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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for MLX_USF2_USF1_PAX2

Z-value: 1.23

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Gene Symbol	Gene ID	Gene Info
MLX Ensembl NCBI GeneCards UniProt	ENSG00000108788.7	MAX dimerization protein MLX
USF2 Ensembl NCBI GeneCards UniProt	ENSG00000105698.11	upstream transcription factor 2, c-fos interacting
USF1 Ensembl NCBI GeneCards UniProt	ENSG00000158773.10	upstream transcription factor 1
PAX2 Ensembl NCBI GeneCards UniProt	ENSG00000075891.17	paired box 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_40719513_40720031	MLX	680	0.450555	0.78	1.3e-02	Click!
chr17_40719217_40719503	MLX	268	0.794788	0.78	1.3e-02	Click!
chr17_40718813_40719216	MLX	72	0.928407	0.65	5.8e-02	Click!
chr10_102490645_102490857	PAX2	14717	0.235970	0.71	3.1e-02	Click!
chr10_102497346_102497574	PAX2	8008	0.254579	0.69	3.9e-02	Click!
chr10_102414163_102414356	PAX2	91209	0.068494	0.61	8.2e-02	Click!
chr10_102414840_102414991	PAX2	90553	0.069282	0.51	1.6e-01	Click!
chr10_102490453_102490604	PAX2	14940	0.235454	0.50	1.7e-01	Click!
chr1_161015245_161015686	USF1	198	0.869665	0.96	2.9e-05	Click!
chr1_161015832_161016049	USF1	173	0.886637	0.88	1.6e-03	Click!
chr1_161014942_161015228	USF1	354	0.739730	0.86	3.2e-03	Click!
chr1_161014456_161014882	USF1	62	0.939571	0.81	8.3e-03	Click!
chr1_161016115_161016266	USF1	423	0.677451	0.64	6.3e-02	Click!
chr19_35758325_35758961	USF2	1238	0.254951	0.85	4.0e-03	Click!
chr19_35759494_35759654	USF2	307	0.777066	0.61	8.3e-02	Click!
chr19_35760287_35760594	USF2	422	0.674240	0.53	1.4e-01	Click!
chr19_35759189_35759340	USF2	617	0.517168	0.50	1.7e-01	Click!
chr19_35760748_35760986	USF2	299	0.784561	0.41	2.8e-01	Click!

Activity of the MLX_USF2_USF1_PAX2 motif across conditions

Conditions sorted by the z-value of the MLX_USF2_USF1_PAX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_202896403_202896578	1.17	KLHL12	kelch-like family member 12	100	0.95
chr20_4795670_4795862	1.09	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	3	0.98
chr19_4402510_4402661	0.89	CHAF1A	chromatin assembly factor 1, subunit A (p150)	74	0.93
chr17_6915641_6915886	0.78	RNASEK	ribonuclease, RNase K	27	0.55
chr3_19988451_19988692	0.67	RAB5A	RAB5A, member RAS oncogene family	0	0.54
chr10_70480705_70480856	0.65	CCAR1	cell division cycle and apoptosis regulator 1	11	0.97
chr12_90103095_90103246	0.61	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	93	0.97
chr1_154193354_154193505	0.58	UBAP2L	ubiquitin associated protein 2-like	6	0.81
chr14_21852235_21852445	0.58	SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	85	0.52
chr17_17140687_17141182	0.56	FLCN	folliculin	438	0.74
chr3_13460524_13460714	0.55	NUP210	nucleoporin 210kDa	1190	0.56
chr5_171542027_171542178	0.50	ENSG00000266671	.	34122	0.17
chr13_49684124_49684410	0.50	FNDC3A	fibronectin type III domain containing 3A	182	0.96
chr19_10764777_10764928	0.48	ILF3	interleukin enhancer binding factor 3, 90kDa	85	0.95
chr19_49457811_49458033	0.48	BAX	BCL2-associated X protein	195	0.85
chr16_84401582_84401733	0.47	ATP2C2	ATPase, Ca++ transporting, type 2C, member 2	476	0.82
chr17_47841796_47842381	0.46	FAM117A	family with sequence similarity 117, member A	559	0.72
chrY_1604612_1604993	0.46	NA	NA	> 10⁶	NA
chr3_184031996_184032281	0.46	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	145	0.91
chr5_139782206_139782432	0.46	ANKHD1	ankyrin repeat and KH domain containing 1	813	0.3
chr7_100271099_100271250	0.45	GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	16	0.95
chr11_126081501_126081652	0.45	RPUSD4	RNA pseudouridylate synthase domain containing 4	11	0.56
chrX_1654663_1654996	0.45	P2RY8	purinergic receptor P2Y, G-protein coupled, 8	1171	0.53
chr12_123849561_123849862	0.44	SBNO1	strawberry notch homolog 1 (Drosophila)	321	0.85
chr15_68132393_68132701	0.44	ENSG00000206625	.	164	0.97
chr1_222885954_222886552	0.43	AIDA	axin interactor, dorsalization associated	273	0.56
chr11_118094529_118095128	0.43	AMICA1	adhesion molecule, interacts with CXADR antigen 1	26	0.97
chr1_42921657_42922194	0.42	ZMYND12	zinc finger, MYND-type containing 12	13	0.64
chr16_15737211_15737772	0.41	ENSG00000272213	.	340	0.38
chr3_148709208_148709359	0.41	GYG1	glycogenin 1	16	0.98
chr19_15575302_15575574	0.41	RASAL3	RAS protein activator like 3	56	0.96
chr9_131084429_131084680	0.41	TRUB2	TruB pseudouridine (psi) synthase family member 2	57	0.74
chr16_745521_745735	0.40	FBXL16	F-box and leucine-rich repeat protein 16	397	0.57
chr10_3822916_3823697	0.40	KLF6	Kruppel-like factor 6	4079	0.25
chr12_46777195_46777346	0.39	SLC38A2	solute carrier family 38, member 2	10620	0.24
chr9_96793015_96793166	0.39	PTPDC1	protein tyrosine phosphatase domain containing 1	14	0.99
chr9_125667781_125668094	0.39	RC3H2	ring finger and CCCH-type domains 2	317	0.82
chr15_74392593_74392993	0.38	GOLGA6A	golgin A6 family, member A	17902	0.12
chr2_6868388_6868539	0.38	AC017076.5		105199	0.07
chr6_106439645_106440509	0.38	ENSG00000200198	.	87829	0.09
chr9_131450959_131451258	0.38	SET	SET nuclear oncogene	397	0.73
chr10_46090174_46090398	0.37	MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	68	0.98
chr19_11546030_11546251	0.37	PRKCSH	protein kinase C substrate 80K-H	31	0.69
chr19_3990141_3990406	0.37	EEF2	eukaryotic translation elongation factor 2	4806	0.11
chr17_75451832_75452118	0.37	SEPT9	septin 9	473	0.77
chr16_28306637_28306788	0.37	SBK1	SH3 domain binding kinase 1	2872	0.28
chr14_91879963_91880132	0.36	CCDC88C	coiled-coil domain containing 88C	3643	0.29
chrX_100872700_100873033	0.35	ARMCX6	armadillo repeat containing, X-linked 6	125	0.93
chr20_18118508_18118767	0.35	PET117	PET117 homolog (S. cerevisiae)	120	0.5
chr8_142427875_142428034	0.34	PTP4A3	protein tyrosine phosphatase type IVA, member 3	4053	0.16
chr7_150065813_150066064	0.34	REPIN1	replication initiator 1	22	0.52
chr5_1800677_1801081	0.34	MRPL36	mitochondrial ribosomal protein L36	601	0.45
chr17_48450293_48450521	0.33	MRPL27	mitochondrial ribosomal protein L27	86	0.61
chrX_154012790_154012941	0.33	ENSG00000206693	.	9592	0.11
chr9_132388509_132388893	0.33	NTMT1	N-terminal Xaa-Pro-Lys N-methyltransferase 1	22	0.96
chrX_71002679_71002935	0.32	ENSG00000221684	.	23502	0.23
chr11_117857636_117858098	0.32	IL10RA	interleukin 10 receptor, alpha	758	0.66
chr17_66201588_66201894	0.32	AMZ2	archaelysin family metallopeptidase 2	41974	0.12
chr15_34610151_34611295	0.32	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	257	0.87
chr3_177040689_177040840	0.32	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	125503	0.06
chr13_52377985_52378296	0.31	DHRS12	dehydrogenase/reductase (SDR family) member 12	94	0.76
chr10_129706310_129706549	0.31	PTPRE	protein tyrosine phosphatase, receptor type, E	1013	0.58
chr2_27805637_27805914	0.30	ZNF512	zinc finger protein 512	122	0.9
chr10_74114795_74115085	0.30	DNAJB12	DnaJ (Hsp40) homolog, subfamily B, member 12	33	0.98
chr3_31573575_31573846	0.30	STT3B	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	572	0.85
chrY_2709555_2710183	0.30	RPS4Y1	ribosomal protein S4, Y-linked 1	92	0.98
chr1_145611013_145611189	0.29	RNF115	ring finger protein 115	65	0.63
chr21_27443178_27443674	0.29	APP	amyloid beta (A4) precursor protein	18951	0.24
chr1_40283034_40283198	0.29	RP1-118J21.25		28468	0.11
chr10_22609853_22610108	0.29	BMI1	BMI1 polycomb ring finger oncogene	160	0.94
chr19_15236279_15236535	0.29	ILVBL	ilvB (bacterial acetolactate synthase)-like	63	0.94
chr2_174129320_174129481	0.29	MLK7-AS1	MLK7 antisense RNA 1	6948	0.3
chr1_101360427_101360745	0.29	RP4-549L20.3		102	0.63
chr1_154908770_154909108	0.29	PMVK	phosphomevalonate kinase	528	0.6
chr17_65821514_65821703	0.29	BPTF	bromodomain PHD finger transcription factor	32	0.97
chr6_170580859_170581356	0.28	RP5-1086L22.1		9450	0.18
chr11_67211190_67211466	0.28	CORO1B	coronin, actin binding protein, 1B	65	0.92
chrX_72783084_72783245	0.28	CHIC1	cysteine-rich hydrophobic domain 1	120	0.98
chr8_28259515_28259714	0.27	ZNF395	zinc finger protein 395	604	0.66
chrX_10066246_10067411	0.27	WWC3	WWC family member 3	35329	0.15
chrX_62780920_62781228	0.26	ENSG00000235437	.	123	0.98
chr17_25659717_25660000	0.26	WSB1	WD repeat and SOCS box containing 1	38486	0.16
chr7_116593207_116593413	0.26	ST7	suppression of tumorigenicity 7	18	0.9
chrX_102941872_102942023	0.26	MORF4L2	mortality factor 4 like 2	201	0.57
chr1_192128557_192128890	0.26	RGS18	regulator of G-protein signaling 18	1136	0.67
chr2_190305327_190305991	0.26	WDR75	WD repeat domain 75	500	0.87
chr16_25118548_25118859	0.26	LCMT1	leucine carboxyl methyltransferase 1	4347	0.25
chr8_38240572_38240933	0.26	WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	962	0.42
chr10_3871001_3871747	0.25	KLF6	Kruppel-like factor 6	43901	0.17
chr19_35939103_35939363	0.25	FFAR2	free fatty acid receptor 2	30	0.96
chr17_80406652_80406803	0.24	C17orf62	chromosome 17 open reading frame 62	754	0.43
chr22_40406174_40406325	0.24	FAM83F	family with sequence similarity 83, member F	557	0.75
chr7_50727728_50727879	0.24	GRB10	growth factor receptor-bound protein 10	33176	0.21
chr19_12886036_12886246	0.24	HOOK2	hook microtubule-tethering protein 2	196	0.83
chr17_21156722_21156881	0.24	C17orf103	chromosome 17 open reading frame 103	79	0.97
chr22_44422802_44422980	0.24	PARVB	parvin, beta	2734	0.33
chr5_94982218_94982535	0.24	RFESD	Rieske (Fe-S) domain containing	82	0.97
chr6_139350164_139350486	0.24	ABRACL	ABRA C-terminal like	346	0.91
chr6_24775111_24775564	0.23	GMNN	geminin, DNA replication inhibitor	171	0.94
chr15_75628080_75628612	0.23	COMMD4	COMM domain containing 4	15	0.96
chr8_1940470_1940621	0.23	KBTBD11	kelch repeat and BTB (POZ) domain containing 11	18501	0.24
chr15_87763305_87763456	0.23	RP11-133L19.1		231723	0.02
chr20_61916082_61916233	0.23	ENSG00000266104	.	2003	0.18
chr20_62530272_62530423	0.23	DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	3812	0.09
chr11_62538286_62538869	0.23	TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	198	0.69
chr10_112117242_112117393	0.23	SMNDC1	survival motor neuron domain containing 1	52608	0.13
chr9_100684535_100684760	0.23	C9orf156	chromosome 9 open reading frame 156	122	0.95
chr2_231090336_231091061	0.22	SP140	SP140 nuclear body protein	219	0.54
chr2_38871082_38871242	0.22	GALM	galactose mutarotase (aldose 1-epimerase)	21890	0.15
chr4_3529804_3529955	0.22	LRPAP1	low density lipoprotein receptor-related protein associated protein 1	4407	0.19
chr22_18252608_18252759	0.22	BID	BH3 interacting domain death agonist	4099	0.21
chr17_63053075_63053367	0.22	GNA13	guanine nucleotide binding protein (G protein), alpha 13	264	0.91
chr19_35615719_35615873	0.22	FXYD3	FXYD domain containing ion transport regulator 3	5529	0.1
chr2_240323140_240323402	0.22	AC062017.1	Uncharacterized protein	141	0.86
chr7_100292135_100292392	0.22	GIGYF1	GRB10 interacting GYF protein 1	5192	0.11
chr9_6703919_6704260	0.21	KDM4C	lysine (K)-specific demethylase 4C	16774	0.21
chr9_135996853_135997045	0.21	RALGDS	ral guanine nucleotide dissociation stimulator	386	0.81
chr19_13215586_13215874	0.21	LYL1	lymphoblastic leukemia derived sequence 1	1755	0.21
chr8_27950757_27951396	0.21	ELP3	elongator acetyltransferase complex subunit 3	112	0.97
chrX_70918097_70918602	0.21	ENSG00000221684	.	60956	0.11
chr2_97439727_97440064	0.21	CNNM4	cyclin M4	13256	0.14
chr1_153508703_153508968	0.21	S100A6	S100 calcium binding protein A6	115	0.91
chr9_98278987_98279233	0.21	PTCH1	patched 1	137	0.95
chr8_17193981_17194132	0.21	MTMR7	myotubularin related protein 7	24874	0.21
chr10_69644313_69644464	0.21	SIRT1	sirtuin 1	39	0.98
chr22_25815435_25815828	0.20	LRP5L	low density lipoprotein receptor-related protein 5-like	14287	0.17
chr2_240302618_240303103	0.20	HDAC4	histone deacetylase 4	19783	0.17
chr2_1077533_1077684	0.20	AC114808.3		13581	0.26
chr6_150326465_150326645	0.20	RAET1K	retinoic acid early transcript 1K pseudogene	262	0.9
chr11_64648039_64648569	0.20	EHD1	EH-domain containing 1	1132	0.31
chr16_71879481_71879729	0.20	ATXN1L	ataxin 1-like	289	0.47
chr12_113623337_113623491	0.20	RITA1	RBPJ interacting and tubulin associated 1	67	0.58
chr3_172312310_172312617	0.20	AC007919.2	HCG1787166; PRO1163; Uncharacterized protein	49020	0.13
chr14_20929873_20930024	0.20	TMEM55B	transmembrane protein 55B	177	0.87
chr15_44083848_44084237	0.20	SERF2	small EDRK-rich factor 2	2	0.94
chrX_129040013_129040508	0.20	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	93	0.97
chr10_81962972_81963123	0.20	ANXA11	annexin A11	1200	0.51
chr4_39355902_39356119	0.20	RFC1	replication factor C (activator 1) 1, 145kDa	11959	0.16
chr13_33000514_33000892	0.20	N4BP2L1	NEDD4 binding protein 2-like 1	1448	0.44
chrX_102631036_102631748	0.20	NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1	57	0.97
chr3_49044093_49044679	0.20	WDR6	WD repeat domain 6	109	0.91
chr4_1195166_1195336	0.20	SPON2	spondin 2, extracellular matrix protein	3625	0.16
chrX_100603814_100604224	0.20	TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)	165	0.92
chr3_184078420_184078571	0.20	CLCN2	chloride channel, voltage-sensitive 2	895	0.31
chr7_140098327_140098552	0.20	SLC37A3	solute carrier family 37, member 3	90	0.96
chr19_47633889_47634040	0.20	SAE1	SUMO1 activating enzyme subunit 1	75	0.97
chr16_30075509_30076103	0.20	ALDOA	aldolase A, fructose-bisphosphate	12	0.94
chr20_48731883_48732067	0.19	UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	516	0.78
chr19_17236963_17237284	0.19	MYO9B	myosin IXB	24595	0.1
chr19_4829242_4829393	0.19	TICAM1	toll-like receptor adaptor molecule 1	2399	0.18
chr1_153918448_153918692	0.19	DENND4B	DENN/MADD domain containing 4B	602	0.54
chr1_53168822_53169232	0.19	COA7	cytochrome c oxidase assembly factor 7	4989	0.16
chr16_87887371_87887580	0.19	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	9770	0.17
chr19_10398277_10398487	0.19	ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	702	0.35
chr16_17463239_17463649	0.19	XYLT1	xylosyltransferase I	101294	0.09
chr18_77153881_77154299	0.19	NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	1766	0.42
chr9_132816560_132816877	0.19	GPR107	G protein-coupled receptor 107	733	0.67
chr5_94890508_94890791	0.19	TTC37	tetratricopeptide repeat domain 37	1	0.63
chr15_67813744_67814059	0.19	C15orf61	chromosome 15 open reading frame 61	132	0.97
chr7_127033071_127033491	0.19	ZNF800	zinc finger protein 800	509	0.84
chr10_23631569_23631720	0.19	RP11-371A19.2		1242	0.34
chr1_153939522_153939993	0.19	SLC39A1	solute carrier family 39 (zinc transporter), member 1	340	0.51
chr22_40307152_40307436	0.19	GRAP2	GRB2-related adaptor protein 2	10181	0.17
chr17_32906311_32906556	0.19	C17orf102	chromosome 17 open reading frame 102	45	0.97
chr2_190627024_190627494	0.19	OSGEPL1-AS1	OSGEPL1 antisense RNA 1	171	0.56
chr2_202987834_202988283	0.19	AC079354.3		6277	0.17
chr11_62538890_62539107	0.19	RP11-727F15.11		80	0.6
chr6_35744217_35744431	0.18	CLPSL2	colipase-like 2	68	0.96
chr6_169612787_169612938	0.18	XXyac-YX65C7_A.2		487	0.87
chr17_59299974_59300148	0.18	RP11-136H19.1		86736	0.08
chr20_35575234_35575857	0.18	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr7_48018318_48018852	0.18	HUS1	HUS1 checkpoint homolog (S. pombe)	516	0.79
chr16_66914092_66914355	0.18	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2	41	0.95
chr17_68183563_68183714	0.18	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	17962	0.2
chr4_164471433_164471640	0.18	ENSG00000264535	.	27092	0.19
chr13_21635697_21635989	0.18	LATS2	large tumor suppressor kinase 2	157	0.95
chr2_219736729_219736880	0.18	WNT10A	wingless-type MMTV integration site family, member 10A	8281	0.12
chr19_1439067_1439250	0.18	RPS15	ribosomal protein S15	352	0.66
chr2_46727092_46727710	0.18	RP11-417F21.2		531	0.73
chr7_2393496_2393740	0.18	EIF3B	eukaryotic translation initiation factor 3, subunit B	103	0.78
chr19_33166568_33166725	0.18	RGS9BP	regulator of G protein signaling 9 binding protein	333	0.61
chr17_7745282_7745470	0.18	KDM6B	lysine (K)-specific demethylase 6B	2096	0.17
chr8_41907411_41908748	0.18	KAT6A	K(lysine) acetyltransferase 6A	1426	0.43
chr19_2616954_2617105	0.18	CTC-265F19.2		5169	0.16
chr11_63706516_63706697	0.18	NAA40	N(alpha)-acetyltransferase 40, NatD catalytic subunit	114	0.94
chr8_103820133_103820297	0.18	AZIN1	antizyme inhibitor 1	50115	0.12
chr5_159866335_159866555	0.18	PTTG1	pituitary tumor-transforming 1	17528	0.13
chr20_18547706_18547912	0.18	DTD1	D-tyrosyl-tRNA deacylase 1	20728	0.11
chr3_119811799_119812619	0.18	GSK3B	glycogen synthase kinase 3 beta	304	0.9
chr13_80881448_80881599	0.17	SPRY2	sprouty homolog 2 (Drosophila)	32271	0.23
chr10_104223217_104223368	0.17	TMEM180	transmembrane protein 180	2122	0.16
chr6_135857324_135857475	0.17	AHI1	Abelson helper integration site 1	38485	0.19
chr9_34646531_34647052	0.17	GALT	galactose-1-phosphate uridylyltransferase	131	0.9
chr9_36572612_36572804	0.17	MELK	maternal embryonic leucine zipper kinase	151	0.98
chr21_43933401_43933705	0.17	SLC37A1	solute carrier family 37 (glucose-6-phosphate transporter), member 1	471	0.74
chr7_21938421_21938604	0.17	CDCA7L	cell division cycle associated 7-like	5365	0.3
chr7_1100114_1100265	0.17	RP11-449P15.1		1292	0.26
chr10_76073985_76074136	0.17	ADK	adenosine kinase	137539	0.04
chr14_105530971_105531214	0.17	GPR132	G protein-coupled receptor 132	675	0.7
chr21_46237823_46238060	0.17	SUMO3	small ubiquitin-like modifier 3	25	0.96

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.1	0.4	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1	0.6	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1	0.4	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	0.5	GO:0060009	Sertoli cell development(GO:0060009)
0.1	0.2	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.3	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.1	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.1	0.2	GO:0018343	protein farnesylation(GO:0018343)
0.1	0.2	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.1	0.2	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1	0.2	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0015809	arginine transport(GO:0015809)
0.0	0.1	GO:0000255	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.1	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.7	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.2	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.2	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.1	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.4	GO:0050812	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.6	GO:0016925	protein sumoylation(GO:0016925)
0.0	0.3	GO:0006983	ER overload response(GO:0006983)
0.0	0.2	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.2	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.2	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.6	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.1	GO:0019322	pentose biosynthetic process(GO:0019322)
0.0	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.5	GO:0009303	rRNA transcription(GO:0009303)
0.0	0.2	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.3	GO:0043496	regulation of protein homodimerization activity(GO:0043496)
0.0	0.1	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.3	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.4	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0071545	inositol phosphate catabolic process(GO:0071545)
0.0	0.2	GO:0046037	GMP metabolic process(GO:0046037)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
0.0	0.3	GO:0021903	rostrocaudal neural tube patterning(GO:0021903)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.3	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0071166	ribonucleoprotein complex localization(GO:0071166)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.3	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.3	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.6	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.0	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.0	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.1	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.2	GO:0051322	anaphase(GO:0051322)
0.0	0.1	GO:0071027	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0014002	astrocyte development(GO:0014002)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0006743	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.2	GO:0006084	acetyl-CoA metabolic process(GO:0006084)
0.0	0.1	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.1	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.4	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.0	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0046543	thelarche(GO:0042695) development of secondary female sexual characteristics(GO:0046543) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.1	GO:0051383	kinetochore organization(GO:0051383)
0.0	0.6	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	0.0	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.3	GO:0046627	negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0	0.1	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0034969	histone arginine methylation(GO:0034969)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.0	GO:0048525	negative regulation of viral process(GO:0048525) negative regulation of viral life cycle(GO:1903901)
0.0	0.1	GO:0061462	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.1	GO:0000266	mitochondrial fission(GO:0000266)
0.0	0.0	GO:0006530	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.1	GO:0006900	membrane budding(GO:0006900)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.0	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0050908	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	0.1	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0	0.1	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0	0.0	GO:2000189	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.0	GO:0048668	collateral sprouting(GO:0048668)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.0	0.1	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.1	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.0	GO:0032239	regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0001881	receptor recycling(GO:0001881)
0.0	0.1	GO:0034138	toll-like receptor 3 signaling pathway(GO:0034138)
0.0	0.2	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0051458	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0000726	non-recombinational repair(GO:0000726)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0043330	response to exogenous dsRNA(GO:0043330)
0.0	0.2	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	1.0	GO:0018196	peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.9	GO:0006754	ATP biosynthetic process(GO:0006754)
0.0	0.1	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0051024	positive regulation of immunoglobulin secretion(GO:0051024)
0.0	0.0	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.0	0.1	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.1	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.4	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0055070	copper ion homeostasis(GO:0055070)
0.0	1.7	GO:0006184	obsolete GTP catabolic process(GO:0006184)
0.0	0.1	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.0	GO:0019884	antigen processing and presentation of exogenous antigen(GO:0019884)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0010916	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.2	GO:0032648	regulation of interferon-beta production(GO:0032648)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.2	GO:0018904	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.2	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.0	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.0	GO:0002467	germinal center formation(GO:0002467)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.2	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201)
0.0	0.0	GO:0051299	centrosome separation(GO:0051299)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0048247	lymphocyte chemotaxis(GO:0048247) lymphocyte migration(GO:0072676)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0018202	peptidyl-histidine modification(GO:0018202)
0.0	0.1	GO:0006388	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0016137	glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0	0.1	GO:0000060	protein import into nucleus, translocation(GO:0000060)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313) mature B cell differentiation(GO:0002335)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.7	GO:0051028	mRNA transport(GO:0051028)
0.0	0.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.0	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0008333	endosome to lysosome transport(GO:0008333)
0.0	0.1	GO:0016114	terpenoid biosynthetic process(GO:0016114)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.2	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0048799	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.6	GO:0034134	toll-like receptor 1 signaling pathway(GO:0034130) toll-like receptor 2 signaling pathway(GO:0034134)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	1.9	GO:0000398	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0	0.1	GO:0032367	intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0	0.0	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.0	0.0	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	0.5	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.1	0.3	GO:0005827	polar microtubule(GO:0005827)
0.1	0.2	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	0.3	GO:0016589	NURF complex(GO:0016589)
0.1	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.1	0.7	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.4	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.4	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.2	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.6	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.0	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.3	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.2	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.3	GO:0030914	STAGA complex(GO:0030914)
0.0	0.5	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.0	GO:0000779	condensed chromosome, centromeric region(GO:0000779)
0.0	0.2	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.4	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.4	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.4	GO:0005844	polysome(GO:0005844)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.0	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.5	GO:0042641	actomyosin(GO:0042641)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.5	GO:0042645	mitochondrial nucleoid(GO:0042645)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.0	GO:0043230	extracellular organelle(GO:0043230)
0.0	0.3	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.5	GO:0015030	Cajal body(GO:0015030)
0.0	0.5	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.7	GO:0000776	kinetochore(GO:0000776)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.3	GO:0031526	brush border membrane(GO:0031526)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.6	GO:0005643	nuclear pore(GO:0005643)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.2	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	1.0	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.1	0.2	GO:0043398	HLH domain binding(GO:0043398)
0.1	0.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.4	GO:0070513	death domain binding(GO:0070513)
0.1	0.2	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.1	0.2	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	0.3	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.2	GO:0005113	patched binding(GO:0005113)
0.1	0.2	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.1	0.3	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.1	0.4	GO:0005536	glucose binding(GO:0005536)
0.1	0.2	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.3	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.6	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.2	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.2	GO:0015288	porin activity(GO:0015288)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.3	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.2	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.4	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.4	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.2	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.2	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.2	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.4	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.7	GO:0004521	endoribonuclease activity(GO:0004521)
0.0	0.3	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	1.0	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.5	GO:0019003	GDP binding(GO:0019003)
0.0	0.1	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.2	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.0	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.0	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.5	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.6	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.1	GO:0016679	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.3	GO:0019843	rRNA binding(GO:0019843)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.1	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0046969	histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.3	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.0	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.3	GO:0016776	phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0	0.2	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.4	GO:0003954	NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.0	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0019206	nucleoside kinase activity(GO:0019206)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	0.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.5	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.4	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.5	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	1.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.5	PID FOXO PATHWAY	FoxO family signaling
0.0	0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.3	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.2	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.2	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.1	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.6	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.3	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.1	PID EPO PATHWAY	EPO signaling pathway
0.0	0.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.1	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.4	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	Genes involved in trans-Golgi Network Vesicle Budding
0.3	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.4	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.8	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.3	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.1	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.4	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.7	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.3	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.6	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.2	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.5	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.9	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
1.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.3	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.3	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.6	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.5	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)

Results for MLX_USF2_USF1_PAX2

Z-value: 1.23

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the MLX_USF2_USF1_PAX2 motif across conditions

Conditions sorted by the z-value of the MLX_USF2_USF1_PAX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: