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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX2-2

Z-value: 1.19

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Transcription factors associated with NKX2-2

Gene Symbol	Gene ID	Gene Info
NKX2-2 Ensembl NCBI GeneCards UniProt	ENSG00000125820.5	NKX2-2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX2-2	chr20_21501454_21501605	6865	0.225083	0.67	4.7e-02	Click!
NKX2-2	chr20_21528926_21529077	34337	0.176605	-0.55	1.3e-01	Click!
NKX2-2	chr20_21538382_21538533	43793	0.157380	-0.51	1.6e-01	Click!
NKX2-2	chr20_21538130_21538281	43541	0.157894	-0.45	2.3e-01	Click!
NKX2-2	chr20_21495239_21495416	663	0.719751	-0.24	5.4e-01	Click!

Activity of the NKX2-2 motif across conditions

Conditions sorted by the z-value of the NKX2-2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_118745072_118745584	0.67	TAOK3	TAO kinase 3	51464	0.15
chr5_39423780_39424080	0.66	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	1040	0.66
chr1_224805949_224806359	0.48	CNIH3	cornichon family AMPA receptor auxiliary protein 3	2159	0.29
chr7_77930640_77930829	0.47	RP5-1185I7.1		310997	0.01
chr1_158969828_158970040	0.45	IFI16	interferon, gamma-inducible protein 16	176	0.96
chr1_218672576_218672996	0.44	C1orf143	chromosome 1 open reading frame 143	10652	0.26
chr6_56707059_56707245	0.43	DST	dystonin	791	0.6
chr14_33045621_33045875	0.42	AKAP6	A kinase (PRKA) anchor protein 6	81470	0.11
chr3_8809480_8810320	0.42	OXTR	oxytocin receptor	463	0.76
chr1_156091066_156091427	0.40	LMNA	lamin A/C	4705	0.12
chr7_94027358_94027511	0.39	COL1A2	collagen, type I, alpha 2	3561	0.34
chr4_4494063_4494282	0.39	STX18-IT1	STX18 intronic transcript 1 (non-protein coding)	10745	0.21
chr12_91573704_91574005	0.38	DCN	decorin	288	0.94
chr1_164532131_164532342	0.38	PBX1	pre-B-cell leukemia homeobox 1	194	0.97
chr13_77457508_77457742	0.37	KCTD12	potassium channel tetramerization domain containing 12	2900	0.26
chr3_132316198_132316509	0.37	ACKR4	atypical chemokine receptor 4	272	0.93
chr7_17030060_17030455	0.37	AGR3	anterior gradient 3	108646	0.07
chr3_132315920_132316071	0.37	ACKR4	atypical chemokine receptor 4	86	0.98
chr2_188312053_188312458	0.36	CALCRL	calcitonin receptor-like	724	0.77
chr19_16403865_16404198	0.36	CTD-2562J15.6		355	0.85
chr14_81866312_81866672	0.36	STON2	stonin 2	1565	0.55
chr11_121968562_121968780	0.35	ENSG00000207971	.	1881	0.27
chr5_72147028_72147179	0.35	TNPO1	transportin 1	3092	0.26
chr5_98118231_98118548	0.35	RGMB	repulsive guidance molecule family member b	9050	0.23
chr9_2838300_2838770	0.35	KIAA0020	KIAA0020	5706	0.3
chr13_76020093_76020271	0.35	TBC1D4	TBC1 domain family, member 4	36068	0.18
chr1_101359369_101359680	0.35	EXTL2	exostosin-like glycosyltransferase 2	696	0.48
chr2_66664825_66665240	0.35	MEIS1	Meis homeobox 1	93	0.96
chr13_95255061_95255225	0.34	GPR180	G protein-coupled receptor 180	986	0.56
chr4_81191707_81191903	0.34	FGF5	fibroblast growth factor 5	4012	0.29
chr4_119948824_119949052	0.34	SYNPO2	synaptopodin 2	4312	0.32
chr11_101983358_101983513	0.34	YAP1	Yes-associated protein 1	190	0.94
chr11_121969171_121969347	0.34	ENSG00000207971	.	1293	0.36
chr4_151062450_151062706	0.33	DCLK2	doublecortin-like kinase 2	62398	0.13
chr12_94761705_94761856	0.33	ENSG00000244391	.	6784	0.22
chr20_17538596_17539086	0.33	BFSP1	beaded filament structural protein 1, filensin	642	0.72
chr5_52136022_52136457	0.33	CTD-2288O8.1		52379	0.13
chr2_175203994_175204145	0.33	AC018470.1	Uncharacterized protein FLJ46347	1918	0.29
chr11_120195755_120196855	0.33	TMEM136	transmembrane protein 136	289	0.9
chr11_74494468_74494674	0.32	ENSG00000264095	.	29942	0.12
chr20_46121886_46122388	0.32	ENSG00000201742	.	308	0.88
chr12_56916774_56917003	0.32	RBMS2	RNA binding motif, single stranded interacting protein 2	1105	0.41
chr1_178269315_178269642	0.32	RASAL2	RAS protein activator like 2	41128	0.2
chr1_119524620_119524878	0.32	TBX15	T-box 15	5679	0.29
chr2_53803027_53803274	0.32	ENSG00000207456	.	5533	0.28
chr1_89197420_89197765	0.31	PKN2	protein kinase N2	39546	0.16
chr1_179111271_179111703	0.31	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	692	0.72
chr7_91923432_91923918	0.31	ANKIB1	ankyrin repeat and IBR domain containing 1	101	0.97
chr9_110248378_110248529	0.31	KLF4	Kruppel-like factor 4 (gut)	2958	0.29
chr3_185741982_185742377	0.31	ENSG00000266670	.	42096	0.14
chr9_73539563_73539988	0.31	TRPM3	transient receptor potential cation channel, subfamily M, member 3	55801	0.16
chr14_59949074_59949274	0.31	L3HYPDH	L-3-hydroxyproline dehydratase (trans-)	1229	0.4
chr18_52919735_52919886	0.31	TCF4	transcription factor 4	23092	0.25
chr18_34252707_34252889	0.31	ENSG00000252078	.	30151	0.2
chr10_15546629_15546846	0.31	FAM171A1	family with sequence similarity 171, member A1	133676	0.05
chr6_116833589_116833880	0.30	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr8_105236286_105236489	0.30	RIMS2	regulating synaptic membrane exocytosis 2	507	0.87
chr8_49447973_49448420	0.30	RP11-770E5.1		15931	0.3
chr3_145968034_145968185	0.30	PLSCR4	phospholipid scramblase 4	545	0.85
chr1_96354702_96354941	0.30	ENSG00000221798	.	2725	0.41
chr13_80824494_80824698	0.29	SPRY2	sprouty homolog 2 (Drosophila)	89198	0.1
chr6_132452290_132452699	0.29	ENSG00000265669	.	16091	0.27
chr14_52821800_52821992	0.29	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	40783	0.18
chr3_114369992_114370143	0.29	ZBTB20	zinc finger and BTB domain containing 20	26275	0.25
chr6_161649839_161650239	0.29	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	45012	0.2
chr21_47404119_47404503	0.29	COL6A1	collagen, type VI, alpha 1	2660	0.29
chr5_54456456_54456818	0.29	GPX8	glutathione peroxidase 8 (putative)	639	0.58
chr12_88810686_88810837	0.28	ENSG00000199245	.	13458	0.29
chr8_117466815_117467042	0.28	ENSG00000264815	.	167340	0.04
chr1_200710499_200710966	0.28	CAMSAP2	calmodulin regulated spectrin-associated protein family, member 2	1825	0.44
chr5_44389781_44390058	0.28	FGF10	fibroblast growth factor 10	111	0.95
chr12_19284782_19284948	0.28	PLEKHA5	pleckstrin homology domain containing, family A member 5	2135	0.35
chr11_46300696_46300847	0.28	CREB3L1	cAMP responsive element binding protein 3-like 1	1543	0.37
chr17_21163251_21163402	0.28	C17orf103	chromosome 17 open reading frame 103	6604	0.17
chrX_114849372_114849580	0.28	PLS3	plastin 3	4921	0.25
chr2_198539715_198539970	0.28	RFTN2	raftlin family member 2	877	0.6
chr10_76050173_76050375	0.28	ADK	adenosine kinase	113753	0.06
chr8_38857241_38857490	0.28	ADAM9	ADAM metallopeptidase domain 9	2860	0.19
chr8_116264905_116265143	0.27	TRPS1	trichorhinophalangeal syndrome I	239424	0.02
chr2_153348906_153349057	0.27	FMNL2	formin-like 2	127111	0.06
chr13_101202740_101202924	0.27	RP11-151A6.4		10772	0.19
chr6_139692941_139693119	0.27	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	2320	0.4
chr6_152701268_152701555	0.27	SYNE1-AS1	SYNE1 antisense RNA 1	270	0.91
chr7_56160445_56160611	0.27	PHKG1	phosphorylase kinase, gamma 1 (muscle)	97	0.94
chr3_146755933_146756085	0.27	ENSG00000207156	.	41509	0.2
chr2_163099691_163099877	0.27	FAP	fibroblast activation protein, alpha	182	0.96
chr3_159483781_159484285	0.27	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr5_55420029_55420180	0.27	ENSG00000253032	.	1394	0.4
chr1_198057970_198058261	0.27	NEK7	NIMA-related kinase 7	67978	0.13
chr2_159610172_159610621	0.27	AC005042.4		18882	0.21
chr4_170188672_170188986	0.26	SH3RF1	SH3 domain containing ring finger 1	2279	0.41
chr4_87052385_87052536	0.26	RP11-778J15.1		11593	0.23
chr3_145877576_145877727	0.26	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	1128	0.57
chr5_141920833_141921059	0.26	ENSG00000252831	.	7036	0.25
chr4_114899439_114899761	0.26	ARSJ	arylsulfatase family, member J	552	0.84
chr15_49758482_49758645	0.26	FGF7	fibroblast growth factor 7	43106	0.17
chr2_220942198_220942388	0.26	ENSG00000221199	.	114306	0.06
chr3_73159675_73159826	0.26	ENSG00000223247	.	393	0.83
chr18_6030976_6031127	0.26	RP11-793A3.2		5961	0.23
chr9_91929257_91929464	0.26	ENSG00000265112	.	2220	0.26
chr18_7579845_7579996	0.26	PTPRM	protein tyrosine phosphatase, receptor type, M	12103	0.29
chr2_171700467_171700658	0.26	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	21965	0.15
chr10_96163775_96164021	0.26	TBC1D12	TBC1 domain family, member 12	1637	0.43
chr13_32786329_32786590	0.26	FRY	furry homolog (Drosophila)	52346	0.14
chr14_90126270_90126545	0.26	ENSG00000252655	.	9160	0.16
chr1_51438505_51438667	0.25	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	2970	0.28
chr2_169374767_169374972	0.25	CERS6	ceramide synthase 6	62110	0.1
chr8_99740073_99740224	0.25	STK3	serine/threonine kinase 3	97751	0.08
chr7_27236053_27236457	0.25	HOTTIP	HOXA distal transcript antisense RNA	1939	0.13
chr9_21591325_21591685	0.25	MIR31HG	MIR31 host gene (non-protein coding)	31837	0.16
chr1_214618329_214618746	0.25	PTPN14	protein tyrosine phosphatase, non-receptor type 14	19609	0.26
chr15_36623332_36623712	0.25	C15orf41	chromosome 15 open reading frame 41	248290	0.02
chr5_43308499_43308850	0.25	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	4652	0.23
chr12_116037117_116037430	0.25	ENSG00000240205	.	118257	0.07
chr18_46020104_46020474	0.25	ENSG00000200872	.	18318	0.21
chr7_18549761_18549974	0.25	HDAC9	histone deacetylase 9	931	0.71
chr6_40687581_40687836	0.25	LRFN2	leucine rich repeat and fibronectin type III domain containing 2	132504	0.05
chr11_48039463_48039614	0.25	AC103828.1		2131	0.35
chr2_8143991_8144314	0.24	ENSG00000221255	.	427180	0.01
chr17_31239173_31239327	0.24	TMEM98	transmembrane protein 98	15678	0.17
chr10_95196659_95197038	0.24	MYOF	myoferlin	45103	0.14
chr1_13910795_13911459	0.24	PDPN	podoplanin	362	0.87
chr2_38373660_38374056	0.24	ENSG00000199603	.	699	0.72
chr13_35963746_35963897	0.24	MAB21L1	mab-21-like 1 (C. elegans)	87011	0.09
chr4_116464375_116464526	0.24	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	429418	0.01
chr3_157154723_157155399	0.24	PTX3	pentraxin 3, long	483	0.86
chr1_167693043_167693194	0.24	MPZL1	myelin protein zero-like 1	1729	0.44
chr7_129850493_129850759	0.24	SSMEM1	serine-rich single-pass membrane protein 1	2926	0.19
chr13_80066771_80066922	0.24	NDFIP2	Nedd4 family interacting protein 2	11258	0.21
chr2_18595221_18595519	0.24	RDH14	retinol dehydrogenase 14 (all-trans/9-cis/11-cis)	146576	0.04
chr15_71504267_71504460	0.24	RP11-673C5.2		22982	0.23
chr4_175055764_175055915	0.24	FBXO8	F-box protein 8	148975	0.04
chr3_25193430_25193657	0.24	RARB	retinoic acid receptor, beta	22280	0.26
chr11_10229350_10229501	0.23	RP11-748C4.1		58686	0.12
chr7_77388461_77388692	0.23	RSBN1L	round spermatid basic protein 1-like	336	0.9
chr14_69709628_69709779	0.23	GALNT16	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16	16978	0.2
chr1_101334241_101334590	0.23	EXTL2	exostosin-like glycosyltransferase 2	25805	0.15
chr1_55701423_55701577	0.23	ENSG00000265822	.	10186	0.23
chr18_12306690_12306841	0.23	TUBB6	tubulin, beta 6 class V	903	0.54
chr5_95403437_95403808	0.23	ENSG00000207578	.	11220	0.25
chr12_91092431_91092582	0.23	CCER1	coiled-coil glutamate-rich protein 1	256447	0.02
chr5_39421239_39421390	0.23	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	3656	0.34
chr7_120632569_120632731	0.23	CPED1	cadherin-like and PC-esterase domain containing 1	2974	0.27
chr2_161274557_161274766	0.23	RBMS1	RNA binding motif, single stranded interacting protein 1	1972	0.35
chr3_127633934_127634403	0.23	KBTBD12	kelch repeat and BTB (POZ) domain containing 12	93	0.98
chrX_105951632_105951877	0.23	RNF128	ring finger protein 128, E3 ubiquitin protein ligase	14686	0.24
chr5_142880921_142881072	0.23	ENSG00000253023	.	41156	0.18
chr4_83996791_83996942	0.23	PLAC8	placenta-specific 8	34130	0.14
chr16_27256849_27257000	0.23	NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	12525	0.16
chr4_99544258_99544409	0.23	TSPAN5	tetraspanin 5	34453	0.18
chr10_13754786_13755077	0.23	RP11-295P9.6		2516	0.19
chr5_95068939_95069254	0.23	CTD-2154I11.2		1097	0.44
chr11_14375529_14375805	0.23	RRAS2	related RAS viral (r-ras) oncogene homolog 2	379	0.91
chr1_178064247_178064419	0.23	RASAL2	RAS protein activator like 2	1057	0.69
chrX_102940107_102940387	0.23	MORF4L2	mortality factor 4 like 2	902	0.43
chr15_96878465_96878729	0.22	ENSG00000222651	.	2107	0.24
chr8_19148668_19149118	0.22	SH2D4A	SH2 domain containing 4A	22235	0.28
chr1_218550498_218550696	0.22	TGFB2	transforming growth factor, beta 2	31020	0.18
chr1_203631994_203632193	0.22	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	19844	0.21
chr5_171269419_171269604	0.22	SMIM23	small integral membrane protein 23	56621	0.13
chr6_136809157_136809308	0.22	MAP7	microtubule-associated protein 7	21219	0.2
chr2_225276641_225276966	0.22	FAM124B	family with sequence similarity 124B	10001	0.29
chr4_81177063_81177214	0.22	FGF5	fibroblast growth factor 5	10615	0.24
chr3_130648403_130648554	0.22	RP11-39E3.3		342	0.49
chr13_50650646_50650797	0.22	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	5586	0.18
chr7_75984582_75984890	0.22	YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma	3612	0.2
chr10_54357540_54357691	0.22	RP11-556E13.1		36750	0.23
chr11_33746911_33747062	0.22	CD59	CD59 molecule, complement regulatory protein	2488	0.23
chr9_5518498_5518649	0.22	PDCD1LG2	programmed cell death 1 ligand 2	8003	0.25
chr3_167780902_167781122	0.22	GOLIM4	golgi integral membrane protein 4	32120	0.24
chr8_41862770_41862921	0.22	ENSG00000238966	.	38248	0.15
chr19_7581346_7582140	0.22	ZNF358	zinc finger protein 358	739	0.45
chr7_130602252_130602403	0.22	ENSG00000226380	.	40029	0.17
chr12_63702500_63702651	0.22	AVPR1A	arginine vasopressin receptor 1A	157853	0.04
chr5_82354364_82354515	0.22	ENSG00000238835	.	5717	0.23
chr9_21968288_21968979	0.22	C9orf53	chromosome 9 open reading frame 53	1496	0.32
chr3_99591263_99591414	0.21	FILIP1L	filamin A interacting protein 1-like	3610	0.31
chr3_57094343_57094529	0.21	SPATA12	spermatogenesis associated 12	33	0.98
chr7_143155212_143155383	0.21	TAS2R60	taste receptor, type 2, member 60	14751	0.13
chr9_97811962_97812255	0.21	ENSG00000207563	.	35382	0.12
chr8_128003605_128003873	0.21	ENSG00000212451	.	319972	0.01
chr9_96932852_96933003	0.21	ENSG00000199165	.	5307	0.17
chr10_128993776_128993991	0.21	FAM196A	family with sequence similarity 196, member A	539	0.87
chr4_86397366_86397517	0.21	ARHGAP24	Rho GTPase activating protein 24	1050	0.7
chr7_13598952_13599103	0.21	ETV1	ets variant 1	427039	0.01
chr12_62998810_62998961	0.21	ENSG00000199179	.	1419	0.27
chr4_114214241_114214392	0.21	ANK2	ankyrin 2, neuronal	178	0.97
chr1_28385802_28385953	0.21	EYA3	eyes absent homolog 3 (Drosophila)	1279	0.41
chr4_134068181_134068851	0.21	PCDH10	protocadherin 10	1954	0.52
chr13_68759883_68760034	0.21	ENSG00000243671	.	508255	0.0
chr10_51574745_51574998	0.21	NCOA4	nuclear receptor coactivator 4	1414	0.4
chr1_246149945_246150147	0.21	RP11-83A16.1		46807	0.18
chr2_188416196_188416496	0.21	AC007319.1		2530	0.3
chr8_9415740_9416105	0.21	RP11-375N15.2		1892	0.35
chr4_26909424_26909603	0.21	STIM2	stromal interaction molecule 2	46432	0.17
chr14_55041073_55041224	0.21	SAMD4A	sterile alpha motif domain containing 4A	6511	0.25
chr6_144355602_144355753	0.21	PLAGL1	pleiomorphic adenoma gene-like 1	26136	0.22
chr3_146755718_146755869	0.21	ENSG00000207156	.	41293	0.2
chr12_131401175_131401405	0.21	ENSG00000206850	.	9907	0.18
chr9_124031457_124031643	0.21	GSN	gelsolin	1170	0.41

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.4	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.4	GO:0060242	contact inhibition(GO:0060242)
0.1	0.4	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.6	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1	0.4	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.1	0.3	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	0.2	GO:0002125	maternal aggressive behavior(GO:0002125)
0.1	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.2	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0031223	auditory behavior(GO:0031223)
0.1	0.2	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0034501	protein localization to kinetochore(GO:0034501)
0.1	0.5	GO:0060216	definitive hemopoiesis(GO:0060216)
0.1	0.2	GO:0008218	bioluminescence(GO:0008218)
0.1	0.2	GO:0006552	leucine catabolic process(GO:0006552)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.2	GO:0010842	retina layer formation(GO:0010842)
0.1	0.2	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.1	0.2	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.2	GO:0001946	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.6	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.2	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.2	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.2	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.2	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.2	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0006531	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.5	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.2	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.2	GO:0021854	hypothalamus development(GO:0021854)
0.0	0.2	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.2	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0033630	positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0	0.0	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.2	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:1901889	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0016114	terpenoid biosynthetic process(GO:0016114)
0.0	0.1	GO:1902339	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.3	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0032430	obsolete regulation of natriuresis(GO:0003078) positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0036315	cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.2	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.1	GO:0051883	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.2	GO:0035115	embryonic forelimb morphogenesis(GO:0035115)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.2	GO:0048566	embryonic digestive tract development(GO:0048566)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.0	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:2001280	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.0	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.0	GO:0060430	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.3	GO:0051353	positive regulation of oxidoreductase activity(GO:0051353)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.2	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0006582	melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.0	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.2	GO:0030865	cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866)
0.0	0.1	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0003307	regulation of Wnt signaling pathway involved in heart development(GO:0003307) negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.2	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.0	GO:0071800	podosome assembly(GO:0071800)
0.0	0.0	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.0	GO:0051280	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	0.5	GO:0071438	invadopodium membrane(GO:0071438)
0.1	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.2	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.1	0.4	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.3	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.6	GO:0030665	clathrin-coated vesicle membrane(GO:0030665)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.0	GO:0030673	axolemma(GO:0030673)
0.0	0.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.0	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0043205	fibril(GO:0043205)
0.0	0.2	GO:0032300	mismatch repair complex(GO:0032300)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.4	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.2	GO:0030118	clathrin coat(GO:0030118)
0.0	0.2	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.3	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	0.3	GO:0004948	calcitonin receptor activity(GO:0004948)
0.1	0.5	GO:0005000	vasopressin receptor activity(GO:0005000)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.3	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	0.2	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.2	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.1	0.2	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.1	0.4	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.5	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.5	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.2	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.3	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.3	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.2	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0031782	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.0	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.0	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.1	NABA COLLAGENS	Genes encoding collagen proteins
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.3	PID BMP PATHWAY	BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.6	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.0	0.1	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.4	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.0	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.0	0.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME FRS2 MEDIATED CASCADE	Genes involved in FRS2-mediated cascade
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.0	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2