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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for IRF3

Z-value: 2.56

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Transcription factors associated with IRF3

Gene Symbol	Gene ID	Gene Info
IRF3 Ensembl NCBI GeneCards UniProt	ENSG00000126456.11	interferon regulatory factor 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr19_50167405_50167698	IRF3	544	0.467635	0.65	5.9e-02	Click!
chr19_50168307_50168780	IRF3	55	0.749989	0.52	1.5e-01	Click!
chr19_50167969_50168187	IRF3	17	0.899033	0.50	1.7e-01	Click!
chr19_50168782_50169140	IRF3	1	0.595613	0.07	8.5e-01	Click!

Activity of the IRF3 motif across conditions

Conditions sorted by the z-value of the IRF3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_2960178_2960440	2.70	RP11-737O24.1		6707	0.16
chr12_51716816_51717143	2.50	BIN2	bridging integrator 2	920	0.52
chr16_4115246_4115423	2.48	RP11-462G12.4		33321	0.16
chr7_37382144_37382404	2.19	ELMO1	engulfment and cell motility 1	93	0.97
chr3_172240144_172241280	2.08	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	553	0.83
chr1_151129106_151129618	2.07	SCNM1	sodium channel modifier 1	222	0.51
chr1_84556504_84556817	1.91	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	12833	0.27
chr12_113415975_113416207	1.91	OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	109	0.96
chr5_131800027_131800603	1.86	ENSG00000202533	.	3524	0.16
chr2_201238626_201239302	1.85	ENSG00000201649	.	1066	0.5
chr6_135545194_135545568	1.84	ENSG00000207689	.	14917	0.16
chr3_36949362_36950295	1.84	TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	36720	0.16
chr2_97439727_97440064	1.79	CNNM4	cyclin M4	13256	0.14
chr8_29356447_29357119	1.76	RP4-676L2.1		146096	0.04
chr21_19161404_19161758	1.71	AL109761.5		4224	0.27
chr4_75263884_75264078	1.69	EREG	epiregulin	33121	0.14
chr19_17516551_17516849	1.66	MVB12A	multivesicular body subunit 12A	150	0.6
chr17_43487096_43487739	1.63	ARHGAP27	Rho GTPase activating protein 27	335	0.82
chr11_104904746_104905919	1.62	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chr2_241630055_241630353	1.61	AQP12A	aquaporin 12A	1058	0.43
chr6_163881136_163881820	1.60	QKI	QKI, KH domain containing, RNA binding	5115	0.35
chr18_23770689_23770840	1.60	TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	35136	0.17
chr7_7298568_7298818	1.60	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	24742	0.22
chr19_38539731_38539968	1.60	ENSG00000221258	.	4756	0.2
chr2_136447378_136447607	1.58	R3HDM1	R3H domain containing 1	14524	0.17
chr14_91488738_91489174	1.56	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	37522	0.15
chr10_15250983_15251323	1.53	RP11-25G10.2		28338	0.18
chr8_142255255_142255924	1.51	RP11-10J21.4		7802	0.15
chr17_17531992_17532217	1.51	PEMT	phosphatidylethanolamine N-methyltransferase	37082	0.12
chr13_49832065_49832609	1.49	CDADC1	cytidine and dCMP deaminase domain containing 1	10153	0.23
chr7_30766967_30767188	1.48	INMT	indolethylamine N-methyltransferase	24674	0.16
chr10_70444201_70444500	1.48	RP11-119F7.5		13907	0.15
chr11_108095871_108096022	1.47	ATM	ataxia telangiectasia mutated	1141	0.41
chr10_77531854_77532472	1.43	C10orf11	chromosome 10 open reading frame 11	10356	0.22
chr8_22875866_22876082	1.43	RP11-875O11.1		874	0.48
chr6_14755159_14755442	1.42	ENSG00000206960	.	108534	0.08
chr13_40532608_40532878	1.42	ENSG00000212553	.	101379	0.08
chr12_40077019_40077550	1.37	C12orf40	chromosome 12 open reading frame 40	57299	0.13
chr6_130459797_130459948	1.37	RP11-73O6.3		531	0.83
chr10_11212951_11213685	1.36	RP3-323N1.2		21	0.98
chr14_22984074_22984225	1.35	TRAJ15	T cell receptor alpha joining 15	14431	0.1
chr14_81940547_81940744	1.34	STON2	stonin 2	37836	0.2
chr21_36399790_36399994	1.33	RUNX1	runt-related transcription factor 1	21570	0.29
chrX_25086022_25086209	1.33	ENSG00000240439	.	7059	0.28
chr2_202766440_202766591	1.31	ENSG00000212184	.	25647	0.16
chr1_66801255_66801864	1.30	PDE4B	phosphodiesterase 4B, cAMP-specific	3687	0.36
chr1_167599991_167600483	1.29	RP3-455J7.4		326	0.69
chr20_45623189_45623371	1.29	EYA2	eyes absent homolog 2 (Drosophila)	4640	0.32
chr5_148188804_148189074	1.29	ADRB2	adrenoceptor beta 2, surface	17217	0.25
chr14_89895919_89896980	1.28	FOXN3-AS1	FOXN3 antisense RNA 1	12751	0.17
chr9_112910661_112911343	1.27	AKAP2	A kinase (PRKA) anchor protein 2	23221	0.22
chr11_60214184_60214345	1.27	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	8961	0.16
chr1_121200380_121200843	1.27	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	264674	0.02
chr14_93570056_93570236	1.26	ITPK1	inositol-tetrakisphosphate 1-kinase	11471	0.19
chr4_89377941_89378199	1.26	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	198	0.94
chr3_69140694_69141185	1.25	ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	6767	0.15
chr16_23837804_23837955	1.24	PRKCB	protein kinase C, beta	9443	0.23
chr3_176919226_176919959	1.23	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	4331	0.31
chr2_10930843_10930994	1.23	PDIA6	protein disulfide isomerase family A, member 6	21962	0.15
chr3_172241325_172241476	1.23	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	103	0.98
chr6_166955535_166955806	1.23	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	268	0.92
chr12_90693017_90693168	1.21	ENSG00000252823	.	545256	0.0
chr19_11546030_11546251	1.21	PRKCSH	protein kinase C substrate 80K-H	31	0.69
chr1_89664351_89664632	1.21	GBP4	guanylate binding protein 4	124	0.96
chr20_35575234_35575857	1.19	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr1_42995299_42995540	1.18	CCDC30	coiled-coil domain containing 30	5141	0.22
chr4_154390309_154390666	1.17	KIAA0922	KIAA0922	2986	0.33
chr1_67235326_67235808	1.17	TCTEX1D1	Tctex1 domain containing 1	17424	0.16
chr18_60173458_60173677	1.16	ZCCHC2	zinc finger, CCHC domain containing 2	16673	0.25
chr6_109836914_109837233	1.16	AK9	adenylate kinase 9	9452	0.14
chr2_235401709_235401860	1.16	ARL4C	ADP-ribosylation factor-like 4C	3460	0.39
chr22_40858602_40858925	1.14	MKL1	megakaryoblastic leukemia (translocation) 1	659	0.7
chr10_12408131_12408282	1.14	CAMK1D	calcium/calmodulin-dependent protein kinase ID	16474	0.18
chr2_143887292_143887566	1.13	ARHGAP15	Rho GTPase activating protein 15	546	0.84
chr1_212360004_212360155	1.12	ENSG00000252879	.	87061	0.07
chr22_46828258_46828832	1.10	TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	96726	0.06
chr20_218609_218760	1.10	DEFB129	defensin, beta 129	10785	0.14
chr6_88355044_88355273	1.10	ORC3	origin recognition complex, subunit 3	5490	0.23
chr6_20207196_20207478	1.09	RP11-239H6.2		4981	0.25
chrX_21992254_21992490	1.09	SMS	spermine synthase	33209	0.17
chr9_132652742_132652893	1.09	FNBP1	formin binding protein 1	28772	0.13
chr1_27998753_27999101	1.08	IFI6	interferon, alpha-inducible protein 6	198	0.89
chr16_53552293_53552836	1.08	AKTIP	AKT interacting protein	14241	0.21
chr6_149802896_149803566	1.08	ZC3H12D	zinc finger CCCH-type containing 12D	1038	0.49
chr17_66234126_66234354	1.08	AMZ2	archaelysin family metallopeptidase 2	9475	0.16
chr4_169239932_169240110	1.07	DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	63	0.98
chrX_15800485_15800703	1.07	ZRSR2	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2	8001	0.2
chr12_92525894_92526627	1.07	C12orf79	chromosome 12 open reading frame 79	4537	0.2
chr10_3514525_3515428	1.07	RP11-184A2.3		278283	0.01
chr15_64888931_64889431	1.06	ENSG00000207223	.	55906	0.09
chr3_121151020_121151375	1.06	POLQ	polymerase (DNA directed), theta	113656	0.06
chr5_133465026_133465422	1.06	TCF7	transcription factor 7 (T-cell specific, HMG-box)	5915	0.23
chr2_198670742_198670893	1.06	PLCL1	phospholipase C-like 1	1391	0.48
chr18_20156538_20156689	1.05	ENSG00000206827	.	70932	0.12
chr17_4618141_4618477	1.04	ARRB2	arrestin, beta 2	575	0.53
chr1_235500116_235500688	1.03	GGPS1	geranylgeranyl diphosphate synthase 1	8058	0.18
chr2_226329396_226329663	1.03	NYAP2	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	55932	0.18
chr14_71338943_71339141	1.03	PCNX	pecanex homolog (Drosophila)	35080	0.2
chr2_225822345_225822719	1.02	DOCK10	dedicator of cytokinesis 10	10750	0.28
chr19_7412287_7412438	1.02	CTB-133G6.1		1486	0.35
chrX_57313067_57313960	1.02	FAAH2	fatty acid amide hydrolase 2	374	0.92
chrX_41190531_41191099	1.02	DDX3X	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	1836	0.31
chr4_111437444_111437685	1.02	RP11-380D23.1		3097	0.31
chr6_159430195_159430346	1.02	RSPH3	radial spoke 3 homolog (Chlamydomonas)	9051	0.18
chr6_17702300_17702488	1.01	RP11-500C11.3		4094	0.18
chr1_45516840_45517014	1.01	ENSG00000264650	.	17235	0.16
chr1_212112149_212112479	1.01	ENSG00000212187	.	86589	0.07
chr5_37111972_37112156	1.01	NIPBL	Nipped-B homolog (Drosophila)	53059	0.15
chr11_67417906_67418392	1.01	ACY3	aspartoacylase (aminocyclase) 3	19	0.96
chr6_31540117_31540270	1.01	LTA	lymphotoxin alpha	133	0.85
chr8_10981623_10981799	0.99	AF131215.3		1863	0.24
chr6_25034643_25035296	0.99	ENSG00000244618	.	3459	0.22
chr4_73951905_73952308	0.99	COX18	COX18 cytochrome C oxidase assembly factor	16648	0.24
chr1_207263069_207263220	0.98	C4BPB	complement component 4 binding protein, beta	257	0.89
chr13_46749618_46749812	0.98	ENSG00000240767	.	5832	0.17
chrY_15016828_15017148	0.98	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	246	0.96
chr11_128382477_128382951	0.98	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	7425	0.24
chr2_38981773_38982016	0.98	GEMIN6	gem (nuclear organelle) associated protein 6	3218	0.21
chr5_98362961_98363596	0.97	ENSG00000200351	.	90827	0.09
chr5_32583768_32584065	0.97	SUB1	SUB1 homolog (S. cerevisiae)	1689	0.49
chr10_26109879_26110030	0.97	ENSG00000251711	.	1599	0.44
chr9_126101480_126101665	0.97	CRB2	crumbs homolog 2 (Drosophila)	16877	0.22
chr8_100511479_100511630	0.97	VPS13B	vacuolar protein sorting 13 homolog B (yeast)	21573	0.16
chr11_63304045_63305245	0.96	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	352	0.84
chr4_154354394_154354673	0.96	KIAA0922	KIAA0922	32965	0.17
chr5_142814700_142814933	0.96	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	261	0.95
chr2_231090336_231091061	0.95	SP140	SP140 nuclear body protein	219	0.54
chr10_91061669_91062419	0.95	IFIT2	interferon-induced protein with tetratricopeptide repeats 2	332	0.85
chr7_102066904_102067285	0.95	ORAI2	ORAI calcium release-activated calcium modulator 2	6459	0.09
chr6_28108040_28108408	0.95	ZKSCAN8	zinc finger with KRAB and SCAN domains 8	1492	0.26
chr6_119397609_119397881	0.95	FAM184A	family with sequence similarity 184, member A	1792	0.35
chr14_22987545_22987798	0.95	TRAJ15	T cell receptor alpha joining 15	10909	0.1
chr16_28200140_28200315	0.95	ENSG00000200138	.	5588	0.18
chr6_136547532_136547683	0.94	RP13-143G15.4		874	0.62
chr14_38558504_38558837	0.94	CTD-2058B24.2		1693	0.48
chr13_41558712_41559488	0.94	ELF1	E74-like factor 1 (ets domain transcription factor)	2682	0.29
chr14_99710276_99710624	0.94	AL109767.1		18835	0.2
chr14_52688265_52688453	0.94	PTGDR	prostaglandin D2 receptor (DP)	46072	0.17
chr6_106546757_106547354	0.94	PRDM1	PR domain containing 1, with ZNF domain	240	0.87
chr11_65695547_65695843	0.93	DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	8500	0.09
chr18_61875105_61875312	0.93	SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	228166	0.02
chr4_99560865_99561052	0.93	TSPAN5	tetraspanin 5	17828	0.22
chr16_68771805_68771956	0.93	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	625	0.67
chr8_124049779_124050367	0.93	TBC1D31	TBC1 domain family, member 31	4135	0.17
chr4_38320095_38320594	0.93	ENSG00000221495	.	80110	0.11
chr17_78237440_78238417	0.92	RNF213	ring finger protein 213	3259	0.2
chr3_151996699_151997067	0.92	MBNL1-AS1	MBNL1 antisense RNA 1	9539	0.22
chr15_31765211_31765362	0.92	KLF13	Kruppel-like factor 13	106929	0.07
chr2_242050726_242051223	0.91	MTERFD2	MTERF domain containing 2	9227	0.14
chr11_82873492_82873814	0.91	PCF11	PCF11 cleavage and polyadenylation factor subunit	5452	0.18
chr16_68503734_68504345	0.90	ENSG00000199263	.	4528	0.18
chr20_34356216_34356461	0.90	ENSG00000222152	.	1451	0.3
chr7_113688461_113688709	0.89	PPP1R3A	protein phosphatase 1, regulatory subunit 3A	27390	0.22
chr4_154354700_154355154	0.89	KIAA0922	KIAA0922	32571	0.17
chr12_121829638_121829987	0.89	ANAPC5	anaphase promoting complex subunit 5	7887	0.2
chr18_9120826_9120977	0.89	RP11-143J12.3		5026	0.17
chr17_29835728_29836211	0.89	ENSG00000264862	.	9481	0.13
chr12_64852912_64853865	0.89	TBK1	TANK-binding kinase 1	7133	0.2
chr3_149419430_149419681	0.89	WWTR1	WW domain containing transcription regulator 1	1505	0.39
chrX_11782139_11782290	0.89	MSL3	male-specific lethal 3 homolog (Drosophila)	4467	0.34
chr17_40424757_40425084	0.88	AC003104.1		219	0.88
chr1_8455637_8455851	0.88	RERE	arginine-glutamic acid dipeptide (RE) repeats	27982	0.15
chr8_130984307_130984565	0.87	FAM49B	family with sequence similarity 49, member B	1200	0.49
chr3_16343777_16343928	0.87	RP11-415F23.2		12094	0.16
chr10_6092659_6092973	0.87	IL2RA	interleukin 2 receptor, alpha	11437	0.14
chr1_7997092_7997243	0.87	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	2007	0.31
chr3_3214293_3214763	0.87	CRBN	cereblon	6830	0.19
chr17_76768494_76768645	0.86	CYTH1	cytohesin 1	9785	0.19
chr1_7999776_7999927	0.86	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	1075	0.5
chr19_42027879_42028178	0.86	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	27858	0.13
chr8_32725973_32726498	0.85	ENSG00000212407	.	42881	0.21
chr3_153005612_153005763	0.85	ENSG00000265813	.	87881	0.09
chrX_80376808_80377206	0.85	HMGN5	high mobility group nucleosome binding domain 5	130	0.98
chr11_128563440_128563664	0.85	FLI1	Fli-1 proto-oncogene, ETS transcription factor	113	0.96
chr14_61857715_61857866	0.85	PRKCH	protein kinase C, eta	378	0.9
chr18_52613562_52613787	0.85	CCDC68	coiled-coil domain containing 68	9538	0.22
chr7_92347129_92347835	0.85	ENSG00000206763	.	16354	0.24
chr7_92777462_92777762	0.85	SAMD9L	sterile alpha motif domain containing 9-like	46	0.98
chr13_76341018_76341169	0.85	LMO7	LIM domain 7	6296	0.28
chr1_111329563_111329714	0.84	ENSG00000199710	.	22510	0.19
chr17_71548139_71548468	0.84	RP11-449L23.3		32318	0.17
chr7_142196971_142197122	0.84	MTRNR2L6	MT-RNR2-like 6	177058	0.03
chr17_17863409_17863570	0.84	TOM1L2	target of myb1-like 2 (chicken)	12222	0.15
chr6_25367391_25367687	0.83	ENSG00000207490	.	16288	0.18
chr1_212360214_212360441	0.83	ENSG00000252879	.	87309	0.07
chr11_122940653_122941208	0.82	HSPA8	heat shock 70kDa protein 8	6992	0.15
chr12_66311785_66312262	0.82	AC090673.2	Uncharacterized protein	5944	0.2
chr17_33570667_33570848	0.82	SLFN5	schlafen family member 5	649	0.46
chr5_43039425_43040424	0.82	AC025171.1		1753	0.28
chr16_81037806_81038351	0.82	CENPN	centromere protein N	2025	0.2
chr12_2800154_2801438	0.81	CACNA1C-AS1	CACNA1C antisense RNA 1	430	0.83
chr6_26440749_26441260	0.81	BTN3A3	butyrophilin, subfamily 3, member A3	218	0.89
chr10_35416363_35416802	0.81	CREM	cAMP responsive element modulator	177	0.83
chr13_50727258_50727409	0.81	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	71026	0.1
chr14_22538566_22539116	0.81	ENSG00000238634	.	72046	0.12
chr20_44509550_44509701	0.80	ZSWIM1	zinc finger, SWIM-type containing 1	241	0.82
chr5_36071274_36071728	0.80	UGT3A2	UDP glycosyltransferase 3 family, polypeptide A2	4115	0.23
chr15_65187803_65188133	0.80	ENSG00000264929	.	4470	0.17
chr5_128461724_128461875	0.80	ENSG00000264563	.	28418	0.21
chr7_90092750_90092909	0.80	CDK14	cyclin-dependent kinase 14	2909	0.32

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.3	0.9	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.3	0.9	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3	0.8	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.3	0.8	GO:0035455	response to interferon-alpha(GO:0035455)
0.3	0.8	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.2	1.2	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.2	0.9	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.2	2.2	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.2	0.6	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.2	0.5	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.2	0.4	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.2	0.5	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.2	0.6	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1	0.6	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	0.6	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1	1.1	GO:0051900	regulation of mitochondrial depolarization(GO:0051900)
0.1	0.4	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.1	0.6	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.5	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.1	0.5	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.1	0.2	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.1	0.5	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1	0.3	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.3	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	2.7	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.1	0.4	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.1	0.4	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.1	0.5	GO:0070670	response to interleukin-4(GO:0070670)
0.1	0.1	GO:0001562	response to protozoan(GO:0001562)
0.1	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.3	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.1	0.2	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1	0.9	GO:0032607	interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727)
0.1	0.2	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.5	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1	0.9	GO:0006379	mRNA cleavage(GO:0006379)
0.1	0.5	GO:0016584	nucleosome positioning(GO:0016584)
0.1	0.2	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.1	0.2	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.6	GO:0015671	oxygen transport(GO:0015671)
0.1	2.0	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.3	GO:0017085	response to insecticide(GO:0017085)
0.1	0.2	GO:0006089	lactate metabolic process(GO:0006089)
0.1	0.2	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.1	0.4	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1	0.4	GO:0018345	protein palmitoylation(GO:0018345)
0.1	0.3	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1	0.3	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.1	0.4	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.2	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.1	1.0	GO:0001893	maternal placenta development(GO:0001893)
0.1	0.2	GO:0070141	response to UV-A(GO:0070141)
0.1	1.6	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.1	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1	0.2	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.1	0.2	GO:0008215	spermine metabolic process(GO:0008215)
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.3	GO:0060539	diaphragm development(GO:0060539)
0.1	0.5	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.1	0.2	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.1	0.3	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1	0.4	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.1	0.2	GO:0016572	histone phosphorylation(GO:0016572)
0.1	3.5	GO:0034340	response to type I interferon(GO:0034340)
0.1	0.3	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	0.9	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.1	0.2	GO:0019985	translesion synthesis(GO:0019985)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.1	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.1	0.2	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.1	0.4	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.5	GO:0032456	endocytic recycling(GO:0032456)
0.1	0.1	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.1	0.2	GO:0034629	cellular protein complex localization(GO:0034629)
0.1	0.2	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.1	0.4	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1	0.9	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.1	0.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	0.9	GO:0042130	negative regulation of T cell proliferation(GO:0042130)
0.0	0.0	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.2	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.2	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.2	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.4	GO:0000090	mitotic anaphase(GO:0000090)
0.0	0.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.5	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.4	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0071028	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.5	GO:0001706	endoderm formation(GO:0001706)
0.0	0.0	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.3	GO:0050746	regulation of lipoprotein metabolic process(GO:0050746)
0.0	0.2	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.2	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.2	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.2	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.2	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.2	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.3	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:1901222	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.3	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.4	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.2	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.3	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.7	GO:0000722	telomere maintenance via recombination(GO:0000722)
0.0	0.1	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	1.2	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.3	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:0070100	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827) Roundabout signaling pathway(GO:0035385) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.2	GO:0018065	protein-cofactor linkage(GO:0018065)
0.0	0.1	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.1	GO:0060968	regulation of gene silencing(GO:0060968)
0.0	0.1	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb(GO:0022028)
0.0	0.2	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.3	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.3	GO:0048103	somatic stem cell division(GO:0048103)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.2	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.3	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.2	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.2	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.1	GO:0051798	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.9	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	0.3	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.0	0.5	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.3	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.2	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.4	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.6	GO:0045598	regulation of fat cell differentiation(GO:0045598)
0.0	0.1	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.8	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:1901796	regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) regulation of signal transduction by p53 class mediator(GO:1901796)
0.0	0.2	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812) negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0017145	stem cell division(GO:0017145)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0040019	positive regulation of embryonic development(GO:0040019)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.3	GO:0046632	alpha-beta T cell differentiation(GO:0046632)
0.0	0.1	GO:0043496	regulation of protein homodimerization activity(GO:0043496)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.2	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.2	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.5	GO:0043486	histone exchange(GO:0043486)
0.0	0.0	GO:0032469	endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.4	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.2	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.2	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.0	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.1	GO:0045824	negative regulation of innate immune response(GO:0045824)
0.0	0.3	GO:0006195	purine nucleotide catabolic process(GO:0006195)
0.0	0.1	GO:0015669	gas transport(GO:0015669)
0.0	4.6	GO:0045087	innate immune response(GO:0045087)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.4	GO:0001569	patterning of blood vessels(GO:0001569)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0051974	negative regulation of telomerase activity(GO:0051974)
0.0	0.0	GO:0052031	modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0	0.3	GO:0008272	sulfate transport(GO:0008272)
0.0	0.3	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.4	GO:0043488	regulation of mRNA stability(GO:0043488)
0.0	0.1	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.2	GO:0006929	substrate-dependent cell migration(GO:0006929)
0.0	0.5	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.5	GO:0006959	humoral immune response(GO:0006959)
0.0	0.0	GO:0045986	negative regulation of smooth muscle contraction(GO:0045986)
0.0	0.1	GO:0018410	C-terminal protein amino acid modification(GO:0018410)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0010823	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	1.1	GO:0000216	obsolete M/G1 transition of mitotic cell cycle(GO:0000216)
0.0	0.1	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0033015	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	1.1	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0	0.1	GO:0046036	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0	0.1	GO:0030157	pancreatic juice secretion(GO:0030157)
0.0	0.1	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0030573	bile acid catabolic process(GO:0030573)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.4	GO:0032006	regulation of TOR signaling(GO:0032006)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.5	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	0.0	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.0	GO:0032230	positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0	0.1	GO:0042438	melanin biosynthetic process(GO:0042438)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0060456	positive regulation of digestive system process(GO:0060456)
0.0	0.0	GO:0000255	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.4	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.0	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.3	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:1902579	multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.2	GO:0030890	positive regulation of B cell proliferation(GO:0030890)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.7	GO:0006200	obsolete ATP catabolic process(GO:0006200)
0.0	0.1	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.0	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0010979	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.0	GO:0001773	myeloid dendritic cell activation(GO:0001773)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.4	GO:0042594	response to starvation(GO:0042594)
0.0	0.1	GO:0006984	ER-nucleus signaling pathway(GO:0006984)
0.0	0.1	GO:0000087	mitotic M phase(GO:0000087)
0.0	1.5	GO:0006333	chromatin assembly or disassembly(GO:0006333)
0.0	0.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.0	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.7	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.0	0.1	GO:0033683	nucleotide-excision repair, DNA incision(GO:0033683)
0.0	0.1	GO:0045768	obsolete positive regulation of anti-apoptosis(GO:0045768)
0.0	0.0	GO:0044406	virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650) receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0044783	mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) mitotic G1/S transition checkpoint(GO:0044819)
0.0	0.0	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.0	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.0	0.1	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin(GO:0001991)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.1	GO:0007625	grooming behavior(GO:0007625)
0.0	0.2	GO:0006997	nucleus organization(GO:0006997)
0.0	0.6	GO:0000236	mitotic prometaphase(GO:0000236)
0.0	0.1	GO:0042129	regulation of T cell proliferation(GO:0042129)
0.0	0.6	GO:0019221	cytokine-mediated signaling pathway(GO:0019221)
0.0	1.0	GO:0051028	mRNA transport(GO:0051028)
0.0	0.0	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.1	GO:0030071	regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.2	GO:0070206	protein trimerization(GO:0070206)
0.0	0.1	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.0	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.0	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.0	GO:0050913	sensory perception of bitter taste(GO:0050913)
0.0	0.0	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.0	GO:0044773	mitotic DNA damage checkpoint(GO:0044773)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.0	GO:0070474	uterine smooth muscle contraction(GO:0070471) regulation of uterine smooth muscle contraction(GO:0070472) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.0	0.1	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.1	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0031017	exocrine pancreas development(GO:0031017)
0.0	0.0	GO:0032099	negative regulation of appetite(GO:0032099)
0.0	0.4	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.0	0.0	GO:0045188	circadian sleep/wake cycle, non-REM sleep(GO:0042748) regulation of circadian sleep/wake cycle, non-REM sleep(GO:0045188) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.1	GO:0051318	G1 phase(GO:0051318)
0.0	0.0	GO:0090075	relaxation of muscle(GO:0090075)
0.0	0.3	GO:0006446	regulation of translational initiation(GO:0006446)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0035094	response to nicotine(GO:0035094)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0051444	negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.0	0.0	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.0	GO:0030091	protein repair(GO:0030091)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.4	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.5	GO:0042825	TAP complex(GO:0042825)
0.1	0.6	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	0.8	GO:0030677	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.1	0.3	GO:0072487	MSL complex(GO:0072487)
0.1	0.7	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.7	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	0.4	GO:0016589	NURF complex(GO:0016589)
0.1	0.7	GO:0008180	COP9 signalosome(GO:0008180)
0.1	0.3	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	0.2	GO:0001652	granular component(GO:0001652)
0.1	0.4	GO:0005663	DNA replication factor C complex(GO:0005663)
0.1	0.5	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.8	GO:0016235	aggresome(GO:0016235)
0.1	1.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.1	0.2	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	0.1	GO:0000805	X chromosome(GO:0000805) Barr body(GO:0001740)
0.1	1.0	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.1	0.2	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.1	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	0.4	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.4	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.6	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.4	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.4	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.2	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.8	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.4	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.4	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.3	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.2	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.3	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.5	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.2	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.2	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	1.1	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.2	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0090568	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.7	GO:0031526	brush border membrane(GO:0031526)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.7	GO:0042645	mitochondrial nucleoid(GO:0042645)
0.0	0.3	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.2	GO:0043256	laminin complex(GO:0043256)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.3	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.6	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.6	GO:0000781	chromosome, telomeric region(GO:0000781)
0.0	0.0	GO:0032059	bleb(GO:0032059)
0.0	3.4	GO:0000785	chromatin(GO:0000785)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.1	GO:0031306	intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	1.6	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.3	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	1.1	GO:0031985	Golgi cisterna(GO:0031985)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0005682	U5 snRNP(GO:0005682)
0.0	1.4	GO:0016607	nuclear speck(GO:0016607)
0.0	0.0	GO:0043230	extracellular organelle(GO:0043230)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.6	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.3	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	1.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	1.3	GO:0098687	chromosomal region(GO:0098687)
0.0	0.1	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0	0.2	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.5	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0043204	perikaryon(GO:0043204)
0.0	0.3	GO:0043195	terminal bouton(GO:0043195)
0.0	0.1	GO:0031672	A band(GO:0031672)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.8	GO:0005746	mitochondrial respiratory chain(GO:0005746)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.5	GO:0015030	Cajal body(GO:0015030)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	2.5	GO:0010008	endosome membrane(GO:0010008)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.0	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.0	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0	0.0	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.0	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.0	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.3	GO:0016363	nuclear matrix(GO:0016363)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.2	0.6	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.2	1.0	GO:0004046	aminoacylase activity(GO:0004046)
0.2	0.5	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.2	0.5	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.2	0.7	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.2	0.7	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.2	1.2	GO:0031701	angiotensin receptor binding(GO:0031701)
0.1	0.4	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.1	0.9	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.5	GO:0046977	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.1	0.9	GO:0050700	CARD domain binding(GO:0050700)
0.1	0.6	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1	0.5	GO:0031404	chloride ion binding(GO:0031404)
0.1	1.9	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1	0.4	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.4	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1	0.9	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1	0.3	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.4	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1	0.8	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.3	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1	0.6	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.1	1.1	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.5	GO:0031491	nucleosome binding(GO:0031491)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.6	GO:0005522	profilin binding(GO:0005522)
0.1	0.8	GO:0004526	ribonuclease P activity(GO:0004526)
0.1	0.6	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.1	0.2	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.3	GO:0030911	TPR domain binding(GO:0030911)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.4	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	0.4	GO:0070513	death domain binding(GO:0070513)
0.1	0.3	GO:0032407	MutSalpha complex binding(GO:0032407)
0.1	0.2	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	0.3	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.1	0.6	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.1	0.2	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.1	0.4	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.1	0.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.2	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.1	0.3	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	0.5	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	0.3	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.1	0.3	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.1	0.3	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	0.4	GO:0030507	spectrin binding(GO:0030507)
0.1	0.2	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.1	0.2	GO:0036002	pre-mRNA binding(GO:0036002)
0.1	0.2	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	0.3	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	0.2	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.4	GO:0019864	IgG binding(GO:0019864)
0.0	0.5	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.5	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.7	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.8	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.2	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	4.5	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.2	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.3	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.4	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.2	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.2	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.5	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.2	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.2	GO:0051998	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.2	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	3.7	GO:0008026	ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0	2.1	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.5	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.2	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.2	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.2	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.6	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.2	GO:0005497	androgen binding(GO:0005497)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.7	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.8	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.3	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.3	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.8	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.3	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	1.1	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	0.9	GO:0004386	helicase activity(GO:0004386)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.6	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.8	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.3	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.8	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.3	GO:0019213	deacetylase activity(GO:0019213)
0.0	0.5	GO:1990782	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.2	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	2.0	GO:0003704	obsolete specific RNA polymerase II transcription factor activity(GO:0003704)
0.0	0.3	GO:0015248	sterol transporter activity(GO:0015248)
0.0	0.1	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0098988	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	2.2	GO:0016881	acid-amino acid ligase activity(GO:0016881)
0.0	0.4	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.4	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.8	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0042287	MHC protein binding(GO:0042287)
0.0	0.6	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.2	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.6	GO:0032947	protein complex scaffold(GO:0032947)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.3	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.3	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.5	GO:0061733	peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.6	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.0	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	2.0	GO:0016779	nucleotidyltransferase activity(GO:0016779)
0.0	0.3	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.4	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.1	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.4	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0016409	palmitoyltransferase activity(GO:0016409)
0.0	0.1	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.6	GO:0016860	intramolecular oxidoreductase activity(GO:0016860)
0.0	0.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.0	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.2	GO:0051087	chaperone binding(GO:0051087)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.2	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.0	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	1.3	GO:0051082	unfolded protein binding(GO:0051082)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	1.7	GO:0000287	magnesium ion binding(GO:0000287)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0048256	flap endonuclease activity(GO:0048256)
0.0	0.0	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0030331	estrogen receptor binding(GO:0030331)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.4	GO:0003954	NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.1	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.2	GO:0022884	macromolecule transmembrane transporter activity(GO:0022884)
0.0	0.5	GO:0005319	lipid transporter activity(GO:0005319)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	1.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.2	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.0	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.0	GO:0008443	6-phosphofructo-2-kinase activity(GO:0003873) phosphofructokinase activity(GO:0008443)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.3	GO:0019843	rRNA binding(GO:0019843)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.9	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	1.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	1.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	2.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	0.7	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	0.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	2.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	0.5	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.1	0.6	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	0.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	0.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	1.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.0	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.6	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.6	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.4	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	0.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.9	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.4	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	2.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.5	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.7	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.6	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	0.7	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	1.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.6	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.5	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.3	PID FOXO PATHWAY	FoxO family signaling
0.0	0.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.1	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	0.2	PID P73PATHWAY	p73 transcription factor network
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.5	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	0.2	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	0.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.6	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.1	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.1	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.3	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	6.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	0.7	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	0.9	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1	1.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	2.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	2.1	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	1.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	0.8	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	0.1	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.1	0.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	1.0	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1	1.4	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.1	1.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	1.7	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.6	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	0.9	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	0.1	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1	0.4	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.5	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.6	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.9	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.7	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.3	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.4	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.4	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.6	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0	0.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	3.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.9	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.4	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.5	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.5	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.8	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.4	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	3.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	2.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.2	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.8	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	1.1	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.4	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.4	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.6	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.3	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.2	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.3	REACTOME INTERFERON SIGNALING	Genes involved in Interferon Signaling
0.0	0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	1.5	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	0.2	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.7	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.3	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.0	0.0	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.6	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.9	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.1	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	0.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.2	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.1	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.2	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Results for IRF3

Z-value: 2.56

Motif logo

Transcription factors associated with IRF3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the IRF3 motif across conditions

Conditions sorted by the z-value of the IRF3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: