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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for LMX1B_MNX1_RAX2

Z-value: 0.53

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Transcription factors associated with LMX1B_MNX1_RAX2

Gene Symbol Gene ID Gene Info
LMX1B
ENSG00000136944.13 LIM homeobox transcription factor 1 beta
MNX1
ENSG00000130675.10 motor neuron and pancreas homeobox 1
RAX2
ENSG00000173976.11 retina and anterior neural fold homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr9_129377175_129377421LMX1B5500.6551030.442.4e-01Click!
chr9_129388182_129388507LMX1B115960.1583070.245.4e-01Click!
chr9_129388558_129388709LMX1B118850.157836-0.098.2e-01Click!
chr9_129376782_129376983LMX1B1340.9134360.078.5e-01Click!
chr7_156802935_156803420MNX11680.6857140.531.4e-01Click!
chr7_156802235_156802413MNX1670.9500260.531.4e-01Click!
chr7_156801299_156801450MNX13950.7891120.422.6e-01Click!
chr7_156801968_156802119MNX1620.9565880.216.0e-01Click!

Activity of the LMX1B_MNX1_RAX2 motif across conditions

Conditions sorted by the z-value of the LMX1B_MNX1_RAX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr14_91881184_91881623 0.24 CCDC88C
 coiled-coil domain containing 88C
 2287
 0.37
chr6_159071306_159071615 0.24 SYTL3
 synaptotagmin-like 3
 414
 0.83
chr2_213962198_213962349 0.24 IKZF2
 IKAROS family zinc finger 2 (Helios)
 51080
 0.16
chr16_71935673_71935824 0.23 IST1
 increased sodium tolerance 1 homolog (yeast)
 6256
 0.13
chr10_33425652_33425891 0.22 ENSG00000263576
 .
 38207
 0.16
chr2_204721096_204721247 0.22 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
 11338
 0.25
chr12_4385579_4385730 0.21 CCND2-AS1
 CCND2 antisense RNA 1
 304
 0.58
chr1_113164228_113164419 0.21 ST7L
 suppression of tumorigenicity 7 like
 2283
 0.19
chr10_677138_677289 0.20 RP11-809C18.3
2635
 0.23
chr9_92032170_92032321 0.20 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 1503
 0.49
chr14_35306917_35307068 0.19 ENSG00000251726
 .
 7574
 0.17
chr14_22968352_22968523 0.19 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 12266
 0.1
chrX_19815653_19816006 0.19 SH3KBP1
 SH3-domain kinase binding protein 1
 2040
 0.46
chr3_168442261_168442412 0.19 ENSG00000207717
 .
 172694
 0.04
chr1_226251298_226251924 0.19 H3F3A
 H3 histone, family 3A
 67
 0.97
chr1_180387724_180387875 0.19 ENSG00000265435
 .
 19726
 0.22
chr1_192546230_192546423 0.18 RGS1
 regulator of G-protein signaling 1
 1423
 0.45
chr13_99910339_99910626 0.18 GPR18
 G protein-coupled receptor 18
 146
 0.96
chr2_2650168_2650319 0.17 MYT1L
 myelin transcription factor 1-like
 315277
 0.01
chrY_15815919_15816489 0.17 TMSB4Y
 thymosin beta 4, Y-linked
 757
 0.72
chr13_84126063_84126363 0.17 ENSG00000222791
 .
 253911
 0.02
chr13_41236803_41237000 0.17 FOXO1
 forkhead box O1
 3833
 0.29
chr1_197730742_197731002 0.16 RP11-448G4.4
4423
 0.25
chr4_123820303_123820454 0.16 NUDT6
 nudix (nucleoside diphosphate linked moiety X)-type motif 6
 14065
 0.17
chr13_31309966_31310295 0.16 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 485
 0.88
chr8_27131821_27132033 0.16 STMN4
 stathmin-like 4
 15990
 0.18
chr21_35306376_35306527 0.16 LINC00649
 long intergenic non-protein coding RNA 649
 2933
 0.21
chr12_82826657_82826808 0.16 METTL25
 methyltransferase like 25
 33594
 0.21
chr7_129620661_129620812 0.16 ENSG00000263557
 .
 4851
 0.14
chr1_162205339_162205490 0.16 ENSG00000266144
 .
 78517
 0.08
chr15_96817385_96817602 0.15 NR2F2-AS1
 NR2F2 antisense RNA 1
 1732
 0.37
chr5_118653769_118653920 0.15 ENSG00000243333
 .
 11518
 0.19
chr1_114413652_114413958 0.15 PTPN22
 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
 515
 0.69
chr5_94384750_94385033 0.15 MCTP1
 multiple C2 domains, transmembrane 1
 31700
 0.22
chr1_1099465_1099616 0.15 ENSG00000207730
 .
 2944
 0.11
chr6_159464766_159465080 0.15 TAGAP
 T-cell activation RhoGTPase activating protein
 1127
 0.51
chr16_69598825_69599558 0.15 NFAT5
 nuclear factor of activated T-cells 5, tonicity-responsive
 194
 0.82
chr1_246488003_246488154 0.15 SMYD3-IT1
 SMYD3 intronic transcript 1 (non-protein coding)
 2338
 0.35
chr10_3514525_3515428 0.14 RP11-184A2.3
278283
 0.01
chr4_143488982_143489737 0.14 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 7537
 0.34
chr1_186292481_186292673 0.14 ENSG00000202025
 .
 11517
 0.17
chr13_41555714_41555943 0.14 ELF1
 E74-like factor 1 (ets domain transcription factor)
 590
 0.77
chr1_198627689_198627922 0.14 RP11-553K8.5
8385
 0.25
chrX_64889806_64890147 0.14 MSN
 moesin
 2439
 0.43
chr20_43608188_43608641 0.14 STK4
 serine/threonine kinase 4
 13247
 0.14
chr2_64441014_64441273 0.14 AC074289.1
7034
 0.28
chr11_104904746_104905919 0.14 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 508
 0.77
chr3_189510811_189510962 0.14 TP63
 tumor protein p63
 3296
 0.33
chr1_198615140_198615291 0.14 PTPRC
 protein tyrosine phosphatase, receptor type, C
 6923
 0.25
chr21_36772703_36772854 0.14 ENSG00000211590
 .
 320235
 0.01
chrX_54948821_54948972 0.14 TRO
 trophinin
 486
 0.79
chr9_137347658_137347902 0.14 RXRA
 retinoid X receptor, alpha
 49352
 0.15
chrX_25020829_25021251 0.14 ARX
 aristaless related homeobox
 13025
 0.26
chr3_13919763_13919914 0.13 WNT7A
 wingless-type MMTV integration site family, member 7A
 1780
 0.41
chr22_30040936_30041087 0.13 NF2
 neurofibromin 2 (merlin)
 41023
 0.11
chrX_20996388_20996539 0.13 ENSG00000206716
 .
 236292
 0.02
chr5_56496018_56496179 0.13 GPBP1
 GC-rich promoter binding protein 1
 13850
 0.23
chr15_60881660_60881911 0.13 RORA
 RAR-related orphan receptor A
 2955
 0.3
chr4_90226799_90226950 0.13 GPRIN3
 GPRIN family member 3
 2287
 0.45
chr6_37410160_37410312 0.13 CMTR1
 cap methyltransferase 1
 9240
 0.22
chr13_99910052_99910203 0.13 GPR18
 G protein-coupled receptor 18
 501
 0.81
chr6_30797258_30797409 0.13 ENSG00000202241
 .
 34694
 0.07
chr6_82470488_82470639 0.13 ENSG00000206886
 .
 3178
 0.26
chr1_169679248_169679951 0.13 SELL
 selectin L
 1240
 0.48
chr1_18010263_18010414 0.13 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 65489
 0.12
chr14_100535454_100535614 0.13 EVL
 Enah/Vasp-like
 2760
 0.21
chr14_22947593_22947744 0.12 TRAJ60
 T cell receptor alpha joining 60 (pseudogene)
 2372
 0.15
chr15_81597008_81597159 0.12 IL16
 interleukin 16
 5326
 0.21
chr4_38623548_38623699 0.12 RP11-617D20.1
2573
 0.31
chr9_128586563_128586792 0.12 PBX3
 pre-B-cell leukemia homeobox 3
 40873
 0.21
chr3_46411886_46412037 0.12 CCR5
 chemokine (C-C motif) receptor 5 (gene/pseudogene)
 328
 0.87
chrY_17633910_17634061 0.12 ENSG00000252664
 .
 540661
 0.0
chr11_119572371_119572522 0.12 PVRL1
 poliovirus receptor-related 1 (herpesvirus entry mediator C)
 26817
 0.16
chr12_9912992_9913534 0.12 CD69
 CD69 molecule
 234
 0.92
chr20_35575234_35575857 0.12 SAMHD1
 SAM domain and HD domain 1
 4566
 0.25
chr7_140014228_140014507 0.12 SLC37A3
 solute carrier family 37, member 3
 28922
 0.14
chr1_185284312_185284463 0.12 IVNS1ABP
 influenza virus NS1A binding protein
 2074
 0.35
chr7_26141262_26141558 0.12 ENSG00000266430
 .
 41451
 0.15
chr17_2286013_2286164 0.12 RP1-59D14.1
2053
 0.18
chr19_42390602_42391041 0.12 ARHGEF1
 Rho guanine nucleotide exchange factor (GEF) 1
 2306
 0.19
chr11_42259823_42259974 0.12 LRRC4C
 leucine rich repeat containing 4C
 778575
 0.0
chr4_170256258_170256409 0.12 SH3RF1
 SH3 domain containing ring finger 1
 64077
 0.14
chr2_194212623_194212914 0.12 NA
 NA
 > 106
 NA
chr13_38923188_38923622 0.12 UFM1
 ubiquitin-fold modifier 1
 583
 0.86
chr17_264289_264440 0.12 AC108004.3
550
 0.69
chr6_154568354_154568864 0.12 IPCEF1
 interaction protein for cytohesin exchange factors 1
 53
 0.99
chr15_94040362_94040513 0.12 ENSG00000212063
 .
 210885
 0.02
chr5_81074467_81075538 0.11 SSBP2
 single-stranded DNA binding protein 2
 27930
 0.25
chr2_28826434_28826585 0.11 PLB1
 phospholipase B1
 1723
 0.42
chr17_38018344_38018495 0.11 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 1960
 0.26
chr10_123458202_123458353 0.11 RP11-78A18.2
37541
 0.2
chr3_32998333_32998484 0.11 CCR4
 chemokine (C-C motif) receptor 4
 5342
 0.28
chr21_32559881_32560032 0.11 TIAM1
 T-cell lymphoma invasion and metastasis 1
 57417
 0.15
chrX_803799_804090 0.11 SHOX
 short stature homeobox
 212402
 0.02
chrY_753799_754090 0.11 NA
 NA
 > 106
 NA
chr5_106791734_106791885 0.11 EFNA5
 ephrin-A5
 214519
 0.02
chr1_200865204_200865355 0.11 C1orf106
 chromosome 1 open reading frame 106
 1330
 0.42
chr6_26198173_26198564 0.11 HIST1H3D
 histone cluster 1, H3d
 890
 0.22
chr2_37576303_37576454 0.11 QPCT
 glutaminyl-peptide cyclotransferase
 4526
 0.2
chr9_102849500_102849651 0.11 ERP44
 endoplasmic reticulum protein 44
 11747
 0.18
chr4_61665381_61665532 0.11 ENSG00000265829
 .
 122881
 0.06
chr14_99726303_99726510 0.11 AL109767.1
2879
 0.29
chr2_197032053_197032740 0.11 STK17B
 serine/threonine kinase 17b
 3328
 0.25
chr1_24862040_24862255 0.11 ENSG00000266551
 .
 5943
 0.18
chr20_58406416_58406567 0.11 ENSG00000238777
 .
 21292
 0.2
chr18_76745276_76745427 0.11 SALL3
 spalt-like transcription factor 3
 5076
 0.32
chr3_20050398_20050549 0.11 PP2D1
 protein phosphatase 2C-like domain containing 1
 3349
 0.22
chr6_106972751_106973424 0.11 AIM1
 absent in melanoma 1
 13357
 0.2
chr6_17703935_17704086 0.11 RP11-500C11.3
2478
 0.22
chr9_20242645_20242902 0.11 ENSG00000221744
 .
 52229
 0.16
chr18_3329157_3329308 0.11 MYL12B
 myosin, light chain 12B, regulatory
 66278
 0.09
chrY_2804248_2804778 0.11 ZFY
 zinc finger protein, Y-linked
 967
 0.67
chr17_47819247_47819793 0.11 FAM117A
 family with sequence similarity 117, member A
 17631
 0.14
chr17_40700695_40700889 0.11 HSD17B1
 hydroxysteroid (17-beta) dehydrogenase 1
 440
 0.63
chr1_25446753_25447069 0.11 RP4-706G24.1
87719
 0.07
chr6_138192975_138193775 0.11 RP11-356I2.4
4005
 0.25
chr16_18957307_18957806 0.11 ENSG00000265515
 .
 15952
 0.13
chr17_75456326_75456913 0.11 SEPT9
 septin 9
 4171
 0.18
chr1_43151006_43151188 0.11 YBX1
 Y box binding protein 1
 2439
 0.25
chr3_151961363_151961565 0.11 MBNL1
 muscleblind-like splicing regulator 1
 24365
 0.2
chr8_113941673_113941824 0.11 CSMD3
 CUB and Sushi multiple domains 3
 239477
 0.02
chr14_99708318_99708739 0.11 AL109767.1
20757
 0.2
chr2_143916963_143917114 0.10 RP11-190J23.1
12703
 0.25
chr17_76335263_76335414 0.10 SOCS3
 suppressor of cytokine signaling 3
 20817
 0.14
chr1_16483683_16483834 0.10 EPHA2
 EPH receptor A2
 1176
 0.29
chr12_27974048_27974199 0.10 ENSG00000201612
 .
 14800
 0.14
chr4_41188158_41188349 0.10 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 28222
 0.17
chr3_171848594_171848745 0.10 FNDC3B
 fibronectin type III domain containing 3B
 3905
 0.33
chr15_64767992_64768143 0.10 RP11-702L15.4
5615
 0.15
chr5_159900576_159900727 0.10 ENSG00000265237
 .
 758
 0.62
chr13_48988954_48989249 0.10 LPAR6
 lysophosphatidic acid receptor 6
 11942
 0.27
chr3_32996346_32996497 0.10 CCR4
 chemokine (C-C motif) receptor 4
 3355
 0.33
chr3_114010788_114010939 0.10 TIGIT
 T cell immunoreceptor with Ig and ITIM domains
 914
 0.57
chr21_32532372_32532523 0.10 TIAM1
 T-cell lymphoma invasion and metastasis 1
 29908
 0.23
chr7_106507057_106507208 0.10 PIK3CG
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
 1208
 0.59
chr4_124343109_124343622 0.10 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 22242
 0.29
chr15_30213010_30213162 0.10 TJP1
 tight junction protein 1
 47982
 0.15
chr3_71111068_71111292 0.10 FOXP1
 forkhead box P1
 2897
 0.41
chr4_95378812_95378990 0.10 PDLIM5
 PDZ and LIM domain 5
 2505
 0.43
chr15_34634999_34635332 0.10 NOP10
 NOP10 ribonucleoprotein
 159
 0.71
chr1_244504765_244505074 0.10 C1orf100
 chromosome 1 open reading frame 100
 11018
 0.25
chr12_65779210_65779361 0.10 MSRB3
 methionine sulfoxide reductase B3
 58630
 0.15
chr10_30745504_30745655 0.10 MAP3K8
 mitogen-activated protein kinase kinase kinase 8
 17828
 0.21
chr3_108543496_108543820 0.10 TRAT1
 T cell receptor associated transmembrane adaptor 1
 2039
 0.42
chr5_85275732_85275883 0.10 NBPF22P
 neuroblastoma breakpoint family, member 22, pseudogene
 302777
 0.01
chr10_129861850_129862130 0.10 PTPRE
 protein tyrosine phosphatase, receptor type, E
 16156
 0.26
chr22_31615175_31615326 0.10 ENSG00000199695
 .
 3589
 0.13
chr14_26016058_26016209 0.10 ENSG00000212270
 .
 259785
 0.02
chr1_150547532_150547683 0.10 MCL1
 myeloid cell leukemia sequence 1 (BCL2-related)
 4399
 0.09
chr8_112438072_112438223 0.10 ENSG00000222146
 .
 722907
 0.0
chr4_129450192_129450343 0.10 ENSG00000238802
 .
 226914
 0.02
chr17_33374319_33374470 0.10 RFFL
 ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
 5024
 0.13
chr15_52361483_52361634 0.10 CTD-2184D3.5
31162
 0.12
chr13_41227499_41227650 0.10 FOXO1
 forkhead box O1
 13160
 0.24
chr21_32555155_32555306 0.10 TIAM1
 T-cell lymphoma invasion and metastasis 1
 52691
 0.16
chr14_22966536_22967037 0.10 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 10615
 0.1
chr12_53773389_53773606 0.10 SP1
 Sp1 transcription factor
 463
 0.73
chr18_67822225_67822376 0.10 RTTN
 rotatin
 50662
 0.17
chr6_44899717_44900076 0.10 SUPT3H
 suppressor of Ty 3 homolog (S. cerevisiae)
 23351
 0.28
chr5_94951954_94952105 0.10 GPR150
 G protein-coupled receptor 150
 3753
 0.21
chr4_140587624_140588180 0.10 MGST2
 microsomal glutathione S-transferase 2
 913
 0.61
chr9_97864832_97864983 0.10 RP11-80I15.4
11083
 0.14
chr2_192623983_192624134 0.10 AC098872.3
34093
 0.19
chr15_101783225_101783409 0.09 CHSY1
 chondroitin sulfate synthase 1
 8820
 0.18
chr12_103834650_103834908 0.09 C12orf42
 chromosome 12 open reading frame 42
 54952
 0.15
chr1_100852790_100852941 0.09 ENSG00000216067
 .
 8534
 0.21
chr4_47491811_47491962 0.09 ATP10D
 ATPase, class V, type 10D
 4570
 0.24
chrX_31453419_31453570 0.09 ENSG00000252903
 .
 87185
 0.1
chr2_68961577_68961872 0.09 ARHGAP25
 Rho GTPase activating protein 25
 189
 0.96
chr14_22182172_22182323 0.09 OR4E2
 olfactory receptor, family 4, subfamily E, member 2
 48950
 0.13
chr7_32929941_32930760 0.09 KBTBD2
 kelch repeat and BTB (POZ) domain containing 2
 415
 0.87
chr7_150217655_150217806 0.09 GIMAP7
 GTPase, IMAP family member 7
 5812
 0.21
chr3_151963607_151963763 0.09 MBNL1
 muscleblind-like splicing regulator 1
 22144
 0.21
chr5_36951473_36951624 0.09 NIPBL
 Nipped-B homolog (Drosophila)
 74656
 0.12
chr10_64146533_64146728 0.09 ZNF365
 zinc finger protein 365
 11327
 0.25
chr12_47604114_47604265 0.09 PCED1B
 PC-esterase domain containing 1B
 5863
 0.23
chr8_65492553_65493166 0.09 BHLHE22
 basic helix-loop-helix family, member e22
 45
 0.97
chr11_64089315_64089466 0.09 PRDX5
 peroxiredoxin 5
 3736
 0.08
chr16_48642312_48642839 0.09 N4BP1
 NEDD4 binding protein 1
 1545
 0.4
chr6_22436672_22436823 0.09 HDGFL1
 hepatoma derived growth factor-like 1
 132931
 0.05
chr1_186288985_186289136 0.09 ENSG00000202025
 .
 8000
 0.18
chr2_192176773_192176924 0.09 MYO1B
 myosin IB
 35237
 0.19
chr18_3453699_3454909 0.09 TGIF1
 TGFB-induced factor homeobox 1
 532
 0.8
chr9_41432727_41433091 0.09 SPATA31A5
 SPATA31 subfamily A, member 5
 67770
 0.13
chr10_63999686_63999837 0.09 RTKN2
 rhotekin 2
 3739
 0.34
chr7_43688967_43689164 0.09 COA1
 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
 830
 0.67
chr4_39032194_39032374 0.09 TMEM156
 transmembrane protein 156
 1757
 0.38
chr17_78755045_78755196 0.09 RP11-28G8.1
24312
 0.21
chr2_174129320_174129481 0.09 MLK7-AS1
 MLK7 antisense RNA 1
 6948
 0.3
chr5_44684027_44684178 0.09 ENSG00000263556
 .
 32190
 0.23
chr4_176699040_176699191 0.09 GPM6A
 glycoprotein M6A
 9423
 0.24
chr19_42056193_42056486 0.09 CEACAM21
 carcinoembryonic antigen-related cell adhesion molecule 21
 453
 0.8
chr16_75182070_75182247 0.09 ZFP1
 ZFP1 zinc finger protein
 232
 0.91
chr6_10522420_10522571 0.09 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 911
 0.58
chr11_47535258_47535409 0.09 RP11-750H9.7
1108
 0.33
chrX_124911556_124911707 0.09 ENSG00000222518
 .
 114732
 0.07
chr9_100691376_100691527 0.09 C9orf156
 chromosome 9 open reading frame 156
 6599
 0.16
chr10_91151882_91152232 0.09 IFIT1
 interferon-induced protein with tetratricopeptide repeats 1
 246
 0.89
chr2_85515182_85515333 0.09 ENSG00000221579
 .
 10900
 0.13
chr2_61111507_61111691 0.09 REL
 v-rel avian reticuloendotheliosis viral oncogene homolog
 2808
 0.27

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of LMX1B_MNX1_RAX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1 0.2 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.3 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0060044 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0043921 modulation by host of viral transcription(GO:0043921) modulation by host of symbiont transcription(GO:0052472)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0044409 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.0 GO:0034135 regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.0 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.0 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0010957 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.0 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.0 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.0 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.0 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0000085 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.1 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.1 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.0 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.0 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.0 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.0 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.0 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.0 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.0 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.0 0.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.8 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.0 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression