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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for JUN

Z-value: 1.05

Motif logo

Transcription factors associated with JUN

Gene Symbol	Gene ID	Gene Info
JUN Ensembl NCBI GeneCards UniProt	ENSG00000177606.5	JUN

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
JUN	chr1_59485773_59486035	236119	0.019330	-0.73	2.7e-02	Click!
JUN	chr1_59250006_59250701	568	0.790669	-0.72	3.0e-02	Click!
JUN	chr1_59282219_59282390	32519	0.190534	-0.68	4.3e-02	Click!
JUN	chr1_59250908_59251078	1208	0.521974	-0.65	5.7e-02	Click!
JUN	chr1_59250755_59250906	1045	0.576408	-0.64	6.2e-02	Click!

Activity of the JUN motif across conditions

Conditions sorted by the z-value of the JUN motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_133022737_133022888	1.04	MUC8	mucin 8	27914	0.17
chr17_56744273_56744616	0.59	ENSG00000199426	.	386	0.76
chr11_12695107_12695921	0.56	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	455	0.89
chr8_142141679_142142152	0.54	RP11-809O17.1		1855	0.33
chr3_128207705_128209147	0.50	RP11-475N22.4		326	0.79
chr1_4999527_4999744	0.48	AJAP1	adherens junctions associated protein 1	284530	0.01
chr11_77185235_77185792	0.47	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	167	0.92
chr1_79471738_79472138	0.45	ELTD1	EGF, latrophilin and seven transmembrane domain containing 1	465	0.9
chr6_2111373_2111600	0.43	GMDS	GDP-mannose 4,6-dehydratase	64739	0.15
chr9_18976648_18977105	0.43	FAM154A	family with sequence similarity 154, member A	56310	0.1
chr9_89364915_89365206	0.42	GAS1	growth arrest-specific 1	197044	0.03
chr12_119614350_119614518	0.41	RP11-64B16.3		145	0.94
chr9_120477806_120477957	0.41	ENSG00000201444	.	7501	0.21
chr1_219834214_219834453	0.40	ENSG00000252240	.	2386	0.43
chr19_12639322_12639473	0.40	CTD-2192J16.21		4390	0.14
chr20_33146419_33146919	0.39	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	147	0.95
chr11_89223927_89224152	0.38	NOX4	NADPH oxidase 4	107	0.98
chr16_57842277_57842616	0.38	CTD-2600O9.1	uncharacterized protein LOC388282	2103	0.23
chr12_121725207_121725358	0.37	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	9207	0.21
chr3_112961154_112961680	0.37	BOC	BOC cell adhesion associated, oncogene regulated	26219	0.19
chr6_4491783_4491934	0.36	ENSG00000201185	.	63661	0.14
chr15_40530958_40531718	0.36	PAK6	p21 protein (Cdc42/Rac)-activated kinase 6	46	0.96
chr5_131562588_131563831	0.36	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	138	0.96
chr5_124194835_124194993	0.35	ZNF608	zinc finger protein 608	110414	0.06
chr7_100464814_100466140	0.35	TRIP6	thyroid hormone receptor interactor 6	717	0.47
chr4_169753076_169754370	0.35	RP11-635L1.3		365	0.61
chr12_97300736_97301972	0.35	NEDD1	neural precursor cell expressed, developmentally down-regulated 1	110	0.98
chr19_10678474_10679697	0.35	CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	569	0.54
chr3_187573527_187573678	0.34	BCL6	B-cell CLL/lymphoma 6	110087	0.07
chr8_101522331_101522482	0.34	KB-1615E4.3		17650	0.16
chr8_2199973_2200269	0.34	MYOM2	myomesin 2	206937	0.03
chr1_209846224_209846375	0.34	RP1-28O10.1		2293	0.2
chr7_37956036_37956797	0.33	SFRP4	secreted frizzled-related protein 4	101	0.97
chr6_47276454_47277750	0.33	TNFRSF21	tumor necrosis factor receptor superfamily, member 21	539	0.86
chrX_10126292_10126538	0.33	CLCN4	chloride channel, voltage-sensitive 4	73	0.98
chr9_127024177_127024426	0.33	NEK6	NIMA-related kinase 6	549	0.47
chr17_38497502_38498255	0.32	RARA	retinoic acid receptor, alpha	238	0.84
chr1_167624325_167624476	0.32	RP3-455J7.4		24489	0.17
chr21_45139141_45140358	0.32	PDXK	pyridoxal (pyridoxine, vitamin B6) kinase	756	0.66
chr2_9621262_9621413	0.31	IAH1	isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)	6153	0.18
chr6_30523511_30524213	0.31	GNL1	guanine nucleotide binding protein-like 1	3	0.92
chr2_180214031_180214182	0.31	SESTD1	SEC14 and spectrin domains 1	84589	0.1
chr18_74779349_74779519	0.31	MBP	myelin basic protein	37783	0.2
chr1_240161229_240161618	0.31	FMN2	formin 2	16225	0.27
chr5_126147492_126147682	0.30	LMNB1	lamin B1	34706	0.19
chr3_151102768_151102919	0.30	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	243	0.93
chr2_28939308_28939670	0.30	AC097724.3		19486	0.15
chr1_155734748_155734899	0.30	DAP3	death associated protein 3	28020	0.13
chr16_66638822_66640143	0.30	CMTM3	CKLF-like MARVEL transmembrane domain containing 3	58	0.95
chr10_14920855_14921866	0.30	SUV39H2	suppressor of variegation 3-9 homolog 2 (Drosophila)	439	0.82
chr1_101334241_101334590	0.30	EXTL2	exostosin-like glycosyltransferase 2	25805	0.15
chr9_35489468_35490886	0.30	RUSC2	RUN and SH3 domain containing 2	53	0.97
chr1_46379145_46379296	0.29	MAST2	microtubule associated serine/threonine kinase 2	40	0.98
chr2_192764216_192764367	0.29	AC098617.1		22981	0.23
chr1_203631994_203632193	0.29	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	19844	0.21
chr15_48469342_48470564	0.28	MYEF2	myelin expression factor 2	597	0.66
chr7_121951944_121952095	0.28	FEZF1	FEZ family zinc finger 1	1274	0.46
chr2_204414201_204414352	0.28	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	14143	0.28
chr17_48367766_48367999	0.28	RP11-893F2.9		2666	0.19
chr3_185903259_185903649	0.28	ETV5	ets variant 5	75347	0.1
chr3_184056155_184056581	0.28	FAM131A	family with sequence similarity 131, member A	249	0.84
chr22_38656697_38656971	0.28	TMEM184B	transmembrane protein 184B	11836	0.11
chr2_40264407_40264558	0.28	SLC8A1-AS1	SLC8A1 antisense RNA 1	5008	0.35
chr1_186798918_186799215	0.28	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	944	0.73
chr18_73522464_73522615	0.28	SMIM21	small integral membrane protein 21	382881	0.01
chr5_32033164_32033315	0.28	CTD-2152M20.2		88808	0.07
chr13_32610061_32610212	0.28	FRY-AS1	FRY antisense RNA 1	4360	0.25
chr5_136599797_136599948	0.28	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	49355	0.19
chr18_3262315_3263346	0.27	MYL12B	myosin, light chain 12B, regulatory	124	0.92
chrX_154027559_154027756	0.27	MPP1	membrane protein, palmitoylated 1, 55kDa	6015	0.13
chr3_89163237_89163857	0.27	EPHA3	EPH receptor A3	6721	0.35
chr7_993167_993948	0.27	ADAP1	ArfGAP with dual PH domains 1	776	0.55
chrX_14130141_14130292	0.27	ENSG00000264331	.	36206	0.21
chr22_45664060_45664211	0.27	UPK3A	uroplakin 3A	16728	0.16
chr7_55573864_55574015	0.27	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	9831	0.26
chr1_2187001_2187152	0.27	SKI	v-ski avian sarcoma viral oncogene homolog	26942	0.11
chr8_25056770_25056921	0.27	DOCK5	dedicator of cytokinesis 5	14465	0.23
chr3_11680615_11680766	0.27	VGLL4	vestigial like 4 (Drosophila)	4708	0.24
chr7_33088447_33088598	0.26	ENSG00000241420	.	2820	0.22
chr1_161515451_161515602	0.26	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	4053	0.15
chr3_120168709_120169860	0.26	FSTL1	follistatin-like 1	554	0.84
chr4_173747868_173748019	0.26	ENSG00000241652	.	314851	0.01
chr10_3818147_3818693	0.26	RP11-184A2.2		8313	0.21
chr8_38722630_38723350	0.26	RP11-723D22.3		19033	0.16
chr4_186346547_186347774	0.26	UFSP2	UFM1-specific peptidase 2	21	0.76
chr18_73350794_73351073	0.26	SMIM21	small integral membrane protein 21	211275	0.02
chr18_29629892_29630043	0.26	ENSG00000265063	.	10985	0.14
chr18_74333391_74333920	0.26	LINC00908	long intergenic non-protein coding RNA 908	92781	0.08
chr6_132520617_132520826	0.26	ENSG00000265669	.	84318	0.1
chr4_2010754_2011490	0.26	NELFA	negative elongation factor complex member A	398	0.81
chrX_42106662_42106813	0.26	ENSG00000206896	.	73099	0.12
chr1_9256722_9257085	0.26	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	37931	0.13
chr8_57471403_57471760	0.26	RP11-17A4.2		69924	0.12
chr11_61722707_61723219	0.26	BEST1	bestrophin 1	334	0.82
chr2_101945070_101945221	0.26	ENSG00000264857	.	19233	0.16
chr8_129874103_129874314	0.25	ENSG00000221351	.	42168	0.22
chr13_48718622_48718773	0.25	MED4	mediator complex subunit 4	49430	0.14
chr7_41740779_41741576	0.25	INHBA	inhibin, beta A	970	0.56
chr20_43988486_43988637	0.25	SYS1	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)	2016	0.21
chr10_118764443_118765166	0.25	KIAA1598	KIAA1598	72	0.98
chr2_74097379_74097530	0.25	ACTG2	actin, gamma 2, smooth muscle, enteric	22640	0.15
chr17_79485709_79486744	0.25	RP13-766D20.2		160	0.9
chr5_154026662_154027279	0.25	ENSG00000221552	.	38366	0.13
chr7_4722786_4723588	0.24	FOXK1	forkhead box K1	1247	0.49
chr6_11795100_11795449	0.24	ADTRP	androgen-dependent TFPI-regulating protein	12005	0.28
chr2_172944774_172945201	0.24	DLX1	distal-less homeobox 1	4481	0.24
chr18_61559668_61559819	0.24	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	1952	0.31
chr17_37052701_37052852	0.24	RP1-56K13.2		8077	0.11
chr2_46767914_46768065	0.24	ATP6V1E2	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2	1707	0.26
chr14_101294998_101295174	0.24	AL117190.2		451	0.51
chr13_99227754_99228977	0.24	STK24	serine/threonine kinase 24	752	0.54
chr3_99964720_99964871	0.24	TBC1D23	TBC1 domain family, member 23	15049	0.17
chr8_126557270_126557537	0.24	ENSG00000266452	.	100596	0.08
chr12_10902635_10902853	0.24	YBX3	Y box binding protein 3	26833	0.13
chr1_242097620_242097936	0.24	EXO1	exonuclease 1	55436	0.13
chr2_7144548_7144834	0.24	RNF144A	ring finger protein 144A	7620	0.26
chr3_182977447_182977598	0.23	ENSG00000202502	.	1318	0.46
chr4_6887603_6887754	0.23	TBC1D14	TBC1 domain family, member 14	23291	0.18
chr10_97505576_97505727	0.23	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	9758	0.23
chr10_23983047_23983671	0.23	KIAA1217	KIAA1217	316	0.94
chr17_53342049_53343259	0.23	HLF	hepatic leukemia factor	281	0.93
chr12_4699544_4699695	0.23	DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	57	0.97
chr4_40669941_40670092	0.23	RBM47	RNA binding motif protein 47	37124	0.18
chr2_1609000_1609151	0.23	AC144450.1		14810	0.26
chr13_51253017_51253168	0.23	DLEU7-AS1	DLEU7 antisense RNA 1	128900	0.05
chr2_64864648_64864996	0.23	SERTAD2	SERTA domain containing 2	16225	0.22
chr5_120114458_120114855	0.23	ENSG00000222609	.	68121	0.14
chr17_14507939_14508129	0.23	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	303634	0.01
chr3_42055388_42056674	0.23	ULK4	unc-51 like kinase 4	52109	0.14
chr12_6178520_6178671	0.23	ENSG00000240533	.	26541	0.19
chrX_24043946_24044693	0.23	KLHL15	kelch-like family member 15	984	0.59
chr19_2049519_2050886	0.23	MKNK2	MAP kinase interacting serine/threonine kinase 2	650	0.55
chr7_130712091_130712242	0.22	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	25143	0.19
chr7_99755308_99756343	0.22	C7orf43	chromosome 7 open reading frame 43	182	0.82
chr12_25705930_25706081	0.22	IFLTD1	intermediate filament tail domain containing 1	173	0.97
chr5_131111835_131111986	0.22	FNIP1	folliculin interacting protein 1	20704	0.2
chr4_99443689_99443840	0.22	RP11-724M22.1		26249	0.24
chr19_45242197_45242348	0.22	BCL3	B-cell CLL/lymphoma 3	9532	0.11
chr13_58208642_58209078	0.22	PCDH17	protocadherin 17	2205	0.48
chr6_100316349_100316522	0.22	MCHR2-AS1	MCHR2 antisense RNA 1	125385	0.05
chr17_5371546_5372510	0.22	DHX33	DEAH (Asp-Glu-Ala-His) box polypeptide 33	40	0.96
chr10_62175082_62175240	0.22	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	25673	0.27
chr8_132054499_132054781	0.22	ADCY8	adenylate cyclase 8 (brain)	32	0.99
chr2_166325831_166326039	0.22	CSRNP3	cysteine-serine-rich nuclear protein 3	222	0.96
chr18_10131788_10132277	0.22	ENSG00000263630	.	126838	0.05
chr13_48073693_48073892	0.22	ENSG00000244521	.	40423	0.23
chr11_93275392_93276314	0.22	SMCO4	single-pass membrane protein with coiled-coil domains 4	668	0.7
chr16_75287131_75287498	0.22	BCAR1	breast cancer anti-estrogen resistance 1	1536	0.31
chr10_64392557_64392708	0.22	ZNF365	zinc finger protein 365	10901	0.24
chrX_133688697_133688848	0.22	ENSG00000223749	.	8031	0.12
chr17_29814991_29815971	0.22	RAB11FIP4	RAB11 family interacting protein 4 (class II)	355	0.83
chr18_77866868_77867381	0.22	ADNP2	ADNP homeobox 2	53	0.98
chr11_31834234_31835305	0.21	PAX6	paired box 6	295	0.8
chr6_90695271_90695484	0.21	ENSG00000222078	.	15848	0.19
chr16_11667077_11667228	0.21	LITAF	lipopolysaccharide-induced TNF factor	13077	0.18
chr3_185541036_185541485	0.21	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	1540	0.46
chr2_145265495_145265831	0.21	ZEB2	zinc finger E-box binding homeobox 2	9452	0.25
chr4_30823764_30823915	0.21	RP11-619J20.1		28247	0.26
chr1_221204797_221204948	0.21	HLX	H2.0-like homeobox	150288	0.04
chr2_179395534_179395685	0.21	TTN-AS1	TTN antisense RNA 1	67	0.96
chr10_45956574_45956725	0.21	RP11-67C2.2		8080	0.26
chr19_1019836_1021109	0.21	TMEM259	transmembrane protein 259	373	0.62
chr4_119684707_119684858	0.21	SEC24D	SEC24 family member D	4985	0.3
chr9_95724300_95724451	0.21	FGD3	FYVE, RhoGEF and PH domain containing 3	1868	0.38
chr2_103104653_103104941	0.21	SLC9A4	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	15035	0.18
chr1_184836110_184836261	0.21	ENSG00000252222	.	45562	0.15
chr7_30174028_30174462	0.21	MTURN	maturin, neural progenitor differentiation regulator homolog (Xenopus)	181	0.94
chr19_33686404_33686657	0.21	LRP3	low density lipoprotein receptor-related protein 3	1040	0.41
chr17_79884123_79885283	0.21	MAFG	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	881	0.22
chr11_11418107_11418277	0.21	CSNK2A3	casein kinase 2, alpha 3 polypeptide	43288	0.17
chr12_106229481_106229632	0.21	NUAK1	NUAK family, SNF1-like kinase, 1	248255	0.02
chr4_122060815_122060966	0.21	TNIP3	TNFAIP3 interacting protein 3	2164	0.37
chr14_89412870_89413171	0.21	TTC8	tetratricopeptide repeat domain 8	105148	0.07
chr19_40871912_40872253	0.21	PLD3	phospholipase D family, member 3	181	0.9
chr1_219635246_219635397	0.21	ENSG00000252240	.	201398	0.03
chr7_151433344_151433930	0.21	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	237	0.95
chr17_72453956_72454107	0.21	CD300A	CD300a molecule	8524	0.14
chr6_42283591_42283839	0.21	ENSG00000221252	.	96419	0.06
chr8_28570812_28570963	0.21	EXTL3	exostosin-like glycosyltransferase 3	3012	0.26
chr11_12237907_12238058	0.21	RP11-265D17.2		46738	0.13
chr5_176328832_176328983	0.20	HK3	hexokinase 3 (white cell)	2574	0.31
chr19_58723136_58723287	0.20	ZNF544	zinc finger protein 544	16749	0.11
chr7_8054646_8054797	0.20	AC006042.7		45187	0.13
chr1_112147952_112148103	0.20	RAP1A	RAP1A, member of RAS oncogene family	14372	0.17
chr12_106704608_106704759	0.20	CKAP4	cytoskeleton-associated protein 4	6626	0.18
chr3_185911353_185912009	0.20	ETV5	ets variant 5	83574	0.09
chrX_71321784_71322102	0.20	RGAG4	retrotransposon gag domain containing 4	29735	0.14
chr8_59057981_59058941	0.20	FAM110B	family with sequence similarity 110, member B	151348	0.04
chr1_247611615_247612128	0.20	OR2B11	olfactory receptor, family 2, subfamily B, member 11	3437	0.2
chr18_76828422_76829072	0.20	ATP9B	ATPase, class II, type 9B	538	0.84
chr11_308095_309459	0.20	IFITM2	interferon induced transmembrane protein 2	369	0.66
chr17_53573866_53574017	0.20	ENSG00000200107	.	55230	0.15
chr3_119069123_119069274	0.20	ENSG00000207310	.	8411	0.18
chr15_64643443_64643594	0.20	CSNK1G1	casein kinase 1, gamma 1	4854	0.14
chr4_153561915_153562066	0.20	RP11-768B22.2		25530	0.19
chr2_71300827_71300978	0.20	NAGK	N-acetylglucosamine kinase	235	0.87
chr11_109656621_109656772	0.20	RP11-708B6.2		202063	0.03
chr12_81042956_81043107	0.20	PTPRQ	protein tyrosine phosphatase, receptor type, Q	17030	0.21
chr5_52218355_52218506	0.20	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	66726	0.11
chr14_37050633_37050993	0.20	NKX2-8	NK2 homeobox 8	999	0.51

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.3	GO:0010966	regulation of phosphate transport(GO:0010966)
0.1	0.2	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.2	GO:0042819	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1	0.3	GO:0030321	transepithelial chloride transport(GO:0030321)
0.1	0.2	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.1	0.2	GO:2001279	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1	0.2	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.2	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.5	GO:0035329	hippo signaling(GO:0035329)
0.0	0.3	GO:0042090	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.2	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0045064	T-helper 2 cell differentiation(GO:0045064)
0.0	0.2	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.5	GO:0042554	superoxide anion generation(GO:0042554)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.4	GO:1905037	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.3	GO:0051567	histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.4	GO:0006984	ER-nucleus signaling pathway(GO:0006984)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:1903054	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.2	GO:0000731	DNA synthesis involved in DNA repair(GO:0000731)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.2	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.0	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0060992	response to fungicide(GO:0060992)
0.0	0.1	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.0	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.2	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836) endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0048841	regulation of axon extension involved in axon guidance(GO:0048841)
0.0	0.2	GO:0051156	glucose 6-phosphate metabolic process(GO:0051156)
0.0	0.1	GO:0006884	cell volume homeostasis(GO:0006884)
0.0	0.1	GO:0001885	endothelial cell development(GO:0001885)
0.0	0.0	GO:0015793	glycerol transport(GO:0015793)
0.0	0.2	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.0	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.2	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.1	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0006907	pinocytosis(GO:0006907)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.0	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.0	GO:0003079	obsolete positive regulation of natriuresis(GO:0003079)
0.0	0.2	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.4	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.3	GO:0042588	zymogen granule(GO:0042588)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.0	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.0	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.4	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	0.4	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.1	0.4	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.3	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.2	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.2	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.5	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.2	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.2	GO:0051184	cofactor transporter activity(GO:0051184)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.6	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.2	ST ADRENERGIC	Adrenergic Pathway
0.0	0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.2	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.3	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway