr17_57860675_57860960 0.14 RP11-619I22.1
1357
 0.39
chr8_108441987_108442138 0.14 ANGPT1
 angiopoietin 1
 65161
 0.15
chr6_26743586_26743955 0.14 ZNF322
 zinc finger protein 322
 83790
 0.08
chr3_175389807_175390608 0.14 ENSG00000201648
 .
 62940
 0.12
chr3_56501298_56501701 0.14 ERC2
 ELKS/RAB6-interacting/CAST family member 2
 892
 0.73
chr2_190044119_190044339 0.14 COL5A2
 collagen, type V, alpha 2
 376
 0.9
chr18_32290517_32290846 0.14 DTNA
 dystrobrevin, alpha
 420
 0.9
chr11_121968787_121969071 0.14 ENSG00000207971
 .
 1623
 0.3
chr3_116755274_116755493 0.14 ENSG00000200372
 .
 71309
 0.12
chr6_112192884_112193487 0.14 FYN
 FYN oncogene related to SRC, FGR, YES
 1055
 0.66
chr16_50400842_50400993 0.14 RP11-21B23.1
1574
 0.3
chr19_47679771_47679978 0.14 SAE1
 SUMO1 activating enzyme subunit 1
 45722
 0.09
chr5_111090218_111090459 0.14 NREP
 neuronal regeneration related protein
 1610
 0.42
chr6_82956530_82956750 0.14 IBTK
 inhibitor of Bruton agammaglobulinemia tyrosine kinase
 831
 0.72
chr11_101918556_101918783 0.14 C11orf70
 chromosome 11 open reading frame 70
 480
 0.77
chr12_86228304_86228474 0.14 RASSF9
 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
 1959
 0.44
chr11_12701419_12701570 0.14 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 4444
 0.33
chr3_151989912_151990063 0.14 MBNL1-AS1
 MBNL1 antisense RNA 1
 2643
 0.28
chr6_5752341_5752548 0.14 RP1-256G22.2
56939
 0.16
chr10_96121693_96122003 0.14 NOC3L
 nucleolar complex associated 3 homolog (S. cerevisiae)
 137
 0.96
chr3_125086964_125087115 0.14 ZNF148
 zinc finger protein 148
 7054
 0.21
chr5_57751342_57751690 0.14 PLK2
 polo-like kinase 2
 4571
 0.26
chr12_5368313_5368577 0.14 NTF3
 neurotrophin 3
 172834
 0.03
chr12_107773843_107774162 0.14 ENSG00000200897
 .
 5478
 0.28
chr11_122050333_122050506 0.14 ENSG00000207994
 .
 27403
 0.16
chr2_14776009_14776160 0.14 AC011897.1
 Uncharacterized protein
 869
 0.66
chr8_13371978_13372169 0.14 DLC1
 deleted in liver cancer 1
 201
 0.95
chr21_35501672_35502212 0.13 SLC5A3
 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
 56072
 0.12
chr1_99730395_99730700 0.13 LPPR4
 Lipid phosphate phosphatase-related protein type 4
 699
 0.82
chr8_54817773_54817967 0.13 ENSG00000200528
 .
 9409
 0.19
chr5_14147401_14147552 0.13 TRIO
 trio Rho guanine nucleotide exchange factor
 3647
 0.38
chr1_115711115_115711431 0.13 TSPAN2
 tetraspanin 2
 79152
 0.1
chr12_59310321_59310512 0.13 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 2052
 0.37
chr6_98298640_98298796 0.13 ENSG00000238367
 .
 173689
 0.04
chr1_49344464_49344615 0.13 BEND5
 BEN domain containing 5
 101949
 0.08
chr1_116918472_116918782 0.13 ATP1A1
 ATPase, Na+/K+ transporting, alpha 1 polypeptide
 2138
 0.27
chr9_128463484_128463681 0.13 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 5874
 0.28
chr1_221509112_221509492 0.13 DUSP10
 dual specificity phosphatase 10
 401500
 0.01
chr6_152701268_152701555 0.13 SYNE1-AS1
 SYNE1 antisense RNA 1
 270
 0.91
chr21_34181326_34181477 0.13 C21orf62
 chromosome 21 open reading frame 62
 1373
 0.37
chr2_216301006_216301560 0.13 AC012462.1
307
 0.57
chr20_42647159_42647526 0.13 ENSG00000241229
 .
 11454
 0.23
chr10_60859439_60859590 0.13 PHYHIPL
 phytanoyl-CoA 2-hydroxylase interacting protein-like
 76836
 0.12
chr13_98532442_98532896 0.13 ENSG00000238407
 .
 5394
 0.31
chr12_13328389_13328540 0.13 EMP1
 epithelial membrane protein 1
 21186
 0.21
chr22_50680951_50681194 0.13 TUBGCP6
 tubulin, gamma complex associated protein 6
 1921
 0.15
chr6_25276056_25276207 0.13 LRRC16A
 leucine rich repeat containing 16A
 3525
 0.2
chr15_80364981_80365385 0.13 ZFAND6
 zinc finger, AN1-type domain 6
 251
 0.94
chr10_17554144_17554295 0.13 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 57890
 0.12
chr4_152148275_152148426 0.13 SH3D19
 SH3 domain containing 19
 600
 0.77
chr1_164532740_164533333 0.13 PBX1
 pre-B-cell leukemia homeobox 1
 994
 0.67
chr10_376062_376213 0.13 DIP2C
 DIP2 disco-interacting protein 2 homolog C (Drosophila)
 671
 0.73
chrX_74966247_74966822 0.13 MAGEE2
 melanoma antigen family E, 2
 38545
 0.23
chr7_129283433_129283584 0.13 NRF1
 nuclear respiratory factor 1
 13599
 0.23
chr4_114897314_114897610 0.13 ARSJ
 arylsulfatase family, member J
 2690
 0.37
chr2_189840264_189840425 0.13 COL3A1
 collagen, type III, alpha 1
 1245
 0.47
chr17_15553766_15553944 0.13 RP11-640I15.1
1049
 0.32
chr9_2838300_2838770 0.13 KIAA0020
 KIAA0020
 5706
 0.3
chr2_192547837_192547988 0.13 NABP1
 nucleic acid binding protein 1
 4196
 0.34
chr10_63808619_63808770 0.13 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 276
 0.95
chr11_86512357_86512728 0.13 PRSS23
 protease, serine, 23
 957
 0.7
chr4_114216807_114216958 0.13 ANK2
 ankyrin 2, neuronal
 2744
 0.39
chr1_33546320_33546691 0.13 ADC
 arginine decarboxylase
 209
 0.94
chr21_17792302_17792515 0.13 ENSG00000207638
 .
 119001
 0.06
chr6_127836184_127836541 0.13 SOGA3
 SOGA family member 3
 1397
 0.51
chr2_66670252_66670507 0.13 MEIS1
 Meis homeobox 1
 282
 0.85
chr7_94025506_94025990 0.12 COL1A2
 collagen, type I, alpha 2
 1875
 0.46
chr9_18476160_18476529 0.12 ADAMTSL1
 ADAMTS-like 1
 2113
 0.45
chr10_4174092_4174250 0.12 KLF6
 Kruppel-like factor 6
 346698
 0.01
chr15_73901500_73901651 0.12 NPTN
 neuroplastin
 23529
 0.22
chr4_142250581_142250732 0.12 ENSG00000238695
 .
 31624
 0.23
chr15_58600153_58600304 0.12 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
 28766
 0.22
chr11_23103600_23103751 0.12 CCDC179
 coiled-coil domain containing 179
 221703
 0.02
chr8_103135084_103136044 0.12 NCALD
 neurocalcin delta
 614
 0.72
chr6_157116874_157117032 0.12 RP11-230C9.3
15364
 0.19
chr2_175710954_175711206 0.12 CHN1
 chimerin 1
 53
 0.98
chr15_86162614_86163207 0.12 RP11-815J21.3
8010
 0.15
chr2_205890097_205890340 0.12 PARD3B
 par-3 family cell polarity regulator beta
 479495
 0.01
chr11_1061075_1061262 0.12 MUC2
 mucin 2, oligomeric mucus/gel-forming
 13707
 0.16
chr13_50020768_50020928 0.12 AL136218.1
 Sarcoma antigen NY-SAR-79; Uncharacterized protein
 294
 0.86
chr10_61997707_61998072 0.12 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 62351
 0.15
chr5_54795571_54795722 0.12 ENSG00000265135
 .
 9108
 0.22
chr2_74606600_74607395 0.12 DCTN1
 dynactin 1
 413
 0.73
chr12_123599881_123600060 0.12 PITPNM2
 phosphatidylinositol transfer protein, membrane-associated 2
 4928
 0.21
chr8_135563902_135564089 0.12 ZFAT
 zinc finger and AT hook domain containing
 41570
 0.18
chr3_57580599_57580768 0.12 ARF4
 ADP-ribosylation factor 4
 2369
 0.17
chr21_17652021_17652264 0.12 ENSG00000201025
 .
 4947
 0.35
chr8_103664786_103665058 0.12 KLF10
 Kruppel-like factor 10
 1681
 0.44
chr17_13265618_13265967 0.12 ENSG00000266115
 .
 137853
 0.05
chr17_32582682_32583141 0.12 AC005549.3
 Uncharacterized protein
 605
 0.41
chr8_108518030_108518181 0.12 ANGPT1
 angiopoietin 1
 7822
 0.33
chr3_52705556_52705775 0.12 PBRM1
 polybromo 1
 6918
 0.09
chr11_114311191_114311379 0.12 REXO2
 RNA exonuclease 2
 442
 0.82
chr9_133814218_133814626 0.12 FIBCD1
 fibrinogen C domain containing 1
 33
 0.97
chr7_94035982_94036133 0.12 COL1A2
 collagen, type I, alpha 2
 12184
 0.27
chr6_147850870_147851021 0.12 SAMD5
 sterile alpha motif domain containing 5
 20583
 0.29
chr18_56528511_56528662 0.12 ZNF532
 zinc finger protein 532
 1246
 0.46
chr17_12452739_12453131 0.12 MYOCD
 myocardin
 116371
 0.06
chr16_65154468_65154619 0.12 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 1290
 0.65
chr16_58162054_58162435 0.12 C16orf80
 chromosome 16 open reading frame 80
 1021
 0.33
chr6_131382789_131382971 0.12 EPB41L2
 erythrocyte membrane protein band 4.1-like 2
 836
 0.75
chr9_21964953_21966022 0.12 C9orf53
 chromosome 9 open reading frame 53
 1650
 0.31
chr3_150131821_150132388 0.12 TSC22D2
 TSC22 domain family, member 2
 3308
 0.35
chr2_213976639_213976790 0.12 IKZF2
 IKAROS family zinc finger 2 (Helios)
 36639
 0.21
chr3_16551030_16551181 0.12 RFTN1
 raftlin, lipid raft linker 1
 3306
 0.33
chr4_169752801_169753072 0.12 PALLD
 palladin, cytoskeletal associated protein
 220
 0.9
chrY_14899611_14899762 0.12 USP9Y
 ubiquitin specific peptidase 9, Y-linked
 59284
 0.16
chr7_100777700_100777901 0.12 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 7421
 0.1
chr11_84844293_84844464 0.12 DLG2
 discs, large homolog 2 (Drosophila)
 211
 0.97
chr3_89163237_89163857 0.12 EPHA3
 EPH receptor A3
 6721
 0.35
chr17_67137803_67138011 0.12 ABCA6
 ATP-binding cassette, sub-family A (ABC1), member 6
 108
 0.97
chr21_17652326_17652785 0.12 ENSG00000201025
 .
 4534
 0.36
chr2_227653875_227654026 0.12 IRS1
 insulin receptor substrate 1
 10525
 0.21
chr4_178235041_178235192 0.12 NEIL3
 nei endonuclease VIII-like 3 (E. coli)
 4126
 0.26
chr9_131316906_131317348 0.12 SPTAN1
 spectrin, alpha, non-erythrocytic 1
 2258
 0.18
chr6_28922002_28922229 0.12 C6orf100
 chromosome 6 open reading frame 100
 10461
 0.12
chr3_191048468_191048928 0.12 UTS2B
 urotensin 2B
 373
 0.85
chr1_179111271_179111703 0.12 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
 692
 0.72

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.4 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.1 0.3 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.3 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.3 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.3 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0021825 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1 0.2 GO:0010761 fibroblast migration(GO:0010761)
0.1 0.2 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.3 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.1 0.1 GO:1901722 regulation of cell proliferation involved in kidney development(GO:1901722)
0.0 0.1 GO:0051832 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.0 0.2 GO:0043267 negative regulation of potassium ion transport(GO:0043267)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.2 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.1 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.2 GO:0042977 activation of JAK2 kinase activity(GO:0042977)
0.0 0.3 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.0 GO:0070100 apoptotic process involved in luteolysis(GO:0061364) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0010159 specification of organ position(GO:0010159)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0032278 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.1 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.2 GO:0002076 osteoblast development(GO:0002076)
0.0 0.0 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0090190 positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.1 GO:0060998 regulation of dendritic spine development(GO:0060998)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0002913 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.0 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.2 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 0.0 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.0 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.3 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.0 GO:0060601 lateral sprouting from an epithelium(GO:0060601)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0060363 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.0 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.0 0.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0 0.2 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.0 GO:0031223 auditory behavior(GO:0031223)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.3 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.0 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.0 GO:0042053 regulation of dopamine metabolic process(GO:0042053)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0 0.0 GO:0014742 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.1 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.0 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.3 GO:0008038 neuron recognition(GO:0008038)
0.0 0.0 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0007512 adult heart development(GO:0007512)
0.0 0.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0007144 female meiosis I(GO:0007144)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.0 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.0 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.0 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.0 GO:0007494 midgut development(GO:0007494)
0.0 0.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.1 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.0 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.0 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0007628 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.0 GO:0000470 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0090114 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.2 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.0 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.2 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 0.1 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0032823 natural killer cell differentiation(GO:0001779) regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.0 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.0 GO:0015825 L-serine transport(GO:0015825)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.0 0.0 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0048840 otolith development(GO:0048840)
0.0 0.0 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.0 GO:0021889 olfactory bulb interneuron differentiation(GO:0021889)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.0 GO:0044217 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 1.0 GO:0030016 myofibril(GO:0030016)
0.0 0.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.0 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.2 GO:0051378 serotonin binding(GO:0051378)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.0 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.0 GO:0035198 miRNA binding(GO:0035198)
0.0 0.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.0 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.0 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.0 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.6 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.0 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.1 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism