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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for JUND

Z-value: 1.73

Motif logo

Transcription factors associated with JUND

Gene Symbol	Gene ID	Gene Info
JUND Ensembl NCBI GeneCards UniProt	ENSG00000130522.4	JUND

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
JUND	chr19_18388821_18388972	2843	0.131727	0.48	1.9e-01	Click!
JUND	chr19_18389064_18389254	2580	0.140432	0.39	3.0e-01	Click!
JUND	chr19_18389866_18390017	1798	0.187139	0.19	6.2e-01	Click!
JUND	chr19_18391872_18392200	297	0.725285	-0.18	6.4e-01	Click!
JUND	chr19_18390478_18391041	980	0.341134	0.13	7.4e-01	Click!

Activity of the JUND motif across conditions

Conditions sorted by the z-value of the JUND motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_33373915_33374211	0.80	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	4693	0.13
chr5_35857058_35857643	0.74	IL7R	interleukin 7 receptor	356	0.89
chr11_118794237_118794443	0.73	BCL9L	B-cell CLL/lymphoma 9-like	4727	0.09
chr14_22971834_22972057	0.73	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	15774	0.09
chr4_122164507_122165136	0.71	TNIP3	TNFAIP3 interacting protein 3	16200	0.22
chr18_9117310_9117583	0.69	RP11-143J12.3		1571	0.34
chr4_143325352_143326244	0.68	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	26614	0.28
chr6_139852295_139852446	0.65	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	156613	0.04
chr5_156616289_156616440	0.64	ITK	IL2-inducible T-cell kinase	8527	0.13
chr5_151907362_151907513	0.64	NMUR2	neuromedin U receptor 2	122597	0.07
chr1_160489868_160490211	0.62	SLAMF6	SLAM family member 6	2993	0.18
chr1_160767367_160767518	0.61	LY9	lymphocyte antigen 9	1465	0.39
chr2_231789411_231789754	0.60	GPR55	G protein-coupled receptor 55	359	0.85
chr12_92172716_92172989	0.59	C12orf79	chromosome 12 open reading frame 79	357945	0.01
chr22_31335429_31335580	0.59	MORC2	MORC family CW-type zinc finger 2	6623	0.16
chr11_128376572_128377141	0.58	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	1567	0.47
chr1_117297247_117297398	0.58	CD2	CD2 molecule	233	0.94
chr9_73027094_73027481	0.57	KLF9	Kruppel-like factor 9	2253	0.41
chr12_21606326_21606605	0.56	PYROXD1	pyridine nucleotide-disulphide oxidoreductase domain 1	15616	0.17
chr4_151540397_151540583	0.56	ENSG00000221235	.	20528	0.2
chr6_90993958_90994705	0.55	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	12130	0.24
chr12_51418457_51418700	0.55	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	48	0.96
chr1_12509705_12509856	0.54	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	15215	0.22
chr1_154299291_154299442	0.54	ATP8B2	ATPase, aminophospholipid transporter, class I, type 8B, member 2	910	0.38
chr22_37545294_37545803	0.53	IL2RB	interleukin 2 receptor, beta	482	0.7
chr18_7958694_7958932	0.53	PTPRM	protein tyrosine phosphatase, receptor type, M	11861	0.23
chr4_143477803_143478104	0.53	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	3869	0.39
chr9_130732789_130732970	0.53	FAM102A	family with sequence similarity 102, member A	9913	0.11
chr3_179372008_179372371	0.53	USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)	708	0.65
chr2_223654006_223654270	0.53	ACSL3	acyl-CoA synthetase long-chain family member 3	71514	0.1
chr12_45625038_45625189	0.52	ANO6	anoctamin 6	15210	0.28
chr4_26024061_26024293	0.51	SMIM20	small integral membrane protein 20	108246	0.07
chr5_52336982_52337335	0.51	CTD-2366F13.2		48140	0.12
chr12_96592768_96592919	0.51	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	4451	0.24
chr20_3913213_3913723	0.51	ENSG00000199024	.	15327	0.15
chr18_3459636_3459787	0.50	TGIF1	TGFB-induced factor homeobox 1	4299	0.25
chr20_48510567_48510837	0.50	SPATA2	spermatogenesis associated 2	19574	0.13
chr18_9118459_9118745	0.50	RP11-143J12.3		2727	0.22
chr21_15906632_15906783	0.50	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	11955	0.25
chr3_187520878_187521148	0.49	BCL6	B-cell CLL/lymphoma 6	57498	0.14
chr6_42391109_42391260	0.49	ENSG00000221252	.	11050	0.21
chr10_6183056_6183884	0.48	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	3411	0.18
chr13_64046885_64047036	0.48	LINC00395	long intergenic non-protein coding RNA 395	244191	0.02
chr8_17784028_17784466	0.48	PCM1	pericentriolar material 1	1994	0.33
chr13_50940025_50940517	0.48	ENSG00000221198	.	2898	0.4
chr15_57214479_57214630	0.48	TCF12	transcription factor 12	3208	0.26
chr2_12861826_12862019	0.47	TRIB2	tribbles pseudokinase 2	3558	0.31
chr20_62368732_62368892	0.47	LIME1	Lck interacting transmembrane adaptor 1	175	0.82
chr5_125759997_125760148	0.47	GRAMD3	GRAM domain containing 3	922	0.67
chr2_161347323_161347474	0.47	RBMS1	RNA binding motif, single stranded interacting protein 1	2631	0.39
chr9_80454914_80455065	0.47	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	17074	0.29
chr3_97591431_97591802	0.46	CRYBG3	beta-gamma crystallin domain containing 3	4203	0.29
chr14_99728002_99728348	0.46	AL109767.1		1110	0.55
chr15_57199778_57200042	0.46	ZNF280D	zinc finger protein 280D	10859	0.22
chr3_69137280_69137433	0.45	ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	3184	0.19
chr12_27975145_27975352	0.45	ENSG00000201612	.	15925	0.14
chr1_239711433_239711584	0.45	CHRM3	cholinergic receptor, muscarinic 3	80865	0.11
chr10_121464981_121465132	0.45	INPP5F	inositol polyphosphate-5-phosphatase F	20553	0.2
chr12_50614114_50614771	0.45	RP3-405J10.4		1055	0.35
chr6_106428787_106428953	0.45	ENSG00000200198	.	76622	0.11
chr17_68133569_68133739	0.45	AC002539.1		8654	0.19
chr2_205660028_205660179	0.44	PARD3B	par-3 family cell polarity regulator beta	249380	0.02
chr6_106550011_106550199	0.44	RP1-134E15.3		2090	0.34
chr3_173342884_173343035	0.44	NLGN1	neuroligin 1	20570	0.29
chr10_12762743_12762973	0.44	ENSG00000221331	.	4494	0.33
chrY_18612478_18612629	0.44	ENSG00000252323	.	164284	0.04
chr14_99706254_99706405	0.43	AL109767.1		22956	0.19
chr10_531510_531790	0.43	RP11-490E15.2		48149	0.14
chr15_26095881_26096079	0.43	ENSG00000266517	.	2008	0.32
chr1_226919354_226919568	0.43	ITPKB	inositol-trisphosphate 3-kinase B	5698	0.25
chr7_80589868_80590019	0.43	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	38268	0.23
chr11_58341076_58341416	0.42	LPXN	leupaxin	2088	0.26
chr18_60253252_60253584	0.42	ZCCHC2	zinc finger, CCHC domain containing 2	46671	0.15
chr16_50779002_50779153	0.42	RP11-327F22.1		2351	0.16
chr9_5510404_5511024	0.42	PDCD1LG2	programmed cell death 1 ligand 2	144	0.97
chr11_62308687_62309106	0.42	RP11-864I4.3		4112	0.1
chr12_47606378_47606570	0.42	PCED1B	PC-esterase domain containing 1B	3578	0.27
chr2_85165728_85166011	0.42	KCMF1	potassium channel modulatory factor 1	32347	0.14
chr13_76867689_76867887	0.42	ENSG00000243274	.	158721	0.04
chr17_8294973_8295124	0.42	RNF222	ring finger protein 222	1759	0.2
chr7_43709455_43709606	0.41	COA1	cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)	19635	0.2
chr3_12436703_12437398	0.41	PPARG	peroxisome proliferator-activated receptor gamma	44079	0.15
chr1_178096168_178096398	0.41	RASAL2	RAS protein activator like 2	33007	0.24
chr10_3239818_3240224	0.41	PITRM1	pitrilysin metallopeptidase 1	25018	0.22
chr17_18089190_18089923	0.41	RP11-258F1.1		1489	0.25
chr1_205263608_205263759	0.41	NUAK2	NUAK family, SNF1-like kinase, 2	27200	0.13
chr2_106363775_106364396	0.40	NCK2	NCK adaptor protein 2	1897	0.48
chr17_78735104_78735701	0.39	RP11-28G8.1		44030	0.16
chr3_128898182_128898356	0.39	CNBP	CCHC-type zinc finger, nucleic acid binding protein	4473	0.15
chr2_102720712_102721707	0.39	IL1R1	interleukin 1 receptor, type I	180	0.96
chrY_16456835_16457019	0.39	ENSG00000266220	.	92756	0.09
chr14_68717009_68717160	0.39	ENSG00000243546	.	13828	0.27
chr20_30948041_30948438	0.39	ASXL1	additional sex combs like 1 (Drosophila)	689	0.71
chr17_75641513_75641796	0.39	SEPT9	septin 9	163659	0.03
chr14_23015461_23015710	0.39	AE000662.92	Uncharacterized protein	9949	0.11
chr14_69130333_69130485	0.39	CTD-2325P2.3		21873	0.2
chr3_67040557_67040708	0.38	KBTBD8	kelch repeat and BTB (POZ) domain containing 8	8095	0.34
chr3_50354430_50354581	0.38	HYAL2	hyaluronoglucosaminidase 2	3874	0.08
chr6_112145118_112145500	0.38	FYN	FYN oncogene related to SRC, FGR, YES	4028	0.33
chr1_116919885_116920582	0.38	ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	3744	0.2
chr3_21788888_21789039	0.38	ZNF385D	zinc finger protein 385D	3964	0.35
chr6_136968777_136969043	0.38	MAP3K5	mitogen-activated protein kinase kinase kinase 5	8689	0.18
chr6_119398292_119398443	0.38	FAM184A	family with sequence similarity 184, member A	1170	0.49
chr1_111215065_111215351	0.38	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	2447	0.28
chr6_139467434_139467700	0.38	HECA	headcase homolog (Drosophila)	11318	0.25
chr8_102914659_102914810	0.38	ENSG00000238372	.	55146	0.15
chrX_78196699_78196850	0.38	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	4055	0.37
chr1_231762136_231762321	0.37	DISC1	disrupted in schizophrenia 1	333	0.89
chr12_47613140_47613338	0.37	PCED1B	PC-esterase domain containing 1B	2858	0.3
chrX_115456567_115456718	0.37	ENSG00000207033	.	75471	0.11
chr7_28369849_28370167	0.37	CREB5	cAMP responsive element binding protein 5	31068	0.23
chr8_141599639_141599927	0.37	AGO2	argonaute RISC catalytic component 2	16204	0.22
chr12_865415_865972	0.37	WNK1	WNK lysine deficient protein kinase 1	2961	0.28
chr12_92524835_92525431	0.37	C12orf79	chromosome 12 open reading frame 79	5664	0.19
chr20_52199257_52199767	0.37	ZNF217	zinc finger protein 217	124	0.96
chr4_154855782_154855933	0.37	ENSG00000252181	.	61254	0.14
chr1_55701600_55701751	0.37	ENSG00000265822	.	10361	0.22
chr14_22977741_22978031	0.37	TRAJ15	T cell receptor alpha joining 15	20694	0.09
chr5_130617107_130617383	0.36	CDC42SE2	CDC42 small effector 2	17452	0.27
chr5_54450782_54450933	0.36	GPX8	glutathione peroxidase 8 (putative)	5089	0.13
chr13_103357618_103357769	0.36	METTL21C	methyltransferase like 21C	10839	0.14
chr7_150146102_150146542	0.36	GIMAP8	GTPase, IMAP family member 8	1396	0.39
chr1_89531148_89531299	0.36	GBP1	guanylate binding protein 1, interferon-inducible	180	0.94
chrY_15016828_15017148	0.36	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	246	0.96
chr5_67576190_67576341	0.36	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	130	0.98
chr14_22458708_22459003	0.36	ENSG00000238634	.	152032	0.04
chr21_32553132_32553283	0.35	TIAM1	T-cell lymphoma invasion and metastasis 1	50668	0.17
chr9_124991302_124991453	0.35	LHX6	LIM homeobox 6	157	0.94
chr16_80603632_80603783	0.35	RP11-525K10.3		6675	0.18
chr16_11346250_11346518	0.35	RMI2	RecQ mediated genome instability 2	2878	0.13
chr6_119398487_119399078	0.35	FAM184A	family with sequence similarity 184, member A	755	0.67
chr6_36985827_36986032	0.35	FGD2	FYVE, RhoGEF and PH domain containing 2	12506	0.17
chr6_160883573_160883724	0.35	LPAL2	lipoprotein, Lp(a)-like 2, pseudogene	48391	0.17
chr14_22982199_22982350	0.35	TRAJ15	T cell receptor alpha joining 15	16306	0.1
chr16_86795095_86795257	0.35	FOXL1	forkhead box L1	183061	0.03
chr1_26704591_26705236	0.35	ZNF683	zinc finger protein 683	3900	0.15
chr1_151795357_151795508	0.35	RORC	RAR-related orphan receptor C	3135	0.1
chr10_92079410_92079561	0.34	ENSG00000222451	.	155768	0.04
chr8_128811686_128811837	0.34	ENSG00000249859	.	3553	0.33
chr6_16421411_16421759	0.34	ENSG00000265642	.	7169	0.31
chr2_138710392_138710640	0.34	HNMT	histamine N-methyltransferase	11074	0.32
chr3_5233234_5233385	0.34	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	3275	0.19
chr4_109082592_109082835	0.34	LEF1	lymphoid enhancer-binding factor 1	4744	0.25
chr11_102189311_102189462	0.34	BIRC3	baculoviral IAP repeat containing 3	1092	0.48
chr16_66907243_66907451	0.34	NAE1	NEDD8 activating enzyme E1 subunit 1	188	0.9
chr2_196523306_196523815	0.33	SLC39A10	solute carrier family 39 (zinc transporter), member 10	1387	0.5
chr10_52191698_52191849	0.33	AC069547.2	Uncharacterized protein	39007	0.15
chr17_43389731_43389977	0.33	ENSG00000199953	.	15009	0.13
chr22_40307152_40307436	0.33	GRAP2	GRB2-related adaptor protein 2	10181	0.17
chrX_13680096_13680380	0.33	TCEANC	transcription elongation factor A (SII) N-terminal and central domain containing	6824	0.2
chr8_23075544_23076103	0.33	ENSG00000246582	.	6161	0.12
chr10_134776485_134776636	0.32	TTC40	tetratricopeptide repeat domain 40	20233	0.23
chr10_8099206_8099457	0.32	GATA3	GATA binding protein 3	2562	0.44
chr10_90030880_90031226	0.32	ENSG00000200891	.	276601	0.01
chr6_209971_210123	0.32	DUSP22	dual specificity phosphatase 22	81583	0.11
chr10_124135009_124135427	0.32	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	868	0.6
chr1_9030857_9031244	0.32	ENSG00000265141	.	8883	0.16
chr1_16292676_16293171	0.32	ZBTB17	zinc finger and BTB domain containing 17	9651	0.13
chr18_67624277_67624428	0.32	CD226	CD226 molecule	60	0.99
chr15_61013207_61013362	0.32	ENSG00000212625	.	15684	0.2
chr9_14029932_14030102	0.32	NFIB	nuclear factor I/B	150774	0.05
chr2_31639599_31639781	0.32	XDH	xanthine dehydrogenase	2109	0.44
chr11_35163942_35164467	0.32	CD44	CD44 molecule (Indian blood group)	3351	0.21
chr8_42748827_42749465	0.32	ENSG00000266044	.	2272	0.19
chr1_78471059_78471251	0.32	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	617	0.53
chr17_38019811_38019962	0.32	IKZF3	IKAROS family zinc finger 3 (Aiolos)	493	0.74
chr17_73680522_73680673	0.31	RP11-474I11.7		282	0.82
chr3_181342247_181342398	0.31	SOX2-OT	SOX2 overlapping transcript (non-protein coding)	13925	0.28
chr9_128463330_128463481	0.31	MAPKAP1	mitogen-activated protein kinase associated protein 1	6051	0.28
chr21_32533248_32533535	0.31	TIAM1	T-cell lymphoma invasion and metastasis 1	30852	0.23
chr8_135643662_135643813	0.31	ZFAT	zinc finger and AT hook domain containing	8386	0.27
chr15_86247440_86247591	0.31	RP11-815J21.1		3175	0.16
chr7_2910047_2910285	0.31	GNA12	guanine nucleotide binding protein (G protein) alpha 12	26208	0.2
chr13_98859522_98859872	0.31	ENSG00000263399	.	1081	0.44
chr20_25290950_25291163	0.31	ABHD12	abhydrolase domain containing 12	922	0.6
chr1_85763681_85764097	0.31	ENSG00000264380	.	13596	0.14
chr19_1168749_1168988	0.30	SBNO2	strawberry notch homolog 2 (Drosophila)	74	0.95
chr9_33446136_33446606	0.30	AQP3	aquaporin 3 (Gill blood group)	1238	0.41
chr10_33405368_33405626	0.30	ENSG00000263576	.	17933	0.22
chr2_151335990_151336454	0.30	RND3	Rho family GTPase 3	5674	0.35
chr2_231191950_231192650	0.30	SP140L	SP140 nuclear body protein-like	315	0.92
chr12_33072283_33072434	0.30	PKP2	plakophilin 2	22584	0.26
chr10_47640402_47640757	0.30	ANTXRLP1	anthrax toxin receptor-like pseudogene 1	4212	0.25
chr18_60825953_60826104	0.30	RP11-299P2.1		7475	0.24
chr2_12862265_12862722	0.30	TRIB2	tribbles pseudokinase 2	4129	0.3
chr15_33493746_33494182	0.30	FMN1	formin 1	7067	0.29
chr6_142948626_142948785	0.30	RP1-67K17.3		120875	0.06
chr13_110999770_111000142	0.30	COL4A2	collagen, type IV, alpha 2	40342	0.15
chr7_130783126_130783277	0.30	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	8588	0.21
chr9_18268349_18268500	0.30	ADAMTSL1	ADAMTS-like 1	205468	0.03
chr18_64911369_64911711	0.30	ENSG00000265580	.	51979	0.18
chr2_162915924_162916075	0.30	AC008063.2		13767	0.2
chr6_33384140_33384291	0.30	PHF1	PHD finger protein 1	1373	0.23
chr10_76345165_76345892	0.30	ENSG00000206756	.	34378	0.2
chr7_14022721_14022872	0.29	ETV1	ets variant 1	3270	0.34
chrY_20488207_20488358	0.29	ENSG00000251953	.	19842	0.19
chr1_158902534_158902685	0.29	PYHIN1	pyrin and HIN domain family, member 1	1251	0.51
chrX_2553752_2553903	0.29	CD99P1	CD99 molecule pseudogene 1	26371	0.2
chr2_235402543_235402910	0.29	ARL4C	ADP-ribosylation factor-like 4C	2518	0.45
chr13_41236803_41237000	0.29	FOXO1	forkhead box O1	3833	0.29

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.2	0.6	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2	0.5	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.1	0.1	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1	0.3	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.3	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.5	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.1	0.4	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.3	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.1	0.3	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.3	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.1	0.3	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.1	0.2	GO:0002913	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.1	0.2	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.3	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.1	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.1	0.2	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1	0.3	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1	0.3	GO:0002507	tolerance induction(GO:0002507)
0.1	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.4	GO:0002423	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1	0.3	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.1	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.1	0.2	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.3	GO:0002347	response to tumor cell(GO:0002347)
0.1	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.4	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.2	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.5	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0014808	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0	0.2	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.3	GO:0048535	lymph node development(GO:0048535)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.3	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.2	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.2	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.5	GO:0042130	negative regulation of T cell proliferation(GO:0042130)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.2	GO:0015074	DNA integration(GO:0015074)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.1	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.1	GO:0051323	mitotic metaphase(GO:0000089) metaphase(GO:0051323)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.0	GO:0046621	negative regulation of organ growth(GO:0046621)
0.0	0.2	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.4	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.2	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:0032691	negative regulation of interleukin-1 beta production(GO:0032691)
0.0	0.0	GO:0051608	histamine transport(GO:0051608)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0060134	prepulse inhibition(GO:0060134)
0.0	0.0	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.2	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0070253	somatostatin secretion(GO:0070253)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.4	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.1	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.4	GO:0006829	zinc II ion transport(GO:0006829)
0.0	0.0	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.1	GO:0090312	regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.4	GO:0006997	nucleus organization(GO:0006997)
0.0	0.2	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.0	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.2	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.0	GO:0002823	negative regulation of adaptive immune response(GO:0002820) negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(GO:0002823)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.0	GO:0035268	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0060087	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.2	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.2	GO:0042308	negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0046541	saliva secretion(GO:0046541)
0.0	0.0	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0090559	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.1	GO:0071326	cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0	0.1	GO:0007176	regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0	0.1	GO:0006991	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.0	GO:0015840	urea transport(GO:0015840)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.3	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0051597	response to methylmercury(GO:0051597)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0051926	negative regulation of calcium ion transport(GO:0051926)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.0	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.1	GO:0006105	succinate metabolic process(GO:0006105)
0.0	0.2	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.0	GO:0060896	neural plate pattern specification(GO:0060896)
0.0	0.0	GO:0055117	regulation of cardiac muscle contraction(GO:0055117)
0.0	0.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.0	GO:0071218	cellular response to misfolded protein(GO:0071218)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.0	0.1	GO:0010171	body morphogenesis(GO:0010171)
0.0	0.1	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.4	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.5	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.7	GO:0045178	basal part of cell(GO:0045178)
0.0	0.2	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.3	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.4	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.5	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.0	GO:0044216	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.0	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.0	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.0	GO:0043260	laminin-11 complex(GO:0043260)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0016151	nickel cation binding(GO:0016151)
0.2	0.5	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.4	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.3	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1	0.3	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.5	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.6	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	0.2	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1	0.2	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.3	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.2	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.3	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.2	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0	0.4	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.3	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.4	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.3	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.6	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.3	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.2	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.0	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.3	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.0	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.2	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.0	PID INSULIN PATHWAY	Insulin Pathway
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.6	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.4	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.3	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	0.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.1	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.5	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.4	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.5	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.4	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.0	0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.2	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.0	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE