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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MSX2

Z-value: 0.61

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Transcription factors associated with MSX2

Gene Symbol	Gene ID	Gene Info
MSX2 Ensembl NCBI GeneCards UniProt	ENSG00000120149.7	MSX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MSX2	chr5_174150731_174150989	676	0.785257	0.67	4.7e-02	Click!
MSX2	chr5_174148598_174148749	2863	0.355218	0.67	4.7e-02	Click!
MSX2	chr5_174152116_174152407	656	0.792778	0.65	6.0e-02	Click!
MSX2	chr5_174151487_174151917	97	0.980311	0.64	6.2e-02	Click!
MSX2	chr5_174147841_174148039	3596	0.324666	0.62	7.2e-02	Click!

Activity of the MSX2 motif across conditions

Conditions sorted by the z-value of the MSX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_69454777_69455129	0.39	CCND1	cyclin D1	902	0.63
chr10_96161850_96162001	0.39	TBC1D12	TBC1 domain family, member 12	336	0.91
chr8_37350646_37351319	0.39	RP11-150O12.6		23557	0.24
chr10_52750817_52751095	0.36	PRKG1	protein kinase, cGMP-dependent, type I	11	0.99
chr10_112290027_112290231	0.36	DUSP5	dual specificity phosphatase 5	32533	0.13
chr13_77466816_77466967	0.36	KCTD12	potassium channel tetramerization domain containing 12	6351	0.21
chr5_96000350_96000501	0.35	CAST	calpastatin	1668	0.37
chr2_23603304_23603524	0.34	KLHL29	kelch-like family member 29	4674	0.35
chr6_41472777_41473161	0.34	RP11-328M4.2		40843	0.13
chr13_76336103_76336254	0.34	LMO7	LIM domain 7	1381	0.54
chr5_95294796_95295032	0.33	ELL2	elongation factor, RNA polymerase II, 2	2638	0.26
chr1_79043181_79043547	0.32	IFI44L	interferon-induced protein 44-like	42243	0.17
chr2_101728731_101728882	0.30	ENSG00000265860	.	18775	0.19
chr11_56181990_56182141	0.30	OR5R1	olfactory receptor, family 5, subfamily R, member 1	3643	0.18
chr10_6763782_6764322	0.30	PRKCQ	protein kinase C, theta	141789	0.05
chr1_30417491_30417642	0.29	ENSG00000222787	.	59817	0.17
chr18_55888880_55889307	0.28	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	290	0.93
chr12_56917781_56918152	0.28	RBMS2	RNA binding motif, single stranded interacting protein 2	2183	0.23
chr9_72745702_72745853	0.27	MAMDC2-AS1	MAMDC2 antisense RNA 1	17001	0.22
chr14_43058348_43058499	0.27	CTD-2307P3.1		226237	0.02
chr2_163171316_163171467	0.26	IFIH1	interferon induced with helicase C domain 1	3803	0.25
chr17_41668751_41668949	0.26	ETV4	ets variant 4	11862	0.16
chr7_82070146_82070432	0.26	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	2742	0.43
chr3_113462542_113462739	0.25	NAA50	N(alpha)-acetyltransferase 50, NatE catalytic subunit	2001	0.3
chr11_101917896_101918104	0.24	C11orf70	chromosome 11 open reading frame 70	174	0.94
chr2_188418561_188419245	0.24	AC007319.1		27	0.69
chr9_125836272_125836843	0.24	MIR600HG	MIR600 host gene (non-protein coding)	36887	0.13
chr6_28415243_28415394	0.23	ZSCAN23	zinc finger and SCAN domain containing 23	4074	0.2
chr11_122049732_122050124	0.23	ENSG00000207994	.	26912	0.16
chr18_6884956_6885107	0.23	RP11-146G7.2		10008	0.19
chr1_160176529_160176680	0.23	PEA15	phosphoprotein enriched in astrocytes 15	1393	0.2
chr4_81228803_81229090	0.23	C4orf22	chromosome 4 open reading frame 22	27928	0.2
chr16_84652917_84653068	0.22	COTL1	coactosin-like 1 (Dictyostelium)	1309	0.42
chr7_70201396_70202343	0.22	AUTS2	autism susceptibility candidate 2	7744	0.34
chr20_36040358_36040543	0.22	SRC	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	27897	0.21
chr1_54964656_54964938	0.21	ENSG00000265404	.	5544	0.2
chr1_210074416_210074567	0.21	SYT14	synaptotagmin XIV	37047	0.16
chr10_119303944_119304573	0.21	EMX2OS	EMX2 opposite strand/antisense RNA	321	0.88
chr9_91349159_91349310	0.21	ENSG00000265873	.	11586	0.3
chr10_119302142_119302346	0.21	EMX2	empty spiracles homeobox 2	265	0.64
chr9_124799161_124799312	0.21	TTLL11	tubulin tyrosine ligase-like family, member 11	56649	0.12
chr20_61884855_61885070	0.21	NKAIN4	Na+/K+ transporting ATPase interacting 4	173	0.91
chr1_8084803_8084954	0.21	ERRFI1	ERBB receptor feedback inhibitor 1	1465	0.44
chr10_126198812_126198963	0.21	LHPP	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	48475	0.13
chr11_27491638_27491912	0.21	RP11-159H22.2		1501	0.32
chr11_120271835_120271998	0.20	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	15913	0.2
chr17_48588630_48588781	0.20	MYCBPAP	MYCBP associated protein	2722	0.15
chr5_168323546_168323697	0.20	CTB-174D11.2		96384	0.07
chr1_198413244_198413395	0.20	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	96485	0.09
chr7_157476784_157476935	0.20	AC006003.3		56289	0.13
chr2_174267051_174267205	0.20	CDCA7	cell division cycle associated 7	47528	0.19
chr1_201464859_201465010	0.20	CSRP1	cysteine and glycine-rich protein 1	767	0.61
chr7_45961953_45962825	0.20	IGFBP3	insulin-like growth factor binding protein 3	916	0.6
chr4_39639074_39639261	0.20	SMIM14	small integral membrane protein 14	1346	0.42
chr1_56106402_56106768	0.20	ENSG00000272051	.	155940	0.04
chr2_8135764_8135915	0.20	ENSG00000221255	.	418867	0.01
chr2_216299709_216300678	0.19	FN1	fibronectin 1	597	0.55
chr4_26344236_26344574	0.19	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	357	0.93
chr10_30237773_30238416	0.19	KIAA1462	KIAA1462	110359	0.07
chr8_102513775_102514058	0.19	GRHL2	grainyhead-like 2 (Drosophila)	8930	0.22
chr9_89952337_89952906	0.19	ENSG00000212421	.	77256	0.11
chr5_154465051_154465202	0.18	ENSG00000221131	.	60766	0.13
chr9_133722351_133722531	0.18	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11988	0.21
chr3_114598031_114598292	0.18	ZBTB20	zinc finger and BTB domain containing 20	120043	0.06
chr4_57984994_57985389	0.18	IGFBP7	insulin-like growth factor binding protein 7	8640	0.18
chr20_52352609_52352999	0.18	ENSG00000238468	.	67507	0.12
chr3_110132535_110132686	0.18	ENSG00000221206	.	138202	0.05
chr10_114552420_114552740	0.18	RP11-57H14.4		30669	0.21
chr3_116583114_116583333	0.18	ENSG00000265433	.	14009	0.25
chr13_27190840_27190991	0.18	WASF3-AS1	WASF3 antisense RNA 1	24586	0.23
chr5_3597777_3597928	0.18	IRX1	iroquois homeobox 1	1684	0.41
chr10_15762100_15762293	0.18	ITGA8	integrin, alpha 8	72	0.99
chr2_119188658_119188833	0.18	INSIG2	insulin induced gene 2	342695	0.01
chr3_196080166_196080317	0.18	ENSG00000212146	.	11655	0.1
chr16_2315946_2316097	0.18	RNPS1	RNA binding protein S1, serine-rich domain	503	0.49
chr6_73262911_73263125	0.18	KCNQ5	potassium voltage-gated channel, KQT-like subfamily, member 5	68502	0.12
chr16_54968352_54968503	0.18	IRX5	iroquois homeobox 5	2443	0.45
chr6_15505200_15505483	0.17	DTNBP1	dystrobrevin binding protein 1	43252	0.19
chr1_182811531_182811809	0.17	DHX9	DEAH (Asp-Glu-Ala-His) box helicase 9	3166	0.28
chr5_80444015_80444393	0.17	CTD-2193P3.2		33533	0.2
chr1_210424215_210424840	0.17	SERTAD4-AS1	SERTAD4 antisense RNA 1	17135	0.21
chr17_12569246_12569498	0.17	MYOCD	myocardin	66	0.98
chr9_107688440_107688591	0.17	RP11-217B7.2		1319	0.43
chr3_185446261_185446412	0.17	C3orf65	chromosome 3 open reading frame 65	15256	0.21
chr2_511397_511548	0.17	TMEM18	transmembrane protein 18	164303	0.03
chr1_161932087_161932899	0.17	OLFML2B	olfactomedin-like 2B	22529	0.22
chr12_67669324_67669475	0.17	CAND1	cullin-associated and neddylation-dissociated 1	5718	0.35
chr16_73092840_73093092	0.17	ZFHX3	zinc finger homeobox 3	631	0.78
chr10_85954003_85954712	0.17	CDHR1	cadherin-related family member 1	53	0.97
chr8_23202144_23202555	0.17	ENSG00000253837	.	8628	0.17
chr14_36409550_36409712	0.17	RP11-116N8.1		42443	0.16
chr12_66220556_66220804	0.17	HMGA2	high mobility group AT-hook 2	1777	0.39
chr2_58272799_58272950	0.17	VRK2	vaccinia related kinase 2	855	0.7
chr14_81789696_81789847	0.17	STON2	stonin 2	46494	0.18
chr1_154840943_154841324	0.17	KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	338	0.86
chr15_33154166_33154394	0.17	FMN1	formin 1	26175	0.19
chr3_169189329_169189480	0.17	RP11-641D5.2		23749	0.25
chr22_43400050_43400213	0.16	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	1685	0.39
chr7_14598843_14598994	0.16	ENSG00000221428	.	216113	0.02
chr3_55062884_55063062	0.16	LRTM1	leucine-rich repeats and transmembrane domains 1	61858	0.15
chr1_198393639_198393891	0.16	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	116039	0.07
chr9_3794141_3794308	0.16	RP11-252M18.3		81360	0.1
chr15_33135515_33135666	0.16	FMN1	formin 1	44865	0.14
chr10_33248509_33248959	0.16	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1574	0.52
chr2_200446222_200446758	0.16	SATB2	SATB homeobox 2	110501	0.07
chr1_172327450_172327703	0.16	ENSG00000206684	.	8104	0.18
chr4_83810146_83810528	0.16	SEC31A	SEC31 homolog A (S. cerevisiae)	1834	0.28
chr1_16007655_16007806	0.16	PLEKHM2	pleckstrin homology domain containing, family M (with RUN domain) member 2	3097	0.14
chr22_46476561_46476775	0.15	FLJ27365	hsa-mir-4763	476	0.66
chr18_20612011_20612377	0.15	ENSG00000223023	.	7635	0.17
chr6_33589286_33590289	0.15	ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	626	0.65
chr11_79793585_79793736	0.15	ENSG00000221551	.	390237	0.01
chr5_38807697_38807893	0.15	RP11-122C5.3		24113	0.22
chr10_63596511_63596662	0.15	ARID5B	AT rich interactive domain 5B (MRF1-like)	64473	0.13
chrX_78002931_78003376	0.15	LPAR4	lysophosphatidic acid receptor 4	72	0.99
chr5_170763491_170764141	0.15	ENSG00000265740	.	22305	0.14
chr2_132120817_132121347	0.15	FAR2P4	fatty acyl CoA reductase 2 pseudogene 4	66666	0.1
chr12_54418548_54418910	0.15	HOXC6	homeobox C6	3413	0.09
chr11_12849556_12849989	0.15	RP11-47J17.3		4558	0.23
chr4_176622049_176622200	0.15	GPM6A	glycoprotein M6A	86414	0.1
chr7_121944638_121944844	0.15	FEZF1	FEZ family zinc finger 1	182	0.61
chr10_119132010_119132432	0.15	PDZD8	PDZ domain containing 8	2757	0.3
chr15_47476270_47477144	0.15	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	409	0.87
chr21_17909068_17909746	0.15	ENSG00000207638	.	2002	0.33
chr3_188841418_188841569	0.15	TPRG1	tumor protein p63 regulated 1	23583	0.27
chr6_106246069_106246220	0.15	ENSG00000200198	.	106104	0.08
chr12_115135696_115136278	0.15	TBX3	T-box 3	14018	0.21
chr16_11655655_11655806	0.14	LITAF	lipopolysaccharide-induced TNF factor	24499	0.15
chr6_28442401_28443147	0.14	ZSCAN23	zinc finger and SCAN domain containing 23	31530	0.13
chr18_53253101_53253291	0.14	TCF4	transcription factor 4	1	0.99
chr14_74724486_74725063	0.14	VSX2	visual system homeobox 2	18599	0.14
chr7_146980619_146980770	0.14	ENSG00000221442	.	94519	0.09
chr3_192288894_192289136	0.14	ENSG00000238902	.	37114	0.17
chr2_71772491_71772642	0.14	DYSF	dysferlin	78734	0.11
chr17_39874099_39874250	0.14	ENSG00000201920	.	232	0.86
chr10_74436092_74436294	0.14	MCU	mitochondrial calcium uniporter	15696	0.15
chr4_66301222_66301373	0.14	EPHA5	EPH receptor A5	234356	0.02
chr3_168825494_168825645	0.14	MECOM	MDS1 and EVI1 complex locus	20253	0.29
chr15_101899572_101899723	0.14	PCSK6	proprotein convertase subtilisin/kexin type 6	6820	0.2
chr1_120255525_120255935	0.14	PHGDH	phosphoglycerate dehydrogenase	1220	0.51
chr5_82771308_82771459	0.14	VCAN	versican	3639	0.35
chr13_60348574_60349034	0.14	DIAPH3-AS1	DIAPH3 antisense RNA 1	238081	0.02
chr3_114790766_114791082	0.14	ZBTB20	zinc finger and BTB domain containing 20	702	0.82
chr7_19141522_19141673	0.14	AC003986.6		10500	0.16
chr1_112604147_112604298	0.14	KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	72445	0.11
chr6_18028807_18028958	0.13	KIF13A	kinesin family member 13A	41028	0.18
chr22_36232810_36232961	0.13	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	3380	0.35
chr3_27367755_27367906	0.13	NEK10	NIMA-related kinase 10	34782	0.16
chr10_6836277_6836922	0.13	PRKCQ	protein kinase C, theta	214336	0.02
chr3_25472946_25473178	0.13	RARB	retinoic acid receptor, beta	3260	0.35
chr3_100923421_100923572	0.13	ENSG00000238312	.	2820	0.37
chr14_21564786_21565064	0.13	ZNF219	zinc finger protein 219	1874	0.17
chr12_120246427_120246712	0.13	CIT	citron (rho-interacting, serine/threonine kinase 21)	5382	0.27
chr1_231997217_231997368	0.13	DISC1-IT1	DISC1 intronic transcript 1 (non-protein coding)	64288	0.14
chr21_30502420_30502571	0.13	MAP3K7CL	MAP3K7 C-terminal like	311	0.86
chr11_128811477_128811628	0.13	TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1	1270	0.42
chr11_111667514_111667665	0.13	PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	30438	0.12
chr1_149378983_149379172	0.13	FCGR1C	Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene	9720	0.13
chr4_14169430_14169581	0.13	ENSG00000252092	.	509254	0.0
chr5_147836900_147837051	0.13	CTD-2283N19.1		26605	0.18
chr5_164797749_164797900	0.13	ENSG00000252794	.	238622	0.02
chr1_70509689_70509840	0.13	RP11-181B18.1		12859	0.27
chr11_34648519_34648670	0.13	EHF	ets homologous factor	2771	0.38
chr18_31157392_31158104	0.13	ASXL3	additional sex combs like 3 (Drosophila)	848	0.76
chr8_99961176_99961327	0.13	OSR2	odd-skipped related transciption factor 2	631	0.7
chr14_89507425_89507846	0.13	FOXN3	forkhead box N3	139453	0.05
chr13_33858125_33858279	0.13	STARD13	StAR-related lipid transfer (START) domain containing 13	1690	0.4
chr12_80838762_80838913	0.13	PTPRQ	protein tyrosine phosphatase, receptor type, Q	711	0.78
chr7_102532238_102532586	0.13	LRRC17	leucine rich repeat containing 17	21026	0.16
chr19_34113333_34113659	0.13	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	619	0.82
chr22_46471692_46472277	0.13	FLJ27365	hsa-mir-4763	4208	0.11
chr10_126846587_126846738	0.13	CTBP2	C-terminal binding protein 2	623	0.83
chr10_104306894_104307045	0.13	ENSG00000242311	.	21247	0.12
chr7_5620896_5621047	0.13	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11468	0.14
chr9_78870959_78871162	0.13	PCSK5	proprotein convertase subtilisin/kexin type 5	67505	0.13
chr17_75567549_75568025	0.13	SEPT9	septin 9	89792	0.07
chr14_99720527_99720678	0.13	AL109767.1		8683	0.22
chr1_151960835_151961083	0.13	S100A10	S100 calcium binding protein A10	4095	0.17
chr8_95447406_95448205	0.13	FSBP	fibrinogen silencer binding protein	1365	0.47
chr17_39065845_39065996	0.12	AC004231.2		11762	0.09
chr18_59619337_59619488	0.12	RNF152	ring finger protein 152	57948	0.16
chr10_95224937_95225088	0.12	MYOF	myoferlin	16939	0.19
chr13_95952806_95953583	0.12	ABCC4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	395	0.86
chr5_58055562_58056142	0.12	RP11-479O16.1		24754	0.24
chr15_50648671_50648965	0.12	ENSG00000244879	.	150	0.91
chr22_46483352_46483503	0.12	FLJ27365	hsa-mir-4763	1544	0.22
chr14_54423071_54423266	0.12	BMP4	bone morphogenetic protein 4	361	0.91
chr20_14317138_14317687	0.12	FLRT3	fibronectin leucine rich transmembrane protein 3	842	0.69
chr7_5637609_5637772	0.12	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	3373	0.21
chr5_158036732_158037177	0.12	CTD-2363C16.1		373060	0.01
chr7_107640774_107640963	0.12	ENSG00000238297	.	441	0.76
chr14_22330961_22331112	0.12	ENSG00000222776	.	82251	0.1
chr14_103541034_103541185	0.12	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	17310	0.15
chr19_1745649_1745800	0.12	ONECUT3	one cut homeobox 3	6648	0.14
chr2_48675517_48675668	0.12	PPP1R21	protein phosphatase 1, regulatory subunit 21	7324	0.23
chr15_96878465_96878729	0.12	ENSG00000222651	.	2107	0.24
chr17_78194664_78195096	0.12	SGSH	N-sulfoglucosamine sulfohydrolase	158	0.63
chr1_200865204_200865355	0.12	C1orf106	chromosome 1 open reading frame 106	1330	0.42
chr1_46714502_46714653	0.12	RAD54L	RAD54-like (S. cerevisiae)	1136	0.42
chr17_11640186_11640337	0.12	ENSG00000263623	.	4520	0.33

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.3	GO:0070141	response to UV-A(GO:0070141)
0.1	0.2	GO:0021542	dentate gyrus development(GO:0021542)
0.1	0.2	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.3	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.2	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.0	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.2	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.0	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0000768	syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.1	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0002076	osteoblast development(GO:0002076)
0.0	0.0	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:2000144	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.1	GO:0071437	invadopodium(GO:0071437)
0.4	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.3	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.4	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.3	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.4	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions