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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HSF2

Z-value: 0.34

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Transcription factors associated with HSF2

Gene Symbol	Gene ID	Gene Info
HSF2 Ensembl NCBI GeneCards UniProt	ENSG00000025156.8	HSF2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HSF2	chr6_122720872_122721541	510	0.857717	-0.80	9.7e-03	Click!
HSF2	chr6_122720489_122720640	127	0.976720	-0.75	1.9e-02	Click!
HSF2	chr6_122729994_122730284	9443	0.258507	-0.73	2.6e-02	Click!
HSF2	chr6_122697833_122697984	22783	0.244110	0.63	7.2e-02	Click!
HSF2	chr6_122721780_122721942	1165	0.602362	0.54	1.4e-01	Click!

Activity of the HSF2 motif across conditions

Conditions sorted by the z-value of the HSF2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_138866633_138866868	0.08	NHSL1	NHS-like 1	98	0.98
chr11_117073075_117073344	0.07	TAGLN	transgelin	620	0.64
chr3_49237110_49237583	0.07	CCDC36	coiled-coil domain containing 36	403	0.74
chr17_79317268_79317735	0.07	TMEM105	transmembrane protein 105	13027	0.13
chr5_119959781_119959971	0.07	PRR16	proline rich 16	7093	0.32
chr19_49590923_49591074	0.07	SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	1261	0.2
chr7_120630066_120630217	0.07	CPED1	cadherin-like and PC-esterase domain containing 1	465	0.82
chr8_123801020_123801334	0.07	ZHX2	zinc fingers and homeoboxes 2	7544	0.22
chr19_36247573_36247956	0.06	HSPB6	heat shock protein, alpha-crystallin-related, B6	146	0.84
chr2_240966839_240966990	0.06	NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	2095	0.24
chr9_130855866_130856180	0.06	RP11-379C10.4		713	0.45
chr12_109123612_109123767	0.06	CORO1C	coronin, actin binding protein, 1C	638	0.67
chr4_22517802_22518220	0.06	GPR125	G protein-coupled receptor 125	334	0.94
chr17_59222769_59222920	0.06	RP11-136H19.1		9519	0.23
chr8_49994861_49995012	0.06	C8orf22	chromosome 8 open reading frame 22	10023	0.32
chrX_47445267_47445418	0.05	TIMP1	TIMP metallopeptidase inhibitor 1	601	0.58
chrX_10727306_10727511	0.05	MID1	midline 1 (Opitz/BBB syndrome)	81629	0.11
chr2_175662837_175662988	0.05	CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	33712	0.18
chr2_85833211_85833461	0.05	TMEM150A	transmembrane protein 150A	3515	0.11
chr11_48085341_48085729	0.05	ENSG00000263693	.	32799	0.16
chrX_114827823_114827974	0.05	PLS3	plastin 3	33	0.98
chr21_27762391_27762594	0.05	AP001596.6		37	0.98
chr14_104123773_104123924	0.05	KLC1	kinesin light chain 1	15844	0.09
chr8_77317569_77317720	0.05	ENSG00000222231	.	139677	0.05
chr10_128352295_128352662	0.05	C10orf90	chromosome 10 open reading frame 90	6537	0.3
chr9_114061378_114061529	0.05	OR2K2	olfactory receptor, family 2, subfamily K, member 2	29260	0.21
chr8_6539493_6539644	0.05	CTD-2541M15.1		26132	0.18
chr9_120467136_120467336	0.05	TLR4	toll-like receptor 4	586	0.75
chr1_32015163_32015427	0.05	RP11-73M7.1		25879	0.13
chr3_70121343_70121525	0.05	RP11-231I13.2		134508	0.05
chr16_88220519_88220720	0.05	BANP	BTG3 associated nuclear protein	216995	0.02
chr3_186539606_186539934	0.05	RP11-573D15.3		14289	0.08
chr6_108020034_108020185	0.05	SCML4	sex comb on midleg-like 4 (Drosophila)	33490	0.22
chrX_48768206_48768869	0.05	SLC35A2	solute carrier family 35 (UDP-galactose transporter), member A2	376	0.74
chr18_12421527_12421678	0.05	SLMO1	slowmo homolog 1 (Drosophila)	317	0.88
chr6_117852473_117852851	0.05	DCBLD1	discoidin, CUB and LCCL domain containing 1	48837	0.12
chr13_96704851_96705002	0.05	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2	711	0.77
chr6_136359997_136360148	0.05	RP13-143G15.3		25704	0.21
chr4_187025490_187026623	0.05	FAM149A	family with sequence similarity 149, member A	175	0.94
chr2_163099011_163099583	0.05	FAP	fibroblast activation protein, alpha	261	0.94
chr3_183167571_183167804	0.05	LINC00888	long intergenic non-protein coding RNA 888	1842	0.19
chr3_99375722_99375873	0.04	COL8A1	collagen, type VIII, alpha 1	18343	0.23
chr5_141700925_141701122	0.04	SPRY4	sprouty homolog 4 (Drosophila)	2724	0.3
chr19_46110497_46110665	0.04	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	5111	0.1
chr2_192500067_192500218	0.04	NABP1	nucleic acid binding protein 1	42720	0.2
chr10_9271510_9271661	0.04	ENSG00000212505	.	572791	0.0
chr22_19165246_19166141	0.04	SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	341	0.82
chr15_30920784_30920977	0.04	ARHGAP11B	Rho GTPase activating protein 11B	2001	0.15
chr1_240501387_240501653	0.04	ENSG00000252317	.	3165	0.32
chr16_74204020_74204218	0.04	PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	126554	0.05
chr8_68304896_68305241	0.04	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	49156	0.18
chr18_32172945_32173175	0.04	DTNA	dystrobrevin, alpha	222	0.97
chr17_64187141_64188685	0.04	CEP112	centrosomal protein 112kDa	60	0.98
chr4_81207576_81207727	0.04	FGF5	fibroblast growth factor 5	19858	0.22
chr7_128171824_128173030	0.04	RP11-274B21.1		1279	0.43
chr1_184857651_184857802	0.04	ENSG00000252222	.	67103	0.11
chr1_158770334_158770485	0.04	OR6N2	olfactory receptor, family 6, subfamily N, member 2	22984	0.14
chr18_10058041_10058330	0.04	ENSG00000263630	.	52991	0.15
chrX_99904753_99905093	0.04	SRPX2	sushi-repeat containing protein, X-linked 2	5708	0.19
chr18_22869258_22869420	0.04	CTD-2006O16.2		12751	0.28
chr21_17489674_17489828	0.04	ENSG00000252273	.	81922	0.11
chr3_149258751_149258902	0.04	ENSG00000252581	.	15408	0.19
chr8_18712658_18712809	0.04	PSD3	pleckstrin and Sec7 domain containing 3	849	0.7
chr9_124888898_124889336	0.04	ENSG00000266583	.	6671	0.17
chr8_15095473_15095828	0.04	SGCZ	sarcoglycan, zeta	198	0.97
chr4_139935567_139935733	0.04	CCRN4L	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	1293	0.33
chr8_48103892_48104098	0.04	IGLV8OR8-1	immunoglobulin lambda variable 8/OR8-1 (pseudogene)	10525	0.24
chr17_13503336_13503489	0.04	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	1832	0.45
chr8_120650260_120650433	0.04	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	674	0.78
chr10_4814227_4814378	0.04	AKR1E2	aldo-keto reductase family 1, member E2	14519	0.27
chr8_93113958_93114847	0.04	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	1052	0.69
chr6_22025873_22026078	0.04	ENSG00000222515	.	59798	0.16
chr1_243906024_243906249	0.04	RP11-370K11.1		2013	0.42
chr2_85936608_85936759	0.04	GNLY	granulysin	14192	0.13
chr19_28500299_28500450	0.04	AC022153.1		72705	0.13
chr20_44750642_44750793	0.04	CD40	CD40 molecule, TNF receptor superfamily member 5	3762	0.23
chrX_102940107_102940387	0.04	MORF4L2	mortality factor 4 like 2	902	0.43
chr7_27848119_27848315	0.04	TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	15460	0.23
chr8_68418566_68418743	0.04	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	162742	0.04
chr4_175750179_175750687	0.04	GLRA3	glycine receptor, alpha 3	32	0.99
chr7_22589223_22589977	0.04	AC002480.3		13356	0.2
chr1_156829720_156830506	0.04	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	494	0.64
chr17_65256580_65256837	0.04	ENSG00000200619	.	7518	0.14
chr9_126164158_126164309	0.04	ENSG00000207991	.	649	0.76
chr6_51848179_51848330	0.04	ENSG00000240641	.	7796	0.27
chr1_23809780_23810676	0.04	ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	443	0.82
chr2_3223937_3224088	0.04	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	81224	0.1
chr6_90142956_90143739	0.04	ANKRD6	ankyrin repeat domain 6	415	0.85
chr2_169733635_169733786	0.04	SPC25	SPC25, NDC80 kinetochore complex component	13245	0.2
chrX_152989287_152989823	0.04	BCAP31	B-cell receptor-associated protein 31	6	0.92
chr11_68426343_68426647	0.04	GAL	galanin/GMAP prepropeptide	25448	0.16
chr13_107572015_107572438	0.04	ENSG00000239050	.	55148	0.17
chr10_65558718_65559094	0.04	REEP3	receptor accessory protein 3	277783	0.01
chr19_17345728_17346858	0.04	OCEL1	occludin/ELL domain containing 1	7228	0.08
chr16_29232306_29232457	0.04	RP11-231C14.6		91290	0.06
chr4_146403033_146403938	0.04	SMAD1	SMAD family member 1	153	0.96
chr12_76153409_76153694	0.04	ENSG00000264062	.	35230	0.2
chr11_134818938_134819089	0.04	AP003062.1	CDNA FLJ27342 fis, clone TST02993; Uncharacterized protein	36233	0.24
chr19_49521308_49522757	0.04	LHB	luteinizing hormone beta polypeptide	1694	0.14
chr4_48702119_48702270	0.03	FRYL	FRY-like	19006	0.24
chrX_2882242_2882393	0.03	ARSE	arylsulfatase E (chondrodysplasia punctata 1)	6	0.98
chr1_99646133_99646284	0.03	LPPR4	Lipid phosphate phosphatase-related protein type 4	83301	0.11
chr12_51702265_51702437	0.03	BIN2	bridging integrator 2	15548	0.14
chr2_16831792_16832248	0.03	FAM49A	family with sequence similarity 49, member A	15076	0.3
chr10_44879097_44879375	0.03	CXCL12	chemokine (C-X-C motif) ligand 12	1255	0.52
chr5_178367547_178367761	0.03	ZNF454	zinc finger protein 454	538	0.73
chr17_66050514_66050792	0.03	KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	17543	0.17
chr11_2972850_2973001	0.03	ENSG00000207008	.	12198	0.12
chr11_35627316_35627467	0.03	FJX1	four jointed box 1 (Drosophila)	12344	0.23
chr6_158490615_158490766	0.03	SYNJ2	synaptojanin 2	8022	0.22
chr7_90896542_90897161	0.03	FZD1	frizzled family receptor 1	3068	0.42
chr4_163085753_163086130	0.03	FSTL5	follistatin-like 5	754	0.8
chr10_95302144_95302315	0.03	FFAR4	free fatty acid receptor 4	24193	0.14
chr1_155830714_155830915	0.03	SYT11	synaptotagmin XI	1467	0.25
chr3_66519543_66519694	0.03	LRIG1	leucine-rich repeats and immunoglobulin-like domains 1	31738	0.24
chr6_3911647_3911836	0.03	FAM50B	family with sequence similarity 50, member B	62119	0.1
chr2_239800244_239800395	0.03	TWIST2	twist family bHLH transcription factor 2	43646	0.15
chr11_110967676_110967838	0.03	ENSG00000200168	.	56825	0.15
chr11_106913477_106913628	0.03	GUCY1A2	guanylate cyclase 1, soluble, alpha 2	24302	0.28
chr2_109273663_109273868	0.03	LIMS1	LIM and senescent cell antigen-like domains 1	2256	0.33
chr17_43170825_43171067	0.03	PLCD3	phospholipase C, delta 3	19970	0.1
chr4_16969555_16969706	0.03	LDB2	LIM domain binding 2	69198	0.14
chr1_19809409_19809560	0.03	CAPZB	capping protein (actin filament) muscle Z-line, beta	1095	0.47
chr8_18709187_18709437	0.03	PSD3	pleckstrin and Sec7 domain containing 3	2572	0.36
chr5_31806525_31806676	0.03	PDZD2	PDZ domain containing 2	7569	0.14
chr9_18496529_18496680	0.03	ADAMTSL1	ADAMTS-like 1	22373	0.25
chr11_27720314_27720465	0.03	BDNF	brain-derived neurotrophic factor	825	0.7
chr5_15620667_15620944	0.03	FBXL7	F-box and leucine-rich repeat protein 7	4714	0.28
chr17_19172840_19172991	0.03	EPN2	epsin 2	11682	0.12
chr10_104536223_104536534	0.03	WBP1L	WW domain binding protein 1-like	372	0.83
chr8_97744511_97744662	0.03	CPQ	carboxypeptidase Q	28616	0.25
chr2_133425157_133425453	0.03	LYPD1	LY6/PLAUR domain containing 1	2473	0.33
chr12_66635842_66635993	0.03	ENSG00000266539	.	6515	0.17
chr18_56084210_56084361	0.03	RP11-845C23.3		16971	0.16
chr18_499765_500605	0.03	COLEC12	collectin sub-family member 12	537	0.79
chr2_231692712_231693467	0.03	ITM2C	integral membrane protein 2C	36265	0.14
chr15_70011457_70011608	0.03	ENSG00000238870	.	11629	0.27
chr11_65200671_65200881	0.03	ENSG00000245532	.	11153	0.12
chr3_65130539_65130690	0.03	ENSG00000264871	.	88044	0.1
chr2_192711472_192711842	0.03	SDPR	serum deprivation response	324	0.55
chr12_116498850_116499001	0.03	ENSG00000200665	.	21450	0.22
chr16_69960974_69961125	0.03	WWP2	WW domain containing E3 ubiquitin protein ligase 2	2156	0.25
chr4_169564167_169564409	0.03	RP11-610J23.1		5450	0.22
chr2_189652663_189652814	0.03	DIRC1	disrupted in renal carcinoma 1	2093	0.42
chr21_43537496_43537668	0.03	C21orf128	chromosome 21 open reading frame 128	8938	0.21
chr21_46714077_46714379	0.03	ENSG00000215447	.	6261	0.19
chr11_133920657_133920816	0.03	JAM3	junctional adhesion molecule 3	18084	0.22
chr2_110658435_110658586	0.03	LIMS3	LIM and senescent cell antigen-like domains 3	2242	0.42
chr8_17518406_17518557	0.03	MTUS1	microtubule associated tumor suppressor 1	15357	0.17
chr11_111607263_111607414	0.03	PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	18424	0.17
chr11_128339811_128339962	0.03	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	35403	0.2
chr5_14448576_14448727	0.03	TRIO	trio Rho guanine nucleotide exchange factor	39906	0.21
chr12_77272013_77272805	0.03	CSRP2	cysteine and glycine-rich protein 2	356	0.56
chr10_94725160_94725374	0.03	EXOC6	exocyst complex component 6	31964	0.2
chr8_23220998_23221149	0.03	LOXL2	lysyl oxidase-like 2	7566	0.18
chr1_98864645_98864799	0.03	ENSG00000221777	.	25781	0.28
chr21_17681697_17681848	0.03	ENSG00000201025	.	24683	0.27
chr14_77493944_77494823	0.03	IRF2BPL	interferon regulatory factor 2 binding protein-like	651	0.73
chr4_88419703_88419884	0.03	SPARCL1	SPARC-like 1 (hevin)	29978	0.17
chr20_48671365_48671516	0.03	UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	58236	0.09
chr1_27098835_27099154	0.03	ARID1A	AT rich interactive domain 1A (SWI-like)	461	0.73
chr2_111228087_111228238	0.03	LIMS3	LIM and senescent cell antigen-like-containing domain protein 3; Uncharacterized protein; cDNA FLJ59124, highly similar to Particularly interesting newCys-His protein; cDNA, FLJ79109, highly similar to Particularly interesting newCys-His protein	2231	0.25
chr2_133174260_133174576	0.03	GPR39	G protein-coupled receptor 39	271	0.93
chr17_70339032_70339432	0.03	SOX9	SRY (sex determining region Y)-box 9	222071	0.02
chr4_184264353_184264576	0.03	ENSG00000238596	.	14013	0.14
chr13_67928310_67928532	0.03	PCDH9	protocadherin 9	123953	0.06
chr12_63078503_63078654	0.03	ENSG00000238475	.	33623	0.17
chrX_13751428_13751579	0.03	TRAPPC2	trafficking protein particle complex 2	1172	0.37
chr11_111413272_111413423	0.03	LAYN	layilin	1070	0.38
chr14_27066556_27066724	0.03	NOVA1	neuro-oncological ventral antigen 1	2	0.96
chr16_14109675_14109826	0.03	MKL2	MKL/myocardin-like 2	55428	0.14
chr3_29800464_29800615	0.03	RBMS3-AS2	RBMS3 antisense RNA 2	116239	0.07
chr8_13014143_13014294	0.03	ENSG00000200630	.	3469	0.29
chr4_159925007_159925158	0.03	ENSG00000221314	.	3640	0.25
chr1_64245163_64245314	0.03	ROR1	receptor tyrosine kinase-like orphan receptor 1	5524	0.3
chr3_189794073_189794333	0.03	ENSG00000265045	.	37520	0.14
chr7_87229218_87230455	0.03	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	336	0.9
chr3_114168204_114168554	0.03	ZBTB20	zinc finger and BTB domain containing 20	5151	0.29
chr2_43188289_43188440	0.03	ENSG00000207087	.	130268	0.05
chr9_131085826_131085977	0.03	COQ4	coenzyme Q4	770	0.33
chr16_47813458_47814031	0.03	PHKB	phosphorylase kinase, beta	83361	0.1
chr6_151646770_151647383	0.03	AKAP12	A kinase (PRKA) anchor protein 12	253	0.88
chr17_60868949_60869438	0.03	MARCH10	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	14808	0.23
chr4_19778605_19778779	0.03	SLIT2	slit homolog 2 (Drosophila)	476191	0.01
chr14_38091284_38091435	0.03	TTC6	tetratricopeptide repeat domain 6	89	0.98
chr8_39939130_39939407	0.03	C8orf4	chromosome 8 open reading frame 4	71721	0.11
chr10_92794688_92794839	0.03	ENSG00000201604	.	112171	0.06
chr7_116141197_116141631	0.03	CAV2	caveolin 2	1580	0.29
chr2_238186522_238186673	0.03	AC112715.2	Uncharacterized protein	20863	0.24
chr4_41157110_41157449	0.03	ENSG00000207198	.	41320	0.14
chr12_65702776_65702927	0.03	MSRB3	methionine sulfoxide reductase B3	17804	0.22
chr3_184406321_184406472	0.03	MAGEF1	melanoma antigen family F, 1	23440	0.22
chr10_29980674_29981313	0.03	ENSG00000222092	.	19851	0.22
chr17_53347750_53347901	0.03	HLF	hepatic leukemia factor	2648	0.31
chr5_38783776_38783927	0.03	RP11-122C5.3		169	0.97
chrX_46772292_46772991	0.03	JADE3	jade family PHD finger 3	410	0.86
chr17_79197162_79197682	0.03	AZI1	5-azacytidine induced 1	623	0.55
chr20_9141897_9142059	0.03	PLCB4	phospholipase C, beta 4	5027	0.33
chr1_204010490_204010911	0.03	SOX13	SRY (sex determining region Y)-box 13	32032	0.15
chr8_97596791_97596942	0.03	SDC2	syndecan 2	307	0.94

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.0	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	GO:0052308	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)