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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for LHX8

Z-value: 1.13

Motif logo

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Transcription factors associated with LHX8

Gene Symbol Gene ID Gene Info
LHX8
ENSG00000162624.10 LIM homeobox 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_75571987_75572138LHX8220570.1725840.225.8e-01Click!
chr1_75600688_75601584LHX85690.698057-0.215.9e-01Click!

Activity of the LHX8 motif across conditions

Conditions sorted by the z-value of the LHX8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_28373361_28373512 0.60 LINGO2
 leucine rich repeat and Ig domain containing 2
 296847
 0.01
chr7_76785964_76786115 0.49 CCDC146
 coiled-coil domain containing 146
 34105
 0.15
chr18_72647452_72647603 0.36 ZADH2
 zinc binding alcohol dehydrogenase domain containing 2
 269941
 0.02
chr1_227501047_227501198 0.34 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
 3761
 0.35
chr8_66868091_66868242 0.32 DNAJC5B
 DnaJ (Hsp40) homolog, subfamily C, member 5 beta
 65629
 0.13
chr2_233565064_233565215 0.31 GIGYF2
 GRB10 interacting GYF protein 2
 3077
 0.19
chr4_39570973_39571124 0.29 UGDH
 UDP-glucose 6-dehydrogenase
 41117
 0.11
chr10_4023404_4023555 0.29 KLF6
 Kruppel-like factor 6
 196006
 0.03
chr1_66806017_66806168 0.29 PDE4B
 phosphodiesterase 4B, cAMP-specific
 8220
 0.31
chr22_17598033_17598230 0.27 CECR6
 cat eye syndrome chromosome region, candidate 6
 4012
 0.17
chr22_41249705_41249922 0.26 ST13
 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
 789
 0.51
chrX_68835519_68835670 0.26 EDA
 ectodysplasin A
 317
 0.92
chr18_30563491_30563642 0.26 RP11-680N20.1
29527
 0.24
chr10_27312512_27312663 0.25 ANKRD26
 ankyrin repeat domain 26
 8979
 0.23
chr11_122502980_122503131 0.25 UBASH3B
 ubiquitin associated and SH3 domain containing B
 23328
 0.21
chr2_55986068_55986219 0.25 PNPT1
 polyribonucleotide nucleotidyltransferase 1
 65098
 0.11
chr9_3827440_3827591 0.25 RP11-252M18.3
48069
 0.17
chr2_231429944_231430095 0.25 AC010149.4
14629
 0.18
chr6_10522784_10522935 0.25 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 1275
 0.45
chr8_90031831_90031982 0.24 RP11-586K2.1
319386
 0.01
chr7_38400564_38400715 0.24 AMPH
 amphiphysin
 102074
 0.08
chr10_89692060_89692211 0.24 RP11-380G5.2
53686
 0.11
chr7_116341288_116341439 0.24 MET
 met proto-oncogene
 2224
 0.39
chr5_158301830_158301981 0.23 CTD-2363C16.1
108109
 0.07
chr18_12596428_12596579 0.23 SPIRE1
 spire-type actin nucleation factor 1
 56581
 0.09
chr14_105759141_105759292 0.23 BRF1
 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
 7589
 0.16
chr20_52726952_52727103 0.23 BCAS1
 breast carcinoma amplified sequence 1
 39723
 0.15
chr13_78109984_78110135 0.23 SCEL
 sciellin
 164
 0.97
chr2_242063252_242063403 0.23 PASK
 PAS domain containing serine/threonine kinase
 15683
 0.13
chr14_52867726_52867877 0.23 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 86688
 0.09
chr2_200778375_200778671 0.23 C2orf69
 chromosome 2 open reading frame 69
 2544
 0.27
chrX_53253512_53254652 0.23 KDM5C
 lysine (K)-specific demethylase 5C
 276
 0.9
chr9_99265682_99265833 0.23 HABP4
 hyaluronan binding protein 4
 53270
 0.13
chr2_196548060_196548211 0.23 ENSG00000201813
 .
 12937
 0.23
chr9_128411357_128411651 0.23 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 1192
 0.6
chr9_112813674_112813882 0.23 AKAP2
 A kinase (PRKA) anchor protein 2
 2802
 0.39
chr5_77224879_77225030 0.22 TBCA
 tubulin folding cofactor A
 60350
 0.14
chr7_115670465_115670618 0.22 TFEC
 transcription factor EC
 254
 0.96
chr11_75535232_75535410 0.22 RP11-535A19.2
8870
 0.1
chr4_146763857_146764008 0.22 RP11-181K12.2
9662
 0.26
chr4_38162963_38163114 0.22 ENSG00000221495
 .
 77196
 0.11
chr7_37755543_37755694 0.22 GPR141
 G protein-coupled receptor 141
 24378
 0.21
chr9_132708790_132708941 0.22 RP11-409K20.6
13050
 0.19
chr5_127688862_127689013 0.22 FBN2
 fibrillin 2
 14054
 0.24
chr6_124159912_124160063 0.22 RP11-374A22.1
15602
 0.24
chr5_67562966_67563283 0.22 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 12944
 0.27
chr1_114517596_114517747 0.22 OLFML3
 olfactomedin-like 3
 4392
 0.19
chr4_48701192_48701343 0.22 FRYL
 FRY-like
 18079
 0.24
chr3_185445450_185445601 0.22 C3orf65
 chromosome 3 open reading frame 65
 14445
 0.22
chr10_90754998_90755312 0.22 ACTA2
 actin, alpha 2, smooth muscle, aorta
 4008
 0.17
chr13_100225293_100225444 0.22 CLYBL
 citrate lyase beta like
 33551
 0.14
chr6_106500939_106501090 0.22 PRDM1
 PR domain containing 1, with ZNF domain
 33181
 0.19
chr11_75584822_75585009 0.22 UVRAG
 UV radiation resistance associated
 4533
 0.16
chr4_56501775_56502572 0.22 NMU
 neuromedin U
 253
 0.93
chr9_21024320_21024568 0.21 PTPLAD2
 protein tyrosine phosphatase-like A domain containing 2
 7164
 0.22
chr19_10697425_10697576 0.21 AP1M2
 adaptor-related protein complex 1, mu 2 subunit
 395
 0.72
chr8_127513113_127513264 0.21 ENSG00000207138
 .
 3820
 0.28
chr10_3807723_3807874 0.21 RP11-184A2.2
2309
 0.32
chr13_70839300_70839451 0.21 KLHL1
 kelch-like family member 1
 156784
 0.04
chr9_123958868_123959019 0.21 RAB14
 RAB14, member RAS oncogene family
 5204
 0.17
chr2_101197927_101198078 0.21 ENSG00000238328
 .
 4071
 0.2
chr7_38903515_38903666 0.21 VPS41
 vacuolar protein sorting 41 homolog (S. cerevisiae)
 32644
 0.22
chr6_111888477_111888628 0.21 TRAF3IP2
 TRAF3 interacting protein 2
 11
 0.97
chr11_65886976_65887127 0.21 PACS1
 phosphofurin acidic cluster sorting protein 1
 18817
 0.1
chrX_22863600_22863751 0.21 DDX53
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
 154412
 0.04
chr9_687749_687900 0.21 RP11-130C19.3
2269
 0.34
chr17_56477664_56477815 0.21 RNF43
 ring finger protein 43
 2343
 0.23
chr7_41478323_41478624 0.21 INHBA-AS1
 INHBA antisense RNA 1
 255041
 0.02
chr19_8922272_8922597 0.20 CTD-2529P6.3
9743
 0.14
chr2_173995675_173995826 0.20 MLTK
 Mitogen-activated protein kinase kinase kinase MLT
 40403
 0.17
chr4_39033572_39034012 0.20 TMEM156
 transmembrane protein 156
 249
 0.93
chr11_63915867_63916232 0.20 MACROD1
 MACRO domain containing 1
 17484
 0.09
chr2_153323935_153324293 0.20 FMNL2
 formin-like 2
 132363
 0.05
chr11_105890749_105891017 0.20 MSANTD4
 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
 2071
 0.32
chr13_30168298_30169638 0.20 SLC7A1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 857
 0.74
chr17_40739225_40739376 0.20 PSMC3IP
 PSMC3 interacting protein
 9451
 0.08
chr22_40856327_40856478 0.20 MKL1
 megakaryoblastic leukemia (translocation) 1
 3020
 0.24
chr15_59646896_59647047 0.20 RP11-356M20.3
5117
 0.14
chr10_45123233_45123384 0.20 CXCL12
 chemokine (C-X-C motif) ligand 12
 242768
 0.02
chr13_30947300_30947451 0.20 KATNAL1
 katanin p60 subunit A-like 1
 65754
 0.12
chrX_13007277_13007565 0.20 TMSB4X
 thymosin beta 4, X-linked
 13644
 0.22
chr15_33135515_33135666 0.19 FMN1
 formin 1
 44865
 0.14
chr4_143252459_143252732 0.19 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 25498
 0.28
chr5_24644888_24645378 0.19 CDH10
 cadherin 10, type 2 (T2-cadherin)
 46
 0.99
chr10_53221961_53222112 0.19 RP11-539E19.2
159710
 0.04
chr20_39135469_39135620 0.19 ENSG00000252434
 .
 90029
 0.1
chr1_243420909_243421197 0.19 SDCCAG8
 serologically defined colon cancer antigen 8
 1681
 0.33
chr10_76689232_76689383 0.19 KAT6B
 K(lysine) acetyltransferase 6B
 90849
 0.07
chrX_131341527_131341678 0.19 RAP2C-AS1
 RAP2C antisense RNA 1
 9573
 0.22
chr2_151124427_151124578 0.19 RND3
 Rho family GTPase 3
 217394
 0.02
chr9_125798505_125798656 0.19 GPR21
 G protein-coupled receptor 21
 1774
 0.31
chr6_157129169_157129320 0.19 RP11-230C9.3
27655
 0.18
chr2_208602192_208602343 0.19 CCNYL1
 cyclin Y-like 1
 4731
 0.16
chr4_123588404_123588555 0.18 IL21
 interleukin 21
 46255
 0.14
chr4_71891789_71891940 0.18 DCK
 deoxycytidine kinase
 32509
 0.21
chr12_94161563_94161714 0.18 RP11-887P2.5
30039
 0.17
chr9_16679077_16679228 0.18 BNC2
 basonuclin 2
 25928
 0.2
chr7_80704969_80705120 0.18 AC005008.2
 Uncharacterized protein
 99780
 0.09
chr18_51736710_51736861 0.18 ENSG00000207233
 .
 11997
 0.21
chr5_131014671_131014822 0.18 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 43817
 0.18
chr12_10558293_10558444 0.18 KLRC4
 killer cell lectin-like receptor subfamily C, member 4
 3988
 0.14
chr12_95347508_95347659 0.18 NDUFA12
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
 49893
 0.15
chr14_25147155_25147306 0.18 GZMB
 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
 43757
 0.13
chr1_8360871_8361022 0.18 ENSG00000251977
 .
 8623
 0.16
chr6_25968730_25968889 0.18 TRIM38
 tripartite motif containing 38
 5534
 0.11
chr9_111075511_111075662 0.18 ENSG00000222512
 .
 45623
 0.21
chr15_57520158_57520309 0.18 TCF12
 transcription factor 12
 8569
 0.27
chr7_93366478_93366629 0.18 ENSG00000265423
 .
 20313
 0.24
chr3_9745623_9746706 0.18 CPNE9
 copine family member IX
 654
 0.62
chr5_75545047_75545198 0.18 RP11-466P24.6
62165
 0.14
chr4_111821276_111821427 0.18 ENSG00000215961
 .
 39548
 0.19
chrX_70293235_70293425 0.18 SNX12
 sorting nexin 12
 5057
 0.13
chr11_3923942_3924093 0.17 STIM1
 stromal interaction molecule 1
 676
 0.62
chr10_63595750_63596410 0.17 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 64979
 0.13
chr5_158445903_158446054 0.17 CTD-2363C16.2
33164
 0.18
chr7_12729528_12729679 0.17 ARL4A
 ADP-ribosylation factor-like 4A
 2343
 0.34
chr5_29222993_29223144 0.17 ENSG00000252601
 .
 152465
 0.05
chr9_88953667_88953818 0.17 ZCCHC6
 zinc finger, CCHC domain containing 6
 4296
 0.27
chr7_15720473_15720624 0.17 MEOX2
 mesenchyme homeobox 2
 5889
 0.26
chr12_107774173_107774467 0.17 ENSG00000200897
 .
 5796
 0.28
chr4_40516329_40516480 0.17 RBM47
 RNA binding motif protein 47
 156
 0.96
chr9_81760516_81760667 0.17 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 426097
 0.01
chr1_39329527_39329678 0.17 RP5-864K19.4
3847
 0.16
chr4_36245078_36245884 0.17 ARAP2
 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
 80
 0.74
chr5_54127651_54127802 0.17 ENSG00000221073
 .
 21050
 0.24
chr10_122451233_122451392 0.17 WDR11-AS1
 WDR11 antisense RNA 1
 85084
 0.09
chr4_124593202_124593353 0.17 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 272154
 0.02
chr14_38889256_38889407 0.17 CLEC14A
 C-type lectin domain family 14, member A
 163757
 0.04
chr11_36618151_36618302 0.17 RAG2
 recombination activating gene 2
 1560
 0.34
chr13_108457167_108457318 0.17 FAM155A-IT1
 FAM155A intronic transcript 1 (non-protein coding)
 30557
 0.22
chr18_56270622_56270891 0.17 ENSG00000252284
 .
 2893
 0.22
chr2_109539318_109539469 0.17 CCDC138
 coiled-coil domain containing 138
 66009
 0.12
chr2_102357284_102357468 0.17 MAP4K4
 mitogen-activated protein kinase kinase kinase kinase 4
 42384
 0.2
chr4_95562323_95562474 0.17 BMPR1B
 bone morphogenetic protein receptor, type IB
 116721
 0.07
chr2_213976639_213976790 0.17 IKZF2
 IKAROS family zinc finger 2 (Helios)
 36639
 0.21
chr11_10826698_10826955 0.16 EIF4G2
 eukaryotic translation initiation factor 4 gamma, 2
 2183
 0.2
chr19_45682453_45683430 0.16 BLOC1S3
 biogenesis of lysosomal organelles complex-1, subunit 3
 14
 0.95
chr21_39847210_39847361 0.16 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 23060
 0.27
chr1_195877260_195877411 0.16 ENSG00000265986
 .
 674276
 0.0
chr7_6732804_6732968 0.16 ENSG00000265245
 .
 1278
 0.34
chr5_17222098_17222777 0.16 BASP1
 brain abundant, membrane attached signal protein 1
 4768
 0.2
chr5_114193091_114193242 0.16 RP11-492A10.1
189059
 0.03
chr14_64804121_64804291 0.16 ESR2
 estrogen receptor 2 (ER beta)
 608
 0.56
chr14_31116263_31116414 0.16 SCFD1
 sec1 family domain containing 1
 7355
 0.25
chr6_157381110_157381404 0.16 RP1-137K2.2
59583
 0.15
chr17_48393570_48393721 0.16 RP11-893F2.9
28429
 0.09
chr2_74802682_74802833 0.16 LOXL3
 lysyl oxidase-like 3
 19940
 0.09
chr21_27500577_27500761 0.16 APP
 amyloid beta (A4) precursor protein
 12109
 0.22
chr16_79731835_79731986 0.16 ENSG00000221330
 .
 28276
 0.25
chr3_107937522_107937673 0.16 IFT57
 intraflagellar transport 57 homolog (Chlamydomonas)
 3625
 0.33
chr5_53912070_53912221 0.16 SNX18
 sorting nexin 18
 98552
 0.08
chr5_131991447_131991948 0.16 AC004041.2
113
 0.94
chr3_5343632_5343783 0.15 ENSG00000241227
 .
 48799
 0.14
chrX_114276029_114276180 0.15 ENSG00000222122
 .
 9114
 0.21
chr10_31603702_31603954 0.15 ENSG00000237036
 .
 4033
 0.23
chr18_56282753_56282991 0.15 ALPK2
 alpha-kinase 2
 13317
 0.15
chr4_164416977_164417128 0.15 TMA16
 translation machinery associated 16 homolog (S. cerevisiae)
 1192
 0.5
chrX_64901585_64901736 0.15 MSN
 moesin
 14123
 0.3
chr13_80441817_80441968 0.15 NDFIP2
 Nedd4 family interacting protein 2
 386304
 0.01
chr2_178649432_178649708 0.15 AC012499.1
86352
 0.08
chr18_63233244_63233395 0.15 CDH7
 cadherin 7, type 2
 184169
 0.03
chr10_33240556_33240863 0.15 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 3882
 0.33
chr7_116416437_116416588 0.15 MET
 met proto-oncogene
 717
 0.73
chr2_177679359_177679510 0.15 ENSG00000206866
 .
 115384
 0.06
chr6_152451471_152451622 0.15 SYNE1
 spectrin repeat containing, nuclear envelope 1
 37940
 0.22
chr1_21276828_21277022 0.15 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 8814
 0.23
chr16_12667643_12667794 0.15 CTD-3037G24.4
16167
 0.18
chr3_112183991_112184142 0.15 BTLA
 B and T lymphocyte associated
 34139
 0.19
chr1_98853949_98854194 0.15 ENSG00000221777
 .
 15130
 0.31
chr20_13903186_13903337 0.15 ENSG00000221328
 .
 33242
 0.17
chr15_80365779_80365947 0.15 ZFAND6
 zinc finger, AN1-type domain 6
 931
 0.64
chr6_120831058_120831209 0.15 ENSG00000206857
 .
 16413
 0.3
chr7_84267660_84267811 0.15 ENSG00000265050
 .
 27589
 0.27
chr13_30415572_30415723 0.15 UBL3
 ubiquitin-like 3
 9174
 0.3
chr15_70728001_70728152 0.15 ENSG00000200216
 .
 242501
 0.02
chr2_66668625_66669005 0.15 AC092669.1
153
 0.89
chr2_167042360_167042511 0.15 ENSG00000222376
 .
 4959
 0.27
chr1_180396421_180396572 0.15 ENSG00000265435
 .
 11029
 0.24
chr2_40611863_40612014 0.15 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
 45482
 0.19
chr4_114758520_114758671 0.15 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 75512
 0.11
chr5_57787974_57788125 0.15 GAPT
 GRB2-binding adaptor protein, transmembrane
 785
 0.66
chr8_115880767_115880918 0.15 TRPS1
 trichorhinophalangeal syndrome I
 623606
 0.0
chr2_158643187_158643338 0.15 ACVR1
 activin A receptor, type I
 20246
 0.22
chr18_59617014_59617243 0.15 RNF152
 ring finger protein 152
 55664
 0.17
chr16_48325554_48325705 0.15 LONP2
 lon peptidase 2, peroxisomal
 42594
 0.14
chr18_22925102_22925253 0.15 ZNF521
 zinc finger protein 521
 5980
 0.3
chr17_30878109_30878260 0.15 RP11-466A19.5
21117
 0.12
chr8_134512578_134512847 0.15 ST3GAL1
 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
 1086
 0.67
chr9_10292066_10292217 0.14 PTPRD
 protein tyrosine phosphatase, receptor type, D
 258351
 0.02
chr10_75668708_75669249 0.14 PLAU
 plasminogen activator, urokinase
 43
 0.97
chr6_106962020_106962173 0.14 AIM1
 absent in melanoma 1
 2366
 0.31
chr1_34368788_34368939 0.14 RP5-1007G16.1
27796
 0.2
chr6_148650626_148650914 0.14 SASH1
 SAM and SH3 domain containing 1
 12959
 0.24
chr18_63063126_63063277 0.14 CDH7
 cadherin 7, type 2
 354287
 0.01
chr4_178235041_178235192 0.14 NEIL3
 nei endonuclease VIII-like 3 (E. coli)
 4126
 0.26
chr4_26198805_26199180 0.14 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 33915
 0.24
chr2_64320008_64320159 0.14 AC074289.1
50290
 0.14
chr15_59223516_59223667 0.14 SLTM
 SAFB-like, transcription modulator
 2182
 0.3
chr1_160678676_160678904 0.14 CD48
 CD48 molecule
 2803
 0.22
chr6_138084606_138084757 0.14 ENSG00000207300
 .
 20830
 0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0009648 photoperiodism(GO:0009648)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.1 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.0 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0 0.1 GO:0060535 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.3 GO:0032438 melanosome organization(GO:0032438)
0.0 0.1 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.1 GO:0006925 inflammatory cell apoptotic process(GO:0006925)
0.0 0.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.0 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0007398 ectoderm development(GO:0007398)
0.0 0.1 GO:0046398 UDP-glucuronate metabolic process(GO:0046398)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.1 GO:0071732 cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0 0.1 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.0 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0031579 membrane raft organization(GO:0031579)
0.0 0.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.0 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.0 GO:0001711 endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031082 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0018995 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.0 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.0 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.0 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.0 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.0 GO:0043495 protein anchor(GO:0043495)
0.0 0.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0070063 RNA polymerase binding(GO:0070063)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade