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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MEIS3_TGIF2LX

Z-value: 0.96

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Transcription factors associated with MEIS3_TGIF2LX

Gene Symbol Gene ID Gene Info
MEIS3
ENSG00000105419.13 MEIS3
TGIF2LX
ENSG00000153779.8 TGIF2LX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
MEIS3chr19_47920152_479203032450.9105130.723.0e-02Click!
MEIS3chr19_47885629_47885780267050.1221030.675.0e-02Click!
MEIS3chr19_47894051_47894202182830.1405720.599.6e-02Click!
MEIS3chr19_47921712_479218975750.7150240.571.1e-01Click!
MEIS3chr19_47922582_47922733850.9652140.541.4e-01Click!

Activity of the MEIS3_TGIF2LX motif across conditions

Conditions sorted by the z-value of the MEIS3_TGIF2LX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_119597594_119597745 0.65 PVRL1
 poliovirus receptor-related 1 (herpesvirus entry mediator C)
 1594
 0.37
chr7_27191813_27192140 0.64 HOXA-AS3
 HOXA cluster antisense RNA 3
 2305
 0.1
chr2_65547750_65548155 0.61 SPRED2
 sprouty-related, EVH1 domain containing 2
 13955
 0.23
chr20_58512577_58512765 0.59 PPP1R3D
 protein phosphatase 1, regulatory subunit 3D
 2681
 0.21
chr3_132349108_132349259 0.58 UBA5
 ubiquitin-like modifier activating enzyme 5
 24107
 0.16
chr11_120110982_120111133 0.57 POU2F3
 POU class 2 homeobox 3
 154
 0.95
chr7_40611540_40611691 0.55 AC004988.1
25088
 0.27
chr20_48989399_48989550 0.50 ENSG00000244376
 .
 56546
 0.13
chr14_37570606_37570757 0.50 RP11-537P22.2
2913
 0.31
chr10_99442034_99442185 0.48 AVPI1
 arginine vasopressin-induced 1
 4971
 0.16
chr1_205462241_205462485 0.48 CDK18
 cyclin-dependent kinase 18
 11360
 0.17
chr4_181055224_181055668 0.47 NA
 NA
 > 106
 NA
chr16_85673169_85673320 0.47 GSE1
 Gse1 coiled-coil protein
 14794
 0.16
chr20_22384501_22385014 0.47 FOXA2
 forkhead box A2
 180344
 0.03
chr9_18689231_18689382 0.47 ENSG00000252960
 .
 38161
 0.2
chr6_86114788_86115158 0.46 NT5E
 5'-nucleotidase, ecto (CD73)
 44836
 0.19
chr3_16308473_16308624 0.46 OXNAD1
 oxidoreductase NAD-binding domain containing 1
 1575
 0.33
chr2_9441510_9441661 0.46 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 94691
 0.07
chr22_33725446_33725597 0.45 SC22CB-1D7.1
8670
 0.27
chr6_106961305_106961653 0.43 AIM1
 absent in melanoma 1
 1749
 0.38
chr17_62195939_62196108 0.43 ERN1
 endoplasmic reticulum to nucleus signaling 1
 11462
 0.16
chr12_53264228_53264379 0.43 KRT78
 keratin 78
 21427
 0.12
chr4_125065453_125065672 0.43 ANKRD50
 ankyrin repeat domain 50
 568325
 0.0
chr5_112824477_112824726 0.42 MCC
 mutated in colorectal cancers
 74
 0.97
chr1_159111648_159111897 0.42 AIM2
 absent in melanoma 2
 1474
 0.37
chr4_31171719_31171870 0.41 RP11-619J20.1
376202
 0.01
chr17_50235287_50235438 0.40 CA10
 carbonic anhydrase X
 61
 0.99
chr2_165696044_165696353 0.40 AC019181.2
1061
 0.42
chr2_166131422_166131573 0.40 SCN2A
 sodium channel, voltage-gated, type II, alpha subunit
 19044
 0.25
chr5_2747693_2748131 0.39 IRX2
 iroquois homeobox 2
 3857
 0.28
chr4_2066511_2066662 0.38 NAT8L
 N-acetyltransferase 8-like (GCN5-related, putative)
 5047
 0.17
chr12_132915168_132915319 0.38 RP13-895J2.7
8807
 0.19
chr16_30078571_30078900 0.36 ALDOA
 aldolase A, fructose-bisphosphate
 89
 0.92
chr15_67311354_67311505 0.36 SMAD3
 SMAD family member 3
 44672
 0.19
chr20_10286915_10287750 0.35 ENSG00000211588
 .
 55546
 0.13
chr11_17411398_17411576 0.35 KCNJ11
 potassium inwardly-rectifying channel, subfamily J, member 11
 609
 0.69
chrX_7053368_7053519 0.35 ENSG00000264268
 .
 12458
 0.23
chr1_24706252_24706403 0.34 STPG1
 sperm-tail PG-rich repeat containing 1
 14
 0.98
chr1_177274527_177274678 0.34 ENSG00000222749
 .
 119014
 0.06
chr14_45559377_45559745 0.33 ENSG00000212615
 .
 2115
 0.2
chr22_30624979_30625130 0.33 RP1-102K2.6
10129
 0.11
chr1_209923190_209923341 0.33 TRAF3IP3
 TRAF3 interacting protein 3
 6112
 0.15
chr5_4258108_4258399 0.33 CTD-2012M11.3
657951
 0.0
chr8_28208694_28208845 0.32 ZNF395
 zinc finger protein 395
 314
 0.87
chr2_238804511_238804662 0.32 ENSG00000263723
 .
 26039
 0.17
chr10_36555876_36556027 0.32 ENSG00000237002
 .
 171638
 0.04
chr19_6239308_6239459 0.32 CTC-503J8.4
19785
 0.13
chr20_16514306_16514457 0.32 KIF16B
 kinesin family member 16B
 39697
 0.2
chr2_54557164_54557870 0.32 C2orf73
 chromosome 2 open reading frame 73
 346
 0.92
chr20_19915434_19915955 0.31 RIN2
 Ras and Rab interactor 2
 45484
 0.16
chr5_119723718_119723919 0.31 ENSG00000251975
 .
 50470
 0.18
chr3_58012091_58012242 0.31 FLNB
 filamin B, beta
 18039
 0.25
chr1_27928830_27929490 0.31 AHDC1
 AT hook, DNA binding motif, containing 1
 942
 0.51
chr3_126248153_126248304 0.31 CHST13
 carbohydrate (chondroitin 4) sulfotransferase 13
 5102
 0.16
chr19_42712082_42712233 0.31 DEDD2
 death effector domain containing 2
 9664
 0.09
chr7_29234619_29234840 0.30 CPVL
 carboxypeptidase, vitellogenic-like
 73
 0.64
chr7_35792332_35792483 0.30 SEPT7
 septin 7
 48135
 0.14
chr15_38543239_38543468 0.29 SPRED1
 sprouty-related, EVH1 domain containing 1
 1174
 0.65
chr19_31830357_31830584 0.29 AC007796.1
9317
 0.25
chr17_3814774_3814925 0.29 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
 4945
 0.17
chr2_46524867_46525365 0.29 EPAS1
 endothelial PAS domain protein 1
 575
 0.84
chr22_40078600_40078751 0.29 CACNA1I
 calcium channel, voltage-dependent, T type, alpha 1I subunit
 111917
 0.05
chr6_130010303_130010454 0.29 ARHGAP18
 Rho GTPase activating protein 18
 20992
 0.24
chr6_45751303_45751454 0.29 ENSG00000252738
 .
 137537
 0.05
chrX_281313_281835 0.29 LINC00685
 long intergenic non-protein coding RNA 685
 151
 0.97
chr7_113985866_113986017 0.29 FOXP2
 forkhead box P2
 68388
 0.12
chrX_42836312_42836609 0.29 MAOA
 monoamine oxidase A
 679007
 0.0
chr6_53659860_53660726 0.28 LRRC1
 leucine rich repeat containing 1
 405
 0.79
chr17_10703635_10703786 0.28 PIRT
 phosphoinositide-interacting regulator of transient receptor potential channels
 38052
 0.13
chr20_33585796_33585947 0.28 MYH7B
 myosin, heavy chain 7B, cardiac muscle, beta
 3177
 0.19
chr19_42636826_42637026 0.28 CTC-378H22.1
219
 0.52
chr16_70562877_70563028 0.28 ENSG00000221514
 .
 460
 0.7
chr13_80454610_80454761 0.28 NDFIP2
 Nedd4 family interacting protein 2
 399097
 0.01
chrX_22153788_22153939 0.28 PHEX-AS1
 PHEX antisense RNA 1
 37237
 0.17
chr1_19278015_19278216 0.27 IFFO2
 intermediate filament family orphan 2
 4077
 0.23
chr1_11619306_11619457 0.27 PTCHD2
 patched domain containing 2
 25648
 0.18
chr17_40274740_40274891 0.27 HSPB9
 heat shock protein, alpha-crystallin-related, B9
 59
 0.94
chr11_60939398_60939549 0.27 VPS37C
 vacuolar protein sorting 37 homolog C (S. cerevisiae)
 10384
 0.15
chr7_99474179_99474330 0.27 OR2AE1
 olfactory receptor, family 2, subfamily AE, member 1
 426
 0.76
chr1_13910795_13911459 0.27 PDPN
 podoplanin
 362
 0.87
chr7_104908860_104909472 0.27 SRPK2
 SRSF protein kinase 2
 296
 0.92
chr13_53765255_53765406 0.27 ENSG00000241613
 .
 66882
 0.14
chr8_99961674_99961862 0.26 OSR2
 odd-skipped related transciption factor 2
 1148
 0.46
chr6_157097564_157098248 0.26 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 1157
 0.47
chrY_231310_231809 0.26 NA
 NA
 > 106
 NA
chr12_618388_618539 0.26 B4GALNT3
 beta-1,4-N-acetyl-galactosaminyl transferase 3
 33836
 0.15
chr8_97602904_97603273 0.26 SDC2
 syndecan 2
 4473
 0.31
chr15_69868625_69868776 0.26 ENSG00000207119
 .
 118212
 0.05
chr8_83687250_83687401 0.26 SNX16
 sorting nexin 16
 932224
 0.0
chr1_185529229_185529380 0.26 ENSG00000207108
 .
 70356
 0.11
chr5_135347341_135347492 0.25 TGFBI
 transforming growth factor, beta-induced, 68kDa
 17168
 0.2
chr2_178032482_178032633 0.25 ENSG00000201102
 .
 27154
 0.12
chr6_1960344_1960495 0.25 GMDS
 GDP-mannose 4,6-dehydratase
 215806
 0.02
chr3_112964540_112964768 0.25 BOC
 BOC cell adhesion associated, oncogene regulated
 29456
 0.19
chr2_113593759_113594336 0.25 IL1B
 interleukin 1, beta
 36
 0.97
chr4_74485025_74485176 0.25 RASSF6
 Ras association (RalGDS/AF-6) domain family member 6
 1029
 0.65
chr19_4866504_4867667 0.25 PLIN3
 perilipin 3
 39
 0.96
chr4_77561140_77561386 0.25 AC107072.2
2487
 0.32
chr1_235132676_235132959 0.24 ENSG00000239690
 .
 92884
 0.08
chr18_9611313_9611464 0.24 PPP4R1
 protein phosphatase 4, regulatory subunit 1
 2897
 0.23
chr10_6101040_6101191 0.24 IL2RA
 interleukin 2 receptor, alpha
 3138
 0.2
chrX_71288852_71289006 0.24 RGAG4
 retrotransposon gag domain containing 4
 62749
 0.1
chr12_131199797_131200212 0.24 RIMBP2
 RIMS binding protein 2
 822
 0.73
chr6_91424436_91424686 0.24 MAP3K7
 mitogen-activated protein kinase kinase kinase 7
 127797
 0.06
chr11_128142089_128142381 0.24 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 233054
 0.02
chr2_113875856_113876007 0.24 IL1RN
 interleukin 1 receptor antagonist
 457
 0.77
chr6_128580481_128581088 0.24 PTPRK
 protein tyrosine phosphatase, receptor type, K
 62542
 0.14
chr1_37195790_37195941 0.24 RP4-614N24.1
42876
 0.19
chr18_18823015_18823269 0.24 GREB1L
 growth regulation by estrogen in breast cancer-like
 823
 0.71
chr12_106531293_106531501 0.24 NUAK1
 NUAK family, SNF1-like kinase, 1
 2414
 0.35
chr21_44614471_44614622 0.23 CRYAA
 crystallin, alpha A
 24280
 0.16
chr13_45008185_45008336 0.23 TSC22D1
 TSC22 domain family, member 1
 2721
 0.38
chr5_114505235_114505578 0.23 TRIM36
 tripartite motif containing 36
 200
 0.94
chr2_109934979_109935130 0.23 ENSG00000265965
 .
 4973
 0.34
chr2_236569141_236569292 0.23 AGAP1
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
 9032
 0.28
chr21_32537085_32537236 0.23 TIAM1
 T-cell lymphoma invasion and metastasis 1
 34621
 0.22
chr14_102050713_102051023 0.23 DIO3
 deiodinase, iodothyronine, type III
 23180
 0.17
chr6_44083954_44084715 0.23 TMEM63B
 transmembrane protein 63B
 10317
 0.15
chr20_6749993_6750220 0.23 BMP2
 bone morphogenetic protein 2
 1795
 0.51
chr8_63967849_63968000 0.23 GGH
 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
 16194
 0.18
chr12_95509986_95510137 0.23 FGD6
 FYVE, RhoGEF and PH domain containing 6
 688
 0.74
chr16_70749372_70749620 0.22 VAC14
 Vac14 homolog (S. cerevisiae)
 15348
 0.13
chr17_38178315_38178466 0.22 MED24
 mediator complex subunit 24
 1023
 0.38
chr3_113464275_113464538 0.22 NAA50
 N(alpha)-acetyltransferase 50, NatE catalytic subunit
 235
 0.9
chr17_3715887_3716038 0.22 C17orf85
 chromosome 17 open reading frame 85
 582
 0.7
chr1_185528978_185529129 0.22 ENSG00000207108
 .
 70607
 0.11
chr4_55650955_55651106 0.22 KIT
 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 126945
 0.06
chr12_25206187_25206540 0.22 LRMP
 lymphoid-restricted membrane protein
 689
 0.71
chr1_203648008_203648159 0.22 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
 3854
 0.27
chr20_31472115_31472266 0.22 EFCAB8
 EF-hand calcium binding domain 8
 25461
 0.15
chr16_51671642_51672070 0.22 ENSG00000223168
 .
 33618
 0.25
chr2_192709104_192709385 0.22 AC098617.1
2021
 0.33
chr4_29610349_29610500 0.22 ENSG00000252303
 .
 98167
 0.09
chr17_39821847_39822265 0.22 EIF1
 eukaryotic translation initiation factor 1
 23083
 0.09
chr22_27441616_27441767 0.22 ENSG00000200443
 .
 9841
 0.32
chr17_28552731_28552882 0.22 SLC6A4
 solute carrier family 6 (neurotransmitter transporter), member 4
 9910
 0.11
chr10_73532392_73533248 0.22 C10orf54
 chromosome 10 open reading frame 54
 435
 0.83
chr2_74220808_74220959 0.21 TET3
 tet methylcytosine dioxygenase 3
 8957
 0.16
chr4_145621271_145621422 0.21 HHIP-AS1
 HHIP antisense RNA 1
 38837
 0.19
chr19_18670319_18670560 0.21 KXD1
 KxDL motif containing 1
 517
 0.55
chr1_210465594_210466382 0.21 HHAT
 hedgehog acyltransferase
 35608
 0.17
chr9_34990286_34990475 0.21 DNAJB5
 DnaJ (Hsp40) homolog, subfamily B, member 5
 117
 0.95
chr3_99349930_99350081 0.21 COL8A1
 collagen, type VIII, alpha 1
 7314
 0.29
chr1_75811389_75811540 0.21 SLC44A5
 solute carrier family 44, member 5
 50857
 0.17
chr18_67712930_67713081 0.21 RTTN
 rotatin
 25051
 0.25
chr8_845837_845988 0.21 ERICH1-AS1
 ERICH1 antisense RNA 1
 12584
 0.3
chr3_30544040_30544191 0.21 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 103879
 0.08
chr7_76140575_76140726 0.21 UPK3B
 uroplakin 3B
 718
 0.6
chr16_89381066_89381217 0.21 AC137932.6
6400
 0.14
chr15_78112406_78112810 0.21 LINGO1
 leucine rich repeat and Ig domain containing 1
 66
 0.97
chr6_90119364_90119517 0.21 RRAGD
 Ras-related GTP binding D
 2349
 0.29
chr22_48027568_48027719 0.21 LL22NC03-75H12.2
 Novel protein; Uncharacterized protein
 144783
 0.05
chr19_39154900_39155424 0.21 ACTN4
 actinin, alpha 4
 16784
 0.11
chr3_10050371_10050522 0.21 EMC3
 ER membrane protein complex subunit 3
 2354
 0.15
chr9_110495286_110496024 0.20 AL162389.1
 Uncharacterized protein
 44764
 0.15
chr9_100870862_100871013 0.20 TRIM14
 tripartite motif containing 14
 10543
 0.19
chr2_57825783_57825934 0.20 ENSG00000212168
 .
 54188
 0.18
chr17_8368616_8368767 0.20 NDEL1
 nudE neurodevelopment protein 1-like 1
 14592
 0.14
chr1_39624513_39624771 0.20 ENSG00000222378
 .
 4674
 0.21
chr8_846023_846174 0.20 ERICH1-AS1
 ERICH1 antisense RNA 1
 12770
 0.3
chr5_36151340_36151953 0.20 LMBRD2
 LMBR1 domain containing 2
 417
 0.46
chr9_11751779_11751930 0.20 ENSG00000222581
 .
 548597
 0.0
chr12_104657438_104657589 0.20 RP11-818F20.5
16987
 0.18
chr20_62586715_62586914 0.20 UCKL1
 uridine-cytidine kinase 1-like 1
 954
 0.28
chr11_128773455_128773606 0.20 C11orf45
 chromosome 11 open reading frame 45
 2062
 0.28
chr4_184427310_184427800 0.20 ING2
 inhibitor of growth family, member 2
 195
 0.93
chr3_99363600_99363751 0.20 COL8A1
 collagen, type VIII, alpha 1
 6221
 0.28
chr7_148473091_148473297 0.20 ENSG00000251712
 .
 44910
 0.12
chr2_106886104_106886958 0.19 UXS1
 UDP-glucuronate decarboxylase 1
 75736
 0.1
chr22_45624284_45624435 0.19 KIAA0930
 KIAA0930
 1575
 0.36
chr8_96128376_96128527 0.19 PLEKHF2
 pleckstrin homology domain containing, family F (with FYVE domain) member 2
 17581
 0.16
chr2_60525179_60525372 0.19 ENSG00000200807
 .
 86465
 0.09
chrX_17342148_17342299 0.19 ENSG00000238764
 .
 33830
 0.19
chr12_110720958_110721647 0.19 ATP2A2
 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
 1816
 0.41
chr15_74873270_74873421 0.19 CLK3
 CDC-like kinase 3
 27368
 0.12
chr15_72529055_72529849 0.19 PKM
 pyruvate kinase, muscle
 5288
 0.17
chr11_13300075_13300637 0.19 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
 924
 0.7
chr19_2503722_2503936 0.19 ENSG00000252962
 .
 690
 0.64
chr12_123356373_123356852 0.19 HIP1R
 huntingtin interacting protein 1 related
 11900
 0.16
chr18_29028288_29028439 0.19 DSG3
 desmoglein 3
 605
 0.71
chr20_11137905_11138056 0.19 C20orf187
 chromosome 20 open reading frame 187
 129169
 0.06
chr6_27858007_27858288 0.19 HIST1H3J
 histone cluster 1, H3j
 423
 0.61
chr12_110440425_110440804 0.19 ANKRD13A
 ankyrin repeat domain 13A
 3286
 0.23
chr4_30725920_30726277 0.19 PCDH7
 protocadherin 7
 2121
 0.46
chr2_105320423_105320574 0.18 ENSG00000207249
 .
 29194
 0.21
chr5_54455785_54456014 0.18 GPX8
 glutathione peroxidase 8 (putative)
 47
 0.96
chr8_97864758_97864909 0.18 CPQ
 carboxypeptidase Q
 91365
 0.1
chr13_76079768_76079919 0.18 TBC1D4
 TBC1 domain family, member 4
 23593
 0.17
chr6_139433656_139433807 0.18 HECA
 headcase homolog (Drosophila)
 22518
 0.22
chr8_32412534_32412685 0.18 NRG1
 neuregulin 1
 6364
 0.32
chr5_139721787_139722024 0.18 HBEGF
 heparin-binding EGF-like growth factor
 4283
 0.14
chr15_62599631_62599782 0.18 RP11-299H22.5
36827
 0.17
chr2_175197056_175197207 0.18 SP9
 Sp9 transcription factor
 2543
 0.24
chr5_107285614_107285882 0.18 ENSG00000251732
 .
 139418
 0.05
chrX_128789131_128789414 0.18 APLN
 apelin
 339
 0.92
chr20_62670859_62671010 0.18 ZNF512B
 zinc finger protein 512B
 996
 0.34
chr15_68143074_68143225 0.18 ENSG00000206625
 .
 10766
 0.24
chr11_110166292_110166969 0.18 RDX
 radixin
 707
 0.81
chr4_185713844_185713995 0.18 ACSL1
 acyl-CoA synthetase long-chain family member 1
 13023
 0.18
chr11_36170786_36170937 0.18 ENSG00000263389
 .
 139213
 0.04

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of MEIS3_TGIF2LX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.2 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.2 GO:0010107 potassium ion import(GO:0010107)
0.1 0.2 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0003171 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.0 GO:2000696 nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0 0.1 GO:0003179 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.2 GO:0036303 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.1 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.2 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.3 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.5 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.1 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.0 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.1 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.1 GO:0031274 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.1 GO:0021873 forebrain neuroblast division(GO:0021873)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0010662 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0071501 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:2000095 regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.0 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.1 GO:0006837 serotonin transport(GO:0006837)
0.0 0.0 GO:1902305 regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0007619 courtship behavior(GO:0007619)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.0 GO:0060157 urinary bladder development(GO:0060157)
0.0 0.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.0 GO:2000189 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.0 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.0 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0002070 epithelial cell maturation(GO:0002070)
0.0 0.0 GO:0003283 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.0 GO:0043921 modulation by host of viral transcription(GO:0043921) modulation by host of symbiont transcription(GO:0052472)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.0 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.0 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.0 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.0 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.2 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.0 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.3 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0034648 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.0 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.0 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.0 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.0 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes