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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MEF2D_MEF2A

Z-value: 1.20

Motif logo

Transcription factors associated with MEF2D_MEF2A

Gene Symbol	Gene ID	Gene Info
MEF2D Ensembl NCBI GeneCards UniProt	ENSG00000116604.13	MEF2D
MEF2A Ensembl NCBI GeneCards UniProt	ENSG00000068305.13	MEF2A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MEF2A	chr15_100027229_100027393	9941	0.204639	0.79	1.1e-02	Click!
MEF2A	chr15_99991178_99991413	26075	0.174136	-0.69	3.8e-02	Click!
MEF2A	chr15_100026519_100026720	9249	0.206838	0.66	5.1e-02	Click!
MEF2A	chr15_99982440_99982591	34855	0.151225	0.61	7.8e-02	Click!
MEF2A	chr15_100108821_100109055	2250	0.363158	0.59	9.3e-02	Click!
MEF2D	chr1_156466320_156466471	4134	0.143467	0.82	6.6e-03	Click!
MEF2D	chr1_156480380_156480531	9835	0.115540	0.71	3.3e-02	Click!
MEF2D	chr1_156458657_156458808	1659	0.256349	-0.56	1.1e-01	Click!
MEF2D	chr1_156466052_156466203	4402	0.140380	0.55	1.2e-01	Click!
MEF2D	chr1_156471272_156471435	733	0.543760	-0.54	1.3e-01	Click!

Activity of the MEF2D_MEF2A motif across conditions

Conditions sorted by the z-value of the MEF2D_MEF2A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_88081859_88082385	0.90	MEF2C	myocyte enhancer factor 2C	37483	0.19
chr3_112353843_112353994	0.83	CCDC80	coiled-coil domain containing 80	3026	0.32
chr3_66139685_66140118	0.72	SLC25A26	solute carrier family 25 (S-adenosylmethionine carrier), member 26	20616	0.25
chr7_120631344_120631706	0.67	CPED1	cadherin-like and PC-esterase domain containing 1	1849	0.35
chr16_86775280_86775446	0.63	FOXL1	forkhead box L1	163248	0.03
chr2_155312257_155312697	0.63	AC009227.2		1473	0.49
chr11_43597772_43598095	0.60	ENSG00000199077	.	5011	0.24
chr1_151173034_151173185	0.59	PIP5K1A	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	2058	0.17
chr5_39399204_39399669	0.51	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	4934	0.29
chr1_17945358_17945612	0.51	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	636	0.82
chr2_17699920_17700290	0.50	RAD51AP2	RAD51 associated protein 2	399	0.89
chr13_94996950_94997101	0.49	ENSG00000212057	.	120619	0.06
chr12_109219039_109219464	0.47	SSH1	slingshot protein phosphatase 1	811	0.57
chr17_13502555_13502706	0.45	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	2614	0.37
chr3_48597891_48598569	0.45	PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	332	0.77
chr1_234630809_234631231	0.45	TARBP1	TAR (HIV-1) RNA binding protein 1	16171	0.21
chr11_85429273_85429899	0.44	SYTL2	synaptotagmin-like 2	55	0.97
chr7_112124877_112125132	0.44	LSMEM1	leucine-rich single-pass membrane protein 1	3958	0.27
chr14_89769991_89770787	0.43	RP11-356K23.1		46240	0.14
chr3_99357829_99358140	0.43	COL8A1	collagen, type VIII, alpha 1	530	0.85
chr19_11305569_11305933	0.42	KANK2	KN motif and ankyrin repeat domains 2	117	0.94
chr1_170632786_170633084	0.42	PRRX1	paired related homeobox 1	112	0.98
chr1_157962818_157962980	0.41	KIRREL	kin of IRRE like (Drosophila)	164	0.96
chr17_57564845_57564996	0.41	ENSG00000200889	.	49940	0.12
chr16_88449218_88449497	0.41	ZNF469	zinc finger protein 469	44522	0.14
chr1_24373488_24373760	0.39	RP11-293P20.2		6299	0.15
chr9_130615735_130616098	0.38	ENG	endoglin	999	0.31
chr5_65750356_65750571	0.38	MAST4	microtubule associated serine/threonine kinase family member 4	141713	0.05
chr9_81322437_81322726	0.37	PSAT1	phosphoserine aminotransferase 1	410522	0.01
chr3_145968218_145968873	0.37	PLSCR4	phospholipid scramblase 4	109	0.98
chr10_134401745_134402170	0.37	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	19473	0.23
chr4_41362274_41362647	0.37	LIMCH1	LIM and calponin homology domains 1	188	0.96
chr2_55226424_55226816	0.37	RTN4	reticulon 4	10965	0.21
chr14_34145464_34145720	0.37	NPAS3	neuronal PAS domain protein 3	58855	0.17
chr20_32979012_32979163	0.36	ENSG00000201498	.	7016	0.16
chr6_121760422_121760623	0.36	GJA1	gap junction protein, alpha 1, 43kDa	3684	0.22
chr11_109842804_109842955	0.36	ZC3H12C	zinc finger CCCH-type containing 12C	121208	0.07
chr9_98639144_98639295	0.36	ERCC6L2	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	1236	0.48
chr1_229762768_229763169	0.35	URB2	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	987	0.42
chr1_224805949_224806359	0.35	CNIH3	cornichon family AMPA receptor auxiliary protein 3	2159	0.29
chr5_132385127_132385278	0.35	HSPA4	heat shock 70kDa protein 4	2452	0.27
chr13_45011783_45011934	0.35	TSC22D1	TSC22 domain family, member 1	877	0.72
chr6_46458168_46458592	0.34	RCAN2	regulator of calcineurin 2	719	0.62
chr2_85389562_85389713	0.34	TCF7L1-IT1	TCF7L1 intronic transcript 1 (non-protein coding)	23895	0.15
chr1_93818876_93819027	0.34	ENSG00000223745	.	7369	0.19
chr12_9268515_9268666	0.34	A2M	alpha-2-macroglobulin	163	0.95
chr5_15499822_15500142	0.34	FBXL7	F-box and leucine-rich repeat protein 7	323	0.94
chr21_30504177_30504355	0.33	MAP3K7CL	MAP3K7 C-terminal like	688	0.61
chr1_50575996_50576351	0.33	ELAVL4	ELAV like neuron-specific RNA binding protein 4	795	0.71
chrX_69700453_69700680	0.33	DLG3-AS1	DLG3 antisense RNA 1	24722	0.14
chr5_174673965_174674120	0.32	DRD1	dopamine receptor D1	197169	0.03
chr2_179728640_179728888	0.32	CCDC141	coiled-coil domain containing 141	20914	0.17
chr7_90085000_90085151	0.32	CDK14	cyclin-dependent kinase 14	10663	0.23
chr18_3579974_3580125	0.31	ENSG00000238445	.	7008	0.16
chr5_14146856_14147086	0.31	TRIO	trio Rho guanine nucleotide exchange factor	3142	0.4
chr4_55095719_55096018	0.31	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	142	0.98
chr2_97018640_97018821	0.31	NCAPH	non-SMC condensin I complex, subunit H	11488	0.15
chr2_71356365_71356651	0.31	MCEE	methylmalonyl CoA epimerase	836	0.37
chr3_137834054_137834699	0.31	DZIP1L	DAZ interacting zinc finger protein 1-like	75	0.97
chr2_197852125_197852688	0.31	ANKRD44	ankyrin repeat domain 44	12820	0.25
chr4_15011908_15012097	0.30	CPEB2	cytoplasmic polyadenylation element binding protein 2	6442	0.31
chr20_19991582_19991882	0.30	NAA20	N(alpha)-acetyltransferase 20, NatB catalytic subunit	6028	0.22
chr4_86747653_86747804	0.30	ARHGAP24	Rho GTPase activating protein 24	1170	0.61
chr2_55345979_55346130	0.30	RTN4	reticulon 4	6297	0.2
chr21_17584209_17584483	0.30	ENSG00000201025	.	72743	0.13
chr19_11314227_11314401	0.29	CTC-510F12.2		10	0.95
chr5_52098224_52098443	0.29	CTD-2288O8.1		14473	0.19
chr10_63724125_63724283	0.29	ENSG00000221272	.	37427	0.2
chr6_49293859_49294324	0.29	ENSG00000252457	.	18430	0.26
chr4_77491396_77491547	0.28	ENSG00000263445	.	3250	0.21
chr11_1930082_1930233	0.28	TNNT3	troponin T type 3 (skeletal, fast)	10635	0.1
chr20_50180013_50180188	0.28	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	730	0.78
chr1_184476918_184477069	0.28	GS1-115G20.1		99522	0.07
chr20_50417404_50418104	0.28	SALL4	spalt-like transcription factor 4	1193	0.55
chr15_38547811_38548278	0.28	SPRED1	sprouty-related, EVH1 domain containing 1	2662	0.42
chr5_36692416_36692567	0.28	CTD-2353F22.1		32784	0.22
chr6_25179503_25179654	0.27	ENSG00000222373	.	13063	0.19
chr7_143581670_143581927	0.27	FAM115A	family with sequence similarity 115, member A	665	0.7
chr15_99864560_99864718	0.27	AC022819.2	Uncharacterized protein	4811	0.23
chr9_80641416_80641906	0.27	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	3859	0.36
chr2_198539715_198539970	0.26	RFTN2	raftlin family member 2	877	0.6
chr5_88129679_88129830	0.26	MEF2C	myocyte enhancer factor 2C	6779	0.28
chr13_42269392_42269543	0.26	ENSG00000241406	.	112346	0.06
chr18_59249295_59249706	0.26	CDH20	cadherin 20, type 2	32401	0.25
chr1_211306419_211307099	0.26	KCNH1-IT1	KCNH1 intronic transcript 1 (non-protein coding)	43	0.92
chr20_62485470_62485890	0.26	ABHD16B	abhydrolase domain containing 16B	6886	0.08
chr6_154800458_154800845	0.26	CNKSR3	CNKSR family member 3	1026	0.69
chr3_46033980_46034131	0.26	FYCO1	FYVE and coiled-coil domain containing 1	3252	0.24
chr10_16870751_16871209	0.26	RSU1	Ras suppressor protein 1	11453	0.28
chr4_54230912_54231063	0.26	SCFD2	sec1 family domain containing 2	1241	0.52
chr16_31022230_31022574	0.26	STX1B	syntaxin 1B	453	0.64
chr20_11871763_11872529	0.26	BTBD3	BTB (POZ) domain containing 3	171	0.97
chr15_36793558_36793709	0.25	C15orf41	chromosome 15 open reading frame 41	78179	0.12
chr19_37096291_37096844	0.25	ZNF382	zinc finger protein 382	330	0.52
chr1_8713025_8713176	0.25	RERE	arginine-glutamic acid dipeptide (RE) repeats	3330	0.34
chr17_36571464_36571657	0.25	ENSG00000266103	.	5518	0.17
chr2_164589458_164589609	0.25	FIGN	fidgetin	2984	0.42
chr5_148796790_148796941	0.25	ENSG00000208035	.	11616	0.13
chr8_81934177_81934401	0.25	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	90014	0.09
chr13_45242299_45242450	0.25	ENSG00000238932	.	39565	0.2
chr4_186488570_186488721	0.24	RP11-301L8.2		20418	0.16
chr5_141826116_141826340	0.24	AC005592.2		42445	0.18
chr2_25017882_25018033	0.24	CENPO	centromere protein O	1624	0.28
chr13_45059417_45059568	0.24	TSC22D1	TSC22 domain family, member 1	11106	0.29
chr2_25599883_25600214	0.23	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	34589	0.16
chr2_192111446_192111930	0.23	MYO1B	myosin IB	679	0.79
chr7_16751263_16751414	0.23	AC073333.8		8185	0.18
chr11_12714851_12715219	0.23	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	17985	0.26
chr6_152784305_152784456	0.23	SYNE1	spectrin repeat containing, nuclear envelope 1	9385	0.22
chr1_217308938_217309289	0.23	ESRRG	estrogen-related receptor gamma	1983	0.51
chr2_201021102_201021310	0.23	SPATS2L	spermatogenesis associated, serine-rich 2-like	149398	0.04
chr3_52741792_52741943	0.23	SPCS1	signal peptidase complex subunit 1 homolog (S. cerevisiae)	1773	0.15
chr6_72205767_72206133	0.22	ENSG00000212099	.	42729	0.17
chr9_100264063_100264279	0.22	TMOD1	tropomodulin 1	250	0.92
chr10_56993124_56993275	0.22	PCDH15	protocadherin-related 15	86175	0.11
chr14_76327643_76327914	0.22	RP11-270M14.4		13737	0.25
chr7_132737872_132738088	0.22	CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	28820	0.2
chr3_24527242_24527393	0.22	ENSG00000228791	.	8261	0.19
chr14_56047342_56047590	0.22	KTN1	kinectin 1 (kinesin receptor)	424	0.62
chr5_111071431_111071582	0.21	STARD4-AS1	STARD4 antisense RNA 1	5420	0.22
chr4_14864468_14865022	0.21	CPEB2	cytoplasmic polyadenylation element binding protein 2	139553	0.05
chr2_109257559_109258085	0.21	LIMS1	LIM and senescent cell antigen-like domains 1	13446	0.22
chr4_141347804_141348226	0.21	CLGN	calmegin	529	0.78
chr19_17790996_17791451	0.21	UNC13A	unc-13 homolog A (C. elegans)	4245	0.17
chr15_31528566_31528785	0.21	TRPM1	transient receptor potential cation channel, subfamily M, member 1	75199	0.1
chr5_82372177_82372328	0.21	TMEM167A	transmembrane protein 167A	1063	0.38
chr9_124320076_124320249	0.21	DAB2IP	DAB2 interacting protein	9174	0.18
chr11_113649028_113649338	0.21	CLDN25	claudin 25	1286	0.35
chr10_62335914_62336175	0.21	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	3623	0.38
chr13_23489541_23489915	0.20	ENSG00000240341	.	36390	0.2
chr9_5518324_5518475	0.20	PDCD1LG2	programmed cell death 1 ligand 2	7829	0.25
chr1_145524889_145525225	0.20	ITGA10	integrin, alpha 10	22	0.95
chr4_114897314_114897610	0.20	ARSJ	arylsulfatase family, member J	2690	0.37
chr14_92864159_92864342	0.20	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	10473	0.28
chr19_45931964_45932396	0.20	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	288	0.84
chr2_3286362_3286843	0.20	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	18634	0.24
chr10_33251129_33251359	0.20	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	967	0.68
chr21_32707517_32707668	0.20	TIAM1	T-cell lymphoma invasion and metastasis 1	9002	0.31
chr8_49014264_49014415	0.20	UBE2V2	ubiquitin-conjugating enzyme E2 variant 2	60032	0.14
chr15_70994869_70995020	0.20	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	297	0.94
chr7_18545603_18545779	0.20	HDAC9	histone deacetylase 9	3205	0.37
chr1_31459830_31459981	0.20	PUM1	pumilio RNA-binding family member 1	8001	0.17
chr21_17386302_17386519	0.20	ENSG00000252273	.	21419	0.28
chr1_21348527_21348859	0.20	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	28702	0.19
chr18_32290997_32291170	0.20	DTNA	dystrobrevin, alpha	822	0.73
chr11_124595320_124595471	0.19	NRGN	neurogranin (protein kinase C substrate, RC3)	14347	0.1
chr9_124360553_124361088	0.19	RP11-524G24.2		22327	0.18
chr1_39882885_39883036	0.19	MACF1	microtubule-actin crosslinking factor 1	2888	0.25
chr1_225879081_225879232	0.19	RP11-145A3.1		9150	0.18
chr5_154138190_154138341	0.19	LARP1	La ribonucleoprotein domain family, member 1	1531	0.39
chr7_50889730_50889881	0.19	GRB10	growth factor receptor-bound protein 10	28646	0.21
chr5_167831410_167831561	0.19	WWC1	WW and C2 domain containing 1	1799	0.45
chr2_44742897_44743048	0.19	CAMKMT	calmodulin-lysine N-methyltransferase	143091	0.04
chrX_39504439_39504590	0.19	ENSG00000263730	.	15956	0.29
chr4_86853777_86853998	0.19	ARHGAP24	Rho GTPase activating protein 24	2461	0.32
chr16_3999501_3999652	0.19	RP11-462G12.1		869	0.56
chr15_68406642_68406961	0.19	PIAS1	protein inhibitor of activated STAT, 1	59887	0.12
chr9_97781118_97781407	0.19	C9orf3	chromosome 9 open reading frame 3	13984	0.18
chr13_51252397_51252695	0.19	DLEU7-AS1	DLEU7 antisense RNA 1	129446	0.05
chr12_25486836_25487071	0.19	ENSG00000201439	.	70409	0.1
chr13_24901797_24901969	0.19	C1QTNF9-AS1	C1QTNF9 antisense RNA 1	6147	0.17
chr2_145780897_145781240	0.19	ENSG00000253036	.	311570	0.01
chr13_91032921_91033108	0.19	ENSG00000207858	.	149578	0.05
chr5_76012905_76013056	0.19	CTD-2384B11.2		940	0.39
chr2_196978205_196978455	0.19	RP11-347P5.1		37657	0.15
chr7_18810006_18810178	0.19	ENSG00000222164	.	37810	0.22
chr8_128902590_128902741	0.19	TMEM75	transmembrane protein 75	57926	0.12
chr12_1697602_1697753	0.19	FBXL14	F-box and leucine-rich repeat protein 14	5654	0.22
chr16_56658952_56660008	0.19	MT1E	metallothionein 1E	93	0.91
chr20_56283633_56283861	0.19	PMEPA1	prostate transmembrane protein, androgen induced 1	1069	0.63
chr10_3087908_3088170	0.19	PFKP	phosphofructokinase, platelet	20486	0.26
chr6_121869662_121869813	0.18	ENSG00000201379	.	5965	0.25
chrX_43831538_43831824	0.18	NDP	Norrie disease (pseudoglioma)	1069	0.61
chr7_137439335_137439486	0.18	DGKI	diacylglycerol kinase, iota	91872	0.09
chr7_36168506_36168695	0.18	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	24158	0.18
chr5_6722325_6722630	0.18	PAPD7	PAP associated domain containing 7	7732	0.28
chr14_85739826_85739977	0.18	ENSG00000252529	.	1625	0.56
chr7_4763069_4763220	0.18	FOXK1	forkhead box K1	17346	0.17
chr11_33398887_33399038	0.18	ENSG00000223134	.	22951	0.23
chr14_39735421_39735572	0.18	RP11-407N17.3	cTAGE family member 5 isoform 4	6	0.81
chr9_106853866_106854017	0.18	SMC2	structural maintenance of chromosomes 2	2600	0.44
chr8_105373378_105373573	0.18	DCSTAMP	dendrocyte expressed seven transmembrane protein	12706	0.2
chr2_227835215_227835366	0.18	ENSG00000212391	.	1452	0.52
chr21_46550403_46550801	0.18	ADARB1	adenosine deaminase, RNA-specific, B1	9787	0.16
chr5_54776796_54776996	0.18	ENSG00000265135	.	27858	0.18
chr12_59227648_59227799	0.18	RP11-362K2.2	Protein LOC100506869	33569	0.19
chr2_174361615_174361790	0.18	CDCA7	cell division cycle associated 7	142102	0.05
chr21_17909068_17909746	0.17	ENSG00000207638	.	2002	0.33
chr3_178787181_178787457	0.17	ZMAT3	zinc finger, matrin-type 3	2035	0.36
chr11_19599028_19599179	0.17	ENSG00000265210	.	2246	0.31
chr8_96443387_96443671	0.17	C8orf37	chromosome 8 open reading frame 37	162100	0.04
chr1_109401335_109401486	0.17	SPATA42	spermatogenesis associated 42 (non-protein coding)	1544	0.29
chr8_38030618_38031135	0.17	BAG4	BCL2-associated athanogene 4	3230	0.13
chr15_55652527_55652678	0.17	CCPG1	cell cycle progression 1	197	0.93
chr2_18157972_18158481	0.17	ENSG00000212455	.	63773	0.13
chr2_33682993_33683144	0.17	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	45	0.99
chr17_74736392_74736543	0.17	MFSD11	major facilitator superfamily domain containing 11	2314	0.13
chr1_212841495_212841646	0.17	ENSG00000207491	.	24036	0.13
chr8_32084910_32085127	0.17	NRG1-IT2	NRG1 intronic transcript 2 (non-protein coding)	6574	0.22
chr10_94039164_94039387	0.17	ENSG00000199881	.	7268	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	0.3	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	0.3	GO:0071318	cellular response to ATP(GO:0071318)
0.1	0.5	GO:0001553	luteinization(GO:0001553)
0.1	0.2	GO:0051182	coenzyme transport(GO:0051182)
0.1	0.2	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1	0.1	GO:0061298	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1	0.2	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1	0.2	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0010107	potassium ion import(GO:0010107)
0.0	0.2	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.5	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:2000051	regulation of non-canonical Wnt signaling pathway(GO:2000050) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0	0.3	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.2	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.6	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.7	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.2	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.2	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0071688	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0060068	vagina development(GO:0060068)
0.0	0.0	GO:2001279	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.2	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0051883	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.2	GO:0009147	pyrimidine nucleoside triphosphate metabolic process(GO:0009147)
0.0	0.0	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.1	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234) positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0060900	optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0	0.2	GO:0015936	coenzyme A metabolic process(GO:0015936)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.0	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
0.0	0.0	GO:0060536	trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.0	GO:0032277	regulation of gonadotropin secretion(GO:0032276) negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.2	GO:0030239	myofibril assembly(GO:0030239)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.0	GO:0060267	positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	0.4	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.4	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0000109	nucleotide-excision repair complex(GO:0000109)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.5	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1	0.3	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	0.3	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.3	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.1	0.5	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.2	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.2	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.3	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.0	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.2	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0016453	C-acetyltransferase activity(GO:0016453)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.4	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.3	PID ALK1 PATHWAY	ALK1 signaling events
0.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.6	NABA COLLAGENS	Genes encoding collagen proteins
0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	PID VEGFR1 PATHWAY	VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.4	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.4	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.2	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation