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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MLXIPL

Z-value: 0.78

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Transcription factors associated with MLXIPL

Gene Symbol Gene ID Gene Info
MLXIPL
ENSG00000009950.11 MLXIPL

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
MLXIPLchr7_73028930_7302908114860.3257240.245.4e-01Click!
MLXIPLchr7_73021530_7302173288600.1419630.235.6e-01Click!
MLXIPLchr7_73038945_730390961470.9415430.186.4e-01Click!
MLXIPLchr7_73037398_7303761113180.358771-0.137.5e-01Click!
MLXIPLchr7_73038556_73038914870.9593100.088.4e-01Click!

Activity of the MLXIPL motif across conditions

Conditions sorted by the z-value of the MLXIPL motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_114965108_114965301 0.28 CDC16
 cell division cycle 16
 35158
 0.14
chr22_46988879_46989444 0.21 GRAMD4
 GRAM domain containing 4
 16135
 0.21
chr16_89042817_89042968 0.16 CBFA2T3
 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
 509
 0.75
chr16_1429359_1429577 0.15 ENSG00000265529
 .
 44
 0.66
chr19_38423084_38423604 0.15 SIPA1L3
 signal-induced proliferation-associated 1 like 3
 25476
 0.15
chr8_13423939_13424235 0.15 C8orf48
 chromosome 8 open reading frame 48
 265
 0.93
chr10_20106092_20106642 0.14 PLXDC2
 plexin domain containing 2
 1199
 0.49
chr4_156589035_156589493 0.14 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
 449
 0.88
chr17_3819186_3819649 0.13 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
 377
 0.84
chr15_39871853_39872515 0.13 THBS1
 thrombospondin 1
 1096
 0.52
chr7_37325864_37326015 0.13 ELMO1
 engulfment and cell motility 1
 56428
 0.13
chr15_33010722_33010990 0.13 GREM1
 gremlin 1, DAN family BMP antagonist
 651
 0.73
chr11_47399612_47399968 0.13 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
 152
 0.91
chr18_12253921_12254616 0.13 CIDEA
 cell death-inducing DFFA-like effector a
 50
 0.98
chr2_160918347_160919586 0.13 PLA2R1
 phospholipase A2 receptor 1, 180kDa
 155
 0.98
chr16_3057439_3057643 0.13 LA16c-380H5.2
2439
 0.09
chr9_101014697_101014848 0.13 TBC1D2
 TBC1 domain family, member 2
 3090
 0.33
chr18_25755743_25755974 0.12 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 1552
 0.58
chr7_138348970_138349258 0.12 SVOPL
 SVOP-like
 145
 0.97
chr11_1328206_1328468 0.12 TOLLIP
 toll interacting protein
 2512
 0.21
chr20_3766593_3766776 0.12 CENPB
 centromere protein B, 80kDa
 653
 0.45
chr17_55939321_55939589 0.12 CUEDC1
 CUE domain containing 1
 5321
 0.19
chr6_144357186_144358268 0.12 PLAGL1
 pleiomorphic adenoma gene-like 1
 28008
 0.21
chr19_33685813_33686340 0.11 LRP3
 low density lipoprotein receptor-related protein 3
 586
 0.65
chr6_125684588_125685144 0.11 RP11-735G4.1
10604
 0.27
chr10_97049818_97050125 0.11 PDLIM1
 PDZ and LIM domain 1
 810
 0.7
chr7_27190086_27190291 0.11 HOXA-AS3
 HOXA cluster antisense RNA 3
 517
 0.49
chr11_68082046_68082433 0.11 LRP5
 low density lipoprotein receptor-related protein 5
 2162
 0.35
chr17_34599013_34599342 0.11 TBC1D3C
 TBC1 domain family, member 3C
 7145
 0.15
chr2_238768253_238768964 0.11 RAMP1
 receptor (G protein-coupled) activity modifying protein 1
 11
 0.98
chr12_113860437_113860657 0.11 SDSL
 serine dehydratase-like
 289
 0.88
chr5_121647834_121648295 0.11 SNCAIP
 synuclein, alpha interacting protein
 132
 0.9
chr2_208365436_208365587 0.11 CREB1
 cAMP responsive element binding protein 1
 28950
 0.18
chr2_45395914_45396553 0.11 SIX2
 SIX homeobox 2
 159664
 0.04
chr6_150464730_150464955 0.11 PPP1R14C
 protein phosphatase 1, regulatory (inhibitor) subunit 14C
 630
 0.74
chr16_70719186_70719575 0.11 MTSS1L
 metastasis suppressor 1-like
 589
 0.67
chr1_178063691_178064117 0.11 RASAL2
 RAS protein activator like 2
 628
 0.84
chr6_72129322_72130506 0.11 ENSG00000207827
 .
 16590
 0.22
chr2_109211293_109211679 0.11 LIMS1
 LIM and senescent cell antigen-like domains 1
 6564
 0.25
chr17_34510955_34511411 0.11 AC131056.3
342
 0.79
chr3_43811358_43811652 0.11 ABHD5
 abhydrolase domain containing 5
 58306
 0.14
chr7_158996146_158996297 0.11 VIPR2
 vasoactive intestinal peptide receptor 2
 58572
 0.16
chr6_54711000_54712080 0.11 FAM83B
 family with sequence similarity 83, member B
 29
 0.98
chr12_562387_562595 0.11 B4GALNT3
 beta-1,4-N-acetyl-galactosaminyl transferase 3
 7039
 0.21
chr19_8559121_8559517 0.11 PRAM1
 PML-RARA regulated adaptor molecule 1
 8176
 0.12
chr3_149094469_149095370 0.10 TM4SF1-AS1
 TM4SF1 antisense RNA 1
 646
 0.47
chr1_231163919_231164070 0.10 ENSG00000221290
 .
 8324
 0.15
chr22_50608207_50608432 0.10 PANX2
 pannexin 2
 841
 0.41
chr10_29010987_29011704 0.10 ENSG00000201001
 .
 38387
 0.14
chr11_13031575_13031768 0.10 ENSG00000266625
 .
 46484
 0.16
chr6_39281750_39281998 0.10 KCNK17
 potassium channel, subfamily K, member 17
 363
 0.89
chr8_11057742_11057983 0.10 XKR6
 XK, Kell blood group complex subunit-related family, member 6
 986
 0.53
chr3_35680671_35680927 0.10 ARPP21
 cAMP-regulated phosphoprotein, 21kDa
 282
 0.93
chr20_50720613_50721041 0.10 ZFP64
 ZFP64 zinc finger protein
 562
 0.86
chr14_103058041_103058305 0.10 RCOR1
 REST corepressor 1
 825
 0.6
chr6_116719287_116719943 0.10 DSE
 dermatan sulfate epimerase
 27505
 0.14
chr4_134071254_134071890 0.10 PCDH10
 protocadherin 10
 1102
 0.7
chr13_21634768_21635319 0.10 LATS2
 large tumor suppressor kinase 2
 614
 0.69
chr20_25213879_25214247 0.10 AL035252.1
 HCG2018895; Uncharacterized protein
 6693
 0.16
chr1_213090021_213090397 0.10 VASH2
 vasohibin 2
 33653
 0.16
chr18_74534859_74535018 0.10 ZNF236
 zinc finger protein 236
 375
 0.68
chr10_28968795_28969240 0.10 BAMBI
 BMP and activin membrane-bound inhibitor
 2746
 0.26
chr16_89630259_89630469 0.10 RPL13
 ribosomal protein L13
 1586
 0.22
chr1_181455162_181455370 0.10 CACNA1E
 calcium channel, voltage-dependent, R type, alpha 1E subunit
 2385
 0.45
chr11_94501626_94502525 0.10 AMOTL1
 angiomotin like 1
 538
 0.82
chr12_16501800_16502026 0.10 MGST1
 microsomal glutathione S-transferase 1
 1182
 0.59
chr12_120662282_120662577 0.09 PXN
 paxillin
 124
 0.94
chr1_65613306_65613822 0.09 AK4
 adenylate kinase 4
 51
 0.98
chr2_91635039_91635306 0.09 IGKV1OR2-118
 immunoglobulin kappa variable 1/OR2-118 (pseudogene)
 43915
 0.21
chrX_9754895_9755291 0.09 SHROOM2
 shroom family member 2
 597
 0.54
chr4_157890038_157890662 0.09 PDGFC
 platelet derived growth factor C
 1705
 0.41
chr16_81466874_81467025 0.09 CMIP
 c-Maf inducing protein
 11826
 0.23
chr16_89043094_89043288 0.09 CBFA2T3
 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
 210
 0.92
chr18_52626293_52626952 0.09 CCDC68
 coiled-coil domain containing 68
 117
 0.97
chr17_47077080_47077320 0.09 IGF2BP1
 insulin-like growth factor 2 mRNA binding protein 1
 2092
 0.16
chr8_125739093_125740062 0.09 MTSS1
 metastasis suppressor 1
 280
 0.94
chr18_52495652_52496658 0.09 RAB27B
 RAB27B, member RAS oncogene family
 725
 0.77
chr5_146832482_146833250 0.09 DPYSL3
 dihydropyrimidinase-like 3
 385
 0.91
chr11_61448104_61448359 0.09 DAGLA
 diacylglycerol lipase, alpha
 326
 0.89
chr11_3181150_3181578 0.09 OSBPL5
 oxysterol binding protein-like 5
 1259
 0.4
chr3_157820963_157821448 0.09 SHOX2
 short stature homeobox 2
 1878
 0.36
chr6_43044172_43044516 0.09 PTK7
 protein tyrosine kinase 7
 208
 0.85
chrX_151141627_151141778 0.09 GABRE
 gamma-aminobutyric acid (GABA) A receptor, epsilon
 1441
 0.33
chr2_62798336_62798579 0.09 TMEM17
 transmembrane protein 17
 64981
 0.11
chr15_83875054_83875562 0.09 HDGFRP3
 Hepatoma-derived growth factor-related protein 3
 1462
 0.4
chr5_156886857_156887334 0.09 CTB-109A12.1
9
 0.54
chr16_70729499_70729650 0.09 VAC14
 Vac14 homolog (S. cerevisiae)
 78
 0.96
chr4_185268825_185269197 0.09 ENSG00000244512
 .
 68922
 0.09
chr16_23912477_23912952 0.09 PRKCB
 protein kinase C, beta
 64170
 0.12
chr12_63328180_63328595 0.09 PPM1H
 protein phosphatase, Mg2+/Mn2+ dependent, 1H
 430
 0.76
chr12_88973452_88974158 0.09 KITLG
 KIT ligand
 433
 0.82
chr14_106376117_106376268 0.09 ENSG00000228131
 .
 94
 0.69
chr4_91049201_91049889 0.09 CCSER1
 coiled-coil serine-rich protein 1
 809
 0.78
chr4_41215795_41216596 0.09 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 280
 0.92
chr21_46573548_46573916 0.09 ADARB1
 adenosine deaminase, RNA-specific, B1
 17825
 0.17
chr11_747907_748726 0.09 TALDO1
 transaldolase 1
 888
 0.33
chr16_31276973_31277152 0.09 ENSG00000252876
 .
 1750
 0.22
chr10_72431780_72432013 0.09 ADAMTS14
 ADAM metallopeptidase with thrombospondin type 1 motif, 14
 663
 0.78
chr9_139929883_139930034 0.09 FUT7
 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
 2496
 0.09
chr4_57976289_57976477 0.08 IGFBP7
 insulin-like growth factor binding protein 7
 168
 0.72
chr16_85603204_85603491 0.08 GSE1
 Gse1 coiled-coil protein
 41668
 0.16
chr21_44831868_44832019 0.08 SIK1
 salt-inducible kinase 1
 15065
 0.27
chrX_10587548_10588615 0.08 MID1
 midline 1 (Opitz/BBB syndrome)
 378
 0.91
chr10_18429523_18430148 0.08 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
 52
 0.99
chr19_1017181_1017478 0.08 TMEM259
 transmembrane protein 259
 93
 0.91
chr18_31157392_31158104 0.08 ASXL3
 additional sex combs like 3 (Drosophila)
 848
 0.76
chr11_11642193_11642674 0.08 GALNT18
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18
 1119
 0.56
chr11_3043840_3044115 0.08 CARS-AS1
 CARS antisense RNA 1
 6647
 0.13
chrX_51637827_51638413 0.08 MAGED1
 melanoma antigen family D, 1
 1385
 0.5
chr7_70159815_70160908 0.08 AUTS2
 autism susceptibility candidate 2
 33764
 0.25
chr11_67210518_67210749 0.08 CORO1B
 coronin, actin binding protein, 1B
 310
 0.72
chr15_38545953_38546360 0.08 SPRED1
 sprouty-related, EVH1 domain containing 1
 774
 0.79
chr5_150021079_150021262 0.08 SYNPO
 synaptopodin
 930
 0.5
chr15_99558654_99558941 0.08 PGPEP1L
 pyroglutamyl-peptidase I-like
 7773
 0.22
chr19_16556537_16556749 0.08 CTD-2013N17.4
4886
 0.15
chr20_36433171_36433322 0.08 CTNNBL1
 catenin, beta like 1
 27571
 0.22
chr15_80270114_80270265 0.08 BCL2A1
 BCL2-related protein A1
 6401
 0.2
chr16_57723286_57723437 0.08 CCDC135
 coiled-coil domain containing 135
 5344
 0.14
chr14_53301814_53302501 0.08 FERMT2
 fermitin family member 2
 29082
 0.15
chr14_100204275_100204562 0.08 EML1
 echinoderm microtubule associated protein like 1
 332
 0.9
chr14_72050667_72050818 0.08 SIPA1L1
 signal-induced proliferation-associated 1 like 1
 2256
 0.45
chr9_137393023_137393337 0.08 RXRA
 retinoid X receptor, alpha
 94752
 0.07
chr3_159482295_159482916 0.08 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 287
 0.9
chr16_88218272_88218475 0.08 BANP
 BTG3 associated nuclear protein
 214749
 0.02
chr7_116311713_116312022 0.08 MET
 met proto-oncogene
 577
 0.82
chr14_38053784_38053935 0.08 FOXA1
 forkhead box A1
 10380
 0.23
chr3_123602332_123603013 0.08 MYLK
 myosin light chain kinase
 477
 0.85
chr6_78172796_78173983 0.08 HTR1B
 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
 101
 0.99
chr17_56348208_56348359 0.08 MPO
 myeloperoxidase
 2570
 0.2
chr18_74178798_74178949 0.08 ZNF516
 zinc finger protein 516
 23862
 0.16
chr8_127837007_127837644 0.08 ENSG00000212451
 .
 153558
 0.04
chr9_140345898_140346049 0.08 NSMF
 NMDA receptor synaptonuclear signaling and neuronal migration factor
 2971
 0.16
chr9_130308551_130308785 0.08 FAM129B
 family with sequence similarity 129, member B
 22699
 0.15
chrX_76703737_76703926 0.08 FGF16
 fibroblast growth factor 16
 5817
 0.34
chr1_158087708_158088406 0.08 KIRREL
 kin of IRRE like (Drosophila)
 31587
 0.18
chr12_66218806_66219120 0.08 HMGA2
 high mobility group AT-hook 2
 60
 0.98
chr10_54074428_54074776 0.08 DKK1
 dickkopf WNT signaling pathway inhibitor 1
 546
 0.57
chr3_72396838_72397278 0.08 ENSG00000212070
 .
 85479
 0.1
chr20_19193596_19194206 0.08 RP11-97N19.2
220
 0.81
chr5_159739674_159740114 0.08 CCNJL
 cyclin J-like
 287
 0.9
chr1_15484794_15484945 0.08 TMEM51
 transmembrane protein 51
 4584
 0.24
chr1_196577911_196578299 0.08 KCNT2
 potassium channel, subfamily T, member 2
 250
 0.94
chr13_95619763_95620412 0.08 ENSG00000252335
 .
 51402
 0.18
chrX_130962862_130963372 0.08 ENSG00000200587
 .
 109867
 0.07
chr11_17756507_17757113 0.08 KCNC1
 potassium voltage-gated channel, Shaw-related subfamily, member 1
 451
 0.83
chr14_106383409_106383560 0.08 ENSG00000211931
 .
 769
 0.15
chr6_14453382_14453777 0.08 ENSG00000206960
 .
 193187
 0.03
chr17_75278220_75278512 0.08 SEPT9
 septin 9
 833
 0.68
chr10_71812550_71812868 0.08 H2AFY2
 H2A histone family, member Y2
 73
 0.98
chr2_24307248_24307399 0.08 TP53I3
 tumor protein p53 inducible protein 3
 127
 0.94
chr2_220435062_220435638 0.07 OBSL1
 obscurin-like 1
 613
 0.46
chr11_24518160_24518510 0.07 LUZP2
 leucine zipper protein 2
 389
 0.91
chr1_204098492_204098674 0.07 RP11-74C13.4
1607
 0.3
chr19_41104181_41104507 0.07 LTBP4
 latent transforming growth factor beta binding protein 4
 1203
 0.38
chr15_82338737_82339392 0.07 MEX3B
 mex-3 RNA binding family member B
 582
 0.73
chr18_61498851_61499100 0.07 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
 39951
 0.14
chr17_80175288_80175536 0.07 RP13-516M14.2
3309
 0.13
chr19_14886701_14887039 0.07 EMR2
 egf-like module containing, mucin-like, hormone receptor-like 2
 698
 0.62
chr19_45121599_45121750 0.07 IGSF23
 immunoglobulin superfamily, member 23
 4434
 0.17
chr17_68165729_68165994 0.07 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 185
 0.66
chr4_188916560_188916711 0.07 ZFP42
 ZFP42 zinc finger protein
 290
 0.94
chr20_61467867_61468113 0.07 COL9A3
 collagen, type IX, alpha 3
 18827
 0.11
chr20_23065943_23066176 0.07 CD93
 CD93 molecule
 918
 0.56
chr2_62887339_62887490 0.07 AC092155.4
2349
 0.33
chr12_124990844_124991534 0.07 NCOR2
 nuclear receptor corepressor 2
 11391
 0.3
chr10_122216781_122217284 0.07 PPAPDC1A
 phosphatidic acid phosphatase type 2 domain containing 1A
 273
 0.93
chr7_119913514_119913995 0.07 KCND2
 potassium voltage-gated channel, Shal-related subfamily, member 2
 32
 0.99
chr15_99557644_99557868 0.07 PGPEP1L
 pyroglutamyl-peptidase I-like
 6732
 0.23
chr7_1963923_1964074 0.07 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 16187
 0.23
chr19_680149_680337 0.07 FSTL3
 follistatin-like 3 (secreted glycoprotein)
 2301
 0.16
chr14_93552815_93553084 0.07 ITPK1-AS1
 ITPK1 antisense RNA 1
 19152
 0.18
chr5_77943226_77943942 0.07 LHFPL2
 lipoma HMGIC fusion partner-like 2
 1064
 0.69
chr3_44063258_44064101 0.07 ENSG00000252980
 .
 48900
 0.17
chr2_159825200_159826543 0.07 TANC1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 688
 0.73
chr7_5467738_5468320 0.07 TNRC18
 trinucleotide repeat containing 18
 2984
 0.19
chr5_141293636_141294105 0.07 KIAA0141
 KIAA0141
 9503
 0.15
chr4_151504492_151504761 0.07 MAB21L2
 mab-21-like 2 (C. elegans)
 1549
 0.43
chr16_3156089_3156516 0.07 RP11-473M20.11
463
 0.57
chr8_37555995_37556200 0.07 ZNF703
 zinc finger protein 703
 2828
 0.18
chr16_81790383_81790667 0.07 PLCG2
 phospholipase C, gamma 2 (phosphatidylinositol-specific)
 17823
 0.27
chr14_59104798_59105385 0.07 DACT1
 dishevelled-binding antagonist of beta-catenin 1
 194
 0.97
chr19_48928010_48928416 0.07 GRWD1
 glutamate-rich WD repeat containing 1
 20817
 0.09
chr14_70170115_70170348 0.07 SRSF5
 serine/arginine-rich splicing factor 5
 23386
 0.21
chr7_116312458_116312799 0.07 MET
 met proto-oncogene
 169
 0.97
chr1_198901485_198902338 0.07 ENSG00000207759
 .
 73629
 0.11
chr1_156426947_156427327 0.07 MEF2D
 myocyte enhancer factor 2D
 26085
 0.1
chr7_5466302_5466453 0.07 TNRC18
 trinucleotide repeat containing 18
 1332
 0.35
chr4_157997002_157997188 0.07 GLRB
 glycine receptor, beta
 114
 0.97
chr9_96717847_96718052 0.07 BARX1
 BARX homeobox 1
 295
 0.94
chr11_64099501_64099713 0.07 AP003774.1
2631
 0.11
chr2_106008139_106008408 0.07 FHL2
 four and a half LIM domains 2
 4969
 0.21
chr7_95546876_95547027 0.07 DYNC1I1
 dynein, cytoplasmic 1, intermediate chain 1
 113355
 0.07
chr16_57576641_57576837 0.07 GPR114
 G protein-coupled receptor 114
 138
 0.95
chr9_137809478_137809629 0.07 FCN1
 ficolin (collagen/fibrinogen domain containing) 1
 256
 0.88
chr15_25123043_25123575 0.07 ENSG00000238615
 .
 15585
 0.12
chr6_27205685_27206711 0.07 PRSS16
 protease, serine, 16 (thymus)
 9282
 0.19
chr2_85632386_85633119 0.07 CAPG
 capping protein (actin filament), gelsolin-like
 3186
 0.11
chr1_208137959_208138110 0.07 CD34
 CD34 molecule
 53287
 0.17
chr19_8567028_8567223 0.07 PRAM1
 PML-RARA regulated adaptor molecule 1
 370
 0.79
chr16_54407600_54408115 0.07 IRX3
 iroquois homeobox 3
 87182
 0.09

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of MLXIPL

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1 0.1 GO:0060462 lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.1 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.0 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.1 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.1 GO:0001820 serotonin secretion(GO:0001820)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0060912 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.0 GO:0003148 outflow tract septum morphogenesis(GO:0003148)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0048342 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.1 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.0 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.0 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.0 0.0 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0019322 pentose biosynthetic process(GO:0019322)
0.0 0.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.0 GO:0051873 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.0 GO:0003416 endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.1 GO:0070977 organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0 0.1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.0 GO:0010916 regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0 0.1 GO:0006991 response to sterol depletion(GO:0006991)
0.0 0.0 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.1 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.0 GO:0030540 female genitalia development(GO:0030540)
0.0 0.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.1 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0060071 Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.4 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.1 GO:0006554 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0060900 optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0 0.1 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.0 GO:0060536 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.0 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 0.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0051549 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.2 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0021781 glial cell fate commitment(GO:0021781)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.0 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.0 GO:0045990 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.0 GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0 0.2 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0090102 cochlea development(GO:0090102)
0.0 0.0 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.0 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.0 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.0 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.0 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.0 GO:0043256 laminin complex(GO:0043256)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.0 GO:0070820 tertiary granule(GO:0070820)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0016585 obsolete chromatin remodeling complex(GO:0016585)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.2 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.2 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.0 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.0 GO:0034648 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.0 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.0 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.0 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.0 GO:0001846 opsonin binding(GO:0001846)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0 0.0 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.0 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.0 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.0 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.0 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.0 REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION Genes involved in E2F mediated regulation of DNA replication
0.0 0.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis