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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for LEF1

Z-value: 0.98

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Transcription factors associated with LEF1

Gene Symbol	Gene ID	Gene Info
LEF1 Ensembl NCBI GeneCards UniProt	ENSG00000138795.5	LEF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
LEF1	chr4_109055624_109055775	31758	0.182969	-0.45	2.2e-01	Click!
LEF1	chr4_109062164_109062315	25218	0.197824	0.40	2.8e-01	Click!
LEF1	chr4_109076513_109076664	10869	0.226088	0.40	2.9e-01	Click!
LEF1	chr4_109012857_109013008	74525	0.091399	0.38	3.2e-01	Click!
LEF1	chr4_109037667_109037818	49715	0.140440	-0.33	3.9e-01	Click!

Activity of the LEF1 motif across conditions

Conditions sorted by the z-value of the LEF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_169652381_169652976	0.20	THBS2	thrombospondin 2	432	0.89
chr14_23447268_23447766	0.20	AJUBA	ajuba LIM protein	571	0.5
chr15_30112674_30113382	0.15	TJP1	tight junction protein 1	723	0.64
chr10_122451080_122451231	0.15	WDR11-AS1	WDR11 antisense RNA 1	85241	0.09
chr5_32985210_32985395	0.14	AC026703.1		196357	0.03
chr13_60593844_60594053	0.14	DIAPH3-AS1	DIAPH3 antisense RNA 1	6508	0.25
chr1_7439604_7439992	0.14	RP3-453P22.2		9681	0.21
chr5_175460576_175460928	0.14	THOC3	THO complex 3	931	0.5
chr14_51909906_51910057	0.14	FRMD6	FERM domain containing 6	45874	0.16
chr2_189158808_189158959	0.13	GULP1	GULP, engulfment adaptor PTB domain containing 1	338	0.89
chr16_88135173_88135324	0.13	BANP	BTG3 associated nuclear protein	131624	0.05
chr3_123699067_123699263	0.13	ROPN1	rhophilin associated tail protein 1	11034	0.2
chr4_86700210_86700446	0.13	ARHGAP24	Rho GTPase activating protein 24	469	0.88
chr2_242802004_242802249	0.13	PDCD1	programmed cell death 1	1066	0.37
chr3_192634406_192635568	0.13	MB21D2	Mab-21 domain containing 2	963	0.71
chr10_94725160_94725374	0.13	EXOC6	exocyst complex component 6	31964	0.2
chr21_32533012_32533247	0.12	TIAM1	T-cell lymphoma invasion and metastasis 1	30590	0.23
chr18_67714217_67714443	0.12	RTTN	rotatin	26376	0.25
chr4_52904501_52904984	0.12	SGCB	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)	94	0.97
chr10_105614245_105615135	0.12	SH3PXD2A	SH3 and PX domains 2A	474	0.82
chr2_24398914_24399065	0.12	FAM228A	family with sequence similarity 228, member A	635	0.51
chr4_20260773_20260924	0.12	SLIT2	slit homolog 2 (Drosophila)	4305	0.36
chr8_26165121_26165272	0.12	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	14197	0.25
chr11_26211058_26211209	0.12	ANO3	anoctamin 3	304	0.95
chr7_14417428_14417579	0.12	ENSG00000252374	.	367115	0.01
chr7_96653221_96653741	0.11	DLX5	distal-less homeobox 5	781	0.6
chr9_113530116_113530340	0.11	MUSK	muscle, skeletal, receptor tyrosine kinase	7399	0.3
chr4_140807822_140807973	0.11	MAML3	mastermind-like 3 (Drosophila)	3309	0.35
chr11_35642492_35642706	0.11	FJX1	four jointed box 1 (Drosophila)	2864	0.32
chr15_40630709_40631123	0.11	C15orf52	chromosome 15 open reading frame 52	582	0.52
chrX_66767815_66768085	0.11	AR	androgen receptor	2964	0.43
chr10_32202333_32202484	0.11	ARHGAP12	Rho GTPase activating protein 12	4606	0.3
chr15_92080010_92080161	0.11	ENSG00000238981	.	298524	0.01
chr15_96212773_96212983	0.11	ENSG00000222076	.	76155	0.13
chr5_52489907_52490058	0.11	MOCS2	molybdenum cofactor synthesis 2	84089	0.09
chr2_238318512_238318719	0.11	COL6A3	collagen, type VI, alpha 3	4176	0.24
chr2_220942198_220942388	0.11	ENSG00000221199	.	114306	0.06
chr11_64333824_64334194	0.11	SLC22A11	solute carrier family 22 (organic anion/urate transporter), member 11	1063	0.49
chr6_81938853_81939008	0.11	RP1-300G12.2		305700	0.01
chr2_11887384_11888228	0.11	LPIN1	lipin 1	1042	0.41
chr4_54581434_54581585	0.11	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	13937	0.22
chr2_12859088_12859514	0.10	TRIB2	tribbles pseudokinase 2	937	0.67
chr3_98666159_98666310	0.10	ENSG00000207331	.	38931	0.15
chrX_34673509_34673660	0.10	TMEM47	transmembrane protein 47	1821	0.53
chr3_112961154_112961680	0.10	BOC	BOC cell adhesion associated, oncogene regulated	26219	0.19
chr12_13359480_13359859	0.10	EMP1	epithelial membrane protein 1	4776	0.29
chr2_238321225_238321570	0.10	COL6A3	collagen, type VI, alpha 3	1394	0.45
chr4_158916155_158916306	0.10	FAM198B	family with sequence similarity 198, member B	164603	0.03
chr3_149356356_149356942	0.10	WWTR1-IT1	WWTR1 intronic transcript 1 (non-protein coding)	11322	0.17
chr16_73236593_73236744	0.10	C16orf47	chromosome 16 open reading frame 47	58322	0.16
chr2_58250808_58250969	0.10	VRK2	vaccinia related kinase 2	22841	0.23
chr9_4490575_4491197	0.10	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	442	0.88
chr2_15310036_15310187	0.10	NBAS	neuroblastoma amplified sequence	20410	0.29
chr18_49683791_49683942	0.10	DCC	deleted in colorectal carcinoma	182676	0.03
chr15_96869332_96869483	0.10	NR2F2	nuclear receptor subfamily 2, group F, member 2	240	0.83
chr2_119603311_119603908	0.10	EN1	engrailed homeobox 1	1645	0.51
chr10_11371205_11371471	0.10	CELF2-AS1	CELF2 antisense RNA 1	9491	0.29
chr12_110723019_110723319	0.10	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	3683	0.28
chr3_33686746_33686949	0.10	CLASP2	cytoplasmic linker associated protein 2	40	0.99
chrX_54947220_54948504	0.10	TRO	trophinin	41	0.97
chr15_97433403_97433676	0.10	ENSG00000223120	.	48240	0.17
chr18_53089837_53090372	0.10	TCF4	transcription factor 4	361	0.89
chr12_88972313_88972545	0.10	KITLG	KIT ligand	1809	0.39
chr7_137567705_137567869	0.09	DGKI	diacylglycerol kinase, iota	35949	0.17
chr10_124221611_124222138	0.09	HTRA1	HtrA serine peptidase 1	833	0.61
chr15_89181571_89183025	0.09	ISG20	interferon stimulated exonuclease gene 20kDa	114	0.96
chr6_100316163_100316348	0.09	MCHR2-AS1	MCHR2 antisense RNA 1	125565	0.05
chr5_66611355_66611669	0.09	CD180	CD180 molecule	118885	0.06
chr5_173846066_173846362	0.09	CTC-229L21.1		246110	0.02
chr1_197163991_197164285	0.09	ZBTB41	zinc finger and BTB domain containing 41	5534	0.22
chr2_36796670_36797008	0.09	FEZ2	fasciculation and elongation protein zeta 2 (zygin II)	11631	0.19
chr7_113722711_113723554	0.09	FOXP2	forkhead box P2	3483	0.3
chr13_24144563_24144801	0.09	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	121	0.98
chr6_111949604_111949832	0.09	ENSG00000239015	.	17912	0.16
chr22_23863444_23864162	0.09	AP000345.2		45448	0.12
chr20_43976437_43976958	0.09	SDC4	syndecan 4	367	0.79
chr17_42004293_42004804	0.09	RP11-527L4.5		4179	0.12
chr6_143994597_143994872	0.09	PHACTR2	phosphatase and actin regulator 2	4368	0.31
chr7_841605_841901	0.09	SUN1	Sad1 and UNC84 domain containing 1	13775	0.17
chr3_125690962_125691349	0.09	ROPN1B	rhophilin associated tail protein 1B	3098	0.23
chr15_60684685_60685107	0.09	ANXA2	annexin A2	1400	0.54
chr10_54075051_54075395	0.09	DKK1	dickkopf WNT signaling pathway inhibitor 1	1167	0.43
chr4_103737426_103737626	0.09	UBE2D3	ubiquitin-conjugating enzyme E2D 3	9173	0.15
chr10_25137198_25137349	0.09	ENSG00000240294	.	60468	0.13
chr7_27218725_27218915	0.09	RP1-170O19.20	Uncharacterized protein	812	0.27
chr8_122360745_122360896	0.09	ENSG00000221644	.	161688	0.04
chr3_159506026_159506232	0.09	IQCJ-SCHIP1-AS1	IQCJ-SCHIP1 readthrough antisense RNA 1	19728	0.15
chr17_76785896_76786047	0.09	CYTH1	cytohesin 1	7592	0.18
chr4_101342464_101342615	0.09	EMCN	endomucin	53695	0.17
chr20_51475685_51475852	0.09	TSHZ2	teashirt zinc finger homeobox 2	113178	0.07
chr16_89990293_89990742	0.09	TUBB3	Tubulin beta-3 chain	743	0.44
chr11_46670801_46671004	0.09	ATG13	autophagy related 13	10070	0.15
chr7_22536430_22536632	0.09	STEAP1B	STEAP family member 1B	3265	0.31
chr10_54079102_54079253	0.09	DKK1	dickkopf WNT signaling pathway inhibitor 1	5121	0.26
chr11_12836551_12836790	0.09	RP11-47J17.3		8544	0.22
chr10_119564055_119564206	0.09	RP11-354M20.3		212868	0.02
chr7_134464463_134465343	0.09	CALD1	caldesmon 1	474	0.89
chr4_114898942_114899097	0.09	ARSJ	arylsulfatase family, member J	1133	0.61
chr1_214397865_214398571	0.09	SMYD2	SET and MYND domain containing 2	56358	0.16
chr1_156087932_156088663	0.09	LMNA	lamin A/C	3784	0.13
chr5_169398695_169398846	0.09	FAM196B	family with sequence similarity 196, member B	8974	0.26
chr22_45607681_45607964	0.09	KIAA0930	KIAA0930	476	0.78
chr18_7579845_7579996	0.09	PTPRM	protein tyrosine phosphatase, receptor type, M	12103	0.29
chr7_115116914_115117103	0.09	ENSG00000202377	.	104488	0.08
chr2_151260036_151260226	0.09	RND3	Rho family GTPase 3	81765	0.12
chr7_100464814_100466140	0.09	TRIP6	thyroid hormone receptor interactor 6	717	0.47
chr13_110958781_110959436	0.08	COL4A1	collagen, type IV, alpha 1	370	0.6
chr9_111206334_111206588	0.08	ENSG00000222512	.	85252	0.11
chr3_149371362_149371801	0.08	WWTR1-AS1	WWTR1 antisense RNA 1	3226	0.2
chr11_130319616_130319897	0.08	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif, 15	887	0.67
chr8_142215547_142216678	0.08	DENND3	DENN/MADD domain containing 3	13682	0.16
chr3_49237110_49237583	0.08	CCDC36	coiled-coil domain containing 36	403	0.74
chr1_68280586_68280737	0.08	GNG12-AS1	GNG12 antisense RNA 1	17325	0.19
chr7_80546807_80546971	0.08	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	1610	0.56
chr4_27086932_27087083	0.08	STIM2	stromal interaction molecule 2	76912	0.12
chr8_32184476_32184627	0.08	ENSG00000200246	.	70539	0.11
chr4_79141777_79141928	0.08	FRAS1	Fraser syndrome 1	24533	0.22
chr10_33619964_33620115	0.08	NRP1	neuropilin 1	3271	0.33
chr2_237652692_237652863	0.08	ACKR3	atypical chemokine receptor 3	174493	0.03
chr10_88518871_88519024	0.08	BMPR1A	bone morphogenetic protein receptor, type IA	2540	0.23
chr5_167899041_167899382	0.08	RARS	arginyl-tRNA synthetase	14239	0.2
chr17_78699090_78699345	0.08	RP11-28G8.1		80215	0.09
chr2_20348576_20349061	0.08	ENSG00000266059	.	26289	0.15
chr17_67056652_67056803	0.08	ABCA9	ATP-binding cassette, sub-family A (ABC1), member 9	320	0.9
chr17_77223432_77223590	0.08	RBFOX3	RNA binding protein, fox-1 homolog (C. elegans) 3	8376	0.27
chr13_75018049_75018424	0.08	LINC00381	long intergenic non-protein coding RNA 381	24926	0.22
chrX_46186736_46187042	0.08	KRBOX4	KRAB box domain containing 4	119403	0.06
chr3_51377510_51377669	0.08	MANF	mesencephalic astrocyte-derived neurotrophic factor	44889	0.15
chr12_57522507_57523183	0.08	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	38	0.64
chr7_38546645_38546796	0.08	ENSG00000241756	.	24219	0.23
chr3_98603544_98603695	0.08	DCBLD2	discoidin, CUB and LCCL domain containing 2	16396	0.17
chr13_79182716_79183828	0.08	POU4F1	POU class 4 homeobox 1	5599	0.19
chr15_37180001_37180243	0.08	ENSG00000212511	.	35281	0.22
chr14_37131505_37132074	0.08	PAX9	paired box 9	10	0.98
chr20_61656853_61657255	0.08	BHLHE23	basic helix-loop-helix family, member e23	18667	0.17
chr15_61012825_61012976	0.08	ENSG00000212625	.	16068	0.2
chr9_36029255_36029406	0.08	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	7100	0.21
chr3_191047655_191048448	0.08	UTS2B	urotensin 2B	211	0.91
chr18_33878744_33878957	0.08	FHOD3	formin homology 2 domain containing 3	1051	0.65
chr20_30457693_30458808	0.08	DUSP15	dual specificity phosphatase 15	125	0.67
chr3_149686814_149687069	0.08	PFN2	profilin 2	1247	0.4
chr3_112358958_112359194	0.08	CCDC80	coiled-coil domain containing 80	1040	0.62
chr3_156794251_156794402	0.08	ENSG00000222499	.	59195	0.11
chr12_80663224_80663505	0.08	OTOGL	otogelin-like	60131	0.13
chr5_35797219_35797401	0.08	SPEF2	sperm flagellar 2	18040	0.19
chr5_158203015_158203166	0.08	CTD-2363C16.1		206924	0.02
chr12_47358106_47358377	0.08	PCED1B	PC-esterase domain containing 1B	115145	0.06
chr2_38828054_38829790	0.08	AC011247.3		182	0.89
chr11_65158052_65158759	0.08	FRMD8	FERM domain containing 8	4006	0.13
chr6_140323383_140323534	0.08	ENSG00000252107	.	156373	0.04
chr8_17611273_17611424	0.08	MTUS1	microtubule associated tumor suppressor 1	2142	0.28
chr12_12972772_12973017	0.08	DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	6600	0.18
chrX_45661389_45661688	0.08	ENSG00000207725	.	55008	0.14
chr1_216705124_216705304	0.08	USH2A	Usher syndrome 2A (autosomal recessive, mild)	108476	0.08
chr5_9544374_9544669	0.08	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	1666	0.36
chr5_102096978_102097129	0.08	PAM	peptidylglycine alpha-amidating monooxygenase	6006	0.34
chr9_21576816_21576971	0.08	MIR31HG	MIR31 host gene (non-protein coding)	17225	0.18
chr6_154650904_154651062	0.08	IPCEF1	interaction protein for cytohesin exchange factors 1	232	0.96
chr6_6331737_6331888	0.08	F13A1	coagulation factor XIII, A1 polypeptide	10566	0.3
chr1_195022621_195022810	0.08	ENSG00000265108	.	73096	0.14
chr2_182819535_182819810	0.08	PPP1R1C	protein phosphatase 1, regulatory (inhibitor) subunit 1C	30879	0.17
chr4_138451566_138451717	0.08	PCDH18	protocadherin 18	1924	0.52
chr4_24472696_24473642	0.08	ENSG00000265001	.	41714	0.15
chr17_57704803_57704954	0.08	CLTC	clathrin, heavy chain (Hc)	7585	0.21
chr5_174178214_174178699	0.08	ENSG00000266890	.	281	0.94
chr2_187214072_187214223	0.08	ZC3H15	zinc finger CCCH-type containing 15	136736	0.05
chr12_6310274_6310804	0.08	CD9	CD9 molecule	576	0.75
chr4_128424253_128424404	0.08	INTU	inturned planar cell polarity protein	120098	0.06
chr6_167171492_167171681	0.08	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	187	0.97
chr9_134282757_134283214	0.08	PRRC2B	proline-rich coiled-coil 2B	13505	0.2
chr15_57946603_57946754	0.08	MYZAP	myocardial zonula adherens protein	20816	0.22
chr5_53753293_53753597	0.08	HSPB3	heat shock 27kDa protein 3	2000	0.44
chr10_79647530_79647963	0.08	AL391421.1	Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964	21113	0.15
chr10_14051355_14052213	0.08	FRMD4A	FERM domain containing 4A	1252	0.51
chr10_13931045_13931263	0.08	FRMD4A	FERM domain containing 4A	30242	0.2
chr2_74606600_74607395	0.08	DCTN1	dynactin 1	413	0.73
chr18_32291325_32291476	0.08	DTNA	dystrobrevin, alpha	1139	0.62
chr6_106207677_106207828	0.08	ENSG00000200198	.	144496	0.05
chr13_21287159_21287369	0.08	ENSG00000265710	.	9422	0.2
chr15_67021750_67022170	0.08	SMAD6	SMAD family member 6	17925	0.24
chr1_216897072_216897310	0.08	ESRRG	estrogen-related receptor gamma	396	0.93
chr17_59882538_59882689	0.08	BRIP1	BRCA1 interacting protein C-terminal helicase 1	28772	0.2
chr12_57527559_57527864	0.08	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	1789	0.2
chr4_30724120_30724271	0.08	PCDH7	protocadherin 7	218	0.97
chr9_112091327_112091518	0.08	ENSG00000207329	.	4457	0.22
chr18_56528219_56528370	0.08	ZNF532	zinc finger protein 532	1538	0.39
chr3_29377379_29377667	0.08	ENSG00000216169	.	33389	0.18
chr12_114841509_114841660	0.08	TBX5	T-box 5	119	0.97
chr21_28214648_28215240	0.08	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	393	0.9
chr17_78166034_78166254	0.08	CARD14	caspase recruitment domain family, member 14	8170	0.14
chr16_67282110_67283381	0.07	SLC9A5	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	108	0.89
chr10_52835110_52835261	0.07	PRKG1	protein kinase, cGMP-dependent, type I	1251	0.52
chr22_46479348_46479691	0.07	FLJ27365	hsa-mir-4763	2364	0.16
chr7_55089056_55089207	0.07	EGFR	epidermal growth factor receptor	2320	0.44
chr15_34728474_34728854	0.07	GOLGA8A	golgin A8 family, member A	28776	0.13
chr9_18476160_18476529	0.07	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr16_29151612_29151763	0.07	CTB-134H23.3		32921	0.13
chr9_14348492_14348672	0.07	RP11-120J1.1		1263	0.57
chr1_178096168_178096398	0.07	RASAL2	RAS protein activator like 2	33007	0.24
chr10_14050350_14050950	0.07	FRMD4A	FERM domain containing 4A	118	0.97

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0003207	cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0032650	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.0	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0009648	photoperiodism(GO:0009648)
0.0	0.1	GO:0002829	negative regulation of type 2 immune response(GO:0002829)
0.0	0.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.1	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:0090036	regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:1904238	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:1901890	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.2	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.0	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.2	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0033088	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.2	GO:0007566	embryo implantation(GO:0007566)
0.0	0.0	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.0	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.3	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.0	GO:0044217	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.4	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.0	GO:0001940	male pronucleus(GO:0001940)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0043256	laminin complex(GO:0043256)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.0	GO:0071437	invadopodium(GO:0071437)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.0	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.1	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.0	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
1.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation