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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MSX1

Z-value: 0.80

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Transcription factors associated with MSX1

Gene Symbol	Gene ID	Gene Info
MSX1 Ensembl NCBI GeneCards UniProt	ENSG00000163132.6	MSX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MSX1	chr4_4873247_4873398	11929	0.255507	-0.61	8.0e-02	Click!
MSX1	chr4_4765683_4765834	95635	0.079346	-0.53	1.4e-01	Click!
MSX1	chr4_4873038_4873189	11720	0.256232	-0.51	1.6e-01	Click!
MSX1	chr4_4854523_4854767	6748	0.287695	0.50	1.7e-01	Click!
MSX1	chr4_4861125_4861397	132	0.976461	0.47	2.0e-01	Click!

Activity of the MSX1 motif across conditions

Conditions sorted by the z-value of the MSX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_38172411_38172686	0.47	POSTN	periostin, osteoblast specific factor	315	0.95
chr3_129468296_129468447	0.38	TMCC1	transmembrane and coiled-coil domain family 1	44888	0.13
chr6_1613704_1614304	0.35	FOXC1	forkhead box C1	3323	0.37
chr6_1612835_1613496	0.34	FOXC1	forkhead box C1	2484	0.42
chr1_234675056_234675207	0.31	ENSG00000212144	.	53890	0.11
chr3_189932576_189932727	0.28	ENSG00000212489	.	49339	0.13
chr3_29327656_29328192	0.27	RBMS3-AS3	RBMS3 antisense RNA 3	4293	0.26
chr9_4865980_4866131	0.26	AL158147.2	HCG2011465; Uncharacterized protein	6795	0.16
chr7_158609578_158609780	0.25	ESYT2	extended synaptotagmin-like protein 2	12484	0.24
chr1_172313169_172313650	0.25	ENSG00000252354	.	3874	0.23
chr8_10268256_10268407	0.25	RP11-981G7.1		22851	0.2
chr7_116347101_116347278	0.25	MET	met proto-oncogene	8050	0.26
chr15_93429972_93430811	0.25	CHD2	chromodomain helicase DNA binding protein 2	3865	0.22
chr11_14375529_14375805	0.24	RRAS2	related RAS viral (r-ras) oncogene homolog 2	379	0.91
chr18_19866097_19866248	0.24	ENSG00000238907	.	25633	0.19
chr5_106791734_106791885	0.23	EFNA5	ephrin-A5	214519	0.02
chr21_36256046_36256553	0.23	RUNX1	runt-related transcription factor 1	3181	0.38
chr8_83181283_83181434	0.23	SNX16	sorting nexin 16	426257	0.01
chr3_30289901_30290052	0.23	ENSG00000199927	.	56051	0.15
chr9_10292066_10292217	0.22	PTPRD	protein tyrosine phosphatase, receptor type, D	258351	0.02
chr2_225672771_225672922	0.22	DOCK10	dedicator of cytokinesis 10	8523	0.32
chr2_21445047_21445198	0.21	TDRD15	tudor domain containing 15	98333	0.09
chr9_114506322_114506473	0.21	C9orf84	chromosome 9 open reading frame 84	15416	0.21
chr4_61665381_61665532	0.21	ENSG00000265829	.	122881	0.06
chr6_155544928_155545289	0.20	TIAM2	T-cell lymphoma invasion and metastasis 2	7008	0.22
chr21_29172171_29172322	0.20	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	833414	0.0
chr16_1069426_1069639	0.20	SOX8	SRY (sex determining region Y)-box 8	37724	0.09
chr10_8635845_8635996	0.20	ENSG00000212505	.	62874	0.16
chr9_81871537_81871846	0.20	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	314997	0.01
chr5_94951954_94952105	0.20	GPR150	G protein-coupled receptor 150	3753	0.21
chr5_26332801_26332952	0.20	ENSG00000222560	.	319878	0.01
chr11_95906977_95907128	0.20	ENSG00000266192	.	167550	0.03
chr8_32407136_32407287	0.20	NRG1	neuregulin 1	966	0.71
chrY_17603350_17603501	0.20	ENSG00000252664	.	571221	0.0
chr22_46479348_46479691	0.19	FLJ27365	hsa-mir-4763	2364	0.16
chr10_80549668_80549819	0.19	ENSG00000223243	.	39384	0.22
chr3_134091064_134091340	0.19	AMOTL2	angiomotin like 2	448	0.85
chr3_49447935_49448923	0.19	RHOA	ras homolog family member A	932	0.32
chr15_93999319_93999470	0.19	ENSG00000212063	.	169842	0.04
chr4_43019583_43019734	0.19	GRXCR1	glutaredoxin, cysteine rich 1	124374	0.06
chr4_47491811_47491962	0.19	ATP10D	ATPase, class V, type 10D	4570	0.24
chr1_221330964_221331115	0.19	HLX	H2.0-like homeobox	276455	0.01
chr4_14728626_14728777	0.18	ENSG00000202449	.	36367	0.24
chr12_54089934_54090280	0.18	CALCOCO1	calcium binding and coiled-coil domain 1	18306	0.14
chr21_25900554_25900705	0.18	ENSG00000232512	.	572816	0.0
chr7_113054663_113054814	0.18	TSRM	Uncharacterized protein; Zinc finger domain-related protein TSRM	36389	0.24
chr1_113447611_113447762	0.18	SLC16A1	solute carrier family 16 (monocarboxylate transporter), member 1	30924	0.18
chr17_2879197_2879355	0.18	CTD-3060P21.1		10087	0.23
chr9_74377079_74377230	0.18	TMEM2	transmembrane protein 2	6148	0.31
chr11_39124455_39124606	0.18	ENSG00000201591	.	158127	0.04
chr1_244504765_244505074	0.18	C1orf100	chromosome 1 open reading frame 100	11018	0.25
chr4_184558081_184558479	0.18	ENSG00000252157	.	16549	0.14
chr6_69548767_69548918	0.18	BAI3	brain-specific angiogenesis inhibitor 3	203583	0.03
chr10_20208323_20208474	0.18	PLXDC2	plexin domain containing 2	103230	0.07
chr16_82664556_82664707	0.18	CDH13	cadherin 13	3933	0.35
chr7_55638778_55639418	0.18	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	463	0.8
chr10_63843987_63844138	0.18	ENSG00000221094	.	31912	0.19
chr4_146467351_146467609	0.18	SMAD1-AS1	SMAD1 antisense RNA 1	29210	0.17
chr2_189198683_189198972	0.18	ENSG00000207951	.	36608	0.17
chr15_67374785_67374936	0.17	SMAD3	SMAD family member 3	16060	0.25
chr2_134432207_134432889	0.17	ENSG00000200708	.	78886	0.11
chr2_113545549_113545700	0.17	IL1A	interleukin 1, alpha	3457	0.21
chr20_43975692_43975843	0.17	SDC4	syndecan 4	1297	0.32
chr15_64813512_64813804	0.17	ZNF609	zinc finger protein 609	22167	0.15
chr6_1798343_1798634	0.17	FOXC1	forkhead box C1	187807	0.03
chr1_189407668_189407819	0.17	ENSG00000252553	.	227643	0.02
chr2_214003351_214003502	0.17	IKZF2	IKAROS family zinc finger 2 (Helios)	9927	0.3
chr17_1478282_1478467	0.17	PITPNA	phosphatidylinositol transfer protein, alpha	12264	0.11
chr12_128113659_128113866	0.17	ENSG00000199584	.	9770	0.33
chr2_113958350_113958501	0.17	PSD4	pleckstrin and Sec7 domain containing 4	4568	0.16
chr3_58359199_58359350	0.17	PXK	PX domain containing serine/threonine kinase	22127	0.17
chr4_169553357_169553551	0.17	PALLD	palladin, cytoskeletal associated protein	686	0.73
chr7_37349873_37350077	0.17	ELMO1	engulfment and cell motility 1	32392	0.18
chr1_120191467_120191618	0.17	ZNF697	zinc finger protein 697	1146	0.52
chr4_85553592_85553743	0.17	CDS1	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	49535	0.15
chr2_118855601_118855752	0.17	INSIG2	insulin induced gene 2	9626	0.24
chrX_2507647_2507798	0.17	CD99P1	CD99 molecule pseudogene 1	19734	0.22
chrY_2457647_2457798	0.17	ENSG00000251841	.	195068	0.03
chr21_41095530_41095681	0.17	IGSF5	immunoglobulin superfamily, member 5	21729	0.21
chr11_12132484_12132785	0.17	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	496	0.87
chr1_44792092_44792243	0.17	ERI3	ERI1 exoribonuclease family member 3	3452	0.22
chr19_19514440_19514591	0.17	CTB-184G21.3		1103	0.38
chr11_102183446_102183978	0.17	ENSG00000212466	.	741	0.64
chr21_36771263_36771477	0.16	ENSG00000211590	.	321643	0.01
chr2_175708769_175708920	0.16	CHN1	chimerin 1	2289	0.38
chr5_95564073_95564224	0.16	ENSG00000206997	.	18217	0.26
chr14_51242372_51242693	0.16	NIN	ninein (GSK3B interacting protein)	9019	0.17
chr3_145437289_145437440	0.16	RP11-274H2.5		342102	0.01
chr3_43735748_43735899	0.16	ANO10	anoctamin 10	2737	0.3
chr8_102898890_102899041	0.16	ENSG00000238372	.	39377	0.2
chr17_5268697_5268848	0.16	RP11-420A6.2		6149	0.15
chr4_8702215_8702366	0.16	CPZ	carboxypeptidase Z	98593	0.07
chr9_4137636_4137913	0.16	GLIS3	GLIS family zinc finger 3	7419	0.28
chr21_18884161_18884312	0.16	CXADR	coxsackie virus and adenovirus receptor	464	0.77
chr15_71391266_71391417	0.16	THSD4	thrombospondin, type I, domain containing 4	2050	0.37
chr2_52029885_52030036	0.16	ENSG00000222692	.	367604	0.01
chr6_39772789_39772940	0.16	DAAM2	dishevelled associated activator of morphogenesis 2	12070	0.26
chr5_19885020_19885171	0.16	CDH18	cadherin 18, type 2	1286	0.64
chr1_230223080_230223231	0.16	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	20137	0.23
chr3_15482302_15482608	0.16	EAF1-AS1	EAF1 antisense RNA 1	354	0.48
chr20_52214556_52214707	0.16	ZNF217	zinc finger protein 217	4253	0.23
chr9_78870959_78871162	0.16	PCSK5	proprotein convertase subtilisin/kexin type 5	67505	0.13
chr5_32991481_32991632	0.15	AC026703.1		202611	0.03
chr13_19683905_19684056	0.15	ENSG00000252287	.	21353	0.16
chr5_95457320_95457471	0.15	ENSG00000207578	.	42553	0.17
chr1_181455866_181456017	0.15	CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	3060	0.4
chr4_38754112_38754445	0.15	ENSG00000222230	.	6235	0.19
chr20_49110116_49110267	0.15	PTPN1	protein tyrosine phosphatase, non-receptor type 1	16700	0.18
chr7_101457714_101458422	0.15	CUX1	cut-like homeobox 1	891	0.64
chr15_73926288_73926474	0.15	NPTN	neuroplastin	94	0.98
chr5_142217391_142217542	0.15	ARHGAP26-AS1	ARHGAP26 antisense RNA 1	31009	0.21
chr1_116222239_116222390	0.15	VANGL1	VANGL planar cell polarity protein 1	28291	0.19
chr18_24083489_24083640	0.15	KCTD1	potassium channel tetramerization domain containing 1	43399	0.17
chr7_116416437_116416588	0.15	MET	met proto-oncogene	717	0.73
chr7_27190645_27191214	0.15	HOXA-AS3	HOXA cluster antisense RNA 3	1258	0.18
chr8_27983413_27983564	0.15	ELP3	elongator acetyltransferase complex subunit 3	32524	0.17
chr14_69015576_69015827	0.15	CTD-2325P2.4		79461	0.1
chr5_142775880_142776681	0.15	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	4137	0.35
chr22_22204157_22204308	0.15	MAPK1	mitogen-activated protein kinase 1	17498	0.14
chr21_15922641_15922820	0.15	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	4066	0.28
chr4_160248318_160248469	0.15	RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	4385	0.29
chr10_97154342_97154493	0.15	SORBS1	sorbin and SH3 domain containing 1	21035	0.25
chr12_62115825_62115976	0.15	FAM19A2	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	105114	0.08
chr5_94384750_94385033	0.15	MCTP1	multiple C2 domains, transmembrane 1	31700	0.22
chr18_61447047_61447198	0.14	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	1911	0.39
chr2_206543328_206543479	0.14	NRP2	neuropilin 2	3821	0.34
chr1_172290167_172290671	0.14	ENSG00000252354	.	26864	0.17
chr4_35782309_35782460	0.14	ENSG00000206665	.	284864	0.01
chr1_189628853_189629004	0.14	ENSG00000252553	.	6458	0.35
chr3_187467694_187467973	0.14	BCL6	B-cell CLL/lymphoma 6	4318	0.26
chr12_69731656_69731807	0.14	LYZ	lysozyme	10390	0.17
chr16_87522864_87523015	0.14	ZCCHC14	zinc finger, CCHC domain containing 14	2712	0.29
chr11_119089001_119089152	0.14	CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase	12324	0.1
chr5_44620644_44620795	0.14	ENSG00000263556	.	95573	0.09
chr4_157873991_157874142	0.14	PDGFC	platelet derived growth factor C	17989	0.21
chr2_161331149_161331300	0.14	RBMS1	RNA binding motif, single stranded interacting protein 1	18805	0.24
chr4_157860820_157861106	0.14	PDGFC	platelet derived growth factor C	31092	0.19
chr16_46655371_46655551	0.14	SHCBP1	SHC SH2-domain binding protein 1	77	0.97
chr10_134513988_134514364	0.14	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	65152	0.12
chr12_59434723_59435248	0.14	RP11-150C16.1		120565	0.06
chr10_69865396_69865547	0.14	MYPN	myopalladin	441	0.84
chr1_28575788_28575939	0.14	RP5-1092A3.4		7899	0.11
chr11_104838069_104839428	0.14	CASP4	caspase 4, apoptosis-related cysteine peptidase	1345	0.45
chr9_111207460_111207611	0.14	ENSG00000222512	.	86326	0.11
chr1_98816414_98816565	0.14	ENSG00000221777	.	22452	0.29
chr8_93887341_93887492	0.14	ENSG00000248858	.	2449	0.28
chr18_61535025_61535176	0.14	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	3826	0.24
chr17_32078540_32078804	0.14	ENSG00000221699	.	122805	0.05
chr2_26100038_26101197	0.14	ASXL2	additional sex combs like 2 (Drosophila)	718	0.76
chr2_207987855_207988006	0.14	KLF7-IT1	KLF7 intronic transcript 1 (non-protein coding)	1162	0.49
chr15_64391220_64391371	0.14	SNX1	sorting nexin 1	3070	0.19
chr5_80210177_80210328	0.14	CTC-459I6.1		38547	0.18
chr9_102849500_102849651	0.13	ERP44	endoplasmic reticulum protein 44	11747	0.18
chr12_85768780_85768931	0.13	ALX1	ALX homeobox 1	94970	0.09
chr6_136256925_136257180	0.13	ENSG00000238921	.	21159	0.21
chr13_71667523_71667674	0.13	ENSG00000202433	.	634002	0.0
chr12_22435490_22435710	0.13	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	33620	0.22
chr5_129840711_129840862	0.13	ENSG00000252514	.	118413	0.07
chr4_116464375_116464526	0.13	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	429418	0.01
chr9_99391498_99391649	0.13	CDC14B	cell division cycle 14B	9461	0.24
chr11_37129867_37130018	0.13	RAG2	recombination activating gene 2	510156	0.0
chr5_67586145_67586431	0.13	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	177	0.97
chr1_197730742_197731002	0.13	RP11-448G4.4		4423	0.25
chr7_82070146_82070432	0.13	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	2742	0.43
chr20_24270294_24270445	0.13	ENSG00000200231	.	52478	0.18
chr19_11466484_11467017	0.13	DKFZP761J1410	Lipid phosphate phosphatase-related protein type 2	576	0.52
chr4_181237914_181238065	0.13	NA	NA	> 10⁶	NA
chr21_18785623_18785774	0.13	ENSG00000252462	.	18167	0.18
chr1_220527416_220527567	0.13	AC096644.1	Uncharacterized protein	80532	0.09
chr20_50722770_50722921	0.13	ZFP64	ZFP64 zinc finger protein	662	0.82
chr14_93720610_93720761	0.13	UBR7	ubiquitin protein ligase E3 component n-recognin 7 (putative)	35658	0.11
chr22_24917713_24917864	0.13	AP000355.2		5312	0.15
chr6_108886554_108887901	0.13	FOXO3	forkhead box O3	5158	0.32
chr12_5427929_5428080	0.13	NTF3	neurotrophin 3	113275	0.07
chr15_31734664_31735087	0.13	KLF13	Kruppel-like factor 13	76518	0.12
chr9_21548772_21548928	0.13	MIR31HG	MIR31 host gene (non-protein coding)	10818	0.17
chr10_91811914_91812065	0.13	ENSG00000222451	.	111728	0.07
chr4_177931083_177931234	0.13	ENSG00000222859	.	171438	0.03
chr3_151033417_151033568	0.13	GPR87	G protein-coupled receptor 87	1248	0.43
chr3_42191892_42192043	0.13	TRAK1	trafficking protein, kinesin binding 1	1240	0.57
chr18_59666248_59666399	0.13	RNF152	ring finger protein 152	104859	0.07
chr18_3351537_3351688	0.13	TGIF1	TGFB-induced factor homeobox 1	59994	0.1
chr10_105609571_105609851	0.13	SH3PXD2A	SH3 and PX domains 2A	5453	0.22
chr6_98415844_98415995	0.13	ENSG00000238367	.	56488	0.18
chr20_49272065_49272493	0.13	RP4-530I15.6		2540	0.24
chr6_72970806_72970957	0.13	RIMS1	regulating synaptic membrane exocytosis 1	8387	0.27
chr9_21677527_21678485	0.13	ENSG00000244230	.	21307	0.21
chr5_153827010_153827219	0.13	SAP30L	SAP30-like	1009	0.44
chr4_187686004_187686155	0.13	FAT1	FAT atypical cadherin 1	38203	0.2
chr9_286081_286232	0.13	DOCK8	dedicator of cytokinesis 8	13086	0.19
chr2_206678700_206678851	0.13	AC007362.3		50045	0.15
chr3_45986008_45986159	0.13	CXCR6	chemokine (C-X-C motif) receptor 6	428	0.8
chr10_27771901_27772052	0.13	RAB18	RAB18, member RAS oncogene family	21221	0.22
chr10_111794329_111794480	0.13	ADD3	adducin 3 (gamma)	26682	0.18
chr7_74077316_74077467	0.12	GTF2I	general transcription factor IIi	5034	0.25
chr17_41281323_41281529	0.12	NBR2	neighbor of BRCA1 gene 2 (non-protein coding)	1799	0.26
chr9_26262415_26262566	0.12	ENSG00000266429	.	351633	0.01
chr2_195590152_195590303	0.12	ENSG00000252517	.	61329	0.16
chr4_48701192_48701343	0.12	FRYL	FRY-like	18079	0.24
chr4_180046351_180046502	0.12	ENSG00000212191	.	439316	0.01

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032808	lacrimal gland development(GO:0032808)
0.1	0.2	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.0	0.1	GO:0060044	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.0	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0051140	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.1	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0060430	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.0	GO:0030540	female genitalia development(GO:0030540)
0.0	0.1	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.0	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:2000794	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions