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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for LHX3

Z-value: 1.23

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Transcription factors associated with LHX3

Gene Symbol	Gene ID	Gene Info
LHX3 Ensembl NCBI GeneCards UniProt	ENSG00000107187.11	LHX3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
LHX3	chr9_139091429_139091580	3500	0.229468	0.15	6.9e-01	Click!
LHX3	chr9_139090516_139090790	4351	0.212434	-0.00	1.0e+00	Click!

Activity of the LHX3 motif across conditions

Conditions sorted by the z-value of the LHX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_41215270_41215769	1.01	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	956	0.59
chr8_116675050_116675578	0.98	TRPS1	trichorhinophalangeal syndrome I	1409	0.6
chr9_89952337_89952906	0.96	ENSG00000212421	.	77256	0.11
chr12_66286178_66286489	0.75	RP11-366L20.2	Uncharacterized protein	10386	0.18
chr11_122311553_122311819	0.74	ENSG00000252776	.	8232	0.23
chr17_35851874_35852313	0.73	DUSP14	dual specificity phosphatase 14	523	0.79
chr3_79066759_79066910	0.72	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	860	0.75
chr6_27060216_27060434	0.71	ENSG00000222800	.	17434	0.13
chrX_114829080_114829277	0.70	PLS3	plastin 3	1313	0.48
chr7_98970111_98970529	0.70	ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	1552	0.28
chr18_42313149_42313495	0.70	SETBP1	SET binding protein 1	36193	0.24
chr6_147234783_147235185	0.69	STXBP5-AS1	STXBP5 antisense RNA 1	2037	0.48
chr3_33318777_33319866	0.67	FBXL2	F-box and leucine-rich repeat protein 2	353	0.91
chr20_46412966_46413363	0.66	SULF2	sulfatase 2	1069	0.59
chr4_108746841_108747185	0.65	SGMS2	sphingomyelin synthase 2	649	0.76
chr4_140808579_140808865	0.64	MAML3	mastermind-like 3 (Drosophila)	2484	0.4
chr10_33798417_33798757	0.64	NRP1	neuropilin 1	173397	0.03
chr9_97812256_97812766	0.64	ENSG00000207563	.	34979	0.12
chr13_80912572_80913077	0.62	SPRY2	sprouty homolog 2 (Drosophila)	970	0.67
chr3_60921693_60921844	0.62	ENSG00000212211	.	79491	0.12
chr12_104443157_104443419	0.60	GLT8D2	glycosyltransferase 8 domain containing 2	626	0.69
chr3_120168709_120169860	0.60	FSTL1	follistatin-like 1	554	0.84
chrX_139792263_139792666	0.60	LINC00632	long intergenic non-protein coding RNA 632	532	0.82
chr19_52452059_52452669	0.59	HCCAT3	hepatocellular carcinoma associated transcript 3 (non-protein coding)	23	0.96
chr1_120191467_120191618	0.57	ZNF697	zinc finger protein 697	1146	0.52
chr12_109116833_109117152	0.55	CORO1C	coronin, actin binding protein, 1C	7335	0.16
chr5_120114861_120115414	0.55	ENSG00000222609	.	68602	0.14
chr8_108506884_108507225	0.54	ANGPT1	angiopoietin 1	169	0.98
chr3_12235413_12235694	0.54	TIMP4	TIMP metallopeptidase inhibitor 4	34702	0.2
chrX_39548256_39548819	0.54	ENSG00000263730	.	28067	0.24
chr5_124748322_124748473	0.54	ENSG00000222107	.	61573	0.16
chr13_24146066_24146217	0.54	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	1338	0.59
chr4_25238162_25238313	0.53	PI4K2B	phosphatidylinositol 4-kinase type 2 beta	2640	0.35
chr11_111849006_111849202	0.53	DIXDC1	DIX domain containing 1	1071	0.39
chr8_107738861_107739281	0.53	OXR1	oxidation resistance 1	658	0.71
chr5_1883178_1883404	0.53	IRX4	iroquois homeobox 4	411	0.66
chr18_53089837_53090372	0.53	TCF4	transcription factor 4	361	0.89
chr1_245361051_245361416	0.53	RP11-62I21.1		36570	0.15
chr13_79182716_79183828	0.52	POU4F1	POU class 4 homeobox 1	5599	0.19
chr3_100785098_100785499	0.52	ABI3BP	ABI family, member 3 (NESH) binding protein	72939	0.11
chr11_89113858_89114276	0.51	NOX4	NADPH oxidase 4	109833	0.07
chr6_28442401_28443147	0.51	ZSCAN23	zinc finger and SCAN domain containing 23	31530	0.13
chr14_52821573_52821780	0.51	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	40563	0.18
chr7_28726429_28726958	0.51	CREB5	cAMP responsive element binding protein 5	1095	0.68
chr1_64197696_64197847	0.51	ROR1	receptor tyrosine kinase-like orphan receptor 1	41922	0.17
chr14_75039149_75039311	0.51	LTBP2	latent transforming growth factor beta binding protein 2	39545	0.13
chr22_18575359_18575510	0.51	XXbac-B476C20.9		13784	0.14
chr4_54424539_54424751	0.51	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	261	0.93
chr13_45242490_45242715	0.49	ENSG00000238932	.	39793	0.2
chr10_33621519_33621932	0.49	NRP1	neuropilin 1	1585	0.49
chr9_93557702_93558119	0.49	SYK	spleen tyrosine kinase	6159	0.34
chr15_99444137_99444307	0.49	RP11-654A16.1		7458	0.22
chr2_164590425_164590732	0.49	FIGN	fidgetin	1939	0.52
chr5_72327202_72327380	0.48	ENSG00000200833	.	68609	0.09
chr7_110879115_110879283	0.48	ENSG00000238922	.	129786	0.05
chr16_53244996_53245358	0.48	CHD9	chromodomain helicase DNA binding protein 9	2814	0.29
chr14_75038296_75038530	0.48	LTBP2	latent transforming growth factor beta binding protein 2	40362	0.13
chr15_45940670_45940821	0.48	SQRDL	sulfide quinone reductase-like (yeast)	2666	0.28
chr1_182365770_182365966	0.48	TEDDM1	transmembrane epididymal protein 1	3883	0.23
chr2_38295840_38295991	0.47	RMDN2-AS1	RMDN2 antisense RNA 1	1731	0.34
chr7_17720120_17720505	0.47	SNX13	sorting nexin 13	259779	0.02
chr5_57134719_57134870	0.47	ENSG00000266864	.	34079	0.24
chr5_173000019_173000195	0.47	CTB-33O18.3		6539	0.26
chr10_62335914_62336175	0.44	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	3623	0.38
chr5_54456050_54456451	0.44	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr13_97930897_97931108	0.44	MBNL2	muscleblind-like splicing regulator 2	2544	0.4
chr16_53809887_53810055	0.43	FTO	fat mass and obesity associated	71877	0.11
chr11_35642709_35642958	0.43	FJX1	four jointed box 1 (Drosophila)	3098	0.31
chr3_153778293_153778444	0.43	ENSG00000243069	.	20913	0.21
chr6_134557030_134557181	0.43	ENSG00000200058	.	21068	0.16
chr8_90739151_90739302	0.43	RIPK2	receptor-interacting serine-threonine kinase 2	30749	0.24
chr6_53928552_53928746	0.43	MLIP-AS1	MLIP antisense RNA 1	15875	0.2
chr9_16726683_16727481	0.42	RP11-62F24.2		270	0.85
chr14_31887812_31887963	0.42	CTD-2213F21.2		1605	0.27
chr12_118628413_118628612	0.42	TAOK3	TAO kinase 3	156	0.96
chr15_38547811_38548278	0.41	SPRED1	sprouty-related, EVH1 domain containing 1	2662	0.42
chr14_60561615_60561766	0.41	PCNXL4	pecanex-like 4 (Drosophila)	3045	0.25
chr3_105657205_105657471	0.41	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	68942	0.15
chr7_93551338_93552000	0.41	GNG11	guanine nucleotide binding protein (G protein), gamma 11	658	0.67
chr21_40365344_40365495	0.41	ENSG00000272015	.	98710	0.08
chr3_98616068_98616219	0.41	DCBLD2	discoidin, CUB and LCCL domain containing 2	3872	0.21
chr8_142141679_142142152	0.41	RP11-809O17.1		1855	0.33
chr16_28193130_28193587	0.41	XPO6	exportin 6	915	0.43
chr9_111058733_111058884	0.41	ENSG00000222512	.	62401	0.16
chr12_50927086_50927306	0.40	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	28306	0.19
chr6_27182410_27182602	0.40	PRSS16	protease, serine, 16 (thymus)	32974	0.13
chr5_107229567_107229740	0.40	ENSG00000251732	.	83323	0.11
chr1_46420407_46420664	0.40	MAST2	microtubule associated serine/threonine kinase 2	41275	0.16
chr20_48319819_48319972	0.40	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	10520	0.19
chr15_42749459_42749764	0.39	ZNF106	zinc finger protein 106	100	0.96
chr18_67714970_67715121	0.39	RTTN	rotatin	27091	0.24
chr1_173807426_173807577	0.39	DARS2	aspartyl-tRNA synthetase 2, mitochondrial	13704	0.1
chr4_122686341_122686757	0.39	TMEM155	transmembrane protein 155	33	0.94
chr12_80081310_80081535	0.39	PAWR	PRKC, apoptosis, WT1, regulator	2438	0.38
chr15_49715834_49715985	0.39	FGF7	fibroblast growth factor 7	452	0.86
chr17_79533812_79534253	0.39	NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	371	0.75
chr11_22724799_22724998	0.38	ENSG00000222427	.	15001	0.2
chr2_151896468_151896724	0.38	AC023469.1	HCG1817310; Uncharacterized protein	8692	0.28
chr14_101867418_101867569	0.38	ENSG00000258498	.	159266	0.02
chr2_217461840_217461991	0.38	AC073321.3		9746	0.19
chr14_65928823_65928974	0.38	ENSG00000207781	.	8922	0.25
chr15_41316852_41317003	0.38	RP11-540O11.4		230	0.91
chr5_15021667_15021945	0.38	ENSG00000202269	.	89223	0.09
chr8_110987229_110987457	0.38	KCNV1	potassium channel, subfamily V, member 1	384	0.81
chr7_90012947_90013805	0.38	CLDN12	claudin 12	341	0.9
chr6_56595678_56595829	0.38	DST	dystonin	54924	0.16
chr1_234700242_234700393	0.37	ENSG00000212144	.	28704	0.16
chr18_60434411_60434742	0.37	ENSG00000206746	.	36011	0.15
chr10_101768167_101768400	0.37	DNMBP	dynamin binding protein	1393	0.42
chr2_113538908_113539059	0.37	IL1A	interleukin 1, alpha	3184	0.22
chr20_35923242_35923439	0.37	MANBAL	mannosidase, beta A, lysosomal-like	1959	0.35
chr6_6005898_6006049	0.37	NRN1	neuritin 1	1227	0.56
chr10_21800964_21801188	0.37	SKIDA1	SKI/DACH domain containing 1	5772	0.14
chr1_95005421_95005705	0.37	F3	coagulation factor III (thromboplastin, tissue factor)	1630	0.52
chr6_86167890_86168219	0.37	NT5E	5'-nucleotidase, ecto (CD73)	8227	0.28
chr4_44681433_44681584	0.37	YIPF7	Yip1 domain family, member 7	935	0.39
chr6_123316934_123317301	0.36	CLVS2	clavesin 2	1	0.99
chr18_61445658_61445809	0.36	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	522	0.82
chr1_164529707_164529858	0.36	PBX1	pre-B-cell leukemia homeobox 1	722	0.78
chr10_17273946_17274204	0.36	VIM	vimentin	1467	0.3
chr17_5420049_5420318	0.36	ENSG00000253071	.	2593	0.22
chr12_52347769_52348164	0.36	ACVR1B	activin A receptor, type IB	802	0.57
chr2_9699691_9699891	0.36	ADAM17	ADAM metallopeptidase domain 17	3870	0.21
chr15_88020923_88021173	0.36	ENSG00000207150	.	3528	0.4
chr17_49125210_49125361	0.36	SPAG9	sperm associated antigen 9	1046	0.5
chr8_121681395_121681546	0.36	RP11-713M15.1		92023	0.09
chr8_119427050_119427214	0.36	AC023590.1	Uncharacterized protein	132651	0.05
chr2_242257443_242257594	0.36	HDLBP	high density lipoprotein binding protein	1042	0.41
chr6_148736290_148736441	0.36	SASH1	SAM and SH3 domain containing 1	72636	0.12
chr14_62176388_62176539	0.35	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	12123	0.24
chr4_74087462_74087866	0.35	ANKRD17	ankyrin repeat domain 17	1167	0.53
chr18_60385543_60385694	0.35	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	2935	0.28
chr8_25868117_25868310	0.35	EBF2	early B-cell factor 2	30791	0.24
chr7_97361017_97361340	0.35	TAC1	tachykinin, precursor 1	42	0.99
chr4_26344236_26344574	0.35	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	357	0.93
chr1_120255525_120255935	0.35	PHGDH	phosphoglycerate dehydrogenase	1220	0.51
chr7_92224542_92224693	0.35	FAM133B	family with sequence similarity 133, member B	4909	0.24
chr1_62071878_62072329	0.35	ENSG00000264551	.	22600	0.25
chr7_24988449_24988600	0.35	OSBPL3	oxysterol binding protein-like 3	30812	0.21
chr2_55239893_55240193	0.35	ENSG00000200086	.	1614	0.37
chr9_109625885_109626257	0.34	ZNF462	zinc finger protein 462	624	0.77
chr2_158039761_158039912	0.34	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	74274	0.11
chr10_86184623_86185188	0.34	CCSER2	coiled-coil serine-rich protein 2	210	0.97
chr21_39807445_39807798	0.34	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	62724	0.14
chr3_174675589_174675952	0.34	NAALADL2	N-acetylated alpha-linked acidic dipeptidase-like 2	98700	0.09
chr17_42214986_42215221	0.33	ENSG00000212446	.	1746	0.18
chr7_70201396_70202343	0.33	AUTS2	autism susceptibility candidate 2	7744	0.34
chr16_55401499_55401650	0.33	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	22038	0.18
chr4_148947037_148947237	0.33	RP11-76G10.1		120485	0.06
chr5_142562344_142562495	0.33	ARHGAP26-IT1	ARHGAP26 intronic transcript 1 (non-protein coding)	9646	0.25
chr11_131780111_131780399	0.33	NTM	neurotrimin	642	0.77
chr5_16593515_16593666	0.33	RP11-260E18.1		22445	0.17
chr1_45083000_45083241	0.33	RNF220	ring finger protein 220	8878	0.17
chr3_54897831_54897982	0.33	CACNA2D3-AS1	CACNA2D3 antisense RNA 1	37376	0.21
chr3_11556089_11556255	0.33	VGLL4	vestigial like 4 (Drosophila)	54226	0.15
chr12_49581087_49581445	0.33	TUBA1A	tubulin, alpha 1a	25	0.96
chr2_109210392_109210708	0.33	LIMS1	LIM and senescent cell antigen-like domains 1	5628	0.26
chr2_176992012_176992333	0.32	HOXD8	homeobox D8	2250	0.12
chr7_39872474_39872794	0.32	ENSG00000242855	.	55338	0.13
chr12_109122720_109122871	0.32	CORO1C	coronin, actin binding protein, 1C	1532	0.34
chr12_10548505_10548720	0.32	KLRK1	killer cell lectin-like receptor subfamily K, member 1	5995	0.13
chr3_88191159_88191414	0.32	ZNF654	zinc finger protein 654	3032	0.24
chr12_41224022_41224173	0.32	CNTN1	contactin 1	2111	0.48
chr8_87317262_87317629	0.32	WWP1	WW domain containing E3 ubiquitin protein ligase 1	37522	0.18
chr5_19885020_19885171	0.31	CDH18	cadherin 18, type 2	1286	0.64
chr1_102791433_102791584	0.31	OLFM3	olfactomedin 3	328922	0.01
chr2_159456331_159456527	0.31	ENSG00000251721	.	65717	0.12
chr2_239695781_239695932	0.31	TWIST2	twist family bHLH transcription factor 2	60817	0.13
chr18_28779723_28779874	0.31	DSC1	desmocollin 1	36979	0.15
chr5_38807697_38807893	0.31	RP11-122C5.3		24113	0.22
chr4_48779368_48779519	0.31	FRYL	FRY-like	2822	0.3
chr8_126231853_126232267	0.31	ENSG00000242170	.	50786	0.15
chr18_9742659_9743173	0.31	RAB31	RAB31, member RAS oncogene family	34754	0.17
chr13_86159310_86159559	0.31	ENSG00000207012	.	446	0.91
chr4_177824622_177824937	0.31	VEGFC	vascular endothelial growth factor C	110898	0.07
chr2_161224712_161224959	0.31	ENSG00000252465	.	28644	0.18
chr4_42361739_42361897	0.31	RP11-63A11.1		31432	0.19
chr9_75568093_75568244	0.31	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	196	0.97
chr2_55810269_55810420	0.31	ENSG00000212175	.	17505	0.15
chr14_71838887_71839322	0.30	ENSG00000207444	.	25950	0.19
chr2_207998546_207999225	0.30	KLF7	Kruppel-like factor 7 (ubiquitous)	24	0.98
chr10_78157088_78157239	0.30	RP11-369F10.2		41370	0.18
chr4_178222633_178222784	0.30	NEIL3	nei endonuclease VIII-like 3 (E. coli)	8282	0.23
chr16_88472278_88472669	0.30	ZNF469	zinc finger protein 469	21406	0.18
chr8_99334814_99335068	0.30	NIPAL2	NIPA-like domain containing 2	28320	0.2
chr17_67137246_67137397	0.30	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	694	0.69
chr15_63050120_63050513	0.30	TLN2	talin 2	473	0.82
chr10_5491792_5492244	0.30	NET1	neuroepithelial cell transforming 1	3444	0.22
chr13_23946605_23946801	0.30	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	2979	0.39
chr1_100317573_100317724	0.30	AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	578	0.74
chr11_111848673_111848997	0.30	DIXDC1	DIX domain containing 1	802	0.5
chr13_106938318_106938469	0.30	ENSG00000222682	.	130554	0.06
chr3_114477857_114478359	0.30	ZBTB20	zinc finger and BTB domain containing 20	10	0.99
chr14_96723158_96723326	0.30	BDKRB1	bradykinin receptor B1	695	0.57
chr5_62570567_62570718	0.30	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	687138	0.0
chr16_51671642_51672070	0.29	ENSG00000223168	.	33618	0.25
chr5_102000842_102000993	0.29	PAM	peptidylglycine alpha-amidating monooxygenase	88768	0.1
chr13_73631347_73631498	0.29	KLF5	Kruppel-like factor 5 (intestinal)	1508	0.47
chr14_52339728_52339879	0.29	GNG2	guanine nucleotide binding protein (G protein), gamma 2	4507	0.23
chr8_29027576_29027748	0.29	ENSG00000264328	.	27452	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.2	0.6	GO:0030210	heparin biosynthetic process(GO:0030210)
0.2	0.8	GO:0060437	lung growth(GO:0060437)
0.2	0.5	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.4	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.4	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.4	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	0.3	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1	0.2	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1	0.5	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.1	0.2	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1	0.2	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.6	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.2	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.1	0.1	GO:0002246	wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.1	0.3	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	0.1	GO:0072033	renal vesicle formation(GO:0072033)
0.1	0.3	GO:0010664	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.1	0.4	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1	0.6	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.1	0.2	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.1	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.1	0.1	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.2	GO:0002024	diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.3	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.6	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.2	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.2	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.4	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.2	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.3	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.2	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.4	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.2	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.0	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.2	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0060526	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.5	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.3	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.2	GO:0051567	histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.1	GO:0006623	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.1	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0072081	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.2	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.2	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0	0.2	GO:0014037	Schwann cell differentiation(GO:0014037)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.4	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.0	GO:0043587	tongue morphogenesis(GO:0043587)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.3	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.0	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.0	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.0	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0016925	protein sumoylation(GO:0016925)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.0	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.3	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.0	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.0	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.0	GO:0043438	acetoacetic acid metabolic process(GO:0043438)
0.0	0.1	GO:0051552	flavone metabolic process(GO:0051552)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.0	GO:0090224	regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0	0.0	GO:0046541	saliva secretion(GO:0046541)
0.0	0.3	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.3	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.3	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.2	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.2	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.6	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	1.3	GO:0030027	lamellipodium(GO:0030027)
0.0	0.1	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.6	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.4	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.5	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.6	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.3	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.2	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1	0.5	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	0.2	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.3	GO:0016361	activin receptor activity, type I(GO:0016361)
0.1	0.3	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.3	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	0.3	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.2	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.4	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.2	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.5	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.4	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.5	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.2	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.6	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.4	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.4	GO:0008200	ion channel inhibitor activity(GO:0008200)
0.0	0.3	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.3	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.5	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.3	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.0	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.2	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.0	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.0	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.7	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.1	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.0	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID S1P S1P1 PATHWAY	S1P1 pathway
0.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.9	PID SHP2 PATHWAY	SHP2 signaling
0.6	PID FGF PATHWAY	FGF signaling pathway
0.9	PID NOTCH PATHWAY	Notch signaling pathway
0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.4	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.5	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.6	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.4	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
1.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.4	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.5	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.3	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.4	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.1	REACTOME SIGNALING BY WNT	Genes involved in Signaling by Wnt
0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane