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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for IRF9

Z-value: 1.60

Motif logo

Transcription factors associated with IRF9

Gene Symbol	Gene ID	Gene Info
IRF9 Ensembl NCBI GeneCards UniProt	ENSG00000213928.4	IRF9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
IRF9	chr14_24632071_24632222	59	0.907519	-0.54	1.3e-01	Click!
IRF9	chr14_24630498_24631577	527	0.470111	0.24	5.4e-01	Click!
IRF9	chr14_24632318_24632469	188	0.816439	0.22	5.6e-01	Click!
IRF9	chr14_24634563_24634714	2433	0.091041	-0.21	5.8e-01	Click!
IRF9	chr14_24636130_24636281	4000	0.067793	-0.08	8.4e-01	Click!

Activity of the IRF9 motif across conditions

Conditions sorted by the z-value of the IRF9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_75263884_75264078	1.29	EREG	epiregulin	33121	0.14
chr13_49832065_49832609	1.03	CDADC1	cytidine and dCMP deaminase domain containing 1	10153	0.23
chr4_15549233_15549384	0.92	RP11-799M12.2		16568	0.21
chr1_78392239_78392485	0.91	NEXN	nexilin (F actin binding protein)	8549	0.18
chr6_44900994_44901181	0.89	SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	22160	0.28
chr9_139990412_139990681	0.86	ENSG00000199411	.	1749	0.12
chr7_140075788_140076381	0.85	ENSG00000238868	.	618	0.63
chr2_240302618_240303103	0.83	HDAC4	histone deacetylase 4	19783	0.17
chr7_3134520_3134947	0.81	CARD11	caspase recruitment domain family, member 11	51154	0.14
chr2_158301478_158301629	0.80	CYTIP	cytohesin 1 interacting protein	899	0.62
chr7_2445424_2445909	0.79	CHST12	carbohydrate (chondroitin 4) sulfotransferase 12	1932	0.35
chr16_25060772_25060995	0.76	ARHGAP17	Rho GTPase activating protein 17	33896	0.18
chr8_117396611_117396811	0.76	ENSG00000264815	.	97123	0.09
chr2_86079968_86080395	0.75	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	14596	0.17
chrX_25086022_25086209	0.75	ENSG00000240439	.	7059	0.28
chr17_6659349_6659686	0.74	XAF1	XIAP associated factor 1	131	0.95
chr8_142244970_142245137	0.71	SLC45A4	solute carrier family 45, member 4	4606	0.17
chr13_28696488_28696678	0.71	PAN3-AS1	PAN3 antisense RNA 1	15747	0.17
chr12_28406339_28406704	0.71	CCDC91	coiled-coil domain containing 91	3137	0.33
chr6_152504718_152504928	0.70	SYNE1	spectrin repeat containing, nuclear envelope 1	15324	0.29
chr9_90664194_90664345	0.69	ENSG00000271923	.	51019	0.15
chr2_40008252_40008657	0.68	THUMPD2	THUMP domain containing 2	2047	0.37
chr5_58055562_58056142	0.67	RP11-479O16.1		24754	0.24
chr21_37670502_37670679	0.67	MORC3	MORC family CW-type zinc finger 3	21897	0.13
chr2_162101279_162101855	0.65	AC009299.2		6106	0.21
chr5_126098116_126098351	0.64	ENSG00000252185	.	7124	0.23
chr7_139680542_139680798	0.62	PARP12	poly (ADP-ribose) polymerase family, member 12	46448	0.16
chr12_121476370_121477291	0.62	OASL	2'-5'-oligoadenylate synthetase-like	80	0.96
chr1_45516840_45517014	0.62	ENSG00000264650	.	17235	0.16
chr11_104669483_104669764	0.61	CASP12	caspase 12 (gene/pseudogene)	99518	0.08
chr21_15914339_15914644	0.61	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	4171	0.29
chr13_28365022_28365726	0.61	GSX1	GS homeobox 1	1406	0.47
chr10_135093012_135093163	0.60	ADAM8	ADAM metallopeptidase domain 8	2715	0.14
chr14_50366151_50366383	0.60	ENSG00000251929	.	2401	0.2
chr1_42995299_42995540	0.60	CCDC30	coiled-coil domain containing 30	5141	0.22
chr7_7298568_7298818	0.60	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	24742	0.22
chrX_12986243_12986394	0.60	TMSB4X	thymosin beta 4, X-linked	6909	0.23
chr21_25801249_25801648	0.60	ENSG00000232512	.	671997	0.0
chr17_29485980_29486219	0.58	RP11-142O6.1		25899	0.14
chr22_40858602_40858925	0.58	MKL1	megakaryoblastic leukemia (translocation) 1	659	0.7
chr13_31348514_31348665	0.58	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	38944	0.19
chr21_42733772_42734512	0.57	MX2	myxovirus (influenza virus) resistance 2 (mouse)	208	0.95
chr19_47026380_47026531	0.57	PNMAL2	paraneoplastic Ma antigen family-like 2	26700	0.11
chr18_60173458_60173677	0.57	ZCCHC2	zinc finger, CCHC domain containing 2	16673	0.25
chr10_26109879_26110030	0.57	ENSG00000251711	.	1599	0.44
chr2_240217343_240217562	0.56	ENSG00000265215	.	9705	0.19
chr3_192201108_192201259	0.56	FGF12-AS2	FGF12 antisense RNA 2	31628	0.16
chr12_68383944_68384095	0.56	IFNG-AS1	IFNG antisense RNA 1	710	0.81
chr7_106507255_106507406	0.56	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1406	0.54
chr15_55973905_55974056	0.55	RP11-420M1.2		1397	0.45
chr1_85645360_85645511	0.55	SYDE2	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	21294	0.16
chr5_39201497_39202174	0.55	FYB	FYN binding protein	1294	0.59
chr17_76768494_76768645	0.54	CYTH1	cytohesin 1	9785	0.19
chr13_41068422_41068589	0.54	AL133318.1	Uncharacterized protein	42818	0.18
chr3_114913699_114913850	0.53	ZBTB20	zinc finger and BTB domain containing 20	47656	0.2
chr1_67235326_67235808	0.53	TCTEX1D1	Tctex1 domain containing 1	17424	0.16
chr2_235399576_235400049	0.53	ARL4C	ADP-ribosylation factor-like 4C	5432	0.35
chr6_128229281_128229524	0.53	THEMIS	thymocyte selection associated	7176	0.3
chr10_15250983_15251323	0.53	RP11-25G10.2		28338	0.18
chr4_90220151_90220996	0.53	GPRIN3	GPRIN family member 3	8588	0.31
chr2_65047191_65047451	0.52	ENSG00000239891	.	2809	0.25
chr3_69795242_69795393	0.52	MITF	microphthalmia-associated transcription factor	6695	0.26
chr5_32583768_32584065	0.51	SUB1	SUB1 homolog (S. cerevisiae)	1689	0.49
chr5_138720842_138721347	0.51	SLC23A1	solute carrier family 23 (ascorbic acid transporter), member 1	852	0.41
chr12_9801609_9802018	0.51	RP11-705C15.4		1208	0.34
chr13_49079711_49079862	0.50	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	27427	0.22
chr2_182029964_182030146	0.50	ENSG00000266705	.	140324	0.05
chr16_85981359_85981545	0.49	IRF8	interferon regulatory factor 8	33533	0.2
chr8_42742851_42743002	0.49	ENSG00000242719	.	6547	0.13
chr1_8443286_8443442	0.49	RERE	arginine-glutamic acid dipeptide (RE) repeats	18466	0.17
chr14_91488738_91489174	0.48	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	37522	0.15
chr15_65187803_65188133	0.47	ENSG00000264929	.	4470	0.17
chrX_96221078_96221229	0.47	RPA4	replication protein A4, 30kDa	82246	0.11
chr12_62658631_62659028	0.47	USP15	ubiquitin specific peptidase 15	4620	0.23
chr2_164719052_164719232	0.46	FIGN	fidgetin	126620	0.06
chrX_41190531_41191099	0.46	DDX3X	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	1836	0.31
chr12_40077019_40077550	0.45	C12orf40	chromosome 12 open reading frame 40	57299	0.13
chr2_26016338_26016489	0.45	ASXL2	additional sex combs like 2 (Drosophila)	13235	0.24
chr11_82873492_82873814	0.45	PCF11	PCF11 cleavage and polyadenylation factor subunit	5452	0.18
chr11_108040783_108041103	0.45	NPAT	nuclear protein, ataxia-telangiectasia locus	8051	0.17
chr7_33078848_33079779	0.44	NT5C3A	5'-nucleotidase, cytosolic IIIA	1208	0.42
chr14_71338943_71339141	0.44	PCNX	pecanex homolog (Drosophila)	35080	0.2
chr6_13338388_13338539	0.44	TBC1D7	TBC1 domain family, member 7	9648	0.21
chr19_35531341_35531561	0.44	HPN	hepsin	41	0.95
chr2_1028039_1028190	0.44	AC114808.3		35913	0.18
chr2_226329396_226329663	0.43	NYAP2	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	55932	0.18
chr2_204718048_204718377	0.43	CTLA4	cytotoxic T-lymphocyte-associated protein 4	14297	0.24
chr5_52336982_52337335	0.43	CTD-2366F13.2		48140	0.12
chr5_148188804_148189074	0.43	ADRB2	adrenoceptor beta 2, surface	17217	0.25
chr1_174959503_174960178	0.42	ENSG00000252552	.	5821	0.15
chr12_93830509_93830660	0.42	UBE2N	ubiquitin-conjugating enzyme E2N	4448	0.18
chr1_84609962_84610447	0.42	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	250	0.95
chr14_98087128_98087308	0.41	ENSG00000240730	.	90708	0.1
chr12_10021470_10021931	0.41	CLEC2B	C-type lectin domain family 2, member B	1035	0.4
chr2_175498427_175499207	0.41	WIPF1	WAS/WASL interacting protein family, member 1	490	0.83
chr10_33775891_33776280	0.40	NRP1	neuropilin 1	150895	0.04
chrX_119619280_119620483	0.40	LAMP2	lysosomal-associated membrane protein 2	16661	0.2
chr1_215744331_215744482	0.40	KCTD3	potassium channel tetramerization domain containing 3	2723	0.39
chr17_38483011_38483310	0.40	RARA	retinoic acid receptor, alpha	8623	0.11
chr1_51980736_51980982	0.40	RP11-191G24.1		3122	0.2
chr12_66311785_66312262	0.40	AC090673.2	Uncharacterized protein	5944	0.2
chr12_27676423_27676945	0.40	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	320	0.91
chr14_84755354_84755505	0.40	ENSG00000251895	.	450857	0.01
chr13_40532608_40532878	0.39	ENSG00000212553	.	101379	0.08
chr1_154915200_154915451	0.39	PMVK	phosphomevalonate kinase	5858	0.09
chr16_81030456_81031156	0.39	CMC2	C-x(9)-C motif containing 2	1458	0.31
chr17_71139370_71139564	0.39	SSTR2	somatostatin receptor 2	21684	0.17
chr1_178045334_178045485	0.39	RASAL2	RAS protein activator like 2	17455	0.28
chr7_154996931_154997229	0.38	AC099552.4	Uncharacterized protein	6934	0.22
chr9_139796334_139796685	0.38	TRAF2	TNF receptor-associated factor 2	12522	0.07
chr4_154449244_154449395	0.38	KIAA0922	KIAA0922	27729	0.22
chr4_184949529_184949975	0.38	STOX2	storkhead box 2	27274	0.21
chr3_111043169_111043480	0.38	CD96	CD96 molecule	31758	0.24
chr1_160676943_160677601	0.38	CD48	CD48 molecule	4321	0.18
chr1_160489868_160490211	0.37	SLAMF6	SLAM family member 6	2993	0.18
chr9_36493105_36493256	0.37	MELK	maternal embryonic leucine zipper kinase	79679	0.1
chr10_70989347_70989498	0.37	RP11-227H15.4		2824	0.21
chr13_41558712_41559488	0.37	ELF1	E74-like factor 1 (ets domain transcription factor)	2682	0.29
chr3_52309275_52309582	0.37	WDR82	WD repeat domain 82	2909	0.12
chr10_32655030_32655181	0.37	EPC1	enhancer of polycomb homolog 1 (Drosophila)	12621	0.13
chr4_82415207_82415715	0.37	RASGEF1B	RasGEF domain family, member 1B	22392	0.28
chr13_74806763_74806914	0.36	ENSG00000206617	.	56513	0.16
chr3_4867321_4867754	0.36	ENSG00000239126	.	52849	0.14
chr2_201238051_201238202	0.36	ENSG00000201649	.	228	0.93
chr2_7017776_7018587	0.36	RSAD2	radical S-adenosyl methionine domain containing 2	385	0.85
chr15_58702506_58703018	0.36	LIPC	lipase, hepatic	6	0.98
chr2_38981773_38982016	0.36	GEMIN6	gem (nuclear organelle) associated protein 6	3218	0.21
chr21_42797993_42798388	0.36	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	22	0.98
chr12_51716816_51717143	0.35	BIN2	bridging integrator 2	920	0.52
chr22_30617100_30617291	0.35	RP3-438O4.4		14097	0.11
chr11_102187585_102188027	0.35	BIRC3	baculoviral IAP repeat containing 3	420	0.82
chr15_57475648_57475933	0.35	TCF12	transcription factor 12	35838	0.21
chr10_3514525_3515428	0.35	RP11-184A2.3		278283	0.01
chr5_133407199_133407350	0.35	TCF7	transcription factor 7 (T-cell specific, HMG-box)	43128	0.15
chr19_12807522_12807697	0.35	FBXW9	F-box and WD repeat domain containing 9	152	0.87
chr16_68503734_68504345	0.35	ENSG00000199263	.	4528	0.18
chr7_88632213_88632768	0.35	C7orf62	chromosome 7 open reading frame 62	207455	0.03
chr12_79364195_79364346	0.35	SYT1	synaptotagmin I	6455	0.31
chr6_159463569_159463720	0.34	TAGAP	T-cell activation RhoGTPase activating protein	2406	0.29
chr4_113006479_113006630	0.34	C4orf32	chromosome 4 open reading frame 32	59999	0.14
chr2_50167895_50168182	0.34	NRXN1	neurexin 1	33303	0.22
chr10_31287025_31287176	0.34	ZNF438	zinc finger protein 438	1346	0.57
chr6_25367391_25367687	0.33	ENSG00000207490	.	16288	0.18
chr5_158302177_158302618	0.33	CTD-2363C16.1		107617	0.07
chr12_46062870_46063096	0.33	ARID2	AT rich interactive domain 2 (ARID, RFX-like)	60465	0.15
chr5_81074467_81075538	0.33	SSBP2	single-stranded DNA binding protein 2	27930	0.25
chr12_6736731_6736882	0.33	LPAR5	lysophosphatidic acid receptor 5	4009	0.1
chr13_48895006_48895418	0.33	RB1	retinoblastoma 1	17301	0.25
chr14_101315771_101315992	0.33	ENSG00000214548	.	236	0.69
chr4_144326518_144326669	0.33	GAB1	GRB2-associated binding protein 1	13930	0.23
chr17_78237440_78238417	0.33	RNF213	ring finger protein 213	3259	0.2
chr7_144509813_144510191	0.32	TPK1	thiamin pyrophosphokinase 1	23144	0.23
chr19_11159843_11160026	0.32	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	9577	0.14
chr17_66196156_66196600	0.32	AMZ2	archaelysin family metallopeptidase 2	47337	0.11
chr12_124941723_124942278	0.32	NCOR2	nuclear receptor corepressor 2	26315	0.25
chr8_124049779_124050367	0.32	TBC1D31	TBC1 domain family, member 31	4135	0.17
chr2_158295494_158296053	0.32	CYTIP	cytohesin 1 interacting protein	153	0.96
chr20_49100210_49100461	0.32	PTPN1	protein tyrosine phosphatase, non-receptor type 1	26556	0.16
chr14_90190957_90191587	0.32	ENSG00000200312	.	12417	0.22
chrY_15016828_15017148	0.32	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	246	0.96
chr1_228457303_228457498	0.32	RP5-1139B12.2		4698	0.13
chr10_70444201_70444500	0.32	RP11-119F7.5		13907	0.15
chr3_100384136_100384305	0.32	ENSG00000252989	.	19255	0.19
chr7_30766967_30767188	0.32	INMT	indolethylamine N-methyltransferase	24674	0.16
chrX_154012069_154012228	0.32	ENSG00000206693	.	8875	0.12
chrX_131624482_131624759	0.32	MBNL3	muscleblind-like splicing regulator 3	624	0.83
chr13_26421188_26421471	0.31	AL138815.1	Uncharacterized protein	20732	0.21
chr5_158633120_158633309	0.31	RNF145	ring finger protein 145	1428	0.38
chr10_102985313_102985579	0.31	LBX1-AS1	LBX1 antisense RNA 1 (head to head)	3905	0.17
chr5_56114546_56115097	0.31	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	3420	0.24
chr3_71538892_71539043	0.31	ENSG00000221264	.	52273	0.14
chr12_15650638_15650843	0.31	PTPRO	protein tyrosine phosphatase, receptor type, O	48546	0.18
chr3_153005612_153005763	0.31	ENSG00000265813	.	87881	0.09
chr6_13436227_13436378	0.31	GFOD1	glucose-fructose oxidoreductase domain containing 1	27933	0.16
chr3_63965361_63965766	0.31	ATXN7	ataxin 7	12143	0.14
chr17_181340_181491	0.30	ENSG00000262061	.	419	0.56
chr10_102897939_102898090	0.30	RP11-31L23.3		1454	0.29
chr2_181528279_181528430	0.30	ENSG00000264976	.	46421	0.21
chr5_14595155_14595651	0.30	FAM105A	family with sequence similarity 105, member A	13519	0.24
chr4_90239487_90239778	0.30	GPRIN3	GPRIN family member 3	10471	0.3
chr11_60214184_60214345	0.30	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	8961	0.16
chr19_4915707_4915936	0.30	ARRDC5	arrestin domain containing 5	12942	0.12
chr11_122748654_122748805	0.30	C11orf63	chromosome 11 open reading frame 63	4662	0.22
chr10_173746_173998	0.30	ZMYND11	zinc finger, MYND-type containing 11	6533	0.24
chr12_9884469_9884620	0.30	CLECL1	C-type lectin-like 1	1171	0.42
chr1_121200380_121200843	0.29	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	264674	0.02
chr5_139047564_139047990	0.29	CXXC5	CXXC finger protein 5	7244	0.22
chr7_7287609_7287760	0.29	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	13733	0.24
chr15_60942503_60942673	0.29	RORA	RAR-related orphan receptor A	22926	0.19
chr5_118673119_118673270	0.29	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	4324	0.24
chr3_125654138_125654289	0.29	ALG1L	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	1669	0.35
chrX_23791425_23791576	0.28	ACOT9	acyl-CoA thioesterase 9	6908	0.14
chr15_68591382_68591806	0.28	FEM1B	fem-1 homolog b (C. elegans)	9044	0.21
chr20_52204433_52204907	0.28	ZNF217	zinc finger protein 217	5034	0.21
chr13_52769267_52769418	0.27	MRPS31P5	mitochondrial ribosomal protein S31 pseudogene 5	829	0.66
chr1_62905567_62905816	0.27	USP1	ubiquitin specific peptidase 1	3365	0.33
chr20_8194475_8194883	0.27	PLCB1-IT1	PLCB1 intronic transcript 1 (non-protein coding)	34672	0.21
chr8_102543926_102544126	0.27	GRHL2	grainyhead-like 2 (Drosophila)	39040	0.17
chr18_77157446_77157699	0.27	NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	1347	0.51
chr13_24540637_24541010	0.27	SPATA13	spermatogenesis associated 13	13121	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.3	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.1	0.3	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.2	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.2	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.1	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.1	0.3	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.3	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.3	GO:0032727	positive regulation of interferon-alpha production(GO:0032727)
0.0	0.1	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.3	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	1.9	GO:0034340	response to type I interferon(GO:0034340)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.2	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.4	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.3	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.4	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.0	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.3	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.0	GO:0010560	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0010042	response to manganese ion(GO:0010042)
0.0	0.1	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.0	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.2	GO:0071445	obsolete cellular response to protein stimulus(GO:0071445)
0.0	0.1	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.2	GO:0009595	detection of biotic stimulus(GO:0009595)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.1	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.0	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) negative regulation of glial cell proliferation(GO:0060253)
0.0	0.3	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.0	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0015919	peroxisomal membrane transport(GO:0015919)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.6	GO:0051607	defense response to virus(GO:0051607)
0.0	0.0	GO:1903514	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0060134	prepulse inhibition(GO:0060134)
0.0	0.0	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.0	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031045	dense core granule(GO:0031045)
0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	GO:0005638	lamin filament(GO:0005638)
0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.3	GO:0031672	A band(GO:0031672)
0.3	GO:0030914	STAGA complex(GO:0030914)
0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.1	GO:0030904	retromer complex(GO:0030904)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.4	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	GO:0005652	nuclear lamina(GO:0005652)
0.1	GO:0001741	XY body(GO:0001741)
0.0	GO:0032009	early phagosome(GO:0032009)
0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	GO:0031932	TORC2 complex(GO:0031932)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.4	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.4	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.3	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.4	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.7	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.2	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.0	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.0	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.5	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.0	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.3	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.5	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	PID MYC PATHWAY	C-MYC pathway
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.5	PID RHOA PATHWAY	RhoA signaling pathway
0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	PID IL2 1PATHWAY	IL2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.6	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	1.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.5	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.5	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.0	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling