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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for KLF1

Z-value: 0.91

Motif logo

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Transcription factors associated with KLF1

Gene Symbol Gene ID Gene Info
KLF1
ENSG00000105610.4 Kruppel like factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_12997276_12997427KLF16440.4076090.618.0e-02Click!
chr19_12996769_12996974KLF111240.2151010.608.8e-02Click!
chr19_12996052_12996768KLF115850.1442820.294.5e-01Click!
chr19_12995815_12995996KLF120900.1089740.265.1e-01Click!

Activity of the KLF1 motif across conditions

Conditions sorted by the z-value of the KLF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_73718374_73718525 0.54 ITGB4
 integrin, beta 4
 872
 0.43
chr2_86055147_86055298 0.41 ENSG00000252321
 .
 7487
 0.17
chr2_160918347_160919586 0.36 PLA2R1
 phospholipase A2 receptor 1, 180kDa
 155
 0.98
chr18_33333968_33334119 0.32 GALNT1
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
 99423
 0.07
chr8_25105948_25106099 0.30 DOCK5
 dedicator of cytokinesis 5
 50435
 0.16
chr10_126840512_126840747 0.29 CTBP2
 C-terminal binding protein 2
 6656
 0.3
chr1_956379_957022 0.29 AGRN
 agrin
 1197
 0.27
chr1_243651138_243651433 0.29 RP11-269F20.1
57549
 0.15
chr18_28958892_28959043 0.27 DSG4
 desmoglein 4
 2121
 0.23
chr1_183558268_183558419 0.26 NCF2
 neutrophil cytosolic factor 2
 1373
 0.44
chr17_7348839_7349178 0.25 CHRNB1
 cholinergic receptor, nicotinic, beta 1 (muscle)
 158
 0.84
chr22_45635380_45635531 0.25 KIAA0930
 KIAA0930
 1195
 0.46
chr3_133614813_133615159 0.24 RAB6B
 RAB6B, member RAS oncogene family
 306
 0.92
chr11_130029601_130029752 0.24 ST14
 suppression of tumorigenicity 14 (colon carcinoma)
 219
 0.96
chr2_113735443_113735594 0.24 IL36G
 interleukin 36, gamma
 78
 0.97
chr22_19102804_19102955 0.23 AC004471.9
6163
 0.12
chr7_150755256_150755900 0.23 CDK5
 cyclin-dependent kinase 5
 39
 0.77
chr10_82245695_82245846 0.22 TSPAN14
 tetraspanin 14
 26712
 0.17
chr3_184209968_184210530 0.22 EIF2B5-IT1
 EIF2B5 intronic transcript 1 (non-protein coding)
 12652
 0.18
chr10_50398410_50398651 0.22 C10orf128
 chromosome 10 open reading frame 128
 2094
 0.33
chr17_76123581_76124282 0.21 TMC6
 transmembrane channel-like 6
 780
 0.49
chr11_65346255_65346406 0.20 EHBP1L1
 EH domain binding protein 1-like 1
 2813
 0.1
chr13_99328229_99328380 0.20 ENSG00000243366
 .
 4070
 0.29
chr3_49943448_49943849 0.20 CTD-2330K9.3
 Uncharacterized protein
 2228
 0.16
chr9_113979_114607 0.20 FOXD4
 forkhead box D4
 4124
 0.25
chr17_16977527_16977700 0.20 MPRIP-AS1
 MPRIP antisense RNA 1
 3453
 0.23
chr19_13113568_13113719 0.20 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 6991
 0.09
chr12_114334146_114334297 0.20 RP11-780K2.1
36153
 0.21
chr7_158750572_158750973 0.20 ENSG00000231419
 .
 50340
 0.16
chr22_38291318_38291469 0.19 ENSG00000207227
 .
 4039
 0.12
chr8_22847583_22847734 0.19 RHOBTB2
 Rho-related BTB domain containing 2
 2663
 0.19
chr10_120739922_120740073 0.19 RP11-498J9.2
23399
 0.15
chr8_144657322_144657645 0.19 RP11-661A12.9
1823
 0.12
chr3_49170609_49171370 0.19 LAMB2
 laminin, beta 2 (laminin S)
 438
 0.69
chr8_144697320_144697471 0.19 TSTA3
 tissue specific transplantation antigen P35B
 1239
 0.21
chr10_123313697_123313848 0.19 FGFR2
 fibroblast growth factor receptor 2
 22944
 0.27
chr2_114260314_114260465 0.19 FOXD4L1
 forkhead box D4-like 1
 3728
 0.22
chr10_46010179_46010570 0.19 MARCH8
 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
 20445
 0.22
chr14_24783731_24783882 0.19 LTB4R
 leukotriene B4 receptor
 100
 0.9
chr15_77286572_77286762 0.18 PSTPIP1
 proline-serine-threonine phosphatase interacting protein 1
 759
 0.66
chr10_74082676_74082827 0.18 DNAJB12
 DnaJ (Hsp40) homolog, subfamily B, member 12
 21968
 0.16
chr22_23599471_23599622 0.18 BCR
 breakpoint cluster region
 3399
 0.21
chr19_12274174_12274895 0.18 ZNF136
 zinc finger protein 136
 603
 0.62
chr1_958272_958423 0.18 AGRN
 agrin
 2844
 0.12
chr18_76261468_76261619 0.18 ENSG00000201723
 .
 42645
 0.22
chr16_50313127_50313376 0.18 ADCY7
 adenylate cyclase 7
 187
 0.95
chr2_114083135_114083388 0.18 PAX8
 paired box 8
 46734
 0.11
chr17_73860377_73860686 0.18 WBP2
 WW domain binding protein 2
 7943
 0.08
chr5_6767017_6767234 0.17 PAPD7
 PAP associated domain containing 7
 52380
 0.15
chr18_46460407_46461027 0.17 SMAD7
 SMAD family member 7
 14158
 0.24
chr17_43248472_43248682 0.17 RP13-890H12.2
275
 0.83
chr9_132406657_132406808 0.17 ASB6
 ankyrin repeat and SOCS box containing 6
 2288
 0.19
chr20_39970036_39970187 0.17 LPIN3
 lipin 3
 551
 0.77
chr9_137275051_137275202 0.17 ENSG00000263897
 .
 3869
 0.28
chr17_35214294_35214445 0.17 RP11-445F12.1
79552
 0.07
chr8_145009573_145009909 0.17 PLEC
 plectin
 4017
 0.13
chr10_129843979_129844130 0.17 PTPRE
 protein tyrosine phosphatase, receptor type, E
 1616
 0.51
chr15_41195326_41195612 0.17 VPS18
 vacuolar protein sorting 18 homolog (S. cerevisiae)
 8804
 0.11
chr11_3181150_3181578 0.17 OSBPL5
 oxysterol binding protein-like 5
 1259
 0.4
chr9_137248904_137249055 0.17 ENSG00000263897
 .
 22278
 0.21
chr21_45590544_45590695 0.17 AP001055.1
2961
 0.19
chr17_48998464_48998615 0.17 TOB1
 transducer of ERBB2, 1
 53200
 0.1
chr14_96691207_96691358 0.17 RP11-404P21.1
9156
 0.12
chr11_12112400_12112551 0.17 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 3068
 0.36
chr3_48636571_48636823 0.16 COL7A1
 collagen, type VII, alpha 1
 3997
 0.11
chr1_155102531_155102783 0.16 EFNA1
 ephrin-A1
 2305
 0.11
chr2_134898080_134898231 0.16 ENSG00000263813
 .
 13459
 0.23
chr16_15236302_15236453 0.16 ENSG00000207294
 .
 8177
 0.11
chr16_31213085_31213654 0.16 C16orf98
 chromosome 16 open reading frame 98
 163
 0.81
chr18_3327008_3327159 0.16 MYL12B
 myosin, light chain 12B, regulatory
 64129
 0.09
chr20_60388194_60388345 0.16 RP11-429E11.2
58157
 0.14
chr9_137444566_137444717 0.16 COL5A1
 collagen, type V, alpha 1
 88979
 0.08
chr1_38510289_38510696 0.16 POU3F1
 POU class 3 homeobox 1
 1958
 0.27
chr14_105436556_105437076 0.16 AHNAK2
 AHNAK nucleoprotein 2
 7878
 0.16
chr17_76879212_76879961 0.16 TIMP2
 TIMP metallopeptidase inhibitor 2
 9354
 0.14
chrX_153666039_153666841 0.16 GDI1
 GDP dissociation inhibitor 1
 1174
 0.23
chr14_100048320_100048471 0.16 ENSG00000200506
 .
 959
 0.49
chr15_29434000_29434151 0.16 ENSG00000252868
 .
 91997
 0.08
chr20_17502066_17502217 0.15 BFSP1
 beaded filament structural protein 1, filensin
 9873
 0.23
chr19_49840027_49840178 0.15 CD37
 CD37 molecule
 370
 0.72
chr1_3390049_3390200 0.15 ARHGEF16
 Rho guanine nucleotide exchange factor (GEF) 16
 1936
 0.35
chr6_108972255_108972979 0.15 FOXO3
 forkhead box O3
 4932
 0.33
chr1_156877457_156877608 0.15 LRRC71
 leucine rich repeat containing 71
 12910
 0.12
chr8_23754300_23754592 0.15 STC1
 stanniocalcin 1
 42126
 0.17
chr7_116141197_116141631 0.15 CAV2
 caveolin 2
 1580
 0.29
chr6_36684370_36684521 0.15 RAB44
 RAB44, member RAS oncogene family
 1189
 0.44
chrX_49033222_49033373 0.15 PLP2
 proteolipid protein 2 (colonic epithelium-enriched)
 5024
 0.09
chr7_75357800_75357951 0.15 HIP1
 huntingtin interacting protein 1
 10384
 0.21
chr19_3097024_3097175 0.15 GNA11
 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
 2691
 0.16
chr12_122468241_122468392 0.15 BCL7A
 B-cell CLL/lymphoma 7A
 8524
 0.22
chr17_46103279_46103479 0.14 COPZ2
 coatomer protein complex, subunit zeta 2
 7859
 0.09
chr9_135819104_135820215 0.14 TSC1
 tuberous sclerosis 1
 349
 0.7
chr10_45476062_45476312 0.14 C10orf10
 chromosome 10 open reading frame 10
 1929
 0.22
chr22_39147328_39147855 0.14 SUN2
 Sad1 and UNC84 domain containing 2
 1272
 0.23
chr2_75185375_75185738 0.14 POLE4
 polymerase (DNA-directed), epsilon 4, accessory subunit
 63
 0.98
chr4_25031967_25032301 0.14 LGI2
 leucine-rich repeat LGI family, member 2
 153
 0.97
chr11_64951074_64951225 0.14 CAPN1
 calpain 1, (mu/I) large subunit
 342
 0.74
chr7_87257054_87258255 0.14 RUNDC3B
 RUN domain containing 3B
 75
 0.97
chr9_14322549_14323229 0.14 NFIB
 nuclear factor I/B
 552
 0.82
chr8_144714709_144714860 0.14 RP11-661A12.12
1142
 0.24
chr9_114361613_114362271 0.14 PTGR1
 prostaglandin reductase 1
 33
 0.97
chr15_96903147_96903373 0.14 AC087477.1
 Uncharacterized protein
 1227
 0.45
chr3_5055062_5055354 0.14 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 33562
 0.15
chr18_74779548_74779839 0.14 MBP
 myelin basic protein
 37524
 0.2
chrX_41301675_41302169 0.14 NYX
 nyctalopin
 4765
 0.25
chr11_72451789_72452038 0.14 ARAP1
 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
 11535
 0.12
chr9_137235953_137236130 0.14 RXRA
 retinoid X receptor, alpha
 17615
 0.22
chr14_24784022_24784248 0.14 LTB4R
 leukotriene B4 receptor
 229
 0.8
chr12_120662827_120663239 0.14 PXN
 paxillin
 480
 0.71
chr11_1897109_1897260 0.14 LSP1
 lymphocyte-specific protein 1
 523
 0.63
chr16_389783_389934 0.14 AXIN1
 axin 1
 12591
 0.1
chr15_47476270_47477144 0.14 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 409
 0.87
chr22_46475652_46475803 0.13 FLJ27365
 hsa-mir-4763
 465
 0.67
chr12_41582969_41583319 0.13 PDZRN4
 PDZ domain containing ring finger 4
 894
 0.75
chr17_75311931_75312082 0.13 SEPT9
 septin 9
 3591
 0.27
chr19_51433227_51433378 0.13 KLK4
 kallikrein-related peptidase 4
 19308
 0.07
chr17_43205399_43205692 0.13 PLCD3
 phospholipase C, delta 3
 4346
 0.12
chr5_68710635_68711790 0.13 MARVELD2
 MARVEL domain containing 2
 3
 0.97
chr19_2045769_2045920 0.13 MKNK2
 MAP kinase interacting serine/threonine kinase 2
 3212
 0.14
chr2_106886104_106886958 0.13 UXS1
 UDP-glucuronate decarboxylase 1
 75736
 0.1
chr5_111755303_111755604 0.13 EPB41L4A-AS2
 EPB41L4A antisense RNA 2 (head to head)
 173
 0.78
chr19_11805219_11805471 0.13 CTC-499B15.4
11984
 0.13
chr2_69534033_69534297 0.13 ENSG00000252250
 .
 27567
 0.2
chr6_125203961_125204112 0.13 RNF217
 ring finger protein 217
 79655
 0.11
chr2_43333094_43333245 0.13 ENSG00000207087
 .
 14537
 0.28
chr11_64479921_64480072 0.13 NRXN2
 neurexin 2
 221
 0.91
chr7_5638418_5638613 0.13 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 4198
 0.19
chr2_28600742_28600893 0.13 FOSL2
 FOS-like antigen 2
 14852
 0.16
chr9_130590515_130590893 0.13 ENSG00000222421
 .
 4318
 0.09
chr7_5638779_5639073 0.13 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 4609
 0.19
chr1_43473710_43473861 0.13 ENSG00000252803
 .
 15523
 0.17
chr4_1288964_1289115 0.13 MAEA
 macrophage erythroblast attacher
 5356
 0.16
chr18_77664931_77665082 0.13 KCNG2
 potassium voltage-gated channel, subfamily G, member 2
 41338
 0.14
chr1_154979820_154980060 0.13 ZBTB7B
 zinc finger and BTB domain containing 7B
 4645
 0.08
chr1_222884853_222885497 0.13 AIDA
 axin interactor, dorsalization associated
 595
 0.46
chr19_18201957_18202170 0.12 IL12RB1
 interleukin 12 receptor, beta 1
 4250
 0.16
chr19_5903751_5904369 0.12 FUT5
 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
 262
 0.34
chr6_56614643_56614951 0.12 DST
 dystonin
 35880
 0.21
chr1_1280074_1280225 0.12 DVL1
 dishevelled segment polarity protein 1
 4343
 0.08
chr5_175199924_175200075 0.12 CPLX2
 complexin 2
 23314
 0.2
chr11_95770968_95771151 0.12 MTMR2
 myotubularin related protein 2
 113600
 0.07
chr19_1856293_1856444 0.12 CTB-31O20.8
3881
 0.1
chr10_24754741_24755189 0.12 KIAA1217
 KIAA1217
 495
 0.84
chr18_32990029_32990180 0.12 ZNF396
 zinc finger protein 396
 32803
 0.17
chr5_131795063_131795214 0.12 ENSG00000202533
 .
 8701
 0.13
chr17_79989895_79990665 0.12 RAC3
 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
 220
 0.81
chr19_751908_752059 0.12 MISP
 mitotic spindle positioning
 857
 0.44
chr9_88358324_88358790 0.12 AGTPBP1
 ATP/GTP binding protein 1
 1613
 0.56
chr9_140089237_140089388 0.12 TPRN
 taperin
 5245
 0.06
chr7_1164684_1164835 0.12 C7orf50
 chromosome 7 open reading frame 50
 13117
 0.12
chr21_31311288_31312406 0.12 GRIK1
 glutamate receptor, ionotropic, kainate 1
 3
 0.99
chr20_61463695_61464080 0.12 COL9A3
 collagen, type IX, alpha 3
 14724
 0.11
chr3_186079383_186079733 0.12 DGKG
 diacylglycerol kinase, gamma 90kDa
 188
 0.97
chr15_81426568_81426818 0.12 C15orf26
 chromosome 15 open reading frame 26
 105
 0.98
chr19_16994486_16994637 0.12 F2RL3
 coagulation factor II (thrombin) receptor-like 3
 5110
 0.13
chr8_144653425_144654110 0.12 MROH6
 maestro heat-like repeat family member 6
 1151
 0.21
chr11_561033_561967 0.12 RASSF7
 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
 47
 0.89
chr1_110772672_110772823 0.12 KCNC4
 potassium voltage-gated channel, Shaw-related subfamily, member 4
 18625
 0.12
chr15_41795749_41795900 0.12 ITPKA
 inositol-trisphosphate 3-kinase A
 9751
 0.13
chr1_119543496_119543659 0.12 TBX15
 T-box 15
 11398
 0.25
chr2_97198141_97198292 0.12 RP11-363D14.1
173
 0.95
chr3_136677917_136678068 0.12 IL20RB
 interleukin 20 receptor beta
 1141
 0.51
chr20_62710337_62711142 0.12 RGS19
 regulator of G-protein signaling 19
 106
 0.88
chr9_22006120_22006693 0.12 CDKN2B
 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
 2546
 0.22
chr5_150159569_150159738 0.12 AC010441.1
1786
 0.26
chr13_50194281_50194827 0.12 ARL11
 ADP-ribosylation factor-like 11
 7881
 0.21
chr3_53033553_53033704 0.12 SFMBT1
 Scm-like with four mbt domains 1
 45653
 0.12
chr7_101796468_101796619 0.12 ENSG00000252824
 .
 40901
 0.15
chr9_137248251_137248693 0.12 ENSG00000263897
 .
 22785
 0.21
chr9_137258318_137258525 0.12 ENSG00000263897
 .
 12836
 0.24
chr1_209603784_209603935 0.12 ENSG00000230937
 .
 1619
 0.52
chr6_7553448_7553719 0.11 DSP
 desmoplakin
 11733
 0.19
chr3_49384336_49384565 0.11 USP4
 ubiquitin specific peptidase 4 (proto-oncogene)
 6946
 0.11
chr14_61123462_61124719 0.11 SIX1
 SIX homeobox 1
 887
 0.64
chr2_217501949_217502100 0.11 IGFBP2
 insulin-like growth factor binding protein 2, 36kDa
 3906
 0.22
chr17_70515597_70515748 0.11 ENSG00000200783
 .
 144619
 0.05
chr17_7342306_7342601 0.11 FGF11
 fibroblast growth factor 11
 107
 0.87
chr20_55754754_55754905 0.11 RP4-813D12.2
35099
 0.17
chr18_55746256_55746407 0.11 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
 31873
 0.2
chr17_64670217_64670368 0.11 AC006947.1
2198
 0.33
chr14_77512028_77512179 0.11 IRF2BPL
 interferon regulatory factor 2 binding protein-like
 17069
 0.17
chr17_18280756_18280929 0.11 EVPLL
 envoplakin-like
 134
 0.93
chr9_140130864_140131015 0.11 TUBB4B
 tubulin, beta 4B class IVb
 4726
 0.06
chr17_76136415_76136566 0.11 C17orf99
 chromosome 17 open reading frame 99
 5944
 0.12
chr1_227015373_227015524 0.11 PSEN2
 presenilin 2 (Alzheimer disease 4)
 42437
 0.16
chr5_10635837_10635988 0.11 ANKRD33B-AS1
 ANKRD33B antisense RNA 1
 7575
 0.25
chr1_40425789_40425948 0.11 MFSD2A
 major facilitator superfamily domain containing 2A
 5046
 0.17
chr15_31653592_31653811 0.11 KLF13
 Kruppel-like factor 13
 4656
 0.34
chr3_12700084_12700501 0.11 RAF1
 v-raf-1 murine leukemia viral oncogene homolog 1
 5324
 0.21
chr19_41933992_41934158 0.11 B3GNT8
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
 560
 0.56
chr6_10383738_10384217 0.11 TFAP2A
 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
 20850
 0.18
chr10_134402361_134402743 0.11 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 18878
 0.23
chr4_185723588_185724132 0.11 ACSL1
 acyl-CoA synthetase long-chain family member 1
 3082
 0.25
chr7_121436163_121436314 0.11 ENSG00000252704
 .
 59741
 0.14
chrX_22670943_22671094 0.11 ENSG00000265819
 .
 15909
 0.29
chr16_67213263_67213414 0.11 KIAA0895L
 KIAA0895-like
 627
 0.43
chr1_1244917_1245068 0.11 PUSL1
 pseudouridylate synthase-like 1
 791
 0.33
chr10_77167336_77167780 0.11 ENSG00000237149
 .
 4746
 0.21
chr1_208374584_208374735 0.11 PLXNA2
 plexin A2
 43006
 0.22
chr16_2173775_2174214 0.11 RP11-304L19.2
4786
 0.06

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.2 GO:0003179 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.2 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0051832 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0015816 glycine transport(GO:0015816)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.1 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0052167 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.2 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.1 GO:0009648 photoperiodism(GO:0009648)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.1 GO:0035610 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0048293 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0032823 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0036296 response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0 0.0 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.0 GO:0045007 depurination(GO:0045007)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.3 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:0031103 axon regeneration(GO:0031103)
0.0 0.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0003010 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.0 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.1 GO:0036473 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.0 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0043441 acetoacetic acid biosynthetic process(GO:0043441)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.0 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.0 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0 0.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043260 laminin-11 complex(GO:0043260)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.0 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0 0.1 GO:0005605 basal lamina(GO:0005605)
0.0 0.0 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.2 GO:0042166 acetylcholine binding(GO:0042166)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.1 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.0 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.0 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.0 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.0 ST G ALPHA S PATHWAY G alpha s Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.0 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels