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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for LHX3

Z-value: 1.23

Motif logo

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.11 LIM homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr9_139091429_139091580LHX335000.2294680.156.9e-01Click!
chr9_139090516_139090790LHX343510.212434-0.001.0e+00Click!

Activity of the LHX3 motif across conditions

Conditions sorted by the z-value of the LHX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_41215270_41215769 1.01 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 956
 0.59
chr8_116675050_116675578 0.98 TRPS1
 trichorhinophalangeal syndrome I
 1409
 0.6
chr9_89952337_89952906 0.96 ENSG00000212421
 .
 77256
 0.11
chr12_66286178_66286489 0.75 RP11-366L20.2
 Uncharacterized protein
 10386
 0.18
chr11_122311553_122311819 0.74 ENSG00000252776
 .
 8232
 0.23
chr17_35851874_35852313 0.73 DUSP14
 dual specificity phosphatase 14
 523
 0.79
chr3_79066759_79066910 0.72 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
 860
 0.75
chr6_27060216_27060434 0.71 ENSG00000222800
 .
 17434
 0.13
chrX_114829080_114829277 0.70 PLS3
 plastin 3
 1313
 0.48
chr7_98970111_98970529 0.70 ARPC1B
 actin related protein 2/3 complex, subunit 1B, 41kDa
 1552
 0.28
chr18_42313149_42313495 0.70 SETBP1
 SET binding protein 1
 36193
 0.24
chr6_147234783_147235185 0.69 STXBP5-AS1
 STXBP5 antisense RNA 1
 2037
 0.48
chr3_33318777_33319866 0.67 FBXL2
 F-box and leucine-rich repeat protein 2
 353
 0.91
chr20_46412966_46413363 0.66 SULF2
 sulfatase 2
 1069
 0.59
chr4_108746841_108747185 0.65 SGMS2
 sphingomyelin synthase 2
 649
 0.76
chr4_140808579_140808865 0.64 MAML3
 mastermind-like 3 (Drosophila)
 2484
 0.4
chr10_33798417_33798757 0.64 NRP1
 neuropilin 1
 173397
 0.03
chr9_97812256_97812766 0.64 ENSG00000207563
 .
 34979
 0.12
chr13_80912572_80913077 0.62 SPRY2
 sprouty homolog 2 (Drosophila)
 970
 0.67
chr3_60921693_60921844 0.62 ENSG00000212211
 .
 79491
 0.12
chr12_104443157_104443419 0.60 GLT8D2
 glycosyltransferase 8 domain containing 2
 626
 0.69
chr3_120168709_120169860 0.60 FSTL1
 follistatin-like 1
 554
 0.84
chrX_139792263_139792666 0.60 LINC00632
 long intergenic non-protein coding RNA 632
 532
 0.82
chr19_52452059_52452669 0.59 HCCAT3
 hepatocellular carcinoma associated transcript 3 (non-protein coding)
 23
 0.96
chr1_120191467_120191618 0.57 ZNF697
 zinc finger protein 697
 1146
 0.52
chr12_109116833_109117152 0.55 CORO1C
 coronin, actin binding protein, 1C
 7335
 0.16
chr5_120114861_120115414 0.55 ENSG00000222609
 .
 68602
 0.14
chr8_108506884_108507225 0.54 ANGPT1
 angiopoietin 1
 169
 0.98
chr3_12235413_12235694 0.54 TIMP4
 TIMP metallopeptidase inhibitor 4
 34702
 0.2
chrX_39548256_39548819 0.54 ENSG00000263730
 .
 28067
 0.24
chr5_124748322_124748473 0.54 ENSG00000222107
 .
 61573
 0.16
chr13_24146066_24146217 0.54 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 1338
 0.59
chr4_25238162_25238313 0.53 PI4K2B
 phosphatidylinositol 4-kinase type 2 beta
 2640
 0.35
chr11_111849006_111849202 0.53 DIXDC1
 DIX domain containing 1
 1071
 0.39
chr8_107738861_107739281 0.53 OXR1
 oxidation resistance 1
 658
 0.71
chr5_1883178_1883404 0.53 IRX4
 iroquois homeobox 4
 411
 0.66
chr18_53089837_53090372 0.53 TCF4
 transcription factor 4
 361
 0.89
chr1_245361051_245361416 0.53 RP11-62I21.1
36570
 0.15
chr13_79182716_79183828 0.52 POU4F1
 POU class 4 homeobox 1
 5599
 0.19
chr3_100785098_100785499 0.52 ABI3BP
 ABI family, member 3 (NESH) binding protein
 72939
 0.11
chr11_89113858_89114276 0.51 NOX4
 NADPH oxidase 4
 109833
 0.07
chr6_28442401_28443147 0.51 ZSCAN23
 zinc finger and SCAN domain containing 23
 31530
 0.13
chr14_52821573_52821780 0.51 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 40563
 0.18
chr7_28726429_28726958 0.51 CREB5
 cAMP responsive element binding protein 5
 1095
 0.68
chr1_64197696_64197847 0.51 ROR1
 receptor tyrosine kinase-like orphan receptor 1
 41922
 0.17
chr14_75039149_75039311 0.51 LTBP2
 latent transforming growth factor beta binding protein 2
 39545
 0.13
chr22_18575359_18575510 0.51 XXbac-B476C20.9
13784
 0.14
chr4_54424539_54424751 0.51 LNX1
 ligand of numb-protein X 1, E3 ubiquitin protein ligase
 261
 0.93
chr13_45242490_45242715 0.49 ENSG00000238932
 .
 39793
 0.2
chr10_33621519_33621932 0.49 NRP1
 neuropilin 1
 1585
 0.49
chr9_93557702_93558119 0.49 SYK
 spleen tyrosine kinase
 6159
 0.34
chr15_99444137_99444307 0.49 RP11-654A16.1
7458
 0.22
chr2_164590425_164590732 0.49 FIGN
 fidgetin
 1939
 0.52
chr5_72327202_72327380 0.48 ENSG00000200833
 .
 68609
 0.09
chr7_110879115_110879283 0.48 ENSG00000238922
 .
 129786
 0.05
chr16_53244996_53245358 0.48 CHD9
 chromodomain helicase DNA binding protein 9
 2814
 0.29
chr14_75038296_75038530 0.48 LTBP2
 latent transforming growth factor beta binding protein 2
 40362
 0.13
chr15_45940670_45940821 0.48 SQRDL
 sulfide quinone reductase-like (yeast)
 2666
 0.28
chr1_182365770_182365966 0.48 TEDDM1
 transmembrane epididymal protein 1
 3883
 0.23
chr2_38295840_38295991 0.47 RMDN2-AS1
 RMDN2 antisense RNA 1
 1731
 0.34
chr7_17720120_17720505 0.47 SNX13
 sorting nexin 13
 259779
 0.02
chr5_57134719_57134870 0.47 ENSG00000266864
 .
 34079
 0.24
chr5_173000019_173000195 0.47 CTB-33O18.3
6539
 0.26
chr10_62335914_62336175 0.44 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 3623
 0.38
chr5_54456050_54456451 0.44 GPX8
 glutathione peroxidase 8 (putative)
 252
 0.86
chr13_97930897_97931108 0.44 MBNL2
 muscleblind-like splicing regulator 2
 2544
 0.4
chr16_53809887_53810055 0.43 FTO
 fat mass and obesity associated
 71877
 0.11
chr11_35642709_35642958 0.43 FJX1
 four jointed box 1 (Drosophila)
 3098
 0.31
chr3_153778293_153778444 0.43 ENSG00000243069
 .
 20913
 0.21
chr6_134557030_134557181 0.43 ENSG00000200058
 .
 21068
 0.16
chr8_90739151_90739302 0.43 RIPK2
 receptor-interacting serine-threonine kinase 2
 30749
 0.24
chr6_53928552_53928746 0.43 MLIP-AS1
 MLIP antisense RNA 1
 15875
 0.2
chr9_16726683_16727481 0.42 RP11-62F24.2
270
 0.85
chr14_31887812_31887963 0.42 CTD-2213F21.2
1605
 0.27
chr12_118628413_118628612 0.42 TAOK3
 TAO kinase 3
 156
 0.96
chr15_38547811_38548278 0.41 SPRED1
 sprouty-related, EVH1 domain containing 1
 2662
 0.42
chr14_60561615_60561766 0.41 PCNXL4
 pecanex-like 4 (Drosophila)
 3045
 0.25
chr3_105657205_105657471 0.41 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 68942
 0.15
chr7_93551338_93552000 0.41 GNG11
 guanine nucleotide binding protein (G protein), gamma 11
 658
 0.67
chr21_40365344_40365495 0.41 ENSG00000272015
 .
 98710
 0.08
chr3_98616068_98616219 0.41 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 3872
 0.21
chr8_142141679_142142152 0.41 RP11-809O17.1
1855
 0.33
chr16_28193130_28193587 0.41 XPO6
 exportin 6
 915
 0.43
chr9_111058733_111058884 0.41 ENSG00000222512
 .
 62401
 0.16
chr12_50927086_50927306 0.40 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 28306
 0.19
chr6_27182410_27182602 0.40 PRSS16
 protease, serine, 16 (thymus)
 32974
 0.13
chr5_107229567_107229740 0.40 ENSG00000251732
 .
 83323
 0.11
chr1_46420407_46420664 0.40 MAST2
 microtubule associated serine/threonine kinase 2
 41275
 0.16
chr20_48319819_48319972 0.40 B4GALT5
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
 10520
 0.19
chr15_42749459_42749764 0.39 ZNF106
 zinc finger protein 106
 100
 0.96
chr18_67714970_67715121 0.39 RTTN
 rotatin
 27091
 0.24
chr1_173807426_173807577 0.39 DARS2
 aspartyl-tRNA synthetase 2, mitochondrial
 13704
 0.1
chr4_122686341_122686757 0.39 TMEM155
 transmembrane protein 155
 33
 0.94
chr12_80081310_80081535 0.39 PAWR
 PRKC, apoptosis, WT1, regulator
 2438
 0.38
chr15_49715834_49715985 0.39 FGF7
 fibroblast growth factor 7
 452
 0.86
chr17_79533812_79534253 0.39 NPLOC4
 nuclear protein localization 4 homolog (S. cerevisiae)
 371
 0.75
chr11_22724799_22724998 0.38 ENSG00000222427
 .
 15001
 0.2
chr2_151896468_151896724 0.38 AC023469.1
 HCG1817310; Uncharacterized protein
 8692
 0.28
chr14_101867418_101867569 0.38 ENSG00000258498
 .
 159266
 0.02
chr2_217461840_217461991 0.38 AC073321.3
9746
 0.19
chr14_65928823_65928974 0.38 ENSG00000207781
 .
 8922
 0.25
chr15_41316852_41317003 0.38 RP11-540O11.4
230
 0.91
chr5_15021667_15021945 0.38 ENSG00000202269
 .
 89223
 0.09
chr8_110987229_110987457 0.38 KCNV1
 potassium channel, subfamily V, member 1
 384
 0.81
chr7_90012947_90013805 0.38 CLDN12
 claudin 12
 341
 0.9
chr6_56595678_56595829 0.38 DST
 dystonin
 54924
 0.16
chr1_234700242_234700393 0.37 ENSG00000212144
 .
 28704
 0.16
chr18_60434411_60434742 0.37 ENSG00000206746
 .
 36011
 0.15
chr10_101768167_101768400 0.37 DNMBP
 dynamin binding protein
 1393
 0.42
chr2_113538908_113539059 0.37 IL1A
 interleukin 1, alpha
 3184
 0.22
chr20_35923242_35923439 0.37 MANBAL
 mannosidase, beta A, lysosomal-like
 1959
 0.35
chr6_6005898_6006049 0.37 NRN1
 neuritin 1
 1227
 0.56
chr10_21800964_21801188 0.37 SKIDA1
 SKI/DACH domain containing 1
 5772
 0.14
chr1_95005421_95005705 0.37 F3
 coagulation factor III (thromboplastin, tissue factor)
 1630
 0.52
chr6_86167890_86168219 0.37 NT5E
 5'-nucleotidase, ecto (CD73)
 8227
 0.28
chr4_44681433_44681584 0.37 YIPF7
 Yip1 domain family, member 7
 935
 0.39
chr6_123316934_123317301 0.36 CLVS2
 clavesin 2
 1
 0.99
chr18_61445658_61445809 0.36 SERPINB7
 serpin peptidase inhibitor, clade B (ovalbumin), member 7
 522
 0.82
chr1_164529707_164529858 0.36 PBX1
 pre-B-cell leukemia homeobox 1
 722
 0.78
chr10_17273946_17274204 0.36 VIM
 vimentin
 1467
 0.3
chr17_5420049_5420318 0.36 ENSG00000253071
 .
 2593
 0.22
chr12_52347769_52348164 0.36 ACVR1B
 activin A receptor, type IB
 802
 0.57
chr2_9699691_9699891 0.36 ADAM17
 ADAM metallopeptidase domain 17
 3870
 0.21
chr15_88020923_88021173 0.36 ENSG00000207150
 .
 3528
 0.4
chr17_49125210_49125361 0.36 SPAG9
 sperm associated antigen 9
 1046
 0.5
chr8_121681395_121681546 0.36 RP11-713M15.1
92023
 0.09
chr8_119427050_119427214 0.36 AC023590.1
 Uncharacterized protein
 132651
 0.05
chr2_242257443_242257594 0.36 HDLBP
 high density lipoprotein binding protein
 1042
 0.41
chr6_148736290_148736441 0.36 SASH1
 SAM and SH3 domain containing 1
 72636
 0.12
chr14_62176388_62176539 0.35 HIF1A
 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
 12123
 0.24
chr4_74087462_74087866 0.35 ANKRD17
 ankyrin repeat domain 17
 1167
 0.53
chr18_60385543_60385694 0.35 PHLPP1
 PH domain and leucine rich repeat protein phosphatase 1
 2935
 0.28
chr8_25868117_25868310 0.35 EBF2
 early B-cell factor 2
 30791
 0.24
chr7_97361017_97361340 0.35 TAC1
 tachykinin, precursor 1
 42
 0.99
chr4_26344236_26344574 0.35 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 357
 0.93
chr1_120255525_120255935 0.35 PHGDH
 phosphoglycerate dehydrogenase
 1220
 0.51
chr7_92224542_92224693 0.35 FAM133B
 family with sequence similarity 133, member B
 4909
 0.24
chr1_62071878_62072329 0.35 ENSG00000264551
 .
 22600
 0.25
chr7_24988449_24988600 0.35 OSBPL3
 oxysterol binding protein-like 3
 30812
 0.21
chr2_55239893_55240193 0.35 ENSG00000200086
 .
 1614
 0.37
chr9_109625885_109626257 0.34 ZNF462
 zinc finger protein 462
 624
 0.77
chr2_158039761_158039912 0.34 GALNT5
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
 74274
 0.11
chr10_86184623_86185188 0.34 CCSER2
 coiled-coil serine-rich protein 2
 210
 0.97
chr21_39807445_39807798 0.34 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 62724
 0.14
chr3_174675589_174675952 0.34 NAALADL2
 N-acetylated alpha-linked acidic dipeptidase-like 2
 98700
 0.09
chr17_42214986_42215221 0.33 ENSG00000212446
 .
 1746
 0.18
chr7_70201396_70202343 0.33 AUTS2
 autism susceptibility candidate 2
 7744
 0.34
chr16_55401499_55401650 0.33 MMP2
 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
 22038
 0.18
chr4_148947037_148947237 0.33 RP11-76G10.1
120485
 0.06
chr5_142562344_142562495 0.33 ARHGAP26-IT1
 ARHGAP26 intronic transcript 1 (non-protein coding)
 9646
 0.25
chr11_131780111_131780399 0.33 NTM
 neurotrimin
 642
 0.77
chr5_16593515_16593666 0.33 RP11-260E18.1
22445
 0.17
chr1_45083000_45083241 0.33 RNF220
 ring finger protein 220
 8878
 0.17
chr3_54897831_54897982 0.33 CACNA2D3-AS1
 CACNA2D3 antisense RNA 1
 37376
 0.21
chr3_11556089_11556255 0.33 VGLL4
 vestigial like 4 (Drosophila)
 54226
 0.15
chr12_49581087_49581445 0.33 TUBA1A
 tubulin, alpha 1a
 25
 0.96
chr2_109210392_109210708 0.33 LIMS1
 LIM and senescent cell antigen-like domains 1
 5628
 0.26
chr2_176992012_176992333 0.32 HOXD8
 homeobox D8
 2250
 0.12
chr7_39872474_39872794 0.32 ENSG00000242855
 .
 55338
 0.13
chr12_109122720_109122871 0.32 CORO1C
 coronin, actin binding protein, 1C
 1532
 0.34
chr12_10548505_10548720 0.32 KLRK1
 killer cell lectin-like receptor subfamily K, member 1
 5995
 0.13
chr3_88191159_88191414 0.32 ZNF654
 zinc finger protein 654
 3032
 0.24
chr12_41224022_41224173 0.32 CNTN1
 contactin 1
 2111
 0.48
chr8_87317262_87317629 0.32 WWP1
 WW domain containing E3 ubiquitin protein ligase 1
 37522
 0.18
chr5_19885020_19885171 0.31 CDH18
 cadherin 18, type 2
 1286
 0.64
chr1_102791433_102791584 0.31 OLFM3
 olfactomedin 3
 328922
 0.01
chr2_159456331_159456527 0.31 ENSG00000251721
 .
 65717
 0.12
chr2_239695781_239695932 0.31 TWIST2
 twist family bHLH transcription factor 2
 60817
 0.13
chr18_28779723_28779874 0.31 DSC1
 desmocollin 1
 36979
 0.15
chr5_38807697_38807893 0.31 RP11-122C5.3
24113
 0.22
chr4_48779368_48779519 0.31 FRYL
 FRY-like
 2822
 0.3
chr8_126231853_126232267 0.31 ENSG00000242170
 .
 50786
 0.15
chr18_9742659_9743173 0.31 RAB31
 RAB31, member RAS oncogene family
 34754
 0.17
chr13_86159310_86159559 0.31 ENSG00000207012
 .
 446
 0.91
chr4_177824622_177824937 0.31 VEGFC
 vascular endothelial growth factor C
 110898
 0.07
chr2_161224712_161224959 0.31 ENSG00000252465
 .
 28644
 0.18
chr4_42361739_42361897 0.31 RP11-63A11.1
31432
 0.19
chr9_75568093_75568244 0.31 ALDH1A1
 aldehyde dehydrogenase 1 family, member A1
 196
 0.97
chr2_55810269_55810420 0.31 ENSG00000212175
 .
 17505
 0.15
chr14_71838887_71839322 0.30 ENSG00000207444
 .
 25950
 0.19
chr2_207998546_207999225 0.30 KLF7
 Kruppel-like factor 7 (ubiquitous)
 24
 0.98
chr10_78157088_78157239 0.30 RP11-369F10.2
41370
 0.18
chr4_178222633_178222784 0.30 NEIL3
 nei endonuclease VIII-like 3 (E. coli)
 8282
 0.23
chr16_88472278_88472669 0.30 ZNF469
 zinc finger protein 469
 21406
 0.18
chr8_99334814_99335068 0.30 NIPAL2
 NIPA-like domain containing 2
 28320
 0.2
chr17_67137246_67137397 0.30 ABCA6
 ATP-binding cassette, sub-family A (ABC1), member 6
 694
 0.69
chr15_63050120_63050513 0.30 TLN2
 talin 2
 473
 0.82
chr10_5491792_5492244 0.30 NET1
 neuroepithelial cell transforming 1
 3444
 0.22
chr13_23946605_23946801 0.30 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
 2979
 0.39
chr1_100317573_100317724 0.30 AGL
 amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
 578
 0.74
chr11_111848673_111848997 0.30 DIXDC1
 DIX domain containing 1
 802
 0.5
chr13_106938318_106938469 0.30 ENSG00000222682
 .
 130554
 0.06
chr3_114477857_114478359 0.30 ZBTB20
 zinc finger and BTB domain containing 20
 10
 0.99
chr14_96723158_96723326 0.30 BDKRB1
 bradykinin receptor B1
 695
 0.57
chr5_62570567_62570718 0.30 HTR1A
 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
 687138
 0.0
chr16_51671642_51672070 0.29 ENSG00000223168
 .
 33618
 0.25
chr5_102000842_102000993 0.29 PAM
 peptidylglycine alpha-amidating monooxygenase
 88768
 0.1
chr13_73631347_73631498 0.29 KLF5
 Kruppel-like factor 5 (intestinal)
 1508
 0.47
chr14_52339728_52339879 0.29 GNG2
 guanine nucleotide binding protein (G protein), gamma 2
 4507
 0.23
chr8_29027576_29027748 0.29 ENSG00000264328
 .
 27452
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.2 0.6 GO:0030210 heparin biosynthetic process(GO:0030210)
0.2 0.8 GO:0060437 lung growth(GO:0060437)
0.2 0.5 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.3 GO:0031394 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 0.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.2 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 0.2 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.1 0.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.2 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 0.1 GO:0002246 wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.1 0.2 GO:0010193 response to ozone(GO:0010193)
0.1 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.1 GO:0072033 renal vesicle formation(GO:0072033)
0.1 0.3 GO:0010664 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1 0.6 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.1 0.2 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1 0.1 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.1 0.1 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.2 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.2 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.4 GO:0006069 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:1903170 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.0 GO:0048541 Peyer's patch development(GO:0048541)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.0 0.0 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.2 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0060526 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0051567 histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.1 GO:0006623 protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0 0.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.2 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.4 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0043537 negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0 0.0 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.3 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.0 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.0 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.0 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.3 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.1 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.0 0.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.1 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.0 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.1 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0 0.0 GO:0046541 saliva secretion(GO:0046541)
0.0 0.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.6 GO:0005902 microvillus(GO:0005902)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 1.3 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.6 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.5 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.2 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.2 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.4 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.0 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.0 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.0 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.0 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.0 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.0 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.9 PID SHP2 PATHWAY SHP2 signaling
0.0 0.6 PID FGF PATHWAY FGF signaling pathway
0.0 0.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.0 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.1 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.1 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.0 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.2 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane