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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for KLF1

Z-value: 0.91

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Transcription factors associated with KLF1

Gene Symbol	Gene ID	Gene Info
KLF1 Ensembl NCBI GeneCards UniProt	ENSG00000105610.4	KLF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
KLF1	chr19_12997276_12997427	644	0.407609	0.61	8.0e-02	Click!
KLF1	chr19_12996769_12996974	1124	0.215101	0.60	8.8e-02	Click!
KLF1	chr19_12996052_12996768	1585	0.144282	0.29	4.5e-01	Click!
KLF1	chr19_12995815_12995996	2090	0.108974	0.26	5.1e-01	Click!

Activity of the KLF1 motif across conditions

Conditions sorted by the z-value of the KLF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_73718374_73718525	0.54	ITGB4	integrin, beta 4	872	0.43
chr2_86055147_86055298	0.41	ENSG00000252321	.	7487	0.17
chr2_160918347_160919586	0.36	PLA2R1	phospholipase A2 receptor 1, 180kDa	155	0.98
chr18_33333968_33334119	0.32	GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	99423	0.07
chr8_25105948_25106099	0.30	DOCK5	dedicator of cytokinesis 5	50435	0.16
chr10_126840512_126840747	0.29	CTBP2	C-terminal binding protein 2	6656	0.3
chr1_956379_957022	0.29	AGRN	agrin	1197	0.27
chr1_243651138_243651433	0.29	RP11-269F20.1		57549	0.15
chr18_28958892_28959043	0.27	DSG4	desmoglein 4	2121	0.23
chr1_183558268_183558419	0.26	NCF2	neutrophil cytosolic factor 2	1373	0.44
chr17_7348839_7349178	0.25	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)	158	0.84
chr22_45635380_45635531	0.25	KIAA0930	KIAA0930	1195	0.46
chr3_133614813_133615159	0.24	RAB6B	RAB6B, member RAS oncogene family	306	0.92
chr11_130029601_130029752	0.24	ST14	suppression of tumorigenicity 14 (colon carcinoma)	219	0.96
chr2_113735443_113735594	0.24	IL36G	interleukin 36, gamma	78	0.97
chr22_19102804_19102955	0.23	AC004471.9		6163	0.12
chr7_150755256_150755900	0.23	CDK5	cyclin-dependent kinase 5	39	0.77
chr10_82245695_82245846	0.22	TSPAN14	tetraspanin 14	26712	0.17
chr3_184209968_184210530	0.22	EIF2B5-IT1	EIF2B5 intronic transcript 1 (non-protein coding)	12652	0.18
chr10_50398410_50398651	0.22	C10orf128	chromosome 10 open reading frame 128	2094	0.33
chr17_76123581_76124282	0.21	TMC6	transmembrane channel-like 6	780	0.49
chr11_65346255_65346406	0.20	EHBP1L1	EH domain binding protein 1-like 1	2813	0.1
chr13_99328229_99328380	0.20	ENSG00000243366	.	4070	0.29
chr3_49943448_49943849	0.20	CTD-2330K9.3	Uncharacterized protein	2228	0.16
chr9_113979_114607	0.20	FOXD4	forkhead box D4	4124	0.25
chr17_16977527_16977700	0.20	MPRIP-AS1	MPRIP antisense RNA 1	3453	0.23
chr19_13113568_13113719	0.20	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	6991	0.09
chr12_114334146_114334297	0.20	RP11-780K2.1		36153	0.21
chr7_158750572_158750973	0.20	ENSG00000231419	.	50340	0.16
chr22_38291318_38291469	0.19	ENSG00000207227	.	4039	0.12
chr8_22847583_22847734	0.19	RHOBTB2	Rho-related BTB domain containing 2	2663	0.19
chr10_120739922_120740073	0.19	RP11-498J9.2		23399	0.15
chr8_144657322_144657645	0.19	RP11-661A12.9		1823	0.12
chr3_49170609_49171370	0.19	LAMB2	laminin, beta 2 (laminin S)	438	0.69
chr8_144697320_144697471	0.19	TSTA3	tissue specific transplantation antigen P35B	1239	0.21
chr10_123313697_123313848	0.19	FGFR2	fibroblast growth factor receptor 2	22944	0.27
chr2_114260314_114260465	0.19	FOXD4L1	forkhead box D4-like 1	3728	0.22
chr10_46010179_46010570	0.19	MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	20445	0.22
chr14_24783731_24783882	0.19	LTB4R	leukotriene B4 receptor	100	0.9
chr15_77286572_77286762	0.18	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	759	0.66
chr10_74082676_74082827	0.18	DNAJB12	DnaJ (Hsp40) homolog, subfamily B, member 12	21968	0.16
chr22_23599471_23599622	0.18	BCR	breakpoint cluster region	3399	0.21
chr19_12274174_12274895	0.18	ZNF136	zinc finger protein 136	603	0.62
chr1_958272_958423	0.18	AGRN	agrin	2844	0.12
chr18_76261468_76261619	0.18	ENSG00000201723	.	42645	0.22
chr16_50313127_50313376	0.18	ADCY7	adenylate cyclase 7	187	0.95
chr2_114083135_114083388	0.18	PAX8	paired box 8	46734	0.11
chr17_73860377_73860686	0.18	WBP2	WW domain binding protein 2	7943	0.08
chr5_6767017_6767234	0.17	PAPD7	PAP associated domain containing 7	52380	0.15
chr18_46460407_46461027	0.17	SMAD7	SMAD family member 7	14158	0.24
chr17_43248472_43248682	0.17	RP13-890H12.2		275	0.83
chr9_132406657_132406808	0.17	ASB6	ankyrin repeat and SOCS box containing 6	2288	0.19
chr20_39970036_39970187	0.17	LPIN3	lipin 3	551	0.77
chr9_137275051_137275202	0.17	ENSG00000263897	.	3869	0.28
chr17_35214294_35214445	0.17	RP11-445F12.1		79552	0.07
chr8_145009573_145009909	0.17	PLEC	plectin	4017	0.13
chr10_129843979_129844130	0.17	PTPRE	protein tyrosine phosphatase, receptor type, E	1616	0.51
chr15_41195326_41195612	0.17	VPS18	vacuolar protein sorting 18 homolog (S. cerevisiae)	8804	0.11
chr11_3181150_3181578	0.17	OSBPL5	oxysterol binding protein-like 5	1259	0.4
chr9_137248904_137249055	0.17	ENSG00000263897	.	22278	0.21
chr21_45590544_45590695	0.17	AP001055.1		2961	0.19
chr17_48998464_48998615	0.17	TOB1	transducer of ERBB2, 1	53200	0.1
chr14_96691207_96691358	0.17	RP11-404P21.1		9156	0.12
chr11_12112400_12112551	0.17	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	3068	0.36
chr3_48636571_48636823	0.16	COL7A1	collagen, type VII, alpha 1	3997	0.11
chr1_155102531_155102783	0.16	EFNA1	ephrin-A1	2305	0.11
chr2_134898080_134898231	0.16	ENSG00000263813	.	13459	0.23
chr16_15236302_15236453	0.16	ENSG00000207294	.	8177	0.11
chr16_31213085_31213654	0.16	C16orf98	chromosome 16 open reading frame 98	163	0.81
chr18_3327008_3327159	0.16	MYL12B	myosin, light chain 12B, regulatory	64129	0.09
chr20_60388194_60388345	0.16	RP11-429E11.2		58157	0.14
chr9_137444566_137444717	0.16	COL5A1	collagen, type V, alpha 1	88979	0.08
chr1_38510289_38510696	0.16	POU3F1	POU class 3 homeobox 1	1958	0.27
chr14_105436556_105437076	0.16	AHNAK2	AHNAK nucleoprotein 2	7878	0.16
chr17_76879212_76879961	0.16	TIMP2	TIMP metallopeptidase inhibitor 2	9354	0.14
chrX_153666039_153666841	0.16	GDI1	GDP dissociation inhibitor 1	1174	0.23
chr14_100048320_100048471	0.16	ENSG00000200506	.	959	0.49
chr15_29434000_29434151	0.16	ENSG00000252868	.	91997	0.08
chr20_17502066_17502217	0.15	BFSP1	beaded filament structural protein 1, filensin	9873	0.23
chr19_49840027_49840178	0.15	CD37	CD37 molecule	370	0.72
chr1_3390049_3390200	0.15	ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16	1936	0.35
chr6_108972255_108972979	0.15	FOXO3	forkhead box O3	4932	0.33
chr1_156877457_156877608	0.15	LRRC71	leucine rich repeat containing 71	12910	0.12
chr8_23754300_23754592	0.15	STC1	stanniocalcin 1	42126	0.17
chr7_116141197_116141631	0.15	CAV2	caveolin 2	1580	0.29
chr6_36684370_36684521	0.15	RAB44	RAB44, member RAS oncogene family	1189	0.44
chrX_49033222_49033373	0.15	PLP2	proteolipid protein 2 (colonic epithelium-enriched)	5024	0.09
chr7_75357800_75357951	0.15	HIP1	huntingtin interacting protein 1	10384	0.21
chr19_3097024_3097175	0.15	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	2691	0.16
chr12_122468241_122468392	0.15	BCL7A	B-cell CLL/lymphoma 7A	8524	0.22
chr17_46103279_46103479	0.14	COPZ2	coatomer protein complex, subunit zeta 2	7859	0.09
chr9_135819104_135820215	0.14	TSC1	tuberous sclerosis 1	349	0.7
chr10_45476062_45476312	0.14	C10orf10	chromosome 10 open reading frame 10	1929	0.22
chr22_39147328_39147855	0.14	SUN2	Sad1 and UNC84 domain containing 2	1272	0.23
chr2_75185375_75185738	0.14	POLE4	polymerase (DNA-directed), epsilon 4, accessory subunit	63	0.98
chr4_25031967_25032301	0.14	LGI2	leucine-rich repeat LGI family, member 2	153	0.97
chr11_64951074_64951225	0.14	CAPN1	calpain 1, (mu/I) large subunit	342	0.74
chr7_87257054_87258255	0.14	RUNDC3B	RUN domain containing 3B	75	0.97
chr9_14322549_14323229	0.14	NFIB	nuclear factor I/B	552	0.82
chr8_144714709_144714860	0.14	RP11-661A12.12		1142	0.24
chr9_114361613_114362271	0.14	PTGR1	prostaglandin reductase 1	33	0.97
chr15_96903147_96903373	0.14	AC087477.1	Uncharacterized protein	1227	0.45
chr3_5055062_5055354	0.14	BHLHE40-AS1	BHLHE40 antisense RNA 1	33562	0.15
chr18_74779548_74779839	0.14	MBP	myelin basic protein	37524	0.2
chrX_41301675_41302169	0.14	NYX	nyctalopin	4765	0.25
chr11_72451789_72452038	0.14	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	11535	0.12
chr9_137235953_137236130	0.14	RXRA	retinoid X receptor, alpha	17615	0.22
chr14_24784022_24784248	0.14	LTB4R	leukotriene B4 receptor	229	0.8
chr12_120662827_120663239	0.14	PXN	paxillin	480	0.71
chr11_1897109_1897260	0.14	LSP1	lymphocyte-specific protein 1	523	0.63
chr16_389783_389934	0.14	AXIN1	axin 1	12591	0.1
chr15_47476270_47477144	0.14	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	409	0.87
chr22_46475652_46475803	0.13	FLJ27365	hsa-mir-4763	465	0.67
chr12_41582969_41583319	0.13	PDZRN4	PDZ domain containing ring finger 4	894	0.75
chr17_75311931_75312082	0.13	SEPT9	septin 9	3591	0.27
chr19_51433227_51433378	0.13	KLK4	kallikrein-related peptidase 4	19308	0.07
chr17_43205399_43205692	0.13	PLCD3	phospholipase C, delta 3	4346	0.12
chr5_68710635_68711790	0.13	MARVELD2	MARVEL domain containing 2	3	0.97
chr19_2045769_2045920	0.13	MKNK2	MAP kinase interacting serine/threonine kinase 2	3212	0.14
chr2_106886104_106886958	0.13	UXS1	UDP-glucuronate decarboxylase 1	75736	0.1
chr5_111755303_111755604	0.13	EPB41L4A-AS2	EPB41L4A antisense RNA 2 (head to head)	173	0.78
chr19_11805219_11805471	0.13	CTC-499B15.4		11984	0.13
chr2_69534033_69534297	0.13	ENSG00000252250	.	27567	0.2
chr6_125203961_125204112	0.13	RNF217	ring finger protein 217	79655	0.11
chr2_43333094_43333245	0.13	ENSG00000207087	.	14537	0.28
chr11_64479921_64480072	0.13	NRXN2	neurexin 2	221	0.91
chr7_5638418_5638613	0.13	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	4198	0.19
chr2_28600742_28600893	0.13	FOSL2	FOS-like antigen 2	14852	0.16
chr9_130590515_130590893	0.13	ENSG00000222421	.	4318	0.09
chr7_5638779_5639073	0.13	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	4609	0.19
chr1_43473710_43473861	0.13	ENSG00000252803	.	15523	0.17
chr4_1288964_1289115	0.13	MAEA	macrophage erythroblast attacher	5356	0.16
chr18_77664931_77665082	0.13	KCNG2	potassium voltage-gated channel, subfamily G, member 2	41338	0.14
chr1_154979820_154980060	0.13	ZBTB7B	zinc finger and BTB domain containing 7B	4645	0.08
chr1_222884853_222885497	0.13	AIDA	axin interactor, dorsalization associated	595	0.46
chr19_18201957_18202170	0.12	IL12RB1	interleukin 12 receptor, beta 1	4250	0.16
chr19_5903751_5904369	0.12	FUT5	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	262	0.34
chr6_56614643_56614951	0.12	DST	dystonin	35880	0.21
chr1_1280074_1280225	0.12	DVL1	dishevelled segment polarity protein 1	4343	0.08
chr5_175199924_175200075	0.12	CPLX2	complexin 2	23314	0.2
chr11_95770968_95771151	0.12	MTMR2	myotubularin related protein 2	113600	0.07
chr19_1856293_1856444	0.12	CTB-31O20.8		3881	0.1
chr10_24754741_24755189	0.12	KIAA1217	KIAA1217	495	0.84
chr18_32990029_32990180	0.12	ZNF396	zinc finger protein 396	32803	0.17
chr5_131795063_131795214	0.12	ENSG00000202533	.	8701	0.13
chr17_79989895_79990665	0.12	RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	220	0.81
chr19_751908_752059	0.12	MISP	mitotic spindle positioning	857	0.44
chr9_88358324_88358790	0.12	AGTPBP1	ATP/GTP binding protein 1	1613	0.56
chr9_140089237_140089388	0.12	TPRN	taperin	5245	0.06
chr7_1164684_1164835	0.12	C7orf50	chromosome 7 open reading frame 50	13117	0.12
chr21_31311288_31312406	0.12	GRIK1	glutamate receptor, ionotropic, kainate 1	3	0.99
chr20_61463695_61464080	0.12	COL9A3	collagen, type IX, alpha 3	14724	0.11
chr3_186079383_186079733	0.12	DGKG	diacylglycerol kinase, gamma 90kDa	188	0.97
chr15_81426568_81426818	0.12	C15orf26	chromosome 15 open reading frame 26	105	0.98
chr19_16994486_16994637	0.12	F2RL3	coagulation factor II (thrombin) receptor-like 3	5110	0.13
chr8_144653425_144654110	0.12	MROH6	maestro heat-like repeat family member 6	1151	0.21
chr11_561033_561967	0.12	RASSF7	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	47	0.89
chr1_110772672_110772823	0.12	KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	18625	0.12
chr15_41795749_41795900	0.12	ITPKA	inositol-trisphosphate 3-kinase A	9751	0.13
chr1_119543496_119543659	0.12	TBX15	T-box 15	11398	0.25
chr2_97198141_97198292	0.12	RP11-363D14.1		173	0.95
chr3_136677917_136678068	0.12	IL20RB	interleukin 20 receptor beta	1141	0.51
chr20_62710337_62711142	0.12	RGS19	regulator of G-protein signaling 19	106	0.88
chr9_22006120_22006693	0.12	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	2546	0.22
chr5_150159569_150159738	0.12	AC010441.1		1786	0.26
chr13_50194281_50194827	0.12	ARL11	ADP-ribosylation factor-like 11	7881	0.21
chr3_53033553_53033704	0.12	SFMBT1	Scm-like with four mbt domains 1	45653	0.12
chr7_101796468_101796619	0.12	ENSG00000252824	.	40901	0.15
chr9_137248251_137248693	0.12	ENSG00000263897	.	22785	0.21
chr9_137258318_137258525	0.12	ENSG00000263897	.	12836	0.24
chr1_209603784_209603935	0.12	ENSG00000230937	.	1619	0.52
chr6_7553448_7553719	0.11	DSP	desmoplakin	11733	0.19
chr3_49384336_49384565	0.11	USP4	ubiquitin specific peptidase 4 (proto-oncogene)	6946	0.11
chr14_61123462_61124719	0.11	SIX1	SIX homeobox 1	887	0.64
chr2_217501949_217502100	0.11	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	3906	0.22
chr17_70515597_70515748	0.11	ENSG00000200783	.	144619	0.05
chr17_7342306_7342601	0.11	FGF11	fibroblast growth factor 11	107	0.87
chr20_55754754_55754905	0.11	RP4-813D12.2		35099	0.17
chr18_55746256_55746407	0.11	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	31873	0.2
chr17_64670217_64670368	0.11	AC006947.1		2198	0.33
chr14_77512028_77512179	0.11	IRF2BPL	interferon regulatory factor 2 binding protein-like	17069	0.17
chr17_18280756_18280929	0.11	EVPLL	envoplakin-like	134	0.93
chr9_140130864_140131015	0.11	TUBB4B	tubulin, beta 4B class IVb	4726	0.06
chr17_76136415_76136566	0.11	C17orf99	chromosome 17 open reading frame 99	5944	0.12
chr1_227015373_227015524	0.11	PSEN2	presenilin 2 (Alzheimer disease 4)	42437	0.16
chr5_10635837_10635988	0.11	ANKRD33B-AS1	ANKRD33B antisense RNA 1	7575	0.25
chr1_40425789_40425948	0.11	MFSD2A	major facilitator superfamily domain containing 2A	5046	0.17
chr15_31653592_31653811	0.11	KLF13	Kruppel-like factor 13	4656	0.34
chr3_12700084_12700501	0.11	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	5324	0.21
chr19_41933992_41934158	0.11	B3GNT8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	560	0.56
chr6_10383738_10384217	0.11	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	20850	0.18
chr10_134402361_134402743	0.11	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	18878	0.23
chr4_185723588_185724132	0.11	ACSL1	acyl-CoA synthetase long-chain family member 1	3082	0.25
chr7_121436163_121436314	0.11	ENSG00000252704	.	59741	0.14
chrX_22670943_22671094	0.11	ENSG00000265819	.	15909	0.29
chr16_67213263_67213414	0.11	KIAA0895L	KIAA0895-like	627	0.43
chr1_1244917_1245068	0.11	PUSL1	pseudouridylate synthase-like 1	791	0.33
chr10_77167336_77167780	0.11	ENSG00000237149	.	4746	0.21
chr1_208374584_208374735	0.11	PLXNA2	plexin A2	43006	0.22
chr16_2173775_2174214	0.11	RP11-304L19.2		4786	0.06

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.2	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.2	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.2	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.1	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0052167	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.2	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0009648	photoperiodism(GO:0009648)
0.0	0.2	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0048293	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0036296	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.0	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.2	GO:0031103	axon regeneration(GO:0031103)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.0	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.0	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.0	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.1	GO:0060406	positive regulation of penile erection(GO:0060406)
0.0	0.1	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.0	0.0	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.1	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0043260	laminin-11 complex(GO:0043260)
0.1	0.2	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0	0.1	GO:0005605	basal lamina(GO:0005605)
0.0	0.0	GO:0032591	dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.3	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.0	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.0	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.0	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.4	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	ST G ALPHA S PATHWAY	G alpha s Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.0	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.0	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels