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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for IRX6_IRX4

Z-value: 1.00

Motif logo

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr5_1887316_1887467IRX4410.5066850.561.2e-01Click!
chr5_1879697_1879902IRX430590.1996260.531.4e-01Click!
chr5_1886065_1886216IRX411920.3106600.442.4e-01Click!
chr5_1882927_1883078IRX41220.9268190.343.7e-01Click!
chr5_1886412_1886563IRX48450.3921120.324.0e-01Click!
chr16_55361576_55361727IRX639790.2258580.551.2e-01Click!
chr16_55358539_55358690IRX69420.5795500.551.3e-01Click!
chr16_55359549_55359700IRX619520.3343970.481.9e-01Click!
chr16_55358328_55358505IRX67440.6714580.264.9e-01Click!
chr16_55358802_55358953IRX612050.4842010.265.0e-01Click!

Activity of the IRX6_IRX4 motif across conditions

Conditions sorted by the z-value of the IRX6_IRX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_150779976_150780304 0.66 CTSK
 cathepsin K
 230
 0.9
chr14_81789363_81789514 0.56 STON2
 stonin 2
 46161
 0.18
chr2_166031255_166031406 0.52 SCN3A
 sodium channel, voltage-gated, type III, alpha subunit
 11734
 0.22
chr6_56414295_56414544 0.52 DST
 dystonin
 75631
 0.11
chr7_117720696_117720847 0.52 NAA38
 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
 103315
 0.08
chr10_21688030_21688514 0.50 ENSG00000207264
 .
 77382
 0.08
chr12_13351250_13351500 0.50 EMP1
 epithelial membrane protein 1
 1655
 0.47
chr2_173686973_173687124 0.49 RAPGEF4
 Rap guanine nucleotide exchange factor (GEF) 4
 745
 0.77
chr2_189834539_189834690 0.49 COL3A1
 collagen, type III, alpha 1
 4432
 0.25
chr20_15680912_15681288 0.46 ENSG00000212111
 .
 141987
 0.05
chr10_52687623_52687774 0.45 A1CF
 APOBEC1 complementation factor
 42263
 0.16
chr10_29879098_29879625 0.44 ENSG00000216035
 .
 11914
 0.18
chr3_99360396_99360669 0.43 COL8A1
 collagen, type VIII, alpha 1
 3078
 0.35
chr12_42982187_42982354 0.43 PRICKLE1
 prickle homolog 1 (Drosophila)
 1208
 0.6
chr4_187491209_187491867 0.42 MTNR1A
 melatonin receptor 1A
 14817
 0.17
chr3_71295420_71295571 0.41 FOXP1
 forkhead box P1
 1179
 0.61
chr3_63748246_63748457 0.40 AC136289.1
42418
 0.14
chr8_30278844_30278995 0.40 RBPMS
 RNA binding protein with multiple splicing
 21214
 0.21
chr1_197167655_197168814 0.40 ZBTB41
 zinc finger and BTB domain containing 41
 1438
 0.4
chr1_57661483_57661634 0.40 DAB1
 Dab, reelin signal transducer, homolog 1 (Drosophila)
 95179
 0.09
chr11_121969171_121969347 0.40 ENSG00000207971
 .
 1293
 0.36
chr4_170189564_170189726 0.39 SH3RF1
 SH3 domain containing ring finger 1
 1463
 0.54
chr19_16179581_16179939 0.38 TPM4
 tropomyosin 4
 1250
 0.44
chr7_42228970_42229243 0.38 GLI3
 GLI family zinc finger 3
 38214
 0.24
chr6_80248235_80248430 0.38 LCA5
 Leber congenital amaurosis 5
 1157
 0.64
chr7_116483846_116484032 0.37 CAPZA2
 capping protein (actin filament) muscle Z-line, alpha 2
 18588
 0.19
chr1_69950952_69951103 0.36 LRRC7
 leucine rich repeat containing 7
 83054
 0.11
chr1_24739398_24739744 0.36 STPG1
 sperm-tail PG-rich repeat containing 1
 644
 0.68
chr3_98617426_98617589 0.36 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 2508
 0.26
chr9_139684873_139685024 0.36 TMEM141
 transmembrane protein 141
 859
 0.25
chr2_64017838_64018067 0.36 UGP2
 UDP-glucose pyrophosphorylase 2
 50122
 0.16
chr11_8830627_8830889 0.35 ST5
 suppression of tumorigenicity 5
 1438
 0.35
chr2_9398911_9399239 0.35 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 52181
 0.16
chr5_16549957_16550209 0.35 FAM134B
 family with sequence similarity 134, member B
 40976
 0.15
chr9_110247534_110247685 0.35 KLF4
 Kruppel-like factor 4 (gut)
 3802
 0.26
chr6_73262911_73263125 0.35 KCNQ5
 potassium voltage-gated channel, KQT-like subfamily, member 5
 68502
 0.12
chr4_177701020_177701171 0.34 VEGFC
 vascular endothelial growth factor C
 12786
 0.3
chr16_49686685_49686863 0.34 ZNF423
 zinc finger protein 423
 11362
 0.24
chr2_178196983_178197134 0.34 AC074286.1
9166
 0.12
chr12_76271592_76272084 0.33 ENSG00000243420
 .
 80072
 0.1
chr14_64389363_64389514 0.33 SYNE2
 spectrin repeat containing, nuclear envelope 2
 13622
 0.25
chr2_120064088_120064263 0.33 STEAP3-AS1
 STEAP3 antisense RNA 1
 57528
 0.1
chr15_71035707_71036127 0.33 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 19852
 0.21
chr1_192775406_192775557 0.33 RGS2
 regulator of G-protein signaling 2, 24kDa
 2690
 0.37
chr4_47488156_47488587 0.32 ATP10D
 ATPase, class V, type 10D
 1055
 0.56
chr1_33497639_33497820 0.32 AK2
 adenylate kinase 2
 4712
 0.19
chr2_10036128_10036279 0.32 TAF1B
 TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
 20076
 0.2
chr4_100739524_100739675 0.32 DAPP1
 dual adaptor of phosphotyrosine and 3-phosphoinositides
 1596
 0.47
chr18_21264983_21265134 0.31 LAMA3
 laminin, alpha 3
 4349
 0.25
chr18_67960362_67960513 0.31 SOCS6
 suppressor of cytokine signaling 6
 3398
 0.3
chr2_40078902_40079211 0.31 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 65463
 0.13
chr12_96769647_96769798 0.30 CDK17
 cyclin-dependent kinase 17
 23420
 0.18
chr2_145276293_145276624 0.30 ZEB2-AS1
 ZEB2 antisense RNA 1
 434
 0.52
chr6_41042761_41042912 0.30 NFYA
 nuclear transcription factor Y, alpha
 2114
 0.2
chr2_182758331_182758678 0.30 SSFA2
 sperm specific antigen 2
 1581
 0.37
chr1_200375128_200376098 0.29 ZNF281
 zinc finger protein 281
 3507
 0.37
chr19_30436184_30436558 0.29 URI1
 URI1, prefoldin-like chaperone
 2946
 0.39
chr6_144357186_144358268 0.29 PLAGL1
 pleiomorphic adenoma gene-like 1
 28008
 0.21
chr4_114214615_114214802 0.29 ANK2
 ankyrin 2, neuronal
 570
 0.85
chr7_120632569_120632731 0.29 CPED1
 cadherin-like and PC-esterase domain containing 1
 2974
 0.27
chr4_102542477_102542841 0.28 ENSG00000199529
 .
 102374
 0.08
chr15_23033242_23034084 0.28 NIPA2
 non imprinted in Prader-Willi/Angelman syndrome 2
 707
 0.67
chrX_124279731_124279882 0.28 ENSG00000263886
 .
 141819
 0.05
chr4_47489411_47489562 0.28 ATP10D
 ATPase, class V, type 10D
 2170
 0.34
chr8_54624701_54625055 0.27 ATP6V1H
 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
 127643
 0.05
chr11_84633973_84634163 0.27 DLG2
 discs, large homolog 2 (Drosophila)
 156
 0.97
chr19_6103077_6103270 0.27 CTB-66B24.1
6160
 0.15
chr19_54974999_54975150 0.27 LENG9
 leukocyte receptor cluster (LRC) member 9
 180
 0.88
chr2_102574409_102574560 0.27 IL1R2
 interleukin 1 receptor, type II
 33822
 0.19
chr15_73302646_73302797 0.27 NEO1
 neogenin 1
 41330
 0.2
chr2_223724916_223725067 0.27 ACSL3
 acyl-CoA synthetase long-chain family member 3
 661
 0.77
chr4_99444037_99444307 0.27 RP11-724M22.1
26657
 0.24
chr13_25034007_25034158 0.26 TPTE2P6
 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6
 51787
 0.12
chr3_25471806_25472309 0.26 RARB
 retinoic acid receptor, beta
 2255
 0.41
chr7_7196815_7197697 0.26 C1GALT1
 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
 691
 0.7
chr11_130305065_130305271 0.26 ADAMTS8
 ADAM metallopeptidase with thrombospondin type 1 motif, 8
 6280
 0.24
chr3_119808572_119808744 0.26 GSK3B
 glycogen synthase kinase 3 beta
 3855
 0.24
chrX_46442901_46443074 0.26 CHST7
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
 9768
 0.23
chr15_36231470_36231621 0.26 ENSG00000265098
 .
 12488
 0.32
chr5_66311217_66311678 0.26 MAST4
 microtubule associated serine/threonine kinase family member 4
 10964
 0.24
chr12_76424698_76425269 0.26 PHLDA1
 pleckstrin homology-like domain, family A, member 1
 401
 0.66
chr7_38923632_38923783 0.26 VPS41
 vacuolar protein sorting 41 homolog (S. cerevisiae)
 25067
 0.24
chr20_12989594_12990369 0.25 SPTLC3
 serine palmitoyltransferase, long chain base subunit 3
 16
 0.99
chr20_42377284_42377435 0.25 GTSF1L
 gametocyte specific factor 1-like
 21721
 0.2
chr1_186156970_186157465 0.25 GS1-174L6.4
10783
 0.22
chr11_125497097_125497248 0.25 CHEK1
 checkpoint kinase 1
 529
 0.7
chr6_132271007_132271170 0.25 RP11-69I8.3
998
 0.48
chr13_45620875_45621062 0.25 ENSG00000223341
 .
 13896
 0.16
chr2_189840264_189840425 0.25 COL3A1
 collagen, type III, alpha 1
 1245
 0.47
chr7_45958576_45958727 0.25 IGFBP3
 insulin-like growth factor binding protein 3
 1626
 0.39
chr1_163039219_163039545 0.25 RGS4
 regulator of G-protein signaling 4
 231
 0.96
chr1_198602543_198602694 0.25 PTPRC
 protein tyrosine phosphatase, receptor type, C
 5183
 0.27
chr3_171475362_171475648 0.25 PLD1
 phospholipase D1, phosphatidylcholine-specific
 13644
 0.22
chr19_3098811_3099227 0.25 GNA11
 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
 4611
 0.13
chr5_77797581_77797732 0.24 LHFPL2
 lipoma HMGIC fusion partner-like 2
 47318
 0.18
chr11_114166754_114166905 0.24 NNMT
 nicotinamide N-methyltransferase
 282
 0.93
chr6_79878048_79878303 0.24 HMGN3-AS1
 HMGN3 antisense RNA 1
 65260
 0.11
chr4_170190845_170191352 0.24 SH3RF1
 SH3 domain containing ring finger 1
 10
 0.99
chr15_83951840_83952048 0.24 BNC1
 basonuclin 1
 127
 0.97
chr17_16931289_16931440 0.23 MPRIP
 myosin phosphatase Rho interacting protein
 14495
 0.18
chr9_92151090_92151365 0.23 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 38182
 0.17
chr8_104312759_104312910 0.23 FZD6
 frizzled family receptor 6
 1730
 0.28
chr12_115130761_115130970 0.23 TBX3
 T-box 3
 8896
 0.23
chr14_56666447_56666727 0.23 PELI2
 pellino E3 ubiquitin protein ligase family member 2
 80760
 0.1
chr11_130030115_130030717 0.23 ST14
 suppression of tumorigenicity 14 (colon carcinoma)
 959
 0.66
chr2_65614657_65614911 0.23 AC012370.2
6965
 0.23
chr7_38576145_38576296 0.23 ENSG00000241756
 .
 5281
 0.31
chr9_75767359_75768171 0.23 ANXA1
 annexin A1
 947
 0.7
chr3_168865162_168865471 0.23 MECOM
 MDS1 and EVI1 complex locus
 206
 0.97
chr2_130515835_130516332 0.23 AC079776.2
167215
 0.03
chr3_172280513_172281223 0.23 TNFSF10
 tumor necrosis factor (ligand) superfamily, member 10
 39571
 0.16
chr5_140938191_140938342 0.23 CTD-2024I7.13
388
 0.78
chr12_22807162_22807313 0.23 ETNK1
 ethanolamine kinase 1
 28946
 0.2
chr3_45052751_45053653 0.23 CLEC3B
 C-type lectin domain family 3, member B
 14473
 0.15
chr12_124453376_124453888 0.23 RP11-214K3.20
506
 0.49
chr7_7736253_7736544 0.22 RPA3
 replication protein A3, 14kDa
 21840
 0.23
chr1_109933756_109933959 0.22 SORT1
 sortilin 1
 2122
 0.27
chr12_42630813_42630964 0.22 YAF2
 YY1 associated factor 2
 714
 0.52
chr12_62381215_62381366 0.22 FAM19A2
 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
 117419
 0.06
chrX_133682102_133682606 0.22 ENSG00000223749
 .
 1613
 0.22
chr9_91924793_91925270 0.22 CKS2
 CDC28 protein kinase regulatory subunit 2
 1082
 0.45
chr7_41426318_41426600 0.22 INHBA-AS1
 INHBA antisense RNA 1
 307055
 0.01
chr2_107082072_107082277 0.22 RGPD3
 RANBP2-like and GRIP domain containing 3
 2652
 0.28
chr3_133967997_133968801 0.22 RYK
 receptor-like tyrosine kinase
 1038
 0.66
chr3_149301834_149301985 0.21 WWTR1
 WW domain containing transcription regulator 1
 7870
 0.21
chr6_141587373_141587724 0.21 ENSG00000222764
 .
 220001
 0.02
chr3_194205911_194206797 0.21 ATP13A3
 ATPase type 13A3
 1034
 0.42
chr18_65929417_65929568 0.21 TMX3
 thioredoxin-related transmembrane protein 3
 452802
 0.01
chr17_7491050_7491201 0.21 SOX15
 SRY (sex determining region Y)-box 15
 2265
 0.08
chr8_116670939_116671090 0.21 TRPS1
 trichorhinophalangeal syndrome I
 2891
 0.42
chr1_100817332_100817558 0.21 CDC14A
 cell division cycle 14A
 155
 0.96
chr8_28861777_28861928 0.21 HMBOX1
 homeobox containing 1
 40472
 0.11
chr2_216691555_216691736 0.21 ENSG00000212055
 .
 51997
 0.17
chr16_68123462_68123613 0.21 ENSG00000201850
 .
 91
 0.94
chr15_92415930_92416081 0.21 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 18654
 0.24
chr7_80547175_80548098 0.21 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 863
 0.76
chr6_2377522_2377693 0.21 ENSG00000266252
 .
 32262
 0.24
chr11_61890885_61891204 0.21 INCENP
 inner centromere protein antigens 135/155kDa
 401
 0.85
chr5_130175429_130175580 0.21 HINT1
 histidine triad nucleotide binding protein 1
 322816
 0.01
chr18_73180620_73180771 0.21 SMIM21
 small integral membrane protein 21
 41037
 0.19
chr6_42537305_42537764 0.21 UBR2
 ubiquitin protein ligase E3 component n-recognin 2
 5734
 0.24
chr10_10953235_10953446 0.20 CELF2
 CUGBP, Elav-like family member 2
 93919
 0.08
chr6_138975748_138976299 0.20 RP11-390P2.4
37662
 0.17
chr8_16689434_16690090 0.20 ENSG00000264092
 .
 31243
 0.24
chr2_178029566_178030097 0.20 ENSG00000251746
 .
 26404
 0.12
chr4_83810146_83810528 0.20 SEC31A
 SEC31 homolog A (S. cerevisiae)
 1834
 0.28
chr15_59939623_59939774 0.20 GTF2A2
 general transcription factor IIA, 2, 12kDa
 9980
 0.14
chr5_12989682_12989833 0.20 ENSG00000222717
 .
 185203
 0.03
chr1_72587992_72588143 0.20 NEGR1
 neuronal growth regulator 1
 21454
 0.29
chr2_147579520_147579813 0.20 ENSG00000238860
 .
 501873
 0.0
chr5_126182453_126182725 0.20 LMNB1
 lamin B1
 69708
 0.11
chr10_1100415_1100678 0.20 WDR37
 WD repeat domain 37
 1798
 0.26
chr13_80059310_80059736 0.20 NDFIP2
 Nedd4 family interacting protein 2
 3935
 0.24
chr13_75466251_75466402 0.20 ENSG00000206812
 .
 217398
 0.02
chr16_10646719_10646878 0.20 EMP2
 epithelial membrane protein 2
 6213
 0.18
chr6_21506218_21506369 0.20 SOX4
 SRY (sex determining region Y)-box 4
 87679
 0.11
chr20_35830256_35830797 0.20 MROH8
 maestro heat-like repeat family member 8
 22535
 0.17
chr20_52407623_52407774 0.19 ENSG00000238468
 .
 122401
 0.05
chr3_184036946_184037180 0.19 EIF4G1
 eukaryotic translation initiation factor 4 gamma, 1
 76
 0.94
chr14_71838887_71839322 0.19 ENSG00000207444
 .
 25950
 0.19
chr2_160569559_160570270 0.19 MARCH7
 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
 896
 0.68
chr5_121424700_121424851 0.19 LOX
 lysyl oxidase
 10795
 0.21
chr15_57511580_57511963 0.19 TCF12
 transcription factor 12
 107
 0.98
chr2_232646427_232646801 0.19 COPS7B
 COP9 signalosome subunit 7B
 219
 0.79
chr2_187354223_187354374 0.19 ZC3H15
 zinc finger CCCH-type containing 15
 3318
 0.24
chr6_47381977_47382964 0.19 ENSG00000266330
 .
 48182
 0.14
chr3_139175617_139175768 0.19 RP11-319G6.3
9580
 0.15
chr5_53303962_53304113 0.19 ENSG00000241230
 .
 40101
 0.16
chr9_12718902_12719101 0.19 TYRP1
 tyrosinase-related protein 1
 23281
 0.2
chr4_114880734_114880959 0.19 RP11-26P13.2
16434
 0.24
chr7_116229019_116229170 0.19 AC006159.4
17806
 0.18
chr21_33613293_33613449 0.19 MIS18A-AS1
 MIS18A antisense RNA 1
 36803
 0.12
chr8_130742298_130742449 0.19 GSDMC
 gasdermin C
 56761
 0.14
chr6_121756849_121757212 0.19 GJA1
 gap junction protein, alpha 1, 43kDa
 192
 0.94
chr9_92724401_92724683 0.19 ENSG00000263967
 .
 61275
 0.16
chr16_79758893_79759044 0.19 ENSG00000221330
 .
 55334
 0.17
chr3_42888617_42888768 0.18 ACKR2
 atypical chemokine receptor 2
 3236
 0.16
chr2_85778069_85778220 0.18 GGCX
 gamma-glutamyl carboxylase
 10488
 0.09
chr7_23518547_23518698 0.18 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 8536
 0.17
chr4_26347600_26347761 0.18 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 2918
 0.4
chr19_12061488_12061639 0.18 ZNF700
 zinc finger protein 700
 3994
 0.13
chr10_124066979_124067204 0.18 BTBD16
 BTB (POZ) domain containing 16
 36270
 0.14
chr4_148009310_148009488 0.18 TTC29
 tetratricopeptide repeat domain 29
 142365
 0.05
chr1_32168571_32169014 0.18 COL16A1
 collagen, type XVI, alpha 1
 976
 0.48
chr12_5540873_5541141 0.18 NTF3
 neurotrophin 3
 272
 0.96
chr2_145269652_145269839 0.18 ZEB2
 zinc finger E-box binding homeobox 2
 5370
 0.26
chr19_4402073_4402293 0.18 CHAF1A
 chromatin assembly factor 1, subunit A (p150)
 476
 0.58
chr12_92541063_92541214 0.18 RP11-796E2.4
1181
 0.36
chr2_150782681_150782948 0.18 ENSG00000207270
 .
 315526
 0.01
chr22_30485175_30485353 0.18 HORMAD2
 HORMA domain containing 2
 8264
 0.18
chr12_104226819_104227112 0.18 NT5DC3
 5'-nucleotidase domain containing 3
 8010
 0.15
chr21_16431010_16431483 0.18 NRIP1
 nuclear receptor interacting protein 1
 5880
 0.3
chr1_226791109_226791285 0.18 C1orf95
 chromosome 1 open reading frame 95
 54696
 0.12
chr2_155795915_155796066 0.18 ENSG00000223197
 .
 150060
 0.04
chrX_130917856_130918233 0.18 ENSG00000200587
 .
 154940
 0.04
chr10_13491532_13491683 0.18 BEND7
 BEN domain containing 7
 31466
 0.14
chr3_170893303_170893462 0.18 TNIK
 TRAF2 and NCK interacting kinase
 50118
 0.15
chr1_224373491_224373642 0.18 DEGS1
 delta(4)-desaturase, sphingolipid 1
 2598
 0.21
chr4_186696107_186696537 0.17 SORBS2
 sorbin and SH3 domain containing 2
 108
 0.98
chr9_112814566_112814717 0.17 AKAP2
 A kinase (PRKA) anchor protein 2
 3665
 0.35

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.3 GO:0043206 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.1 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.3 GO:0060039 pericardium development(GO:0060039)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.1 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.1 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.2 GO:0021781 glial cell fate commitment(GO:0021781)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0007100 mitotic centrosome separation(GO:0007100)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.1 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0016556 mRNA modification(GO:0016556)
0.0 0.0 GO:0021825 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.3 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.1 GO:1903020 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.0 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.0 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 0.0 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.0 GO:0001757 somite specification(GO:0001757)
0.0 0.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.0 GO:0016093 polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0 0.0 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.0 GO:0046606 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0042640 anagen(GO:0042640)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031211 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.0 GO:0034711 inhibin binding(GO:0034711)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.1 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.1 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME CELL CELL COMMUNICATION Genes involved in Cell-Cell communication