Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

Results for HSF1

Z-value: 1.30

Motif logo

Transcription factors associated with HSF1

Gene Symbol	Gene ID	Gene Info
HSF1 Ensembl NCBI GeneCards UniProt	ENSG00000185122.6	heat shock transcription factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr8_145515646_145516282	HSF1	298	0.709792	-0.41	2.7e-01	Click!
chr8_145515345_145515644	HSF1	214	0.658411	-0.22	5.7e-01	Click!

Activity of the HSF1 motif across conditions

Conditions sorted by the z-value of the HSF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_29675034_29675898	1.78	QPRT	quinolinate phosphoribosyltransferase	866	0.35
chr14_22961374_22961769	0.66	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	5400	0.11
chr3_183273082_183273407	0.59	KLHL6	kelch-like family member 6	233	0.92
chr14_100532787_100533367	0.59	EVL	Enah/Vasp-like	303	0.88
chr10_8098395_8099007	0.58	GATA3	GATA binding protein 3	1932	0.5
chr19_54875923_54876565	0.57	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	170	0.91
chr12_47611900_47612286	0.54	PCED1B	PC-esterase domain containing 1B	1712	0.41
chr13_30528667_30528971	0.53	LINC00572	long intergenic non-protein coding RNA 572	28031	0.25
chr11_60739463_60739620	0.53	CD6	CD6 molecule	203	0.89
chr2_202125315_202125762	0.52	CASP8	caspase 8, apoptosis-related cysteine peptidase	315	0.9
chr1_167486584_167486784	0.50	CD247	CD247 molecule	1091	0.54
chr11_60870810_60871026	0.50	CD5	CD5 molecule	937	0.56
chr12_109026699_109026850	0.49	SELPLG	selectin P ligand	896	0.46
chr15_80262648_80263745	0.49	BCL2A1	BCL2-related protein A1	315	0.89
chr17_75451832_75452118	0.47	SEPT9	septin 9	473	0.77
chr3_16327973_16328244	0.47	OXNAD1	oxidoreductase NAD-binding domain containing 1	17360	0.16
chr3_108542080_108542294	0.47	TRAT1	T cell receptor associated transmembrane adaptor 1	568	0.83
chr14_22982783_22983297	0.46	TRAJ15	T cell receptor alpha joining 15	15540	0.1
chr7_150150318_150150563	0.46	GIMAP8	GTPase, IMAP family member 8	2722	0.24
chr19_50003533_50003936	0.44	hsa-mir-150	hsa-mir-150	47	0.8
chr6_112079133_112079284	0.44	FYN	FYN oncogene related to SRC, FGR, YES	1109	0.63
chrX_15176719_15176870	0.44	ASB9	ankyrin repeat and SOCS box containing 9	96093	0.08
chrX_30594869_30596024	0.44	CXorf21	chromosome X open reading frame 21	515	0.84
chr17_45812399_45812645	0.44	TBX21	T-box 21	1912	0.27
chr3_150920478_150920863	0.43	GPR171	G protein-coupled receptor 171	309	0.87
chr8_66749078_66749602	0.42	PDE7A	phosphodiesterase 7A	1643	0.51
chrY_15590049_15590474	0.42	UTY	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	1284	0.62
chr12_49311955_49312141	0.42	FKBP11	FK506 binding protein 11, 19 kDa	6702	0.08
chrY_7158530_7158855	0.42	PRKY	protein kinase, Y-linked, pseudogene	16338	0.2
chr17_75450125_75450790	0.41	SEPT9	septin 9	295	0.88
chr7_150414678_150414897	0.41	GIMAP1	GTPase, IMAP family member 1	1142	0.45
chr14_22977019_22977170	0.41	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	20923	0.09
chr4_40202041_40202542	0.40	RHOH	ras homolog family member H	327	0.9
chr15_59344480_59344631	0.40	RNF111	ring finger protein 111	20732	0.16
chr10_3710614_3710914	0.39	RP11-184A2.3		82495	0.1
chr1_169677778_169678021	0.38	SELL	selectin L	2940	0.26
chr11_71709974_71710217	0.38	IL18BP	interleukin 18 binding protein	14	0.96
chr2_240219542_240220118	0.38	ENSG00000265215	.	7327	0.19
chrX_129219562_129219812	0.37	ELF4	E74-like factor 4 (ets domain transcription factor)	24649	0.18
chr1_156785806_156786457	0.37	SH2D2A	SH2 domain containing 2A	495	0.51
chr14_22985583_22985743	0.37	TRAJ15	T cell receptor alpha joining 15	12917	0.1
chr19_11159843_11160026	0.37	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	9577	0.14
chr1_6524907_6525205	0.37	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	634	0.58
chr11_118175569_118175788	0.36	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	64	0.96
chr3_114014633_114014828	0.36	TIGIT	T cell immunoreceptor with Ig and ITIM domains	896	0.58
chrY_21906956_21907224	0.36	KDM5D	lysine (K)-specific demethylase 5D	265	0.96
chr7_3083968_3084119	0.35	CARD11	caspase recruitment domain family, member 11	464	0.86
chr6_31323146_31323355	0.35	HLA-B	major histocompatibility complex, class I, B	1714	0.23
chr20_57722405_57722705	0.35	ZNF831	zinc finger protein 831	43520	0.15
chr14_22920033_22920259	0.35	TRDD3	T cell receptor delta diversity 3	2041	0.19
chr14_22977741_22978031	0.34	TRAJ15	T cell receptor alpha joining 15	20694	0.09
chrX_129220691_129220952	0.34	ELF4	E74-like factor 4 (ets domain transcription factor)	23515	0.18
chr6_149805475_149805626	0.34	ZC3H12D	zinc finger CCCH-type containing 12D	576	0.72
chr1_100887352_100887656	0.34	ENSG00000216067	.	43173	0.14
chr5_148188537_148188779	0.34	ADRB2	adrenoceptor beta 2, surface	17498	0.25
chr6_30459024_30459175	0.34	HLA-E	major histocompatibility complex, class I, E	1855	0.27
chr1_111743031_111743253	0.33	DENND2D	DENN/MADD domain containing 2D	169	0.6
chr2_204572133_204572358	0.33	CD28	CD28 molecule	829	0.71
chr5_176785343_176785607	0.33	RGS14	regulator of G-protein signaling 14	637	0.54
chr7_99950179_99950442	0.33	PVRIG2P	poliovirus receptor related immunoglobulin domain containing 2, pseudogene	327	0.45
chr6_149152259_149152413	0.32	UST	uronyl-2-sulfotransferase	83872	0.1
chr19_3180678_3181240	0.32	S1PR4	sphingosine-1-phosphate receptor 4	2223	0.2
chr13_99966619_99966770	0.32	GPR183	G protein-coupled receptor 183	7035	0.21
chrX_128917010_128917187	0.32	SASH3	SAM and SH3 domain containing 3	3138	0.26
chr10_11212951_11213685	0.32	RP3-323N1.2		21	0.98
chr11_104904746_104905919	0.32	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chr1_160681036_160681588	0.32	CD48	CD48 molecule	281	0.89
chr14_22992025_22992229	0.31	TRAJ15	T cell receptor alpha joining 15	6453	0.11
chr1_167487512_167487717	0.31	CD247	CD247 molecule	161	0.96
chr9_132175289_132175508	0.31	ENSG00000242281	.	42658	0.14
chr20_3780325_3780476	0.31	CDC25B	cell division cycle 25B	3322	0.15
chr5_32532091_32532542	0.31	SUB1	SUB1 homolog (S. cerevisiae)	392	0.9
chrX_12990257_12990408	0.31	TMSB4X	thymosin beta 4, X-linked	2895	0.31
chr17_29637369_29637894	0.31	EVI2B	ecotropic viral integration site 2B	3471	0.16
chr16_84628728_84628899	0.31	RP11-61F12.1		814	0.61
chr9_78508950_78509101	0.31	PCSK5	proprotein convertase subtilisin/kexin type 5	3404	0.31
chrX_153360358_153360509	0.30	MECP2	methyl CpG binding protein 2 (Rett syndrome)	2003	0.26
chrY_15815919_15816489	0.30	TMSB4Y	thymosin beta 4, Y-linked	757	0.72
chr1_32739822_32739973	0.30	LCK	lymphocyte-specific protein tyrosine kinase	34	0.95
chr6_128221812_128222507	0.30	THEMIS	thymocyte selection associated	56	0.99
chr10_135088206_135088485	0.30	ADAM8	ADAM metallopeptidase domain 8	2009	0.18
chr9_134139798_134140094	0.30	FAM78A	family with sequence similarity 78, member A	5934	0.19
chr2_235397304_235397485	0.29	ARL4C	ADP-ribosylation factor-like 4C	7850	0.33
chr14_22958789_22958996	0.29	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	2721	0.15
chr12_92532493_92532715	0.29	C12orf79	chromosome 12 open reading frame 79	1807	0.32
chr8_128988204_128988427	0.29	ENSG00000221771	.	15436	0.16
chr19_4915707_4915936	0.29	ARRDC5	arrestin domain containing 5	12942	0.12
chr22_20783387_20783561	0.29	SCARF2	scavenger receptor class F, member 2	8638	0.11
chr19_16438433_16439148	0.29	KLF2	Kruppel-like factor 2	3139	0.19
chr12_122228062_122228376	0.29	RHOF	ras homolog family member F (in filopodia)	3047	0.21
chr21_45564674_45564825	0.29	C21orf33	chromosome 21 open reading frame 33	8748	0.15
chr20_42697459_42697755	0.29	TOX2	TOX high mobility group box family member 2	14616	0.22
chr12_92531544_92532018	0.29	C12orf79	chromosome 12 open reading frame 79	984	0.53
chr16_50776896_50777610	0.29	RP11-327F22.1		527	0.39
chr16_81527642_81527793	0.29	CMIP	c-Maf inducing protein	1237	0.6
chr1_209931769_209931920	0.29	TRAF3IP3	TRAF3 interacting protein 3	1	0.97
chr7_50350295_50350528	0.28	IKZF1	IKAROS family zinc finger 1 (Ikaros)	2093	0.45
chr22_47882647_47882798	0.28	LL22NC03-75H12.2	Novel protein; Uncharacterized protein	138	0.98
chr20_62184252_62184657	0.28	C20orf195	chromosome 20 open reading frame 195	81	0.94
chr7_44662846_44662997	0.28	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	1140	0.49
chr4_37894512_37894663	0.28	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1867	0.44
chr18_28828923_28829074	0.28	DSG1	desmoglein 1	69054	0.09
chr5_156696070_156696221	0.28	CYFIP2	cytoplasmic FMR1 interacting protein 2	217	0.91
chr4_329625_329776	0.28	ZNF141	zinc finger protein 141	1909	0.3
chr1_28199781_28200360	0.28	THEMIS2	thymocyte selection associated family member 2	991	0.4
chr20_55004696_55004919	0.28	CASS4	Cas scaffolding protein family member 4	17490	0.12
chr7_43687925_43688483	0.28	COA1	cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)	1691	0.42
chr19_49014061_49014374	0.28	LMTK3	lemur tyrosine kinase 3	844	0.46
chr1_9486266_9486417	0.28	ENSG00000252956	.	11496	0.23
chr14_99658183_99658959	0.27	AL162151.4		33818	0.19
chr21_32555669_32555820	0.27	TIAM1	T-cell lymphoma invasion and metastasis 1	53205	0.16
chr6_30459986_30460189	0.27	HLA-E	major histocompatibility complex, class I, E	2843	0.2
chr5_52021818_52021969	0.27	ITGA1	integrin, alpha 1	61837	0.12
chr9_134150778_134151758	0.27	FAM78A	family with sequence similarity 78, member A	666	0.69
chr17_56414167_56414399	0.27	BZRAP1-AS1	BZRAP1 antisense RNA 1	281	0.76
chr22_37881004_37881696	0.27	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	683	0.62
chr2_219725007_219725158	0.27	WNT6	wingless-type MMTV integration site family, member 6	538	0.68
chr16_84582211_84582362	0.27	TLDC1	TBC/LysM-associated domain containing 1	5353	0.2
chr9_130728110_130728328	0.27	FAM102A	family with sequence similarity 102, member A	14573	0.1
chrX_153360812_153361094	0.27	MECP2	methyl CpG binding protein 2 (Rett syndrome)	1483	0.33
chr16_30196259_30196584	0.27	RP11-455F5.5		143	0.71
chr13_110381649_110381907	0.27	LINC00676	long intergenic non-protein coding RNA 676	1149	0.63
chr11_67174361_67174809	0.27	TBC1D10C	TBC1 domain family, member 10C	2925	0.09
chr2_175460517_175460758	0.27	WIPF1	WAS/WASL interacting protein family, member 1	1856	0.33
chr19_49839028_49839359	0.26	CD37	CD37 molecule	472	0.63
chr19_55014108_55014308	0.26	LAIR2	leukocyte-associated immunoglobulin-like receptor 2	85	0.94
chr21_45579010_45579199	0.26	AP001055.1		14476	0.13
chr4_100749650_100749801	0.26	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	11722	0.23
chr17_33864237_33864745	0.26	SLFN12L	schlafen family member 12-like	389	0.76
chrX_15767915_15768266	0.26	CA5B	carbonic anhydrase VB, mitochondrial	3	0.98
chr1_111418266_111418463	0.26	CD53	CD53 molecule	2588	0.29
chrX_41777222_41777373	0.26	ENSG00000251807	.	1305	0.5
chr14_99726303_99726510	0.26	AL109767.1		2879	0.29
chr5_39208188_39208339	0.26	FYB	FYN binding protein	5134	0.31
chr18_60867563_60867714	0.26	ENSG00000238988	.	5740	0.25
chr15_75077635_75077786	0.26	CSK	c-src tyrosine kinase	2764	0.16
chr19_17515989_17516450	0.26	BST2	bone marrow stromal cell antigen 2	238	0.54
chr16_28996851_28997002	0.26	LAT	linker for activation of T cells	187	0.87
chr2_74214074_74214388	0.26	DGUOK-AS1	DGUOK antisense RNA 1	5663	0.17
chr6_167507024_167507239	0.26	CCR6	chemokine (C-C motif) receptor 6	18164	0.18
chr11_134145576_134146222	0.25	GLB1L3	galactosidase, beta 1-like 3	736	0.61
chrX_117662421_117662652	0.25	DOCK11	dedicator of cytokinesis 11	32664	0.18
chr15_79236726_79237037	0.25	CTSH	cathepsin H	552	0.76
chr15_61132614_61132765	0.25	RP11-554D20.1		75750	0.11
chr10_135049457_135049800	0.25	VENTX	VENT homeobox	1280	0.31
chr2_98334070_98334346	0.25	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	4185	0.2
chr14_23012220_23012495	0.25	AE000662.92	Uncharacterized protein	13177	0.1
chr12_120548705_120548856	0.25	RAB35	RAB35, member RAS oncogene family	5760	0.16
chr20_62271176_62271486	0.25	CTD-3184A7.4		12728	0.09
chr8_143534587_143534874	0.25	BAI1	brain-specific angiogenesis inhibitor 1	3939	0.25
chrX_55515224_55516379	0.25	USP51	ubiquitin specific peptidase 51	166	0.96
chr19_1354407_1354797	0.25	MUM1	melanoma associated antigen (mutated) 1	108	0.93
chr22_20905991_20906349	0.25	MED15	mediator complex subunit 15	593	0.67
chr12_9760266_9760417	0.25	KLRB1	killer cell lectin-like receptor subfamily B, member 1	141	0.94
chr7_3901538_3901689	0.25	SDK1	sidekick cell adhesion molecule 1	88939	0.1
chr12_70565581_70565732	0.25	CNOT2	CCR4-NOT transcription complex, subunit 2	71118	0.11
chr2_191225245_191225396	0.25	INPP1	inositol polyphosphate-1-phosphatase	4058	0.23
chr12_58135257_58135844	0.25	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	390	0.63
chr6_11727810_11727987	0.25	ADTRP	androgen-dependent TFPI-regulating protein	7991	0.25
chr14_22694848_22695133	0.25	ENSG00000238634	.	84103	0.09
chr6_170581387_170581575	0.25	RP5-1086L22.1		9824	0.18
chr3_114009980_114010222	0.25	TIGIT	T cell immunoreceptor with Ig and ITIM domains	152	0.96
chr19_1469984_1470717	0.25	ENSG00000267317	.	7586	0.07
chr3_193973103_193973434	0.24	CPN2	carboxypeptidase N, polypeptide 2	98779	0.06
chr5_39202680_39202867	0.24	FYB	FYN binding protein	356	0.92
chr14_22961082_22961233	0.24	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	4986	0.11
chrX_72434847_72435271	0.24	NAP1L2	nucleosome assembly protein 1-like 2	375	0.91
chr19_6668929_6669193	0.24	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	1067	0.44
chr2_179914401_179914980	0.24	CCDC141	coiled-coil domain containing 141	96	0.98
chr14_61794973_61795256	0.24	PRKCH	protein kinase C, eta	1483	0.41
chr7_138791837_138792259	0.24	ZC3HAV1	zinc finger CCCH-type, antiviral 1	2052	0.35
chr15_42787196_42787347	0.24	SNAP23	synaptosomal-associated protein, 23kDa	187	0.92
chr3_152002678_152002963	0.24	MBNL1	muscleblind-like splicing regulator 1	14374	0.21
chr17_39810786_39810937	0.24	KRT42P	keratin 42 pseudogene	24017	0.09
chr15_29211317_29211468	0.24	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	178	0.96
chr2_70223879_70224030	0.24	PCBP1-AS1	PCBP1 antisense RNA 1	19	0.97
chr6_44205055_44205796	0.24	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	9399	0.11
chr11_125773182_125774068	0.24	PUS3	pseudouridylate synthase 3	509	0.49
chr10_101088635_101088786	0.24	CNNM1	cyclin M1	146	0.97
chr22_44577376_44577610	0.24	PARVG	parvin, gamma	215	0.96
chr11_1874347_1875032	0.24	LSP1	lymphocyte-specific protein 1	489	0.65
chr13_34116896_34117047	0.24	STARD13	StAR-related lipid transfer (START) domain containing 13	192204	0.03
chr21_34431477_34431628	0.24	OLIG1	oligodendrocyte transcription factor 1	10898	0.17
chr1_226864855_226865089	0.24	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	2204	0.32
chr13_48730530_48730681	0.24	MED4	mediator complex subunit 4	61338	0.11
chr22_50118033_50118520	0.24	ENSG00000223142	.	14049	0.21
chrX_12968759_12969060	0.24	TMSB4X	thymosin beta 4, X-linked	24318	0.17
chr2_109238478_109238884	0.24	LIMS1	LIM and senescent cell antigen-like domains 1	959	0.64
chr2_120989411_120989643	0.24	RALB	v-ral simian leukemia viral oncogene homolog B	8113	0.17
chr6_108051998_108052239	0.24	SCML4	sex comb on midleg-like 4 (Drosophila)	1481	0.55
chr3_50402781_50403356	0.23	XXcos-LUCA11.4		241	0.81
chr2_99080370_99080573	0.23	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	19058	0.22
chr13_26421188_26421471	0.23	AL138815.1	Uncharacterized protein	20732	0.21
chr1_205409872_205410317	0.23	ENSG00000199059	.	7432	0.17
chr11_2158754_2158905	0.23	IGF2	insulin-like growth factor 2 (somatomedin A)	294	0.82
chr15_45005481_45005930	0.23	B2M	beta-2-microglobulin	1990	0.25
chrX_78418409_78418560	0.23	GPR174	G protein-coupled receptor 174	7985	0.33
chr15_78556579_78556885	0.23	DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4	172	0.57
chr14_96087345_96087517	0.23	RP11-1070N10.6		42162	0.13
chr4_40211899_40212136	0.23	RHOH	ras homolog family member H	10053	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.3	GO:0043383	negative T cell selection(GO:0043383)
0.3	0.8	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2	0.7	GO:0002883	hypersensitivity(GO:0002524) regulation of hypersensitivity(GO:0002883)
0.2	0.7	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.1	1.3	GO:0045061	thymic T cell selection(GO:0045061)
0.1	0.4	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1	0.5	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.2	GO:0032632	interleukin-3 production(GO:0032632)
0.1	0.5	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.3	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.8	GO:0002467	germinal center formation(GO:0002467)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.2	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.1	0.2	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.1	0.2	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.4	GO:0070170	regulation of tooth mineralization(GO:0070170)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.5	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.1	0.2	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.1	0.3	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.1	0.1	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.1	0.2	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.2	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1	0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.1	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.1	0.2	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	0.2	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.2	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	1.2	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.2	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.2	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0002830	positive regulation of type 2 immune response(GO:0002830) positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.2	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0001787	natural killer cell proliferation(GO:0001787) regulation of natural killer cell proliferation(GO:0032817)
0.0	0.2	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0001845	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.9	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.5	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.3	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.3	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.2	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.2	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.7	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0032682	negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0051798	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0010939	regulation of necrotic cell death(GO:0010939)
0.0	0.0	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.3	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.2	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.7	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.5	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.3	GO:0042088	T-helper 1 type immune response(GO:0042088)
0.0	0.1	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.1	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	1.1	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.3	GO:0031648	protein destabilization(GO:0031648)
0.0	0.2	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.1	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.4	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.1	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0050856	regulation of T cell receptor signaling pathway(GO:0050856)
0.0	0.1	GO:0046325	negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0	0.2	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.3	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.2	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0032667	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.2	GO:0014002	astrocyte development(GO:0014002)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.3	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0051155	positive regulation of striated muscle cell differentiation(GO:0051155)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.0	GO:0001562	response to protozoan(GO:0001562)
0.0	0.0	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.0	GO:0002220	innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0021554	optic nerve development(GO:0021554)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.2	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:1902117	positive regulation of organelle assembly(GO:1902117)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0050685	regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.0	GO:0030859	polarized epithelial cell differentiation(GO:0030859) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0042441	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.1	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.0	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.1	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0	0.1	GO:0042267	natural killer cell mediated immunity(GO:0002228) natural killer cell mediated cytotoxicity(GO:0042267)
0.0	0.1	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0	0.1	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.1	GO:1903307	positive regulation of regulated secretory pathway(GO:1903307)
0.0	0.0	GO:0033505	floor plate morphogenesis(GO:0033505)
0.0	0.0	GO:0010454	negative regulation of cell fate commitment(GO:0010454)
0.0	0.0	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0006388	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.0	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.0	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.2	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.1	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0021854	hypothalamus development(GO:0021854)
0.0	0.7	GO:0051291	protein heterooligomerization(GO:0051291)
0.0	0.1	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0043029	T cell homeostasis(GO:0043029)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.0	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:2000272	negative regulation of receptor activity(GO:2000272)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0035587	purinergic receptor signaling pathway(GO:0035587)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.1	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.0	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.0	GO:0002921	negative regulation of humoral immune response(GO:0002921)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.3	GO:0006903	vesicle targeting(GO:0006903)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.0	GO:0045911	positive regulation of DNA recombination(GO:0045911)
0.0	0.1	GO:0030903	notochord development(GO:0030903)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.0	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0051458	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0032490	detection of molecule of bacterial origin(GO:0032490)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0015809	arginine transport(GO:0015809)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0045008	depyrimidination(GO:0045008)
0.0	0.0	GO:0035269	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.0	GO:0002902	regulation of B cell apoptotic process(GO:0002902)
0.0	0.0	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.0	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.0	GO:0045824	negative regulation of innate immune response(GO:0045824)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	0.9	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	1.1	GO:0042101	T cell receptor complex(GO:0042101)
0.1	0.7	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	1.0	GO:0001772	immunological synapse(GO:0001772)
0.1	0.3	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1	0.3	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.2	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.6	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.7	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.3	GO:0042611	MHC protein complex(GO:0042611)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.4	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.0	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.5	GO:0016592	mediator complex(GO:0016592)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.3	GO:0031201	SNARE complex(GO:0031201)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.3	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.0	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0	0.0	GO:0000124	SAGA complex(GO:0000124)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.4	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.6	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.3	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1	0.8	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.3	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.3	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.1	0.5	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.4	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	0.7	GO:0032393	MHC class I receptor activity(GO:0032393)
0.1	0.2	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.5	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.6	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.4	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.6	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.2	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.7	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	1.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	1.0	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.8	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	1.5	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0000977	transcription regulatory region sequence-specific DNA binding(GO:0000976) RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.0	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.5	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0030197	extracellular matrix constituent, lubricant activity(GO:0030197)
0.0	0.5	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.2	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.6	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.5	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.0	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.6	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0035240	dopamine binding(GO:0035240)
0.0	0.0	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0008186	RNA-dependent ATPase activity(GO:0008186)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.0	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.0	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.0	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.0	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	1.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	4.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.9	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.7	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.3	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.4	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.3	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.4	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	0.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.2	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.4	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.2	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	1.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	1.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	0.5	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.1	0.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.2	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.5	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.0	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.4	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.0	0.0	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.1	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.4	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.1	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.1	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.0	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells

Results for HSF1

Z-value: 1.30

Motif logo

Transcription factors associated with HSF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the HSF1 motif across conditions

Conditions sorted by the z-value of the HSF1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: