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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HSF4

Z-value: 1.01

Motif logo

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 HSF4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
HSF4chr16_67196775_671970024000.593118-0.694.1e-02Click!
HSF4chr16_67198733_671988971000.901692-0.665.5e-02Click!
HSF4chr16_67199121_671992722320.798377-0.581.0e-01Click!
HSF4chr16_67197260_671983365100.518764-0.117.7e-01Click!

Activity of the HSF4 motif across conditions

Conditions sorted by the z-value of the HSF4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr19_16493544_16493695 0.55 ENSG00000243745
 .
 16151
 0.14
chrX_12968759_12969060 0.49 TMSB4X
 thymosin beta 4, X-linked
 24318
 0.17
chrY_7158530_7158855 0.47 PRKY
 protein kinase, Y-linked, pseudogene
 16338
 0.2
chr1_207997059_207997359 0.45 ENSG00000203709
 .
 21341
 0.22
chrX_12925475_12925626 0.45 TLR8
 toll-like receptor 8
 792
 0.45
chr14_81425506_81425657 0.45 CEP128
 centrosomal protein 128kDa
 247
 0.94
chrY_15815919_15816489 0.43 TMSB4Y
 thymosin beta 4, Y-linked
 757
 0.72
chr16_84628728_84628899 0.41 RP11-61F12.1
814
 0.61
chr1_145454279_145454446 0.40 TXNIP
 thioredoxin interacting protein
 15056
 0.1
chr16_79320926_79321088 0.38 ENSG00000222244
 .
 22656
 0.27
chr20_48183167_48183318 0.38 PTGIS
 prostaglandin I2 (prostacyclin) synthase
 1441
 0.45
chr16_84582211_84582362 0.37 TLDC1
 TBC/LysM-associated domain containing 1
 5353
 0.2
chr17_45812399_45812645 0.35 TBX21
 T-box 21
 1912
 0.27
chr1_164695126_164695277 0.35 RP11-477H21.2
45879
 0.13
chr2_85936608_85936759 0.35 GNLY
 granulysin
 14192
 0.13
chr19_50003533_50003936 0.35 hsa-mir-150
 hsa-mir-150
 47
 0.8
chr2_176344322_176344473 0.34 ENSG00000221347
 .
 149296
 0.04
chrX_123094531_123095374 0.34 STAG2
 stromal antigen 2
 212
 0.95
chr6_57043038_57043189 0.33 RP11-203B9.4
4079
 0.22
chr6_30459024_30459175 0.33 HLA-E
 major histocompatibility complex, class I, E
 1855
 0.27
chr3_95746418_95746569 0.32 ENSG00000221477
 .
 139253
 0.05
chr19_16438433_16439148 0.32 KLF2
 Kruppel-like factor 2
 3139
 0.19
chr6_31323146_31323355 0.31 HLA-B
 major histocompatibility complex, class I, B
 1714
 0.23
chr5_72485454_72485605 0.31 TMEM174
 transmembrane protein 174
 16507
 0.18
chr11_122933023_122933174 0.31 HSPA8
 heat shock 70kDa protein 8
 38
 0.96
chrX_41777222_41777373 0.31 ENSG00000251807
 .
 1305
 0.5
chr1_25246548_25246699 0.31 RUNX3
 runt-related transcription factor 3
 8989
 0.23
chr2_113545549_113545700 0.31 IL1A
 interleukin 1, alpha
 3457
 0.21
chr17_33863104_33863360 0.31 SLFN12L
 schlafen family member 12-like
 1648
 0.24
chrX_152989287_152989823 0.30 BCAP31
 B-cell receptor-associated protein 31
 6
 0.92
chr1_161493792_161494541 0.30 HSPA6
 heat shock 70kDa protein 6 (HSP70B')
 130
 0.94
chr11_104788188_104788675 0.30 RP11-693N9.2
7789
 0.2
chr22_23528239_23528390 0.30 BCR
 breakpoint cluster region
 5762
 0.16
chr8_38323527_38324266 0.30 FGFR1
 fibroblast growth factor receptor 1
 285
 0.89
chr15_81593596_81593907 0.30 IL16
 interleukin 16
 1994
 0.33
chr9_21031432_21031950 0.30 PTPLAD2
 protein tyrosine phosphatase-like A domain containing 2
 56
 0.98
chr20_50148880_50149119 0.29 NFATC2
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
 10259
 0.28
chr1_198629639_198630096 0.29 RP11-553K8.5
6323
 0.26
chr1_206718342_206718493 0.29 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 12076
 0.16
chr15_81576793_81576944 0.29 IL16
 interleukin 16
 12386
 0.21
chr4_111709350_111709501 0.29 ENSG00000251808
 .
 65201
 0.13
chrX_55545866_55546017 0.29 USP51
 ubiquitin specific peptidase 51
 30306
 0.17
chr17_74137094_74137375 0.29 FOXJ1
 forkhead box J1
 146
 0.74
chr12_122228062_122228376 0.29 RHOF
 ras homolog family member F (in filopodia)
 3047
 0.21
chr22_37178306_37178457 0.29 IFT27
 intraflagellar transport 27 homolog (Chlamydomonas)
 6184
 0.17
chr1_101187693_101187844 0.28 VCAM1
 vascular cell adhesion molecule 1
 2448
 0.39
chr19_17958522_17959083 0.28 JAK3
 Janus kinase 3
 24
 0.96
chr2_69003816_69004024 0.28 ARHGAP25
 Rho GTPase activating protein 25
 1848
 0.42
chr6_167566709_167567175 0.28 TCP10L2
 t-complex 10-like 2
 3974
 0.21
chr1_108484043_108484194 0.28 VAV3-AS1
 VAV3 antisense RNA 1
 22947
 0.2
chrX_15767915_15768266 0.27 CA5B
 carbonic anhydrase VB, mitochondrial
 3
 0.98
chr17_29877127_29877670 0.27 ENSG00000207614
 .
 9617
 0.11
chr12_2903621_2904135 0.27 FKBP4
 FK506 binding protein 4, 59kDa
 241
 0.88
chr9_110975706_110975857 0.27 ENSG00000222512
 .
 145428
 0.05
chrX_70502857_70503125 0.27 NONO
 non-POU domain containing, octamer-binding
 51
 0.97
chr19_19728555_19728718 0.27 PBX4
 pre-B-cell leukemia homeobox 4
 1089
 0.37
chr7_50350295_50350528 0.27 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 2093
 0.45
chrX_133687659_133687810 0.27 ENSG00000223749
 .
 6993
 0.12
chr2_69470356_69470507 0.27 ENSG00000199460
 .
 60422
 0.11
chr4_7829564_7829715 0.27 AFAP1
 actin filament associated protein 1
 44170
 0.15
chr7_155283292_155284101 0.26 AC008060.5
19282
 0.17
chr14_22982783_22983297 0.25 TRAJ15
 T cell receptor alpha joining 15
 15540
 0.1
chr18_77165970_77166171 0.25 NFATC1
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
 5678
 0.26
chr7_3083968_3084119 0.25 CARD11
 caspase recruitment domain family, member 11
 464
 0.86
chr9_78508950_78509101 0.25 PCSK5
 proprotein convertase subtilisin/kexin type 5
 3404
 0.31
chr8_23313563_23313898 0.24 ENTPD4
 ectonucleoside triphosphate diphosphohydrolase 4
 1430
 0.42
chr19_54875923_54876565 0.24 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 170
 0.91
chr1_145454503_145454819 0.24 TXNIP
 thioredoxin interacting protein
 15355
 0.1
chr1_54009379_54009530 0.23 DMRTB1
 DMRT-like family B with proline-rich C-terminal, 1
 84382
 0.08
chr10_95262845_95263083 0.23 CEP55
 centrosomal protein 55kDa
 3803
 0.2
chr20_57722405_57722705 0.23 ZNF831
 zinc finger protein 831
 43520
 0.15
chr11_20384960_20385960 0.23 HTATIP2
 HIV-1 Tat interactive protein 2, 30kDa
 60
 0.98
chr15_42837275_42837426 0.23 LRRC57
 leucine rich repeat containing 57
 3620
 0.15
chr17_8820194_8820345 0.23 PIK3R5
 phosphoinositide-3-kinase, regulatory subunit 5
 4435
 0.27
chr19_55014108_55014308 0.23 LAIR2
 leukocyte-associated immunoglobulin-like receptor 2
 85
 0.94
chr9_34988963_34989411 0.23 DNAJB5
 DnaJ (Hsp40) homolog, subfamily B, member 5
 451
 0.77
chr1_119627265_119627416 0.23 WARS2-IT1
 WARS2 intronic transcript 1 (non-protein coding)
 37312
 0.16
chr9_93914044_93914195 0.23 AUH
 AU RNA binding protein/enoyl-CoA hydratase
 210058
 0.03
chr3_79625949_79626100 0.23 ENSG00000216116
 .
 7810
 0.3
chr6_130992857_130993008 0.22 ENSG00000202438
 .
 97675
 0.08
chr1_1711747_1711898 0.22 NADK
 NAD kinase
 314
 0.86
chr13_110951342_110951493 0.22 COL4A2
 collagen, type IV, alpha 2
 6742
 0.23
chr7_14019556_14019707 0.22 ETV1
 ets variant 1
 6435
 0.28
chrY_21906956_21907224 0.22 KDM5D
 lysine (K)-specific demethylase 5D
 265
 0.96
chr15_63789062_63789213 0.22 USP3
 ubiquitin specific peptidase 3
 7656
 0.25
chr9_132477050_132477230 0.22 RP11-483H20.6
3774
 0.19
chr4_26300916_26301067 0.22 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 20293
 0.28
chr8_56919486_56919637 0.22 ENSG00000241997
 .
 15311
 0.15
chr15_101212076_101212240 0.22 ENSG00000212306
 .
 33590
 0.16
chr3_71779214_71779365 0.22 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 941
 0.61
chr1_66797787_66798583 0.22 PDE4B
 phosphodiesterase 4B, cAMP-specific
 313
 0.94
chr6_14109075_14109337 0.21 CD83
 CD83 molecule
 8666
 0.27
chr1_206753637_206754165 0.21 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 23408
 0.13
chr2_198651086_198651566 0.21 BOLL
 boule-like RNA-binding protein
 28
 0.98
chr8_123618804_123618955 0.21 ENSG00000238901
 .
 64651
 0.14
chr3_119421432_119421650 0.21 MAATS1
 MYCBP-associated, testis expressed 1
 328
 0.87
chr9_139433085_139433378 0.21 RP11-413M3.4
4102
 0.11
chr14_72052659_72052844 0.21 SIPA1L1
 signal-induced proliferation-associated 1 like 1
 247
 0.96
chr19_49164249_49164514 0.21 NTN5
 netrin 5
 11883
 0.08
chr15_63341000_63341752 0.21 RP11-244F12.3
71
 0.83
chr2_177361445_177361596 0.21 ENSG00000221304
 .
 113216
 0.06
chr2_33391520_33391792 0.21 LTBP1
 latent transforming growth factor beta binding protein 1
 31932
 0.22
chr1_2163627_2164198 0.21 SKI
 v-ski avian sarcoma viral oncogene homolog
 3778
 0.16
chr13_99966619_99966770 0.20 GPR183
 G protein-coupled receptor 183
 7035
 0.21
chr5_141737086_141737313 0.20 AC005592.2
4091
 0.29
chr19_18415340_18416257 0.20 LSM4
 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 11271
 0.09
chr11_65837004_65837255 0.20 RP11-1167A19.2
 Uncharacterized protein
 39
 0.92
chr20_30777439_30777911 0.20 PLAGL2
 pleiomorphic adenoma gene-like 2
 17919
 0.14
chr1_212731391_212732317 0.20 ATF3
 activating transcription factor 3
 6822
 0.21
chr19_18627573_18627724 0.20 ELL
 elongation factor RNA polymerase II
 5289
 0.1
chr22_24837615_24837766 0.20 ADORA2A
 adenosine A2a receptor
 8882
 0.18
chr4_1194452_1194845 0.20 SPON2
 spondin 2, extracellular matrix protein
 4228
 0.16
chr11_48042023_48042428 0.20 AC103828.1
4818
 0.24
chr9_19441802_19441976 0.20 RP11-363E7.4
11318
 0.18
chr5_52021818_52021969 0.20 ITGA1
 integrin, alpha 1
 61837
 0.12
chr3_113252540_113252793 0.20 SIDT1
 SID1 transmembrane family, member 1
 1448
 0.4
chr19_50423027_50423178 0.20 NUP62
 nucleoporin 62kDa
 2184
 0.12
chr19_4915707_4915936 0.20 ARRDC5
 arrestin domain containing 5
 12942
 0.12
chr3_72150163_72150348 0.20 ENSG00000212070
 .
 161324
 0.04
chr6_45462799_45462992 0.19 RUNX2
 runt-related transcription factor 2
 72673
 0.11
chr6_29797302_29797453 0.19 HLA-G
 major histocompatibility complex, class I, G
 1755
 0.34
chr2_135052691_135052842 0.19 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 40936
 0.19
chr14_22694848_22695133 0.19 ENSG00000238634
 .
 84103
 0.09
chr11_117821485_117821636 0.19 TMPRSS13
 transmembrane protease, serine 13
 21386
 0.15
chr16_1019853_1020655 0.19 LMF1
 lipase maturation factor 1
 612
 0.62
chr12_124768084_124768235 0.19 FAM101A
 family with sequence similarity 101, member A
 5551
 0.28
chr19_10927021_10927186 0.19 ENSG00000207752
 .
 1069
 0.38
chr19_47217120_47217717 0.19 PRKD2
 protein kinase D2
 138
 0.91
chrX_9622413_9622564 0.19 GPR143
 G protein-coupled receptor 143
 111516
 0.06
chr7_138791837_138792259 0.19 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 2052
 0.35
chr10_111838058_111838209 0.19 ADD3
 adducin 3 (gamma)
 70411
 0.1
chr16_47813458_47814031 0.19 PHKB
 phosphorylase kinase, beta
 83361
 0.1
chr6_41906196_41906466 0.19 CCND3
 cyclin D3
 2133
 0.22
chr8_142237735_142237886 0.19 SLC45A4
 solute carrier family 45, member 4
 859
 0.55
chr19_859742_860228 0.18 CFD
 complement factor D (adipsin)
 295
 0.77
chr19_36389493_36389866 0.18 NFKBID
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
 1873
 0.17
chr1_9714142_9714379 0.18 C1orf200
 chromosome 1 open reading frame 200
 384
 0.82
chr10_104913694_104913845 0.18 NT5C2
 5'-nucleotidase, cytosolic II
 385
 0.89
chr18_66469346_66469497 0.18 CCDC102B
 coiled-coil domain containing 102B
 3769
 0.28
chr18_6627846_6627997 0.18 ENSG00000243591
 .
 26382
 0.19
chr12_58235429_58235580 0.18 CTDSP2
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
 3813
 0.11
chr19_2049519_2050886 0.18 MKNK2
 MAP kinase interacting serine/threonine kinase 2
 650
 0.55
chr1_203279239_203279390 0.18 BTG2
 BTG family, member 2
 4650
 0.19
chr2_182245315_182245466 0.18 ENSG00000266705
 .
 75011
 0.11
chr10_11212951_11213685 0.18 RP3-323N1.2
21
 0.98
chr6_112082790_112082941 0.18 FYN
 FYN oncogene related to SRC, FGR, YES
 1745
 0.48
chr3_130648074_130648225 0.18 RP11-39E3.3
671
 0.43
chrX_54071307_54071816 0.18 PHF8
 PHD finger protein 8
 121
 0.97
chrX_12995326_12995601 0.18 TMSB4X
 thymosin beta 4, X-linked
 1686
 0.43
chr7_46644240_46644391 0.18 AC011294.3
 Uncharacterized protein
 92405
 0.1
chr15_28412952_28413117 0.18 HERC2
 HECT and RLD domain containing E3 ubiquitin protein ligase 2
 6535
 0.28
chr17_80398389_80398540 0.18 HEXDC
 hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
 3859
 0.1
chr19_17515989_17516450 0.18 BST2
 bone marrow stromal cell antigen 2
 238
 0.54
chr12_117298021_117298350 0.17 HRK
 harakiri, BCL2 interacting protein (contains only BH3 domain)
 20708
 0.2
chr2_100881771_100881922 0.17 LONRF2
 LON peptidase N-terminal domain and ring finger 2
 44121
 0.17
chrX_15768764_15768915 0.17 CA5B
 carbonic anhydrase VB, mitochondrial
 746
 0.66
chr1_202895737_202896386 0.17 KLHL12
 kelch-like family member 12
 329
 0.82
chr3_138893153_138893304 0.17 MRPS22
 mitochondrial ribosomal protein S22
 63982
 0.12
chr14_99699360_99699511 0.17 AL109767.1
29850
 0.18
chr2_101541390_101541618 0.17 NPAS2
 neuronal PAS domain protein 2
 104
 0.97
chr15_38855839_38856970 0.17 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 432
 0.84
chr5_100182433_100182584 0.17 ENSG00000221263
 .
 30239
 0.22
chr2_65284469_65284714 0.17 CEP68
 centrosomal protein 68kDa
 992
 0.53
chr1_158800341_158800492 0.17 MNDA
 myeloid cell nuclear differentiation antigen
 691
 0.7
chr8_28269075_28269620 0.17 ENSG00000207361
 .
 4618
 0.15
chrX_153360358_153360509 0.17 MECP2
 methyl CpG binding protein 2 (Rett syndrome)
 2003
 0.26
chr5_79331612_79331763 0.17 THBS4
 thrombospondin 4
 159
 0.96
chr19_18414393_18414628 0.17 LSM4
 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 12559
 0.09
chr8_41593946_41594097 0.17 ANK1
 ankyrin 1, erythrocytic
 30324
 0.15
chr10_117577321_117577472 0.17 GFRA1
 GDNF family receptor alpha 1
 437911
 0.01
chr9_132220609_132220886 0.17 ENSG00000264298
 .
 20088
 0.2
chr2_144008418_144008569 0.17 RP11-190J23.1
78752
 0.11
chr12_125399791_125400355 0.17 ENSG00000265345
 .
 20
 0.69
chr21_34431477_34431628 0.17 OLIG1
 oligodendrocyte transcription factor 1
 10898
 0.17
chr1_61637615_61637766 0.17 RP4-802A10.1
47285
 0.17
chr12_54688354_54688505 0.17 NFE2
 nuclear factor, erythroid 2
 1113
 0.27
chr17_63025367_63025525 0.17 RP11-583F2.5
22581
 0.15
chr2_113599646_113599797 0.17 ENSG00000221541
 .
 2167
 0.27
chr1_93508255_93508475 0.17 ENSG00000251837
 .
 15302
 0.13
chr14_99719284_99719435 0.17 AL109767.1
9926
 0.22
chrX_12990488_12990859 0.17 TMSB4X
 thymosin beta 4, X-linked
 2554
 0.33
chr8_19371412_19371563 0.16 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 87889
 0.1
chr1_27153904_27154578 0.16 ZDHHC18
 zinc finger, DHHC-type containing 18
 1040
 0.39
chr3_30852560_30852711 0.16 GADL1
 glutamate decarboxylase-like 1
 83518
 0.1
chr11_59537081_59537232 0.16 STX3
 syntaxin 3
 14231
 0.13
chr9_129183867_129184018 0.16 ENSG00000252985
 .
 5230
 0.22
chr9_470290_470809 0.16 KANK1
 KN motif and ankyrin repeat domains 1
 258
 0.49
chr21_44394961_44395127 0.16 PKNOX1
 PBX/knotted 1 homeobox 1
 293
 0.89
chr5_151098480_151098631 0.16 ENSG00000222102
 .
 14416
 0.14
chr2_175458554_175459187 0.16 WIPF1
 WAS/WASL interacting protein family, member 1
 3623
 0.22
chr5_127577032_127577183 0.16 FBN2
 fibrillin 2
 97776
 0.08
chr3_108542080_108542294 0.16 TRAT1
 T cell receptor associated transmembrane adaptor 1
 568
 0.83
chr19_11159843_11160026 0.16 SMARCA4
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
 9577
 0.14
chr17_34610642_34610793 0.16 CCL3L1
 chemokine (C-C motif) ligand 3-like 1
 15002
 0.13
chr1_226001552_226001703 0.16 EPHX1
 epoxide hydrolase 1, microsomal (xenobiotic)
 3791
 0.18
chr4_84030444_84030764 0.16 PLAC8
 placenta-specific 8
 392
 0.89
chr1_57038997_57039148 0.15 PPAP2B
 phosphatidic acid phosphatase type 2B
 6169
 0.3
chr4_41574676_41574848 0.15 LIMCH1
 LIM and calponin homology domains 1
 34571
 0.21
chr1_204332360_204332939 0.15 PLEKHA6
 pleckstrin homology domain containing, family A member 6
 3605
 0.22
chr11_75272983_75274329 0.15 SERPINH1
 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
 216
 0.91

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 0.3 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1 0.3 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.1 0.2 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1 0.4 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1 0.2 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.1 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.1 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.1 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.2 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.1 GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.2 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0043173 nucleotide salvage(GO:0043173)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.0 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0000966 RNA 5'-end processing(GO:0000966)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0050901 leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.0 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.3 GO:0019674 NAD metabolic process(GO:0019674)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.2 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.0 GO:2000757 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.1 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.1 GO:0042745 circadian sleep/wake cycle(GO:0042745)
0.0 0.0 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0042119 neutrophil activation(GO:0042119)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.2 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267)
0.0 0.0 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.0 GO:0032059 bleb(GO:0032059)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0050542 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.4 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.3 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling