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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX1-1

Z-value: 0.59

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Transcription factors associated with NKX1-1

Gene Symbol	Gene ID	Gene Info
NKX1-1 Ensembl NCBI GeneCards UniProt	ENSG00000235608.1	NKX1-1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX1-1	chr4_1397780_1397931	2264	0.241866	0.62	7.7e-02	Click!
NKX1-1	chr4_1514830_1514981	114786	0.046413	0.51	1.6e-01	Click!
NKX1-1	chr4_1514451_1514602	114407	0.046649	0.48	1.9e-01	Click!
NKX1-1	chr4_1523235_1523394	123195	0.041550	0.34	3.7e-01	Click!
NKX1-1	chr4_1513980_1514175	113958	0.046929	-0.16	6.7e-01	Click!

Activity of the NKX1-1 motif across conditions

Conditions sorted by the z-value of the NKX1-1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_196577911_196578299	0.33	KCNT2	potassium channel, subfamily T, member 2	250	0.94
chr13_68202936_68203087	0.27	PCDH9	protocadherin 9	398543	0.01
chr12_28124078_28124290	0.25	PTHLH	parathyroid hormone-like hormone	719	0.71
chr2_101620301_101620452	0.24	RPL31	ribosomal protein L31	1175	0.38
chr4_83810146_83810528	0.23	SEC31A	SEC31 homolog A (S. cerevisiae)	1834	0.28
chr6_117804579_117805184	0.23	DCBLD1	discoidin, CUB and LCCL domain containing 1	1056	0.49
chr1_23494434_23494599	0.23	LUZP1	leucine zipper protein 1	794	0.54
chr9_13278507_13279169	0.22	RP11-272P10.2		348	0.67
chr4_89522534_89522685	0.22	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	4336	0.21
chr4_157891142_157892336	0.21	PDGFC	platelet derived growth factor C	316	0.91
chr6_27263961_27264170	0.20	POM121L2	POM121 transmembrane nucleoporin-like 2	15026	0.2
chr5_57752049_57752200	0.20	PLK2	polo-like kinase 2	3963	0.27
chr16_13401641_13401792	0.19	AC003009.1		24724	0.26
chr7_80513051_80513202	0.19	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	35373	0.24
chr21_16435398_16436179	0.18	NRIP1	nuclear receptor interacting protein 1	1338	0.57
chr22_46476561_46476775	0.18	FLJ27365	hsa-mir-4763	476	0.66
chr17_35289223_35289419	0.18	RP11-445F12.1		4600	0.15
chr5_180529470_180529621	0.18	OR2V1	olfactory receptor, family 2, subfamily V, member 1	22759	0.13
chr6_136888235_136888386	0.18	MAP7	microtubule-associated protein 7	16353	0.15
chr20_43965593_43965922	0.18	SDC4	syndecan 4	11307	0.11
chr10_102760785_102760994	0.17	LZTS2	leucine zipper, putative tumor suppressor 2	1279	0.27
chrX_25020829_25021251	0.17	ARX	aristaless related homeobox	13025	0.26
chr9_72745702_72745853	0.17	MAMDC2-AS1	MAMDC2 antisense RNA 1	17001	0.22
chr15_70384069_70384220	0.17	TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	2980	0.31
chr11_122049732_122050124	0.17	ENSG00000207994	.	26912	0.16
chr18_20612011_20612377	0.17	ENSG00000223023	.	7635	0.17
chr21_27778313_27779012	0.17	AP001597.1		400	0.89
chr8_94507892_94508285	0.16	ENSG00000222416	.	54583	0.14
chr5_180523773_180523999	0.16	OR2V1	olfactory receptor, family 2, subfamily V, member 1	28418	0.12
chr12_115120620_115120912	0.16	TBX3	T-box 3	629	0.77
chr2_163171316_163171467	0.16	IFIH1	interferon induced with helicase C domain 1	3803	0.25
chr12_53896533_53896684	0.16	TARBP2	TAR (HIV-1) RNA binding protein 2	773	0.43
chr2_163157606_163157781	0.16	IFIH1	interferon induced with helicase C domain 1	17501	0.19
chr14_62032902_62033075	0.16	RP11-47I22.3	Uncharacterized protein	4326	0.24
chr1_109741279_109741478	0.16	ENSG00000238310	.	9092	0.15
chr10_131555251_131555402	0.15	RP11-109A6.2		55505	0.15
chr18_59619337_59619488	0.15	RNF152	ring finger protein 152	57948	0.16
chr6_27263399_27263763	0.15	POM121L2	POM121 transmembrane nucleoporin-like 2	15510	0.2
chr6_49794571_49794884	0.15	RP3-417L20.4		9584	0.19
chr17_41668751_41668949	0.15	ETV4	ets variant 4	11862	0.16
chr4_186768313_186768795	0.14	SORBS2	sorbin and SH3 domain containing 2	34276	0.19
chr14_103058041_103058305	0.14	RCOR1	REST corepressor 1	825	0.6
chr15_69367071_69367289	0.14	RP11-809H16.4		31275	0.17
chr4_75550401_75550552	0.14	AC142293.3		35812	0.18
chr10_30347491_30347726	0.14	KIAA1462	KIAA1462	845	0.76
chr13_114599987_114600138	0.14	GAS6	growth arrest-specific 6	33016	0.2
chr6_37210883_37211034	0.14	ENSG00000238375	.	8124	0.16
chr11_12716213_12716424	0.14	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	19268	0.26
chr1_45826795_45827032	0.14	ENSG00000238945	.	2493	0.23
chr8_334889_335040	0.14	FBXO25	F-box protein 25	21464	0.22
chr6_41472777_41473161	0.14	RP11-328M4.2		40843	0.13
chr4_31656800_31656951	0.14	RP11-619J20.1		861283	0.0
chr15_67334428_67334662	0.14	SMAD3	SMAD family member 3	21556	0.25
chr5_172665530_172665713	0.14	NKX2-5	NK2 homeobox 5	3261	0.23
chr4_1005974_1006310	0.13	FGFRL1	fibroblast growth factor receptor-like 1	97	0.95
chr4_163496269_163496420	0.13	FSTL5	follistatin-like 5	411157	0.01
chr9_133711223_133711921	0.13	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	1119	0.56
chr3_79417981_79418132	0.13	ENSG00000265193	.	138981	0.05
chr16_19606642_19606793	0.13	C16orf62	chromosome 16 open reading frame 62	12381	0.18
chr11_94661378_94661529	0.13	RP11-856F16.2		2767	0.3
chr19_4402510_4402661	0.13	CHAF1A	chromatin assembly factor 1, subunit A (p150)	74	0.93
chr2_63815441_63815904	0.13	WDPCP	WD repeat containing planar cell polarity effector	20	0.54
chr5_127874204_127874722	0.13	FBN2	fibrillin 2	547	0.58
chr14_93552039_93552233	0.13	ITPK1-AS1	ITPK1 antisense RNA 1	18339	0.18
chr19_2962281_2962480	0.13	TLE6	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	15064	0.12
chr8_29200137_29200318	0.13	DUSP4	dual specificity phosphatase 4	6095	0.17
chr2_188418561_188419245	0.13	AC007319.1		27	0.69
chr2_242256486_242256668	0.12	HDLBP	high density lipoprotein binding protein	101	0.93
chr8_98880755_98880906	0.12	MATN2	matrilin 2	238	0.95
chr8_124284035_124284186	0.12	ZHX1	zinc fingers and homeoboxes 1	2437	0.16
chr16_85202371_85202571	0.12	CTC-786C10.1		2411	0.35
chr11_95646755_95646928	0.12	MTMR2	myotubularin related protein 2	600	0.82
chr6_62996046_62996197	0.12	KHDRBS2	KH domain containing, RNA binding, signal transduction associated 2	11	0.99
chr7_63385679_63385830	0.12	ENSG00000265017	.	1460	0.47
chr8_126323291_126323442	0.12	RP11-550A5.2		40292	0.16
chr1_206593163_206593314	0.12	SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	13502	0.18
chr6_165341311_165341481	0.12	C6orf118	chromosome 6 open reading frame 118	380946	0.01
chr13_26043049_26043230	0.12	ATP8A2	ATPase, aminophospholipid transporter, class I, type 8A, member 2	26	0.98
chr12_42875750_42875901	0.12	PRICKLE1	prickle homolog 1 (Drosophila)	1049	0.48
chr9_110400275_110400607	0.12	ENSG00000202308	.	25086	0.24
chr14_91091040_91091191	0.12	TTC7B	tetratricopeptide repeat domain 7B	6748	0.2
chr8_124195558_124195709	0.11	RP11-539E17.5		605	0.42
chr1_115258427_115259019	0.11	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	792	0.54
chr5_174178214_174178699	0.11	ENSG00000266890	.	281	0.94
chr8_36807823_36808005	0.11	KCNU1	potassium channel, subfamily U, member 1	21491	0.29
chr3_154797621_154798368	0.11	MME	membrane metallo-endopeptidase	94	0.98
chr17_47547430_47548013	0.11	NGFR	nerve growth factor receptor	24934	0.13
chr3_159483781_159484285	0.11	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr9_82795299_82795450	0.11	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	473693	0.01
chr2_5837836_5837987	0.11	SOX11	SRY (sex determining region Y)-box 11	5112	0.22
chr4_66536403_66536611	0.11	EPHA5	EPH receptor A5	294	0.95
chr13_106426830_106427002	0.11	ENSG00000252550	.	123076	0.06
chr4_75858398_75858601	0.11	PARM1	prostate androgen-regulated mucin-like protein 1	173	0.97
chr6_47666951_47667231	0.11	GPR115	G protein-coupled receptor 115	802	0.64
chr10_105559478_105559629	0.11	SH3PXD2A	SH3 and PX domains 2A	1502	0.47
chr18_77662426_77662577	0.11	KCNG2	potassium voltage-gated channel, subfamily G, member 2	38833	0.15
chr15_33323538_33323689	0.11	FMN1	formin 1	36472	0.19
chr10_119302142_119302346	0.11	EMX2	empty spiracles homeobox 2	265	0.64
chr11_2834821_2835116	0.11	KCNQ1-AS1	KCNQ1 antisense RNA 1	47830	0.11
chr6_7312252_7312483	0.11	SSR1	signal sequence receptor, alpha	1040	0.57
chr12_59314342_59314656	0.11	RP11-150C16.1		79	0.67
chr13_53192037_53192369	0.10	HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2	598	0.79
chr13_107160462_107160937	0.10	EFNB2	ephrin-B2	26763	0.24
chr2_44935412_44935824	0.10	ENSG00000252896	.	73651	0.12
chr14_76604893_76605206	0.10	GPATCH2L	G patch domain containing 2-like	13213	0.26
chr5_102897969_102898137	0.10	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	437	0.91
chr3_16024121_16024347	0.10	ENSG00000207815	.	108956	0.06
chr10_6763782_6764322	0.10	PRKCQ	protein kinase C, theta	141789	0.05
chr2_8135764_8135915	0.10	ENSG00000221255	.	418867	0.01
chr5_36951473_36951624	0.10	NIPBL	Nipped-B homolog (Drosophila)	74656	0.12
chr7_132088071_132088231	0.10	AC011625.1		51058	0.17
chr11_105892671_105892946	0.10	MSANTD4	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	146	0.96
chr1_146641853_146642189	0.10	PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	2025	0.25
chr6_136887685_136887836	0.10	MAP7	microtubule-associated protein 7	15803	0.16
chr6_26312991_26313348	0.10	HIST1H4H	histone cluster 1, H4h	27407	0.07
chr2_5619821_5619972	0.10	AC108025.2		211282	0.02
chr11_16809886_16810037	0.10	PLEKHA7	pleckstrin homology domain containing, family A member 7	24069	0.19
chr11_117778647_117778798	0.10	TMPRSS13	transmembrane protease, serine 13	21358	0.14
chr1_2461773_2461924	0.10	HES5	hes family bHLH transcription factor 5	164	0.9
chr1_226109753_226109904	0.10	PYCR2	pyrroline-5-carboxylate reductase family, member 2	2131	0.19
chr7_32929941_32930760	0.10	KBTBD2	kelch repeat and BTB (POZ) domain containing 2	415	0.87
chr10_17547257_17547425	0.10	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	51012	0.13
chr11_109294220_109294371	0.10	C11orf87	chromosome 11 open reading frame 87	1449	0.58
chr1_209975427_209975724	0.10	IRF6	interferon regulatory factor 6	64	0.96
chr9_13278250_13278433	0.10	RP11-272P10.2		845	0.51
chr14_42609890_42610041	0.10	ENSG00000222084	.	159989	0.04
chr19_4343203_4343398	0.10	MPND	MPN domain containing	224	0.83
chr20_10502111_10502382	0.09	SLX4IP	SLX4 interacting protein	86295	0.09
chr8_80696427_80696819	0.09	ENSG00000238884	.	15807	0.22
chr15_41274840_41275069	0.09	RP11-540O11.6		16518	0.12
chr17_40574158_40574426	0.09	PTRF	polymerase I and transcript release factor	1243	0.31
chr12_17033936_17034087	0.09	ENSG00000212358	.	190428	0.03
chr10_12746098_12746480	0.09	ENSG00000221331	.	21063	0.25
chr8_31771478_31771629	0.09	NRG1-IT1	NRG1 intronic transcript 1 (non-protein coding)	112182	0.07
chr15_31690130_31690281	0.09	KLF13	Kruppel-like factor 13	31848	0.24
chr15_96870341_96870527	0.09	NR2F2-AS1	NR2F2 antisense RNA 1	89	0.95
chr3_170527527_170527678	0.09	ENSG00000222411	.	32359	0.19
chr5_36873918_36874176	0.09	NIPBL	Nipped-B homolog (Drosophila)	2814	0.4
chr10_44277299_44277450	0.09	ZNF32	zinc finger protein 32	133070	0.05
chr3_171848594_171848745	0.09	FNDC3B	fibronectin type III domain containing 3B	3905	0.33
chr2_216876893_216877044	0.09	MREG	melanoregulin	1378	0.5
chr5_36842382_36842533	0.09	NIPBL	Nipped-B homolog (Drosophila)	34404	0.22
chr13_37006714_37007207	0.09	CCNA1	cyclin A1	465	0.85
chr5_82767889_82768074	0.09	VCAN	versican	237	0.96
chr15_43576768_43576919	0.09	RP11-402F9.3		17451	0.1
chr7_29603770_29603921	0.09	PRR15	proline rich 15	418	0.58
chrX_45482024_45482567	0.09	ENSG00000207870	.	123399	0.06
chr7_70596624_70596819	0.09	WBSCR17	Williams-Beuren syndrome chromosome region 17	434	0.91
chr8_37915323_37915474	0.09	KB-1836B5.1		5001	0.15
chr19_37743129_37743340	0.09	ZNF383	zinc finger protein 383	24782	0.13
chr12_70381241_70381594	0.09	RP11-611E13.3		40556	0.18
chr10_114552786_114553214	0.09	RP11-57H14.4		30249	0.21
chr7_70060715_70061143	0.09	AUTS2	autism susceptibility candidate 2	133196	0.06
chr6_165341863_165342014	0.09	C6orf118	chromosome 6 open reading frame 118	380404	0.01
chr4_160357796_160357947	0.09	ENSG00000251979	.	70309	0.12
chr12_6495821_6496120	0.09	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	1685	0.24
chr10_83897233_83897384	0.09	ENSG00000221378	.	87290	0.09
chr22_46929020_46929201	0.09	CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1	2081	0.33
chrX_24168685_24169495	0.09	ZFX	zinc finger protein, X-linked	789	0.52
chr12_117627018_117627293	0.09	FBXO21	F-box protein 21	936	0.7
chr4_169361832_169361983	0.09	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	15303	0.2
chr2_100591103_100591254	0.09	AFF3	AF4/FMR2 family, member 3	129814	0.05
chr16_77619617_77619768	0.09	ENSG00000221226	.	124506	0.05
chr5_115909245_115909579	0.09	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	679	0.82
chr11_13690121_13690272	0.09	FAR1	fatty acyl CoA reductase 1	21	0.94
chr14_78078422_78078640	0.08	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	4585	0.22
chr3_54674397_54674548	0.08	ESRG	embryonic stem cell related (non-protein coding)	588	0.86
chr11_66383426_66383834	0.08	RBM14	RNA binding motif protein 14	423	0.31
chr7_4046197_4046504	0.08	SDK1	sidekick cell adhesion molecule 1	55798	0.18
chr3_57578310_57578700	0.08	ARF4	ADP-ribosylation factor 4	4547	0.12
chr4_74571443_74571594	0.08	IL8	interleukin 8	34705	0.18
chr9_24036289_24036440	0.08	ELAVL2	ELAV like neuron-specific RNA binding protein 2	210029	0.03
chr14_89017580_89017758	0.08	PTPN21	protein tyrosine phosphatase, non-receptor type 21	135	0.68
chr19_57350948_57351186	0.08	PEG3	paternally expressed 3	997	0.38
chr19_13127591_13127981	0.08	CTC-239J10.1		2461	0.15
chr2_17997369_17997520	0.08	MSGN1	mesogenin 1	319	0.9
chr8_110619590_110619741	0.08	SYBU	syntabulin (syntaxin-interacting)	639	0.72
chr20_52211254_52212184	0.08	ZNF217	zinc finger protein 217	1341	0.45
chr4_152337049_152337200	0.08	FAM160A1	family with sequence similarity 160, member A1	6620	0.28
chr6_131948545_131949340	0.08	MED23	mediator complex subunit 23	258	0.77
chr17_4403572_4403723	0.08	AC118754.4		678	0.53
chr1_171220672_171220826	0.08	RP1-45C12.1		184	0.91
chr1_162532826_162532977	0.08	UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1	1578	0.3
chr14_70317063_70317281	0.08	SMOC1	SPARC related modular calcium binding 1	28961	0.17
chr3_158519414_158519896	0.08	MFSD1	major facilitator superfamily domain containing 1	1	0.54
chr6_26553804_26554291	0.08	HMGN4	high mobility group nucleosomal binding domain 4	15414	0.14
chr3_116583114_116583333	0.08	ENSG00000265433	.	14009	0.25
chr9_126770623_126770924	0.08	RP11-85O21.2		902	0.48
chrX_44401210_44401465	0.08	FUNDC1	FUN14 domain containing 1	910	0.68
chr7_99699979_99700130	0.08	AP4M1	adaptor-related protein complex 4, mu 1 subunit	370	0.46
chr5_114631582_114631761	0.08	CCDC112	coiled-coil domain containing 112	91	0.97
chr10_118534538_118534689	0.08	HSPA12A	heat shock 70kDa protein 12A	32528	0.17
chr2_62081759_62082202	0.08	FAM161A	family with sequence similarity 161, member A	702	0.69
chr12_30906652_30906803	0.08	CAPRIN2	caprin family member 2	518	0.86
chr1_244174827_244174978	0.08	ZBTB18	zinc finger and BTB domain containing 18	39683	0.17
chr12_54120989_54121200	0.08	CALCOCO1	calcium binding and coiled-coil domain 1	118	0.96
chr1_51796370_51796715	0.08	TTC39A	tetratricopeptide repeat domain 39A	77	0.95
chr4_146101952_146102435	0.08	OTUD4	OTU domain containing 4	880	0.65
chr2_178261408_178261672	0.08	AGPS	alkylglycerone phosphate synthase	4044	0.17
chr5_1887316_1887467	0.08	IRX4	iroquois homeobox 4	41	0.51

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.0	0.1	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0003171	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0072081	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.3	GO:0071805	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.1	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1	GO:0001527	microfibril(GO:0001527)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.4	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	GO:0035197	siRNA binding(GO:0035197)
0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	GO:0005521	lamin binding(GO:0005521)
0.0	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.0	REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	Genes involved in NGF signalling via TRKA from the plasma membrane