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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for NHLH1

Z-value: 1.21

Motif logo

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Transcription factors associated with NHLH1

Gene Symbol Gene ID Gene Info
NHLH1
ENSG00000171786.5 nescient helix-loop-helix 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_160346259_160346410NHLH194770.114862-0.694.1e-02Click!
chr1_160346041_160346210NHLH192680.115183-0.402.9e-01Click!
chr1_160345564_160345744NHLH187970.1159520.088.4e-01Click!

Activity of the NHLH1 motif across conditions

Conditions sorted by the z-value of the NHLH1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_1092852_1093142 1.16 IDI1
 isopentenyl-diphosphate delta isomerase 1
 1340
 0.3
chr10_1092625_1092849 1.06 IDI1
 isopentenyl-diphosphate delta isomerase 1
 1600
 0.26
chr10_1092407_1092589 0.98 IDI1
 isopentenyl-diphosphate delta isomerase 1
 1839
 0.23
chr18_11688870_11689119 0.63 GNAL
 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
 39
 0.98
chr13_26624895_26625081 0.58 SHISA2
 shisa family member 2
 181
 0.97
chr11_65374818_65375338 0.51 MAP3K11
 mitogen-activated protein kinase kinase kinase 11
 581
 0.5
chr22_31644425_31644631 0.47 LIMK2
 LIM domain kinase 2
 55
 0.96
chr9_117880836_117880987 0.46 TNC
 tenascin C
 375
 0.9
chr19_3061066_3061410 0.43 AES
 amino-terminal enhancer of split
 164
 0.92
chr12_115120954_115121265 0.42 TBX3
 T-box 3
 286
 0.93
chr11_64012846_64013110 0.42 PPP1R14B
 protein phosphatase 1, regulatory (inhibitor) subunit 14B
 310
 0.51
chrX_51637827_51638413 0.40 MAGED1
 melanoma antigen family D, 1
 1385
 0.5
chr7_55087325_55087551 0.40 EGFR
 epidermal growth factor receptor
 627
 0.83
chr3_128720113_128720357 0.37 EFCC1
 EF-hand and coiled-coil domain containing 1
 237
 0.9
chr1_27692801_27692961 0.36 MAP3K6
 mitogen-activated protein kinase kinase kinase 6
 468
 0.71
chr8_141599151_141599550 0.36 AGO2
 argonaute RISC catalytic component 2
 16637
 0.22
chr14_103523327_103523546 0.35 CDC42BPB
 CDC42 binding protein kinase beta (DMPK-like)
 363
 0.87
chr15_83953612_83953905 0.35 BNC1
 basonuclin 1
 292
 0.93
chr19_13616677_13616828 0.35 CACNA1A
 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
 286
 0.93
chr7_157483101_157483509 0.35 AC006003.3
49843
 0.15
chr11_6341290_6341712 0.34 PRKCDBP
 protein kinase C, delta binding protein
 261
 0.9
chr1_19401262_19401413 0.34 UBR4
 ubiquitin protein ligase E3 component n-recognin 4
 7397
 0.2
chr6_99796840_99797257 0.33 FAXC
 failed axon connections homolog (Drosophila)
 483
 0.83
chr14_105399017_105399245 0.33 PLD4
 phospholipase D family, member 4
 634
 0.69
chr1_2125005_2125156 0.33 C1orf86
 chromosome 1 open reading frame 86
 1100
 0.36
chr3_64008917_64009121 0.33 PSMD6
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
 113
 0.94
chr17_46620793_46621086 0.32 HOXB-AS1
 HOXB cluster antisense RNA 1
 26
 0.94
chr17_7493173_7493324 0.32 SOX15
 SRY (sex determining region Y)-box 15
 142
 0.84
chr4_120549971_120550122 0.31 PDE5A
 phosphodiesterase 5A, cGMP-specific
 100
 0.98
chr10_93392557_93392792 0.31 PPP1R3C
 protein phosphatase 1, regulatory subunit 3C
 137
 0.98
chr10_88728773_88729195 0.31 ENSG00000272734
 .
 49
 0.52
chr5_112630315_112630670 0.31 MCC
 mutated in colorectal cancers
 154
 0.97
chr9_102058986_102059155 0.31 ENSG00000222337
 .
 12766
 0.24
chr17_1618285_1618721 0.30 ENSG00000186594
 .
 1218
 0.24
chr10_118500836_118501537 0.30 HSPA12A
 heat shock 70kDa protein 12A
 899
 0.64
chr5_72922368_72922731 0.30 ARHGEF28
 Rho guanine nucleotide exchange factor (GEF) 28
 528
 0.79
chr2_220306830_220307128 0.30 SPEG
 SPEG complex locus
 206
 0.88
chr11_804070_804221 0.30 PIDD
 p53-induced death domain protein
 324
 0.68
chr2_196521999_196522280 0.30 SLC39A10
 solute carrier family 39 (zinc transporter), member 10
 34
 0.98
chr4_144435743_144436361 0.30 SMARCA5-AS1
 SMARCA5 antisense RNA 1
 264
 0.9
chr13_114566489_114566848 0.29 GAS6
 growth arrest-specific 6
 372
 0.9
chr1_2461361_2461622 0.29 HES5
 hes family bHLH transcription factor 5
 193
 0.88
chr17_62051691_62051850 0.29 SCN4A
 sodium channel, voltage-gated, type IV, alpha subunit
 1492
 0.3
chr20_50073707_50073858 0.29 ENSG00000266761
 .
 4268
 0.31
chr11_64950203_64950490 0.29 CAPN1
 calpain 1, (mu/I) large subunit
 413
 0.62
chr10_134001657_134001828 0.29 DPYSL4
 dihydropyrimidinase-like 4
 1338
 0.42
chrX_1572414_1572620 0.29 ASMTL
 acetylserotonin O-methyltransferase-like
 138
 0.96
chr14_105767785_105767936 0.29 BRF1
 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
 245
 0.85
chr7_7812087_7812527 0.28 RPA3-AS1
 RPA3 antisense RNA 1
 315
 0.93
chrY_1522413_1522621 0.28 NA
 NA
 > 106
 NA
chr11_96040354_96040983 0.27 ENSG00000266192
 .
 33934
 0.17
chr4_52917326_52917683 0.27 SPATA18
 spermatogenesis associated 18
 7
 0.98
chr1_110230464_110231016 0.27 GSTM1
 glutathione S-transferase mu 1
 260
 0.84
chr18_11908463_11908810 0.27 MPPE1
 metallophosphoesterase 1
 5
 0.55
chr11_133939469_133939706 0.27 JAM3
 junctional adhesion molecule 3
 621
 0.79
chr13_114908669_114908820 0.27 RASA3
 RAS p21 protein activator 3
 10658
 0.22
chr11_789656_789830 0.27 CEND1
 cell cycle exit and neuronal differentiation 1
 380
 0.63
chr1_227505826_227506086 0.26 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
 130
 0.98
chr6_126111801_126112009 0.26 NCOA7
 nuclear receptor coactivator 7
 96
 0.97
chr5_1295340_1295548 0.25 TERT
 telomerase reverse transcriptase
 282
 0.9
chrX_2418812_2418977 0.25 ZBED1
 zinc finger, BED-type containing 1
 42
 0.6
chr15_67356472_67356683 0.25 SMAD3
 SMAD family member 3
 476
 0.88
chr16_29910277_29910428 0.25 SEZ6L2
 seizure related 6 homolog (mouse)-like 2
 33
 0.93
chr8_141598821_141598972 0.25 AGO2
 argonaute RISC catalytic component 2
 17091
 0.22
chr2_217235630_217236249 0.25 MARCH4
 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
 811
 0.59
chrY_2368812_2368979 0.24 ENSG00000251841
 .
 283895
 0.01
chr1_152080352_152080527 0.24 TCHH
 trichohyalin
 6117
 0.14
chr2_131797674_131798057 0.24 ARHGEF4
 Rho guanine nucleotide exchange factor (GEF) 4
 985
 0.6
chr10_103347501_103347768 0.24 POLL
 polymerase (DNA directed), lambda
 249
 0.65
chr15_27212862_27213085 0.24 GABRG3
 gamma-aminobutyric acid (GABA) A receptor, gamma 3
 3456
 0.3
chr16_56660545_56660940 0.24 MT1E
 metallothionein 1E
 1032
 0.26
chr3_73673648_73674178 0.24 PDZRN3
 PDZ domain containing ring finger 3
 78
 0.96
chr14_104902871_104903022 0.24 ENSG00000222761
 .
 35561
 0.19
chr5_177541312_177541594 0.24 N4BP3
 NEDD4 binding protein 3
 1009
 0.51
chr15_83952244_83952401 0.24 BNC1
 basonuclin 1
 251
 0.94
chr16_67241052_67241203 0.23 LRRC29
 leucine rich repeat containing 29
 3861
 0.08
chr16_88701814_88701965 0.23 IL17C
 interleukin 17C
 3112
 0.13
chr1_114695259_114695512 0.23 SYT6
 synaptotagmin VI
 154
 0.97
chr12_103352417_103352568 0.23 PAH
 phenylalanine hydroxylase
 348
 0.8
chr20_3730561_3730712 0.23 C20orf27
 chromosome 20 open reading frame 27
 8689
 0.12
chr6_84761983_84762373 0.23 MRAP2
 melanocortin 2 receptor accessory protein 2
 18703
 0.28
chr12_123459866_123460094 0.23 OGFOD2
 2-oxoglutarate and iron-dependent oxygenase domain containing 2
 194
 0.53
chr20_24615638_24615855 0.22 SYNDIG1
 synapse differentiation inducing 1
 165911
 0.04
chr1_1474981_1475180 0.22 TMEM240
 transmembrane protein 240
 657
 0.54
chr6_167413267_167413526 0.22 FGFR1OP
 FGFR1 oncogene partner
 500
 0.57
chrX_100334236_100334411 0.22 TMEM35
 transmembrane protein 35
 614
 0.68
chr20_62959121_62959318 0.22 PCMTD2
 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
 62354
 0.13
chr6_170598495_170598646 0.22 DLL1
 delta-like 1 (Drosophila)
 991
 0.41
chr13_114524953_114525104 0.22 GAS6-AS1
 GAS6 antisense RNA 1
 6425
 0.22
chr2_192110869_192111020 0.22 MYO1B
 myosin IB
 65
 0.98
chr10_135106416_135106777 0.22 TUBGCP2
 tubulin, gamma complex associated protein 2
 2058
 0.16
chr2_63279236_63279503 0.22 OTX1
 orthodenticle homeobox 1
 1432
 0.46
chr11_72532728_72533160 0.21 ATG16L2
 autophagy related 16-like 2 (S. cerevisiae)
 423
 0.77
chr14_23308247_23308521 0.21 MMP14
 matrix metallopeptidase 14 (membrane-inserted)
 1863
 0.16
chr1_155293290_155293460 0.21 RUSC1
 RUN and SH3 domain containing 1
 353
 0.56
chr16_9058022_9058398 0.21 USP7
 ubiquitin specific peptidase 7 (herpes virus-associated)
 161
 0.96
chr17_18266986_18267178 0.21 SHMT1
 serine hydroxymethyltransferase 1 (soluble)
 226
 0.89
chr6_26614195_26614680 0.21 ABT1
 activator of basal transcription 1
 17257
 0.17
chr18_60277973_60278124 0.21 ENSG00000243549
 .
 39786
 0.17
chr16_56677548_56677767 0.21 MT1DP
 metallothionein 1D, pseudogene
 20
 0.93
chr20_13202499_13202944 0.21 ISM1
 isthmin 1, angiogenesis inhibitor
 303
 0.91
chr6_116381607_116382020 0.21 FRK
 fyn-related kinase
 108
 0.97
chr1_31886215_31886421 0.21 SERINC2
 serine incorporator 2
 342
 0.86
chrX_107068956_107069440 0.20 MID2
 midline 2
 89
 0.97
chr11_119186999_119187624 0.20 MCAM
 melanoma cell adhesion molecule
 515
 0.61
chr8_145909540_145910009 0.20 ARHGAP39
 Rho GTPase activating protein 39
 1420
 0.34
chr17_1011223_1011414 0.20 ABR
 active BCR-related
 1022
 0.58
chr4_62067754_62067905 0.20 LPHN3
 latrophilin 3
 31
 0.99
chr18_23806471_23806681 0.20 TAF4B
 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
 126
 0.97
chrX_139586225_139586732 0.20 SOX3
 SRY (sex determining region Y)-box 3
 747
 0.78
chr9_135038389_135038692 0.20 NTNG2
 netrin G2
 1206
 0.56
chr22_24383455_24383606 0.20 GSTT1
 glutathione S-transferase theta 1
 712
 0.53
chr10_118608958_118609220 0.20 ENO4
 enolase family member 4
 5
 0.62
chr11_86666090_86666398 0.20 FZD4
 frizzled family receptor 4
 189
 0.96
chr12_58120609_58120962 0.20 AGAP2-AS1
 AGAP2 antisense RNA 1
 731
 0.39
chr1_205417300_205417451 0.20 ENSG00000199059
 .
 151
 0.94
chr4_77870925_77871335 0.20 SEPT11
 septin 11
 115
 0.97
chr19_45281152_45281359 0.20 CBLC
 Cbl proto-oncogene C, E3 ubiquitin protein ligase
 129
 0.93
chr12_90102796_90103077 0.20 ATP2B1
 ATPase, Ca++ transporting, plasma membrane 1
 141
 0.96
chrX_140270541_140271303 0.20 LDOC1
 leucine zipper, down-regulated in cancer 1
 388
 0.86
chr6_72596608_72597181 0.19 RIMS1
 regulating synaptic membrane exocytosis 1
 167
 0.98
chr1_20811158_20811808 0.19 CAMK2N1
 calcium/calmodulin-dependent protein kinase II inhibitor 1
 1230
 0.48
chr19_59070035_59070244 0.19 UBE2M
 ubiquitin-conjugating enzyme E2M
 182
 0.66
chr11_70245277_70245996 0.19 CTTN
 cortactin
 989
 0.33
chr14_62583839_62584088 0.19 RP11-355I22.7
6370
 0.33
chrX_40944624_40944775 0.19 USP9X
 ubiquitin specific peptidase 9, X-linked
 189
 0.97
chr22_39686630_39686781 0.19 RP3-333H23.8
2288
 0.19
chr16_15083543_15083773 0.19 PDXDC1
 pyridoxal-dependent decarboxylase domain containing 1
 13038
 0.11
chr16_89988377_89988901 0.19 TUBB3
 Tubulin beta-3 chain
 315
 0.55
chr22_24353470_24353828 0.19 AP000351.8
1568
 0.24
chr22_20906440_20906695 0.19 MED15
 mediator complex subunit 15
 990
 0.46
chr6_1637512_1637663 0.19 FOXC1
 forkhead box C1
 26906
 0.26
chr19_35600814_35600965 0.19 HPN-AS1
 HPN antisense RNA 1
 3681
 0.11
chr6_170501628_170501779 0.19 RP11-302L19.1
23962
 0.21
chr6_153303975_153304186 0.19 FBXO5
 F-box protein 5
 73
 0.93
chr9_116356768_116357019 0.19 RGS3
 regulator of G-protein signaling 3
 1127
 0.54
chr1_17914943_17915229 0.19 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 175
 0.97
chr7_44298813_44298964 0.19 CAMK2B
 calcium/calmodulin-dependent protein kinase II beta
 16983
 0.18
chr2_242499136_242499442 0.18 BOK-AS1
 BOK antisense RNA 1
 897
 0.38
chr14_90863482_90863819 0.18 CALM1
 calmodulin 1 (phosphorylase kinase, delta)
 250
 0.92
chr13_96056493_96056697 0.18 CLDN10
 claudin 10
 29263
 0.19
chr6_41438506_41438660 0.18 RP11-328M4.2
75229
 0.08
chr9_98224571_98225205 0.18 PTCH1
 patched 1
 17879
 0.18
chr11_128646889_128647040 0.18 FLI1
 Fli-1 proto-oncogene, ETS transcription factor
 12279
 0.22
chr1_193154702_193155811 0.18 B3GALT2
 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
 528
 0.8
chr2_75426626_75426804 0.18 TACR1
 tachykinin receptor 1
 111
 0.98
chr9_90328572_90328919 0.18 CTSL
 cathepsin L
 11689
 0.2
chr17_80832203_80832354 0.18 TBCD
 tubulin folding cofactor D
 9750
 0.18
chr19_35521533_35521780 0.18 SCN1B
 sodium channel, voltage-gated, type I, beta subunit
 19
 0.95
chr7_150498130_150498281 0.18 TMEM176B
 transmembrane protein 176B
 243
 0.66
chr3_57996038_57996378 0.18 FLNB
 filamin B, beta
 2081
 0.42
chr2_73613395_73613732 0.18 ALMS1
 Alstrom syndrome 1
 677
 0.73
chr19_6532612_6532841 0.18 TNFSF9
 tumor necrosis factor (ligand) superfamily, member 9
 1716
 0.23
chr8_92082532_92082845 0.18 OTUD6B
 OTU domain containing 6B
 135
 0.67
chr8_22443451_22443742 0.18 AC037459.4
 Uncharacterized protein
 3191
 0.12
chr12_47164319_47164534 0.18 SLC38A4
 solute carrier family 38, member 4
 1339
 0.62
chr13_111040147_111040457 0.18 ENSG00000238629
 .
 26250
 0.19
chr10_104210626_104210853 0.17 ENSG00000269609
 .
 351
 0.57
chr8_65494091_65494563 0.17 RP11-21C4.1
118
 0.96
chr6_28554604_28555086 0.17 SCAND3
 SCAN domain containing 3
 267
 0.92
chr20_60925711_60925862 0.17 RP11-157P1.5
2265
 0.19
chr8_29522987_29523177 0.17 ENSG00000221003
 .
 263039
 0.01
chr7_65822632_65822783 0.17 ENSG00000252126
 .
 13416
 0.2
chr5_134944090_134944241 0.17 CXCL14
 chemokine (C-X-C motif) ligand 14
 29196
 0.16
chr17_47653239_47653774 0.17 NXPH3
 neurexophilin 3
 22
 0.95
chr10_27531146_27531464 0.17 ACBD5
 acyl-CoA binding domain containing 5
 246
 0.89
chr19_17185147_17185420 0.17 HAUS8
 HAUS augmin-like complex, subunit 8
 727
 0.47
chr12_72666876_72667203 0.17 TRHDE
 thyrotropin-releasing hormone degrading enzyme
 224
 0.85
chr4_170037457_170037608 0.17 RP11-327O17.2
85413
 0.08
chr9_96589949_96590137 0.17 ENSG00000265347
 .
 8404
 0.29
chr19_10531284_10531435 0.17 PDE4A
 phosphodiesterase 4A, cAMP-specific
 28
 0.9
chr6_100051015_100051219 0.17 PRDM13
 PR domain containing 13
 3489
 0.22
chr17_78833031_78833182 0.17 RP11-28G8.1
53674
 0.1
chr6_150390611_150390768 0.17 ULBP3
 UL16 binding protein 3
 458
 0.82
chrX_82766329_82766480 0.17 RP3-326L13.2
2182
 0.36
chr19_38146354_38146681 0.17 ZFP30
 ZFP30 zinc finger protein
 149
 0.95
chrX_69654840_69655096 0.17 DLG3
 discs, large homolog 3 (Drosophila)
 9743
 0.14
chr12_50015766_50015944 0.17 PRPF40B
 PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
 1364
 0.35
chr19_5904904_5905447 0.16 VMAC
 vimentin-type intermediate filament associated coiled-coil protein
 306
 0.68
chr19_4304677_4304951 0.16 FSD1
 fibronectin type III and SPRY domain containing 1
 128
 0.91
chr14_23447268_23447766 0.16 AJUBA
 ajuba LIM protein
 571
 0.5
chr19_21666073_21666487 0.16 ZNF429
 zinc finger protein 429
 22086
 0.22
chr20_62185445_62185854 0.16 C20orf195
 chromosome 20 open reading frame 195
 153
 0.91
chr4_176593006_176593157 0.16 GPM6A
 glycoprotein M6A
 115457
 0.06
chr6_153451642_153452011 0.16 RGS17
 regulator of G-protein signaling 17
 558
 0.79
chr17_19771318_19771635 0.16 ULK2
 unc-51 like autophagy activating kinase 2
 227
 0.94
chr16_81349076_81349337 0.16 GAN
 gigaxonin
 649
 0.67
chr22_46469619_46469920 0.16 RP6-109B7.4
3998
 0.12
chr6_3455456_3455921 0.16 SLC22A23
 solute carrier family 22, member 23
 589
 0.84
chr17_6459033_6459314 0.16 PITPNM3
 PITPNM family member 3
 607
 0.7
chr15_95869891_95870263 0.16 ENSG00000222076
 .
 418956
 0.01
chrX_48930077_48930476 0.16 PRAF2
 PRA1 domain family, member 2
 1372
 0.22
chr10_17272457_17272817 0.16 VIM
 vimentin
 29
 0.92
chr11_120206324_120206586 0.16 ARHGEF12
 Rho guanine nucleotide exchange factor (GEF) 12
 1332
 0.42
chr11_62211663_62212209 0.16 CTD-2531D15.4
17740
 0.11
chr15_99645907_99646604 0.16 RP11-654A16.3
225
 0.85
chr7_141400668_141400819 0.16 KIAA1147
 KIAA1147
 672
 0.56
chr2_106012197_106012348 0.16 FHL2
 four and a half LIM domains 2
 970
 0.58
chr4_99404298_99404452 0.16 RP11-724M22.1
13140
 0.27
chr5_175560458_175560649 0.16 FAM153B
 family with sequence similarity 153, member B
 48644
 0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.1 0.4 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.4 GO:0032351 negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.1 0.5 GO:0070141 response to UV-A(GO:0070141)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.1 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 0.3 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.3 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.1 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.2 GO:0060916 mesenchymal cell proliferation involved in lung development(GO:0060916)
0.1 0.2 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.2 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.2 GO:0007144 female meiosis I(GO:0007144)
0.1 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 0.2 GO:1900121 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1 0.4 GO:0046146 tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.2 GO:0010193 response to ozone(GO:0010193)
0.1 0.5 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.1 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.0 0.2 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0022009 establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0 0.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0061140 lung secretory cell differentiation(GO:0061140)
0.0 0.1 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.6 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0032202 telomere assembly(GO:0032202)
0.0 0.1 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0061162 establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.1 GO:0051608 histamine transport(GO:0051608)
0.0 0.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.3 GO:0060324 face development(GO:0060324)
0.0 0.1 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.2 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.2 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0040023 establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.3 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0046541 saliva secretion(GO:0046541)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:1901889 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0071637 monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.0 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.3 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.1 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.1 GO:0021903 rostrocaudal neural tube patterning(GO:0021903)
0.0 0.2 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.2 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0034331 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.4 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.1 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.3 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.0 GO:2000192 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0 0.2 GO:0032400 melanosome localization(GO:0032400)
0.0 0.0 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.1 GO:0045006 DNA deamination(GO:0045006)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.2 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.0 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.0 GO:0043501 skeletal muscle adaptation(GO:0043501)
0.0 0.0 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614) negative regulation of muscle hypertrophy(GO:0014741)
0.0 0.1 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.1 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.1 GO:0015811 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.1 GO:0001554 luteolysis(GO:0001554)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.1 GO:0090026 regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:0048636 positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0 0.0 GO:0019322 pentose biosynthetic process(GO:0019322)
0.0 0.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.1 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0070265 necrotic cell death(GO:0070265)
0.0 0.0 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.0 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0032648 regulation of interferon-beta production(GO:0032648)
0.0 0.1 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.0 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.1 GO:0009209 GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0 0.6 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.0 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0 0.1 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.0 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.0 GO:0032647 interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042587 glycogen granule(GO:0042587)
0.1 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.3 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.1 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.5 GO:0043204 perikaryon(GO:0043204)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0044447 axoneme part(GO:0044447)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.0 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045545 syndecan binding(GO:0045545)
0.1 0.4 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0005113 patched binding(GO:0005113)
0.1 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.2 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.0 GO:0034618 arginine binding(GO:0034618)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.3 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.6 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0004516 nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.4 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0051117 ATPase binding(GO:0051117)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.0 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.0 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.0 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.2 GO:0008483 transaminase activity(GO:0008483)
0.0 0.0 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.0 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.0 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor