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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for MEF2D_MEF2A

Z-value: 1.20

Motif logo

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Transcription factors associated with MEF2D_MEF2A

Gene Symbol Gene ID Gene Info
MEF2D
ENSG00000116604.13 myocyte enhancer factor 2D
MEF2A
ENSG00000068305.13 myocyte enhancer factor 2A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr15_100027229_100027393MEF2A99410.2046390.791.1e-02Click!
chr15_99991178_99991413MEF2A260750.174136-0.693.8e-02Click!
chr15_100026519_100026720MEF2A92490.2068380.665.1e-02Click!
chr15_99982440_99982591MEF2A348550.1512250.617.8e-02Click!
chr15_100108821_100109055MEF2A22500.3631580.599.3e-02Click!
chr1_156466320_156466471MEF2D41340.1434670.826.6e-03Click!
chr1_156480380_156480531MEF2D98350.1155400.713.3e-02Click!
chr1_156458657_156458808MEF2D16590.256349-0.561.1e-01Click!
chr1_156466052_156466203MEF2D44020.1403800.551.2e-01Click!
chr1_156471272_156471435MEF2D7330.543760-0.541.3e-01Click!

Activity of the MEF2D_MEF2A motif across conditions

Conditions sorted by the z-value of the MEF2D_MEF2A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr5_88081859_88082385 0.90 MEF2C
 myocyte enhancer factor 2C
 37483
 0.19
chr3_112353843_112353994 0.83 CCDC80
 coiled-coil domain containing 80
 3026
 0.32
chr3_66139685_66140118 0.72 SLC25A26
 solute carrier family 25 (S-adenosylmethionine carrier), member 26
 20616
 0.25
chr7_120631344_120631706 0.67 CPED1
 cadherin-like and PC-esterase domain containing 1
 1849
 0.35
chr16_86775280_86775446 0.63 FOXL1
 forkhead box L1
 163248
 0.03
chr2_155312257_155312697 0.63 AC009227.2
1473
 0.49
chr11_43597772_43598095 0.60 ENSG00000199077
 .
 5011
 0.24
chr1_151173034_151173185 0.59 PIP5K1A
 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
 2058
 0.17
chr5_39399204_39399669 0.51 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 4934
 0.29
chr1_17945358_17945612 0.51 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 636
 0.82
chr2_17699920_17700290 0.50 RAD51AP2
 RAD51 associated protein 2
 399
 0.89
chr13_94996950_94997101 0.49 ENSG00000212057
 .
 120619
 0.06
chr12_109219039_109219464 0.47 SSH1
 slingshot protein phosphatase 1
 811
 0.57
chr17_13502555_13502706 0.45 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 2614
 0.37
chr3_48597891_48598569 0.45 PFKFB4
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
 332
 0.77
chr1_234630809_234631231 0.45 TARBP1
 TAR (HIV-1) RNA binding protein 1
 16171
 0.21
chr11_85429273_85429899 0.44 SYTL2
 synaptotagmin-like 2
 55
 0.97
chr7_112124877_112125132 0.44 LSMEM1
 leucine-rich single-pass membrane protein 1
 3958
 0.27
chr14_89769991_89770787 0.43 RP11-356K23.1
46240
 0.14
chr3_99357829_99358140 0.43 COL8A1
 collagen, type VIII, alpha 1
 530
 0.85
chr19_11305569_11305933 0.42 KANK2
 KN motif and ankyrin repeat domains 2
 117
 0.94
chr1_170632786_170633084 0.42 PRRX1
 paired related homeobox 1
 112
 0.98
chr1_157962818_157962980 0.41 KIRREL
 kin of IRRE like (Drosophila)
 164
 0.96
chr17_57564845_57564996 0.41 ENSG00000200889
 .
 49940
 0.12
chr16_88449218_88449497 0.41 ZNF469
 zinc finger protein 469
 44522
 0.14
chr1_24373488_24373760 0.39 RP11-293P20.2
6299
 0.15
chr9_130615735_130616098 0.38 ENG
 endoglin
 999
 0.31
chr5_65750356_65750571 0.38 MAST4
 microtubule associated serine/threonine kinase family member 4
 141713
 0.05
chr9_81322437_81322726 0.37 PSAT1
 phosphoserine aminotransferase 1
 410522
 0.01
chr3_145968218_145968873 0.37 PLSCR4
 phospholipid scramblase 4
 109
 0.98
chr10_134401745_134402170 0.37 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 19473
 0.23
chr4_41362274_41362647 0.37 LIMCH1
 LIM and calponin homology domains 1
 188
 0.96
chr2_55226424_55226816 0.37 RTN4
 reticulon 4
 10965
 0.21
chr14_34145464_34145720 0.37 NPAS3
 neuronal PAS domain protein 3
 58855
 0.17
chr20_32979012_32979163 0.36 ENSG00000201498
 .
 7016
 0.16
chr6_121760422_121760623 0.36 GJA1
 gap junction protein, alpha 1, 43kDa
 3684
 0.22
chr11_109842804_109842955 0.36 ZC3H12C
 zinc finger CCCH-type containing 12C
 121208
 0.07
chr9_98639144_98639295 0.36 ERCC6L2
 excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2
 1236
 0.48
chr1_229762768_229763169 0.35 URB2
 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
 987
 0.42
chr1_224805949_224806359 0.35 CNIH3
 cornichon family AMPA receptor auxiliary protein 3
 2159
 0.29
chr5_132385127_132385278 0.35 HSPA4
 heat shock 70kDa protein 4
 2452
 0.27
chr13_45011783_45011934 0.35 TSC22D1
 TSC22 domain family, member 1
 877
 0.72
chr6_46458168_46458592 0.34 RCAN2
 regulator of calcineurin 2
 719
 0.62
chr2_85389562_85389713 0.34 TCF7L1-IT1
 TCF7L1 intronic transcript 1 (non-protein coding)
 23895
 0.15
chr1_93818876_93819027 0.34 ENSG00000223745
 .
 7369
 0.19
chr12_9268515_9268666 0.34 A2M
 alpha-2-macroglobulin
 163
 0.95
chr5_15499822_15500142 0.34 FBXL7
 F-box and leucine-rich repeat protein 7
 323
 0.94
chr21_30504177_30504355 0.33 MAP3K7CL
 MAP3K7 C-terminal like
 688
 0.61
chr1_50575996_50576351 0.33 ELAVL4
 ELAV like neuron-specific RNA binding protein 4
 795
 0.71
chrX_69700453_69700680 0.33 DLG3-AS1
 DLG3 antisense RNA 1
 24722
 0.14
chr5_174673965_174674120 0.32 DRD1
 dopamine receptor D1
 197169
 0.03
chr2_179728640_179728888 0.32 CCDC141
 coiled-coil domain containing 141
 20914
 0.17
chr7_90085000_90085151 0.32 CDK14
 cyclin-dependent kinase 14
 10663
 0.23
chr18_3579974_3580125 0.31 ENSG00000238445
 .
 7008
 0.16
chr5_14146856_14147086 0.31 TRIO
 trio Rho guanine nucleotide exchange factor
 3142
 0.4
chr4_55095719_55096018 0.31 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 142
 0.98
chr2_97018640_97018821 0.31 NCAPH
 non-SMC condensin I complex, subunit H
 11488
 0.15
chr2_71356365_71356651 0.31 MCEE
 methylmalonyl CoA epimerase
 836
 0.37
chr3_137834054_137834699 0.31 DZIP1L
 DAZ interacting zinc finger protein 1-like
 75
 0.97
chr2_197852125_197852688 0.31 ANKRD44
 ankyrin repeat domain 44
 12820
 0.25
chr4_15011908_15012097 0.30 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 6442
 0.31
chr20_19991582_19991882 0.30 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 6028
 0.22
chr4_86747653_86747804 0.30 ARHGAP24
 Rho GTPase activating protein 24
 1170
 0.61
chr2_55345979_55346130 0.30 RTN4
 reticulon 4
 6297
 0.2
chr21_17584209_17584483 0.30 ENSG00000201025
 .
 72743
 0.13
chr19_11314227_11314401 0.29 CTC-510F12.2
10
 0.95
chr5_52098224_52098443 0.29 CTD-2288O8.1
14473
 0.19
chr10_63724125_63724283 0.29 ENSG00000221272
 .
 37427
 0.2
chr6_49293859_49294324 0.29 ENSG00000252457
 .
 18430
 0.26
chr4_77491396_77491547 0.28 ENSG00000263445
 .
 3250
 0.21
chr11_1930082_1930233 0.28 TNNT3
 troponin T type 3 (skeletal, fast)
 10635
 0.1
chr20_50180013_50180188 0.28 NFATC2
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
 730
 0.78
chr1_184476918_184477069 0.28 GS1-115G20.1
99522
 0.07
chr20_50417404_50418104 0.28 SALL4
 spalt-like transcription factor 4
 1193
 0.55
chr15_38547811_38548278 0.28 SPRED1
 sprouty-related, EVH1 domain containing 1
 2662
 0.42
chr5_36692416_36692567 0.28 CTD-2353F22.1
32784
 0.22
chr6_25179503_25179654 0.27 ENSG00000222373
 .
 13063
 0.19
chr7_143581670_143581927 0.27 FAM115A
 family with sequence similarity 115, member A
 665
 0.7
chr15_99864560_99864718 0.27 AC022819.2
 Uncharacterized protein
 4811
 0.23
chr9_80641416_80641906 0.27 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 3859
 0.36
chr2_198539715_198539970 0.26 RFTN2
 raftlin family member 2
 877
 0.6
chr5_88129679_88129830 0.26 MEF2C
 myocyte enhancer factor 2C
 6779
 0.28
chr13_42269392_42269543 0.26 ENSG00000241406
 .
 112346
 0.06
chr18_59249295_59249706 0.26 CDH20
 cadherin 20, type 2
 32401
 0.25
chr1_211306419_211307099 0.26 KCNH1-IT1
 KCNH1 intronic transcript 1 (non-protein coding)
 43
 0.92
chr20_62485470_62485890 0.26 ABHD16B
 abhydrolase domain containing 16B
 6886
 0.08
chr6_154800458_154800845 0.26 CNKSR3
 CNKSR family member 3
 1026
 0.69
chr3_46033980_46034131 0.26 FYCO1
 FYVE and coiled-coil domain containing 1
 3252
 0.24
chr10_16870751_16871209 0.26 RSU1
 Ras suppressor protein 1
 11453
 0.28
chr4_54230912_54231063 0.26 SCFD2
 sec1 family domain containing 2
 1241
 0.52
chr16_31022230_31022574 0.26 STX1B
 syntaxin 1B
 453
 0.64
chr20_11871763_11872529 0.26 BTBD3
 BTB (POZ) domain containing 3
 171
 0.97
chr15_36793558_36793709 0.25 C15orf41
 chromosome 15 open reading frame 41
 78179
 0.12
chr19_37096291_37096844 0.25 ZNF382
 zinc finger protein 382
 330
 0.52
chr1_8713025_8713176 0.25 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 3330
 0.34
chr17_36571464_36571657 0.25 ENSG00000266103
 .
 5518
 0.17
chr2_164589458_164589609 0.25 FIGN
 fidgetin
 2984
 0.42
chr5_148796790_148796941 0.25 ENSG00000208035
 .
 11616
 0.13
chr8_81934177_81934401 0.25 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 90014
 0.09
chr13_45242299_45242450 0.25 ENSG00000238932
 .
 39565
 0.2
chr4_186488570_186488721 0.24 RP11-301L8.2
20418
 0.16
chr5_141826116_141826340 0.24 AC005592.2
42445
 0.18
chr2_25017882_25018033 0.24 CENPO
 centromere protein O
 1624
 0.28
chr13_45059417_45059568 0.24 TSC22D1
 TSC22 domain family, member 1
 11106
 0.29
chr2_25599883_25600214 0.23 DNMT3A
 DNA (cytosine-5-)-methyltransferase 3 alpha
 34589
 0.16
chr2_192111446_192111930 0.23 MYO1B
 myosin IB
 679
 0.79
chr7_16751263_16751414 0.23 AC073333.8
8185
 0.18
chr11_12714851_12715219 0.23 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 17985
 0.26
chr6_152784305_152784456 0.23 SYNE1
 spectrin repeat containing, nuclear envelope 1
 9385
 0.22
chr1_217308938_217309289 0.23 ESRRG
 estrogen-related receptor gamma
 1983
 0.51
chr2_201021102_201021310 0.23 SPATS2L
 spermatogenesis associated, serine-rich 2-like
 149398
 0.04
chr3_52741792_52741943 0.23 SPCS1
 signal peptidase complex subunit 1 homolog (S. cerevisiae)
 1773
 0.15
chr6_72205767_72206133 0.22 ENSG00000212099
 .
 42729
 0.17
chr9_100264063_100264279 0.22 TMOD1
 tropomodulin 1
 250
 0.92
chr10_56993124_56993275 0.22 PCDH15
 protocadherin-related 15
 86175
 0.11
chr14_76327643_76327914 0.22 RP11-270M14.4
13737
 0.25
chr7_132737872_132738088 0.22 CHCHD3
 coiled-coil-helix-coiled-coil-helix domain containing 3
 28820
 0.2
chr3_24527242_24527393 0.22 ENSG00000228791
 .
 8261
 0.19
chr14_56047342_56047590 0.22 KTN1
 kinectin 1 (kinesin receptor)
 424
 0.62
chr5_111071431_111071582 0.21 STARD4-AS1
 STARD4 antisense RNA 1
 5420
 0.22
chr4_14864468_14865022 0.21 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 139553
 0.05
chr2_109257559_109258085 0.21 LIMS1
 LIM and senescent cell antigen-like domains 1
 13446
 0.22
chr4_141347804_141348226 0.21 CLGN
 calmegin
 529
 0.78
chr19_17790996_17791451 0.21 UNC13A
 unc-13 homolog A (C. elegans)
 4245
 0.17
chr15_31528566_31528785 0.21 TRPM1
 transient receptor potential cation channel, subfamily M, member 1
 75199
 0.1
chr5_82372177_82372328 0.21 TMEM167A
 transmembrane protein 167A
 1063
 0.38
chr9_124320076_124320249 0.21 DAB2IP
 DAB2 interacting protein
 9174
 0.18
chr11_113649028_113649338 0.21 CLDN25
 claudin 25
 1286
 0.35
chr10_62335914_62336175 0.21 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 3623
 0.38
chr13_23489541_23489915 0.20 ENSG00000240341
 .
 36390
 0.2
chr9_5518324_5518475 0.20 PDCD1LG2
 programmed cell death 1 ligand 2
 7829
 0.25
chr1_145524889_145525225 0.20 ITGA10
 integrin, alpha 10
 22
 0.95
chr4_114897314_114897610 0.20 ARSJ
 arylsulfatase family, member J
 2690
 0.37
chr14_92864159_92864342 0.20 SLC24A4
 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
 10473
 0.28
chr19_45931964_45932396 0.20 ERCC1
 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
 288
 0.84
chr2_3286362_3286843 0.20 TSSC1-IT1
 TSSC1 intronic transcript 1 (non-protein coding)
 18634
 0.24
chr10_33251129_33251359 0.20 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 967
 0.68
chr21_32707517_32707668 0.20 TIAM1
 T-cell lymphoma invasion and metastasis 1
 9002
 0.31
chr8_49014264_49014415 0.20 UBE2V2
 ubiquitin-conjugating enzyme E2 variant 2
 60032
 0.14
chr15_70994869_70995020 0.20 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 297
 0.94
chr7_18545603_18545779 0.20 HDAC9
 histone deacetylase 9
 3205
 0.37
chr1_31459830_31459981 0.20 PUM1
 pumilio RNA-binding family member 1
 8001
 0.17
chr21_17386302_17386519 0.20 ENSG00000252273
 .
 21419
 0.28
chr1_21348527_21348859 0.20 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 28702
 0.19
chr18_32290997_32291170 0.20 DTNA
 dystrobrevin, alpha
 822
 0.73
chr11_124595320_124595471 0.19 NRGN
 neurogranin (protein kinase C substrate, RC3)
 14347
 0.1
chr9_124360553_124361088 0.19 RP11-524G24.2
22327
 0.18
chr1_39882885_39883036 0.19 MACF1
 microtubule-actin crosslinking factor 1
 2888
 0.25
chr1_225879081_225879232 0.19 RP11-145A3.1
9150
 0.18
chr5_154138190_154138341 0.19 LARP1
 La ribonucleoprotein domain family, member 1
 1531
 0.39
chr7_50889730_50889881 0.19 GRB10
 growth factor receptor-bound protein 10
 28646
 0.21
chr5_167831410_167831561 0.19 WWC1
 WW and C2 domain containing 1
 1799
 0.45
chr2_44742897_44743048 0.19 CAMKMT
 calmodulin-lysine N-methyltransferase
 143091
 0.04
chrX_39504439_39504590 0.19 ENSG00000263730
 .
 15956
 0.29
chr4_86853777_86853998 0.19 ARHGAP24
 Rho GTPase activating protein 24
 2461
 0.32
chr16_3999501_3999652 0.19 RP11-462G12.1
869
 0.56
chr15_68406642_68406961 0.19 PIAS1
 protein inhibitor of activated STAT, 1
 59887
 0.12
chr9_97781118_97781407 0.19 C9orf3
 chromosome 9 open reading frame 3
 13984
 0.18
chr13_51252397_51252695 0.19 DLEU7-AS1
 DLEU7 antisense RNA 1
 129446
 0.05
chr12_25486836_25487071 0.19 ENSG00000201439
 .
 70409
 0.1
chr13_24901797_24901969 0.19 C1QTNF9-AS1
 C1QTNF9 antisense RNA 1
 6147
 0.17
chr2_145780897_145781240 0.19 ENSG00000253036
 .
 311570
 0.01
chr13_91032921_91033108 0.19 ENSG00000207858
 .
 149578
 0.05
chr5_76012905_76013056 0.19 CTD-2384B11.2
940
 0.39
chr2_196978205_196978455 0.19 RP11-347P5.1
37657
 0.15
chr7_18810006_18810178 0.19 ENSG00000222164
 .
 37810
 0.22
chr8_128902590_128902741 0.19 TMEM75
 transmembrane protein 75
 57926
 0.12
chr12_1697602_1697753 0.19 FBXL14
 F-box and leucine-rich repeat protein 14
 5654
 0.22
chr16_56658952_56660008 0.19 MT1E
 metallothionein 1E
 93
 0.91
chr20_56283633_56283861 0.19 PMEPA1
 prostate transmembrane protein, androgen induced 1
 1069
 0.63
chr10_3087908_3088170 0.19 PFKP
 phosphofructokinase, platelet
 20486
 0.26
chr6_121869662_121869813 0.18 ENSG00000201379
 .
 5965
 0.25
chrX_43831538_43831824 0.18 NDP
 Norrie disease (pseudoglioma)
 1069
 0.61
chr7_137439335_137439486 0.18 DGKI
 diacylglycerol kinase, iota
 91872
 0.09
chr7_36168506_36168695 0.18 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 24158
 0.18
chr5_6722325_6722630 0.18 PAPD7
 PAP associated domain containing 7
 7732
 0.28
chr14_85739826_85739977 0.18 ENSG00000252529
 .
 1625
 0.56
chr7_4763069_4763220 0.18 FOXK1
 forkhead box K1
 17346
 0.17
chr11_33398887_33399038 0.18 ENSG00000223134
 .
 22951
 0.23
chr14_39735421_39735572 0.18 RP11-407N17.3
 cTAGE family member 5 isoform 4
 6
 0.81
chr9_106853866_106854017 0.18 SMC2
 structural maintenance of chromosomes 2
 2600
 0.44
chr8_105373378_105373573 0.18 DCSTAMP
 dendrocyte expressed seven transmembrane protein
 12706
 0.2
chr2_227835215_227835366 0.18 ENSG00000212391
 .
 1452
 0.52
chr21_46550403_46550801 0.18 ADARB1
 adenosine deaminase, RNA-specific, B1
 9787
 0.16
chr5_54776796_54776996 0.18 ENSG00000265135
 .
 27858
 0.18
chr12_59227648_59227799 0.18 RP11-362K2.2
 Protein LOC100506869
 33569
 0.19
chr2_174361615_174361790 0.18 CDCA7
 cell division cycle associated 7
 142102
 0.05
chr21_17909068_17909746 0.17 ENSG00000207638
 .
 2002
 0.33
chr3_178787181_178787457 0.17 ZMAT3
 zinc finger, matrin-type 3
 2035
 0.36
chr11_19599028_19599179 0.17 ENSG00000265210
 .
 2246
 0.31
chr8_96443387_96443671 0.17 C8orf37
 chromosome 8 open reading frame 37
 162100
 0.04
chr1_109401335_109401486 0.17 SPATA42
 spermatogenesis associated 42 (non-protein coding)
 1544
 0.29
chr8_38030618_38031135 0.17 BAG4
 BCL2-associated athanogene 4
 3230
 0.13
chr15_55652527_55652678 0.17 CCPG1
 cell cycle progression 1
 197
 0.93
chr2_18157972_18158481 0.17 ENSG00000212455
 .
 63773
 0.13
chr2_33682993_33683144 0.17 RASGRP3
 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
 45
 0.99
chr17_74736392_74736543 0.17 MFSD11
 major facilitator superfamily domain containing 11
 2314
 0.13
chr1_212841495_212841646 0.17 ENSG00000207491
 .
 24036
 0.13
chr8_32084910_32085127 0.17 NRG1-IT2
 NRG1 intronic transcript 2 (non-protein coding)
 6574
 0.22
chr10_94039164_94039387 0.17 ENSG00000199881
 .
 7268
 0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.3 GO:0071318 cellular response to ATP(GO:0071318)
0.1 0.5 GO:0001553 luteinization(GO:0001553)
0.1 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.2 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 0.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.2 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 0.2 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.5 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.0 GO:2000051 regulation of non-canonical Wnt signaling pathway(GO:2000050) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.3 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.2 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.2 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0045634 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0071688 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.1 GO:1904376 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.0 GO:0060068 vagina development(GO:0060068)
0.0 0.0 GO:2001279 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.1 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0051883 disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0 0.0 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.2 GO:0009147 pyrimidine nucleoside triphosphate metabolic process(GO:0009147)
0.0 0.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234) positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.0 GO:1903312 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.0 GO:0060900 optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0 0.2 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.0 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0008354 germ cell migration(GO:0008354)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.0 GO:0060536 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.0 GO:0032277 regulation of gonadotropin secretion(GO:0032276) negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.2 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.4 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.0 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.0 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.0 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.0 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation