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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for MECOM

Z-value: 1.74

Motif logo

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Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
MECOM
ENSG00000085276.13 MDS1 and EVI1 complex locus

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr3_168759646_168760009MECOM859950.107120-0.826.9e-03Click!
chr3_168959825_168960526MECOM268510.260979-0.791.1e-02Click!
chr3_168565062_168565213MECOM2806850.014488-0.791.1e-02Click!
chr3_168866954_168867233MECOM15710.565531-0.781.2e-02Click!
chr3_168714566_168714717MECOM1311810.057017-0.752.1e-02Click!

Activity of the MECOM motif across conditions

Conditions sorted by the z-value of the MECOM motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_138361112_138361415 1.48 PPP1R26-AS1
 PPP1R26 antisense RNA 1
 2832
 0.17
chr6_108143523_108143878 1.20 SCML4
 sex comb on midleg-like 4 (Drosophila)
 1816
 0.46
chrX_12990488_12990859 1.17 TMSB4X
 thymosin beta 4, X-linked
 2554
 0.33
chr12_67102775_67102926 1.05 GRIP1
 glutamate receptor interacting protein 1
 29925
 0.26
chr9_274295_274630 0.99 DOCK8
 dedicator of cytokinesis 8
 1392
 0.34
chr1_158902219_158902370 0.83 PYHIN1
 pyrin and HIN domain family, member 1
 936
 0.62
chr13_31309749_31309959 0.82 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 209
 0.96
chr15_81589438_81589936 0.82 IL16
 interleukin 16
 433
 0.84
chr7_138790255_138790726 0.80 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 3610
 0.26
chr3_111261912_111262220 0.80 CD96
 CD96 molecule
 1069
 0.62
chr1_27850058_27850297 0.77 RP1-159A19.4
2139
 0.29
chr19_14260226_14260973 0.76 LPHN1
 latrophilin 1
 3052
 0.14
chr1_158901738_158901918 0.75 PYHIN1
 pyrin and HIN domain family, member 1
 470
 0.84
chr3_108544304_108544541 0.72 TRAT1
 T cell receptor associated transmembrane adaptor 1
 2803
 0.36
chr1_158903723_158903936 0.69 PYHIN1
 pyrin and HIN domain family, member 1
 2471
 0.32
chr3_152002678_152002963 0.68 MBNL1
 muscleblind-like splicing regulator 1
 14374
 0.21
chr5_126098116_126098351 0.67 ENSG00000252185
 .
 7124
 0.23
chr10_15250983_15251323 0.67 RP11-25G10.2
28338
 0.18
chr16_3626426_3626694 0.66 NLRC3
 NLR family, CARD domain containing 3
 832
 0.54
chr5_110560941_110561277 0.66 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 1325
 0.51
chr6_10310725_10311140 0.64 ENSG00000221583
 .
 88663
 0.07
chr5_130590254_130590503 0.64 CDC42SE2
 CDC42 small effector 2
 9324
 0.28
chr1_160680712_160681035 0.63 CD48
 CD48 molecule
 720
 0.63
chr19_14143598_14143749 0.62 IL27RA
 interleukin 27 receptor, alpha
 1113
 0.26
chr4_143322143_143322556 0.62 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 30063
 0.27
chr4_143477803_143478104 0.61 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 3869
 0.39
chr1_197711455_197711606 0.60 DENND1B
 DENN/MADD domain containing 1B
 6763
 0.23
chr20_49134113_49134959 0.60 PTPN1
 protein tyrosine phosphatase, non-receptor type 1
 7616
 0.17
chr13_74276583_74277049 0.58 KLF12
 Kruppel-like factor 12
 292370
 0.01
chr20_56193926_56194226 0.58 ZBP1
 Z-DNA binding protein 1
 1374
 0.49
chr1_24830480_24830703 0.58 RCAN3
 RCAN family member 3
 1204
 0.45
chr3_196360349_196360500 0.58 LINC01063
 long intergenic non-protein coding RNA 1063
 966
 0.45
chr7_5481756_5481907 0.57 TNRC18
 trinucleotide repeat containing 18
 16786
 0.12
chr14_99736204_99736825 0.57 BCL11B
 B-cell CLL/lymphoma 11B (zinc finger protein)
 1051
 0.56
chr9_117691730_117691942 0.56 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
 861
 0.73
chr17_54857016_54857307 0.56 C17orf67
 chromosome 17 open reading frame 67
 36089
 0.15
chr9_128452520_128452671 0.56 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 16861
 0.25
chr11_134145279_134145568 0.56 GLB1L3
 galactosidase, beta 1-like 3
 1212
 0.41
chr1_209943004_209943387 0.56 TRAF3IP3
 TRAF3 interacting protein 3
 1235
 0.37
chr11_6765821_6765972 0.55 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 22785
 0.11
chr17_56414746_56414985 0.55 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 146
 0.91
chr4_38320095_38320594 0.55 ENSG00000221495
 .
 80110
 0.11
chrY_15863168_15863367 0.55 KALP
 Kallmann syndrome sequence pseudogene
 269
 0.94
chr19_59049459_59049613 0.53 ZBTB45
 zinc finger and BTB domain containing 45
 742
 0.4
chr7_150435434_150435585 0.53 GIMAP5
 GTPase, IMAP family member 5
 1073
 0.47
chr10_6623121_6623274 0.52 PRKCQ
 protein kinase C, theta
 934
 0.73
chr13_75897142_75897293 0.52 TBC1D4
 TBC1 domain family, member 4
 18450
 0.24
chr13_33607360_33607575 0.52 ENSG00000221677
 .
 8022
 0.24
chr3_150920478_150920863 0.52 GPR171
 G protein-coupled receptor 171
 309
 0.87
chr3_16327973_16328244 0.52 OXNAD1
 oxidoreductase NAD-binding domain containing 1
 17360
 0.16
chr3_32993605_32993756 0.51 CCR4
 chemokine (C-C motif) receptor 4
 614
 0.81
chr11_104903729_104903880 0.51 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 2036
 0.29
chr1_161035238_161035389 0.51 AL591806.1
 Uncharacterized protein
 342
 0.73
chr7_74074778_74074955 0.50 GTF2I
 general transcription factor IIi
 2509
 0.33
chr19_48747420_48747628 0.50 CARD8
 caspase recruitment domain family, member 8
 3204
 0.16
chr15_45005178_45005397 0.50 B2M
 beta-2-microglobulin
 1572
 0.31
chr14_71465889_71466177 0.50 PCNX
 pecanex homolog (Drosophila)
 13715
 0.29
chr7_150146102_150146542 0.50 GIMAP8
 GTPase, IMAP family member 8
 1396
 0.39
chr16_53407923_53408151 0.50 RP11-44F14.1
1042
 0.51
chr6_148556457_148556608 0.50 SASH1
 SAM and SH3 domain containing 1
 36908
 0.17
chr17_4847333_4847512 0.49 RNF167
 ring finger protein 167
 1276
 0.18
chr2_198170219_198170545 0.49 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 3139
 0.21
chr5_130603053_130603363 0.49 CDC42SE2
 CDC42 small effector 2
 3415
 0.35
chr1_239884533_239884684 0.49 CHRM3
 cholinergic receptor, muscarinic 3
 1765
 0.38
chr12_4385782_4386106 0.48 CCND2-AS1
 CCND2 antisense RNA 1
 594
 0.46
chr2_32893445_32893596 0.48 TTC27
 tetratricopeptide repeat domain 27
 10425
 0.24
chr2_68962051_68962936 0.48 ARHGAP25
 Rho GTPase activating protein 25
 479
 0.86
chrX_78203280_78203453 0.47 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 2448
 0.45
chr2_143890292_143890443 0.47 ARHGAP15
 Rho GTPase activating protein 15
 3484
 0.32
chr1_84556504_84556817 0.47 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 12833
 0.27
chr5_156535534_156535685 0.47 HAVCR2
 hepatitis A virus cellular receptor 2
 524
 0.71
chr6_5698222_5698373 0.47 RP1-256G22.2
2792
 0.41
chr16_63449342_63449493 0.46 RP11-96H17.3
348523
 0.01
chr14_90190957_90191587 0.46 ENSG00000200312
 .
 12417
 0.22
chr1_89733975_89734126 0.46 GBP5
 guanylate binding protein 5
 2496
 0.28
chr2_5768317_5769063 0.46 AC108025.2
62488
 0.12
chr7_37624737_37624888 0.46 GPR141
 G protein-coupled receptor 141
 98588
 0.07
chrX_9320133_9320359 0.45 TBL1X
 transducin (beta)-like 1X-linked
 111089
 0.07
chr14_22631179_22631341 0.45 ENSG00000238634
 .
 20373
 0.25
chr1_25946010_25946176 0.45 MAN1C1
 mannosidase, alpha, class 1C, member 1
 1752
 0.37
chr13_99909901_99910052 0.45 GPR18
 G protein-coupled receptor 18
 652
 0.73
chr11_65849243_65849558 0.45 PACS1
 phosphofurin acidic cluster sorting protein 1
 2044
 0.18
chr11_1865994_1866145 0.45 TNNI2
 troponin I type 2 (skeletal, fast)
 4645
 0.11
chr12_40009937_40010108 0.44 ABCD2
 ATP-binding cassette, sub-family D (ALD), member 2
 3531
 0.29
chr1_184940406_184940557 0.44 FAM129A
 family with sequence similarity 129, member A
 3201
 0.3
chr17_64670217_64670368 0.44 AC006947.1
2198
 0.33
chr12_806266_806417 0.44 NINJ2
 ninjurin 2
 33396
 0.14
chr10_121030498_121030649 0.44 ENSG00000242853
 .
 58204
 0.09
chr21_35066025_35066176 0.44 ITSN1
 intersectin 1 (SH3 domain protein)
 25002
 0.18
chr17_74656206_74656421 0.44 ENSG00000199735
 .
 3911
 0.11
chr1_114888226_114888377 0.44 TRIM33
 tripartite motif containing 33
 117557
 0.06
chr2_106473228_106473435 0.43 AC009505.2
129
 0.97
chr19_18209438_18209589 0.43 IL12RB1
 interleukin 12 receptor, beta 1
 113
 0.91
chr13_41591572_41591774 0.43 ELF1
 E74-like factor 1 (ets domain transcription factor)
 1777
 0.37
chr5_85693756_85693907 0.43 NBPF22P
 neuroblastoma breakpoint family, member 22, pseudogene
 115247
 0.07
chr3_43736623_43736774 0.42 ANO10
 anoctamin 10
 3612
 0.27
chr12_122075303_122075715 0.42 ORAI1
 ORAI calcium release-activated calcium modulator 1
 10788
 0.17
chr15_60289534_60289829 0.42 FOXB1
 forkhead box B1
 6740
 0.32
chr1_92950112_92951112 0.42 GFI1
 growth factor independent 1 transcription repressor
 1016
 0.65
chr1_198622591_198622742 0.42 RP11-553K8.5
13524
 0.23
chr22_40928059_40928879 0.42 MKL1
 megakaryoblastic leukemia (translocation) 1
 1346
 0.4
chr1_114413159_114413365 0.42 PTPN22
 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
 1058
 0.4
chr8_27177308_27177459 0.42 PTK2B
 protein tyrosine kinase 2 beta
 5479
 0.22
chr17_61917821_61917972 0.42 ENSG00000264756
 .
 553
 0.57
chr1_186291189_186291340 0.42 ENSG00000202025
 .
 10204
 0.17
chr1_2756934_2757086 0.42 TTC34
 tetratricopeptide repeat domain 34
 38724
 0.18
chr1_150082423_150082787 0.41 PLEKHO1
 pleckstrin homology domain containing, family O member 1
 38768
 0.11
chr7_46104168_46104319 0.41 ENSG00000239004
 .
 89206
 0.09
chr6_24935630_24936094 0.41 FAM65B
 family with sequence similarity 65, member B
 326
 0.92
chr20_57266602_57266883 0.41 NPEPL1
 aminopeptidase-like 1
 927
 0.53
chr2_204806282_204806433 0.41 ICOS
 inducible T-cell co-stimulator
 4854
 0.31
chr2_172182548_172182699 0.40 METTL8
 methyltransferase like 8
 13143
 0.26
chr15_72305963_72306114 0.40 ENSG00000222094
 .
 31486
 0.14
chr2_197031106_197031309 0.40 STK17B
 serine/threonine kinase 17b
 4517
 0.23
chr9_133641237_133641388 0.40 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 51945
 0.13
chr2_233948481_233948771 0.40 INPP5D
 inositol polyphosphate-5-phosphatase, 145kDa
 23437
 0.17
chr20_43607716_43607876 0.40 STK4
 serine/threonine kinase 4
 12629
 0.14
chr11_58340730_58341020 0.40 LPXN
 leupaxin
 2459
 0.23
chr2_86088659_86088948 0.39 ST3GAL5
 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
 5974
 0.2
chr1_19297080_19297231 0.39 IFFO2
 intermediate filament family orphan 2
 13975
 0.2
chr17_2162485_2162636 0.39 SMG6
 SMG6 nonsense mediated mRNA decay factor
 6865
 0.12
chr12_860591_861270 0.39 WNK1
 WNK lysine deficient protein kinase 1
 829
 0.66
chr5_133464157_133464308 0.39 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 4923
 0.24
chr12_80186674_80186825 0.39 PPP1R12A
 protein phosphatase 1, regulatory subunit 12A
 3821
 0.23
chr19_16195500_16195773 0.39 TPM4
 tropomyosin 4
 3103
 0.21
chr6_130543841_130543992 0.39 SAMD3
 sterile alpha motif domain containing 3
 42
 0.99
chr2_106412699_106412850 0.39 NCK2
 NCK adaptor protein 2
 20241
 0.25
chr1_100866151_100866481 0.39 ENSG00000216067
 .
 21985
 0.18
chr17_38718941_38719099 0.38 CCR7
 chemokine (C-C motif) receptor 7
 1755
 0.33
chr9_34647623_34647855 0.38 GALT
 galactose-1-phosphate uridylyltransferase
 1079
 0.27
chr5_130868153_130868304 0.38 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 288
 0.95
chr8_83511193_83511344 0.38 SNX16
 sorting nexin 16
 756167
 0.0
chr11_79861921_79862072 0.38 ENSG00000200146
 .
 377008
 0.01
chrX_13687718_13687869 0.38 TCEANC
 transcription elongation factor A (SII) N-terminal and central domain containing
 14379
 0.18
chr3_45706571_45706792 0.38 LIMD1-AS1
 LIMD1 antisense RNA 1
 23693
 0.16
chr13_48989293_48989444 0.38 LPAR6
 lysophosphatidic acid receptor 6
 11675
 0.28
chr13_22283635_22283786 0.38 FGF9
 fibroblast growth factor 9
 38188
 0.19
chr3_98239647_98239798 0.38 CLDND1
 claudin domain containing 1
 405
 0.76
chr7_26412308_26412459 0.38 AC004540.4
3509
 0.27
chr6_130460275_130460426 0.37 RP11-73O6.3
1009
 0.62
chr7_93145377_93145528 0.37 ENSG00000207656
 .
 32121
 0.15
chr4_26301131_26301282 0.37 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 20078
 0.28
chr5_39189662_39189905 0.37 FYB
 FYN binding protein
 13346
 0.27
chr1_26452753_26452998 0.37 PDIK1L
 PDLIM1 interacting kinase 1 like
 14535
 0.1
chr11_24068720_24068871 0.37 ENSG00000252519
 .
 197471
 0.03
chrX_28754918_28755069 0.37 IL1RAPL1
 interleukin 1 receptor accessory protein-like 1
 52468
 0.18
chr12_12041210_12041361 0.37 ETV6
 ets variant 6
 2414
 0.43
chr11_3856868_3857019 0.37 RHOG
 ras homolog family member G
 2154
 0.17
chr1_220527416_220527567 0.36 AC096644.1
 Uncharacterized protein
 80532
 0.09
chr10_30707556_30707739 0.36 MAP3K8
 mitogen-activated protein kinase kinase kinase 8
 15219
 0.19
chr11_60214184_60214345 0.36 MS4A1
 membrane-spanning 4-domains, subfamily A, member 1
 8961
 0.16
chr6_13681714_13682001 0.36 ENSG00000252966
 .
 1545
 0.36
chr5_156610422_156610951 0.36 ITK
 IL2-inducible T-cell kinase
 2849
 0.18
chr7_4045679_4045830 0.36 SDK1
 sidekick cell adhesion molecule 1
 55202
 0.18
chr8_142231340_142231491 0.36 SLC45A4
 solute carrier family 45, member 4
 7254
 0.16
chr12_10019991_10020525 0.36 RP11-290C10.1
632
 0.61
chr16_67610238_67610389 0.36 CTCF
 CCCTC-binding factor (zinc finger protein)
 14003
 0.09
chr11_118086318_118086469 0.36 AMICA1
 adhesion molecule, interacts with CXADR antigen 1
 787
 0.57
chr5_19531168_19531319 0.36 ENSG00000264928
 .
 204427
 0.03
chr5_96212217_96212581 0.36 ERAP2
 endoplasmic reticulum aminopeptidase 2
 189
 0.93
chr13_55186133_55186284 0.36 ENSG00000266699
 .
 193884
 0.03
chr12_76658709_76658860 0.36 ENSG00000223273
 .
 50747
 0.15
chr14_22678915_22679066 0.36 ENSG00000238634
 .
 68103
 0.12
chrX_115456567_115456718 0.36 ENSG00000207033
 .
 75471
 0.11
chr7_74277653_74277804 0.36 GTF2IRD2
 GTF2I repeat domain containing 2
 9881
 0.18
chr1_40849833_40850457 0.36 SMAP2
 small ArfGAP2
 9825
 0.18
chr17_29646389_29646953 0.36 CTD-2370N5.3
822
 0.44
chr12_56308050_56308201 0.36 WIBG
 within bgcn homolog (Drosophila)
 12771
 0.09
chr14_53158961_53159226 0.35 ERO1L
 ERO1-like (S. cerevisiae)
 3154
 0.22
chr20_56401161_56401312 0.35 ENSG00000263453
 .
 69214
 0.11
chr14_92858562_92858713 0.35 SLC24A4
 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
 16086
 0.26
chr14_98979115_98979283 0.35 ENSG00000241757
 .
 161198
 0.04
chr5_77591342_77591493 0.35 AP3B1
 adaptor-related protein complex 3, beta 1 subunit
 838
 0.63
chr19_48761528_48762054 0.35 CARD8
 caspase recruitment domain family, member 8
 2588
 0.17
chr3_164293580_164293731 0.35 ENSG00000221755
 .
 234526
 0.02
chr3_147945384_147945535 0.35 ENSG00000221457
 .
 146750
 0.05
chr2_11041716_11041867 0.35 KCNF1
 potassium voltage-gated channel, subfamily F, member 1
 10272
 0.21
chr1_198653684_198653835 0.35 RP11-553K8.5
17569
 0.24
chr1_12227882_12228546 0.35 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 1154
 0.44
chr2_175456985_175457136 0.35 WIPF1
 WAS/WASL interacting protein family, member 1
 5433
 0.19
chr8_56834515_56834666 0.35 ENSG00000216204
 .
 13070
 0.14
chr2_213963775_213963926 0.35 IKZF2
 IKAROS family zinc finger 2 (Helios)
 49503
 0.17
chr1_92269793_92270018 0.35 ENSG00000239794
 .
 25726
 0.22
chr19_3183746_3183954 0.35 NCLN
 nicalin
 1711
 0.25
chr13_43912465_43912616 0.35 ENOX1
 ecto-NOX disulfide-thiol exchanger 1
 22673
 0.29
chr5_61577589_61577740 0.35 KIF2A
 kinesin heavy chain member 2A
 24325
 0.24
chr5_159896012_159896214 0.35 ENSG00000265237
 .
 5296
 0.18
chr14_99731258_99732023 0.35 AL109767.1
2355
 0.32
chr11_122722660_122722811 0.34 CRTAM
 cytotoxic and regulatory T cell molecule
 10276
 0.21
chr16_11887784_11888260 0.34 ZC3H7A
 zinc finger CCCH-type containing 7A
 2361
 0.24
chr2_201238626_201239302 0.34 ENSG00000201649
 .
 1066
 0.5
chr2_201984006_201984490 0.34 CFLAR
 CASP8 and FADD-like apoptosis regulator
 1034
 0.43
chr1_167601517_167601668 0.34 RP3-455J7.4
1681
 0.33
chr11_118216429_118216580 0.34 CD3G
 CD3g molecule, gamma (CD3-TCR complex)
 1433
 0.27
chr14_74210572_74210776 0.34 ELMSAN1
 ELM2 and Myb/SANT-like domain containing 1
 3716
 0.15
chr8_131027767_131028262 0.34 FAM49B
 family with sequence similarity 49, member B
 637
 0.69
chr15_34620156_34620427 0.34 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 8754
 0.11
chr3_189552222_189552373 0.34 ENSG00000216058
 .
 4586
 0.3
chr4_57547352_57547821 0.34 HOPX
 HOP homeobox
 126
 0.97
chr2_54796628_54796779 0.34 SPTBN1
 spectrin, beta, non-erythrocytic 1
 11172
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.2 0.8 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1 0.5 GO:2000321 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.1 0.5 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.3 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.3 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1 0.5 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 0.5 GO:0002475 antigen processing and presentation via MHC class Ib(GO:0002475)
0.1 0.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.2 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 0.1 GO:0002363 alpha-beta T cell lineage commitment(GO:0002363)
0.1 0.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.7 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1 0.4 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.1 0.2 GO:0048302 regulation of isotype switching to IgG isotypes(GO:0048302)
0.1 0.5 GO:0002507 tolerance induction(GO:0002507)
0.1 0.1 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.4 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 0.2 GO:0001821 histamine secretion(GO:0001821)
0.1 0.2 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.2 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.2 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:1903077 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0 0.2 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.4 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0097300 necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0044557 relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0 0.1 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.4 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.2 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.2 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.9 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0032100 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.3 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 0.1 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.1 GO:0090382 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.1 GO:0035305 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.1 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.3 GO:0051155 positive regulation of striated muscle cell differentiation(GO:0051155)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.0 GO:0070602 centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.1 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0046398 UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.6 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0072583 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.2 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0050706 regulation of interleukin-1 beta secretion(GO:0050706)
0.0 0.1 GO:0032656 regulation of interleukin-13 production(GO:0032656)
0.0 0.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.0 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.2 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 0.0 GO:0050702 interleukin-1 beta secretion(GO:0050702)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0055023 positive regulation of cardiac muscle tissue growth(GO:0055023) positive regulation of cardiac muscle tissue development(GO:0055025) positive regulation of cardiac muscle cell proliferation(GO:0060045) positive regulation of heart growth(GO:0060421)
0.0 0.1 GO:0061756 leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.0 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.2 GO:0001881 receptor recycling(GO:0001881)
0.0 0.2 GO:0006554 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.0 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0042026 protein refolding(GO:0042026)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.1 GO:0002855 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0000303 response to superoxide(GO:0000303)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.1 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.0 GO:0032715 negative regulation of interleukin-6 production(GO:0032715)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.0 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 0.0 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.2 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.0 GO:0002676 chronic inflammatory response to antigenic stimulus(GO:0002439) regulation of chronic inflammatory response(GO:0002676) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0045822 negative regulation of heart contraction(GO:0045822)
0.0 0.1 GO:0021873 forebrain neuroblast division(GO:0021873) neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.6 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.1 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.0 GO:0022601 menstrual cycle phase(GO:0022601)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.6 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:0043276 anoikis(GO:0043276)
0.0 0.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0001662 behavioral fear response(GO:0001662)
0.0 0.2 GO:0006997 nucleus organization(GO:0006997)
0.0 0.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 1.6 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.0 GO:0015793 glycerol transport(GO:0015793)
0.0 0.2 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.0 GO:1904181 positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0 0.1 GO:1901222 activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.2 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.0 GO:0032239 regulation of nucleobase-containing compound transport(GO:0032239)
0.0 0.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.0 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.0 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.2 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.3 GO:0070585 protein localization to mitochondrion(GO:0070585) establishment of protein localization to mitochondrion(GO:0072655)
0.0 0.0 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0002606 positive regulation of antigen processing and presentation(GO:0002579) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.0 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.0 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.0 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.0 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0 0.0 GO:0051383 kinetochore organization(GO:0051383)
0.0 0.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.0 GO:0051832 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.0 GO:1903313 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0030903 notochord development(GO:0030903)
0.0 0.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.0 0.0 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.0 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.0 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.0 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.2 GO:0043487 regulation of RNA stability(GO:0043487)
0.0 0.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.0 GO:0046839 phospholipid dephosphorylation(GO:0046839)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042629 mast cell granule(GO:0042629)
0.1 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.8 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 0.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.0 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.0 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0042645 mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0030686 90S preribosome(GO:0030686)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0005657 replication fork(GO:0005657)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.0 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.3 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 0.6 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 1.0 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 0.5 GO:0031013 troponin I binding(GO:0031013)
0.1 0.3 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.6 GO:0005522 profilin binding(GO:0005522)
0.1 0.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 1.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.0 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.2 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.2 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.1 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.4 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0015368 calcium:cation antiporter activity(GO:0015368)
0.0 0.2 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.5 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.0 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.0 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.1 GO:0004437 obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.3 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.5 GO:0019210 kinase inhibitor activity(GO:0019210)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.0 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.0 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.0 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.0 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.1 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 0.3 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 3.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.5 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.2 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.1 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.1 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.6 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.6 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.1 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 0.3 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.0 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 0.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling