Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for LHX8

Z-value: 1.13

Motif logo

Transcription factors associated with LHX8

Gene Symbol	Gene ID	Gene Info
LHX8 Ensembl NCBI GeneCards UniProt	ENSG00000162624.10	LHX8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
LHX8	chr1_75571987_75572138	22057	0.172584	0.22	5.8e-01	Click!
LHX8	chr1_75600688_75601584	569	0.698057	-0.21	5.9e-01	Click!

Activity of the LHX8 motif across conditions

Conditions sorted by the z-value of the LHX8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_28373361_28373512	0.60	LINGO2	leucine rich repeat and Ig domain containing 2	296847	0.01
chr7_76785964_76786115	0.49	CCDC146	coiled-coil domain containing 146	34105	0.15
chr18_72647452_72647603	0.36	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	269941	0.02
chr1_227501047_227501198	0.34	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	3761	0.35
chr8_66868091_66868242	0.32	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	65629	0.13
chr2_233565064_233565215	0.31	GIGYF2	GRB10 interacting GYF protein 2	3077	0.19
chr4_39570973_39571124	0.29	UGDH	UDP-glucose 6-dehydrogenase	41117	0.11
chr10_4023404_4023555	0.29	KLF6	Kruppel-like factor 6	196006	0.03
chr1_66806017_66806168	0.29	PDE4B	phosphodiesterase 4B, cAMP-specific	8220	0.31
chr22_17598033_17598230	0.27	CECR6	cat eye syndrome chromosome region, candidate 6	4012	0.17
chr22_41249705_41249922	0.26	ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	789	0.51
chrX_68835519_68835670	0.26	EDA	ectodysplasin A	317	0.92
chr18_30563491_30563642	0.26	RP11-680N20.1		29527	0.24
chr10_27312512_27312663	0.25	ANKRD26	ankyrin repeat domain 26	8979	0.23
chr11_122502980_122503131	0.25	UBASH3B	ubiquitin associated and SH3 domain containing B	23328	0.21
chr2_55986068_55986219	0.25	PNPT1	polyribonucleotide nucleotidyltransferase 1	65098	0.11
chr9_3827440_3827591	0.25	RP11-252M18.3		48069	0.17
chr2_231429944_231430095	0.25	AC010149.4		14629	0.18
chr6_10522784_10522935	0.25	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	1275	0.45
chr8_90031831_90031982	0.24	RP11-586K2.1		319386	0.01
chr7_38400564_38400715	0.24	AMPH	amphiphysin	102074	0.08
chr10_89692060_89692211	0.24	RP11-380G5.2		53686	0.11
chr7_116341288_116341439	0.24	MET	met proto-oncogene	2224	0.39
chr5_158301830_158301981	0.23	CTD-2363C16.1		108109	0.07
chr18_12596428_12596579	0.23	SPIRE1	spire-type actin nucleation factor 1	56581	0.09
chr14_105759141_105759292	0.23	BRF1	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	7589	0.16
chr20_52726952_52727103	0.23	BCAS1	breast carcinoma amplified sequence 1	39723	0.15
chr13_78109984_78110135	0.23	SCEL	sciellin	164	0.97
chr2_242063252_242063403	0.23	PASK	PAS domain containing serine/threonine kinase	15683	0.13
chr14_52867726_52867877	0.23	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	86688	0.09
chr2_200778375_200778671	0.23	C2orf69	chromosome 2 open reading frame 69	2544	0.27
chrX_53253512_53254652	0.23	KDM5C	lysine (K)-specific demethylase 5C	276	0.9
chr9_99265682_99265833	0.23	HABP4	hyaluronan binding protein 4	53270	0.13
chr2_196548060_196548211	0.23	ENSG00000201813	.	12937	0.23
chr9_128411357_128411651	0.23	MAPKAP1	mitogen-activated protein kinase associated protein 1	1192	0.6
chr9_112813674_112813882	0.23	AKAP2	A kinase (PRKA) anchor protein 2	2802	0.39
chr5_77224879_77225030	0.22	TBCA	tubulin folding cofactor A	60350	0.14
chr7_115670465_115670618	0.22	TFEC	transcription factor EC	254	0.96
chr11_75535232_75535410	0.22	RP11-535A19.2		8870	0.1
chr4_146763857_146764008	0.22	RP11-181K12.2		9662	0.26
chr4_38162963_38163114	0.22	ENSG00000221495	.	77196	0.11
chr7_37755543_37755694	0.22	GPR141	G protein-coupled receptor 141	24378	0.21
chr9_132708790_132708941	0.22	RP11-409K20.6		13050	0.19
chr5_127688862_127689013	0.22	FBN2	fibrillin 2	14054	0.24
chr6_124159912_124160063	0.22	RP11-374A22.1		15602	0.24
chr5_67562966_67563283	0.22	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	12944	0.27
chr1_114517596_114517747	0.22	OLFML3	olfactomedin-like 3	4392	0.19
chr4_48701192_48701343	0.22	FRYL	FRY-like	18079	0.24
chr3_185445450_185445601	0.22	C3orf65	chromosome 3 open reading frame 65	14445	0.22
chr10_90754998_90755312	0.22	ACTA2	actin, alpha 2, smooth muscle, aorta	4008	0.17
chr13_100225293_100225444	0.22	CLYBL	citrate lyase beta like	33551	0.14
chr6_106500939_106501090	0.22	PRDM1	PR domain containing 1, with ZNF domain	33181	0.19
chr11_75584822_75585009	0.22	UVRAG	UV radiation resistance associated	4533	0.16
chr4_56501775_56502572	0.22	NMU	neuromedin U	253	0.93
chr9_21024320_21024568	0.21	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	7164	0.22
chr19_10697425_10697576	0.21	AP1M2	adaptor-related protein complex 1, mu 2 subunit	395	0.72
chr8_127513113_127513264	0.21	ENSG00000207138	.	3820	0.28
chr10_3807723_3807874	0.21	RP11-184A2.2		2309	0.32
chr13_70839300_70839451	0.21	KLHL1	kelch-like family member 1	156784	0.04
chr9_123958868_123959019	0.21	RAB14	RAB14, member RAS oncogene family	5204	0.17
chr2_101197927_101198078	0.21	ENSG00000238328	.	4071	0.2
chr7_38903515_38903666	0.21	VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	32644	0.22
chr6_111888477_111888628	0.21	TRAF3IP2	TRAF3 interacting protein 2	11	0.97
chr11_65886976_65887127	0.21	PACS1	phosphofurin acidic cluster sorting protein 1	18817	0.1
chrX_22863600_22863751	0.21	DDX53	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	154412	0.04
chr9_687749_687900	0.21	RP11-130C19.3		2269	0.34
chr17_56477664_56477815	0.21	RNF43	ring finger protein 43	2343	0.23
chr7_41478323_41478624	0.21	INHBA-AS1	INHBA antisense RNA 1	255041	0.02
chr19_8922272_8922597	0.20	CTD-2529P6.3		9743	0.14
chr2_173995675_173995826	0.20	MLTK	Mitogen-activated protein kinase kinase kinase MLT	40403	0.17
chr4_39033572_39034012	0.20	TMEM156	transmembrane protein 156	249	0.93
chr11_63915867_63916232	0.20	MACROD1	MACRO domain containing 1	17484	0.09
chr2_153323935_153324293	0.20	FMNL2	formin-like 2	132363	0.05
chr11_105890749_105891017	0.20	MSANTD4	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	2071	0.32
chr13_30168298_30169638	0.20	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	857	0.74
chr17_40739225_40739376	0.20	PSMC3IP	PSMC3 interacting protein	9451	0.08
chr22_40856327_40856478	0.20	MKL1	megakaryoblastic leukemia (translocation) 1	3020	0.24
chr15_59646896_59647047	0.20	RP11-356M20.3		5117	0.14
chr10_45123233_45123384	0.20	CXCL12	chemokine (C-X-C motif) ligand 12	242768	0.02
chr13_30947300_30947451	0.20	KATNAL1	katanin p60 subunit A-like 1	65754	0.12
chrX_13007277_13007565	0.20	TMSB4X	thymosin beta 4, X-linked	13644	0.22
chr15_33135515_33135666	0.19	FMN1	formin 1	44865	0.14
chr4_143252459_143252732	0.19	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	25498	0.28
chr5_24644888_24645378	0.19	CDH10	cadherin 10, type 2 (T2-cadherin)	46	0.99
chr10_53221961_53222112	0.19	RP11-539E19.2		159710	0.04
chr20_39135469_39135620	0.19	ENSG00000252434	.	90029	0.1
chr1_243420909_243421197	0.19	SDCCAG8	serologically defined colon cancer antigen 8	1681	0.33
chr10_76689232_76689383	0.19	KAT6B	K(lysine) acetyltransferase 6B	90849	0.07
chrX_131341527_131341678	0.19	RAP2C-AS1	RAP2C antisense RNA 1	9573	0.22
chr2_151124427_151124578	0.19	RND3	Rho family GTPase 3	217394	0.02
chr9_125798505_125798656	0.19	GPR21	G protein-coupled receptor 21	1774	0.31
chr6_157129169_157129320	0.19	RP11-230C9.3		27655	0.18
chr2_208602192_208602343	0.19	CCNYL1	cyclin Y-like 1	4731	0.16
chr4_123588404_123588555	0.18	IL21	interleukin 21	46255	0.14
chr4_71891789_71891940	0.18	DCK	deoxycytidine kinase	32509	0.21
chr12_94161563_94161714	0.18	RP11-887P2.5		30039	0.17
chr9_16679077_16679228	0.18	BNC2	basonuclin 2	25928	0.2
chr7_80704969_80705120	0.18	AC005008.2	Uncharacterized protein	99780	0.09
chr18_51736710_51736861	0.18	ENSG00000207233	.	11997	0.21
chr5_131014671_131014822	0.18	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	43817	0.18
chr12_10558293_10558444	0.18	KLRC4	killer cell lectin-like receptor subfamily C, member 4	3988	0.14
chr12_95347508_95347659	0.18	NDUFA12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	49893	0.15
chr14_25147155_25147306	0.18	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	43757	0.13
chr1_8360871_8361022	0.18	ENSG00000251977	.	8623	0.16
chr6_25968730_25968889	0.18	TRIM38	tripartite motif containing 38	5534	0.11
chr9_111075511_111075662	0.18	ENSG00000222512	.	45623	0.21
chr15_57520158_57520309	0.18	TCF12	transcription factor 12	8569	0.27
chr7_93366478_93366629	0.18	ENSG00000265423	.	20313	0.24
chr3_9745623_9746706	0.18	CPNE9	copine family member IX	654	0.62
chr5_75545047_75545198	0.18	RP11-466P24.6		62165	0.14
chr4_111821276_111821427	0.18	ENSG00000215961	.	39548	0.19
chrX_70293235_70293425	0.18	SNX12	sorting nexin 12	5057	0.13
chr11_3923942_3924093	0.17	STIM1	stromal interaction molecule 1	676	0.62
chr10_63595750_63596410	0.17	ARID5B	AT rich interactive domain 5B (MRF1-like)	64979	0.13
chr5_158445903_158446054	0.17	CTD-2363C16.2		33164	0.18
chr7_12729528_12729679	0.17	ARL4A	ADP-ribosylation factor-like 4A	2343	0.34
chr5_29222993_29223144	0.17	ENSG00000252601	.	152465	0.05
chr9_88953667_88953818	0.17	ZCCHC6	zinc finger, CCHC domain containing 6	4296	0.27
chr7_15720473_15720624	0.17	MEOX2	mesenchyme homeobox 2	5889	0.26
chr12_107774173_107774467	0.17	ENSG00000200897	.	5796	0.28
chr4_40516329_40516480	0.17	RBM47	RNA binding motif protein 47	156	0.96
chr9_81760516_81760667	0.17	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	426097	0.01
chr1_39329527_39329678	0.17	RP5-864K19.4		3847	0.16
chr4_36245078_36245884	0.17	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr5_54127651_54127802	0.17	ENSG00000221073	.	21050	0.24
chr10_122451233_122451392	0.17	WDR11-AS1	WDR11 antisense RNA 1	85084	0.09
chr4_124593202_124593353	0.17	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	272154	0.02
chr14_38889256_38889407	0.17	CLEC14A	C-type lectin domain family 14, member A	163757	0.04
chr11_36618151_36618302	0.17	RAG2	recombination activating gene 2	1560	0.34
chr13_108457167_108457318	0.17	FAM155A-IT1	FAM155A intronic transcript 1 (non-protein coding)	30557	0.22
chr18_56270622_56270891	0.17	ENSG00000252284	.	2893	0.22
chr2_109539318_109539469	0.17	CCDC138	coiled-coil domain containing 138	66009	0.12
chr2_102357284_102357468	0.17	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	42384	0.2
chr4_95562323_95562474	0.17	BMPR1B	bone morphogenetic protein receptor, type IB	116721	0.07
chr2_213976639_213976790	0.17	IKZF2	IKAROS family zinc finger 2 (Helios)	36639	0.21
chr11_10826698_10826955	0.16	EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	2183	0.2
chr19_45682453_45683430	0.16	BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	14	0.95
chr21_39847210_39847361	0.16	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	23060	0.27
chr1_195877260_195877411	0.16	ENSG00000265986	.	674276	0.0
chr7_6732804_6732968	0.16	ENSG00000265245	.	1278	0.34
chr5_17222098_17222777	0.16	BASP1	brain abundant, membrane attached signal protein 1	4768	0.2
chr5_114193091_114193242	0.16	RP11-492A10.1		189059	0.03
chr14_64804121_64804291	0.16	ESR2	estrogen receptor 2 (ER beta)	608	0.56
chr14_31116263_31116414	0.16	SCFD1	sec1 family domain containing 1	7355	0.25
chr6_157381110_157381404	0.16	RP1-137K2.2		59583	0.15
chr17_48393570_48393721	0.16	RP11-893F2.9		28429	0.09
chr2_74802682_74802833	0.16	LOXL3	lysyl oxidase-like 3	19940	0.09
chr21_27500577_27500761	0.16	APP	amyloid beta (A4) precursor protein	12109	0.22
chr16_79731835_79731986	0.16	ENSG00000221330	.	28276	0.25
chr3_107937522_107937673	0.16	IFT57	intraflagellar transport 57 homolog (Chlamydomonas)	3625	0.33
chr5_53912070_53912221	0.16	SNX18	sorting nexin 18	98552	0.08
chr5_131991447_131991948	0.16	AC004041.2		113	0.94
chr3_5343632_5343783	0.15	ENSG00000241227	.	48799	0.14
chrX_114276029_114276180	0.15	ENSG00000222122	.	9114	0.21
chr10_31603702_31603954	0.15	ENSG00000237036	.	4033	0.23
chr18_56282753_56282991	0.15	ALPK2	alpha-kinase 2	13317	0.15
chr4_164416977_164417128	0.15	TMA16	translation machinery associated 16 homolog (S. cerevisiae)	1192	0.5
chrX_64901585_64901736	0.15	MSN	moesin	14123	0.3
chr13_80441817_80441968	0.15	NDFIP2	Nedd4 family interacting protein 2	386304	0.01
chr2_178649432_178649708	0.15	AC012499.1		86352	0.08
chr18_63233244_63233395	0.15	CDH7	cadherin 7, type 2	184169	0.03
chr10_33240556_33240863	0.15	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	3882	0.33
chr7_116416437_116416588	0.15	MET	met proto-oncogene	717	0.73
chr2_177679359_177679510	0.15	ENSG00000206866	.	115384	0.06
chr6_152451471_152451622	0.15	SYNE1	spectrin repeat containing, nuclear envelope 1	37940	0.22
chr1_21276828_21277022	0.15	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	8814	0.23
chr16_12667643_12667794	0.15	CTD-3037G24.4		16167	0.18
chr3_112183991_112184142	0.15	BTLA	B and T lymphocyte associated	34139	0.19
chr1_98853949_98854194	0.15	ENSG00000221777	.	15130	0.31
chr20_13903186_13903337	0.15	ENSG00000221328	.	33242	0.17
chr15_80365779_80365947	0.15	ZFAND6	zinc finger, AN1-type domain 6	931	0.64
chr6_120831058_120831209	0.15	ENSG00000206857	.	16413	0.3
chr7_84267660_84267811	0.15	ENSG00000265050	.	27589	0.27
chr13_30415572_30415723	0.15	UBL3	ubiquitin-like 3	9174	0.3
chr15_70728001_70728152	0.15	ENSG00000200216	.	242501	0.02
chr2_66668625_66669005	0.15	AC092669.1		153	0.89
chr2_167042360_167042511	0.15	ENSG00000222376	.	4959	0.27
chr1_180396421_180396572	0.15	ENSG00000265435	.	11029	0.24
chr2_40611863_40612014	0.15	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	45482	0.19
chr4_114758520_114758671	0.15	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	75512	0.11
chr5_57787974_57788125	0.15	GAPT	GRB2-binding adaptor protein, transmembrane	785	0.66
chr8_115880767_115880918	0.15	TRPS1	trichorhinophalangeal syndrome I	623606	0.0
chr2_158643187_158643338	0.15	ACVR1	activin A receptor, type I	20246	0.22
chr18_59617014_59617243	0.15	RNF152	ring finger protein 152	55664	0.17
chr16_48325554_48325705	0.15	LONP2	lon peptidase 2, peroxisomal	42594	0.14
chr18_22925102_22925253	0.15	ZNF521	zinc finger protein 521	5980	0.3
chr17_30878109_30878260	0.15	RP11-466A19.5		21117	0.12
chr8_134512578_134512847	0.15	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	1086	0.67
chr9_10292066_10292217	0.14	PTPRD	protein tyrosine phosphatase, receptor type, D	258351	0.02
chr10_75668708_75669249	0.14	PLAU	plasminogen activator, urokinase	43	0.97
chr6_106962020_106962173	0.14	AIM1	absent in melanoma 1	2366	0.31
chr1_34368788_34368939	0.14	RP5-1007G16.1		27796	0.2
chr6_148650626_148650914	0.14	SASH1	SAM and SH3 domain containing 1	12959	0.24
chr18_63063126_63063277	0.14	CDH7	cadherin 7, type 2	354287	0.01
chr4_178235041_178235192	0.14	NEIL3	nei endonuclease VIII-like 3 (E. coli)	4126	0.26
chr4_26198805_26199180	0.14	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	33915	0.24
chr2_64320008_64320159	0.14	AC074289.1		50290	0.14
chr15_59223516_59223667	0.14	SLTM	SAFB-like, transcription modulator	2182	0.3
chr1_160678676_160678904	0.14	CD48	CD48 molecule	2803	0.22
chr6_138084606_138084757	0.14	ENSG00000207300	.	20830	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX8

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0009648	photoperiodism(GO:0009648)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.2	GO:0043551	regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0	0.1	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.0	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.1	GO:0060535	trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.3	GO:0032438	melanosome organization(GO:0032438)
0.0	0.1	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0071504	cellular response to heparin(GO:0071504)
0.0	0.1	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.3	GO:0007398	ectoderm development(GO:0007398)
0.0	0.1	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0071732	cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.1	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0002069	columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0031579	membrane raft organization(GO:0031579)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.1	GO:0071320	cellular response to cAMP(GO:0071320)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.0	GO:0001711	endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.1	GO:0018995	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	GO:0001527	microfibril(GO:0001527)
0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	GO:0005827	polar microtubule(GO:0005827)
0.1	GO:0051233	spindle midzone(GO:0051233)
0.1	GO:0042599	lamellar body(GO:0042599)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.1	GO:0005521	lamin binding(GO:0005521)
0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.2	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	GO:0043495	protein anchor(GO:0043495)
0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.1	GO:0070063	RNA polymerase binding(GO:0070063)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade