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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ISL2

Z-value: 0.93

Motif logo

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
ISL2chr15_76628683_766288343070.900622-0.646.3e-02Click!
ISL2chr15_76627931_766285838080.638054-0.501.7e-01Click!
ISL2chr15_76629589_766297636110.737067-0.353.5e-01Click!
ISL2chr15_76630019_7663025410710.521373-0.274.8e-01Click!
ISL2chr15_76629117_766295102480.925541-0.245.4e-01Click!

Activity of the ISL2 motif across conditions

Conditions sorted by the z-value of the ISL2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr15_30112674_30113382 0.72 TJP1
 tight junction protein 1
 723
 0.64
chr6_28616143_28617086 0.60 ENSG00000272278
 .
 572
 0.79
chr10_29010987_29011704 0.59 ENSG00000201001
 .
 38387
 0.14
chr9_14312608_14313176 0.58 NFIB
 nuclear factor I/B
 774
 0.71
chr22_36231755_36232301 0.58 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 4237
 0.32
chr2_9348603_9349207 0.56 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 2011
 0.46
chr8_127837007_127837644 0.50 ENSG00000212451
 .
 153558
 0.04
chr10_18629419_18629841 0.50 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
 36
 0.99
chr20_14316163_14316462 0.50 FLRT3
 fibronectin leucine rich transmembrane protein 3
 1942
 0.4
chr4_41215270_41215769 0.49 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 956
 0.59
chr6_28641788_28642196 0.49 ENSG00000272278
 .
 25950
 0.18
chr9_97812256_97812766 0.49 ENSG00000207563
 .
 34979
 0.12
chr21_34918443_34918594 0.48 GART
 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
 2721
 0.18
chr1_225117686_225118141 0.48 DNAH14
 dynein, axonemal, heavy chain 14
 529
 0.87
chr13_93897456_93897607 0.48 GPC6
 glypican 6
 18436
 0.29
chr4_77611462_77611724 0.47 AC107072.2
52817
 0.12
chr11_131780111_131780399 0.47 NTM
 neurotrimin
 642
 0.77
chr8_116675050_116675578 0.46 TRPS1
 trichorhinophalangeal syndrome I
 1409
 0.6
chr1_95005421_95005705 0.44 F3
 coagulation factor III (thromboplastin, tissue factor)
 1630
 0.52
chr4_122686341_122686757 0.44 TMEM155
 transmembrane protein 155
 33
 0.94
chr15_49716998_49717158 0.44 FGF7
 fibroblast growth factor 7
 1621
 0.44
chr11_69454777_69455129 0.42 CCND1
 cyclin D1
 902
 0.63
chr8_38855409_38855789 0.42 ADAM9
 ADAM metallopeptidase domain 9
 1094
 0.34
chr3_149094469_149095370 0.41 TM4SF1-AS1
 TM4SF1 antisense RNA 1
 646
 0.47
chr2_200446222_200446758 0.41 SATB2
 SATB homeobox 2
 110501
 0.07
chr7_98970111_98970529 0.40 ARPC1B
 actin related protein 2/3 complex, subunit 1B, 41kDa
 1552
 0.28
chr12_75784171_75784441 0.39 CAPS2
 calcyphosine 2
 375
 0.6
chr6_169653692_169653887 0.39 THBS2
 thrombospondin 2
 350
 0.92
chr17_35851874_35852313 0.39 DUSP14
 dual specificity phosphatase 14
 523
 0.79
chr2_235861878_235862318 0.39 SH3BP4
 SH3-domain binding protein 4
 1378
 0.62
chr21_16431010_16431483 0.38 NRIP1
 nuclear receptor interacting protein 1
 5880
 0.3
chr20_35830256_35830797 0.38 MROH8
 maestro heat-like repeat family member 8
 22535
 0.17
chr3_132315920_132316071 0.37 ACKR4
 atypical chemokine receptor 4
 86
 0.98
chr21_39807445_39807798 0.37 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 62724
 0.14
chrX_73069883_73070423 0.36 RP13-216E22.5
119167
 0.06
chr15_59663421_59663716 0.36 FAM81A
 family with sequence similarity 81, member A
 1324
 0.28
chr1_185704392_185704588 0.36 HMCN1
 hemicentin 1
 807
 0.75
chr18_52495652_52496658 0.36 RAB27B
 RAB27B, member RAS oncogene family
 725
 0.77
chr3_157822422_157822707 0.35 SHOX2
 short stature homeobox 2
 519
 0.7
chr7_116141197_116141631 0.35 CAV2
 caveolin 2
 1580
 0.29
chr10_33620140_33620362 0.35 NRP1
 neuropilin 1
 3059
 0.34
chr7_80547175_80548098 0.35 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 863
 0.76
chr7_18550520_18550717 0.35 HDAC9
 histone deacetylase 9
 1682
 0.51
chr8_25868117_25868310 0.35 EBF2
 early B-cell factor 2
 30791
 0.24
chr12_78334931_78335200 0.35 NAV3
 neuron navigator 3
 24991
 0.28
chr6_56111778_56112295 0.35 COL21A1
 collagen, type XXI, alpha 1
 199
 0.97
chr1_99126586_99127126 0.35 SNX7
 sorting nexin 7
 380
 0.93
chrX_114795565_114796048 0.34 PLS3
 plastin 3
 224
 0.9
chr1_100111418_100111643 0.34 PALMD
 palmdelphin
 31
 0.99
chr12_26112779_26113361 0.34 RASSF8-AS1
 RASSF8 atnisense RNA 1
 372
 0.8
chr2_236410241_236410494 0.34 AGAP1-IT1
 AGAP1 intronic transcript 1 (non-protein coding)
 4028
 0.26
chr5_9540799_9541378 0.34 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 5099
 0.2
chr9_684288_685148 0.34 RP11-130C19.3
837
 0.67
chr10_69831641_69832005 0.34 HERC4
 HECT and RLD domain containing E3 ubiquitin protein ligase 4
 2071
 0.33
chr16_54407600_54408115 0.33 IRX3
 iroquois homeobox 3
 87182
 0.09
chr5_66311217_66311678 0.33 MAST4
 microtubule associated serine/threonine kinase family member 4
 10964
 0.24
chr7_28943782_28944337 0.33 CTB-113D17.1
75524
 0.1
chr1_45083000_45083241 0.32 RNF220
 ring finger protein 220
 8878
 0.17
chr13_24146066_24146217 0.32 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 1338
 0.59
chr18_60385543_60385694 0.31 PHLPP1
 PH domain and leucine rich repeat protein phosphatase 1
 2935
 0.28
chr3_33318777_33319866 0.31 FBXL2
 F-box and leucine-rich repeat protein 2
 353
 0.91
chr13_76217437_76217800 0.31 LMO7
 LIM domain 7
 7159
 0.18
chr21_17909068_17909746 0.31 ENSG00000207638
 .
 2002
 0.33
chr1_57041430_57041821 0.31 PPAP2B
 phosphatidic acid phosphatase type 2B
 3616
 0.34
chr8_30243504_30243875 0.31 RBPMS-AS1
 RBPMS antisense RNA 1
 772
 0.48
chr14_71067961_71068112 0.30 MED6
 mediator complex subunit 6
 652
 0.7
chr22_36310772_36312004 0.30 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 23557
 0.25
chr15_60683943_60684180 0.30 ANXA2
 annexin A2
 565
 0.83
chr10_4719640_4719886 0.30 AKR1E2
 aldo-keto reductase family 1, member E2
 109058
 0.07
chr13_38445031_38445182 0.30 TRPC4
 transient receptor potential cation channel, subfamily C, member 4
 544
 0.83
chr9_74510609_74510876 0.30 ENSG00000200922
 .
 6724
 0.2
chr17_33391542_33391948 0.30 RFFL
 ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
 874
 0.45
chr3_145876853_145877198 0.30 PLOD2
 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 1754
 0.42
chr14_45433796_45433989 0.30 FAM179B
 family with sequence similarity 179, member B
 2450
 0.23
chr11_89027115_89027763 0.30 TYR
 tyrosinase
 116819
 0.06
chr15_68574728_68574982 0.30 FEM1B
 fem-1 homolog b (C. elegans)
 2558
 0.28
chr8_38030618_38031135 0.30 BAG4
 BCL2-associated athanogene 4
 3230
 0.13
chr11_101983358_101983513 0.30 YAP1
 Yes-associated protein 1
 190
 0.94
chr8_87317262_87317629 0.29 WWP1
 WW domain containing E3 ubiquitin protein ligase 1
 37522
 0.18
chr1_178269315_178269642 0.29 RASAL2
 RAS protein activator like 2
 41128
 0.2
chr13_38172411_38172686 0.29 POSTN
 periostin, osteoblast specific factor
 315
 0.95
chr21_18376217_18376955 0.29 ENSG00000239023
 .
 285269
 0.01
chr1_230223080_230223231 0.29 GALNT2
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
 20137
 0.23
chr5_88178054_88178448 0.29 MEF2C
 myocyte enhancer factor 2C
 713
 0.52
chr11_133990232_133990720 0.29 NCAPD3
 non-SMC condensin II complex, subunit D3
 47891
 0.12
chr3_87036535_87037613 0.29 VGLL3
 vestigial like 3 (Drosophila)
 2778
 0.42
chr18_61554936_61555215 0.29 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
 82
 0.97
chr10_33620428_33620906 0.28 NRP1
 neuropilin 1
 2643
 0.37
chr10_5005306_5005493 0.28 AKR1C1
 aldo-keto reductase family 1, member C1
 46
 0.92
chr9_109625885_109626257 0.28 ZNF462
 zinc finger protein 462
 624
 0.77
chr15_96897591_96898313 0.28 AC087477.1
 Uncharacterized protein
 6535
 0.18
chr4_57984994_57985389 0.27 IGFBP7
 insulin-like growth factor binding protein 7
 8640
 0.18
chr13_76588981_76589230 0.27 ENSG00000243274
 .
 119962
 0.06
chr22_40592299_40592620 0.27 TNRC6B
 trinucleotide repeat containing 6B
 18513
 0.24
chr18_6730820_6730971 0.27 ARHGAP28
 Rho GTPase activating protein 28
 853
 0.47
chr14_92413096_92413399 0.27 FBLN5
 fibulin 5
 171
 0.96
chr8_97507706_97507857 0.27 SDC2
 syndecan 2
 1545
 0.51
chr9_117877804_117878113 0.27 TNC
 tenascin C
 2520
 0.36
chr22_46933754_46934840 0.27 CELSR1
 cadherin, EGF LAG seven-pass G-type receptor 1
 1230
 0.46
chr2_230138192_230138530 0.27 PID1
 phosphotyrosine interaction domain containing 1
 2360
 0.4
chr10_5045552_5046386 0.27 AKR1C2
 aldo-keto reductase family 1, member C2
 83
 0.93
chr4_26344236_26344574 0.27 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 357
 0.93
chr10_128249841_128250268 0.27 ENSG00000221717
 .
 4421
 0.3
chr6_116834038_116834189 0.26 TRAPPC3L
 trafficking protein particle complex 3-like
 607
 0.55
chr11_121800761_121801203 0.26 ENSG00000252556
 .
 74081
 0.11
chr13_33858125_33858279 0.26 STARD13
 StAR-related lipid transfer (START) domain containing 13
 1690
 0.4
chr16_82049841_82049992 0.26 SDR42E1
 short chain dehydrogenase/reductase family 42E, member 1
 4823
 0.21
chr11_111849006_111849202 0.26 DIXDC1
 DIX domain containing 1
 1071
 0.39
chr9_12777034_12777185 0.26 LURAP1L
 leucine rich adaptor protein 1-like
 2089
 0.33
chr6_27182410_27182602 0.26 PRSS16
 protease, serine, 16 (thymus)
 32974
 0.13
chr3_105657205_105657471 0.26 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 68942
 0.15
chr6_121763088_121763295 0.26 GJA1
 gap junction protein, alpha 1, 43kDa
 6353
 0.19
chr16_51185409_51185597 0.26 SALL1
 spalt-like transcription factor 1
 317
 0.9
chr5_78808053_78808300 0.26 HOMER1
 homer homolog 1 (Drosophila)
 441
 0.86
chr14_62032902_62033075 0.26 RP11-47I22.3
 Uncharacterized protein
 4326
 0.24
chr2_188418561_188419245 0.26 AC007319.1
27
 0.69
chr12_110720958_110721647 0.26 ATP2A2
 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
 1816
 0.41
chr5_3597777_3597928 0.26 IRX1
 iroquois homeobox 1
 1684
 0.41
chr17_13498641_13498792 0.25 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 6528
 0.28
chr4_157873991_157874142 0.25 PDGFC
 platelet derived growth factor C
 17989
 0.21
chr12_91576064_91576215 0.25 DCN
 decorin
 290
 0.94
chr13_79182716_79183828 0.25 POU4F1
 POU class 4 homeobox 1
 5599
 0.19
chr6_21004300_21004557 0.25 ENSG00000252046
 .
 10629
 0.32
chr12_118628413_118628612 0.25 TAOK3
 TAO kinase 3
 156
 0.96
chr5_78204137_78204521 0.25 ARSB
 arylsulfatase B
 77279
 0.11
chr7_82072002_82072462 0.25 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 799
 0.78
chr15_56207406_56207680 0.25 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
 309
 0.92
chr7_55089056_55089207 0.25 EGFR
 epidermal growth factor receptor
 2320
 0.44
chr7_77168081_77168577 0.25 PTPN12
 protein tyrosine phosphatase, non-receptor type 12
 943
 0.69
chr1_65005729_65006114 0.25 ENSG00000264470
 .
 39609
 0.19
chr5_141701461_141701673 0.25 SPRY4
 sprouty homolog 4 (Drosophila)
 2180
 0.34
chr12_47470653_47470804 0.25 PCED1B
 PC-esterase domain containing 1B
 2658
 0.29
chr15_83379003_83379154 0.25 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
 412
 0.78
chr8_60538222_60538702 0.25 ENSG00000201763
 .
 170018
 0.04
chr16_24999320_24999715 0.25 ARHGAP17
 Rho GTPase activating protein 17
 27135
 0.22
chr7_116169835_116170224 0.25 CAV1
 caveolin 1, caveolae protein, 22kDa
 3682
 0.19
chr12_28120085_28120268 0.24 PTHLH
 parathyroid hormone-like hormone
 2251
 0.33
chr4_182568542_182568740 0.24 ENSG00000251742
 .
 187620
 0.03
chr4_80572253_80572434 0.24 OR7E94P
 olfactory receptor, family 7, subfamily E, member 94 pseudogene
 63059
 0.15
chr21_17792302_17792515 0.24 ENSG00000207638
 .
 119001
 0.06
chr5_121517177_121517861 0.24 CTC-441N14.1
25809
 0.17
chr5_53530337_53530488 0.24 ARL15
 ADP-ribosylation factor-like 15
 75991
 0.11
chr8_89289368_89289519 0.24 RP11-586K2.1
49622
 0.16
chr5_92414668_92414956 0.24 ENSG00000237187
 .
 343307
 0.01
chr22_36231482_36231681 0.24 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 4684
 0.32
chr4_89977525_89978081 0.24 FAM13A
 family with sequence similarity 13, member A
 508
 0.85
chr5_55149615_55149792 0.24 IL31RA
 interleukin 31 receptor A
 345
 0.89
chr2_151340168_151340387 0.24 RND3
 Rho family GTPase 3
 1619
 0.57
chr9_89952337_89952906 0.24 ENSG00000212421
 .
 77256
 0.11
chr3_54897831_54897982 0.24 CACNA2D3-AS1
 CACNA2D3 antisense RNA 1
 37376
 0.21
chr9_14096707_14097036 0.24 NFIB
 nuclear factor I/B
 83920
 0.11
chr9_21688149_21688723 0.24 ENSG00000244230
 .
 10877
 0.24
chr8_107738861_107739281 0.23 OXR1
 oxidation resistance 1
 658
 0.71
chr5_120114861_120115414 0.23 ENSG00000222609
 .
 68602
 0.14
chr5_52302561_52302712 0.23 CTD-2175A23.1
16528
 0.2
chr8_107738582_107738843 0.23 OXR1
 oxidation resistance 1
 299
 0.9
chr3_150131286_150131437 0.23 TSC22D2
 TSC22 domain family, member 2
 2565
 0.39
chr2_164590425_164590732 0.23 FIGN
 fidgetin
 1939
 0.52
chr13_76346341_76346549 0.23 LMO7
 LIM domain 7
 11648
 0.26
chr9_111206334_111206588 0.23 ENSG00000222512
 .
 85252
 0.11
chr18_51675978_51676321 0.23 ENSG00000221058
 .
 63123
 0.12
chr9_93732509_93732660 0.23 SYK
 spleen tyrosine kinase
 142814
 0.05
chr3_185539129_185539363 0.23 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
 397
 0.89
chr1_156092284_156092708 0.23 LMNA
 lamin A/C
 3455
 0.14
chr20_57086742_57086893 0.23 APCDD1L
 adenomatosis polyposis coli down-regulated 1-like
 3136
 0.31
chr8_59027426_59027596 0.23 FAM110B
 family with sequence similarity 110, member B
 120398
 0.07
chr13_41220263_41220414 0.23 FOXO1
 forkhead box O1
 20396
 0.22
chr3_12235413_12235694 0.23 TIMP4
 TIMP metallopeptidase inhibitor 4
 34702
 0.2
chr14_68466898_68467139 0.23 CTD-2566J3.1
129895
 0.05
chr20_55207246_55207474 0.22 TFAP2C
 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
 1422
 0.37
chr2_43744394_43744545 0.22 THADA
 thyroid adenoma associated
 53185
 0.14
chr8_125259601_125259830 0.22 ENSG00000206724
 .
 13172
 0.25
chr1_120191467_120191618 0.22 ZNF697
 zinc finger protein 697
 1146
 0.52
chr15_96878465_96878729 0.22 ENSG00000222651
 .
 2107
 0.24
chr14_71022448_71023169 0.22 ADAM20
 ADAM metallopeptidase domain 20
 21076
 0.17
chr22_36232810_36232961 0.22 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 3380
 0.35
chr6_85823864_85824548 0.22 NT5E
 5'-nucleotidase, ecto (CD73)
 335603
 0.01
chr1_150253572_150253809 0.22 C1orf51
 chromosome 1 open reading frame 51
 1263
 0.25
chr18_42313149_42313495 0.22 SETBP1
 SET binding protein 1
 36193
 0.24
chr4_157691847_157691998 0.22 RP11-154F14.2
70589
 0.11
chr14_29859562_29859789 0.22 ENSG00000257522
 .
 11813
 0.29
chr6_5471426_5471612 0.22 RP1-232P20.1
13211
 0.27
chrX_78002931_78003376 0.22 LPAR4
 lysophosphatidic acid receptor 4
 72
 0.99
chr1_234793534_234793917 0.22 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 48454
 0.13
chrX_114829080_114829277 0.22 PLS3
 plastin 3
 1313
 0.48
chr5_87957336_87957520 0.22 ENSG00000245526
 .
 5329
 0.23
chr5_154033985_154034136 0.22 ENSG00000221552
 .
 31276
 0.14
chr2_36581700_36582677 0.22 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 881
 0.74
chr3_127898089_127898282 0.22 RUVBL1
 RuvB-like AAA ATPase 1
 25428
 0.15
chr5_32991481_32991632 0.22 AC026703.1
202611
 0.03
chr12_131201177_131201518 0.22 RIMBP2
 RIMS binding protein 2
 521
 0.86
chr18_53090404_53090609 0.22 TCF4
 transcription factor 4
 763
 0.7
chr21_29233086_29233318 0.22 ENSG00000251894
 .
 882328
 0.0
chr2_133061942_133062584 0.22 ENSG00000221288
 .
 47610
 0.14
chr2_43134028_43134374 0.22 HAAO
 3-hydroxyanthranilate 3,4-dioxygenase
 114469
 0.06
chr9_98188423_98189086 0.22 PTCH1
 patched 1
 54013
 0.12
chr15_88020923_88021173 0.21 ENSG00000207150
 .
 3528
 0.4
chr7_55166552_55166703 0.21 EGFR
 epidermal growth factor receptor
 10789
 0.29
chr4_112951015_112951190 0.21 C4orf32
 chromosome 4 open reading frame 32
 115451
 0.06
chrX_10709343_10709494 0.21 MID1
 midline 1 (Opitz/BBB syndrome)
 63639
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.5 GO:0070141 response to UV-A(GO:0070141)
0.1 0.5 GO:0060437 lung growth(GO:0060437)
0.1 0.3 GO:0072033 renal vesicle formation(GO:0072033)
0.1 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.3 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.3 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.3 GO:0060242 contact inhibition(GO:0060242)
0.1 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.4 GO:0008218 bioluminescence(GO:0008218)
0.1 0.1 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.2 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.3 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.1 0.3 GO:0051503 adenine nucleotide transport(GO:0051503)
0.1 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.3 GO:1903672 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.1 0.2 GO:0022605 oogenesis stage(GO:0022605)
0.1 0.2 GO:0060013 righting reflex(GO:0060013)
0.1 0.2 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.1 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.1 0.2 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0032353 negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0 0.1 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.4 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.2 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0045198 polarized epithelial cell differentiation(GO:0030859) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.2 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.3 GO:0043030 regulation of macrophage activation(GO:0043030)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.5 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.3 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:1903077 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0042637 catagen(GO:0042637)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.2 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0 0.1 GO:0030728 ovulation(GO:0030728)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:1903054 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.4 GO:0008038 neuron recognition(GO:0008038)
0.0 0.2 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390) positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.2 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.3 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.0 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.2 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.3 GO:0048538 thymus development(GO:0048538)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0051284 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.2 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.0 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.0 GO:0010664 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.0 GO:0021825 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.0 GO:0046639 negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.1 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.0 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.4 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.1 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.2 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.2 GO:0006949 syncytium formation(GO:0006949)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.1 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.0 GO:0060592 mammary gland formation(GO:0060592)
0.0 0.2 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.0 GO:0060913 endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214) cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0048566 embryonic digestive tract development(GO:0048566)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.3 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.2 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.0 GO:0031223 auditory behavior(GO:0031223)
0.0 0.0 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0090114 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.0 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.0 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0060527 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0 0.6 GO:0007043 cell-cell junction assembly(GO:0007043)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.0 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0090494 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.1 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.0 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.8 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:0060439 trachea morphogenesis(GO:0060439)
0.0 0.1 GO:0042745 circadian sleep/wake cycle(GO:0042745)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.0 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:0051531 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.0 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.0 GO:0072189 ureter development(GO:0072189)
0.0 0.0 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.0 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.0 GO:0010225 response to UV-C(GO:0010225)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.2 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.0 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0048636 positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0 0.2 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 0.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.0 GO:0045634 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.0 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.0 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0007063 regulation of sister chromatid cohesion(GO:0007063)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.3 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.0 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 1.0 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.2 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.0 GO:0044291 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0044420 extracellular matrix component(GO:0044420)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.0 GO:0045298 tubulin complex(GO:0045298)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.8 GO:0030426 growth cone(GO:0030426)
0.0 0.2 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.0 GO:0070062 extracellular organelle(GO:0043230) extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.2 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.4 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.4 GO:0050815 phosphoserine binding(GO:0050815)
0.1 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.5 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.3 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.0 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.0 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.0 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.0 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.9 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.0 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.5 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.1 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID INSULIN PATHWAY Insulin Pathway
0.0 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.0 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME NEGATIVE REGULATION OF FGFR SIGNALING Genes involved in Negative regulation of FGFR signaling
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions