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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for KLF12

Z-value: 2.01

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Transcription factors associated with KLF12

Gene Symbol	Gene ID	Gene Info
KLF12 Ensembl NCBI GeneCards UniProt	ENSG00000118922.12	KLF12

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
KLF12	chr13_74706686_74707383	1360	0.610790	-0.84	4.8e-03	Click!
KLF12	chr13_74707575_74707914	650	0.836514	-0.79	1.2e-02	Click!
KLF12	chr13_74636992_74637192	67906	0.143868	-0.77	1.5e-02	Click!
KLF12	chr13_74709839_74710349	1700	0.539429	-0.72	2.8e-02	Click!
KLF12	chr13_74710350_74710633	2097	0.481476	-0.68	4.4e-02	Click!

Activity of the KLF12 motif across conditions

Conditions sorted by the z-value of the KLF12 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_197831468_197832400	1.52	AC073135.3		5143	0.19
chr3_197825673_197826397	1.51	AC073135.3		11042	0.16
chr10_126916927_126917078	0.68	CTBP2	C-terminal binding protein 2	67372	0.13
chr6_166795582_166796398	0.63	MPC1	mitochondrial pyruvate carrier 1	496	0.56
chrX_48797424_48797575	0.62	OTUD5	OTU domain containing 5	16952	0.08
chrX_70330517_70330974	0.62	IL2RG	interleukin 2 receptor, gamma	553	0.61
chr6_154677089_154677240	0.61	IPCEF1	interaction protein for cytohesin exchange factors 1	705	0.8
chr3_197828693_197828955	0.61	AC073135.3		8253	0.17
chr11_47399612_47399968	0.60	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene	152	0.91
chr11_63273553_63274069	0.59	LGALS12	lectin, galactoside-binding, soluble, 12	24	0.97
chr3_197831153_197831453	0.56	AC073135.3		5774	0.19
chr17_76912776_76912997	0.51	TIMP2	TIMP metallopeptidase inhibitor 2	5597	0.15
chr3_197829934_197830170	0.51	AC073135.3		7025	0.18
chr5_177870010_177870161	0.49	CTB-26E19.1		10	0.98
chr5_178094483_178094634	0.46	CLK4	CDC-like kinase 4	40443	0.14
chr21_46955435_46955710	0.45	SLC19A1	solute carrier family 19 (folate transporter), member 1	1043	0.57
chr3_194456850_194457149	0.44	FAM43A	family with sequence similarity 43, member A	50377	0.11
chr9_132097203_132097398	0.43	ENSG00000242281	.	35440	0.16
chr3_197827066_197827292	0.42	AC073135.3		9898	0.17
chr20_60760834_60760985	0.41	MTG2	mitochondrial ribosome-associated GTPase 2	2802	0.2
chr10_50396086_50396421	0.41	C10orf128	chromosome 10 open reading frame 128	104	0.97
chrX_71342618_71342899	0.40	RGAG4	retrotransposon gag domain containing 4	8920	0.16
chr21_40181513_40181664	0.39	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	28	0.99
chr17_75142210_75142404	0.38	SEC14L1	SEC14-like 1 (S. cerevisiae)	1579	0.4
chr12_54693178_54693413	0.38	NFE2	nuclear factor, erythroid 2	1504	0.18
chr17_75462246_75462493	0.38	SEPT9	septin 9	116	0.95
chr8_96064792_96064943	0.38	ENSG00000200525	.	2575	0.23
chr3_197826796_197827012	0.38	AC073135.3		10173	0.17
chr12_54691575_54691887	0.37	NFE2	nuclear factor, erythroid 2	63	0.93
chr3_46968939_46969166	0.37	PTH1R	parathyroid hormone 1 receptor	24963	0.13
chr10_26911177_26911806	0.36	PDSS1	prenyl (decaprenyl) diphosphate synthase, subunit 1	75097	0.1
chr19_1155345_1155615	0.36	SBNO2	strawberry notch homolog 2 (Drosophila)	345	0.81
chr3_197830597_197830892	0.36	AC073135.3		6333	0.18
chr17_80817564_80818630	0.36	TBCD	tubulin folding cofactor D	173	0.94
chr22_50550352_50550703	0.35	MOV10L1	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	21842	0.11
chr16_81832397_81832594	0.34	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	19632	0.26
chr19_54784205_54784408	0.34	LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	47	0.93
chrX_65238305_65238456	0.33	ENSG00000207939	.	332	0.9
chr5_176936416_176936567	0.33	DOK3	docking protein 3	336	0.78
chr8_56792958_56793527	0.33	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	848	0.55
chr20_1471662_1471896	0.33	SIRPB2	signal-regulatory protein beta 2	263	0.87
chr16_89042423_89042673	0.33	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	853	0.55
chr1_33805040_33805319	0.32	ENSG00000222112	.	2714	0.17
chr1_17635139_17635290	0.32	PADI4	peptidyl arginine deiminase, type IV	522	0.76
chr7_73624740_73625015	0.32	LAT2	linker for activation of T cells family, member 2	524	0.74
chr6_6695474_6695863	0.32	LY86-AS1	LY86 antisense RNA 1	72664	0.12
chr21_39869780_39870199	0.32	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	356	0.93
chr19_50310817_50311209	0.32	FUZ	fuzzy planar cell polarity protein	883	0.28
chr11_10663106_10663406	0.32	MRVI1	murine retrovirus integration site 1 homolog	10476	0.19
chr4_26076892_26077043	0.32	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	88110	0.1
chr3_58339519_58339685	0.32	PXK	PX domain containing serine/threonine kinase	20569	0.17
chr1_245215310_245215673	0.32	ENSG00000251754	.	8261	0.17
chr1_156125493_156125644	0.31	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	1406	0.27
chr2_218990528_218990679	0.31	CXCR2	chemokine (C-X-C motif) receptor 2	124	0.96
chr14_105527834_105528220	0.31	GPR132	G protein-coupled receptor 132	3740	0.23
chr3_99792509_99792782	0.31	FILIP1L	filamin A interacting protein 1-like	40712	0.15
chr10_106081987_106082159	0.31	ITPRIP	inositol 1,4,5-trisphosphate receptor interacting protein	6609	0.14
chr16_89041933_89042084	0.31	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	1393	0.37
chr10_126917196_126917347	0.31	CTBP2	C-terminal binding protein 2	67641	0.13
chr6_35268574_35268725	0.31	DEF6	differentially expressed in FDCP 6 homolog (mouse)	3020	0.24
chr10_75626324_75626588	0.31	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	5844	0.13
chr1_26868114_26868336	0.30	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	1378	0.34
chr11_72449633_72449911	0.30	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	11599	0.12
chr1_26870073_26870236	0.30	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	551	0.7
chr19_55105527_55105771	0.29	LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	524	0.65
chr19_42302514_42302665	0.29	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	1504	0.28
chr12_133346878_133347204	0.29	ANKLE2	ankyrin repeat and LEM domain containing 2	8567	0.15
chr22_17598033_17598230	0.29	CECR6	cat eye syndrome chromosome region, candidate 6	4012	0.17
chr11_1328574_1328800	0.29	TOLLIP	toll interacting protein	2162	0.23
chr16_28506424_28506601	0.29	CLN3	ceroid-lipofuscinosis, neuronal 3	343	0.59
chr8_134086774_134086935	0.29	SLA	Src-like-adaptor	14251	0.23
chr6_2840053_2840204	0.29	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	1966	0.32
chr3_5019013_5019527	0.29	BHLHE40	basic helix-loop-helix family, member e40	1531	0.38
chr11_68502790_68502941	0.29	MTL5	metallothionein-like 5, testis-specific (tesmin)	16063	0.19
chr14_102677353_102677504	0.29	WDR20	WD repeat domain 20	16145	0.17
chr7_73624408_73624729	0.29	LAT2	linker for activation of T cells family, member 2	215	0.92
chr3_197827693_197827844	0.29	AC073135.3		9309	0.17
chr3_197830356_197830507	0.29	AC073135.3		6646	0.18
chr17_3820242_3820393	0.28	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	523	0.75
chr1_28502388_28502717	0.28	PTAFR	platelet-activating factor receptor	1147	0.35
chr3_197829537_197829688	0.28	AC073135.3		7465	0.18
chr20_4794055_4794206	0.28	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	1639	0.4
chr10_440689_440840	0.28	DIP2C	DIP2 disco-interacting protein 2 homolog C (Drosophila)	7015	0.21
chr2_185461919_185462338	0.28	ZNF804A	zinc finger protein 804A	965	0.73
chr3_197828427_197828578	0.28	AC073135.3		8575	0.17
chr11_65544144_65544295	0.28	AP5B1	adaptor-related protein complex 5, beta 1 subunit	4054	0.11
chr18_44181171_44181332	0.28	LOXHD1	lipoxygenase homology domains 1	228	0.96
chr4_91048244_91048537	0.28	CCSER1	coiled-coil serine-rich protein 1	346	0.94
chr17_79133696_79133927	0.28	AATK-AS1	AATK antisense RNA 1	5496	0.1
chr11_8228040_8228278	0.28	RIC3	RIC3 acetylcholine receptor chaperone	37557	0.16
chr11_47396157_47396308	0.27	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene	3710	0.12
chr1_27951514_27951705	0.27	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	1036	0.44
chr1_161600101_161600252	0.27	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	646	0.42
chr19_33783790_33784192	0.27	CTD-2540B15.11		6849	0.13
chr19_33791374_33791575	0.27	CTD-2540B15.11		634	0.4
chr17_47307213_47307364	0.27	PHOSPHO1	phosphatase, orphan 1	602	0.68
chr19_18507804_18508682	0.27	LRRC25	leucine rich repeat containing 25	178	0.89
chr10_94452035_94452186	0.27	HHEX	hematopoietically expressed homeobox	498	0.8
chr16_85793045_85793254	0.27	C16orf74	chromosome 16 open reading frame 74	8414	0.11
chr12_10280937_10281088	0.27	CLEC7A	C-type lectin domain family 7, member A	1669	0.27
chr7_101928648_101928947	0.27	SH2B2	SH2B adaptor protein 2	345	0.82
chr1_161185105_161185306	0.27	FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	118	0.89
chr16_31138973_31139124	0.26	KAT8	K(lysine) acetyltransferase 8	455	0.56
chr20_5551143_5551294	0.26	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	4936	0.28
chr3_107851409_107852101	0.26	CD47	CD47 molecule	41883	0.19
chr22_30659617_30659828	0.26	OSM	oncostatin M	2085	0.18
chr12_7067641_7067951	0.26	ENSG00000207713	.	5066	0.06
chr11_67053296_67053447	0.26	ANKRD13D	ankyrin repeat domain 13 family, member D	2647	0.17
chr10_73510613_73510786	0.26	C10orf54	chromosome 10 open reading frame 54	6688	0.2
chr1_153363293_153363489	0.26	S100A8	S100 calcium binding protein A8	61	0.95
chr9_69785762_69786779	0.26	IGKV1OR-2	immunoglobulin kappa variable 1/OR-2 (pseudogene)	8317	0.25
chr15_38334834_38334985	0.26	TMCO5A	transmembrane and coiled-coil domains 5A	107451	0.08
chr9_136208277_136208487	0.26	ENSG00000201451	.	3721	0.08
chr9_37913420_37913571	0.26	SLC25A51	solute carrier family 25, member 51	9365	0.22
chr3_197829349_197829500	0.26	AC073135.3		7653	0.18
chr4_74809740_74810515	0.26	PF4	platelet factor 4	37714	0.11
chr1_161593652_161593803	0.26	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	7095	0.12
chr7_5501942_5502166	0.25	ENSG00000238394	.	22972	0.11
chr17_79133935_79134086	0.25	AATK-AS1	AATK antisense RNA 1	5297	0.1
chr20_55950478_55950629	0.25	MTRNR2L3	MT-RNR2-like 3	15675	0.12
chr16_89003788_89003939	0.25	RP11-830F9.7		301	0.83
chr6_611280_611431	0.25	HUS1B	HUS1 checkpoint homolog b (S. pombe)	45608	0.17
chr17_76776046_76776325	0.25	CYTH1	cytohesin 1	2169	0.3
chr20_62708665_62709256	0.25	RGS19	regulator of G-protein signaling 19	1885	0.17
chr2_169939774_169939925	0.25	DHRS9	dehydrogenase/reductase (SDR family) member 9	2232	0.33
chr12_49627195_49627425	0.25	TUBA1C	tubulin, alpha 1c	5601	0.13
chr5_176732926_176733077	0.25	PRELID1	PRELI domain containing 1	1312	0.28
chr11_10627173_10627324	0.25	MRVI1-AS1	MRVI1 antisense RNA 1	12504	0.17
chr3_46248645_46248796	0.25	CCR1	chemokine (C-C motif) receptor 1	1167	0.54
chr2_71681786_71681937	0.25	DYSF	dysferlin	1009	0.63
chrX_12926467_12926618	0.25	TLR8-AS1	TLR8 antisense RNA 1	90	0.96
chr19_18134589_18135083	0.25	ARRDC2	arrestin domain containing 2	15859	0.14
chr16_434070_434221	0.25	TMEM8A	transmembrane protein 8A	2163	0.17
chr21_39867699_39867850	0.25	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	2571	0.43
chr19_52252047_52252198	0.25	FPR1	formyl peptide receptor 1	1942	0.21
chr9_95727201_95727619	0.25	FGD3	FYVE, RhoGEF and PH domain containing 3	1167	0.54
chr11_58978296_58978447	0.25	MPEG1	macrophage expressed 1	2053	0.27
chr8_25059023_25059435	0.25	DOCK5	dedicator of cytokinesis 5	16849	0.22
chr14_70120562_70120713	0.25	KIAA0247	KIAA0247	42324	0.16
chr17_2699734_2700214	0.25	RAP1GAP2	RAP1 GTPase activating protein 2	198	0.94
chr7_128048882_128049033	0.25	IMPDH1	IMP (inosine 5'-monophosphate) dehydrogenase 1	998	0.47
chr20_3994903_3996170	0.25	RNF24	ring finger protein 24	500	0.83
chr1_17446030_17446253	0.25	PADI2	peptidyl arginine deiminase, type II	193	0.94
chr19_45256119_45256273	0.25	BCL3	B-cell CLL/lymphoma 3	1618	0.24
chr4_38531163_38531332	0.25	RP11-617D20.1		94949	0.08
chr17_1548578_1548729	0.24	SCARF1	scavenger receptor class F, member 1	385	0.74
chr2_113932280_113932569	0.24	AC016683.5		490	0.59
chr1_65430726_65432146	0.24	JAK1	Janus kinase 1	751	0.73
chr14_20895899_20896050	0.24	KLHL33	kelch-like family member 33	7827	0.08
chr19_11432573_11432724	0.24	CTC-510F12.6		184	0.88
chr4_3039964_3040368	0.24	ENSG00000199335	.	5662	0.19
chr2_233926827_233927087	0.24	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	1768	0.35
chr7_50345023_50345395	0.24	IKZF1	IKAROS family zinc finger 1 (Ikaros)	831	0.74
chr10_70849708_70849969	0.24	SRGN	serglycin	1964	0.33
chr6_41168637_41168931	0.24	TREML2	triggering receptor expressed on myeloid cells-like 2	148	0.93
chr15_91428234_91428460	0.24	FES	feline sarcoma oncogene	71	0.94
chr14_77873229_77873401	0.24	FKSG61		9426	0.11
chr7_37382144_37382404	0.24	ELMO1	engulfment and cell motility 1	93	0.97
chr2_43333372_43333523	0.24	ENSG00000207087	.	14815	0.27
chr4_185781635_185781786	0.24	ENSG00000266698	.	9446	0.2
chr15_31558914_31559065	0.24	KLF13	Kruppel-like factor 13	60069	0.14
chr22_24038076_24038227	0.24	RGL4	ral guanine nucleotide dissociation stimulator-like 4	520	0.69
chrX_30594869_30596024	0.24	CXorf21	chromosome X open reading frame 21	515	0.84
chr11_3855665_3855911	0.24	RHOG	ras homolog family member G	3309	0.13
chr12_94567701_94567872	0.24	RP11-74K11.2		2394	0.32
chr12_123373053_123373596	0.24	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	1382	0.39
chr20_4791271_4791422	0.24	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	4423	0.23
chr8_56851767_56852412	0.24	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	704	0.63
chr1_150975096_150975673	0.24	FAM63A	family with sequence similarity 63, member A	3577	0.1
chr8_142288307_142288672	0.24	RP11-10J21.3	Uncharacterized protein	23825	0.12
chr2_208015092_208015258	0.24	KLF7	Kruppel-like factor 7 (ubiquitous)	15120	0.19
chr9_124115790_124115941	0.24	AL161784.1	Uncharacterized protein	12240	0.14
chr16_29756930_29757303	0.24	C16orf54	chromosome 16 open reading frame 54	211	0.73
chr2_68962051_68962936	0.24	ARHGAP25	Rho GTPase activating protein 25	479	0.86
chr22_24536224_24536535	0.24	CABIN1	calcineurin binding protein 1	15427	0.16
chr20_55059093_55059344	0.24	ENSG00000238294	.	8519	0.13
chr19_54823726_54823877	0.23	LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	543	0.6
chr10_81054866_81055072	0.23	ZMIZ1	zinc finger, MIZ-type containing 1	11006	0.24
chr3_197829008_197829159	0.23	AC073135.3		7994	0.18
chr5_176937088_176937239	0.23	DOK3	docking protein 3	220	0.87
chr12_7060685_7060854	0.23	PTPN6	protein tyrosine phosphatase, non-receptor type 6	231	0.78
chr2_113931904_113932161	0.23	PSD4	pleckstrin and Sec7 domain containing 4	458	0.63
chr4_185748277_185748428	0.23	ACSL1	acyl-CoA synthetase long-chain family member 1	380	0.86
chr17_30646004_30646155	0.23	C17orf75	chromosome 17 open reading frame 75	15483	0.14
chr2_87874283_87874487	0.23	ENSG00000265507	.	54889	0.15
chr5_131756417_131756718	0.23	AC116366.5		5579	0.14
chr14_24784022_24784248	0.23	LTB4R	leukotriene B4 receptor	229	0.8
chrX_8696930_8697081	0.23	KAL1	Kallmann syndrome 1 sequence	3222	0.37
chr9_136207992_136208143	0.23	ENSG00000201451	.	3406	0.08
chr7_22762779_22763152	0.23	IL6	interleukin 6 (interferon, beta 2)	2538	0.27
chr11_1802236_1802476	0.23	CTSD	cathepsin D	17134	0.08
chr6_6885939_6886224	0.23	ENSG00000240936	.	53049	0.17
chr2_106414895_106415184	0.23	NCK2	NCK adaptor protein 2	17976	0.25
chr17_7959293_7959452	0.23	ALOX15B	arachidonate 15-lipoxygenase, type B	16898	0.09
chr6_144480917_144481068	0.23	STX11	syntaxin 11	9329	0.26
chr10_30315881_30316032	0.23	KIAA1462	KIAA1462	32497	0.24
chr22_24938120_24938271	0.23	GUCD1	guanylyl cyclase domain containing 1	12862	0.12
chr5_177668572_177668807	0.23	PHYKPL	5-phosphohydroxy-L-lysine phospho-lyase	8903	0.2
chr1_161531648_161531799	0.23	RP11-5K23.5		4855	0.14
chr1_84903223_84903376	0.23	DNASE2B	deoxyribonuclease II beta	29386	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0001821	histamine secretion(GO:0001821)
0.1	0.3	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.4	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.1	0.1	GO:0002830	positive regulation of type 2 immune response(GO:0002830)
0.1	0.5	GO:0001820	serotonin secretion(GO:0001820)
0.1	0.4	GO:0018101	protein citrullination(GO:0018101)
0.1	0.3	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.1	0.3	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.3	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.7	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.3	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.3	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1	0.4	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.1	0.2	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.1	0.4	GO:0001878	response to yeast(GO:0001878)
0.1	0.3	GO:0002864	regulation of acute inflammatory response to antigenic stimulus(GO:0002864)
0.1	0.6	GO:0015671	oxygen transport(GO:0015671)
0.1	0.3	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.2	GO:0015809	arginine transport(GO:0015809)
0.1	0.2	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1	0.2	GO:0019372	lipoxygenase pathway(GO:0019372)
0.1	0.1	GO:0001774	microglial cell activation(GO:0001774)
0.1	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1	0.2	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	0.2	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.1	0.4	GO:0016322	neuron remodeling(GO:0016322)
0.1	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.1	0.4	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.1	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.2	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.1	0.2	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.1	0.2	GO:0045056	transcytosis(GO:0045056)
0.1	0.2	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.1	0.3	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.1	0.2	GO:0033003	regulation of mast cell activation(GO:0033003)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.7	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.5	GO:0043303	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0	0.2	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.4	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.1	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.4	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0042819	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.2	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.2	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.0	GO:0006168	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.8	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.2	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.3	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.1	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0032352	positive regulation of hormone metabolic process(GO:0032352) positive regulation of hormone biosynthetic process(GO:0046886)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.2	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.1	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.6	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.2	GO:0016114	terpenoid biosynthetic process(GO:0016114)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.1	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.0	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.3	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.1	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.3	GO:0090398	cellular senescence(GO:0090398)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.0	GO:0032011	ARF protein signal transduction(GO:0032011)
0.0	0.0	GO:0060058	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.2	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.1	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.2	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.1	GO:0045060	negative thymic T cell selection(GO:0045060)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0060456	positive regulation of digestive system process(GO:0060456)
0.0	0.3	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.1	GO:0071285	cellular response to lithium ion(GO:0071285)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.0	GO:0032760	positive regulation of tumor necrosis factor production(GO:0032760)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0060406	regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.3	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.1	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0051136	NK T cell differentiation(GO:0001865) tolerance induction to self antigen(GO:0002513) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0032627	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667)
0.0	0.1	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.2	GO:0046580	negative regulation of Ras protein signal transduction(GO:0046580)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.1	GO:0051549	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0022401	desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0	0.2	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.1	GO:0046325	negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0030656	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) regulation of vitamin metabolic process(GO:0030656) vitamin D biosynthetic process(GO:0042368) negative regulation of vitamin metabolic process(GO:0046137) regulation of vitamin D biosynthetic process(GO:0060556) regulation of calcidiol 1-monooxygenase activity(GO:0060558)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.5	GO:0030183	B cell differentiation(GO:0030183)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.0	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.3	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.1	GO:0031000	response to caffeine(GO:0031000)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0019317	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.0	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.0	GO:0036315	cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0	0.2	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.3	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.0	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0	0.1	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.1	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.6	GO:0006968	cellular defense response(GO:0006968)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.2	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0042116	macrophage activation(GO:0042116)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0060742	epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0001783	B cell apoptotic process(GO:0001783)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.2	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
0.0	0.0	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0097306	cellular response to alcohol(GO:0097306)
0.0	0.0	GO:1903299	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.1	GO:0045408	regulation of interleukin-6 biosynthetic process(GO:0045408)
0.0	0.2	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0097191	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.1	GO:0000239	pachytene(GO:0000239)
0.0	0.0	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.0	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.0	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0000076	DNA replication checkpoint(GO:0000076)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0032675	regulation of interleukin-6 production(GO:0032675)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0015669	gas transport(GO:0015669)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:1901070	guanosine-containing compound biosynthetic process(GO:1901070)
0.0	0.0	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.2	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.2	GO:0006026	aminoglycan catabolic process(GO:0006026)
0.0	0.2	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.2	GO:0035338	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.0	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0070723	response to sterol(GO:0036314) response to cholesterol(GO:0070723)
0.0	0.0	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:1903313	regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0010919	regulation of inositol phosphate biosynthetic process(GO:0010919)
0.0	0.0	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.0	GO:0052031	modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0	0.1	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.0	GO:0090151	establishment of protein localization to mitochondrial membrane(GO:0090151)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.1	GO:0015695	organic cation transport(GO:0015695)
0.0	0.1	GO:0051923	sulfation(GO:0051923)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0048205	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.0	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0051882	mitochondrial depolarization(GO:0051882)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.0	GO:0048569	post-embryonic organ development(GO:0048569)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042629	mast cell granule(GO:0042629)
0.1	0.5	GO:0030061	mitochondrial crista(GO:0030061)
0.1	0.3	GO:0044462	external encapsulating structure part(GO:0044462)
0.1	0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.2	GO:0031045	dense core granule(GO:0031045)
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.2	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.3	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0000125	PCAF complex(GO:0000125)
0.0	0.4	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.3	GO:0043209	myelin sheath(GO:0043209)
0.0	0.2	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.0	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.4	GO:0032420	stereocilium(GO:0032420)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.0	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.4	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.0	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.0	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.4	GO:0042641	actomyosin(GO:0042641)
0.0	0.0	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.8	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.7	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.0	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.5	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.6	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	0.3	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1	0.4	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.1	0.4	GO:0008518	reduced folate carrier activity(GO:0008518)
0.1	0.4	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	0.3	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0019863	IgE binding(GO:0019863)
0.1	0.2	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	0.7	GO:0019864	IgG binding(GO:0019864)
0.1	0.5	GO:0043208	glycosphingolipid binding(GO:0043208)
0.1	0.3	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.2	GO:0004875	complement receptor activity(GO:0004875)
0.1	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.2	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.1	0.5	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.1	0.2	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.3	GO:0001727	lipid kinase activity(GO:0001727)
0.1	0.3	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	0.3	GO:0004904	interferon receptor activity(GO:0004904)
0.1	0.2	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	0.2	GO:0002060	purine nucleobase binding(GO:0002060)
0.1	0.4	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.5	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.6	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.2	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.2	GO:0031014	troponin T binding(GO:0031014)
0.0	0.3	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.2	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0019956	chemokine binding(GO:0019956)
0.0	0.2	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.3	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.3	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.3	GO:0005123	death receptor binding(GO:0005123)
0.0	0.4	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	1.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.2	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.5	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.2	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.3	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.2	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.2	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	0.4	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.3	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.0	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0034979	NAD-dependent protein deacetylase activity(GO:0034979)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.0	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.2	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.4	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.3	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.1	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.0	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.0	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.1	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.0	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.0	GO:0015651	quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.3	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.0	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.1	GO:0033612	receptor serine/threonine kinase binding(GO:0033612)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.5	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.0	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.0	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.0	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.3	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	1.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.6	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.8	PID IGF1 PATHWAY	IGF1 pathway
0.0	1.3	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.1	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.6	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.0	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.2	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.2	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.3	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	0.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.5	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	1.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	1.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.5	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.0	REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK
0.0	0.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.0	0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.4	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.0	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.1	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.1	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.0	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10