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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for MSX2

Z-value: 0.61

Motif logo

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Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
MSX2
ENSG00000120149.7 msh homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr5_174150731_174150989MSX26760.7852570.674.7e-02Click!
chr5_174148598_174148749MSX228630.3552180.674.7e-02Click!
chr5_174152116_174152407MSX26560.7927780.656.0e-02Click!
chr5_174151487_174151917MSX2970.9803110.646.2e-02Click!
chr5_174147841_174148039MSX235960.3246660.627.2e-02Click!

Activity of the MSX2 motif across conditions

Conditions sorted by the z-value of the MSX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_69454777_69455129 0.39 CCND1
 cyclin D1
 902
 0.63
chr10_96161850_96162001 0.39 TBC1D12
 TBC1 domain family, member 12
 336
 0.91
chr8_37350646_37351319 0.39 RP11-150O12.6
23557
 0.24
chr10_52750817_52751095 0.36 PRKG1
 protein kinase, cGMP-dependent, type I
 11
 0.99
chr10_112290027_112290231 0.36 DUSP5
 dual specificity phosphatase 5
 32533
 0.13
chr13_77466816_77466967 0.36 KCTD12
 potassium channel tetramerization domain containing 12
 6351
 0.21
chr5_96000350_96000501 0.35 CAST
 calpastatin
 1668
 0.37
chr2_23603304_23603524 0.34 KLHL29
 kelch-like family member 29
 4674
 0.35
chr6_41472777_41473161 0.34 RP11-328M4.2
40843
 0.13
chr13_76336103_76336254 0.34 LMO7
 LIM domain 7
 1381
 0.54
chr5_95294796_95295032 0.33 ELL2
 elongation factor, RNA polymerase II, 2
 2638
 0.26
chr1_79043181_79043547 0.32 IFI44L
 interferon-induced protein 44-like
 42243
 0.17
chr2_101728731_101728882 0.30 ENSG00000265860
 .
 18775
 0.19
chr11_56181990_56182141 0.30 OR5R1
 olfactory receptor, family 5, subfamily R, member 1
 3643
 0.18
chr10_6763782_6764322 0.30 PRKCQ
 protein kinase C, theta
 141789
 0.05
chr1_30417491_30417642 0.29 ENSG00000222787
 .
 59817
 0.17
chr18_55888880_55889307 0.28 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
 290
 0.93
chr12_56917781_56918152 0.28 RBMS2
 RNA binding motif, single stranded interacting protein 2
 2183
 0.23
chr9_72745702_72745853 0.27 MAMDC2-AS1
 MAMDC2 antisense RNA 1
 17001
 0.22
chr14_43058348_43058499 0.27 CTD-2307P3.1
226237
 0.02
chr2_163171316_163171467 0.26 IFIH1
 interferon induced with helicase C domain 1
 3803
 0.25
chr17_41668751_41668949 0.26 ETV4
 ets variant 4
 11862
 0.16
chr7_82070146_82070432 0.26 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 2742
 0.43
chr3_113462542_113462739 0.25 NAA50
 N(alpha)-acetyltransferase 50, NatE catalytic subunit
 2001
 0.3
chr11_101917896_101918104 0.24 C11orf70
 chromosome 11 open reading frame 70
 174
 0.94
chr2_188418561_188419245 0.24 AC007319.1
27
 0.69
chr9_125836272_125836843 0.24 MIR600HG
 MIR600 host gene (non-protein coding)
 36887
 0.13
chr6_28415243_28415394 0.23 ZSCAN23
 zinc finger and SCAN domain containing 23
 4074
 0.2
chr11_122049732_122050124 0.23 ENSG00000207994
 .
 26912
 0.16
chr18_6884956_6885107 0.23 RP11-146G7.2
10008
 0.19
chr1_160176529_160176680 0.23 PEA15
 phosphoprotein enriched in astrocytes 15
 1393
 0.2
chr4_81228803_81229090 0.23 C4orf22
 chromosome 4 open reading frame 22
 27928
 0.2
chr16_84652917_84653068 0.22 COTL1
 coactosin-like 1 (Dictyostelium)
 1309
 0.42
chr7_70201396_70202343 0.22 AUTS2
 autism susceptibility candidate 2
 7744
 0.34
chr20_36040358_36040543 0.22 SRC
 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
 27897
 0.21
chr1_54964656_54964938 0.21 ENSG00000265404
 .
 5544
 0.2
chr1_210074416_210074567 0.21 SYT14
 synaptotagmin XIV
 37047
 0.16
chr10_119303944_119304573 0.21 EMX2OS
 EMX2 opposite strand/antisense RNA
 321
 0.88
chr9_91349159_91349310 0.21 ENSG00000265873
 .
 11586
 0.3
chr10_119302142_119302346 0.21 EMX2
 empty spiracles homeobox 2
 265
 0.64
chr9_124799161_124799312 0.21 TTLL11
 tubulin tyrosine ligase-like family, member 11
 56649
 0.12
chr20_61884855_61885070 0.21 NKAIN4
 Na+/K+ transporting ATPase interacting 4
 173
 0.91
chr1_8084803_8084954 0.21 ERRFI1
 ERBB receptor feedback inhibitor 1
 1465
 0.44
chr10_126198812_126198963 0.21 LHPP
 phospholysine phosphohistidine inorganic pyrophosphate phosphatase
 48475
 0.13
chr11_27491638_27491912 0.21 RP11-159H22.2
1501
 0.32
chr11_120271835_120271998 0.20 ARHGEF12
 Rho guanine nucleotide exchange factor (GEF) 12
 15913
 0.2
chr17_48588630_48588781 0.20 MYCBPAP
 MYCBP associated protein
 2722
 0.15
chr5_168323546_168323697 0.20 CTB-174D11.2
96384
 0.07
chr1_198413244_198413395 0.20 ATP6V1G3
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
 96485
 0.09
chr7_157476784_157476935 0.20 AC006003.3
56289
 0.13
chr2_174267051_174267205 0.20 CDCA7
 cell division cycle associated 7
 47528
 0.19
chr1_201464859_201465010 0.20 CSRP1
 cysteine and glycine-rich protein 1
 767
 0.61
chr7_45961953_45962825 0.20 IGFBP3
 insulin-like growth factor binding protein 3
 916
 0.6
chr4_39639074_39639261 0.20 SMIM14
 small integral membrane protein 14
 1346
 0.42
chr1_56106402_56106768 0.20 ENSG00000272051
 .
 155940
 0.04
chr2_8135764_8135915 0.20 ENSG00000221255
 .
 418867
 0.01
chr2_216299709_216300678 0.19 FN1
 fibronectin 1
 597
 0.55
chr4_26344236_26344574 0.19 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 357
 0.93
chr10_30237773_30238416 0.19 KIAA1462
 KIAA1462
 110359
 0.07
chr8_102513775_102514058 0.19 GRHL2
 grainyhead-like 2 (Drosophila)
 8930
 0.22
chr9_89952337_89952906 0.19 ENSG00000212421
 .
 77256
 0.11
chr5_154465051_154465202 0.18 ENSG00000221131
 .
 60766
 0.13
chr9_133722351_133722531 0.18 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 11988
 0.21
chr3_114598031_114598292 0.18 ZBTB20
 zinc finger and BTB domain containing 20
 120043
 0.06
chr4_57984994_57985389 0.18 IGFBP7
 insulin-like growth factor binding protein 7
 8640
 0.18
chr20_52352609_52352999 0.18 ENSG00000238468
 .
 67507
 0.12
chr3_110132535_110132686 0.18 ENSG00000221206
 .
 138202
 0.05
chr10_114552420_114552740 0.18 RP11-57H14.4
30669
 0.21
chr3_116583114_116583333 0.18 ENSG00000265433
 .
 14009
 0.25
chr13_27190840_27190991 0.18 WASF3-AS1
 WASF3 antisense RNA 1
 24586
 0.23
chr5_3597777_3597928 0.18 IRX1
 iroquois homeobox 1
 1684
 0.41
chr10_15762100_15762293 0.18 ITGA8
 integrin, alpha 8
 72
 0.99
chr2_119188658_119188833 0.18 INSIG2
 insulin induced gene 2
 342695
 0.01
chr3_196080166_196080317 0.18 ENSG00000212146
 .
 11655
 0.1
chr16_2315946_2316097 0.18 RNPS1
 RNA binding protein S1, serine-rich domain
 503
 0.49
chr6_73262911_73263125 0.18 KCNQ5
 potassium voltage-gated channel, KQT-like subfamily, member 5
 68502
 0.12
chr16_54968352_54968503 0.18 IRX5
 iroquois homeobox 5
 2443
 0.45
chr6_15505200_15505483 0.17 DTNBP1
 dystrobrevin binding protein 1
 43252
 0.19
chr1_182811531_182811809 0.17 DHX9
 DEAH (Asp-Glu-Ala-His) box helicase 9
 3166
 0.28
chr5_80444015_80444393 0.17 CTD-2193P3.2
33533
 0.2
chr1_210424215_210424840 0.17 SERTAD4-AS1
 SERTAD4 antisense RNA 1
 17135
 0.21
chr17_12569246_12569498 0.17 MYOCD
 myocardin
 66
 0.98
chr9_107688440_107688591 0.17 RP11-217B7.2
1319
 0.43
chr3_185446261_185446412 0.17 C3orf65
 chromosome 3 open reading frame 65
 15256
 0.21
chr2_511397_511548 0.17 TMEM18
 transmembrane protein 18
 164303
 0.03
chr1_161932087_161932899 0.17 OLFML2B
 olfactomedin-like 2B
 22529
 0.22
chr12_67669324_67669475 0.17 CAND1
 cullin-associated and neddylation-dissociated 1
 5718
 0.35
chr16_73092840_73093092 0.17 ZFHX3
 zinc finger homeobox 3
 631
 0.78
chr10_85954003_85954712 0.17 CDHR1
 cadherin-related family member 1
 53
 0.97
chr8_23202144_23202555 0.17 ENSG00000253837
 .
 8628
 0.17
chr14_36409550_36409712 0.17 RP11-116N8.1
42443
 0.16
chr12_66220556_66220804 0.17 HMGA2
 high mobility group AT-hook 2
 1777
 0.39
chr2_58272799_58272950 0.17 VRK2
 vaccinia related kinase 2
 855
 0.7
chr14_81789696_81789847 0.17 STON2
 stonin 2
 46494
 0.18
chr1_154840943_154841324 0.17 KCNN3
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
 338
 0.86
chr15_33154166_33154394 0.17 FMN1
 formin 1
 26175
 0.19
chr3_169189329_169189480 0.17 RP11-641D5.2
23749
 0.25
chr22_43400050_43400213 0.16 PACSIN2
 protein kinase C and casein kinase substrate in neurons 2
 1685
 0.39
chr7_14598843_14598994 0.16 ENSG00000221428
 .
 216113
 0.02
chr3_55062884_55063062 0.16 LRTM1
 leucine-rich repeats and transmembrane domains 1
 61858
 0.15
chr1_198393639_198393891 0.16 ATP6V1G3
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
 116039
 0.07
chr9_3794141_3794308 0.16 RP11-252M18.3
81360
 0.1
chr15_33135515_33135666 0.16 FMN1
 formin 1
 44865
 0.14
chr10_33248509_33248959 0.16 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 1574
 0.52
chr2_200446222_200446758 0.16 SATB2
 SATB homeobox 2
 110501
 0.07
chr1_172327450_172327703 0.16 ENSG00000206684
 .
 8104
 0.18
chr4_83810146_83810528 0.16 SEC31A
 SEC31 homolog A (S. cerevisiae)
 1834
 0.28
chr1_16007655_16007806 0.16 PLEKHM2
 pleckstrin homology domain containing, family M (with RUN domain) member 2
 3097
 0.14
chr22_46476561_46476775 0.15 FLJ27365
 hsa-mir-4763
 476
 0.66
chr18_20612011_20612377 0.15 ENSG00000223023
 .
 7635
 0.17
chr6_33589286_33590289 0.15 ITPR3
 inositol 1,4,5-trisphosphate receptor, type 3
 626
 0.65
chr11_79793585_79793736 0.15 ENSG00000221551
 .
 390237
 0.01
chr5_38807697_38807893 0.15 RP11-122C5.3
24113
 0.22
chr10_63596511_63596662 0.15 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 64473
 0.13
chrX_78002931_78003376 0.15 LPAR4
 lysophosphatidic acid receptor 4
 72
 0.99
chr5_170763491_170764141 0.15 ENSG00000265740
 .
 22305
 0.14
chr2_132120817_132121347 0.15 FAR2P4
 fatty acyl CoA reductase 2 pseudogene 4
 66666
 0.1
chr12_54418548_54418910 0.15 HOXC6
 homeobox C6
 3413
 0.09
chr11_12849556_12849989 0.15 RP11-47J17.3
4558
 0.23
chr4_176622049_176622200 0.15 GPM6A
 glycoprotein M6A
 86414
 0.1
chr7_121944638_121944844 0.15 FEZF1
 FEZ family zinc finger 1
 182
 0.61
chr10_119132010_119132432 0.15 PDZD8
 PDZ domain containing 8
 2757
 0.3
chr15_47476270_47477144 0.15 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 409
 0.87
chr21_17909068_17909746 0.15 ENSG00000207638
 .
 2002
 0.33
chr3_188841418_188841569 0.15 TPRG1
 tumor protein p63 regulated 1
 23583
 0.27
chr6_106246069_106246220 0.15 ENSG00000200198
 .
 106104
 0.08
chr12_115135696_115136278 0.15 TBX3
 T-box 3
 14018
 0.21
chr16_11655655_11655806 0.14 LITAF
 lipopolysaccharide-induced TNF factor
 24499
 0.15
chr6_28442401_28443147 0.14 ZSCAN23
 zinc finger and SCAN domain containing 23
 31530
 0.13
chr18_53253101_53253291 0.14 TCF4
 transcription factor 4
 1
 0.99
chr14_74724486_74725063 0.14 VSX2
 visual system homeobox 2
 18599
 0.14
chr7_146980619_146980770 0.14 ENSG00000221442
 .
 94519
 0.09
chr3_192288894_192289136 0.14 ENSG00000238902
 .
 37114
 0.17
chr2_71772491_71772642 0.14 DYSF
 dysferlin
 78734
 0.11
chr17_39874099_39874250 0.14 ENSG00000201920
 .
 232
 0.86
chr10_74436092_74436294 0.14 MCU
 mitochondrial calcium uniporter
 15696
 0.15
chr4_66301222_66301373 0.14 EPHA5
 EPH receptor A5
 234356
 0.02
chr3_168825494_168825645 0.14 MECOM
 MDS1 and EVI1 complex locus
 20253
 0.29
chr15_101899572_101899723 0.14 PCSK6
 proprotein convertase subtilisin/kexin type 6
 6820
 0.2
chr1_120255525_120255935 0.14 PHGDH
 phosphoglycerate dehydrogenase
 1220
 0.51
chr5_82771308_82771459 0.14 VCAN
 versican
 3639
 0.35
chr13_60348574_60349034 0.14 DIAPH3-AS1
 DIAPH3 antisense RNA 1
 238081
 0.02
chr3_114790766_114791082 0.14 ZBTB20
 zinc finger and BTB domain containing 20
 702
 0.82
chr7_19141522_19141673 0.14 AC003986.6
10500
 0.16
chr1_112604147_112604298 0.14 KCND3
 potassium voltage-gated channel, Shal-related subfamily, member 3
 72445
 0.11
chr6_18028807_18028958 0.13 KIF13A
 kinesin family member 13A
 41028
 0.18
chr22_36232810_36232961 0.13 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 3380
 0.35
chr3_27367755_27367906 0.13 NEK10
 NIMA-related kinase 10
 34782
 0.16
chr10_6836277_6836922 0.13 PRKCQ
 protein kinase C, theta
 214336
 0.02
chr3_25472946_25473178 0.13 RARB
 retinoic acid receptor, beta
 3260
 0.35
chr3_100923421_100923572 0.13 ENSG00000238312
 .
 2820
 0.37
chr14_21564786_21565064 0.13 ZNF219
 zinc finger protein 219
 1874
 0.17
chr12_120246427_120246712 0.13 CIT
 citron (rho-interacting, serine/threonine kinase 21)
 5382
 0.27
chr1_231997217_231997368 0.13 DISC1-IT1
 DISC1 intronic transcript 1 (non-protein coding)
 64288
 0.14
chr21_30502420_30502571 0.13 MAP3K7CL
 MAP3K7 C-terminal like
 311
 0.86
chr11_128811477_128811628 0.13 TP53AIP1
 tumor protein p53 regulated apoptosis inducing protein 1
 1270
 0.42
chr11_111667514_111667665 0.13 PPP2R1B
 protein phosphatase 2, regulatory subunit A, beta
 30438
 0.12
chr1_149378983_149379172 0.13 FCGR1C
 Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene
 9720
 0.13
chr4_14169430_14169581 0.13 ENSG00000252092
 .
 509254
 0.0
chr5_147836900_147837051 0.13 CTD-2283N19.1
26605
 0.18
chr5_164797749_164797900 0.13 ENSG00000252794
 .
 238622
 0.02
chr1_70509689_70509840 0.13 RP11-181B18.1
12859
 0.27
chr11_34648519_34648670 0.13 EHF
 ets homologous factor
 2771
 0.38
chr18_31157392_31158104 0.13 ASXL3
 additional sex combs like 3 (Drosophila)
 848
 0.76
chr8_99961176_99961327 0.13 OSR2
 odd-skipped related transciption factor 2
 631
 0.7
chr14_89507425_89507846 0.13 FOXN3
 forkhead box N3
 139453
 0.05
chr13_33858125_33858279 0.13 STARD13
 StAR-related lipid transfer (START) domain containing 13
 1690
 0.4
chr12_80838762_80838913 0.13 PTPRQ
 protein tyrosine phosphatase, receptor type, Q
 711
 0.78
chr7_102532238_102532586 0.13 LRRC17
 leucine rich repeat containing 17
 21026
 0.16
chr19_34113333_34113659 0.13 CHST8
 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
 619
 0.82
chr22_46471692_46472277 0.13 FLJ27365
 hsa-mir-4763
 4208
 0.11
chr10_126846587_126846738 0.13 CTBP2
 C-terminal binding protein 2
 623
 0.83
chr10_104306894_104307045 0.13 ENSG00000242311
 .
 21247
 0.12
chr7_5620896_5621047 0.13 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 11468
 0.14
chr9_78870959_78871162 0.13 PCSK5
 proprotein convertase subtilisin/kexin type 5
 67505
 0.13
chr17_75567549_75568025 0.13 SEPT9
 septin 9
 89792
 0.07
chr14_99720527_99720678 0.13 AL109767.1
8683
 0.22
chr1_151960835_151961083 0.13 S100A10
 S100 calcium binding protein A10
 4095
 0.17
chr8_95447406_95448205 0.13 FSBP
 fibrinogen silencer binding protein
 1365
 0.47
chr17_39065845_39065996 0.12 AC004231.2
11762
 0.09
chr18_59619337_59619488 0.12 RNF152
 ring finger protein 152
 57948
 0.16
chr10_95224937_95225088 0.12 MYOF
 myoferlin
 16939
 0.19
chr13_95952806_95953583 0.12 ABCC4
 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
 395
 0.86
chr5_58055562_58056142 0.12 RP11-479O16.1
24754
 0.24
chr15_50648671_50648965 0.12 ENSG00000244879
 .
 150
 0.91
chr22_46483352_46483503 0.12 FLJ27365
 hsa-mir-4763
 1544
 0.22
chr14_54423071_54423266 0.12 BMP4
 bone morphogenetic protein 4
 361
 0.91
chr20_14317138_14317687 0.12 FLRT3
 fibronectin leucine rich transmembrane protein 3
 842
 0.69
chr7_5637609_5637772 0.12 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 3373
 0.21
chr5_158036732_158037177 0.12 CTD-2363C16.1
373060
 0.01
chr7_107640774_107640963 0.12 ENSG00000238297
 .
 441
 0.76
chr14_22330961_22331112 0.12 ENSG00000222776
 .
 82251
 0.1
chr14_103541034_103541185 0.12 CDC42BPB
 CDC42 binding protein kinase beta (DMPK-like)
 17310
 0.15
chr19_1745649_1745800 0.12 ONECUT3
 one cut homeobox 3
 6648
 0.14
chr2_48675517_48675668 0.12 PPP1R21
 protein phosphatase 1, regulatory subunit 21
 7324
 0.23
chr15_96878465_96878729 0.12 ENSG00000222651
 .
 2107
 0.24
chr17_78194664_78195096 0.12 SGSH
 N-sulfoglucosamine sulfohydrolase
 158
 0.63
chr1_200865204_200865355 0.12 C1orf106
 chromosome 1 open reading frame 106
 1330
 0.42
chr1_46714502_46714653 0.12 RAD54L
 RAD54-like (S. cerevisiae)
 1136
 0.42
chr17_11640186_11640337 0.12 ENSG00000263623
 .
 4520
 0.33

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:0070141 response to UV-A(GO:0070141)
0.1 0.2 GO:0021542 dentate gyrus development(GO:0021542)
0.1 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.2 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.0 GO:0060677 ureteric bud elongation(GO:0060677)
0.0 0.0 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.0 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.2 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.1 GO:0000768 syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0051531 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0042640 anagen(GO:0042640)
0.0 0.1 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0002076 osteoblast development(GO:0002076)
0.0 0.0 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:2000144 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.4 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.0 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.0 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.2 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions