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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for IRX5

Z-value: 1.13

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Transcription factors associated with IRX5

Gene Symbol	Gene ID	Gene Info
IRX5 Ensembl NCBI GeneCards UniProt	ENSG00000176842.10	iroquois homeobox 5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr16_55035965_55036116	IRX5	70056	0.135818	-0.70	3.6e-02	Click!
chr16_54964668_54964927	IRX5	23	0.989203	0.67	5.0e-02	Click!
chr16_55125407_55125558	IRX5	159498	0.038565	-0.52	1.5e-01	Click!
chr16_54969072_54969449	IRX5	3276	0.398476	-0.47	2.0e-01	Click!
chr16_54969464_54969709	IRX5	3602	0.385865	-0.47	2.0e-01	Click!

Activity of the IRX5 motif across conditions

Conditions sorted by the z-value of the IRX5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_106547367_106547905	1.21	RP1-134E15.3		379	0.74
chr13_104877838_104878137	1.15	NA	NA	> 10⁶	NA
chr5_96269079_96269469	0.91	LNPEP	leucyl/cystinyl aminopeptidase	1894	0.31
chr7_23518547_23518698	0.90	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	8536	0.17
chr11_104904746_104905919	0.89	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chr2_143886988_143887259	0.83	ARHGAP15	Rho GTPase activating protein 15	240	0.95
chr21_46339892_46340194	0.83	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	727	0.4
chr12_40076724_40077004	0.81	C12orf40	chromosome 12 open reading frame 40	56879	0.14
chr16_11887784_11888260	0.79	ZC3H7A	zinc finger CCCH-type containing 7A	2361	0.24
chr4_40202041_40202542	0.79	RHOH	ras homolog family member H	327	0.9
chr7_50345819_50346403	0.77	IKZF1	IKAROS family zinc finger 1 (Ikaros)	1733	0.5
chr7_38576145_38576296	0.77	ENSG00000241756	.	5281	0.31
chr14_81789363_81789514	0.74	STON2	stonin 2	46161	0.18
chr15_93457570_93457977	0.74	CHD2	chromodomain helicase DNA binding protein 2	10070	0.2
chr3_151922835_151923340	0.73	MBNL1	muscleblind-like splicing regulator 1	62742	0.13
chr1_84556504_84556817	0.73	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	12833	0.27
chr11_104971227_104972126	0.73	CASP1	caspase 1, apoptosis-related cysteine peptidase	482	0.32
chr12_4377755_4378334	0.72	CCND2	cyclin D2	4894	0.19
chr10_15296464_15296906	0.71	RP11-25G10.2		17194	0.24
chr7_150264558_150265605	0.70	GIMAP4	GTPase, IMAP family member 4	557	0.78
chr8_22838473_22838652	0.70	ENSG00000240116	.	3172	0.17
chr2_109238100_109238434	0.69	LIMS1	LIM and senescent cell antigen-like domains 1	545	0.82
chr6_106961305_106961653	0.69	AIM1	absent in melanoma 1	1749	0.38
chr17_29641266_29641417	0.68	EVI2B	ecotropic viral integration site 2B	211	0.9
chr4_109086470_109087224	0.67	LEF1	lymphoid enhancer-binding factor 1	610	0.72
chr12_25207113_25207806	0.67	LRMP	lymphoid-restricted membrane protein	1785	0.37
chr1_192775406_192775557	0.66	RGS2	regulator of G-protein signaling 2, 24kDa	2690	0.37
chr3_71409819_71409970	0.66	FOXP1	forkhead box P1	55983	0.15
chr3_111261315_111261845	0.66	CD96	CD96 molecule	583	0.82
chr5_130175429_130175580	0.65	HINT1	histidine triad nucleotide binding protein 1	322816	0.01
chr8_134085197_134085362	0.65	SLA	Src-like-adaptor	12676	0.24
chr6_35568962_35570321	0.65	ENSG00000212579	.	49954	0.1
chr1_234545000_234545174	0.63	COA6	cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)	35640	0.12
chr5_130617597_130618118	0.63	CDC42SE2	CDC42 small effector 2	18064	0.27
chr1_192546230_192546423	0.62	RGS1	regulator of G-protein signaling 1	1423	0.45
chr17_29638804_29639264	0.62	EVI2B	ecotropic viral integration site 2B	2068	0.22
chr1_198492691_198493057	0.62	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	16930	0.28
chr2_166031255_166031406	0.62	SCN3A	sodium channel, voltage-gated, type III, alpha subunit	11734	0.22
chr14_22961374_22961769	0.61	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	5400	0.11
chr10_5753060_5753327	0.61	RP11-336A10.2		3193	0.23
chr10_28622520_28622887	0.60	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	712	0.72
chr3_111267390_111267660	0.59	CD96	CD96 molecule	6528	0.27
chr16_87889371_87889596	0.58	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	7762	0.18
chr10_129846333_129846652	0.58	PTPRE	protein tyrosine phosphatase, receptor type, E	658	0.81
chr5_67576418_67576636	0.58	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	392	0.92
chr3_176919226_176919959	0.57	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	4331	0.31
chr17_74749862_74750103	0.57	ENSG00000200257	.	988	0.35
chr14_22992791_22992997	0.55	TRAJ15	T cell receptor alpha joining 15	5686	0.12
chr14_22966536_22967037	0.55	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	10615	0.1
chr16_50778559_50778897	0.55	RP11-327F22.1		2002	0.17
chr18_33550373_33550669	0.55	C18orf21	chromosome 18 open reading frame 21	1525	0.4
chr3_151922606_151922776	0.54	MBNL1	muscleblind-like splicing regulator 1	63138	0.12
chr3_32856381_32856532	0.54	TRIM71	tripartite motif containing 71, E3 ubiquitin protein ligase	3054	0.33
chr10_11213825_11214053	0.54	RP3-323N1.2		600	0.77
chr5_140996135_140996687	0.54	AC008781.7		1570	0.23
chr7_138790255_138790726	0.54	ZC3HAV1	zinc finger CCCH-type, antiviral 1	3610	0.26
chr18_56326442_56326593	0.53	MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	12101	0.14
chr16_4528036_4528453	0.53	HMOX2	heme oxygenase (decycling) 2	1784	0.22
chr8_82020048_82020268	0.53	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	4145	0.34
chr14_99681730_99682557	0.53	AL109767.1		47142	0.14
chr12_47611625_47611801	0.53	PCED1B	PC-esterase domain containing 1B	1332	0.49
chr15_34626880_34627184	0.53	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	2013	0.2
chr1_84610970_84611403	0.52	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1232	0.6
chrX_78205532_78205824	0.52	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	4760	0.35
chr15_45005481_45005930	0.52	B2M	beta-2-microglobulin	1990	0.25
chr2_197033343_197033494	0.52	STK17B	serine/threonine kinase 17b	2306	0.31
chr1_100817332_100817558	0.52	CDC14A	cell division cycle 14A	155	0.96
chr3_101230268_101230559	0.52	SENP7	SUMO1/sentrin specific peptidase 7	1615	0.33
chr17_75449797_75450115	0.51	SEPT9	septin 9	49	0.97
chr3_69248462_69249135	0.51	FRMD4B	FERM domain containing 4B	377	0.9
chr12_50615145_50616830	0.51	LIMA1	LIM domain and actin binding 1	144	0.93
chr2_52029885_52030036	0.51	ENSG00000222692	.	367604	0.01
chr10_11210404_11210686	0.51	RP3-323N1.2		2794	0.27
chr2_143887583_143887860	0.51	ARHGAP15	Rho GTPase activating protein 15	838	0.72
chr5_130883505_130884015	0.51	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	15034	0.29
chr18_24058097_24058248	0.51	KCTD1	potassium channel tetramerization domain containing 1	68791	0.11
chr9_102515687_102515838	0.51	NR4A3	nuclear receptor subfamily 4, group A, member 3	68375	0.13
chr4_90603546_90603697	0.51	RP11-115D19.1		958	0.71
chr12_52885749_52885900	0.51	KRT6A	keratin 6A	1217	0.31
chr21_36341148_36341299	0.50	RUNX1	runt-related transcription factor 1	79136	0.12
chr4_143325352_143326244	0.50	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	26614	0.28
chr2_196122609_196122760	0.50	ENSG00000202206	.	256076	0.02
chr2_161055572_161055723	0.50	ITGB6	integrin, beta 6	1116	0.65
chr7_130610833_130610984	0.49	ENSG00000226380	.	48610	0.15
chr14_29433147_29433298	0.49	ENSG00000252065	.	18394	0.24
chr17_33567122_33567465	0.49	RP11-799D4.4		2293	0.22
chr6_12010262_12011396	0.49	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	1404	0.51
chr5_35859258_35859647	0.48	IL7R	interleukin 7 receptor	2458	0.3
chr3_135910574_135910951	0.48	MSL2	male-specific lethal 2 homolog (Drosophila)	2634	0.36
chr7_2934045_2934372	0.48	CARD11	caspase recruitment domain family, member 11	35486	0.16
chr12_47610316_47610761	0.48	PCED1B	PC-esterase domain containing 1B	157	0.96
chr8_30278844_30278995	0.48	RBPMS	RNA binding protein with multiple splicing	21214	0.21
chr2_202126146_202126672	0.48	CASP8	caspase 8, apoptosis-related cysteine peptidase	270	0.92
chr15_50151299_50151450	0.48	ATP8B4	ATPase, class I, type 8B, member 4	17518	0.21
chr3_168234505_168234656	0.48	ENSG00000207717	.	35062	0.2
chr20_48286611_48286855	0.48	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	43682	0.13
chr17_35713619_35713770	0.47	ACACA	acetyl-CoA carboxylase alpha	2345	0.26
chr2_64457274_64457425	0.47	AC074289.1		1747	0.47
chr18_13019627_13019778	0.47	CEP192	centrosomal protein 192kDa	10084	0.21
chr13_76336288_76336793	0.47	LMO7	LIM domain 7	1743	0.47
chr5_56326185_56326717	0.47	MIER3	mesoderm induction early response 1, family member 3	58949	0.11
chr2_202127394_202127951	0.47	CASP8	caspase 8, apoptosis-related cysteine peptidase	993	0.56
chr2_204801338_204802214	0.46	ICOS	inducible T-cell co-stimulator	273	0.95
chr3_108541842_108541993	0.46	TRAT1	T cell receptor associated transmembrane adaptor 1	298	0.94
chr20_52212281_52212484	0.46	ZNF217	zinc finger protein 217	2004	0.34
chr5_169723230_169723381	0.46	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	1926	0.38
chr1_65530999_65531150	0.46	ENSG00000199135	.	6883	0.2
chr11_98660793_98660944	0.46	CNTN5	contactin 5	231003	0.02
chr9_92151090_92151365	0.45	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	38182	0.17
chr5_150287253_150287404	0.45	ZNF300	zinc finger protein 300	2783	0.27
chr5_148207768_148208716	0.45	ADRB2	adrenoceptor beta 2, surface	2086	0.43
chr4_87761462_87761613	0.45	SLC10A6	solute carrier family 10 (sodium/bile acid cotransporter), member 6	8879	0.26
chr18_73180620_73180771	0.45	SMIM21	small integral membrane protein 21	41037	0.19
chr5_40686354_40686614	0.45	PTGER4	prostaglandin E receptor 4 (subtype EP4)	6884	0.22
chr16_25060772_25060995	0.45	ARHGAP17	Rho GTPase activating protein 17	33896	0.18
chr10_45916550_45916701	0.44	RP11-67C2.2		31944	0.18
chr6_54583024_54583175	0.44	ENSG00000251946	.	68086	0.13
chr18_29677001_29677152	0.44	ENSG00000238982	.	2609	0.18
chr15_93427420_93428173	0.44	CHD2	chromodomain helicase DNA binding protein 2	1270	0.45
chr10_54574083_54574234	0.44	ENSG00000201196	.	38209	0.17
chr17_41281855_41282006	0.43	NBR2	neighbor of BRCA1 gene 2 (non-protein coding)	1295	0.35
chr10_11209293_11209598	0.43	CELF2	CUGBP, Elav-like family member 2	1954	0.35
chr20_55965895_55966111	0.43	RBM38	RNA binding motif protein 38	460	0.74
chr12_12712693_12713134	0.43	DUSP16	dual specificity phosphatase 16	1098	0.58
chr12_103888876_103889092	0.43	C12orf42	chromosome 12 open reading frame 42	747	0.75
chr13_102279386_102279657	0.43	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	29026	0.25
chr7_150148744_150149359	0.43	GIMAP8	GTPase, IMAP family member 8	1333	0.41
chr14_64389363_64389514	0.42	SYNE2	spectrin repeat containing, nuclear envelope 2	13622	0.25
chr12_56327336_56327517	0.42	WIBG	within bgcn homolog (Drosophila)	1024	0.3
chr19_2553269_2553420	0.42	ENSG00000252962	.	50205	0.09
chr10_72835279_72835430	0.42	UNC5B	unc-5 homolog B (C. elegans)	136973	0.04
chr4_116464375_116464526	0.42	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	429418	0.01
chr5_125785966_125786206	0.42	GRAMD3	GRAM domain containing 3	11951	0.22
chr5_76007057_76007208	0.42	F2R	coagulation factor II (thrombin) receptor	4736	0.2
chr10_15211128_15211858	0.42	NMT2	N-myristoyltransferase 2	801	0.67
chr2_201248196_201249000	0.42	ENSG00000264798	.	3300	0.23
chr5_130603474_130603777	0.42	CDC42SE2	CDC42 small effector 2	3832	0.34
chr14_35306917_35307068	0.42	ENSG00000251726	.	7574	0.17
chr4_176914992_176915143	0.42	GPM6A	glycoprotein M6A	8416	0.24
chr6_159465378_159465638	0.42	TAGAP	T-cell activation RhoGTPase activating protein	542	0.78
chr12_10096266_10096511	0.42	CLEC12A	C-type lectin domain family 12, member A	7527	0.14
chr6_24926383_24926675	0.42	FAM65B	family with sequence similarity 65, member B	9659	0.23
chr4_109084692_109084886	0.42	LEF1	lymphoid enhancer-binding factor 1	2668	0.31
chr15_93352280_93352431	0.41	CTD-2313J17.1		558	0.5
chr19_7411383_7411820	0.41	CTB-133G6.1		2247	0.26
chr18_49659359_49659510	0.41	DCC	deleted in colorectal carcinoma	207108	0.03
chr5_130617107_130617383	0.41	CDC42SE2	CDC42 small effector 2	17452	0.27
chr3_71772714_71772865	0.41	EIF4E3	eukaryotic translation initiation factor 4E family member 3	1737	0.4
chr14_102289544_102289975	0.41	CTD-2017C7.2		13101	0.14
chr9_80454914_80455065	0.41	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	17074	0.29
chr20_52198944_52199193	0.41	ZNF217	zinc finger protein 217	568	0.75
chr1_198620819_198621442	0.41	PTPRC	protein tyrosine phosphatase, receptor type, C	12838	0.23
chr17_75143197_75143348	0.41	SEC14L1	SEC14-like 1 (S. cerevisiae)	2544	0.28
chr5_85380672_85380823	0.41	NBPF22P	neuroblastoma breakpoint family, member 22, pseudogene	197837	0.03
chr11_12211451_12211602	0.41	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	27823	0.2
chr21_35304239_35304390	0.41	LINC00649	long intergenic non-protein coding RNA 649	796	0.58
chr8_133773782_133773933	0.41	TMEM71	transmembrane protein 71	981	0.56
chr1_31464589_31464832	0.41	PUM1	pumilio RNA-binding family member 1	3196	0.23
chr14_99706008_99706207	0.41	AL109767.1		23178	0.19
chr4_90226531_90226682	0.41	GPRIN3	GPRIN family member 3	2555	0.42
chr16_55560738_55560889	0.41	LPCAT2	lysophosphatidylcholine acyltransferase 2	1592	0.43
chr5_12989682_12989833	0.41	ENSG00000222717	.	185203	0.03
chr3_141107290_141107620	0.41	ZBTB38	zinc finger and BTB domain containing 38	801	0.69
chr13_73942386_73942537	0.41	ENSG00000206697	.	141177	0.05
chr18_5151726_5151877	0.40	C18orf42	chromosome 18 open reading frame 42	45423	0.19
chr2_235359483_235359634	0.40	ARL4C	ADP-ribosylation factor-like 4C	45686	0.21
chr10_63809082_63810748	0.40	ARID5B	AT rich interactive domain 5B (MRF1-like)	945	0.69
chr3_112217855_112218341	0.40	BTLA	B and T lymphocyte associated	107	0.98
chr7_33078848_33079779	0.40	NT5C3A	5'-nucleotidase, cytosolic IIIA	1208	0.42
chr8_2460458_2460609	0.40	MYOM2	myomesin 2	467349	0.01
chr21_24200887_24201038	0.40	ENSG00000263796	.	147970	0.05
chr1_89590355_89590528	0.40	GBP2	guanylate binding protein 2, interferon-inducible	1356	0.44
chrX_25812581_25812732	0.40	MAGEB18	melanoma antigen family B, 18	343804	0.01
chr14_98086795_98087003	0.40	ENSG00000240730	.	90389	0.1
chr7_50415328_50415483	0.40	IKZF1	IKAROS family zinc finger 1 (Ikaros)	48160	0.16
chr17_75469709_75469860	0.40	RP11-75C10.9		932	0.44
chrX_15870606_15870798	0.40	AP1S2	adaptor-related protein complex 1, sigma 2 subunit	66	0.98
chr14_61793464_61793615	0.39	PRKCH	protein kinase C, eta	92	0.97
chr13_71436122_71436273	0.39	ENSG00000202433	.	402601	0.01
chr9_110011277_110011428	0.39	RAD23B	RAD23 homolog B (S. cerevisiae)	34066	0.22
chr1_25889724_25889930	0.39	LDLRAP1	low density lipoprotein receptor adaptor protein 1	19756	0.18
chr6_103854523_103854674	0.39	ENSG00000202283	.	176412	0.04
chr16_53567961_53568112	0.39	AKTIP	AKT interacting protein	29713	0.19
chrX_109486064_109486215	0.39	ENSG00000208883	.	17848	0.22
chr6_163910530_163910681	0.39	QKI	QKI, KH domain containing, RNA binding	34242	0.24
chr7_130768281_130768432	0.39	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	4877	0.24
chr18_9735734_9735885	0.39	RAB31	RAB31, member RAS oncogene family	27647	0.19
chr5_167469_167620	0.39	ENSG00000199540	.	23232	0.12
chr2_43449640_43450246	0.39	ZFP36L2	ZFP36 ring finger protein-like 2	3805	0.27
chr9_3477118_3477287	0.39	AL365202.1	Uncharacterized protein	8021	0.25
chrX_44742872_44743114	0.39	ENSG00000252113	.	1758	0.38
chr4_162734925_162735076	0.39	RP11-497K21.1		208885	0.03
chr2_202125315_202125762	0.39	CASP8	caspase 8, apoptosis-related cysteine peptidase	315	0.9
chr6_21506218_21506369	0.39	SOX4	SRY (sex determining region Y)-box 4	87679	0.11
chr21_36413445_36413809	0.39	RUNX1	runt-related transcription factor 1	7835	0.33
chr8_100727439_100727796	0.39	RP11-402L5.1		83798	0.09
chr13_73631948_73632099	0.38	KLF5	Kruppel-like factor 5 (intestinal)	907	0.66
chr14_22964398_22964682	0.38	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	8369	0.1
chr5_160982600_160982751	0.38	GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	7442	0.31
chr14_22990988_22991175	0.38	TRAJ15	T cell receptor alpha joining 15	7499	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.3	0.8	GO:0010459	negative regulation of heart rate(GO:0010459)
0.3	0.8	GO:0030223	neutrophil differentiation(GO:0030223)
0.2	0.6	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2	0.2	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.2	0.5	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.2	0.5	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.5	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.5	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	1.0	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.1	0.3	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.3	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.1	0.6	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.1	0.3	GO:0006828	manganese ion transport(GO:0006828)
0.1	0.2	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1	0.3	GO:0002666	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1	0.4	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.1	0.2	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.1	0.4	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.1	0.3	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	0.4	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	0.2	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.1	0.2	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.3	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.3	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.2	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1	0.5	GO:0015671	oxygen transport(GO:0015671)
0.1	1.6	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1	0.3	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1	0.8	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.1	0.2	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.1	0.2	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.1	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.3	GO:0010761	fibroblast migration(GO:0010761)
0.1	2.2	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.1	0.2	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1	0.2	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1	0.2	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.1	0.3	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.1	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.8	GO:0033003	regulation of mast cell activation(GO:0033003)
0.1	0.2	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.1	0.1	GO:0046645	regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.1	0.2	GO:0001821	histamine secretion(GO:0001821)
0.1	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.3	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.1	0.2	GO:0045056	transcytosis(GO:0045056)
0.1	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.2	GO:0007343	egg activation(GO:0007343)
0.1	0.1	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.1	0.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0061339	establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0	0.5	GO:0031529	ruffle organization(GO:0031529)
0.0	0.7	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.2	GO:0045842	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0060559	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.5	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.2	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.3	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.2	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.2	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.2	GO:0071027	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.2	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.4	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.3	GO:0016045	detection of bacterium(GO:0016045)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.0	GO:0045409	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.2	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.2	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	2.0	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.2	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.4	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.3	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.5	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.2	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.3	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.2	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.3	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.3	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.3	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.0	GO:0061046	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) regulation of branching involved in lung morphogenesis(GO:0061046) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0048711	positive regulation of astrocyte differentiation(GO:0048711)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.6	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.1	GO:0070897	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.5	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.2	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.3	GO:0044409	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.5	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0032782	canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.3	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	1.6	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0060295	regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.2	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.4	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.2	GO:0050482	arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.2	GO:0000460	maturation of 5.8S rRNA(GO:0000460)
0.0	0.0	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.4	GO:0030010	establishment of cell polarity(GO:0030010)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.5	GO:0006997	nucleus organization(GO:0006997)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0010002	cardioblast differentiation(GO:0010002)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.0	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0051851	modification by host of symbiont morphology or physiology(GO:0051851)
0.0	0.3	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.2	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.0	GO:1903306	regulation of cellular extravasation(GO:0002691) negative regulation of regulated secretory pathway(GO:1903306)
0.0	0.0	GO:0032727	positive regulation of interferon-alpha production(GO:0032727)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.2	GO:0009303	rRNA transcription(GO:0009303)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0072193	positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0047496	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0	0.0	GO:0009595	detection of biotic stimulus(GO:0009595)
0.0	0.1	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0021544	subpallium development(GO:0021544)
0.0	0.2	GO:0007398	ectoderm development(GO:0007398)
0.0	0.2	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.5	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0043587	tongue morphogenesis(GO:0043587)
0.0	0.1	GO:0034695	response to prostaglandin E(GO:0034695)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.1	GO:0045357	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.3	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.4	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0098534	centriole replication(GO:0007099) centriole assembly(GO:0098534)
0.0	0.1	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.2	GO:0045909	positive regulation of vasodilation(GO:0045909)
0.0	0.4	GO:0072512	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.3	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.1	GO:0042119	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.3	GO:0051693	actin filament capping(GO:0051693)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.0	GO:0030573	bile acid catabolic process(GO:0030573)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0021707	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.8	GO:0097194	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) execution phase of apoptosis(GO:0097194)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.0	GO:0060968	regulation of gene silencing(GO:0060968)
0.0	0.1	GO:0017004	cytochrome complex assembly(GO:0017004)
0.0	0.1	GO:0042363	vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.3	GO:0006342	chromatin silencing(GO:0006342)
0.0	0.7	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.1	GO:0035308	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	0.6	GO:0001892	embryonic placenta development(GO:0001892)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.0	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.2	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0031663	lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.2	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.0	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	1.0	GO:0006402	mRNA catabolic process(GO:0006402)
0.0	0.1	GO:0034035	purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.0	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0002886	regulation of myeloid leukocyte mediated immunity(GO:0002886)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.3	GO:0030041	actin filament polymerization(GO:0030041)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.1	GO:0008333	endosome to lysosome transport(GO:0008333)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0009113	purine nucleobase biosynthetic process(GO:0009113)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.0	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0030835	regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0042532	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518) negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.0	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.0	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.3	GO:0006903	vesicle targeting(GO:0006903)
0.0	0.0	GO:0032743	positive regulation of interleukin-2 production(GO:0032743)
0.0	0.4	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.4	GO:0006968	cellular defense response(GO:0006968)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.0	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.2	GO:0006306	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.0	GO:0043247	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.2	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.1	GO:0043174	nucleoside salvage(GO:0043174)
0.0	0.0	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.0	GO:0006530	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.0	GO:0060253	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) glial cell proliferation(GO:0014009) Schwann cell proliferation(GO:0014010) regulation of glial cell proliferation(GO:0060251) negative regulation of glial cell proliferation(GO:0060253)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.2	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.4	GO:0072487	MSL complex(GO:0072487)
0.1	0.5	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.6	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	1.6	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	1.0	GO:0042101	T cell receptor complex(GO:0042101)
0.1	0.2	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	0.3	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	0.5	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.7	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.3	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	0.5	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	0.4	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	0.2	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.2	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	1.3	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.3	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.2	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.4	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.0	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.4	GO:0043209	myelin sheath(GO:0043209)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.5	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.6	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.2	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.4	GO:0005884	actin filament(GO:0005884)
0.0	0.5	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.3	GO:0001533	cornified envelope(GO:0001533)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.2	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.4	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
0.0	0.5	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.4	GO:0005796	Golgi lumen(GO:0005796)
0.0	1.4	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0045273	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	1.1	GO:0001726	ruffle(GO:0001726)
0.0	0.2	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.2	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0043596	nuclear replication fork(GO:0043596)
0.0	0.3	GO:0031526	brush border membrane(GO:0031526)
0.0	0.1	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.0	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	1.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.1	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.0	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.1	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.0	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.2	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.0	GO:0070761	pre-snoRNP complex(GO:0070761)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2	1.0	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2	0.7	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.3	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	1.6	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.3	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	0.7	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	1.6	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	1.4	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.2	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1	0.3	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.1	0.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	0.2	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.1	0.3	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.1	0.2	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.1	1.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1	0.2	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.1	0.8	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.1	0.8	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.5	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.2	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.2	GO:0004849	uridine kinase activity(GO:0004849)
0.1	0.2	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.2	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.2	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1	0.2	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1	0.4	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	0.3	GO:0005521	lamin binding(GO:0005521)
0.1	0.2	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.3	GO:0004904	interferon receptor activity(GO:0004904)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.2	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	0.4	GO:0005522	profilin binding(GO:0005522)
0.0	0.4	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.5	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.3	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.4	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.0	GO:0051380	norepinephrine binding(GO:0051380)
0.0	0.3	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.2	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.4	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.5	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.2	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.6	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.3	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.3	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.4	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	2.1	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.2	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0051400	BH domain binding(GO:0051400)
0.0	0.2	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.2	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.3	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	1.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.4	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.5	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.5	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.8	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.8	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0051998	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.3	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.5	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.4	GO:0016251	obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.3	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.2	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.1	GO:0042054	histone methyltransferase activity(GO:0042054)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.2	GO:0015114	phosphate ion transmembrane transporter activity(GO:0015114)
0.0	0.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.2	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.3	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.3	GO:0016790	thiolester hydrolase activity(GO:0016790)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.4	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.7	GO:0042393	histone binding(GO:0042393)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.0	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.0	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.5	GO:0008234	cysteine-type peptidase activity(GO:0008234)
0.0	0.0	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.0	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0046790	virion binding(GO:0046790)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	3.8	GO:0005525	GTP binding(GO:0005525)
0.0	0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.1	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.0	GO:0035173	histone kinase activity(GO:0035173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	1.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	3.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	0.8	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	1.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	0.2	PID ENDOTHELIN PATHWAY	Endothelins
0.0	1.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.8	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.0	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.4	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.3	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	1.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.2	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	1.0	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.9	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.4	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	1.1	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.4	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.3	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	0.0	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.2	PID EPO PATHWAY	EPO signaling pathway
0.0	0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.3	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.2	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.2	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.3	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.0	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.1	PID ATM PATHWAY	ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.9	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	1.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	1.6	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	0.7	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.5	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	1.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	1.3	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.1	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	1.1	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.7	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	2.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	1.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.4	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	1.5	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.6	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.3	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	0.2	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.2	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.4	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.4	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.3	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	2.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	1.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.3	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	0.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	0.5	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.0	REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0	0.6	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	1.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.4	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.0	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.4	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.2	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.8	REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0	0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.2	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.1	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.1	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.2	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.1	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.2	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression

Results for IRX5

Z-value: 1.13

Motif logo

Transcription factors associated with IRX5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the IRX5 motif across conditions

Conditions sorted by the z-value of the IRX5 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: