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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MEF2C

Z-value: 0.74

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Transcription factors associated with MEF2C

Gene Symbol Gene ID Gene Info
MEF2C
ENSG00000081189.9 MEF2C

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
MEF2Cchr5_88178054_881784487130.5215190.881.7e-03Click!
MEF2Cchr5_88178493_881790751800.7175010.853.5e-03Click!
MEF2Cchr5_88180307_8818045830.9683080.827.4e-03Click!
MEF2Cchr5_88179673_881802544220.6738760.818.2e-03Click!
MEF2Cchr5_88121517_8812186012870.5677660.818.7e-03Click!

Activity of the MEF2C motif across conditions

Conditions sorted by the z-value of the MEF2C motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_155312257_155312697 0.40 AC009227.2
1473
 0.49
chr14_89769991_89770787 0.38 RP11-356K23.1
46240
 0.14
chr5_39399204_39399669 0.35 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 4934
 0.29
chr7_120631344_120631706 0.34 CPED1
 cadherin-like and PC-esterase domain containing 1
 1849
 0.35
chr4_41362274_41362647 0.34 LIMCH1
 LIM and calponin homology domains 1
 188
 0.96
chr20_50417404_50418104 0.34 SALL4
 spalt-like transcription factor 4
 1193
 0.55
chr12_66319641_66319906 0.32 AC090673.2
 Uncharacterized protein
 1806
 0.35
chr5_88081859_88082385 0.31 MEF2C
 myocyte enhancer factor 2C
 37483
 0.19
chr19_11305569_11305933 0.30 KANK2
 KN motif and ankyrin repeat domains 2
 117
 0.94
chr2_17699920_17700290 0.29 RAD51AP2
 RAD51 associated protein 2
 399
 0.89
chr11_12714851_12715219 0.29 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 17985
 0.26
chr1_50575996_50576351 0.28 ELAVL4
 ELAV like neuron-specific RNA binding protein 4
 795
 0.71
chr6_46458168_46458592 0.26 RCAN2
 regulator of calcineurin 2
 719
 0.62
chr11_43597772_43598095 0.26 ENSG00000199077
 .
 5011
 0.24
chr11_109842804_109842955 0.25 ZC3H12C
 zinc finger CCCH-type containing 12C
 121208
 0.07
chr10_62335914_62336175 0.25 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 3623
 0.38
chr2_197852125_197852688 0.25 ANKRD44
 ankyrin repeat domain 44
 12820
 0.25
chr3_66139685_66140118 0.24 SLC25A26
 solute carrier family 25 (S-adenosylmethionine carrier), member 26
 20616
 0.25
chr9_80641416_80641906 0.24 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 3859
 0.36
chr1_93818876_93819027 0.24 ENSG00000223745
 .
 7369
 0.19
chr4_86853777_86853998 0.24 ARHGAP24
 Rho GTPase activating protein 24
 2461
 0.32
chr3_137834054_137834699 0.24 DZIP1L
 DAZ interacting zinc finger protein 1-like
 75
 0.97
chr5_76012905_76013056 0.23 CTD-2384B11.2
940
 0.39
chr1_21348527_21348859 0.22 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 28702
 0.19
chr7_112124877_112125132 0.22 LSMEM1
 leucine-rich single-pass membrane protein 1
 3958
 0.27
chr1_184476918_184477069 0.22 GS1-115G20.1
99522
 0.07
chr17_73440408_73440614 0.22 KIAA0195
 KIAA0195
 3271
 0.13
chr7_5465289_5465565 0.22 TNRC18
 trinucleotide repeat containing 18
 382
 0.81
chr6_72205767_72206133 0.21 ENSG00000212099
 .
 42729
 0.17
chr10_134401745_134402170 0.21 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 19473
 0.23
chr5_52098224_52098443 0.21 CTD-2288O8.1
14473
 0.19
chr1_118679016_118679244 0.21 SPAG17
 sperm associated antigen 17
 48716
 0.18
chr5_65750356_65750571 0.21 MAST4
 microtubule associated serine/threonine kinase family member 4
 141713
 0.05
chr9_81322437_81322726 0.21 PSAT1
 phosphoserine aminotransferase 1
 410522
 0.01
chr1_229762768_229763169 0.21 URB2
 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
 987
 0.42
chr2_71134235_71134873 0.21 VAX2
 ventral anterior homeobox 2
 6834
 0.12
chr13_45011783_45011934 0.21 TSC22D1
 TSC22 domain family, member 1
 877
 0.72
chr1_170631765_170631991 0.20 PRRX1
 paired related homeobox 1
 397
 0.91
chr2_109257559_109258085 0.20 LIMS1
 LIM and senescent cell antigen-like domains 1
 13446
 0.22
chr9_98639144_98639295 0.20 ERCC6L2
 excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2
 1236
 0.48
chr1_234630809_234631231 0.19 TARBP1
 TAR (HIV-1) RNA binding protein 1
 16171
 0.21
chr6_25179503_25179654 0.19 ENSG00000222373
 .
 13063
 0.19
chr20_50575363_50575654 0.19 ENSG00000263659
 .
 18136
 0.22
chr14_56471482_56471749 0.19 ENSG00000212522
 .
 63546
 0.13
chr1_153701479_153701646 0.19 INTS3
 integrator complex subunit 3
 995
 0.31
chr9_130615735_130616098 0.19 ENG
 endoglin
 999
 0.31
chr20_19830571_19830722 0.19 RIN2
 Ras and Rab interactor 2
 36519
 0.19
chr16_84328151_84329018 0.19 WFDC1
 WAP four-disulfide core domain 1
 132
 0.94
chr22_22295066_22295319 0.18 PPM1F
 protein phosphatase, Mg2+/Mn2+ dependent, 1F
 163
 0.92
chr11_119134441_119134592 0.18 ENSG00000222249
 .
 25871
 0.09
chr10_33251129_33251359 0.18 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 967
 0.68
chr4_86396961_86397163 0.18 ARHGAP24
 Rho GTPase activating protein 24
 671
 0.83
chrX_39504439_39504590 0.18 ENSG00000263730
 .
 15956
 0.29
chr7_41738474_41738677 0.18 INHBA
 inhibin, beta A
 1632
 0.38
chr6_44509899_44510345 0.18 ENSG00000266619
 .
 106744
 0.06
chr5_6722325_6722630 0.18 PAPD7
 PAP associated domain containing 7
 7732
 0.28
chr6_106994674_106995055 0.18 AIM1
 absent in melanoma 1
 5835
 0.22
chr2_188445720_188445877 0.17 TFPI
 tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
 15311
 0.23
chr5_123498601_123499144 0.17 RP11-436H11.2
565652
 0.0
chr2_55345979_55346130 0.17 RTN4
 reticulon 4
 6297
 0.2
chr20_50180013_50180188 0.17 NFATC2
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
 730
 0.78
chr14_89552116_89552267 0.17 FOXN3
 forkhead box N3
 94897
 0.08
chr1_65398868_65399019 0.17 JAK1
 Janus kinase 1
 33244
 0.2
chr14_89632118_89632412 0.17 FOXN3
 forkhead box N3
 14823
 0.28
chr5_6687085_6687491 0.17 PAPD7
 PAP associated domain containing 7
 27430
 0.2
chr12_13325747_13326012 0.16 EMP1
 epithelial membrane protein 1
 23771
 0.21
chr17_13502555_13502706 0.16 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 2614
 0.37
chr5_111089862_111090126 0.16 NREP
 neuronal regeneration related protein
 1954
 0.36
chr3_112353843_112353994 0.16 CCDC80
 coiled-coil domain containing 80
 3026
 0.32
chr4_54230912_54231063 0.16 SCFD2
 sec1 family domain containing 2
 1241
 0.52
chr16_101341_101492 0.16 SNRNP25
 small nuclear ribonucleoprotein 25kDa (U11/U12)
 1594
 0.2
chr20_11871763_11872529 0.16 BTBD3
 BTB (POZ) domain containing 3
 171
 0.97
chr12_125340893_125341100 0.16 SCARB1
 scavenger receptor class B, member 1
 7333
 0.22
chr14_59332432_59332583 0.16 ENSG00000221427
 .
 94543
 0.09
chr2_33682993_33683144 0.16 RASGRP3
 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
 45
 0.99
chr20_1356402_1356657 0.16 RP11-314N13.3
14263
 0.13
chr7_143581670_143581927 0.15 FAM115A
 family with sequence similarity 115, member A
 665
 0.7
chr1_225879081_225879232 0.15 RP11-145A3.1
9150
 0.18
chr20_62485470_62485890 0.15 ABHD16B
 abhydrolase domain containing 16B
 6886
 0.08
chr13_80913760_80914290 0.15 SPRY2
 sprouty homolog 2 (Drosophila)
 218
 0.96
chr1_151173034_151173185 0.15 PIP5K1A
 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
 2058
 0.17
chr20_19991582_19991882 0.15 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 6028
 0.22
chr5_111071431_111071582 0.15 STARD4-AS1
 STARD4 antisense RNA 1
 5420
 0.22
chr4_170585829_170585980 0.15 CLCN3
 chloride channel, voltage-sensitive 3
 4691
 0.28
chr7_15791369_15791742 0.15 MEOX2
 mesenchyme homeobox 2
 65118
 0.14
chr16_65555872_65556144 0.15 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 399740
 0.01
chr17_57449383_57449649 0.15 ENSG00000263857
 .
 6072
 0.19
chr16_86775280_86775446 0.15 FOXL1
 forkhead box L1
 163248
 0.03
chr5_148796790_148796941 0.15 ENSG00000208035
 .
 11616
 0.13
chr11_27720025_27720176 0.15 BDNF
 brain-derived neurotrophic factor
 1114
 0.59
chr18_61496009_61496309 0.15 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
 42767
 0.13
chr19_11314227_11314401 0.15 CTC-510F12.2
10
 0.95
chr10_16870751_16871209 0.15 RSU1
 Ras suppressor protein 1
 11453
 0.28
chr9_100264063_100264279 0.15 TMOD1
 tropomodulin 1
 250
 0.92
chr1_24373488_24373760 0.15 RP11-293P20.2
6299
 0.15
chr10_74454607_74455259 0.14 MCU
 mitochondrial calcium uniporter
 2556
 0.25
chr1_120660257_120660493 0.14 ENSG00000207149
 .
 9187
 0.25
chr3_184934142_184934696 0.14 ENSG00000264614
 .
 36641
 0.14
chr7_16751263_16751414 0.14 AC073333.8
8185
 0.18
chr3_48080820_48081059 0.14 MAP4
 microtubule-associated protein 4
 23037
 0.18
chr16_81577563_81578015 0.14 CMIP
 c-Maf inducing protein
 48835
 0.17
chr6_154800458_154800845 0.14 CNKSR3
 CNKSR family member 3
 1026
 0.69
chr8_38205081_38205318 0.14 RP11-513D5.2
11700
 0.13
chr11_46360410_46360982 0.14 DGKZ
 diacylglycerol kinase, zeta
 548
 0.72
chr11_48102672_48102843 0.14 ENSG00000263693
 .
 15577
 0.22
chr5_36692416_36692567 0.14 CTD-2353F22.1
32784
 0.22
chr12_68932399_68933004 0.14 RAP1B
 RAP1B, member of RAS oncogene family
 71918
 0.11
chr18_3579974_3580125 0.14 ENSG00000238445
 .
 7008
 0.16
chr14_31664283_31664434 0.13 HECTD1
 HECT domain containing E3 ubiquitin protein ligase 1
 12331
 0.17
chr12_1697602_1697753 0.13 FBXL14
 F-box and leucine-rich repeat protein 14
 5654
 0.22
chr1_112058467_112058908 0.13 ADORA3
 adenosine A3 receptor
 12305
 0.12
chr10_65019032_65019264 0.13 JMJD1C
 jumonji domain containing 1C
 9678
 0.27
chr4_170190845_170191352 0.13 SH3RF1
 SH3 domain containing ring finger 1
 10
 0.99
chr4_77491396_77491547 0.13 ENSG00000263445
 .
 3250
 0.21
chr8_96443387_96443671 0.13 C8orf37
 chromosome 8 open reading frame 37
 162100
 0.04
chr5_111092293_111092530 0.13 NREP
 neuronal regeneration related protein
 463
 0.84
chr14_52121858_52122101 0.13 FRMD6
 FERM domain containing 6
 3281
 0.25
chr17_48366854_48367409 0.13 RP11-893F2.9
1915
 0.24
chr6_112572588_112572957 0.13 LAMA4
 laminin, alpha 4
 2915
 0.26
chr11_85429273_85429899 0.13 SYTL2
 synaptotagmin-like 2
 55
 0.97
chr21_17386302_17386519 0.13 ENSG00000252273
 .
 21419
 0.28
chr3_120216529_120216680 0.13 FSTL1
 follistatin-like 1
 46504
 0.16
chr15_68645247_68645398 0.13 FEM1B
 fem-1 homolog b (C. elegans)
 62772
 0.11
chr15_63510549_63510700 0.13 RAB8B
 RAB8B, member RAS oncogene family
 28819
 0.17
chr2_134894818_134895366 0.13 ENSG00000263813
 .
 10396
 0.24
chr4_74903675_74903826 0.13 CXCL3
 chemokine (C-X-C motif) ligand 3
 656
 0.62
chr19_16403865_16404198 0.13 CTD-2562J15.6
355
 0.85
chr1_8713025_8713176 0.13 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 3330
 0.34
chr2_136424709_136424860 0.13 ENSG00000207654
 .
 1817
 0.32
chr6_7697968_7698508 0.13 BMP6
 bone morphogenetic protein 6
 28792
 0.23
chr11_121941003_121941242 0.12 RP11-166D19.1
258
 0.92
chr5_76016889_76017182 0.12 CTD-2384B11.2
4995
 0.19
chr11_57529774_57530544 0.12 CTNND1
 catenin (cadherin-associated protein), delta 1
 869
 0.5
chr2_9124671_9124822 0.12 ENSG00000238888
 .
 5722
 0.26
chr9_102130669_102130820 0.12 ENSG00000222337
 .
 84440
 0.09
chr17_38280448_38280599 0.12 MSL1
 male-specific lethal 1 homolog (Drosophila)
 307
 0.83
chr9_94065254_94065575 0.12 AUH
 AU RNA binding protein/enoyl-CoA hydratase
 58763
 0.16
chr16_88449218_88449497 0.12 ZNF469
 zinc finger protein 469
 44522
 0.14
chr17_4403788_4403939 0.12 AC118754.4
894
 0.43
chr2_71356365_71356651 0.12 MCEE
 methylmalonyl CoA epimerase
 836
 0.37
chr2_149372705_149372856 0.12 EPC2
 enhancer of polycomb homolog 2 (Drosophila)
 29229
 0.24
chr1_17945358_17945612 0.12 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 636
 0.82
chr18_66505598_66505749 0.12 CCDC102B
 coiled-coil domain containing 102B
 1672
 0.41
chr18_53253875_53254048 0.12 TCF4
 transcription factor 4
 386
 0.91
chr6_4906745_4907027 0.12 CDYL
 chromodomain protein, Y-like
 16660
 0.25
chr1_78356045_78356196 0.12 NEXN-AS1
 NEXN antisense RNA 1
 896
 0.52
chr6_35687700_35688402 0.12 FKBP5
 FK506 binding protein 5
 8309
 0.12
chr1_109934140_109934542 0.12 SORT1
 sortilin 1
 1638
 0.33
chr21_46550403_46550801 0.12 ADARB1
 adenosine deaminase, RNA-specific, B1
 9787
 0.16
chr10_70821404_70821710 0.12 SRGN
 serglycin
 26317
 0.16
chr3_99679660_99679890 0.12 ENSG00000264897
 .
 3467
 0.34
chr18_32290997_32291170 0.12 DTNA
 dystrobrevin, alpha
 822
 0.73
chr20_32979012_32979163 0.12 ENSG00000201498
 .
 7016
 0.16
chr2_163154744_163154895 0.12 IFIH1
 interferon induced with helicase C domain 1
 20375
 0.19
chr2_232531310_232531749 0.12 ENSG00000239202
 .
 20545
 0.15
chr4_177648022_177648173 0.12 RP11-313E19.2
57325
 0.15
chr17_68292264_68292415 0.11 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 126663
 0.05
chr17_75316367_75316959 0.11 SEPT9
 septin 9
 268
 0.93
chr2_1746603_1747283 0.11 PXDN
 peroxidasin homolog (Drosophila)
 1271
 0.58
chr1_217308938_217309289 0.11 ESRRG
 estrogen-related receptor gamma
 1983
 0.51
chr1_208393211_208393379 0.11 PLXNA2
 plexin A2
 24370
 0.28
chr15_72563969_72564835 0.11 PARP6
 poly (ADP-ribose) polymerase family, member 6
 510
 0.73
chr16_68281342_68281493 0.11 PLA2G15
 phospholipase A2, group XV
 2122
 0.13
chr8_33456928_33457496 0.11 DUSP26
 dual specificity phosphatase 26 (putative)
 284
 0.9
chr2_238571219_238571370 0.11 LRRFIP1
 leucine rich repeat (in FLII) interacting protein 1
 29494
 0.17
chr6_17985230_17985553 0.11 KIF13A
 kinesin family member 13A
 2303
 0.42
chr13_51252397_51252695 0.11 DLEU7-AS1
 DLEU7 antisense RNA 1
 129446
 0.05
chr2_42443882_42444033 0.11 AC083949.1
46516
 0.15
chr6_5969178_5969395 0.11 NRN1
 neuritin 1
 37914
 0.18
chr20_17947911_17948977 0.11 SNX5
 sorting nexin 5
 657
 0.53
chr5_154138190_154138341 0.11 LARP1
 La ribonucleoprotein domain family, member 1
 1531
 0.39
chr14_75754220_75754694 0.11 FOS
 FBJ murine osteosarcoma viral oncogene homolog
 7561
 0.17
chr2_173258773_173258924 0.11 ITGA6
 integrin, alpha 6
 33234
 0.16
chr2_7934753_7934904 0.11 ENSG00000221255
 .
 217856
 0.02
chr18_9017410_9017607 0.11 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 85120
 0.08
chr19_35927435_35927735 0.11 FFAR2
 free fatty acid receptor 2
 11618
 0.11
chr21_32707517_32707668 0.11 TIAM1
 T-cell lymphoma invasion and metastasis 1
 9002
 0.31
chr9_114867139_114867290 0.11 ENSG00000222327
 .
 32863
 0.14
chrX_65384503_65384696 0.11 HEPH
 hephaestin
 392
 0.92
chr12_109569450_109569601 0.11 ACACB
 acetyl-CoA carboxylase beta
 362
 0.84
chr12_78482191_78482621 0.11 RP11-136F16.1
3111
 0.35
chr12_96606792_96606943 0.11 RP11-394J1.2
10884
 0.2
chr15_48009556_48010008 0.11 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 128
 0.98
chr16_67564286_67564635 0.11 FAM65A
 family with sequence similarity 65, member A
 766
 0.44
chr15_91272960_91273111 0.11 BLM
 Bloom syndrome, RecQ helicase-like
 12410
 0.14
chr19_8305457_8305834 0.11 CTD-3020H12.4
1113
 0.43
chr19_17790996_17791451 0.11 UNC13A
 unc-13 homolog A (C. elegans)
 4245
 0.17
chr4_124509999_124510276 0.11 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 189014
 0.03
chr5_23721482_23721633 0.11 PRDM9
 PR domain containing 9
 213833
 0.02
chr3_69788021_69788388 0.11 MITF
 microphthalmia-associated transcription factor
 382
 0.9
chr8_116675050_116675578 0.11 TRPS1
 trichorhinophalangeal syndrome I
 1409
 0.6
chr8_108644169_108644529 0.11 ANGPT1
 angiopoietin 1
 134066
 0.05
chr20_3993319_3993621 0.11 RNF24
 ring finger protein 24
 2566
 0.31
chr9_97951408_97952029 0.11 ENSG00000238746
 .
 16838
 0.19
chr19_3818575_3818945 0.11 MATK
 megakaryocyte-associated tyrosine kinase
 16633
 0.11
chr13_23489541_23489915 0.11 ENSG00000240341
 .
 36390
 0.2
chr1_227503732_227504041 0.10 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
 997
 0.69
chr5_102191445_102191792 0.10 PAM
 peptidylglycine alpha-amidating monooxygenase
 8623
 0.32
chr9_10208018_10208266 0.10 PTPRD
 protein tyrosine phosphatase, receptor type, D
 174352
 0.04
chr1_64980027_64980301 0.10 CACHD1
 cache domain containing 1
 43689
 0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of MEF2C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.1 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.3 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0031392 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0001553 luteinization(GO:0001553)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.0 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.1 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.0 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.0 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.1 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.0 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:1902603 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.0 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0031094 platelet dense tubular network(GO:0031094)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.0 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine