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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for IRX6_IRX4

Z-value: 1.00

Motif logo

Transcription factors associated with IRX6_IRX4

Gene Symbol	Gene ID	Gene Info
IRX6 Ensembl NCBI GeneCards UniProt	ENSG00000159387.7	IRX6
IRX4 Ensembl NCBI GeneCards UniProt	ENSG00000113430.5	IRX4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
IRX4	chr5_1887316_1887467	41	0.506685	0.56	1.2e-01	Click!
IRX4	chr5_1879697_1879902	3059	0.199626	0.53	1.4e-01	Click!
IRX4	chr5_1886065_1886216	1192	0.310660	0.44	2.4e-01	Click!
IRX4	chr5_1882927_1883078	122	0.926819	0.34	3.7e-01	Click!
IRX4	chr5_1886412_1886563	845	0.392112	0.32	4.0e-01	Click!
IRX6	chr16_55361576_55361727	3979	0.225858	0.55	1.2e-01	Click!
IRX6	chr16_55358539_55358690	942	0.579550	0.55	1.3e-01	Click!
IRX6	chr16_55359549_55359700	1952	0.334397	0.48	1.9e-01	Click!
IRX6	chr16_55358328_55358505	744	0.671458	0.26	4.9e-01	Click!
IRX6	chr16_55358802_55358953	1205	0.484201	0.26	5.0e-01	Click!

Activity of the IRX6_IRX4 motif across conditions

Conditions sorted by the z-value of the IRX6_IRX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_150779976_150780304	0.66	CTSK	cathepsin K	230	0.9
chr14_81789363_81789514	0.56	STON2	stonin 2	46161	0.18
chr2_166031255_166031406	0.52	SCN3A	sodium channel, voltage-gated, type III, alpha subunit	11734	0.22
chr6_56414295_56414544	0.52	DST	dystonin	75631	0.11
chr7_117720696_117720847	0.52	NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit	103315	0.08
chr10_21688030_21688514	0.50	ENSG00000207264	.	77382	0.08
chr12_13351250_13351500	0.50	EMP1	epithelial membrane protein 1	1655	0.47
chr2_173686973_173687124	0.49	RAPGEF4	Rap guanine nucleotide exchange factor (GEF) 4	745	0.77
chr2_189834539_189834690	0.49	COL3A1	collagen, type III, alpha 1	4432	0.25
chr20_15680912_15681288	0.46	ENSG00000212111	.	141987	0.05
chr10_52687623_52687774	0.45	A1CF	APOBEC1 complementation factor	42263	0.16
chr10_29879098_29879625	0.44	ENSG00000216035	.	11914	0.18
chr3_99360396_99360669	0.43	COL8A1	collagen, type VIII, alpha 1	3078	0.35
chr12_42982187_42982354	0.43	PRICKLE1	prickle homolog 1 (Drosophila)	1208	0.6
chr4_187491209_187491867	0.42	MTNR1A	melatonin receptor 1A	14817	0.17
chr3_71295420_71295571	0.41	FOXP1	forkhead box P1	1179	0.61
chr3_63748246_63748457	0.40	AC136289.1		42418	0.14
chr8_30278844_30278995	0.40	RBPMS	RNA binding protein with multiple splicing	21214	0.21
chr1_197167655_197168814	0.40	ZBTB41	zinc finger and BTB domain containing 41	1438	0.4
chr1_57661483_57661634	0.40	DAB1	Dab, reelin signal transducer, homolog 1 (Drosophila)	95179	0.09
chr11_121969171_121969347	0.40	ENSG00000207971	.	1293	0.36
chr4_170189564_170189726	0.39	SH3RF1	SH3 domain containing ring finger 1	1463	0.54
chr19_16179581_16179939	0.38	TPM4	tropomyosin 4	1250	0.44
chr7_42228970_42229243	0.38	GLI3	GLI family zinc finger 3	38214	0.24
chr6_80248235_80248430	0.38	LCA5	Leber congenital amaurosis 5	1157	0.64
chr7_116483846_116484032	0.37	CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	18588	0.19
chr1_69950952_69951103	0.36	LRRC7	leucine rich repeat containing 7	83054	0.11
chr1_24739398_24739744	0.36	STPG1	sperm-tail PG-rich repeat containing 1	644	0.68
chr3_98617426_98617589	0.36	DCBLD2	discoidin, CUB and LCCL domain containing 2	2508	0.26
chr9_139684873_139685024	0.36	TMEM141	transmembrane protein 141	859	0.25
chr2_64017838_64018067	0.36	UGP2	UDP-glucose pyrophosphorylase 2	50122	0.16
chr11_8830627_8830889	0.35	ST5	suppression of tumorigenicity 5	1438	0.35
chr2_9398911_9399239	0.35	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	52181	0.16
chr5_16549957_16550209	0.35	FAM134B	family with sequence similarity 134, member B	40976	0.15
chr9_110247534_110247685	0.35	KLF4	Kruppel-like factor 4 (gut)	3802	0.26
chr6_73262911_73263125	0.35	KCNQ5	potassium voltage-gated channel, KQT-like subfamily, member 5	68502	0.12
chr4_177701020_177701171	0.34	VEGFC	vascular endothelial growth factor C	12786	0.3
chr16_49686685_49686863	0.34	ZNF423	zinc finger protein 423	11362	0.24
chr2_178196983_178197134	0.34	AC074286.1		9166	0.12
chr12_76271592_76272084	0.33	ENSG00000243420	.	80072	0.1
chr14_64389363_64389514	0.33	SYNE2	spectrin repeat containing, nuclear envelope 2	13622	0.25
chr2_120064088_120064263	0.33	STEAP3-AS1	STEAP3 antisense RNA 1	57528	0.1
chr15_71035707_71036127	0.33	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	19852	0.21
chr1_192775406_192775557	0.33	RGS2	regulator of G-protein signaling 2, 24kDa	2690	0.37
chr4_47488156_47488587	0.32	ATP10D	ATPase, class V, type 10D	1055	0.56
chr1_33497639_33497820	0.32	AK2	adenylate kinase 2	4712	0.19
chr2_10036128_10036279	0.32	TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	20076	0.2
chr4_100739524_100739675	0.32	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	1596	0.47
chr18_21264983_21265134	0.31	LAMA3	laminin, alpha 3	4349	0.25
chr18_67960362_67960513	0.31	SOCS6	suppressor of cytokine signaling 6	3398	0.3
chr2_40078902_40079211	0.31	SLC8A1-AS1	SLC8A1 antisense RNA 1	65463	0.13
chr12_96769647_96769798	0.30	CDK17	cyclin-dependent kinase 17	23420	0.18
chr2_145276293_145276624	0.30	ZEB2-AS1	ZEB2 antisense RNA 1	434	0.52
chr6_41042761_41042912	0.30	NFYA	nuclear transcription factor Y, alpha	2114	0.2
chr2_182758331_182758678	0.30	SSFA2	sperm specific antigen 2	1581	0.37
chr1_200375128_200376098	0.29	ZNF281	zinc finger protein 281	3507	0.37
chr19_30436184_30436558	0.29	URI1	URI1, prefoldin-like chaperone	2946	0.39
chr6_144357186_144358268	0.29	PLAGL1	pleiomorphic adenoma gene-like 1	28008	0.21
chr4_114214615_114214802	0.29	ANK2	ankyrin 2, neuronal	570	0.85
chr7_120632569_120632731	0.29	CPED1	cadherin-like and PC-esterase domain containing 1	2974	0.27
chr4_102542477_102542841	0.28	ENSG00000199529	.	102374	0.08
chr15_23033242_23034084	0.28	NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	707	0.67
chrX_124279731_124279882	0.28	ENSG00000263886	.	141819	0.05
chr4_47489411_47489562	0.28	ATP10D	ATPase, class V, type 10D	2170	0.34
chr8_54624701_54625055	0.27	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	127643	0.05
chr11_84633973_84634163	0.27	DLG2	discs, large homolog 2 (Drosophila)	156	0.97
chr19_6103077_6103270	0.27	CTB-66B24.1		6160	0.15
chr19_54974999_54975150	0.27	LENG9	leukocyte receptor cluster (LRC) member 9	180	0.88
chr2_102574409_102574560	0.27	IL1R2	interleukin 1 receptor, type II	33822	0.19
chr15_73302646_73302797	0.27	NEO1	neogenin 1	41330	0.2
chr2_223724916_223725067	0.27	ACSL3	acyl-CoA synthetase long-chain family member 3	661	0.77
chr4_99444037_99444307	0.27	RP11-724M22.1		26657	0.24
chr13_25034007_25034158	0.26	TPTE2P6	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6	51787	0.12
chr3_25471806_25472309	0.26	RARB	retinoic acid receptor, beta	2255	0.41
chr7_7196815_7197697	0.26	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	691	0.7
chr11_130305065_130305271	0.26	ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8	6280	0.24
chr3_119808572_119808744	0.26	GSK3B	glycogen synthase kinase 3 beta	3855	0.24
chrX_46442901_46443074	0.26	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	9768	0.23
chr15_36231470_36231621	0.26	ENSG00000265098	.	12488	0.32
chr5_66311217_66311678	0.26	MAST4	microtubule associated serine/threonine kinase family member 4	10964	0.24
chr12_76424698_76425269	0.26	PHLDA1	pleckstrin homology-like domain, family A, member 1	401	0.66
chr7_38923632_38923783	0.26	VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	25067	0.24
chr20_12989594_12990369	0.25	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	16	0.99
chr20_42377284_42377435	0.25	GTSF1L	gametocyte specific factor 1-like	21721	0.2
chr1_186156970_186157465	0.25	GS1-174L6.4		10783	0.22
chr11_125497097_125497248	0.25	CHEK1	checkpoint kinase 1	529	0.7
chr6_132271007_132271170	0.25	RP11-69I8.3		998	0.48
chr13_45620875_45621062	0.25	ENSG00000223341	.	13896	0.16
chr2_189840264_189840425	0.25	COL3A1	collagen, type III, alpha 1	1245	0.47
chr7_45958576_45958727	0.25	IGFBP3	insulin-like growth factor binding protein 3	1626	0.39
chr1_163039219_163039545	0.25	RGS4	regulator of G-protein signaling 4	231	0.96
chr1_198602543_198602694	0.25	PTPRC	protein tyrosine phosphatase, receptor type, C	5183	0.27
chr3_171475362_171475648	0.25	PLD1	phospholipase D1, phosphatidylcholine-specific	13644	0.22
chr19_3098811_3099227	0.25	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	4611	0.13
chr5_77797581_77797732	0.24	LHFPL2	lipoma HMGIC fusion partner-like 2	47318	0.18
chr11_114166754_114166905	0.24	NNMT	nicotinamide N-methyltransferase	282	0.93
chr6_79878048_79878303	0.24	HMGN3-AS1	HMGN3 antisense RNA 1	65260	0.11
chr4_170190845_170191352	0.24	SH3RF1	SH3 domain containing ring finger 1	10	0.99
chr15_83951840_83952048	0.24	BNC1	basonuclin 1	127	0.97
chr17_16931289_16931440	0.23	MPRIP	myosin phosphatase Rho interacting protein	14495	0.18
chr9_92151090_92151365	0.23	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	38182	0.17
chr8_104312759_104312910	0.23	FZD6	frizzled family receptor 6	1730	0.28
chr12_115130761_115130970	0.23	TBX3	T-box 3	8896	0.23
chr14_56666447_56666727	0.23	PELI2	pellino E3 ubiquitin protein ligase family member 2	80760	0.1
chr11_130030115_130030717	0.23	ST14	suppression of tumorigenicity 14 (colon carcinoma)	959	0.66
chr2_65614657_65614911	0.23	AC012370.2		6965	0.23
chr7_38576145_38576296	0.23	ENSG00000241756	.	5281	0.31
chr9_75767359_75768171	0.23	ANXA1	annexin A1	947	0.7
chr3_168865162_168865471	0.23	MECOM	MDS1 and EVI1 complex locus	206	0.97
chr2_130515835_130516332	0.23	AC079776.2		167215	0.03
chr3_172280513_172281223	0.23	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	39571	0.16
chr5_140938191_140938342	0.23	CTD-2024I7.13		388	0.78
chr12_22807162_22807313	0.23	ETNK1	ethanolamine kinase 1	28946	0.2
chr3_45052751_45053653	0.23	CLEC3B	C-type lectin domain family 3, member B	14473	0.15
chr12_124453376_124453888	0.23	RP11-214K3.20		506	0.49
chr7_7736253_7736544	0.22	RPA3	replication protein A3, 14kDa	21840	0.23
chr1_109933756_109933959	0.22	SORT1	sortilin 1	2122	0.27
chr12_42630813_42630964	0.22	YAF2	YY1 associated factor 2	714	0.52
chr12_62381215_62381366	0.22	FAM19A2	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	117419	0.06
chrX_133682102_133682606	0.22	ENSG00000223749	.	1613	0.22
chr9_91924793_91925270	0.22	CKS2	CDC28 protein kinase regulatory subunit 2	1082	0.45
chr7_41426318_41426600	0.22	INHBA-AS1	INHBA antisense RNA 1	307055	0.01
chr2_107082072_107082277	0.22	RGPD3	RANBP2-like and GRIP domain containing 3	2652	0.28
chr3_133967997_133968801	0.22	RYK	receptor-like tyrosine kinase	1038	0.66
chr3_149301834_149301985	0.21	WWTR1	WW domain containing transcription regulator 1	7870	0.21
chr6_141587373_141587724	0.21	ENSG00000222764	.	220001	0.02
chr3_194205911_194206797	0.21	ATP13A3	ATPase type 13A3	1034	0.42
chr18_65929417_65929568	0.21	TMX3	thioredoxin-related transmembrane protein 3	452802	0.01
chr17_7491050_7491201	0.21	SOX15	SRY (sex determining region Y)-box 15	2265	0.08
chr8_116670939_116671090	0.21	TRPS1	trichorhinophalangeal syndrome I	2891	0.42
chr1_100817332_100817558	0.21	CDC14A	cell division cycle 14A	155	0.96
chr8_28861777_28861928	0.21	HMBOX1	homeobox containing 1	40472	0.11
chr2_216691555_216691736	0.21	ENSG00000212055	.	51997	0.17
chr16_68123462_68123613	0.21	ENSG00000201850	.	91	0.94
chr15_92415930_92416081	0.21	SLCO3A1	solute carrier organic anion transporter family, member 3A1	18654	0.24
chr7_80547175_80548098	0.21	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	863	0.76
chr6_2377522_2377693	0.21	ENSG00000266252	.	32262	0.24
chr11_61890885_61891204	0.21	INCENP	inner centromere protein antigens 135/155kDa	401	0.85
chr5_130175429_130175580	0.21	HINT1	histidine triad nucleotide binding protein 1	322816	0.01
chr18_73180620_73180771	0.21	SMIM21	small integral membrane protein 21	41037	0.19
chr6_42537305_42537764	0.21	UBR2	ubiquitin protein ligase E3 component n-recognin 2	5734	0.24
chr10_10953235_10953446	0.20	CELF2	CUGBP, Elav-like family member 2	93919	0.08
chr6_138975748_138976299	0.20	RP11-390P2.4		37662	0.17
chr8_16689434_16690090	0.20	ENSG00000264092	.	31243	0.24
chr2_178029566_178030097	0.20	ENSG00000251746	.	26404	0.12
chr4_83810146_83810528	0.20	SEC31A	SEC31 homolog A (S. cerevisiae)	1834	0.28
chr15_59939623_59939774	0.20	GTF2A2	general transcription factor IIA, 2, 12kDa	9980	0.14
chr5_12989682_12989833	0.20	ENSG00000222717	.	185203	0.03
chr1_72587992_72588143	0.20	NEGR1	neuronal growth regulator 1	21454	0.29
chr2_147579520_147579813	0.20	ENSG00000238860	.	501873	0.0
chr5_126182453_126182725	0.20	LMNB1	lamin B1	69708	0.11
chr10_1100415_1100678	0.20	WDR37	WD repeat domain 37	1798	0.26
chr13_80059310_80059736	0.20	NDFIP2	Nedd4 family interacting protein 2	3935	0.24
chr13_75466251_75466402	0.20	ENSG00000206812	.	217398	0.02
chr16_10646719_10646878	0.20	EMP2	epithelial membrane protein 2	6213	0.18
chr6_21506218_21506369	0.20	SOX4	SRY (sex determining region Y)-box 4	87679	0.11
chr20_35830256_35830797	0.20	MROH8	maestro heat-like repeat family member 8	22535	0.17
chr20_52407623_52407774	0.19	ENSG00000238468	.	122401	0.05
chr3_184036946_184037180	0.19	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	76	0.94
chr14_71838887_71839322	0.19	ENSG00000207444	.	25950	0.19
chr2_160569559_160570270	0.19	MARCH7	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	896	0.68
chr5_121424700_121424851	0.19	LOX	lysyl oxidase	10795	0.21
chr15_57511580_57511963	0.19	TCF12	transcription factor 12	107	0.98
chr2_232646427_232646801	0.19	COPS7B	COP9 signalosome subunit 7B	219	0.79
chr2_187354223_187354374	0.19	ZC3H15	zinc finger CCCH-type containing 15	3318	0.24
chr6_47381977_47382964	0.19	ENSG00000266330	.	48182	0.14
chr3_139175617_139175768	0.19	RP11-319G6.3		9580	0.15
chr5_53303962_53304113	0.19	ENSG00000241230	.	40101	0.16
chr9_12718902_12719101	0.19	TYRP1	tyrosinase-related protein 1	23281	0.2
chr4_114880734_114880959	0.19	RP11-26P13.2		16434	0.24
chr7_116229019_116229170	0.19	AC006159.4		17806	0.18
chr21_33613293_33613449	0.19	MIS18A-AS1	MIS18A antisense RNA 1	36803	0.12
chr8_130742298_130742449	0.19	GSDMC	gasdermin C	56761	0.14
chr6_121756849_121757212	0.19	GJA1	gap junction protein, alpha 1, 43kDa	192	0.94
chr9_92724401_92724683	0.19	ENSG00000263967	.	61275	0.16
chr16_79758893_79759044	0.19	ENSG00000221330	.	55334	0.17
chr3_42888617_42888768	0.18	ACKR2	atypical chemokine receptor 2	3236	0.16
chr2_85778069_85778220	0.18	GGCX	gamma-glutamyl carboxylase	10488	0.09
chr7_23518547_23518698	0.18	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	8536	0.17
chr4_26347600_26347761	0.18	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	2918	0.4
chr19_12061488_12061639	0.18	ZNF700	zinc finger protein 700	3994	0.13
chr10_124066979_124067204	0.18	BTBD16	BTB (POZ) domain containing 16	36270	0.14
chr4_148009310_148009488	0.18	TTC29	tetratricopeptide repeat domain 29	142365	0.05
chr1_32168571_32169014	0.18	COL16A1	collagen, type XVI, alpha 1	976	0.48
chr12_5540873_5541141	0.18	NTF3	neurotrophin 3	272	0.96
chr2_145269652_145269839	0.18	ZEB2	zinc finger E-box binding homeobox 2	5370	0.26
chr19_4402073_4402293	0.18	CHAF1A	chromatin assembly factor 1, subunit A (p150)	476	0.58
chr12_92541063_92541214	0.18	RP11-796E2.4		1181	0.36
chr2_150782681_150782948	0.18	ENSG00000207270	.	315526	0.01
chr22_30485175_30485353	0.18	HORMAD2	HORMA domain containing 2	8264	0.18
chr12_104226819_104227112	0.18	NT5DC3	5'-nucleotidase domain containing 3	8010	0.15
chr21_16431010_16431483	0.18	NRIP1	nuclear receptor interacting protein 1	5880	0.3
chr1_226791109_226791285	0.18	C1orf95	chromosome 1 open reading frame 95	54696	0.12
chr2_155795915_155796066	0.18	ENSG00000223197	.	150060	0.04
chrX_130917856_130918233	0.18	ENSG00000200587	.	154940	0.04
chr10_13491532_13491683	0.18	BEND7	BEN domain containing 7	31466	0.14
chr3_170893303_170893462	0.18	TNIK	TRAF2 and NCK interacting kinase	50118	0.15
chr1_224373491_224373642	0.18	DEGS1	delta(4)-desaturase, sphingolipid 1	2598	0.21
chr4_186696107_186696537	0.17	SORBS2	sorbin and SH3 domain containing 2	108	0.98
chr9_112814566_112814717	0.17	AKAP2	A kinase (PRKA) anchor protein 2	3665	0.35

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.2	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.1	0.2	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.1	0.2	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.2	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.2	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.3	GO:0043206	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.2	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.3	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.1	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.2	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.2	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.1	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0006531	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.0	GO:0021825	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.3	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.0	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:1903020	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.0	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.0	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.0	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0042640	anagen(GO:0042640)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	0.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.2	GO:0000801	central element(GO:0000801)
0.0	0.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.2	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.5	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	0.2	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.2	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.4	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.3	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.0	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.0	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0016408	C-acyltransferase activity(GO:0016408)
0.0	0.1	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.2	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.7	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.2	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.3	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME CELL CELL COMMUNICATION	Genes involved in Cell-Cell communication