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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MECOM

Z-value: 1.74

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Transcription factors associated with MECOM

Gene Symbol	Gene ID	Gene Info
MECOM Ensembl NCBI GeneCards UniProt	ENSG00000085276.13	MECOM

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MECOM	chr3_168759646_168760009	85995	0.107120	-0.82	6.9e-03	Click!
MECOM	chr3_168959825_168960526	26851	0.260979	-0.79	1.1e-02	Click!
MECOM	chr3_168565062_168565213	280685	0.014488	-0.79	1.1e-02	Click!
MECOM	chr3_168866954_168867233	1571	0.565531	-0.78	1.2e-02	Click!
MECOM	chr3_168714566_168714717	131181	0.057017	-0.75	2.1e-02	Click!

Activity of the MECOM motif across conditions

Conditions sorted by the z-value of the MECOM motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_138361112_138361415	1.48	PPP1R26-AS1	PPP1R26 antisense RNA 1	2832	0.17
chr6_108143523_108143878	1.20	SCML4	sex comb on midleg-like 4 (Drosophila)	1816	0.46
chrX_12990488_12990859	1.17	TMSB4X	thymosin beta 4, X-linked	2554	0.33
chr12_67102775_67102926	1.05	GRIP1	glutamate receptor interacting protein 1	29925	0.26
chr9_274295_274630	0.99	DOCK8	dedicator of cytokinesis 8	1392	0.34
chr1_158902219_158902370	0.83	PYHIN1	pyrin and HIN domain family, member 1	936	0.62
chr13_31309749_31309959	0.82	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	209	0.96
chr15_81589438_81589936	0.82	IL16	interleukin 16	433	0.84
chr7_138790255_138790726	0.80	ZC3HAV1	zinc finger CCCH-type, antiviral 1	3610	0.26
chr3_111261912_111262220	0.80	CD96	CD96 molecule	1069	0.62
chr1_27850058_27850297	0.77	RP1-159A19.4		2139	0.29
chr19_14260226_14260973	0.76	LPHN1	latrophilin 1	3052	0.14
chr1_158901738_158901918	0.75	PYHIN1	pyrin and HIN domain family, member 1	470	0.84
chr3_108544304_108544541	0.72	TRAT1	T cell receptor associated transmembrane adaptor 1	2803	0.36
chr1_158903723_158903936	0.69	PYHIN1	pyrin and HIN domain family, member 1	2471	0.32
chr3_152002678_152002963	0.68	MBNL1	muscleblind-like splicing regulator 1	14374	0.21
chr5_126098116_126098351	0.67	ENSG00000252185	.	7124	0.23
chr10_15250983_15251323	0.67	RP11-25G10.2		28338	0.18
chr16_3626426_3626694	0.66	NLRC3	NLR family, CARD domain containing 3	832	0.54
chr5_110560941_110561277	0.66	CAMK4	calcium/calmodulin-dependent protein kinase IV	1325	0.51
chr6_10310725_10311140	0.64	ENSG00000221583	.	88663	0.07
chr5_130590254_130590503	0.64	CDC42SE2	CDC42 small effector 2	9324	0.28
chr1_160680712_160681035	0.63	CD48	CD48 molecule	720	0.63
chr19_14143598_14143749	0.62	IL27RA	interleukin 27 receptor, alpha	1113	0.26
chr4_143322143_143322556	0.62	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30063	0.27
chr4_143477803_143478104	0.61	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	3869	0.39
chr1_197711455_197711606	0.60	DENND1B	DENN/MADD domain containing 1B	6763	0.23
chr20_49134113_49134959	0.60	PTPN1	protein tyrosine phosphatase, non-receptor type 1	7616	0.17
chr13_74276583_74277049	0.58	KLF12	Kruppel-like factor 12	292370	0.01
chr20_56193926_56194226	0.58	ZBP1	Z-DNA binding protein 1	1374	0.49
chr1_24830480_24830703	0.58	RCAN3	RCAN family member 3	1204	0.45
chr3_196360349_196360500	0.58	LINC01063	long intergenic non-protein coding RNA 1063	966	0.45
chr7_5481756_5481907	0.57	TNRC18	trinucleotide repeat containing 18	16786	0.12
chr14_99736204_99736825	0.57	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	1051	0.56
chr9_117691730_117691942	0.56	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	861	0.73
chr17_54857016_54857307	0.56	C17orf67	chromosome 17 open reading frame 67	36089	0.15
chr9_128452520_128452671	0.56	MAPKAP1	mitogen-activated protein kinase associated protein 1	16861	0.25
chr11_134145279_134145568	0.56	GLB1L3	galactosidase, beta 1-like 3	1212	0.41
chr1_209943004_209943387	0.56	TRAF3IP3	TRAF3 interacting protein 3	1235	0.37
chr11_6765821_6765972	0.55	GVINP1	GTPase, very large interferon inducible pseudogene 1	22785	0.11
chr17_56414746_56414985	0.55	BZRAP1-AS1	BZRAP1 antisense RNA 1	146	0.91
chr4_38320095_38320594	0.55	ENSG00000221495	.	80110	0.11
chrY_15863168_15863367	0.55	KALP	Kallmann syndrome sequence pseudogene	269	0.94
chr19_59049459_59049613	0.53	ZBTB45	zinc finger and BTB domain containing 45	742	0.4
chr7_150435434_150435585	0.53	GIMAP5	GTPase, IMAP family member 5	1073	0.47
chr10_6623121_6623274	0.52	PRKCQ	protein kinase C, theta	934	0.73
chr13_75897142_75897293	0.52	TBC1D4	TBC1 domain family, member 4	18450	0.24
chr13_33607360_33607575	0.52	ENSG00000221677	.	8022	0.24
chr3_150920478_150920863	0.52	GPR171	G protein-coupled receptor 171	309	0.87
chr3_16327973_16328244	0.52	OXNAD1	oxidoreductase NAD-binding domain containing 1	17360	0.16
chr3_32993605_32993756	0.51	CCR4	chemokine (C-C motif) receptor 4	614	0.81
chr11_104903729_104903880	0.51	CASP1	caspase 1, apoptosis-related cysteine peptidase	2036	0.29
chr1_161035238_161035389	0.51	AL591806.1	Uncharacterized protein	342	0.73
chr7_74074778_74074955	0.50	GTF2I	general transcription factor IIi	2509	0.33
chr19_48747420_48747628	0.50	CARD8	caspase recruitment domain family, member 8	3204	0.16
chr15_45005178_45005397	0.50	B2M	beta-2-microglobulin	1572	0.31
chr14_71465889_71466177	0.50	PCNX	pecanex homolog (Drosophila)	13715	0.29
chr7_150146102_150146542	0.50	GIMAP8	GTPase, IMAP family member 8	1396	0.39
chr16_53407923_53408151	0.50	RP11-44F14.1		1042	0.51
chr6_148556457_148556608	0.50	SASH1	SAM and SH3 domain containing 1	36908	0.17
chr17_4847333_4847512	0.49	RNF167	ring finger protein 167	1276	0.18
chr2_198170219_198170545	0.49	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	3139	0.21
chr5_130603053_130603363	0.49	CDC42SE2	CDC42 small effector 2	3415	0.35
chr1_239884533_239884684	0.49	CHRM3	cholinergic receptor, muscarinic 3	1765	0.38
chr12_4385782_4386106	0.48	CCND2-AS1	CCND2 antisense RNA 1	594	0.46
chr2_32893445_32893596	0.48	TTC27	tetratricopeptide repeat domain 27	10425	0.24
chr2_68962051_68962936	0.48	ARHGAP25	Rho GTPase activating protein 25	479	0.86
chrX_78203280_78203453	0.47	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	2448	0.45
chr2_143890292_143890443	0.47	ARHGAP15	Rho GTPase activating protein 15	3484	0.32
chr1_84556504_84556817	0.47	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	12833	0.27
chr5_156535534_156535685	0.47	HAVCR2	hepatitis A virus cellular receptor 2	524	0.71
chr6_5698222_5698373	0.47	RP1-256G22.2		2792	0.41
chr16_63449342_63449493	0.46	RP11-96H17.3		348523	0.01
chr14_90190957_90191587	0.46	ENSG00000200312	.	12417	0.22
chr1_89733975_89734126	0.46	GBP5	guanylate binding protein 5	2496	0.28
chr2_5768317_5769063	0.46	AC108025.2		62488	0.12
chr7_37624737_37624888	0.46	GPR141	G protein-coupled receptor 141	98588	0.07
chrX_9320133_9320359	0.45	TBL1X	transducin (beta)-like 1X-linked	111089	0.07
chr14_22631179_22631341	0.45	ENSG00000238634	.	20373	0.25
chr1_25946010_25946176	0.45	MAN1C1	mannosidase, alpha, class 1C, member 1	1752	0.37
chr13_99909901_99910052	0.45	GPR18	G protein-coupled receptor 18	652	0.73
chr11_65849243_65849558	0.45	PACS1	phosphofurin acidic cluster sorting protein 1	2044	0.18
chr11_1865994_1866145	0.45	TNNI2	troponin I type 2 (skeletal, fast)	4645	0.11
chr12_40009937_40010108	0.44	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	3531	0.29
chr1_184940406_184940557	0.44	FAM129A	family with sequence similarity 129, member A	3201	0.3
chr17_64670217_64670368	0.44	AC006947.1		2198	0.33
chr12_806266_806417	0.44	NINJ2	ninjurin 2	33396	0.14
chr10_121030498_121030649	0.44	ENSG00000242853	.	58204	0.09
chr21_35066025_35066176	0.44	ITSN1	intersectin 1 (SH3 domain protein)	25002	0.18
chr17_74656206_74656421	0.44	ENSG00000199735	.	3911	0.11
chr1_114888226_114888377	0.44	TRIM33	tripartite motif containing 33	117557	0.06
chr2_106473228_106473435	0.43	AC009505.2		129	0.97
chr19_18209438_18209589	0.43	IL12RB1	interleukin 12 receptor, beta 1	113	0.91
chr13_41591572_41591774	0.43	ELF1	E74-like factor 1 (ets domain transcription factor)	1777	0.37
chr5_85693756_85693907	0.43	NBPF22P	neuroblastoma breakpoint family, member 22, pseudogene	115247	0.07
chr3_43736623_43736774	0.42	ANO10	anoctamin 10	3612	0.27
chr12_122075303_122075715	0.42	ORAI1	ORAI calcium release-activated calcium modulator 1	10788	0.17
chr15_60289534_60289829	0.42	FOXB1	forkhead box B1	6740	0.32
chr1_92950112_92951112	0.42	GFI1	growth factor independent 1 transcription repressor	1016	0.65
chr1_198622591_198622742	0.42	RP11-553K8.5		13524	0.23
chr22_40928059_40928879	0.42	MKL1	megakaryoblastic leukemia (translocation) 1	1346	0.4
chr1_114413159_114413365	0.42	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	1058	0.4
chr8_27177308_27177459	0.42	PTK2B	protein tyrosine kinase 2 beta	5479	0.22
chr17_61917821_61917972	0.42	ENSG00000264756	.	553	0.57
chr1_186291189_186291340	0.42	ENSG00000202025	.	10204	0.17
chr1_2756934_2757086	0.42	TTC34	tetratricopeptide repeat domain 34	38724	0.18
chr1_150082423_150082787	0.41	PLEKHO1	pleckstrin homology domain containing, family O member 1	38768	0.11
chr7_46104168_46104319	0.41	ENSG00000239004	.	89206	0.09
chr6_24935630_24936094	0.41	FAM65B	family with sequence similarity 65, member B	326	0.92
chr20_57266602_57266883	0.41	NPEPL1	aminopeptidase-like 1	927	0.53
chr2_204806282_204806433	0.41	ICOS	inducible T-cell co-stimulator	4854	0.31
chr2_172182548_172182699	0.40	METTL8	methyltransferase like 8	13143	0.26
chr15_72305963_72306114	0.40	ENSG00000222094	.	31486	0.14
chr2_197031106_197031309	0.40	STK17B	serine/threonine kinase 17b	4517	0.23
chr9_133641237_133641388	0.40	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	51945	0.13
chr2_233948481_233948771	0.40	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	23437	0.17
chr20_43607716_43607876	0.40	STK4	serine/threonine kinase 4	12629	0.14
chr11_58340730_58341020	0.40	LPXN	leupaxin	2459	0.23
chr2_86088659_86088948	0.39	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	5974	0.2
chr1_19297080_19297231	0.39	IFFO2	intermediate filament family orphan 2	13975	0.2
chr17_2162485_2162636	0.39	SMG6	SMG6 nonsense mediated mRNA decay factor	6865	0.12
chr12_860591_861270	0.39	WNK1	WNK lysine deficient protein kinase 1	829	0.66
chr5_133464157_133464308	0.39	TCF7	transcription factor 7 (T-cell specific, HMG-box)	4923	0.24
chr12_80186674_80186825	0.39	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	3821	0.23
chr19_16195500_16195773	0.39	TPM4	tropomyosin 4	3103	0.21
chr6_130543841_130543992	0.39	SAMD3	sterile alpha motif domain containing 3	42	0.99
chr2_106412699_106412850	0.39	NCK2	NCK adaptor protein 2	20241	0.25
chr1_100866151_100866481	0.39	ENSG00000216067	.	21985	0.18
chr17_38718941_38719099	0.38	CCR7	chemokine (C-C motif) receptor 7	1755	0.33
chr9_34647623_34647855	0.38	GALT	galactose-1-phosphate uridylyltransferase	1079	0.27
chr5_130868153_130868304	0.38	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	288	0.95
chr8_83511193_83511344	0.38	SNX16	sorting nexin 16	756167	0.0
chr11_79861921_79862072	0.38	ENSG00000200146	.	377008	0.01
chrX_13687718_13687869	0.38	TCEANC	transcription elongation factor A (SII) N-terminal and central domain containing	14379	0.18
chr3_45706571_45706792	0.38	LIMD1-AS1	LIMD1 antisense RNA 1	23693	0.16
chr13_48989293_48989444	0.38	LPAR6	lysophosphatidic acid receptor 6	11675	0.28
chr13_22283635_22283786	0.38	FGF9	fibroblast growth factor 9	38188	0.19
chr3_98239647_98239798	0.38	CLDND1	claudin domain containing 1	405	0.76
chr7_26412308_26412459	0.38	AC004540.4		3509	0.27
chr6_130460275_130460426	0.37	RP11-73O6.3		1009	0.62
chr7_93145377_93145528	0.37	ENSG00000207656	.	32121	0.15
chr4_26301131_26301282	0.37	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	20078	0.28
chr5_39189662_39189905	0.37	FYB	FYN binding protein	13346	0.27
chr1_26452753_26452998	0.37	PDIK1L	PDLIM1 interacting kinase 1 like	14535	0.1
chr11_24068720_24068871	0.37	ENSG00000252519	.	197471	0.03
chrX_28754918_28755069	0.37	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	52468	0.18
chr12_12041210_12041361	0.37	ETV6	ets variant 6	2414	0.43
chr11_3856868_3857019	0.37	RHOG	ras homolog family member G	2154	0.17
chr1_220527416_220527567	0.36	AC096644.1	Uncharacterized protein	80532	0.09
chr10_30707556_30707739	0.36	MAP3K8	mitogen-activated protein kinase kinase kinase 8	15219	0.19
chr11_60214184_60214345	0.36	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	8961	0.16
chr6_13681714_13682001	0.36	ENSG00000252966	.	1545	0.36
chr5_156610422_156610951	0.36	ITK	IL2-inducible T-cell kinase	2849	0.18
chr7_4045679_4045830	0.36	SDK1	sidekick cell adhesion molecule 1	55202	0.18
chr8_142231340_142231491	0.36	SLC45A4	solute carrier family 45, member 4	7254	0.16
chr12_10019991_10020525	0.36	RP11-290C10.1		632	0.61
chr16_67610238_67610389	0.36	CTCF	CCCTC-binding factor (zinc finger protein)	14003	0.09
chr11_118086318_118086469	0.36	AMICA1	adhesion molecule, interacts with CXADR antigen 1	787	0.57
chr5_19531168_19531319	0.36	ENSG00000264928	.	204427	0.03
chr5_96212217_96212581	0.36	ERAP2	endoplasmic reticulum aminopeptidase 2	189	0.93
chr13_55186133_55186284	0.36	ENSG00000266699	.	193884	0.03
chr12_76658709_76658860	0.36	ENSG00000223273	.	50747	0.15
chr14_22678915_22679066	0.36	ENSG00000238634	.	68103	0.12
chrX_115456567_115456718	0.36	ENSG00000207033	.	75471	0.11
chr7_74277653_74277804	0.36	GTF2IRD2	GTF2I repeat domain containing 2	9881	0.18
chr1_40849833_40850457	0.36	SMAP2	small ArfGAP2	9825	0.18
chr17_29646389_29646953	0.36	CTD-2370N5.3		822	0.44
chr12_56308050_56308201	0.36	WIBG	within bgcn homolog (Drosophila)	12771	0.09
chr14_53158961_53159226	0.35	ERO1L	ERO1-like (S. cerevisiae)	3154	0.22
chr20_56401161_56401312	0.35	ENSG00000263453	.	69214	0.11
chr14_92858562_92858713	0.35	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	16086	0.26
chr14_98979115_98979283	0.35	ENSG00000241757	.	161198	0.04
chr5_77591342_77591493	0.35	AP3B1	adaptor-related protein complex 3, beta 1 subunit	838	0.63
chr19_48761528_48762054	0.35	CARD8	caspase recruitment domain family, member 8	2588	0.17
chr3_164293580_164293731	0.35	ENSG00000221755	.	234526	0.02
chr3_147945384_147945535	0.35	ENSG00000221457	.	146750	0.05
chr2_11041716_11041867	0.35	KCNF1	potassium voltage-gated channel, subfamily F, member 1	10272	0.21
chr1_198653684_198653835	0.35	RP11-553K8.5		17569	0.24
chr1_12227882_12228546	0.35	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	1154	0.44
chr2_175456985_175457136	0.35	WIPF1	WAS/WASL interacting protein family, member 1	5433	0.19
chr8_56834515_56834666	0.35	ENSG00000216204	.	13070	0.14
chr2_213963775_213963926	0.35	IKZF2	IKAROS family zinc finger 2 (Helios)	49503	0.17
chr1_92269793_92270018	0.35	ENSG00000239794	.	25726	0.22
chr19_3183746_3183954	0.35	NCLN	nicalin	1711	0.25
chr13_43912465_43912616	0.35	ENOX1	ecto-NOX disulfide-thiol exchanger 1	22673	0.29
chr5_61577589_61577740	0.35	KIF2A	kinesin heavy chain member 2A	24325	0.24
chr5_159896012_159896214	0.35	ENSG00000265237	.	5296	0.18
chr14_99731258_99732023	0.35	AL109767.1		2355	0.32
chr11_122722660_122722811	0.34	CRTAM	cytotoxic and regulatory T cell molecule	10276	0.21
chr16_11887784_11888260	0.34	ZC3H7A	zinc finger CCCH-type containing 7A	2361	0.24
chr2_201238626_201239302	0.34	ENSG00000201649	.	1066	0.5
chr2_201984006_201984490	0.34	CFLAR	CASP8 and FADD-like apoptosis regulator	1034	0.43
chr1_167601517_167601668	0.34	RP3-455J7.4		1681	0.33
chr11_118216429_118216580	0.34	CD3G	CD3g molecule, gamma (CD3-TCR complex)	1433	0.27
chr14_74210572_74210776	0.34	ELMSAN1	ELM2 and Myb/SANT-like domain containing 1	3716	0.15
chr8_131027767_131028262	0.34	FAM49B	family with sequence similarity 49, member B	637	0.69
chr15_34620156_34620427	0.34	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	8754	0.11
chr3_189552222_189552373	0.34	ENSG00000216058	.	4586	0.3
chr4_57547352_57547821	0.34	HOPX	HOP homeobox	126	0.97
chr2_54796628_54796779	0.34	SPTBN1	spectrin, beta, non-erythrocytic 1	11172	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.2	0.8	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.5	GO:2000321	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.1	0.5	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.3	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.5	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.5	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.1	0.3	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.5	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.1	0.2	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.1	0.1	GO:0002363	alpha-beta T cell lineage commitment(GO:0002363)
0.1	0.3	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1	0.7	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.1	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1	0.4	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.1	0.2	GO:0048302	regulation of isotype switching to IgG isotypes(GO:0048302)
0.1	0.5	GO:0002507	tolerance induction(GO:0002507)
0.1	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.2	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.1	0.4	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.1	0.2	GO:0001821	histamine secretion(GO:0001821)
0.1	0.2	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.2	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.2	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:1903077	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.6	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.2	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.2	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.4	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.4	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.2	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0044557	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.4	GO:0060134	prepulse inhibition(GO:0060134)
0.0	0.2	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.2	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.2	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.9	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.3	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.3	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.1	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.1	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0035305	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.3	GO:0051155	positive regulation of striated muscle cell differentiation(GO:0051155)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.0	GO:0070602	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0046398	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.6	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.3	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0042992	negative regulation of transcription factor import into nucleus(GO:0042992)
0.0	0.1	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0050706	regulation of interleukin-1 beta secretion(GO:0050706)
0.0	0.1	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.0	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.2	GO:0036230	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.0	GO:0050702	interleukin-1 beta secretion(GO:0050702)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.2	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0055023	positive regulation of cardiac muscle tissue growth(GO:0055023) positive regulation of cardiac muscle tissue development(GO:0055025) positive regulation of cardiac muscle cell proliferation(GO:0060045) positive regulation of heart growth(GO:0060421)
0.0	0.1	GO:0061756	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.2	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.0	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.2	GO:0001881	receptor recycling(GO:0001881)
0.0	0.2	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.3	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0071459	protein localization to chromosome, centromeric region(GO:0071459)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.2	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.1	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0042026	protein refolding(GO:0042026)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0002855	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0000303	response to superoxide(GO:0000303)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.5	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.4	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	0.0	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.0	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0046021	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.2	GO:0019433	triglyceride catabolic process(GO:0019433)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0048148	behavioral response to cocaine(GO:0048148)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.2	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.0	0.0	GO:0002676	chronic inflammatory response to antigenic stimulus(GO:0002439) regulation of chronic inflammatory response(GO:0002676) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0045822	negative regulation of heart contraction(GO:0045822)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873) neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.6	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.1	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.0	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0022601	menstrual cycle phase(GO:0022601)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.6	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0071699	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0001662	behavioral fear response(GO:0001662)
0.0	0.2	GO:0006997	nucleus organization(GO:0006997)
0.0	0.2	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	1.6	GO:0043087	regulation of GTPase activity(GO:0043087)
0.0	0.0	GO:0015793	glycerol transport(GO:0015793)
0.0	0.2	GO:0010226	response to lithium ion(GO:0010226)
0.0	0.1	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.1	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.1	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.0	GO:1904181	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.1	GO:1901222	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.2	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0002456	T cell mediated immunity(GO:0002456)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:0032239	regulation of nucleobase-containing compound transport(GO:0032239)
0.0	0.2	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.0	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.2	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.1	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.2	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.3	GO:0070585	protein localization to mitochondrion(GO:0070585) establishment of protein localization to mitochondrion(GO:0072655)
0.0	0.0	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0002606	positive regulation of antigen processing and presentation(GO:0002579) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.3	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.0	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.0	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.0	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.0	GO:0051383	kinetochore organization(GO:0051383)
0.0	0.0	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.1	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.0	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:1903313	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0030903	notochord development(GO:0030903)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.1	GO:0009311	oligosaccharide metabolic process(GO:0009311)
0.0	0.0	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0010719	negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0	0.0	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.2	GO:0043487	regulation of RNA stability(GO:0043487)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.1	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.0	GO:0046839	phospholipid dephosphorylation(GO:0046839)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0042629	mast cell granule(GO:0042629)
0.1	0.8	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	0.2	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	0.5	GO:0042101	T cell receptor complex(GO:0042101)
0.1	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.6	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.2	GO:0005638	lamin filament(GO:0005638)
0.0	0.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.3	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.2	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.3	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.3	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.5	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.5	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.8	GO:0030175	filopodium(GO:0030175)
0.0	0.2	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0031306	intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0	0.2	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.0	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.2	GO:0000299	obsolete integral to membrane of membrane fraction(GO:0000299)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.4	GO:0042645	mitochondrial nucleoid(GO:0042645)
0.0	0.1	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.3	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.6	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0030686	90S preribosome(GO:0030686)
0.0	0.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	1.5	GO:0016607	nuclear speck(GO:0016607)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.3	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.2	GO:0005657	replication fork(GO:0005657)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.0	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.3	GO:0015030	Cajal body(GO:0015030)
0.0	0.2	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.6	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	1.0	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	0.5	GO:0031013	troponin I binding(GO:0031013)
0.1	0.3	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.3	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.5	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	0.4	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.1	0.6	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1	1.6	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	1.0	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.2	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.1	0.2	GO:0036002	pre-mRNA binding(GO:0036002)
0.1	0.2	GO:0004948	calcitonin receptor activity(GO:0004948)
0.1	0.2	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	1.0	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.5	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.4	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0015368	calcium:cation antiporter activity(GO:0015368)
0.0	0.2	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0015288	porin activity(GO:0015288)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.2	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.5	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.3	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.3	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.5	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.1	GO:0005549	odorant binding(GO:0005549)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.3	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.3	GO:0043022	ribosome binding(GO:0043022)
0.0	0.6	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.5	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.2	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.5	GO:0019210	kinase inhibitor activity(GO:0019210)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.2	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0052742	phosphatidylinositol kinase activity(GO:0052742)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.2	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.0	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.0	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.2	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	0.1	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	0.3	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	0.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	0.5	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	3.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	1.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.6	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	1.4	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.8	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.3	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.3	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.2	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.4	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	1.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	0.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	1.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.5	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.2	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.1	1.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.5	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.5	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	1.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.6	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.1	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	0.1	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.6	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.4	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.0	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.0	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.1	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.1	REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0	0.3	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.0	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	0.2	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling