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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for MIXL1_GSX1_BSX_MEOX2_LHX4

Z-value: 1.07

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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4

Gene Symbol	Gene ID	Gene Info
MIXL1 Ensembl NCBI GeneCards UniProt	ENSG00000185155.7	Mix paired-like homeobox
GSX1 Ensembl NCBI GeneCards UniProt	ENSG00000169840.4	GS homeobox 1
BSX Ensembl NCBI GeneCards UniProt	ENSG00000188909.4	brain specific homeobox
MEOX2 Ensembl NCBI GeneCards UniProt	ENSG00000106511.5	mesenchyme homeobox 2
LHX4 Ensembl NCBI GeneCards UniProt	ENSG00000121454.4	LIM homeobox 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_122854763_122855057	BSX	2482	0.283447	-0.20	6.1e-01	Click!
chr11_122855667_122855916	BSX	3363	0.241757	0.17	6.7e-01	Click!
chr11_122855378_122855598	BSX	3060	0.252640	0.13	7.3e-01	Click!
chr11_122847569_122847720	BSX	4784	0.216183	0.13	7.4e-01	Click!
chr11_122855093_122855344	BSX	2790	0.265009	-0.06	8.8e-01	Click!
chr13_28365753_28365974	GSX1	917	0.630566	-0.91	7.5e-04	Click!
chr13_28363625_28363776	GSX1	3080	0.290233	-0.81	8.7e-03	Click!
chr13_28365022_28365726	GSX1	1406	0.472500	-0.77	1.6e-02	Click!
chr13_28364199_28364350	GSX1	2506	0.321935	-0.75	1.9e-02	Click!
chr13_28371323_28371474	GSX1	4618	0.243950	0.73	2.5e-02	Click!
chr1_180202492_180202643	LHX4	3146	0.279549	0.57	1.1e-01	Click!
chr1_180182634_180182785	LHX4	16712	0.193139	0.56	1.1e-01	Click!
chr1_180203614_180203822	LHX4	4297	0.248788	0.51	1.6e-01	Click!
chr1_180216351_180216502	LHX4	17005	0.195869	0.50	1.7e-01	Click!
chr1_180204707_180204858	LHX4	5361	0.234876	-0.44	2.4e-01	Click!
chr7_15791060_15791218	MEOX2	64702	0.136387	0.78	1.2e-02	Click!
chr7_15960889_15961040	MEOX2	234527	0.019950	0.74	2.4e-02	Click!
chr7_15790480_15790631	MEOX2	64118	0.137575	0.72	3.0e-02	Click!
chr7_15726278_15726429	MEOX2	84	0.980292	0.60	8.9e-02	Click!
chr7_15725909_15726109	MEOX2	428	0.881158	0.59	9.7e-02	Click!
chr1_226411658_226412041	MIXL1	530	0.782097	-0.51	1.6e-01	Click!
chr1_226412063_226412214	MIXL1	819	0.629574	0.20	6.0e-01	Click!
chr1_226411070_226411416	MIXL1	76	0.973162	-0.10	8.0e-01	Click!

Activity of the MIXL1_GSX1_BSX_MEOX2_LHX4 motif across conditions

Conditions sorted by the z-value of the MIXL1_GSX1_BSX_MEOX2_LHX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_78336292_78336638	1.96	NAV3	neuron navigator 3	23591	0.28
chr7_129933276_129933885	1.73	CPA4	carboxypeptidase A4	461	0.76
chr18_53089837_53090372	1.44	TCF4	transcription factor 4	361	0.89
chr4_77506894_77507309	1.41	ENSG00000265314	.	10397	0.17
chr8_37350646_37351319	1.24	RP11-150O12.6		23557	0.24
chr3_87036535_87037613	1.21	VGLL3	vestigial like 3 (Drosophila)	2778	0.42
chr21_17909068_17909746	1.20	ENSG00000207638	.	2002	0.33
chr20_46412966_46413363	1.19	SULF2	sulfatase 2	1069	0.59
chr11_131780111_131780399	1.14	NTM	neurotrimin	642	0.77
chr1_45083000_45083241	1.11	RNF220	ring finger protein 220	8878	0.17
chr5_1883178_1883404	1.10	IRX4	iroquois homeobox 4	411	0.66
chr1_68697735_68698156	1.09	WLS	wntless Wnt ligand secretion mediator	18	0.98
chr21_36254420_36254945	1.09	RUNX1	runt-related transcription factor 1	4798	0.34
chr9_18474095_18474958	1.08	ADAMTSL1	ADAMTS-like 1	295	0.95
chr1_87799796_87800719	1.05	LMO4	LIM domain only 4	2906	0.4
chr13_38172411_38172686	1.05	POSTN	periostin, osteoblast specific factor	315	0.95
chr3_33318777_33319866	1.05	FBXL2	F-box and leucine-rich repeat protein 2	353	0.91
chr5_147836900_147837051	1.05	CTD-2283N19.1		26605	0.18
chr1_179111271_179111703	1.05	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	692	0.72
chr20_50384318_50384901	1.04	ATP9A	ATPase, class II, type 9A	258	0.94
chr10_33622034_33622426	1.04	NRP1	neuropilin 1	1080	0.63
chr10_114714851_114715858	1.02	RP11-57H14.2		3720	0.26
chr4_141015619_141015856	1.01	RP11-392B6.1		33432	0.2
chr8_42063953_42065062	1.01	PLAT	plasminogen activator, tissue	576	0.71
chr2_207998546_207999225	1.00	KLF7	Kruppel-like factor 7 (ubiquitous)	24	0.98
chr12_56917781_56918152	1.00	RBMS2	RNA binding motif, single stranded interacting protein 2	2183	0.23
chr7_95107815_95108198	1.00	ASB4	ankyrin repeat and SOCS box containing 4	7207	0.2
chr4_124339424_124339730	0.99	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	18454	0.3
chr18_53090404_53090609	0.99	TCF4	transcription factor 4	763	0.7
chr3_150089259_150089633	0.96	TSC22D2	TSC22 domain family, member 2	36676	0.21
chr22_46462951_46463814	0.96	RP6-109B7.4		2389	0.16
chr17_33391542_33391948	0.94	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	874	0.45
chr4_153272766_153273041	0.94	FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	1220	0.52
chr17_79317268_79317735	0.94	TMEM105	transmembrane protein 105	13027	0.13
chr8_131206424_131206650	0.93	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	13429	0.23
chr6_116833589_116833880	0.93	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr11_106239153_106239583	0.93	RP11-680E19.1		104326	0.08
chr1_77464464_77464931	0.92	ENSG00000221720	.	8732	0.27
chr21_17442999_17443232	0.92	ENSG00000252273	.	35286	0.24
chr1_159111648_159111897	0.92	AIM2	absent in melanoma 2	1474	0.37
chr3_150131821_150132388	0.90	TSC22D2	TSC22 domain family, member 2	3308	0.35
chr7_17720120_17720505	0.88	SNX13	sorting nexin 13	259779	0.02
chr20_45754385_45754678	0.88	ENSG00000264901	.	41078	0.18
chr12_46949518_46949939	0.88	SLC38A2	solute carrier family 38, member 2	183078	0.03
chr4_61665381_61665532	0.88	ENSG00000265829	.	122881	0.06
chr5_3597777_3597928	0.88	IRX1	iroquois homeobox 1	1684	0.41
chr12_78334342_78334902	0.88	NAV3	neuron navigator 3	25434	0.27
chr6_157381110_157381404	0.87	RP1-137K2.2		59583	0.15
chr9_100069620_100070257	0.87	CCDC180	coiled-coil domain containing 180	3	0.98
chr2_55272861_55273322	0.86	RTN4	reticulon 4	931	0.61
chr3_126500993_126501380	0.86	CHCHD6	coiled-coil-helix-coiled-coil-helix domain containing 6	51779	0.16
chr2_161522670_161522919	0.86	RBMS1	RNA binding motif, single stranded interacting protein 1	172489	0.03
chr4_41215270_41215769	0.86	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	956	0.59
chr6_147528870_147529159	0.86	STXBP5	syntaxin binding protein 5 (tomosyn)	1904	0.39
chr1_225839301_225840394	0.85	ENAH	enabled homolog (Drosophila)	571	0.78
chr9_104248314_104249564	0.85	TMEM246	transmembrane protein 246	460	0.79
chr3_98700853_98701271	0.84	ENSG00000207331	.	73759	0.1
chr3_79216626_79216907	0.84	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	148157	0.05
chr7_98970111_98970529	0.83	ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	1552	0.28
chr12_76271592_76272084	0.83	ENSG00000243420	.	80072	0.1
chr15_101728252_101728749	0.83	CHSY1	chondroitin sulfate synthase 1	63637	0.1
chr6_19691587_19692480	0.81	ENSG00000200957	.	49273	0.18
chr1_214723042_214723197	0.81	PTPN14	protein tyrosine phosphatase, non-receptor type 14	1447	0.54
chr1_182992978_182993852	0.81	LAMC1	laminin, gamma 1 (formerly LAMB2)	820	0.64
chr10_24754741_24755189	0.80	KIAA1217	KIAA1217	495	0.84
chr1_233723927_233724223	0.80	KCNK1	potassium channel, subfamily K, member 1	25675	0.21
chr12_115135696_115136278	0.80	TBX3	T-box 3	14018	0.21
chr16_54961062_54961213	0.79	IRX5	iroquois homeobox 5	3637	0.38
chr3_134050593_134051228	0.78	AMOTL2	angiomotin like 2	39844	0.16
chr8_121137253_121137925	0.78	COL14A1	collagen, type XIV, alpha 1	237	0.96
chr5_92943123_92943644	0.77	ENSG00000251725	.	13111	0.2
chr12_50665639_50665877	0.77	LIMA1	LIM domain and actin binding 1	11509	0.13
chr8_127837007_127837644	0.77	ENSG00000212451	.	153558	0.04
chr9_79483882_79484033	0.77	PRUNE2	prune homolog 2 (Drosophila)	37044	0.21
chr15_88020923_88021173	0.77	ENSG00000207150	.	3528	0.4
chr18_21850703_21850950	0.77	OSBPL1A	oxysterol binding protein-like 1A	1370	0.35
chr4_157997366_157997978	0.77	GLRB	glycine receptor, beta	117	0.97
chr5_128796390_128797012	0.76	ADAMTS19-AS1	ADAMTS19 antisense RNA 1	319	0.77
chr5_82767889_82768074	0.76	VCAN	versican	237	0.96
chr11_24518160_24518510	0.76	LUZP2	leucine zipper protein 2	389	0.91
chr17_65427494_65427948	0.76	ENSG00000201547	.	22724	0.12
chr20_14315841_14316127	0.76	FLRT3	fibronectin leucine rich transmembrane protein 3	2270	0.36
chr9_22008020_22008450	0.75	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	717	0.61
chr9_110818837_110819103	0.75	ENSG00000222459	.	137711	0.05
chr15_71054590_71054766	0.75	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	1091	0.55
chr7_84267660_84267811	0.75	ENSG00000265050	.	27589	0.27
chrX_46652199_46652509	0.75	SLC9A7	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	33864	0.17
chr5_86416729_86416961	0.75	ENSG00000265919	.	6074	0.24
chr21_40357766_40357986	0.75	ENSG00000272015	.	91167	0.09
chr9_96819103_96819334	0.74	PTPDC1	protein tyrosine phosphatase domain containing 1	26142	0.21
chr10_13569370_13569685	0.74	RP11-214D15.2		989	0.36
chr10_12746098_12746480	0.74	ENSG00000221331	.	21063	0.25
chr13_40174017_40174396	0.73	LHFP	lipoma HMGIC fusion partner	3102	0.29
chr11_123178720_123179203	0.73	ENSG00000200496	.	6863	0.25
chr6_85823864_85824548	0.73	NT5E	5'-nucleotidase, ecto (CD73)	335603	0.01
chr1_198238845_198238996	0.73	NEK7	NIMA-related kinase 7	48991	0.19
chr4_14728626_14728777	0.73	ENSG00000202449	.	36367	0.24
chr6_167033822_167034287	0.73	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	6671	0.27
chr4_157692811_157693135	0.72	RP11-154F14.2		69538	0.11
chr1_196577911_196578299	0.72	KCNT2	potassium channel, subfamily T, member 2	250	0.94
chr20_14316163_14316462	0.72	FLRT3	fibronectin leucine rich transmembrane protein 3	1942	0.4
chr5_16916952_16917142	0.72	MYO10	myosin X	411	0.87
chr7_157140270_157140421	0.72	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	7830	0.25
chr9_40632604_40633916	0.71	SPATA31A3	SPATA31 subfamily A, member 3	67031	0.14
chr1_31480017_31480289	0.71	PUM1	pumilio RNA-binding family member 1	12202	0.19
chr15_96878465_96878729	0.71	ENSG00000222651	.	2107	0.24
chr6_139116835_139117557	0.71	ECT2L	epithelial cell transforming sequence 2 oncogene-like	61	0.98
chr3_93895824_93896204	0.71	ENSG00000253062	.	78604	0.1
chr15_96884556_96884898	0.71	ENSG00000222651	.	8237	0.16
chr11_27740250_27740471	0.70	BDNF	brain-derived neurotrophic factor	934	0.68
chr15_99788624_99789059	0.70	TTC23	tetratricopeptide repeat domain 23	895	0.51
chr7_134465735_134465936	0.70	CALD1	caldesmon 1	1406	0.57
chr1_9953446_9953936	0.70	CTNNBIP1	catenin, beta interacting protein 1	396	0.8
chr10_4285552_4285907	0.70	ENSG00000207124	.	271415	0.02
chr7_98029134_98029377	0.70	BAIAP2L1	BAI1-associated protein 2-like 1	1125	0.59
chr21_30517898_30518405	0.69	ENSG00000201984	.	6446	0.14
chr3_157822422_157822707	0.69	SHOX2	short stature homeobox 2	519	0.7
chr7_24988449_24988600	0.69	OSBPL3	oxysterol binding protein-like 3	30812	0.21
chr15_96881380_96881711	0.68	ENSG00000222651	.	5055	0.17
chr3_190530283_190530682	0.68	GMNC	geminin coiled-coil domain containing	49922	0.18
chr8_89311514_89311910	0.68	RP11-586K2.1		27353	0.2
chrX_114829080_114829277	0.68	PLS3	plastin 3	1313	0.48
chr10_69831641_69832005	0.67	HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	2071	0.33
chr12_66286178_66286489	0.67	RP11-366L20.2	Uncharacterized protein	10386	0.18
chr2_227590884_227591406	0.67	ENSG00000263363	.	67636	0.11
chr11_122029721_122030081	0.67	ENSG00000207994	.	6885	0.18
chr5_174178214_174178699	0.67	ENSG00000266890	.	281	0.94
chr8_87188438_87188625	0.67	CTD-3118D11.3		4116	0.24
chr21_36256046_36256553	0.67	RUNX1	runt-related transcription factor 1	3181	0.38
chr12_80081544_80081908	0.67	PAWR	PRKC, apoptosis, WT1, regulator	2134	0.41
chr1_102791433_102791584	0.67	OLFM3	olfactomedin 3	328922	0.01
chr4_134070427_134071051	0.66	PCDH10	protocadherin 10	269	0.96
chr17_45698884_45699286	0.66	NPEPPS	aminopeptidase puromycin sensitive	3369	0.19
chr9_4137636_4137913	0.66	GLIS3	GLIS family zinc finger 3	7419	0.28
chr2_3626466_3626991	0.66	ENSG00000252531	.	1432	0.27
chr15_96878987_96879612	0.66	ENSG00000222651	.	2809	0.21
chr5_73839186_73839374	0.66	HEXB	hexosaminidase B (beta polypeptide)	96568	0.07
chr8_93114852_93115389	0.66	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	334	0.94
chr11_121966638_121966789	0.66	ENSG00000207971	.	3839	0.19
chr3_71907377_71907649	0.66	ENSG00000239250	.	31185	0.2
chrX_86773476_86773748	0.65	KLHL4	kelch-like family member 4	795	0.74
chr5_131991447_131991948	0.65	AC004041.2		113	0.94
chr5_53753293_53753597	0.65	HSPB3	heat shock 27kDa protein 3	2000	0.44
chr15_37179413_37179956	0.65	ENSG00000212511	.	34843	0.22
chr16_4424352_4424847	0.65	VASN	vasorin	2750	0.17
chr4_170188382_170188561	0.65	SH3RF1	SH3 domain containing ring finger 1	2637	0.38
chr2_164591489_164591640	0.65	FIGN	fidgetin	953	0.74
chr9_43685829_43685980	0.64	CNTNAP3B	contactin associated protein-like 3B	994	0.67
chr7_107638965_107639116	0.64	ENSG00000238297	.	1387	0.38
chr20_59830411_59830643	0.64	CDH4	cadherin 4, type 1, R-cadherin (retinal)	3045	0.42
chr1_225842736_225843127	0.64	ENAH	enabled homolog (Drosophila)	2087	0.34
chr3_159483781_159484285	0.64	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr9_94065254_94065575	0.64	AUH	AU RNA binding protein/enoyl-CoA hydratase	58763	0.16
chr6_148829582_148830289	0.64	ENSG00000223322	.	15441	0.29
chr1_84107245_84107582	0.64	ENSG00000223231	.	152147	0.04
chr3_89074301_89074693	0.63	EPHA3	EPH receptor A3	82177	0.12
chr6_148663224_148663375	0.63	SASH1	SAM and SH3 domain containing 1	430	0.89
chr15_48436377_48436744	0.63	MYEF2	myelin expression factor 2	4963	0.17
chr8_57086542_57086822	0.63	PLAG1	pleiomorphic adenoma gene 1	37156	0.12
chr13_33787837_33788166	0.63	STARD13	StAR-related lipid transfer (START) domain containing 13	7858	0.24
chr18_33057581_33058355	0.63	INO80C	INO80 complex subunit C	9466	0.21
chr3_128207705_128209147	0.63	RP11-475N22.4		326	0.79
chr17_70113469_70114161	0.62	SOX9	SRY (sex determining region Y)-box 9	3346	0.37
chr3_191049544_191049695	0.62	UTS2B	urotensin 2B	1294	0.47
chr9_65576390_65577630	0.62	SPATA31A7	SPATA31 subfamily A, member 7	67400	0.15
chr1_28390431_28390759	0.62	EYA3	eyes absent homolog 3 (Drosophila)	5997	0.17
chr4_157891142_157892336	0.62	PDGFC	platelet derived growth factor C	316	0.91
chr5_122182822_122182973	0.62	SNX24	sorting nexin 24	1576	0.38
chr9_89952337_89952906	0.62	ENSG00000212421	.	77256	0.11
chr16_54968513_54968925	0.62	IRX5	iroquois homeobox 5	2735	0.43
chr16_54969464_54969709	0.62	IRX5	iroquois homeobox 5	3602	0.39
chr16_25345657_25345808	0.62	ZKSCAN2	zinc finger with KRAB and SCAN domains 2	76480	0.1
chr10_33798417_33798757	0.62	NRP1	neuropilin 1	173397	0.03
chr7_116312981_116313724	0.62	MET	met proto-oncogene	893	0.68
chr5_149867786_149868254	0.61	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	2163	0.3
chr3_79066759_79066910	0.61	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	860	0.75
chr2_24123591_24123937	0.61	ATAD2B	ATPase family, AAA domain containing 2B	26171	0.17
chr14_29859562_29859789	0.61	ENSG00000257522	.	11813	0.29
chr4_81191052_81191243	0.61	FGF5	fibroblast growth factor 5	3354	0.31
chr9_112813674_112813882	0.61	AKAP2	A kinase (PRKA) anchor protein 2	2802	0.39
chr1_215179099_215179440	0.61	KCNK2	potassium channel, subfamily K, member 2	71	0.99
chr13_30002091_30002575	0.60	MTUS2	microtubule associated tumor suppressor candidate 2	431	0.89
chr3_172035927_172036370	0.60	AC092964.1	Uncharacterized protein	1930	0.38
chr4_15685369_15685921	0.60	FAM200B	family with sequence similarity 200, member B	2216	0.26
chr8_32440879_32441165	0.60	NRG1	neuregulin 1	22144	0.27
chr8_12986347_12986498	0.60	DLC1	deleted in liver cancer 1	4561	0.27
chr18_20612011_20612377	0.60	ENSG00000223023	.	7635	0.17
chr6_106577764_106578076	0.60	RP1-134E15.3		29905	0.19
chr12_66222342_66222753	0.60	HMGA2	high mobility group AT-hook 2	3644	0.26
chr3_14212156_14212441	0.60	LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	7560	0.16
chr2_17801837_17802176	0.60	VSNL1	visinin-like 1	79579	0.1
chr11_15135960_15136328	0.60	INSC	inscuteable homolog (Drosophila)	340	0.92
chr4_183370400_183371073	0.59	TENM3	teneurin transmembrane protein 3	584	0.84
chr10_74854370_74854615	0.59	P4HA1	prolyl 4-hydroxylase, alpha polypeptide I	2116	0.19
chr4_114357002_114357251	0.59	ENSG00000206820	.	15647	0.2
chr9_89021021_89021390	0.59	ENSG00000222293	.	16838	0.24
chr4_95376265_95376416	0.59	PDLIM5	PDZ and LIM domain 5	56	0.99
chr22_36233928_36234199	0.59	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	2202	0.43
chr9_21677527_21678485	0.59	ENSG00000244230	.	21307	0.21
chr21_36253539_36254227	0.59	RUNX1	runt-related transcription factor 1	5597	0.33

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.7	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.7	2.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.7	2.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.4	1.6	GO:0060013	righting reflex(GO:0060013)
0.4	2.0	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.4	1.2	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.3	1.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.3	1.0	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.3	0.9	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3	0.9	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.3	1.8	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.3	0.9	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.3	0.8	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.3	1.1	GO:0043589	skin morphogenesis(GO:0043589)
0.3	0.3	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.3	0.3	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.3	0.8	GO:0016576	histone dephosphorylation(GO:0016576)
0.3	1.8	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.2	0.5	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.2	0.7	GO:0032808	lacrimal gland development(GO:0032808)
0.2	0.9	GO:0070141	response to UV-A(GO:0070141)
0.2	0.4	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.2	1.3	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.2	0.8	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.2	0.8	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.2	0.6	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.2	0.2	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.2	0.4	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.2	0.8	GO:0008218	bioluminescence(GO:0008218)
0.2	1.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.2	0.7	GO:0010659	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.2	0.4	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.2	0.5	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.2	0.2	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.2	0.5	GO:0060346	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.2	0.3	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.2	1.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.2	0.8	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.2	0.6	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2	0.2	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.2	0.5	GO:0021542	dentate gyrus development(GO:0021542)
0.1	0.3	GO:0072010	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1	0.3	GO:0060242	contact inhibition(GO:0060242)
0.1	0.3	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.9	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	0.1	GO:0060433	bronchus development(GO:0060433)
0.1	0.3	GO:0060435	bronchiole development(GO:0060435)
0.1	1.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.1	0.6	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.1	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.6	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.6	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	1.5	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.1	0.3	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.1	0.4	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.6	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.1	0.4	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1	0.5	GO:0010107	potassium ion import(GO:0010107)
0.1	1.5	GO:0035329	hippo signaling(GO:0035329)
0.1	0.2	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.1	0.2	GO:0051940	regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.5	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1	0.5	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.1	0.8	GO:0033327	Leydig cell differentiation(GO:0033327)
0.1	0.5	GO:0033197	response to vitamin E(GO:0033197)
0.1	0.2	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.1	0.4	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.1	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.1	0.2	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.5	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.1	1.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.1	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.4	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.3	GO:0010842	retina layer formation(GO:0010842)
0.1	0.1	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1	0.4	GO:0008354	germ cell migration(GO:0008354)
0.1	0.4	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.1	2.0	GO:0030199	collagen fibril organization(GO:0030199)
0.1	0.4	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.1	0.2	GO:0060677	ureteric bud elongation(GO:0060677)
0.1	0.4	GO:0048539	bone marrow development(GO:0048539)
0.1	0.5	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1	0.3	GO:0060174	limb bud formation(GO:0060174)
0.1	0.3	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.3	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1	0.3	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.1	0.3	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.1	1.7	GO:0008038	neuron recognition(GO:0008038)
0.1	0.3	GO:0042482	positive regulation of odontogenesis(GO:0042482)
0.1	0.3	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.1	0.3	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.1	2.1	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.1	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.1	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.3	GO:0032909	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.1	0.5	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.1	0.1	GO:0046015	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.1	0.2	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.6	GO:0008347	glial cell migration(GO:0008347)
0.1	0.1	GO:0031223	auditory behavior(GO:0031223)
0.1	0.2	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.1	0.3	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1	0.2	GO:0045655	regulation of monocyte differentiation(GO:0045655)
0.1	0.2	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	0.2	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.1	0.2	GO:0010159	specification of organ position(GO:0010159)
0.1	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.3	GO:0010042	response to manganese ion(GO:0010042)
0.1	0.2	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.2	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.1	0.2	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.1	0.2	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.1	1.5	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.1	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.1	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.1	0.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	0.2	GO:0051968	positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1	3.6	GO:0034332	adherens junction organization(GO:0034332)
0.1	0.6	GO:0002076	osteoblast development(GO:0002076)
0.1	0.4	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.1	1.1	GO:0042730	fibrinolysis(GO:0042730)
0.1	0.5	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1	0.3	GO:0034063	stress granule assembly(GO:0034063)
0.1	0.5	GO:0015871	choline transport(GO:0015871)
0.1	0.7	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.1	0.1	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.1	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.1	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.2	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.1	0.3	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.1	0.1	GO:0021521	ventral spinal cord interneuron specification(GO:0021521) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) cell fate specification involved in pattern specification(GO:0060573)
0.1	0.3	GO:0009415	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.1	0.5	GO:0001660	fever generation(GO:0001660)
0.1	0.2	GO:1903332	regulation of protein folding(GO:1903332)
0.1	0.6	GO:0099518	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.1	0.2	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.1	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1	1.0	GO:0021766	hippocampus development(GO:0021766)
0.1	1.2	GO:0051353	positive regulation of oxidoreductase activity(GO:0051353)
0.1	0.2	GO:0001945	lymph vessel development(GO:0001945)
0.1	0.2	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.1	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.1	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.1	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.1	0.1	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.1	0.3	GO:0016246	RNA interference(GO:0016246)
0.1	0.1	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.1	0.7	GO:0048538	thymus development(GO:0048538)
0.1	0.2	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.1	0.2	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.1	0.1	GO:1903579	negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.1	0.1	GO:0010454	negative regulation of cell fate commitment(GO:0010454)
0.1	0.1	GO:0042640	anagen(GO:0042640)
0.1	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.1	0.2	GO:0014850	response to muscle activity(GO:0014850)
0.1	0.1	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.1	0.5	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.5	GO:0060612	adipose tissue development(GO:0060612)
0.1	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.1	0.8	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.1	0.1	GO:0014911	positive regulation of smooth muscle cell migration(GO:0014911)
0.1	0.1	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.1	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.1	0.4	GO:0031000	response to caffeine(GO:0031000)
0.1	1.5	GO:0060606	tube closure(GO:0060606)
0.1	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.2	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.0	0.3	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.0	GO:0072162	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0051955	regulation of amino acid transport(GO:0051955)
0.0	0.2	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.2	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.2	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.2	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.0	0.2	GO:0055117	regulation of cardiac muscle contraction(GO:0055117)
0.0	0.4	GO:0008589	regulation of smoothened signaling pathway(GO:0008589)
0.0	0.1	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(GO:0035872) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.2	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.4	GO:0048566	embryonic digestive tract development(GO:0048566)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0010596	negative regulation of endothelial cell migration(GO:0010596)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.2	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.6	GO:0090263	positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.0	GO:0043618	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.0	0.4	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.7	GO:0030574	collagen catabolic process(GO:0030574)
0.0	1.0	GO:0046068	cGMP metabolic process(GO:0046068)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.2	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.8	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.2	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.6	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	4.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.1	GO:0035725	sodium ion transmembrane transport(GO:0035725)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.8	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.3	GO:0046697	decidualization(GO:0046697)
0.0	0.1	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.0	0.4	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0051930	regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0	0.2	GO:0032740	positive regulation of interleukin-17 production(GO:0032740)
0.0	0.2	GO:0050819	negative regulation of coagulation(GO:0050819)
0.0	0.3	GO:0042220	response to cocaine(GO:0042220)
0.0	0.0	GO:1902667	regulation of axon guidance(GO:1902667)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.2	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.2	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0090102	cochlea development(GO:0090102)
0.0	0.7	GO:0051925	obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0	0.3	GO:0007320	insemination(GO:0007320)
0.0	0.3	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.1	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.2	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.0	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.2	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.2	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.0	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.0	0.2	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0001885	endothelial cell development(GO:0001885)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.1	GO:0002118	aggressive behavior(GO:0002118)
0.0	0.1	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0022601	menstrual cycle phase(GO:0022601)
0.0	0.1	GO:0051043	regulation of membrane protein ectodomain proteolysis(GO:0051043)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	1.2	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	0.0	GO:0009111	vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0	0.0	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.4	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.1	GO:0035058	nonmotile primary cilium assembly(GO:0035058)
0.0	0.0	GO:0034380	high-density lipoprotein particle assembly(GO:0034380)
0.0	0.1	GO:0003151	outflow tract morphogenesis(GO:0003151)
0.0	0.7	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.1	GO:0001706	endoderm formation(GO:0001706)
0.0	0.1	GO:0042161	plasma lipoprotein particle oxidation(GO:0034441) regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.5	GO:0014047	glutamate secretion(GO:0014047)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.3	GO:0030901	midbrain development(GO:0030901)
0.0	0.2	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0032278	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.0	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.2	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0015811	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.2	GO:0008542	visual learning(GO:0008542)
0.0	0.2	GO:0046653	tetrahydrofolate metabolic process(GO:0046653)
0.0	0.0	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) ossification involved in bone maturation(GO:0043931)
0.0	0.2	GO:0006241	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0	0.0	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0032206	positive regulation of telomere maintenance(GO:0032206)
0.0	0.1	GO:0010896	regulation of triglyceride catabolic process(GO:0010896)
0.0	0.2	GO:0006622	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:1901984	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0032782	canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0	0.4	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.0	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.9	GO:0007219	Notch signaling pathway(GO:0007219)
0.0	0.0	GO:0021511	spinal cord patterning(GO:0021511)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:0046469	platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0031069	hair follicle morphogenesis(GO:0031069)
0.0	0.2	GO:0001756	somitogenesis(GO:0001756) somite development(GO:0061053)
0.0	0.3	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0	0.1	GO:0030539	male genitalia development(GO:0030539)
0.0	0.1	GO:0032099	negative regulation of appetite(GO:0032099)
0.0	0.1	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.0	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.0	GO:0002024	diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0	0.4	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	0.1	GO:0050884	neuromuscular process controlling posture(GO:0050884)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:2001234	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.0	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299) obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0010092	specification of organ identity(GO:0010092)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0044247	glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0014037	Schwann cell differentiation(GO:0014037)
0.0	0.0	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.0	GO:0007210	serotonin receptor signaling pathway(GO:0007210)
0.0	0.0	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0	0.0	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.0	0.0	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.0	GO:0072077	mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) mesenchymal to epithelial transition(GO:0060231) renal vesicle morphogenesis(GO:0072077) metanephric nephron morphogenesis(GO:0072273) metanephric renal vesicle morphogenesis(GO:0072283)
0.0	0.0	GO:0043084	penile erection(GO:0043084)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.2	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.0	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.0	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.2	GO:0042255	ribosome assembly(GO:0042255)
0.0	0.2	GO:0051923	sulfation(GO:0051923)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:2000344	positive regulation of acrosome reaction(GO:2000344)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.0	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0021889	olfactory bulb interneuron differentiation(GO:0021889)
0.0	0.0	GO:2000108	positive regulation of leukocyte apoptotic process(GO:2000108)
0.0	0.0	GO:0032276	regulation of gonadotropin secretion(GO:0032276)
0.0	0.0	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.0	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.2	GO:0007215	glutamate receptor signaling pathway(GO:0007215)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.0	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0	0.1	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
0.0	0.1	GO:0098869	removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0	0.0	GO:0060592	mammary gland formation(GO:0060592)
0.0	0.0	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.0	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.2	GO:0019233	sensory perception of pain(GO:0019233)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:0051026	chiasma assembly(GO:0051026)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0060395	SMAD protein signal transduction(GO:0060395)
0.0	0.0	GO:1902913	positive regulation of neuroepithelial cell differentiation(GO:1902913)
0.0	0.0	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.0	GO:0015732	prostaglandin transport(GO:0015732)
0.0	0.0	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0021904	dorsal/ventral neural tube patterning(GO:0021904)
0.0	0.0	GO:0060179	male courtship behavior(GO:0008049) male mating behavior(GO:0060179)
0.0	0.4	GO:0045444	fat cell differentiation(GO:0045444)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.0	GO:0032288	myelin assembly(GO:0032288)
0.0	0.0	GO:0032098	regulation of appetite(GO:0032098)
0.0	0.0	GO:0045844	positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0	0.9	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	0.1	GO:0042438	melanin biosynthetic process(GO:0042438)
0.0	0.2	GO:0018149	peptide cross-linking(GO:0018149)
0.0	0.1	GO:0042461	photoreceptor cell development(GO:0042461) eye photoreceptor cell development(GO:0042462)
0.0	0.0	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.0	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0007224	smoothened signaling pathway(GO:0007224)
0.0	0.0	GO:0007350	blastoderm segmentation(GO:0007350)
0.0	0.0	GO:0009125	nucleoside monophosphate catabolic process(GO:0009125)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0060674	placenta blood vessel development(GO:0060674)
0.0	0.0	GO:0060840	artery development(GO:0060840)
0.0	0.0	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0	0.0	GO:0019240	citrulline biosynthetic process(GO:0019240)
0.0	0.0	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.0	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.2	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.0	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.3	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	0.1	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.0	GO:0032226	positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0	0.0	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	1.2	GO:0006813	potassium ion transport(GO:0006813)
0.0	0.0	GO:0006590	thyroid hormone generation(GO:0006590)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0043259	laminin-10 complex(GO:0043259)
0.4	1.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.4	1.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3	1.8	GO:0005587	collagen type IV trimer(GO:0005587)
0.2	0.2	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.2	1.0	GO:0071437	invadopodium(GO:0071437)
0.2	0.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	1.5	GO:0005614	interstitial matrix(GO:0005614)
0.2	0.5	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	0.7	GO:0005915	zonula adherens(GO:0005915)
0.1	0.4	GO:0005588	collagen type V trimer(GO:0005588)
0.1	1.0	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.2	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.4	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.4	GO:0005606	laminin-1 complex(GO:0005606)
0.1	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	0.3	GO:0043256	laminin complex(GO:0043256)
0.1	0.8	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	0.7	GO:0030673	axolemma(GO:0030673)
0.1	0.6	GO:0005916	fascia adherens(GO:0005916)
0.1	0.5	GO:0031512	motile primary cilium(GO:0031512)
0.1	1.4	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	0.2	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.1	1.0	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1	0.6	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.4	GO:0001527	microfibril(GO:0001527)
0.1	0.2	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	0.2	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	0.3	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	4.0	GO:0030426	growth cone(GO:0030426)
0.1	0.1	GO:0033643	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	2.7	GO:0005604	basement membrane(GO:0005604)
0.1	1.0	GO:0045178	basal part of cell(GO:0045178)
0.1	0.4	GO:0010369	chromocenter(GO:0010369)
0.1	0.2	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	0.3	GO:0005581	collagen trimer(GO:0005581)
0.1	0.9	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.9	GO:0030057	desmosome(GO:0030057)
0.1	0.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	0.5	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.3	GO:0031941	filamentous actin(GO:0031941)
0.0	0.2	GO:0032059	bleb(GO:0032059)
0.0	9.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.3	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.2	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.2	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	2.6	GO:0030027	lamellipodium(GO:0030027)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	2.6	GO:0060076	excitatory synapse(GO:0060076)
0.0	1.1	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.1	GO:0070938	actomyosin contractile ring(GO:0005826) contractile ring(GO:0070938)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.7	GO:0030018	Z disc(GO:0030018)
0.0	1.4	GO:0016459	myosin complex(GO:0016459)
0.0	1.2	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.4	GO:0005811	lipid particle(GO:0005811)
0.0	1.9	GO:0034705	potassium channel complex(GO:0034705)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	1.0	GO:0043292	myofibril(GO:0030016) contractile fiber(GO:0043292)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	2.1	GO:0031225	anchored component of membrane(GO:0031225)
0.0	0.2	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.5	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	1.0	GO:0043296	apical junction complex(GO:0043296)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.1	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.0	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.3	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0030686	90S preribosome(GO:0030686)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.3	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	6.0	GO:0005615	extracellular space(GO:0005615)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	2.9	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.4	1.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.4	1.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.4	2.0	GO:0017154	semaphorin receptor activity(GO:0017154)
0.4	1.5	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.3	1.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.3	0.9	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.3	0.6	GO:0050682	AF-2 domain binding(GO:0050682)
0.3	1.7	GO:0008046	axon guidance receptor activity(GO:0008046)
0.3	1.7	GO:0005499	vitamin D binding(GO:0005499)
0.3	0.9	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.3	1.3	GO:0042805	actinin binding(GO:0042805)
0.3	2.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.2	0.7	GO:0003680	AT DNA binding(GO:0003680)
0.2	0.8	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.2	0.8	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2	0.6	GO:0016842	amidine-lyase activity(GO:0016842)
0.2	0.6	GO:0002162	dystroglycan binding(GO:0002162)
0.2	0.6	GO:0045545	syndecan binding(GO:0045545)
0.2	0.5	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.1	0.4	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.6	GO:0048495	Roundabout binding(GO:0048495)
0.1	1.0	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	0.7	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	0.1	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.1	1.3	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.1	1.7	GO:0043498	obsolete cell surface binding(GO:0043498)
0.1	0.7	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.1	1.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.6	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.1	0.4	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	1.4	GO:0004065	arylsulfatase activity(GO:0004065)
0.1	0.3	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.8	GO:0017166	vinculin binding(GO:0017166)
0.1	0.3	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.3	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	0.6	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.1	0.4	GO:0045499	chemorepellent activity(GO:0045499)
0.1	0.4	GO:0016361	activin receptor activity, type I(GO:0016361)
0.1	1.7	GO:0005109	frizzled binding(GO:0005109)
0.1	1.3	GO:0005523	tropomyosin binding(GO:0005523)
0.1	0.4	GO:0050897	cobalt ion binding(GO:0050897)
0.1	3.3	GO:0005518	collagen binding(GO:0005518)
0.1	0.5	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.1	0.3	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.3	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	0.9	GO:0051010	microtubule plus-end binding(GO:0051010)
0.1	0.3	GO:0032052	bile acid binding(GO:0032052)
0.1	1.2	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.1	0.2	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.4	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.1	0.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	0.5	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.1	0.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	0.3	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1	4.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	1.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.1	0.3	GO:0004470	malic enzyme activity(GO:0004470)
0.1	1.1	GO:0045296	cadherin binding(GO:0045296)
0.1	0.4	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.1	0.6	GO:0001968	fibronectin binding(GO:0001968)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.2	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	0.3	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	0.3	GO:0043522	leucine zipper domain binding(GO:0043522)
0.1	0.3	GO:0005534	galactose binding(GO:0005534)
0.1	0.8	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	1.0	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.2	GO:0019863	IgE binding(GO:0019863)
0.1	0.5	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1	1.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.2	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.1	0.4	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.1	0.6	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	0.2	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	0.5	GO:0005112	Notch binding(GO:0005112)
0.1	0.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1	0.3	GO:0044390	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.1	0.2	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.1	0.3	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.1	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.1	0.3	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.4	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.5	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.2	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	1.0	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.4	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.6	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.3	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.7	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.2	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.7	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.2	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.4	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.2	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.2	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.3	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.8	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	1.1	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.2	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	0.7	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.2	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.4	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.2	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.7	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.2	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.4	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.5	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.3	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.3	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.4	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.3	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.4	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.3	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.3	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	2.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.2	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.3	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.7	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0019798	procollagen-proline dioxygenase activity(GO:0019798)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.2	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.2	GO:0008175	tRNA methyltransferase activity(GO:0008175)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	1.1	GO:0008201	heparin binding(GO:0008201)
0.0	0.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.0	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	1.7	GO:0008083	growth factor activity(GO:0008083)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0009975	cyclase activity(GO:0009975)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	1.9	GO:0003774	motor activity(GO:0003774)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0016453	C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.3	GO:0030145	manganese ion binding(GO:0030145)
0.0	0.1	GO:0010851	cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:0043855	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0	0.3	GO:0070330	aromatase activity(GO:0070330)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0035254	glutamate receptor binding(GO:0035254)
0.0	0.0	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	3.4	GO:0030528	obsolete transcription regulator activity(GO:0030528)
0.0	0.0	GO:0019956	chemokine binding(GO:0019956)
0.0	0.6	GO:0051015	actin filament binding(GO:0051015)
0.0	6.1	GO:0005509	calcium ion binding(GO:0005509)
0.0	0.0	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.0	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.0	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.1	GO:0016411	acylglycerol O-acyltransferase activity(GO:0016411)
0.0	0.2	GO:0008527	taste receptor activity(GO:0008527)
0.0	0.7	GO:0022843	voltage-gated cation channel activity(GO:0022843)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.0	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.3	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	2.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	2.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	1.1	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	2.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	0.6	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	0.7	PID CDC42 PATHWAY	CDC42 signaling events
0.1	5.0	NABA COLLAGENS	Genes encoding collagen proteins
0.1	0.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	0.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	0.6	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	0.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	3.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	1.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	0.6	PID FGF PATHWAY	FGF signaling pathway
0.1	0.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	1.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	0.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	0.8	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	0.1	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	0.2	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	1.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	2.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	7.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.3	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.4	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.6	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	6.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.3	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	4.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.3	PID P73PATHWAY	p73 transcription factor network
0.0	0.3	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.0	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	4.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	0.5	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0	0.0	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.3	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.0	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.2	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	0.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.2	4.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	3.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	0.7	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	3.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	1.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	0.5	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	1.4	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	0.1	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.1	0.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	5.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	1.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	1.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.1	0.9	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	1.8	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.1	0.8	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	1.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	0.9	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	0.1	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.1	0.4	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	0.8	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	0.7	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	0.2	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.1	0.2	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	0.8	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	0.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	0.8	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	0.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	1.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.4	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.2	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	1.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.9	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.4	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.2	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.8	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.4	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.3	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.6	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.9	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	1.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.8	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.4	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.3	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	1.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.0	REACTOME M G1 TRANSITION	Genes involved in M/G1 Transition
0.0	0.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.0	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.0	0.1	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.6	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0	0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.3	REACTOME GABA B RECEPTOR ACTIVATION	Genes involved in GABA B receptor activation
0.0	0.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.2	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.4	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.0	0.2	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.6	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.0	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Results for MIXL1_GSX1_BSX_MEOX2_LHX4

Z-value: 1.07

Motif logo

Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the MIXL1_GSX1_BSX_MEOX2_LHX4 motif across conditions

Conditions sorted by the z-value of the MIXL1_GSX1_BSX_MEOX2_LHX4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: