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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NFIA

Z-value: 2.26

Motif logo

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Transcription factors associated with NFIA

Gene Symbol Gene ID Gene Info
ENSG00000162599.11 NFIA

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
NFIAchr1_61559773_6155992457640.2231060.844.6e-03Click!
NFIAchr1_61369624_61369775387680.1907770.844.8e-03Click!
NFIAchr1_61087259_610874102435970.0191570.801.0e-02Click!
NFIAchr1_61369172_61369323383160.1924440.781.2e-02Click!
NFIAchr1_61567361_61567574133830.1974810.781.3e-02Click!

Activity of the NFIA motif across conditions

Conditions sorted by the z-value of the NFIA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_36549458_36550287 0.98 TEKT2
tektin 2 (testicular)
196
0.92
chr12_72667295_72667865 0.85 TRHDE
thyrotropin-releasing hormone degrading enzyme
317
0.85
chr5_121409447_121409998 0.78 LOX
lysyl oxidase
4258
0.27
chr6_75913619_75913933 0.76 COL12A1
collagen, type XII, alpha 1
1268
0.52
chr8_13371594_13371816 0.66 DLC1
deleted in liver cancer 1
569
0.79
chr12_78334342_78334902 0.63 NAV3
neuron navigator 3
25434
0.27
chr6_28442401_28443147 0.62 ZSCAN23
zinc finger and SCAN domain containing 23
31530
0.13
chr4_187647302_187647732 0.62 FAT1
FAT atypical cadherin 1
359
0.93
chr18_43732416_43732901 0.61 C18orf25
chromosome 18 open reading frame 25
20861
0.15
chr2_158113918_158114875 0.60 GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
286
0.93
chr4_111557687_111558154 0.58 PITX2
paired-like homeodomain 2
256
0.95
chr17_13505362_13505866 0.57 HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
370
0.91
chr21_17567832_17567983 0.56 ENSG00000201025
.
89182
0.1
chr11_19736431_19736825 0.55 NAV2
neuron navigator 2
1485
0.49
chr2_46928125_46928276 0.54 SOCS5
suppressor of cytokine signaling 5
1874
0.38
chr13_93879365_93880233 0.54 GPC6
glypican 6
704
0.82
chr3_57529834_57530279 0.53 DNAH12
dynein, axonemal, heavy chain 12
12
0.96
chr5_92920900_92921226 0.53 ENSG00000237187
.
291
0.9
chr1_98499845_98500395 0.53 ENSG00000225206
.
10787
0.31
chr2_189839242_189839495 0.53 COL3A1
collagen, type III, alpha 1
269
0.92
chr7_22898137_22898380 0.51 ENSG00000221740
.
2026
0.38
chr3_87038977_87039181 0.51 VGLL3
vestigial like 3 (Drosophila)
773
0.79
chr7_18794250_18794418 0.50 ENSG00000222164
.
53568
0.17
chr4_57276019_57276511 0.49 AC068620.1
Uncharacterized protein
417
0.79
chr19_30719241_30719606 0.49 ZNF536
zinc finger protein 536
2
0.73
chr12_80663224_80663505 0.48 OTOGL
otogelin-like
60131
0.13
chr10_21462508_21463481 0.48 NEBL-AS1
NEBL antisense RNA 1
51
0.59
chr9_25677269_25678110 0.48 TUSC1
tumor suppressor candidate 1
1167
0.68
chr1_39980649_39981517 0.48 RP11-69E11.4

9465
0.14
chr15_47476270_47477144 0.47 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
409
0.87
chr7_134496657_134496808 0.47 CALD1
caldesmon 1
31903
0.23
chr19_4473895_4474732 0.47 HDGFRP2
Hepatoma-derived growth factor-related protein 2
576
0.53
chr5_172306134_172306575 0.46 ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
25866
0.16
chr8_99960836_99961034 0.46 OSR2
odd-skipped related transciption factor 2
315
0.88
chr10_35102956_35103650 0.46 PARD3
par-3 family cell polarity regulator
946
0.5
chr3_157154723_157155399 0.46 PTX3
pentraxin 3, long
483
0.86
chr6_34210556_34210987 0.46 HMGA1
high mobility group AT-hook 1
4203
0.23
chr7_24966998_24967280 0.46 OSBPL3
oxysterol binding protein-like 3
9427
0.25
chr10_74854370_74854615 0.46 P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
2116
0.19
chr9_21590325_21590604 0.45 MIR31HG
MIR31 host gene (non-protein coding)
30796
0.16
chr7_151433344_151433930 0.45 PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
237
0.95
chr9_684288_685148 0.45 RP11-130C19.3

837
0.67
chr1_217263352_217263815 0.45 ESRRG
estrogen-related receptor gamma
607
0.86
chr2_1746603_1747283 0.45 PXDN
peroxidasin homolog (Drosophila)
1271
0.58
chr20_9049976_9050220 0.44 PLCB4
phospholipase C, beta 4
350
0.89
chr3_114169976_114170457 0.44 ZBTB20
zinc finger and BTB domain containing 20
3314
0.33
chr10_15411519_15412658 0.44 FAM171A1
family with sequence similarity 171, member A1
970
0.7
chr1_27126217_27126431 0.44 PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
10905
0.11
chrX_17317155_17317306 0.44 ENSG00000238764
.
58823
0.13
chr19_4391760_4392235 0.44 SH3GL1
SH3-domain GRB2-like 1
1390
0.22
chr7_17315289_17315760 0.43 AC003075.4

5403
0.27
chr19_41195400_41196566 0.43 NUMBL
numb homolog (Drosophila)-like
44
0.96
chr2_190042021_190042178 0.43 COL5A2
collagen, type V, alpha 2
2506
0.34
chr6_117086060_117086951 0.43 FAM162B
family with sequence similarity 162, member B
381
0.87
chr6_11196915_11197406 0.43 RP3-510L9.1

23475
0.18
chr15_96877000_96877175 0.43 ENSG00000222651
.
597
0.47
chr7_54956069_54956673 0.43 ENSG00000252054
.
22860
0.25
chr2_240230248_240230631 0.43 HDAC4
histone deacetylase 4
468
0.8
chr16_55513844_55514378 0.43 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
201
0.95
chr1_219523892_219524043 0.43 RP11-135J2.4

176664
0.03
chr11_122027725_122027876 0.43 ENSG00000207994
.
4784
0.19
chr2_33361191_33361342 0.43 LTBP1
latent transforming growth factor beta binding protein 1
1542
0.54
chr8_122649996_122650341 0.43 HAS2-AS1
HAS2 antisense RNA 1
1365
0.48
chrX_69699751_69699953 0.42 DLG3-AS1
DLG3 antisense RNA 1
24008
0.14
chr17_42187560_42187844 0.42 HDAC5
histone deacetylase 5
1007
0.34
chr6_46702576_46703631 0.42 PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
24
0.97
chr19_13107353_13108160 0.42 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
1104
0.3
chr7_7161828_7161979 0.42 ENSG00000201218
.
19591
0.13
chr10_104060247_104060656 0.41 ENSG00000251989
.
39464
0.11
chr5_63461313_63462499 0.41 RNF180
ring finger protein 180
83
0.99
chr7_129587119_129587270 0.41 UBE2H
ubiquitin-conjugating enzyme E2H
3973
0.15
chr4_86953999_86954560 0.41 RP13-514E23.1

19252
0.19
chr11_29969978_29970129 0.40 KCNA4
potassium voltage-gated channel, shaker-related subfamily, member 4
68517
0.14
chr19_46110497_46110665 0.40 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
5111
0.1
chr14_62279468_62280189 0.40 SNAPC1
small nuclear RNA activating complex, polypeptide 1, 43kDa
50753
0.17
chr2_54684400_54684738 0.40 SPTBN1
spectrin, beta, non-erythrocytic 1
171
0.97
chr1_17867048_17867282 0.40 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
835
0.7
chr1_235795999_235796340 0.40 GNG4
guanine nucleotide binding protein (G protein), gamma 4
17124
0.25
chr7_101045325_101045684 0.40 COL26A1
collagen, type XXVI, alpha 1
39382
0.14
chr1_179096167_179096689 0.40 ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
15751
0.19
chr17_57564666_57564817 0.40 ENSG00000200889
.
50119
0.12
chr19_50141513_50142109 0.39 RRAS
related RAS viral (r-ras) oncogene homolog
1647
0.16
chr4_158143046_158143598 0.39 GRIA2
glutamate receptor, ionotropic, AMPA 2
504
0.84
chr1_170556205_170556361 0.39 RP11-576I22.2

54495
0.13
chr8_102184368_102184618 0.39 ZNF706
zinc finger protein 706
29392
0.19
chr3_188313614_188313904 0.39 LPP
LIM domain containing preferred translocation partner in lipoma
13250
0.2
chr7_101543504_101543666 0.39 CTB-181H17.1

59811
0.12
chr5_121408801_121408984 0.38 LOX
lysyl oxidase
5088
0.26
chr15_39719310_39719510 0.38 RP11-624L4.1

14
0.99
chr7_127857654_127857944 0.38 ENSG00000207705
.
9875
0.19
chr16_55513533_55513747 0.38 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
270
0.93
chr17_36621763_36622126 0.38 ARHGAP23
Rho GTPase activating protein 23
6236
0.17
chr19_56166514_56167932 0.38 U2AF2
U2 small nuclear RNA auxiliary factor 2
792
0.34
chr14_85995700_85996361 0.38 FLRT2
fibronectin leucine rich transmembrane protein 2
458
0.75
chr6_88875424_88876640 0.38 CNR1
cannabinoid receptor 1 (brain)
46
0.99
chr1_2188708_2189057 0.38 SKI
v-ski avian sarcoma viral oncogene homolog
28748
0.11
chr9_22446798_22447485 0.38 DMRTA1
DMRT-like family A1
301
0.95
chr1_201915320_201915636 0.37 LMOD1
leiomodin 1 (smooth muscle)
237
0.87
chr3_146231453_146231604 0.37 PLSCR1
phospholipid scramblase 1
15009
0.19
chr12_13351879_13352395 0.37 EMP1
epithelial membrane protein 1
2417
0.37
chr14_56792096_56792462 0.37 TMEM260
transmembrane protein 260
162793
0.04
chr4_157692546_157692809 0.37 RP11-154F14.2

69834
0.11
chr7_140016131_140016502 0.37 SLC37A3
solute carrier family 37, member 3
26973
0.14
chr11_101987791_101987942 0.37 YAP1
Yes-associated protein 1
4621
0.19
chr4_183474988_183475200 0.37 ENSG00000252343
.
5282
0.29
chr1_80447922_80448073 0.37 ENSG00000266033
.
347176
0.01
chr2_180726238_180726902 0.37 ZNF385B
zinc finger protein 385B
338
0.8
chr8_135469745_135470192 0.37 ZFAT
zinc finger and AT hook domain containing
52457
0.18
chr18_72509166_72509431 0.37 ZNF407
zinc finger protein 407
166322
0.04
chr14_80677438_80677725 0.37 DIO2
deiodinase, iodothyronine, type II
76
0.65
chr1_68516408_68516606 0.37 DIRAS3
DIRAS family, GTP-binding RAS-like 3
47
0.98
chr1_110599214_110599542 0.37 RP4-773N10.4

1584
0.28
chr20_50182108_50182395 0.37 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
2881
0.38
chr15_51464550_51464723 0.36 CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
42785
0.14
chr3_147110503_147110750 0.36 ZIC1
Zic family member 1
1056
0.5
chr1_65005729_65006114 0.36 ENSG00000264470
.
39609
0.19
chr13_44954706_44954857 0.36 SERP2
stress-associated endoplasmic reticulum protein family member 2
6803
0.28
chr16_65104457_65104608 0.36 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
1584
0.58
chr19_47735595_47736220 0.36 BBC3
BCL2 binding component 3
116
0.95
chr16_73024055_73024442 0.36 ENSG00000221799
.
5492
0.24
chr19_51226586_51226860 0.36 CLEC11A
C-type lectin domain family 11, member A
57
0.95
chr5_156973092_156973243 0.36 AC106801.1

19805
0.15
chr2_239895284_239895449 0.36 ENSG00000211566
.
660
0.69
chr12_103969261_103969414 0.36 STAB2
stabilin 2
11714
0.19
chr4_95367292_95367585 0.36 PDLIM5
PDZ and LIM domain 5
5599
0.33
chr14_85998039_85998552 0.35 FLRT2
fibronectin leucine rich transmembrane protein 2
1723
0.42
chr3_64674138_64674393 0.35 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
589
0.78
chr18_12253921_12254616 0.35 CIDEA
cell death-inducing DFFA-like effector a
50
0.98
chr16_88450130_88450579 0.35 ZNF469
zinc finger protein 469
43525
0.15
chr5_95070149_95070300 0.35 CTD-2154I11.2

2225
0.26
chr7_116169535_116169759 0.35 CAV1
caveolin 1, caveolae protein, 22kDa
3300
0.2
chr8_58907686_58908288 0.35 FAM110B
family with sequence similarity 110, member B
874
0.76
chr16_54970178_54971110 0.35 IRX5
iroquois homeobox 5
4660
0.36
chr22_19973614_19974692 0.35 ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
463
0.71
chr17_58821066_58821723 0.35 ENSG00000252534
.
5013
0.22
chr2_128453104_128453431 0.35 SFT2D3
SFT2 domain containing 3
5330
0.18
chr1_43415507_43415796 0.35 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
8849
0.19
chr14_33172715_33172866 0.35 AKAP6
A kinase (PRKA) anchor protein 6
32267
0.25
chr8_49343412_49343748 0.34 RP11-770E5.1

120547
0.06
chr2_48794075_48794240 0.34 STON1-GTF2A1L
STON1-GTF2A1L readthrough
2002
0.34
chr2_178110073_178110224 0.34 ENSG00000265396
.
10590
0.11
chr22_46484431_46484684 0.34 ENSG00000266533
.
2367
0.15
chr10_90710175_90710354 0.34 ACTA2
actin, alpha 2, smooth muscle, aorta
2266
0.25
chr6_86170308_86170602 0.34 NT5E
5'-nucleotidase, ecto (CD73)
10628
0.27
chr10_30138328_30138544 0.34 SVIL
supervillin
113703
0.06
chr3_192126971_192127690 0.34 FGF12
fibroblast growth factor 12
492
0.87
chr19_13133635_13134622 0.34 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
677
0.52
chr7_55088250_55088401 0.34 EGFR
epidermal growth factor receptor
1514
0.55
chr6_3180329_3180508 0.34 TUBB2A
tubulin, beta 2A class IIa
22658
0.13
chr15_81072135_81072315 0.34 KIAA1199
KIAA1199
513
0.83
chr9_22117681_22117895 0.34 CDKN2B-AS1
CDKN2B antisense RNA 1
4111
0.31
chr8_8775544_8775695 0.34 ENSG00000200713
.
22296
0.16
chr3_100711576_100712203 0.34 ABI3BP
ABI family, member 3 (NESH) binding protein
408
0.89
chr8_25901085_25901478 0.34 EBF2
early B-cell factor 2
1632
0.53
chr19_41725215_41725482 0.34 AXL
AXL receptor tyrosine kinase
208
0.89
chr13_76213824_76214088 0.33 LMO7
LIM domain 7
3497
0.21
chr9_17005029_17005234 0.33 ENSG00000241152
.
48768
0.18
chr11_65203008_65203266 0.33 ENSG00000245532
.
8792
0.12
chr4_27656815_27656966 0.33 ENSG00000222206
.
431841
0.01
chr14_98101817_98101968 0.33 ENSG00000240730
.
105382
0.08
chr4_87517094_87517245 0.33 PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
323
0.88
chr3_58038544_58038725 0.33 FLNB
filamin B, beta
25422
0.22
chr10_24738869_24739102 0.33 KIAA1217
KIAA1217
623
0.8
chr14_69010738_69010917 0.33 CTD-2325P2.4

84335
0.09
chrX_8698839_8699470 0.33 KAL1
Kallmann syndrome 1 sequence
1073
0.66
chr12_6335358_6335509 0.33 ENSG00000202318
.
8188
0.18
chr4_24854129_24854280 0.33 SOD3
superoxide dismutase 3, extracellular
57119
0.14
chr6_56111778_56112295 0.33 COL21A1
collagen, type XXI, alpha 1
199
0.97
chr1_1281505_1281949 0.33 DVL1
dishevelled segment polarity protein 1
2765
0.1
chr1_246948051_246948632 0.33 ENSG00000227953
.
5585
0.17
chr12_91505056_91505217 0.33 LUM
lumican
472
0.85
chr19_11086301_11086459 0.33 SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
8448
0.14
chr17_15360263_15360539 0.33 CDRT4
CMT1A duplicated region transcript 4
10524
0.19
chr13_50194281_50194827 0.33 ARL11
ADP-ribosylation factor-like 11
7881
0.21
chr17_15160744_15161217 0.33 RP11-849N15.1

3352
0.18
chr4_140808579_140808865 0.33 MAML3
mastermind-like 3 (Drosophila)
2484
0.4
chr8_9953126_9953300 0.33 MSRA
methionine sulfoxide reductase A
24
0.98
chr5_124747464_124747729 0.33 ENSG00000222107
.
60772
0.17
chr9_6788398_6788607 0.32 KDM4C
lysine (K)-specific demethylase 4C
30384
0.22
chr15_83870418_83870820 0.32 HDGFRP3
Hepatoma-derived growth factor-related protein 3
6151
0.19
chr20_50331847_50332076 0.32 ATP9A
ATPase, class II, type 9A
52906
0.15
chr5_67629922_67630135 0.32 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
41632
0.21
chr8_104385276_104385427 0.32 CTHRC1
collagen triple helix repeat containing 1
690
0.64
chr4_14113589_14113913 0.32 ENSG00000252092
.
453500
0.01
chr9_132514889_132515259 0.32 PTGES
prostaglandin E synthase
252
0.91
chr1_103572231_103572444 0.32 COL11A1
collagen, type XI, alpha 1
1397
0.61
chr5_152931288_152931447 0.32 GRIA1
glutamate receptor, ionotropic, AMPA 1
59635
0.16
chrX_151140603_151140985 0.32 GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
2349
0.22
chr2_236404663_236404814 0.32 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
1987
0.38
chr2_102383129_102383280 0.32 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
30522
0.23
chr12_95779096_95779247 0.32 RP11-167N24.6
Uncharacterized protein
4499
0.22
chr9_77344223_77344424 0.32 ENSG00000202217
.
70488
0.11
chr2_45228184_45228926 0.32 SIX2
SIX homeobox 2
8014
0.26
chr14_61612550_61612795 0.32 PRKCH
protein kinase C, eta
41605
0.17
chr7_19155713_19156221 0.32 TWIST1
twist family bHLH transcription factor 1
1328
0.36
chr11_92261148_92261323 0.32 RP11-675M1.2

119893
0.06
chr6_8433732_8434221 0.32 SLC35B3
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
1740
0.54
chr16_79605501_79605727 0.32 MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
28185
0.25
chr1_229977308_229977459 0.32 URB2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
190789
0.03
chr4_174958599_174958750 0.32 FBXO8
F-box protein 8
246140
0.02

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of NFIA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.6 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.2 0.9 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.2 0.9 GO:0043589 skin morphogenesis(GO:0043589)
0.2 0.6 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.2 0.7 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.2 0.7 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.2 0.5 GO:0031223 auditory behavior(GO:0031223)
0.2 0.5 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.2 0.5 GO:0060242 contact inhibition(GO:0060242)
0.2 0.2 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.2 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.4 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.4 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.4 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.1 1.0 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.3 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.3 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.4 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.5 GO:0070141 response to UV-A(GO:0070141)
0.1 0.2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.5 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.3 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.3 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.3 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 2.7 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.4 GO:0090049 regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.1 0.6 GO:0001878 response to yeast(GO:0001878)
0.1 0.7 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.3 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 0.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.5 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.3 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.7 GO:0060039 pericardium development(GO:0060039)
0.1 0.3 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.9 GO:0002076 osteoblast development(GO:0002076)
0.1 0.4 GO:0021670 lateral ventricle development(GO:0021670)
0.1 0.2 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.1 0.5 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 0.8 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.5 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.1 0.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.2 GO:0010665 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 0.4 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 0.8 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.2 GO:0030091 protein repair(GO:0030091)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.1 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.1 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.3 GO:0032288 myelin assembly(GO:0032288)
0.1 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 0.2 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.1 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.5 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.1 0.2 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.2 GO:0060363 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.1 0.2 GO:0060023 soft palate development(GO:0060023)
0.1 0.2 GO:0014820 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.1 0.4 GO:0045019 negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of reactive oxygen species biosynthetic process(GO:1903427) negative regulation of nitric oxide metabolic process(GO:1904406)
0.1 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.1 0.2 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 0.1 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.1 0.4 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.1 0.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:0014850 response to muscle activity(GO:0014850)
0.1 0.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 0.2 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.1 0.3 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 0.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.2 GO:0008218 bioluminescence(GO:0008218)
0.1 0.1 GO:0070091 glucagon secretion(GO:0070091)
0.1 0.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.4 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.2 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.1 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0072193 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.3 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.2 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.2 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.0 GO:0090037 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.3 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0048241 epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0060900 embryonic camera-type eye formation(GO:0060900)
0.0 0.1 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.1 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.3 GO:0042977 activation of JAK2 kinase activity(GO:0042977)
0.0 0.8 GO:0030317 sperm motility(GO:0030317)
0.0 0.7 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:1901978 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.1 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0060996 dendritic spine development(GO:0060996)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.0 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.2 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.3 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.2 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0060872 semicircular canal development(GO:0060872)
0.0 0.4 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0003307 regulation of Wnt signaling pathway involved in heart development(GO:0003307) negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.4 GO:0007520 syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.2 GO:0051938 L-glutamate import(GO:0051938)
0.0 0.0 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.4 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.6 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 0.0 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.2 GO:0072273 renal vesicle morphogenesis(GO:0072077) metanephric nephron morphogenesis(GO:0072273)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.8 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.0 GO:0061004 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 0.1 GO:0032292 Schwann cell development(GO:0014044) myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.1 GO:0060438 trachea development(GO:0060438)
0.0 0.2 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.2 GO:0031272 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:0090030 regulation of steroid hormone biosynthetic process(GO:0090030)
0.0 0.1 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.0 0.2 GO:0030146 obsolete diuresis(GO:0030146)
0.0 0.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.2 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.2 GO:0015884 folic acid transport(GO:0015884)
0.0 0.1 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.2 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.3 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.0 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0071800 podosome assembly(GO:0071800)
0.0 0.1 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.0 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.4 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.1 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.0 GO:0036445 neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.1 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.0 GO:0021591 ventricular system development(GO:0021591)
0.0 0.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0 0.3 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.2 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.1 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.2 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0045901 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.1 GO:0060013 righting reflex(GO:0060013)
0.0 0.0 GO:0006925 inflammatory cell apoptotic process(GO:0006925)
0.0 0.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.3 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.0 0.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.1 GO:0044321 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.3 GO:0006555 methionine metabolic process(GO:0006555)
0.0 0.0 GO:0042363 vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0 0.0 GO:0060457 negative regulation of digestive system process(GO:0060457)
0.0 0.7 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.2 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.3 GO:0061053 somitogenesis(GO:0001756) somite development(GO:0061053)
0.0 0.1 GO:0051927 obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0 0.0 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.0 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.0 GO:0044256 multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0 0.1 GO:0042640 anagen(GO:0042640)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.0 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.2 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.0 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0031054 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587) pre-miRNA processing(GO:0031054)
0.0 0.0 GO:0060413 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.0 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832) urinary tract smooth muscle contraction(GO:0014848)
0.0 0.1 GO:1901186 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0 0.1 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.1 GO:0070198 protein localization to chromosome, telomeric region(GO:0070198)
0.0 0.0 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.0 GO:0039656 modulation by virus of host gene expression(GO:0039656)
0.0 0.0 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.2 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.1 GO:0045176 apical protein localization(GO:0045176)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.0 GO:0043501 skeletal muscle adaptation(GO:0043501)
0.0 0.1 GO:0001662 behavioral fear response(GO:0001662)
0.0 0.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.0 GO:0048532 anatomical structure arrangement(GO:0048532)
0.0 0.0 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.0 GO:0048505 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505) regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:0007494 midgut development(GO:0007494)
0.0 0.1 GO:0048636 positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0 0.2 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.0 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.0 GO:0007530 sex determination(GO:0007530)
0.0 0.3 GO:0019233 sensory perception of pain(GO:0019233)
0.0 0.0 GO:0015853 purine nucleobase transport(GO:0006863) adenine transport(GO:0015853)
0.0 0.4 GO:0006821 chloride transport(GO:0006821)
0.0 0.0 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.0 GO:0021936 regulation of cerebellar granule cell precursor proliferation(GO:0021936) positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.0 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.0 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.1 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.1 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.0 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0098754 detoxification(GO:0098754)
0.0 0.0 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.0 GO:0021511 spinal cord patterning(GO:0021511)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.4 GO:0001764 neuron migration(GO:0001764)
0.0 0.0 GO:0060527 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0 0.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.1 GO:0090659 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.0 GO:0018119 protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0 0.2 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.1 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.0 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.0 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.0 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.1 GO:0043097 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0030934 anchoring collagen complex(GO:0030934)
0.2 1.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.7 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.3 GO:0070852 cell body fiber(GO:0070852)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.2 GO:0071437 invadopodium(GO:0071437)
0.1 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1 0.3 GO:0033268 node of Ranvier(GO:0033268)
0.1 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.3 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.4 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0042641 actomyosin(GO:0042641)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.5 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 7.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.0 GO:0044216 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 1.1 GO:0030016 myofibril(GO:0030016)
0.0 0.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.0 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0016235 aggresome(GO:0016235)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.2 0.6 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.2 0.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2 0.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 0.5 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.2 0.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.1 GO:0017166 vinculin binding(GO:0017166)
0.1 0.4 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 0.5 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.6 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.6 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.1 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.4 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 0.4 GO:0030955 potassium ion binding(GO:0030955)
0.1 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0042805 actinin binding(GO:0042805)
0.1 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0044390 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.1 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.1 0.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.3 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0005497 androgen binding(GO:0005497)
0.1 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.7 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 0.2 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.4 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.5 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.3 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0034739 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.3 GO:0030553 cGMP binding(GO:0030553)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.0 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0001077 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.0 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.3 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0004803 transposase activity(GO:0004803)
0.0 0.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.0 GO:0030354 melanin-concentrating hormone activity(GO:0030354)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.0 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0015368 calcium, potassium:sodium antiporter activity(GO:0008273) calcium:cation antiporter activity(GO:0015368) potassium ion antiporter activity(GO:0022821)
0.0 1.7 GO:0008083 growth factor activity(GO:0008083)
0.0 0.0 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0 0.0 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 3.6 GO:0030528 obsolete transcription regulator activity(GO:0030528)
0.0 0.0 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.1 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.0 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.0 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.0 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.7 NABA COLLAGENS Genes encoding collagen proteins
0.1 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 1.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.0 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.9 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.1 ST ADRENERGIC Adrenergic Pathway
0.0 0.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.1 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 2.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.1 ST GA12 PATHWAY G alpha 12 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.3 REACTOME CELL CYCLE MITOTIC Genes involved in Cell Cycle, Mitotic
0.1 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.0 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.0 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.1 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.1 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 0.3 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.1 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling