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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for NKX1-1

Z-value: 0.59

Motif logo

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_1397780_1397931NKX1-122640.2418660.627.7e-02Click!
chr4_1514830_1514981NKX1-11147860.0464130.511.6e-01Click!
chr4_1514451_1514602NKX1-11144070.0466490.481.9e-01Click!
chr4_1523235_1523394NKX1-11231950.0415500.343.7e-01Click!
chr4_1513980_1514175NKX1-11139580.046929-0.166.7e-01Click!

Activity of the NKX1-1 motif across conditions

Conditions sorted by the z-value of the NKX1-1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_196577911_196578299 0.33 KCNT2
 potassium channel, subfamily T, member 2
 250
 0.94
chr13_68202936_68203087 0.27 PCDH9
 protocadherin 9
 398543
 0.01
chr12_28124078_28124290 0.25 PTHLH
 parathyroid hormone-like hormone
 719
 0.71
chr2_101620301_101620452 0.24 RPL31
 ribosomal protein L31
 1175
 0.38
chr4_83810146_83810528 0.23 SEC31A
 SEC31 homolog A (S. cerevisiae)
 1834
 0.28
chr6_117804579_117805184 0.23 DCBLD1
 discoidin, CUB and LCCL domain containing 1
 1056
 0.49
chr1_23494434_23494599 0.23 LUZP1
 leucine zipper protein 1
 794
 0.54
chr9_13278507_13279169 0.22 RP11-272P10.2
348
 0.67
chr4_89522534_89522685 0.22 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 4336
 0.21
chr4_157891142_157892336 0.21 PDGFC
 platelet derived growth factor C
 316
 0.91
chr6_27263961_27264170 0.20 POM121L2
 POM121 transmembrane nucleoporin-like 2
 15026
 0.2
chr5_57752049_57752200 0.20 PLK2
 polo-like kinase 2
 3963
 0.27
chr16_13401641_13401792 0.19 AC003009.1
24724
 0.26
chr7_80513051_80513202 0.19 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 35373
 0.24
chr21_16435398_16436179 0.18 NRIP1
 nuclear receptor interacting protein 1
 1338
 0.57
chr22_46476561_46476775 0.18 FLJ27365
 hsa-mir-4763
 476
 0.66
chr17_35289223_35289419 0.18 RP11-445F12.1
4600
 0.15
chr5_180529470_180529621 0.18 OR2V1
 olfactory receptor, family 2, subfamily V, member 1
 22759
 0.13
chr6_136888235_136888386 0.18 MAP7
 microtubule-associated protein 7
 16353
 0.15
chr20_43965593_43965922 0.18 SDC4
 syndecan 4
 11307
 0.11
chr10_102760785_102760994 0.17 LZTS2
 leucine zipper, putative tumor suppressor 2
 1279
 0.27
chrX_25020829_25021251 0.17 ARX
 aristaless related homeobox
 13025
 0.26
chr9_72745702_72745853 0.17 MAMDC2-AS1
 MAMDC2 antisense RNA 1
 17001
 0.22
chr15_70384069_70384220 0.17 TLE3
 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
 2980
 0.31
chr11_122049732_122050124 0.17 ENSG00000207994
 .
 26912
 0.16
chr18_20612011_20612377 0.17 ENSG00000223023
 .
 7635
 0.17
chr21_27778313_27779012 0.17 AP001597.1
400
 0.89
chr8_94507892_94508285 0.16 ENSG00000222416
 .
 54583
 0.14
chr5_180523773_180523999 0.16 OR2V1
 olfactory receptor, family 2, subfamily V, member 1
 28418
 0.12
chr12_115120620_115120912 0.16 TBX3
 T-box 3
 629
 0.77
chr2_163171316_163171467 0.16 IFIH1
 interferon induced with helicase C domain 1
 3803
 0.25
chr12_53896533_53896684 0.16 TARBP2
 TAR (HIV-1) RNA binding protein 2
 773
 0.43
chr2_163157606_163157781 0.16 IFIH1
 interferon induced with helicase C domain 1
 17501
 0.19
chr14_62032902_62033075 0.16 RP11-47I22.3
 Uncharacterized protein
 4326
 0.24
chr1_109741279_109741478 0.16 ENSG00000238310
 .
 9092
 0.15
chr10_131555251_131555402 0.15 RP11-109A6.2
55505
 0.15
chr18_59619337_59619488 0.15 RNF152
 ring finger protein 152
 57948
 0.16
chr6_27263399_27263763 0.15 POM121L2
 POM121 transmembrane nucleoporin-like 2
 15510
 0.2
chr6_49794571_49794884 0.15 RP3-417L20.4
9584
 0.19
chr17_41668751_41668949 0.15 ETV4
 ets variant 4
 11862
 0.16
chr4_186768313_186768795 0.14 SORBS2
 sorbin and SH3 domain containing 2
 34276
 0.19
chr14_103058041_103058305 0.14 RCOR1
 REST corepressor 1
 825
 0.6
chr15_69367071_69367289 0.14 RP11-809H16.4
31275
 0.17
chr4_75550401_75550552 0.14 AC142293.3
35812
 0.18
chr10_30347491_30347726 0.14 KIAA1462
 KIAA1462
 845
 0.76
chr13_114599987_114600138 0.14 GAS6
 growth arrest-specific 6
 33016
 0.2
chr6_37210883_37211034 0.14 ENSG00000238375
 .
 8124
 0.16
chr11_12716213_12716424 0.14 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 19268
 0.26
chr1_45826795_45827032 0.14 ENSG00000238945
 .
 2493
 0.23
chr8_334889_335040 0.14 FBXO25
 F-box protein 25
 21464
 0.22
chr6_41472777_41473161 0.14 RP11-328M4.2
40843
 0.13
chr4_31656800_31656951 0.14 RP11-619J20.1
861283
 0.0
chr15_67334428_67334662 0.14 SMAD3
 SMAD family member 3
 21556
 0.25
chr5_172665530_172665713 0.14 NKX2-5
 NK2 homeobox 5
 3261
 0.23
chr4_1005974_1006310 0.13 FGFRL1
 fibroblast growth factor receptor-like 1
 97
 0.95
chr4_163496269_163496420 0.13 FSTL5
 follistatin-like 5
 411157
 0.01
chr9_133711223_133711921 0.13 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 1119
 0.56
chr3_79417981_79418132 0.13 ENSG00000265193
 .
 138981
 0.05
chr16_19606642_19606793 0.13 C16orf62
 chromosome 16 open reading frame 62
 12381
 0.18
chr11_94661378_94661529 0.13 RP11-856F16.2
2767
 0.3
chr19_4402510_4402661 0.13 CHAF1A
 chromatin assembly factor 1, subunit A (p150)
 74
 0.93
chr2_63815441_63815904 0.13 WDPCP
 WD repeat containing planar cell polarity effector
 20
 0.54
chr5_127874204_127874722 0.13 FBN2
 fibrillin 2
 547
 0.58
chr14_93552039_93552233 0.13 ITPK1-AS1
 ITPK1 antisense RNA 1
 18339
 0.18
chr19_2962281_2962480 0.13 TLE6
 transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
 15064
 0.12
chr8_29200137_29200318 0.13 DUSP4
 dual specificity phosphatase 4
 6095
 0.17
chr2_188418561_188419245 0.13 AC007319.1
27
 0.69
chr2_242256486_242256668 0.12 HDLBP
 high density lipoprotein binding protein
 101
 0.93
chr8_98880755_98880906 0.12 MATN2
 matrilin 2
 238
 0.95
chr8_124284035_124284186 0.12 ZHX1
 zinc fingers and homeoboxes 1
 2437
 0.16
chr16_85202371_85202571 0.12 CTC-786C10.1
2411
 0.35
chr11_95646755_95646928 0.12 MTMR2
 myotubularin related protein 2
 600
 0.82
chr6_62996046_62996197 0.12 KHDRBS2
 KH domain containing, RNA binding, signal transduction associated 2
 11
 0.99
chr7_63385679_63385830 0.12 ENSG00000265017
 .
 1460
 0.47
chr8_126323291_126323442 0.12 RP11-550A5.2
40292
 0.16
chr1_206593163_206593314 0.12 SRGAP2
 SLIT-ROBO Rho GTPase activating protein 2
 13502
 0.18
chr6_165341311_165341481 0.12 C6orf118
 chromosome 6 open reading frame 118
 380946
 0.01
chr13_26043049_26043230 0.12 ATP8A2
 ATPase, aminophospholipid transporter, class I, type 8A, member 2
 26
 0.98
chr12_42875750_42875901 0.12 PRICKLE1
 prickle homolog 1 (Drosophila)
 1049
 0.48
chr9_110400275_110400607 0.12 ENSG00000202308
 .
 25086
 0.24
chr14_91091040_91091191 0.12 TTC7B
 tetratricopeptide repeat domain 7B
 6748
 0.2
chr8_124195558_124195709 0.11 RP11-539E17.5
605
 0.42
chr1_115258427_115259019 0.11 NRAS
 neuroblastoma RAS viral (v-ras) oncogene homolog
 792
 0.54
chr5_174178214_174178699 0.11 ENSG00000266890
 .
 281
 0.94
chr8_36807823_36808005 0.11 KCNU1
 potassium channel, subfamily U, member 1
 21491
 0.29
chr3_154797621_154798368 0.11 MME
 membrane metallo-endopeptidase
 94
 0.98
chr17_47547430_47548013 0.11 NGFR
 nerve growth factor receptor
 24934
 0.13
chr3_159483781_159484285 0.11 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1141
 0.44
chr9_82795299_82795450 0.11 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 473693
 0.01
chr2_5837836_5837987 0.11 SOX11
 SRY (sex determining region Y)-box 11
 5112
 0.22
chr4_66536403_66536611 0.11 EPHA5
 EPH receptor A5
 294
 0.95
chr13_106426830_106427002 0.11 ENSG00000252550
 .
 123076
 0.06
chr4_75858398_75858601 0.11 PARM1
 prostate androgen-regulated mucin-like protein 1
 173
 0.97
chr6_47666951_47667231 0.11 GPR115
 G protein-coupled receptor 115
 802
 0.64
chr10_105559478_105559629 0.11 SH3PXD2A
 SH3 and PX domains 2A
 1502
 0.47
chr18_77662426_77662577 0.11 KCNG2
 potassium voltage-gated channel, subfamily G, member 2
 38833
 0.15
chr15_33323538_33323689 0.11 FMN1
 formin 1
 36472
 0.19
chr10_119302142_119302346 0.11 EMX2
 empty spiracles homeobox 2
 265
 0.64
chr11_2834821_2835116 0.11 KCNQ1-AS1
 KCNQ1 antisense RNA 1
 47830
 0.11
chr6_7312252_7312483 0.11 SSR1
 signal sequence receptor, alpha
 1040
 0.57
chr12_59314342_59314656 0.11 RP11-150C16.1
79
 0.67
chr13_53192037_53192369 0.10 HNRNPA1L2
 heterogeneous nuclear ribonucleoprotein A1-like 2
 598
 0.79
chr13_107160462_107160937 0.10 EFNB2
 ephrin-B2
 26763
 0.24
chr2_44935412_44935824 0.10 ENSG00000252896
 .
 73651
 0.12
chr14_76604893_76605206 0.10 GPATCH2L
 G patch domain containing 2-like
 13213
 0.26
chr5_102897969_102898137 0.10 NUDT12
 nudix (nucleoside diphosphate linked moiety X)-type motif 12
 437
 0.91
chr3_16024121_16024347 0.10 ENSG00000207815
 .
 108956
 0.06
chr10_6763782_6764322 0.10 PRKCQ
 protein kinase C, theta
 141789
 0.05
chr2_8135764_8135915 0.10 ENSG00000221255
 .
 418867
 0.01
chr5_36951473_36951624 0.10 NIPBL
 Nipped-B homolog (Drosophila)
 74656
 0.12
chr7_132088071_132088231 0.10 AC011625.1
51058
 0.17
chr11_105892671_105892946 0.10 MSANTD4
 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
 146
 0.96
chr1_146641853_146642189 0.10 PRKAB2
 protein kinase, AMP-activated, beta 2 non-catalytic subunit
 2025
 0.25
chr6_136887685_136887836 0.10 MAP7
 microtubule-associated protein 7
 15803
 0.16
chr6_26312991_26313348 0.10 HIST1H4H
 histone cluster 1, H4h
 27407
 0.07
chr2_5619821_5619972 0.10 AC108025.2
211282
 0.02
chr11_16809886_16810037 0.10 PLEKHA7
 pleckstrin homology domain containing, family A member 7
 24069
 0.19
chr11_117778647_117778798 0.10 TMPRSS13
 transmembrane protease, serine 13
 21358
 0.14
chr1_2461773_2461924 0.10 HES5
 hes family bHLH transcription factor 5
 164
 0.9
chr1_226109753_226109904 0.10 PYCR2
 pyrroline-5-carboxylate reductase family, member 2
 2131
 0.19
chr7_32929941_32930760 0.10 KBTBD2
 kelch repeat and BTB (POZ) domain containing 2
 415
 0.87
chr10_17547257_17547425 0.10 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 51012
 0.13
chr11_109294220_109294371 0.10 C11orf87
 chromosome 11 open reading frame 87
 1449
 0.58
chr1_209975427_209975724 0.10 IRF6
 interferon regulatory factor 6
 64
 0.96
chr9_13278250_13278433 0.10 RP11-272P10.2
845
 0.51
chr14_42609890_42610041 0.10 ENSG00000222084
 .
 159989
 0.04
chr19_4343203_4343398 0.10 MPND
 MPN domain containing
 224
 0.83
chr20_10502111_10502382 0.09 SLX4IP
 SLX4 interacting protein
 86295
 0.09
chr8_80696427_80696819 0.09 ENSG00000238884
 .
 15807
 0.22
chr15_41274840_41275069 0.09 RP11-540O11.6
16518
 0.12
chr17_40574158_40574426 0.09 PTRF
 polymerase I and transcript release factor
 1243
 0.31
chr12_17033936_17034087 0.09 ENSG00000212358
 .
 190428
 0.03
chr10_12746098_12746480 0.09 ENSG00000221331
 .
 21063
 0.25
chr8_31771478_31771629 0.09 NRG1-IT1
 NRG1 intronic transcript 1 (non-protein coding)
 112182
 0.07
chr15_31690130_31690281 0.09 KLF13
 Kruppel-like factor 13
 31848
 0.24
chr15_96870341_96870527 0.09 NR2F2-AS1
 NR2F2 antisense RNA 1
 89
 0.95
chr3_170527527_170527678 0.09 ENSG00000222411
 .
 32359
 0.19
chr5_36873918_36874176 0.09 NIPBL
 Nipped-B homolog (Drosophila)
 2814
 0.4
chr10_44277299_44277450 0.09 ZNF32
 zinc finger protein 32
 133070
 0.05
chr3_171848594_171848745 0.09 FNDC3B
 fibronectin type III domain containing 3B
 3905
 0.33
chr2_216876893_216877044 0.09 MREG
 melanoregulin
 1378
 0.5
chr5_36842382_36842533 0.09 NIPBL
 Nipped-B homolog (Drosophila)
 34404
 0.22
chr13_37006714_37007207 0.09 CCNA1
 cyclin A1
 465
 0.85
chr5_82767889_82768074 0.09 VCAN
 versican
 237
 0.96
chr15_43576768_43576919 0.09 RP11-402F9.3
17451
 0.1
chr7_29603770_29603921 0.09 PRR15
 proline rich 15
 418
 0.58
chrX_45482024_45482567 0.09 ENSG00000207870
 .
 123399
 0.06
chr7_70596624_70596819 0.09 WBSCR17
 Williams-Beuren syndrome chromosome region 17
 434
 0.91
chr8_37915323_37915474 0.09 KB-1836B5.1
5001
 0.15
chr19_37743129_37743340 0.09 ZNF383
 zinc finger protein 383
 24782
 0.13
chr12_70381241_70381594 0.09 RP11-611E13.3
40556
 0.18
chr10_114552786_114553214 0.09 RP11-57H14.4
30249
 0.21
chr7_70060715_70061143 0.09 AUTS2
 autism susceptibility candidate 2
 133196
 0.06
chr6_165341863_165342014 0.09 C6orf118
 chromosome 6 open reading frame 118
 380404
 0.01
chr4_160357796_160357947 0.09 ENSG00000251979
 .
 70309
 0.12
chr12_6495821_6496120 0.09 LTBR
 lymphotoxin beta receptor (TNFR superfamily, member 3)
 1685
 0.24
chr10_83897233_83897384 0.09 ENSG00000221378
 .
 87290
 0.09
chr22_46929020_46929201 0.09 CELSR1
 cadherin, EGF LAG seven-pass G-type receptor 1
 2081
 0.33
chrX_24168685_24169495 0.09 ZFX
 zinc finger protein, X-linked
 789
 0.52
chr12_117627018_117627293 0.09 FBXO21
 F-box protein 21
 936
 0.7
chr4_169361832_169361983 0.09 DDX60L
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
 15303
 0.2
chr2_100591103_100591254 0.09 AFF3
 AF4/FMR2 family, member 3
 129814
 0.05
chr16_77619617_77619768 0.09 ENSG00000221226
 .
 124506
 0.05
chr5_115909245_115909579 0.09 SEMA6A
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
 679
 0.82
chr11_13690121_13690272 0.09 FAR1
 fatty acyl CoA reductase 1
 21
 0.94
chr14_78078422_78078640 0.08 SPTLC2
 serine palmitoyltransferase, long chain base subunit 2
 4585
 0.22
chr3_54674397_54674548 0.08 ESRG
 embryonic stem cell related (non-protein coding)
 588
 0.86
chr11_66383426_66383834 0.08 RBM14
 RNA binding motif protein 14
 423
 0.31
chr7_4046197_4046504 0.08 SDK1
 sidekick cell adhesion molecule 1
 55798
 0.18
chr3_57578310_57578700 0.08 ARF4
 ADP-ribosylation factor 4
 4547
 0.12
chr4_74571443_74571594 0.08 IL8
 interleukin 8
 34705
 0.18
chr9_24036289_24036440 0.08 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
 210029
 0.03
chr14_89017580_89017758 0.08 PTPN21
 protein tyrosine phosphatase, non-receptor type 21
 135
 0.68
chr19_57350948_57351186 0.08 PEG3
 paternally expressed 3
 997
 0.38
chr19_13127591_13127981 0.08 CTC-239J10.1
2461
 0.15
chr2_17997369_17997520 0.08 MSGN1
 mesogenin 1
 319
 0.9
chr8_110619590_110619741 0.08 SYBU
 syntabulin (syntaxin-interacting)
 639
 0.72
chr20_52211254_52212184 0.08 ZNF217
 zinc finger protein 217
 1341
 0.45
chr4_152337049_152337200 0.08 FAM160A1
 family with sequence similarity 160, member A1
 6620
 0.28
chr6_131948545_131949340 0.08 MED23
 mediator complex subunit 23
 258
 0.77
chr17_4403572_4403723 0.08 AC118754.4
678
 0.53
chr1_171220672_171220826 0.08 RP1-45C12.1
184
 0.91
chr1_162532826_162532977 0.08 UAP1
 UDP-N-acteylglucosamine pyrophosphorylase 1
 1578
 0.3
chr14_70317063_70317281 0.08 SMOC1
 SPARC related modular calcium binding 1
 28961
 0.17
chr3_158519414_158519896 0.08 MFSD1
 major facilitator superfamily domain containing 1
 1
 0.54
chr6_26553804_26554291 0.08 HMGN4
 high mobility group nucleosomal binding domain 4
 15414
 0.14
chr3_116583114_116583333 0.08 ENSG00000265433
 .
 14009
 0.25
chr9_126770623_126770924 0.08 RP11-85O21.2
902
 0.48
chrX_44401210_44401465 0.08 FUNDC1
 FUN14 domain containing 1
 910
 0.68
chr7_99699979_99700130 0.08 AP4M1
 adaptor-related protein complex 4, mu 1 subunit
 370
 0.46
chr5_114631582_114631761 0.08 CCDC112
 coiled-coil domain containing 112
 91
 0.97
chr10_118534538_118534689 0.08 HSPA12A
 heat shock 70kDa protein 12A
 32528
 0.17
chr2_62081759_62082202 0.08 FAM161A
 family with sequence similarity 161, member A
 702
 0.69
chr12_30906652_30906803 0.08 CAPRIN2
 caprin family member 2
 518
 0.86
chr1_244174827_244174978 0.08 ZBTB18
 zinc finger and BTB domain containing 18
 39683
 0.17
chr12_54120989_54121200 0.08 CALCOCO1
 calcium binding and coiled-coil domain 1
 118
 0.96
chr1_51796370_51796715 0.08 TTC39A
 tetratricopeptide repeat domain 39A
 77
 0.95
chr4_146101952_146102435 0.08 OTUD4
 OTU domain containing 4
 880
 0.65
chr2_178261408_178261672 0.08 AGPS
 alkylglycerone phosphate synthase
 4044
 0.17
chr5_1887316_1887467 0.08 IRX4
 iroquois homeobox 4
 41
 0.51

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0003171 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.0 GO:0060197 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.0 GO:0009296 obsolete flagellum assembly(GO:0009296)
0.0 0.1 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.0 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.0 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.0 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:1904358 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0001527 microfibril(GO:0001527)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.0 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.0 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane