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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for LEF1

Z-value: 0.98

Motif logo

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 lymphoid enhancer binding factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_109055624_109055775LEF1317580.182969-0.452.2e-01Click!
chr4_109062164_109062315LEF1252180.1978240.402.8e-01Click!
chr4_109076513_109076664LEF1108690.2260880.402.9e-01Click!
chr4_109012857_109013008LEF1745250.0913990.383.2e-01Click!
chr4_109037667_109037818LEF1497150.140440-0.333.9e-01Click!

Activity of the LEF1 motif across conditions

Conditions sorted by the z-value of the LEF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_169652381_169652976 0.20 THBS2
 thrombospondin 2
 432
 0.89
chr14_23447268_23447766 0.20 AJUBA
 ajuba LIM protein
 571
 0.5
chr15_30112674_30113382 0.15 TJP1
 tight junction protein 1
 723
 0.64
chr10_122451080_122451231 0.15 WDR11-AS1
 WDR11 antisense RNA 1
 85241
 0.09
chr5_32985210_32985395 0.14 AC026703.1
196357
 0.03
chr13_60593844_60594053 0.14 DIAPH3-AS1
 DIAPH3 antisense RNA 1
 6508
 0.25
chr1_7439604_7439992 0.14 RP3-453P22.2
9681
 0.21
chr5_175460576_175460928 0.14 THOC3
 THO complex 3
 931
 0.5
chr14_51909906_51910057 0.14 FRMD6
 FERM domain containing 6
 45874
 0.16
chr2_189158808_189158959 0.13 GULP1
 GULP, engulfment adaptor PTB domain containing 1
 338
 0.89
chr16_88135173_88135324 0.13 BANP
 BTG3 associated nuclear protein
 131624
 0.05
chr3_123699067_123699263 0.13 ROPN1
 rhophilin associated tail protein 1
 11034
 0.2
chr4_86700210_86700446 0.13 ARHGAP24
 Rho GTPase activating protein 24
 469
 0.88
chr2_242802004_242802249 0.13 PDCD1
 programmed cell death 1
 1066
 0.37
chr3_192634406_192635568 0.13 MB21D2
 Mab-21 domain containing 2
 963
 0.71
chr10_94725160_94725374 0.13 EXOC6
 exocyst complex component 6
 31964
 0.2
chr21_32533012_32533247 0.12 TIAM1
 T-cell lymphoma invasion and metastasis 1
 30590
 0.23
chr18_67714217_67714443 0.12 RTTN
 rotatin
 26376
 0.25
chr4_52904501_52904984 0.12 SGCB
 sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
 94
 0.97
chr10_105614245_105615135 0.12 SH3PXD2A
 SH3 and PX domains 2A
 474
 0.82
chr2_24398914_24399065 0.12 FAM228A
 family with sequence similarity 228, member A
 635
 0.51
chr4_20260773_20260924 0.12 SLIT2
 slit homolog 2 (Drosophila)
 4305
 0.36
chr8_26165121_26165272 0.12 PPP2R2A
 protein phosphatase 2, regulatory subunit B, alpha
 14197
 0.25
chr11_26211058_26211209 0.12 ANO3
 anoctamin 3
 304
 0.95
chr7_14417428_14417579 0.12 ENSG00000252374
 .
 367115
 0.01
chr7_96653221_96653741 0.11 DLX5
 distal-less homeobox 5
 781
 0.6
chr9_113530116_113530340 0.11 MUSK
 muscle, skeletal, receptor tyrosine kinase
 7399
 0.3
chr4_140807822_140807973 0.11 MAML3
 mastermind-like 3 (Drosophila)
 3309
 0.35
chr11_35642492_35642706 0.11 FJX1
 four jointed box 1 (Drosophila)
 2864
 0.32
chr15_40630709_40631123 0.11 C15orf52
 chromosome 15 open reading frame 52
 582
 0.52
chrX_66767815_66768085 0.11 AR
 androgen receptor
 2964
 0.43
chr10_32202333_32202484 0.11 ARHGAP12
 Rho GTPase activating protein 12
 4606
 0.3
chr15_92080010_92080161 0.11 ENSG00000238981
 .
 298524
 0.01
chr15_96212773_96212983 0.11 ENSG00000222076
 .
 76155
 0.13
chr5_52489907_52490058 0.11 MOCS2
 molybdenum cofactor synthesis 2
 84089
 0.09
chr2_238318512_238318719 0.11 COL6A3
 collagen, type VI, alpha 3
 4176
 0.24
chr2_220942198_220942388 0.11 ENSG00000221199
 .
 114306
 0.06
chr11_64333824_64334194 0.11 SLC22A11
 solute carrier family 22 (organic anion/urate transporter), member 11
 1063
 0.49
chr6_81938853_81939008 0.11 RP1-300G12.2
305700
 0.01
chr2_11887384_11888228 0.11 LPIN1
 lipin 1
 1042
 0.41
chr4_54581434_54581585 0.11 LNX1
 ligand of numb-protein X 1, E3 ubiquitin protein ligase
 13937
 0.22
chr2_12859088_12859514 0.10 TRIB2
 tribbles pseudokinase 2
 937
 0.67
chr3_98666159_98666310 0.10 ENSG00000207331
 .
 38931
 0.15
chrX_34673509_34673660 0.10 TMEM47
 transmembrane protein 47
 1821
 0.53
chr3_112961154_112961680 0.10 BOC
 BOC cell adhesion associated, oncogene regulated
 26219
 0.19
chr12_13359480_13359859 0.10 EMP1
 epithelial membrane protein 1
 4776
 0.29
chr2_238321225_238321570 0.10 COL6A3
 collagen, type VI, alpha 3
 1394
 0.45
chr4_158916155_158916306 0.10 FAM198B
 family with sequence similarity 198, member B
 164603
 0.03
chr3_149356356_149356942 0.10 WWTR1-IT1
 WWTR1 intronic transcript 1 (non-protein coding)
 11322
 0.17
chr16_73236593_73236744 0.10 C16orf47
 chromosome 16 open reading frame 47
 58322
 0.16
chr2_58250808_58250969 0.10 VRK2
 vaccinia related kinase 2
 22841
 0.23
chr9_4490575_4491197 0.10 SLC1A1
 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
 442
 0.88
chr2_15310036_15310187 0.10 NBAS
 neuroblastoma amplified sequence
 20410
 0.29
chr18_49683791_49683942 0.10 DCC
 deleted in colorectal carcinoma
 182676
 0.03
chr15_96869332_96869483 0.10 NR2F2
 nuclear receptor subfamily 2, group F, member 2
 240
 0.83
chr2_119603311_119603908 0.10 EN1
 engrailed homeobox 1
 1645
 0.51
chr10_11371205_11371471 0.10 CELF2-AS1
 CELF2 antisense RNA 1
 9491
 0.29
chr12_110723019_110723319 0.10 ATP2A2
 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
 3683
 0.28
chr3_33686746_33686949 0.10 CLASP2
 cytoplasmic linker associated protein 2
 40
 0.99
chrX_54947220_54948504 0.10 TRO
 trophinin
 41
 0.97
chr15_97433403_97433676 0.10 ENSG00000223120
 .
 48240
 0.17
chr18_53089837_53090372 0.10 TCF4
 transcription factor 4
 361
 0.89
chr12_88972313_88972545 0.10 KITLG
 KIT ligand
 1809
 0.39
chr7_137567705_137567869 0.09 DGKI
 diacylglycerol kinase, iota
 35949
 0.17
chr10_124221611_124222138 0.09 HTRA1
 HtrA serine peptidase 1
 833
 0.61
chr15_89181571_89183025 0.09 ISG20
 interferon stimulated exonuclease gene 20kDa
 114
 0.96
chr6_100316163_100316348 0.09 MCHR2-AS1
 MCHR2 antisense RNA 1
 125565
 0.05
chr5_66611355_66611669 0.09 CD180
 CD180 molecule
 118885
 0.06
chr5_173846066_173846362 0.09 CTC-229L21.1
246110
 0.02
chr1_197163991_197164285 0.09 ZBTB41
 zinc finger and BTB domain containing 41
 5534
 0.22
chr2_36796670_36797008 0.09 FEZ2
 fasciculation and elongation protein zeta 2 (zygin II)
 11631
 0.19
chr7_113722711_113723554 0.09 FOXP2
 forkhead box P2
 3483
 0.3
chr13_24144563_24144801 0.09 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 121
 0.98
chr6_111949604_111949832 0.09 ENSG00000239015
 .
 17912
 0.16
chr22_23863444_23864162 0.09 AP000345.2
45448
 0.12
chr20_43976437_43976958 0.09 SDC4
 syndecan 4
 367
 0.79
chr17_42004293_42004804 0.09 RP11-527L4.5
4179
 0.12
chr6_143994597_143994872 0.09 PHACTR2
 phosphatase and actin regulator 2
 4368
 0.31
chr7_841605_841901 0.09 SUN1
 Sad1 and UNC84 domain containing 1
 13775
 0.17
chr3_125690962_125691349 0.09 ROPN1B
 rhophilin associated tail protein 1B
 3098
 0.23
chr15_60684685_60685107 0.09 ANXA2
 annexin A2
 1400
 0.54
chr10_54075051_54075395 0.09 DKK1
 dickkopf WNT signaling pathway inhibitor 1
 1167
 0.43
chr4_103737426_103737626 0.09 UBE2D3
 ubiquitin-conjugating enzyme E2D 3
 9173
 0.15
chr10_25137198_25137349 0.09 ENSG00000240294
 .
 60468
 0.13
chr7_27218725_27218915 0.09 RP1-170O19.20
 Uncharacterized protein
 812
 0.27
chr8_122360745_122360896 0.09 ENSG00000221644
 .
 161688
 0.04
chr3_159506026_159506232 0.09 IQCJ-SCHIP1-AS1
 IQCJ-SCHIP1 readthrough antisense RNA 1
 19728
 0.15
chr17_76785896_76786047 0.09 CYTH1
 cytohesin 1
 7592
 0.18
chr4_101342464_101342615 0.09 EMCN
 endomucin
 53695
 0.17
chr20_51475685_51475852 0.09 TSHZ2
 teashirt zinc finger homeobox 2
 113178
 0.07
chr16_89990293_89990742 0.09 TUBB3
 Tubulin beta-3 chain
 743
 0.44
chr11_46670801_46671004 0.09 ATG13
 autophagy related 13
 10070
 0.15
chr7_22536430_22536632 0.09 STEAP1B
 STEAP family member 1B
 3265
 0.31
chr10_54079102_54079253 0.09 DKK1
 dickkopf WNT signaling pathway inhibitor 1
 5121
 0.26
chr11_12836551_12836790 0.09 RP11-47J17.3
8544
 0.22
chr10_119564055_119564206 0.09 RP11-354M20.3
212868
 0.02
chr7_134464463_134465343 0.09 CALD1
 caldesmon 1
 474
 0.89
chr4_114898942_114899097 0.09 ARSJ
 arylsulfatase family, member J
 1133
 0.61
chr1_214397865_214398571 0.09 SMYD2
 SET and MYND domain containing 2
 56358
 0.16
chr1_156087932_156088663 0.09 LMNA
 lamin A/C
 3784
 0.13
chr5_169398695_169398846 0.09 FAM196B
 family with sequence similarity 196, member B
 8974
 0.26
chr22_45607681_45607964 0.09 KIAA0930
 KIAA0930
 476
 0.78
chr18_7579845_7579996 0.09 PTPRM
 protein tyrosine phosphatase, receptor type, M
 12103
 0.29
chr7_115116914_115117103 0.09 ENSG00000202377
 .
 104488
 0.08
chr2_151260036_151260226 0.09 RND3
 Rho family GTPase 3
 81765
 0.12
chr7_100464814_100466140 0.09 TRIP6
 thyroid hormone receptor interactor 6
 717
 0.47
chr13_110958781_110959436 0.08 COL4A1
 collagen, type IV, alpha 1
 370
 0.6
chr9_111206334_111206588 0.08 ENSG00000222512
 .
 85252
 0.11
chr3_149371362_149371801 0.08 WWTR1-AS1
 WWTR1 antisense RNA 1
 3226
 0.2
chr11_130319616_130319897 0.08 ADAMTS15
 ADAM metallopeptidase with thrombospondin type 1 motif, 15
 887
 0.67
chr8_142215547_142216678 0.08 DENND3
 DENN/MADD domain containing 3
 13682
 0.16
chr3_49237110_49237583 0.08 CCDC36
 coiled-coil domain containing 36
 403
 0.74
chr1_68280586_68280737 0.08 GNG12-AS1
 GNG12 antisense RNA 1
 17325
 0.19
chr7_80546807_80546971 0.08 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 1610
 0.56
chr4_27086932_27087083 0.08 STIM2
 stromal interaction molecule 2
 76912
 0.12
chr8_32184476_32184627 0.08 ENSG00000200246
 .
 70539
 0.11
chr4_79141777_79141928 0.08 FRAS1
 Fraser syndrome 1
 24533
 0.22
chr10_33619964_33620115 0.08 NRP1
 neuropilin 1
 3271
 0.33
chr2_237652692_237652863 0.08 ACKR3
 atypical chemokine receptor 3
 174493
 0.03
chr10_88518871_88519024 0.08 BMPR1A
 bone morphogenetic protein receptor, type IA
 2540
 0.23
chr5_167899041_167899382 0.08 RARS
 arginyl-tRNA synthetase
 14239
 0.2
chr17_78699090_78699345 0.08 RP11-28G8.1
80215
 0.09
chr2_20348576_20349061 0.08 ENSG00000266059
 .
 26289
 0.15
chr17_67056652_67056803 0.08 ABCA9
 ATP-binding cassette, sub-family A (ABC1), member 9
 320
 0.9
chr17_77223432_77223590 0.08 RBFOX3
 RNA binding protein, fox-1 homolog (C. elegans) 3
 8376
 0.27
chr13_75018049_75018424 0.08 LINC00381
 long intergenic non-protein coding RNA 381
 24926
 0.22
chrX_46186736_46187042 0.08 KRBOX4
 KRAB box domain containing 4
 119403
 0.06
chr3_51377510_51377669 0.08 MANF
 mesencephalic astrocyte-derived neurotrophic factor
 44889
 0.15
chr12_57522507_57523183 0.08 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
 38
 0.64
chr7_38546645_38546796 0.08 ENSG00000241756
 .
 24219
 0.23
chr3_98603544_98603695 0.08 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 16396
 0.17
chr13_79182716_79183828 0.08 POU4F1
 POU class 4 homeobox 1
 5599
 0.19
chr15_37180001_37180243 0.08 ENSG00000212511
 .
 35281
 0.22
chr14_37131505_37132074 0.08 PAX9
 paired box 9
 10
 0.98
chr20_61656853_61657255 0.08 BHLHE23
 basic helix-loop-helix family, member e23
 18667
 0.17
chr15_61012825_61012976 0.08 ENSG00000212625
 .
 16068
 0.2
chr9_36029255_36029406 0.08 RECK
 reversion-inducing-cysteine-rich protein with kazal motifs
 7100
 0.21
chr3_191047655_191048448 0.08 UTS2B
 urotensin 2B
 211
 0.91
chr18_33878744_33878957 0.08 FHOD3
 formin homology 2 domain containing 3
 1051
 0.65
chr20_30457693_30458808 0.08 DUSP15
 dual specificity phosphatase 15
 125
 0.67
chr3_149686814_149687069 0.08 PFN2
 profilin 2
 1247
 0.4
chr3_112358958_112359194 0.08 CCDC80
 coiled-coil domain containing 80
 1040
 0.62
chr3_156794251_156794402 0.08 ENSG00000222499
 .
 59195
 0.11
chr12_80663224_80663505 0.08 OTOGL
 otogelin-like
 60131
 0.13
chr5_35797219_35797401 0.08 SPEF2
 sperm flagellar 2
 18040
 0.19
chr5_158203015_158203166 0.08 CTD-2363C16.1
206924
 0.02
chr12_47358106_47358377 0.08 PCED1B
 PC-esterase domain containing 1B
 115145
 0.06
chr2_38828054_38829790 0.08 AC011247.3
182
 0.89
chr11_65158052_65158759 0.08 FRMD8
 FERM domain containing 8
 4006
 0.13
chr6_140323383_140323534 0.08 ENSG00000252107
 .
 156373
 0.04
chr8_17611273_17611424 0.08 MTUS1
 microtubule associated tumor suppressor 1
 2142
 0.28
chr12_12972772_12973017 0.08 DDX47
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
 6600
 0.18
chrX_45661389_45661688 0.08 ENSG00000207725
 .
 55008
 0.14
chr1_216705124_216705304 0.08 USH2A
 Usher syndrome 2A (autosomal recessive, mild)
 108476
 0.08
chr5_9544374_9544669 0.08 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 1666
 0.36
chr5_102096978_102097129 0.08 PAM
 peptidylglycine alpha-amidating monooxygenase
 6006
 0.34
chr9_21576816_21576971 0.08 MIR31HG
 MIR31 host gene (non-protein coding)
 17225
 0.18
chr6_154650904_154651062 0.08 IPCEF1
 interaction protein for cytohesin exchange factors 1
 232
 0.96
chr6_6331737_6331888 0.08 F13A1
 coagulation factor XIII, A1 polypeptide
 10566
 0.3
chr1_195022621_195022810 0.08 ENSG00000265108
 .
 73096
 0.14
chr2_182819535_182819810 0.08 PPP1R1C
 protein phosphatase 1, regulatory (inhibitor) subunit 1C
 30879
 0.17
chr4_138451566_138451717 0.08 PCDH18
 protocadherin 18
 1924
 0.52
chr4_24472696_24473642 0.08 ENSG00000265001
 .
 41714
 0.15
chr17_57704803_57704954 0.08 CLTC
 clathrin, heavy chain (Hc)
 7585
 0.21
chr5_174178214_174178699 0.08 ENSG00000266890
 .
 281
 0.94
chr2_187214072_187214223 0.08 ZC3H15
 zinc finger CCCH-type containing 15
 136736
 0.05
chr12_6310274_6310804 0.08 CD9
 CD9 molecule
 576
 0.75
chr4_128424253_128424404 0.08 INTU
 inturned planar cell polarity protein
 120098
 0.06
chr6_167171492_167171681 0.08 RPS6KA2
 ribosomal protein S6 kinase, 90kDa, polypeptide 2
 187
 0.97
chr9_134282757_134283214 0.08 PRRC2B
 proline-rich coiled-coil 2B
 13505
 0.2
chr15_57946603_57946754 0.08 MYZAP
 myocardial zonula adherens protein
 20816
 0.22
chr5_53753293_53753597 0.08 HSPB3
 heat shock 27kDa protein 3
 2000
 0.44
chr10_79647530_79647963 0.08 AL391421.1
 Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964
 21113
 0.15
chr10_14051355_14052213 0.08 FRMD4A
 FERM domain containing 4A
 1252
 0.51
chr10_13931045_13931263 0.08 FRMD4A
 FERM domain containing 4A
 30242
 0.2
chr2_74606600_74607395 0.08 DCTN1
 dynactin 1
 413
 0.73
chr18_32291325_32291476 0.08 DTNA
 dystrobrevin, alpha
 1139
 0.62
chr6_106207677_106207828 0.08 ENSG00000200198
 .
 144496
 0.05
chr13_21287159_21287369 0.08 ENSG00000265710
 .
 9422
 0.2
chr15_67021750_67022170 0.08 SMAD6
 SMAD family member 6
 17925
 0.24
chr1_216897072_216897310 0.08 ESRRG
 estrogen-related receptor gamma
 396
 0.93
chr17_59882538_59882689 0.08 BRIP1
 BRCA1 interacting protein C-terminal helicase 1
 28772
 0.2
chr12_57527559_57527864 0.08 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
 1789
 0.2
chr4_30724120_30724271 0.08 PCDH7
 protocadherin 7
 218
 0.97
chr9_112091327_112091518 0.08 ENSG00000207329
 .
 4457
 0.22
chr18_56528219_56528370 0.08 ZNF532
 zinc finger protein 532
 1538
 0.39
chr3_29377379_29377667 0.08 ENSG00000216169
 .
 33389
 0.18
chr12_114841509_114841660 0.08 TBX5
 T-box 5
 119
 0.97
chr21_28214648_28215240 0.08 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 393
 0.9
chr17_78166034_78166254 0.08 CARD14
 caspase recruitment domain family, member 14
 8170
 0.14
chr16_67282110_67283381 0.07 SLC9A5
 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
 108
 0.89
chr10_52835110_52835261 0.07 PRKG1
 protein kinase, cGMP-dependent, type I
 1251
 0.52
chr22_46479348_46479691 0.07 FLJ27365
 hsa-mir-4763
 2364
 0.16
chr7_55089056_55089207 0.07 EGFR
 epidermal growth factor receptor
 2320
 0.44
chr15_34728474_34728854 0.07 GOLGA8A
 golgin A8 family, member A
 28776
 0.13
chr9_18476160_18476529 0.07 ADAMTSL1
 ADAMTS-like 1
 2113
 0.45
chr16_29151612_29151763 0.07 CTB-134H23.3
32921
 0.13
chr9_14348492_14348672 0.07 RP11-120J1.1
1263
 0.57
chr1_178096168_178096398 0.07 RASAL2
 RAS protein activator like 2
 33007
 0.24
chr10_14050350_14050950 0.07 FRMD4A
 FERM domain containing 4A
 118
 0.97

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.2 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.2 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0035844 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.1 GO:0003207 cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.0 GO:0043301 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.1 GO:0060174 limb bud formation(GO:0060174)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0009648 photoperiodism(GO:0009648)
0.0 0.1 GO:0002829 negative regulation of type 2 immune response(GO:0002829)
0.0 0.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.0 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.0 0.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:1904238 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:1901890 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.0 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.0 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0033088 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.0 GO:0010107 potassium ion import(GO:0010107)
0.0 0.0 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.2 GO:0007566 embryo implantation(GO:0007566)
0.0 0.0 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.0 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0044217 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.0 GO:0001940 male pronucleus(GO:0001940)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.0 GO:0043256 laminin complex(GO:0043256)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.0 GO:0071437 invadopodium(GO:0071437)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.3 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.0 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.0 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.0 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.0 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.0 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.0 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation