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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for IKZF2

Z-value: 1.11

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Transcription factors associated with IKZF2

Gene Symbol	Gene ID	Gene Info
IKZF2 Ensembl NCBI GeneCards UniProt	ENSG00000030419.12	IKZF2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
IKZF2	chr2_213969171_213969322	44107	0.187180	0.63	6.8e-02	Click!
IKZF2	chr2_213969618_213969769	43660	0.188675	0.63	7.1e-02	Click!
IKZF2	chr2_213983567_213983718	29711	0.237098	0.57	1.1e-01	Click!
IKZF2	chr2_213983796_213984145	29383	0.238239	0.51	1.6e-01	Click!
IKZF2	chr2_214016688_214017732	59	0.986711	0.49	1.8e-01	Click!

Activity of the IKZF2 motif across conditions

Conditions sorted by the z-value of the IKZF2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_110720958_110721647	0.33	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	1816	0.41
chr12_116872831_116873001	0.31	ENSG00000264037	.	6793	0.3
chr3_29327656_29328192	0.28	RBMS3-AS3	RBMS3 antisense RNA 3	4293	0.26
chr18_74277400_74278128	0.28	LINC00908	long intergenic non-protein coding RNA 908	36890	0.17
chr18_20558047_20558453	0.28	RBBP8	retinoblastoma binding protein 8	9445	0.15
chr11_79861921_79862072	0.28	ENSG00000200146	.	377008	0.01
chr3_136649286_136649636	0.25	NCK1	NCK adaptor protein 1	117	0.97
chr3_172240144_172241280	0.25	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	553	0.83
chr3_155108862_155109013	0.25	ENSG00000272096	.	46675	0.16
chr9_34745557_34745708	0.25	FAM205A	family with sequence similarity 205, member A	16168	0.13
chr3_5055440_5055591	0.25	BHLHE40-AS1	BHLHE40 antisense RNA 1	33869	0.15
chr12_32635081_32635232	0.25	FGD4	FYVE, RhoGEF and PH domain containing 4	3750	0.26
chr20_11898508_11899014	0.24	BTBD3	BTB (POZ) domain containing 3	196	0.82
chr14_103887907_103888058	0.24	MARK3	MAP/microtubule affinity-regulating kinase 3	35406	0.12
chr7_93694115_93694266	0.24	BET1	Bet1 golgi vesicular membrane trafficking protein	60496	0.13
chr21_39756340_39756646	0.23	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	87645	0.09
chrX_73071645_73072457	0.23	RP13-216E22.5		117269	0.06
chr10_21807539_21808360	0.23	SKIDA1	SKI/DACH domain containing 1	1101	0.4
chr1_47489778_47489953	0.22	CYP4X1	cytochrome P450, family 4, subfamily X, polypeptide 1	625	0.75
chr8_51783438_51783589	0.22	ENSG00000201316	.	144068	0.05
chr1_77751257_77751408	0.22	AK5	adenylate kinase 5	2568	0.34
chr7_129255259_129255410	0.22	NRF1	nuclear respiratory factor 1	3737	0.29
chr5_71806938_71807120	0.21	ZNF366	zinc finger protein 366	3475	0.33
chr21_34415086_34415237	0.21	OLIG2	oligodendrocyte lineage transcription factor 2	16918	0.17
chr18_19192929_19193396	0.21	SNRPD1	small nuclear ribonucleoprotein D1 polypeptide 16kDa	870	0.52
chr21_27944686_27945456	0.21	CYYR1	cysteine/tyrosine-rich 1	424	0.91
chr21_16388120_16388271	0.21	NRIP1	nuclear receptor interacting protein 1	13506	0.22
chr16_85160610_85160761	0.21	FAM92B	family with sequence similarity 92, member B	14571	0.21
chr6_150083012_150083330	0.21	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	11991	0.14
chr1_9600473_9600668	0.21	SLC25A33	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	1029	0.58
chr12_96839645_96840068	0.21	ENSG00000263364	.	2598	0.28
chr2_158694717_158695163	0.21	ACVR1	activin A receptor, type I	101	0.97
chr6_157104323_157104474	0.21	RP11-230C9.3		2809	0.25
chr2_178032482_178032633	0.21	ENSG00000201102	.	27154	0.12
chr7_27957803_27957954	0.21	ENSG00000265382	.	37772	0.18
chr20_47448799_47448989	0.21	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	4474	0.31
chr6_1314742_1314893	0.20	FOXQ1	forkhead box Q1	2142	0.4
chr5_20109661_20109812	0.20	CDH18	cadherin 18, type 2	121397	0.07
chr14_89673001_89673195	0.20	FOXN3	forkhead box N3	26010	0.24
chr7_48675933_48676084	0.20	ABCA13	ATP-binding cassette, sub-family A (ABC1), member 13	128540	0.06
chr6_109414649_109415318	0.20	SESN1	sestrin 1	1039	0.42
chr5_64588165_64588316	0.20	ENSG00000207439	.	169044	0.03
chr2_102466743_102466894	0.20	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	5621	0.28
chr3_196697012_196697163	0.20	PIGZ	phosphatidylinositol glycan anchor biosynthesis, class Z	1345	0.35
chr6_27247805_27248026	0.20	POM121L2	POM121 transmembrane nucleoporin-like 2	31176	0.15
chr12_90287998_90288165	0.20	ENSG00000252823	.	140245	0.05
chr20_10399686_10399837	0.20	MKKS	McKusick-Kaufman syndrome	12809	0.19
chr2_113591900_113592051	0.19	IL1B	interleukin 1, beta	2036	0.29
chr15_43885389_43885540	0.19	CKMT1B	creatine kinase, mitochondrial 1B	170	0.9
chr3_129383548_129383699	0.19	TMCC1	transmembrane and coiled-coil domain family 1	8054	0.22
chr3_189515104_189515255	0.19	TP63	tumor protein p63	7589	0.27
chr1_150481112_150481644	0.19	ECM1	extracellular matrix protein 1	795	0.48
chr5_171389606_171389757	0.19	FBXW11	F-box and WD repeat domain containing 11	15079	0.25
chr3_87000039_87000329	0.19	VGLL3	vestigial like 3 (Drosophila)	39668	0.23
chr21_17959283_17959568	0.19	ENSG00000207863	.	3132	0.31
chr2_64878829_64879050	0.19	SERTAD2	SERTA domain containing 2	2108	0.38
chr12_50410240_50410391	0.18	RACGAP1	Rac GTPase activating protein 1	188	0.92
chr3_42864733_42864884	0.18	ACKR2	atypical chemokine receptor 2	3697	0.14
chr7_27211508_27211659	0.18	HOXA10	homeobox A10	2342	0.09
chr7_30326052_30326514	0.18	ZNRF2	zinc and ring finger 2	2360	0.29
chr2_192842795_192842946	0.18	AC098617.1		43768	0.2
chr3_132036252_132036528	0.18	ACPP	acid phosphatase, prostate	139	0.97
chr12_66198631_66198915	0.18	HMGA2	high mobility group AT-hook 2	19138	0.21
chr9_90133589_90133740	0.18	DAPK1	death-associated protein kinase 1	19744	0.23
chr2_172964285_172964474	0.18	DLX2	distal-less homeobox 2	3249	0.26
chr2_9348603_9349207	0.18	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	2011	0.46
chr9_90955493_90955644	0.18	ENSG00000252299	.	33616	0.2
chr17_57289227_57289378	0.18	SMG8	SMG8 nonsense mediated mRNA decay factor	518	0.64
chr17_56490979_56491130	0.18	RNF43	ring finger protein 43	1948	0.27
chr12_13332071_13332496	0.18	EMP1	epithelial membrane protein 1	17367	0.23
chr2_66803096_66803300	0.18	MEIS1	Meis homeobox 1	67139	0.13
chr14_94255244_94255403	0.18	PRIMA1	proline rich membrane anchor 1	496	0.86
chr6_86349087_86349642	0.18	SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	3345	0.23
chr12_104360447_104360701	0.18	TDG	thymine-DNA glycosylase	910	0.37
chr3_71478030_71478538	0.18	ENSG00000221264	.	112956	0.06
chr19_31830586_31830803	0.18	AC007796.1		9093	0.25
chr3_99619729_99619880	0.17	FILIP1L	filamin A interacting protein 1-like	24758	0.22
chr20_61555717_61555868	0.17	DIDO1	death inducer-obliterator 1	2029	0.26
chr11_67979557_67979856	0.17	SUV420H1	suppressor of variegation 4-20 homolog 1 (Drosophila)	515	0.8
chr10_108792061_108792212	0.17	ENSG00000200626	.	62357	0.16
chr15_90364678_90364977	0.17	ANPEP	alanyl (membrane) aminopeptidase	6194	0.14
chr8_70745749_70746362	0.17	RP11-159H10.3		291	0.62
chr6_99798162_99798313	0.17	FAXC	failed axon connections homolog (Drosophila)	706	0.71
chr2_145438866_145439017	0.17	ZEB2	zinc finger E-box binding homeobox 2	160320	0.04
chr4_71388674_71388825	0.17	AMTN	amelotin	4447	0.22
chr6_108886554_108887901	0.17	FOXO3	forkhead box O3	5158	0.32
chr16_87469465_87469755	0.17	ZCCHC14	zinc finger, CCHC domain containing 14	2870	0.22
chr11_47615339_47615925	0.17	C1QTNF4	C1q and tumor necrosis factor related protein 4	579	0.54
chr3_42135461_42135612	0.17	TRAK1	trafficking protein, kinesin binding 1	2974	0.36
chr12_51422377_51422723	0.17	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	201	0.91
chr1_28385256_28385469	0.17	EYA3	eyes absent homolog 3 (Drosophila)	764	0.61
chr7_22861355_22861506	0.17	TOMM7	translocase of outer mitochondrial membrane 7 homolog (yeast)	533	0.81
chr5_51742403_51742554	0.17	ITGA1	integrin, alpha 1	341252	0.01
chr18_24083261_24083412	0.17	KCTD1	potassium channel tetramerization domain containing 1	43627	0.17
chr10_118897625_118897901	0.17	VAX1	ventral anterior homeobox 1	49	0.97
chr9_13278507_13279169	0.17	RP11-272P10.2		348	0.67
chr12_48176505_48176789	0.17	AC004466.1	Uncharacterized protein	2059	0.24
chr15_98538729_98539013	0.17	ENSG00000252477	.	30400	0.18
chr6_65214990_65215141	0.17	RP11-349P19.1		127377	0.06
chr8_38857241_38857490	0.16	ADAM9	ADAM metallopeptidase domain 9	2860	0.19
chr8_117449236_117449387	0.16	ENSG00000264815	.	149723	0.04
chr1_157014914_157015379	0.16	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	16	0.98
chr6_37136440_37136591	0.16	PIM1	pim-1 oncogene	1464	0.41
chr3_112931196_112931871	0.16	BOC	BOC cell adhesion associated, oncogene regulated	124	0.97
chrX_73471805_73471956	0.16	ENSG00000265727	.	9144	0.12
chr1_214619591_214619742	0.16	PTPN14	protein tyrosine phosphatase, non-receptor type 14	18480	0.26
chr20_14317720_14318261	0.16	FLRT3	fibronectin leucine rich transmembrane protein 3	264	0.94
chr15_57373111_57373262	0.16	ENSG00000222586	.	114591	0.06
chr19_56166514_56167932	0.16	U2AF2	U2 small nuclear RNA auxiliary factor 2	792	0.34
chr3_119807952_119808228	0.16	GSK3B	glycogen synthase kinase 3 beta	4423	0.23
chr4_42153064_42153252	0.16	BEND4	BEN domain containing 4	1737	0.5
chr9_2160189_2160438	0.16	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	368	0.87
chr8_48572289_48573010	0.16	SPIDR	scaffolding protein involved in DNA repair	423	0.86
chr5_112762315_112762466	0.16	CTD-2201G3.1		6885	0.21
chr2_17009553_17009704	0.16	FAM49A	family with sequence similarity 49, member A	162029	0.04
chr2_198464213_198464591	0.15	RFTN2	raftlin family member 2	18217	0.19
chr15_43985226_43985377	0.15	CKMT1A	creatine kinase, mitochondrial 1A	203	0.87
chr13_78659821_78660303	0.15	RNF219-AS1	RNF219 antisense RNA 1	30772	0.24
chr3_171065824_171066073	0.15	ENSG00000222506	.	91367	0.09
chr19_11449502_11449733	0.15	RAB3D	RAB3D, member RAS oncogene family	727	0.43
chr17_26369297_26369946	0.15	NLK	nemo-like kinase	244	0.91
chr6_26184757_26184908	0.15	HIST1H2BE	histone cluster 1, H2be	874	0.29
chr4_164253130_164253399	0.15	NPY1R	neuropeptide Y receptor Y1	484	0.84
chr1_67398755_67399224	0.15	MIER1	mesoderm induction early response 1, transcriptional regulator	3063	0.27
chr8_48770878_48771029	0.15	ENSG00000211562	.	31666	0.17
chr20_4415632_4415783	0.15	ADRA1D	adrenoceptor alpha 1D	185986	0.03
chr2_186509945_186510096	0.15	ENSG00000212581	.	16481	0.26
chr1_34368788_34368939	0.15	RP5-1007G16.1		27796	0.2
chr5_130066537_130066688	0.15	ENSG00000252514	.	344239	0.01
chr14_65566001_65566152	0.15	MAX	MYC associated factor X	2981	0.21
chr20_44632803_44632954	0.15	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	4669	0.14
chr7_79767051_79767278	0.15	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	2093	0.45
chr1_86284190_86284341	0.15	ENSG00000201620	.	65216	0.13
chr14_35871775_35873043	0.15	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	937	0.68
chr2_27631132_27631707	0.15	PPM1G	protein phosphatase, Mg2+/Mn2+ dependent, 1G	1030	0.33
chrX_16825753_16826181	0.15	TXLNG	taxilin gamma	21412	0.16
chr15_39886218_39886369	0.15	CTD-2033D15.1		139	0.96
chr13_27975562_27975713	0.15	ENSG00000201242	.	1087	0.48
chr7_93999537_93999688	0.15	COL1A2	collagen, type I, alpha 2	24261	0.25
chr2_140023256_140023407	0.15	ENSG00000206901	.	245663	0.02
chr18_12315741_12315987	0.15	TUBB6	tubulin, beta 6 class V	4898	0.19
chr11_75210272_75210450	0.15	GDPD5	glycerophosphodiester phosphodiesterase domain containing 5	8565	0.15
chr3_168864469_168864620	0.15	MECOM	MDS1 and EVI1 complex locus	81	0.99
chr7_28724839_28725039	0.15	CREB5	cAMP responsive element binding protein 5	659	0.83
chr15_91204059_91204503	0.14	RP11-387D10.3		311	0.88
chr4_31024444_31024595	0.14	RP11-619J20.1		228927	0.02
chr6_145124672_145124823	0.14	UTRN	utrophin	4230	0.38
chr7_155090835_155091229	0.14	INSIG1	insulin induced gene 1	761	0.7
chr6_137532057_137532208	0.14	IFNGR1	interferon gamma receptor 1	7519	0.26
chr8_25070650_25071114	0.14	DOCK5	dedicator of cytokinesis 5	28502	0.2
chr1_183156151_183156302	0.14	LAMC2	laminin, gamma 2	803	0.7
chr10_77158203_77158354	0.14	ENSG00000237149	.	2999	0.24
chr17_26220981_26221377	0.14	LYRM9	LYR motif containing 9	770	0.4
chr10_97154342_97154493	0.14	SORBS1	sorbin and SH3 domain containing 1	21035	0.25
chr5_54605223_54605374	0.14	SKIV2L2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	1469	0.33
chr15_45933283_45933523	0.14	SQRDL	sulfide quinone reductase-like (yeast)	4676	0.21
chr1_159061696_159061989	0.14	AIM2	absent in melanoma 2	15151	0.17
chr2_60764234_60764468	0.14	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	16189	0.22
chr3_193852851_193853388	0.14	HES1	hes family bHLH transcription factor 1	815	0.62
chr4_143322143_143322556	0.14	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30063	0.27
chr15_67334158_67334332	0.14	SMAD3	SMAD family member 3	21856	0.25
chr20_57431129_57431280	0.14	GNAS	GNAS complex locus	971	0.45
chr11_130818088_130818239	0.14	SNX19	sorting nexin 19	31759	0.21
chr4_187491209_187491867	0.14	MTNR1A	melatonin receptor 1A	14817	0.17
chr2_190647319_190647470	0.14	ORMDL1	ORM1-like 1 (S. cerevisiae)	714	0.49
chr10_27815365_27815516	0.14	RAB18	RAB18, member RAS oncogene family	21892	0.24
chr15_59062577_59062767	0.14	FAM63B	family with sequence similarity 63, member B	841	0.54
chr4_124426780_124427488	0.14	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	106011	0.08
chr13_48796681_48797014	0.14	ITM2B	integral membrane protein 2B	10447	0.26
chr5_76527145_76527311	0.14	PDE8B	phosphodiesterase 8B	17459	0.23
chr1_174160405_174160556	0.14	ENSG00000238872	.	8888	0.23
chr1_231469833_231470794	0.14	SPRTN	SprT-like N-terminal domain	2537	0.25
chr13_21000022_21000173	0.14	ENSG00000263978	.	7888	0.27
chr2_238732566_238732717	0.14	RBM44	RNA binding motif protein 44	24820	0.17
chr2_144382037_144382188	0.14	AC092652.1		24342	0.17
chr6_21597329_21597632	0.14	SOX4	SRY (sex determining region Y)-box 4	3409	0.4
chr1_215742028_215742345	0.14	KCTD3	potassium channel tetramerization domain containing 3	1451	0.56
chr11_737225_737376	0.14	TALDO1	transaldolase 1	10029	0.07
chr2_217859430_217859581	0.14	AC007563.1		120850	0.05
chr1_151963774_151963995	0.14	S100A10	S100 calcium binding protein A10	1170	0.39
chr8_12989527_12990464	0.14	DLC1	deleted in liver cancer 1	988	0.62
chr1_109583292_109583606	0.14	WDR47	WD repeat domain 47	720	0.6
chr1_161703743_161703894	0.14	ENSG00000241347	.	1780	0.22
chr15_38558851_38559240	0.14	SPRED1	sprouty-related, EVH1 domain containing 1	13663	0.3
chr2_175202799_175202950	0.14	AC018470.1	Uncharacterized protein FLJ46347	723	0.62
chr12_29434762_29434913	0.13	RP11-996F15.2		35944	0.16
chr8_66752673_66753180	0.13	PDE7A	phosphodiesterase 7A	817	0.75
chr9_140524792_140524954	0.13	EHMT1	euchromatic histone-lysine N-methyltransferase 1	11419	0.13
chr5_14036124_14036305	0.13	DNAH5	dynein, axonemal, heavy chain 5	91562	0.09
chr8_98928953_98929409	0.13	MATN2	matrilin 2	14388	0.23
chr9_17136040_17136191	0.13	CNTLN	centlein, centrosomal protein	1077	0.67
chr8_71359268_71359419	0.13	ENSG00000253143	.	33379	0.17
chr16_75033273_75033750	0.13	ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	268	0.92
chr6_122719971_122720474	0.13	HSF2	heat shock transcription factor 2	469	0.87
chr7_74074778_74074955	0.13	GTF2I	general transcription factor IIi	2509	0.33
chr20_45982305_45982568	0.13	RP4-569M23.2		1131	0.31
chr4_159417737_159417888	0.13	RP11-781M16.2		13248	0.22
chr16_19769260_19769411	0.13	CTD-2380F24.1		8031	0.18
chr1_43151006_43151188	0.13	YBX1	Y box binding protein 1	2439	0.25
chr5_39412000_39412151	0.13	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	12895	0.26

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.2	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.2	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.1	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.2	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.2	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.2	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.3	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.0	0.1	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.2	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0070391	response to lipoteichoic acid(GO:0070391) cellular response to lipoteichoic acid(GO:0071223)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0043552	regulation of phosphatidylinositol 3-kinase activity(GO:0043551) positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.2	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0042135	neurotransmitter catabolic process(GO:0042135)
0.0	0.0	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.2	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.2	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.0	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0021903	rostrocaudal neural tube patterning(GO:0021903)
0.0	0.1	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0060573	ventral spinal cord interneuron differentiation(GO:0021514) ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.0	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0045008	depyrimidination(GO:0045008)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0098930	axonal transport(GO:0098930)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:0045986	negative regulation of smooth muscle contraction(GO:0045986)
0.0	0.1	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.0	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.0	GO:0048263	determination of dorsal identity(GO:0048263)
0.0	0.0	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.0	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.0	GO:0033504	floor plate development(GO:0033504)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.3	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.1	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.0	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.2	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0006907	pinocytosis(GO:0006907)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0042573	retinoic acid metabolic process(GO:0042573)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.3	GO:0019079	viral genome replication(GO:0019079)
0.0	0.0	GO:0090224	regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0	0.0	GO:0010544	negative regulation of platelet activation(GO:0010544)
0.0	0.3	GO:0048146	positive regulation of fibroblast proliferation(GO:0048146)
0.0	0.1	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.2	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2	GO:0002102	podosome(GO:0002102)
0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	GO:0001652	granular component(GO:0001652)
0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.1	GO:0031045	dense core granule(GO:0031045)
0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.4	GO:0045178	basal part of cell(GO:0045178)
0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	GO:0032059	bleb(GO:0032059)
0.1	GO:0000109	nucleotide-excision repair complex(GO:0000109)
0.4	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	GO:0005588	collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.2	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.2	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.2	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.3	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.0	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.2	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0043236	laminin binding(GO:0043236)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)
0.0	0.0	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.0	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.0	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.2	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME GABA B RECEPTOR ACTIVATION	Genes involved in GABA B receptor activation