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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for NKX2-2

Z-value: 1.19

Motif logo

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.5 NK2 homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr20_21501454_21501605NKX2-268650.2250830.674.7e-02Click!
chr20_21528926_21529077NKX2-2343370.176605-0.551.3e-01Click!
chr20_21538382_21538533NKX2-2437930.157380-0.511.6e-01Click!
chr20_21538130_21538281NKX2-2435410.157894-0.452.3e-01Click!
chr20_21495239_21495416NKX2-26630.719751-0.245.4e-01Click!

Activity of the NKX2-2 motif across conditions

Conditions sorted by the z-value of the NKX2-2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_118745072_118745584 0.67 TAOK3
 TAO kinase 3
 51464
 0.15
chr5_39423780_39424080 0.66 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 1040
 0.66
chr1_224805949_224806359 0.48 CNIH3
 cornichon family AMPA receptor auxiliary protein 3
 2159
 0.29
chr7_77930640_77930829 0.47 RP5-1185I7.1
310997
 0.01
chr1_158969828_158970040 0.45 IFI16
 interferon, gamma-inducible protein 16
 176
 0.96
chr1_218672576_218672996 0.44 C1orf143
 chromosome 1 open reading frame 143
 10652
 0.26
chr6_56707059_56707245 0.43 DST
 dystonin
 791
 0.6
chr14_33045621_33045875 0.42 AKAP6
 A kinase (PRKA) anchor protein 6
 81470
 0.11
chr3_8809480_8810320 0.42 OXTR
 oxytocin receptor
 463
 0.76
chr1_156091066_156091427 0.40 LMNA
 lamin A/C
 4705
 0.12
chr7_94027358_94027511 0.39 COL1A2
 collagen, type I, alpha 2
 3561
 0.34
chr4_4494063_4494282 0.39 STX18-IT1
 STX18 intronic transcript 1 (non-protein coding)
 10745
 0.21
chr12_91573704_91574005 0.38 DCN
 decorin
 288
 0.94
chr1_164532131_164532342 0.38 PBX1
 pre-B-cell leukemia homeobox 1
 194
 0.97
chr13_77457508_77457742 0.37 KCTD12
 potassium channel tetramerization domain containing 12
 2900
 0.26
chr3_132316198_132316509 0.37 ACKR4
 atypical chemokine receptor 4
 272
 0.93
chr7_17030060_17030455 0.37 AGR3
 anterior gradient 3
 108646
 0.07
chr3_132315920_132316071 0.37 ACKR4
 atypical chemokine receptor 4
 86
 0.98
chr2_188312053_188312458 0.36 CALCRL
 calcitonin receptor-like
 724
 0.77
chr19_16403865_16404198 0.36 CTD-2562J15.6
355
 0.85
chr14_81866312_81866672 0.36 STON2
 stonin 2
 1565
 0.55
chr11_121968562_121968780 0.35 ENSG00000207971
 .
 1881
 0.27
chr5_72147028_72147179 0.35 TNPO1
 transportin 1
 3092
 0.26
chr5_98118231_98118548 0.35 RGMB
 repulsive guidance molecule family member b
 9050
 0.23
chr9_2838300_2838770 0.35 KIAA0020
 KIAA0020
 5706
 0.3
chr13_76020093_76020271 0.35 TBC1D4
 TBC1 domain family, member 4
 36068
 0.18
chr1_101359369_101359680 0.35 EXTL2
 exostosin-like glycosyltransferase 2
 696
 0.48
chr2_66664825_66665240 0.35 MEIS1
 Meis homeobox 1
 93
 0.96
chr13_95255061_95255225 0.34 GPR180
 G protein-coupled receptor 180
 986
 0.56
chr4_81191707_81191903 0.34 FGF5
 fibroblast growth factor 5
 4012
 0.29
chr4_119948824_119949052 0.34 SYNPO2
 synaptopodin 2
 4312
 0.32
chr11_101983358_101983513 0.34 YAP1
 Yes-associated protein 1
 190
 0.94
chr11_121969171_121969347 0.34 ENSG00000207971
 .
 1293
 0.36
chr4_151062450_151062706 0.33 DCLK2
 doublecortin-like kinase 2
 62398
 0.13
chr12_94761705_94761856 0.33 ENSG00000244391
 .
 6784
 0.22
chr20_17538596_17539086 0.33 BFSP1
 beaded filament structural protein 1, filensin
 642
 0.72
chr5_52136022_52136457 0.33 CTD-2288O8.1
52379
 0.13
chr2_175203994_175204145 0.33 AC018470.1
 Uncharacterized protein FLJ46347
 1918
 0.29
chr11_120195755_120196855 0.33 TMEM136
 transmembrane protein 136
 289
 0.9
chr11_74494468_74494674 0.32 ENSG00000264095
 .
 29942
 0.12
chr20_46121886_46122388 0.32 ENSG00000201742
 .
 308
 0.88
chr12_56916774_56917003 0.32 RBMS2
 RNA binding motif, single stranded interacting protein 2
 1105
 0.41
chr1_178269315_178269642 0.32 RASAL2
 RAS protein activator like 2
 41128
 0.2
chr1_119524620_119524878 0.32 TBX15
 T-box 15
 5679
 0.29
chr2_53803027_53803274 0.32 ENSG00000207456
 .
 5533
 0.28
chr1_89197420_89197765 0.31 PKN2
 protein kinase N2
 39546
 0.16
chr1_179111271_179111703 0.31 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
 692
 0.72
chr7_91923432_91923918 0.31 ANKIB1
 ankyrin repeat and IBR domain containing 1
 101
 0.97
chr9_110248378_110248529 0.31 KLF4
 Kruppel-like factor 4 (gut)
 2958
 0.29
chr3_185741982_185742377 0.31 ENSG00000266670
 .
 42096
 0.14
chr9_73539563_73539988 0.31 TRPM3
 transient receptor potential cation channel, subfamily M, member 3
 55801
 0.16
chr14_59949074_59949274 0.31 L3HYPDH
 L-3-hydroxyproline dehydratase (trans-)
 1229
 0.4
chr18_52919735_52919886 0.31 TCF4
 transcription factor 4
 23092
 0.25
chr18_34252707_34252889 0.31 ENSG00000252078
 .
 30151
 0.2
chr10_15546629_15546846 0.31 FAM171A1
 family with sequence similarity 171, member A1
 133676
 0.05
chr6_116833589_116833880 0.30 TRAPPC3L
 trafficking protein particle complex 3-like
 228
 0.83
chr8_105236286_105236489 0.30 RIMS2
 regulating synaptic membrane exocytosis 2
 507
 0.87
chr8_49447973_49448420 0.30 RP11-770E5.1
15931
 0.3
chr3_145968034_145968185 0.30 PLSCR4
 phospholipid scramblase 4
 545
 0.85
chr1_96354702_96354941 0.30 ENSG00000221798
 .
 2725
 0.41
chr13_80824494_80824698 0.29 SPRY2
 sprouty homolog 2 (Drosophila)
 89198
 0.1
chr6_132452290_132452699 0.29 ENSG00000265669
 .
 16091
 0.27
chr14_52821800_52821992 0.29 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 40783
 0.18
chr3_114369992_114370143 0.29 ZBTB20
 zinc finger and BTB domain containing 20
 26275
 0.25
chr6_161649839_161650239 0.29 AGPAT4
 1-acylglycerol-3-phosphate O-acyltransferase 4
 45012
 0.2
chr21_47404119_47404503 0.29 COL6A1
 collagen, type VI, alpha 1
 2660
 0.29
chr5_54456456_54456818 0.29 GPX8
 glutathione peroxidase 8 (putative)
 639
 0.58
chr12_88810686_88810837 0.28 ENSG00000199245
 .
 13458
 0.29
chr8_117466815_117467042 0.28 ENSG00000264815
 .
 167340
 0.04
chr1_200710499_200710966 0.28 CAMSAP2
 calmodulin regulated spectrin-associated protein family, member 2
 1825
 0.44
chr5_44389781_44390058 0.28 FGF10
 fibroblast growth factor 10
 111
 0.95
chr12_19284782_19284948 0.28 PLEKHA5
 pleckstrin homology domain containing, family A member 5
 2135
 0.35
chr11_46300696_46300847 0.28 CREB3L1
 cAMP responsive element binding protein 3-like 1
 1543
 0.37
chr17_21163251_21163402 0.28 C17orf103
 chromosome 17 open reading frame 103
 6604
 0.17
chrX_114849372_114849580 0.28 PLS3
 plastin 3
 4921
 0.25
chr2_198539715_198539970 0.28 RFTN2
 raftlin family member 2
 877
 0.6
chr10_76050173_76050375 0.28 ADK
 adenosine kinase
 113753
 0.06
chr8_38857241_38857490 0.28 ADAM9
 ADAM metallopeptidase domain 9
 2860
 0.19
chr8_116264905_116265143 0.27 TRPS1
 trichorhinophalangeal syndrome I
 239424
 0.02
chr2_153348906_153349057 0.27 FMNL2
 formin-like 2
 127111
 0.06
chr13_101202740_101202924 0.27 RP11-151A6.4
10772
 0.19
chr6_139692941_139693119 0.27 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 2320
 0.4
chr6_152701268_152701555 0.27 SYNE1-AS1
 SYNE1 antisense RNA 1
 270
 0.91
chr7_56160445_56160611 0.27 PHKG1
 phosphorylase kinase, gamma 1 (muscle)
 97
 0.94
chr3_146755933_146756085 0.27 ENSG00000207156
 .
 41509
 0.2
chr2_163099691_163099877 0.27 FAP
 fibroblast activation protein, alpha
 182
 0.96
chr3_159483781_159484285 0.27 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1141
 0.44
chr5_55420029_55420180 0.27 ENSG00000253032
 .
 1394
 0.4
chr1_198057970_198058261 0.27 NEK7
 NIMA-related kinase 7
 67978
 0.13
chr2_159610172_159610621 0.27 AC005042.4
18882
 0.21
chr4_170188672_170188986 0.26 SH3RF1
 SH3 domain containing ring finger 1
 2279
 0.41
chr4_87052385_87052536 0.26 RP11-778J15.1
11593
 0.23
chr3_145877576_145877727 0.26 PLOD2
 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 1128
 0.57
chr5_141920833_141921059 0.26 ENSG00000252831
 .
 7036
 0.25
chr4_114899439_114899761 0.26 ARSJ
 arylsulfatase family, member J
 552
 0.84
chr15_49758482_49758645 0.26 FGF7
 fibroblast growth factor 7
 43106
 0.17
chr2_220942198_220942388 0.26 ENSG00000221199
 .
 114306
 0.06
chr3_73159675_73159826 0.26 ENSG00000223247
 .
 393
 0.83
chr18_6030976_6031127 0.26 RP11-793A3.2
5961
 0.23
chr9_91929257_91929464 0.26 ENSG00000265112
 .
 2220
 0.26
chr18_7579845_7579996 0.26 PTPRM
 protein tyrosine phosphatase, receptor type, M
 12103
 0.29
chr2_171700467_171700658 0.26 GAD1
 glutamate decarboxylase 1 (brain, 67kDa)
 21965
 0.15
chr10_96163775_96164021 0.26 TBC1D12
 TBC1 domain family, member 12
 1637
 0.43
chr13_32786329_32786590 0.26 FRY
 furry homolog (Drosophila)
 52346
 0.14
chr14_90126270_90126545 0.26 ENSG00000252655
 .
 9160
 0.16
chr1_51438505_51438667 0.25 CDKN2C
 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
 2970
 0.28
chr2_169374767_169374972 0.25 CERS6
 ceramide synthase 6
 62110
 0.1
chr8_99740073_99740224 0.25 STK3
 serine/threonine kinase 3
 97751
 0.08
chr7_27236053_27236457 0.25 HOTTIP
 HOXA distal transcript antisense RNA
 1939
 0.13
chr9_21591325_21591685 0.25 MIR31HG
 MIR31 host gene (non-protein coding)
 31837
 0.16
chr1_214618329_214618746 0.25 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 19609
 0.26
chr15_36623332_36623712 0.25 C15orf41
 chromosome 15 open reading frame 41
 248290
 0.02
chr5_43308499_43308850 0.25 HMGCS1
 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
 4652
 0.23
chr12_116037117_116037430 0.25 ENSG00000240205
 .
 118257
 0.07
chr18_46020104_46020474 0.25 ENSG00000200872
 .
 18318
 0.21
chr7_18549761_18549974 0.25 HDAC9
 histone deacetylase 9
 931
 0.71
chr6_40687581_40687836 0.25 LRFN2
 leucine rich repeat and fibronectin type III domain containing 2
 132504
 0.05
chr11_48039463_48039614 0.25 AC103828.1
2131
 0.35
chr2_8143991_8144314 0.24 ENSG00000221255
 .
 427180
 0.01
chr17_31239173_31239327 0.24 TMEM98
 transmembrane protein 98
 15678
 0.17
chr10_95196659_95197038 0.24 MYOF
 myoferlin
 45103
 0.14
chr1_13910795_13911459 0.24 PDPN
 podoplanin
 362
 0.87
chr2_38373660_38374056 0.24 ENSG00000199603
 .
 699
 0.72
chr13_35963746_35963897 0.24 MAB21L1
 mab-21-like 1 (C. elegans)
 87011
 0.09
chr4_116464375_116464526 0.24 NDST4
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
 429418
 0.01
chr3_157154723_157155399 0.24 PTX3
 pentraxin 3, long
 483
 0.86
chr1_167693043_167693194 0.24 MPZL1
 myelin protein zero-like 1
 1729
 0.44
chr7_129850493_129850759 0.24 SSMEM1
 serine-rich single-pass membrane protein 1
 2926
 0.19
chr13_80066771_80066922 0.24 NDFIP2
 Nedd4 family interacting protein 2
 11258
 0.21
chr2_18595221_18595519 0.24 RDH14
 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
 146576
 0.04
chr15_71504267_71504460 0.24 RP11-673C5.2
22982
 0.23
chr4_175055764_175055915 0.24 FBXO8
 F-box protein 8
 148975
 0.04
chr3_25193430_25193657 0.24 RARB
 retinoic acid receptor, beta
 22280
 0.26
chr11_10229350_10229501 0.23 RP11-748C4.1
58686
 0.12
chr7_77388461_77388692 0.23 RSBN1L
 round spermatid basic protein 1-like
 336
 0.9
chr14_69709628_69709779 0.23 GALNT16
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
 16978
 0.2
chr1_101334241_101334590 0.23 EXTL2
 exostosin-like glycosyltransferase 2
 25805
 0.15
chr1_55701423_55701577 0.23 ENSG00000265822
 .
 10186
 0.23
chr18_12306690_12306841 0.23 TUBB6
 tubulin, beta 6 class V
 903
 0.54
chr5_95403437_95403808 0.23 ENSG00000207578
 .
 11220
 0.25
chr12_91092431_91092582 0.23 CCER1
 coiled-coil glutamate-rich protein 1
 256447
 0.02
chr5_39421239_39421390 0.23 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 3656
 0.34
chr7_120632569_120632731 0.23 CPED1
 cadherin-like and PC-esterase domain containing 1
 2974
 0.27
chr2_161274557_161274766 0.23 RBMS1
 RNA binding motif, single stranded interacting protein 1
 1972
 0.35
chr3_127633934_127634403 0.23 KBTBD12
 kelch repeat and BTB (POZ) domain containing 12
 93
 0.98
chrX_105951632_105951877 0.23 RNF128
 ring finger protein 128, E3 ubiquitin protein ligase
 14686
 0.24
chr5_142880921_142881072 0.23 ENSG00000253023
 .
 41156
 0.18
chr4_83996791_83996942 0.23 PLAC8
 placenta-specific 8
 34130
 0.14
chr16_27256849_27257000 0.23 NSMCE1
 non-SMC element 1 homolog (S. cerevisiae)
 12525
 0.16
chr4_99544258_99544409 0.23 TSPAN5
 tetraspanin 5
 34453
 0.18
chr10_13754786_13755077 0.23 RP11-295P9.6
2516
 0.19
chr5_95068939_95069254 0.23 CTD-2154I11.2
1097
 0.44
chr11_14375529_14375805 0.23 RRAS2
 related RAS viral (r-ras) oncogene homolog 2
 379
 0.91
chr1_178064247_178064419 0.23 RASAL2
 RAS protein activator like 2
 1057
 0.69
chrX_102940107_102940387 0.23 MORF4L2
 mortality factor 4 like 2
 902
 0.43
chr15_96878465_96878729 0.22 ENSG00000222651
 .
 2107
 0.24
chr8_19148668_19149118 0.22 SH2D4A
 SH2 domain containing 4A
 22235
 0.28
chr1_218550498_218550696 0.22 TGFB2
 transforming growth factor, beta 2
 31020
 0.18
chr1_203631994_203632193 0.22 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
 19844
 0.21
chr5_171269419_171269604 0.22 SMIM23
 small integral membrane protein 23
 56621
 0.13
chr6_136809157_136809308 0.22 MAP7
 microtubule-associated protein 7
 21219
 0.2
chr2_225276641_225276966 0.22 FAM124B
 family with sequence similarity 124B
 10001
 0.29
chr4_81177063_81177214 0.22 FGF5
 fibroblast growth factor 5
 10615
 0.24
chr3_130648403_130648554 0.22 RP11-39E3.3
342
 0.49
chr13_50650646_50650797 0.22 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 5586
 0.18
chr7_75984582_75984890 0.22 YWHAG
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
 3612
 0.2
chr10_54357540_54357691 0.22 RP11-556E13.1
36750
 0.23
chr11_33746911_33747062 0.22 CD59
 CD59 molecule, complement regulatory protein
 2488
 0.23
chr9_5518498_5518649 0.22 PDCD1LG2
 programmed cell death 1 ligand 2
 8003
 0.25
chr3_167780902_167781122 0.22 GOLIM4
 golgi integral membrane protein 4
 32120
 0.24
chr8_41862770_41862921 0.22 ENSG00000238966
 .
 38248
 0.15
chr19_7581346_7582140 0.22 ZNF358
 zinc finger protein 358
 739
 0.45
chr7_130602252_130602403 0.22 ENSG00000226380
 .
 40029
 0.17
chr12_63702500_63702651 0.22 AVPR1A
 arginine vasopressin receptor 1A
 157853
 0.04
chr5_82354364_82354515 0.22 ENSG00000238835
 .
 5717
 0.23
chr9_21968288_21968979 0.22 C9orf53
 chromosome 9 open reading frame 53
 1496
 0.32
chr3_99591263_99591414 0.21 FILIP1L
 filamin A interacting protein 1-like
 3610
 0.31
chr3_57094343_57094529 0.21 SPATA12
 spermatogenesis associated 12
 33
 0.98
chr7_143155212_143155383 0.21 TAS2R60
 taste receptor, type 2, member 60
 14751
 0.13
chr9_97811962_97812255 0.21 ENSG00000207563
 .
 35382
 0.12
chr8_128003605_128003873 0.21 ENSG00000212451
 .
 319972
 0.01
chr9_96932852_96933003 0.21 ENSG00000199165
 .
 5307
 0.17
chr10_128993776_128993991 0.21 FAM196A
 family with sequence similarity 196, member A
 539
 0.87
chr4_86397366_86397517 0.21 ARHGAP24
 Rho GTPase activating protein 24
 1050
 0.7
chr7_13598952_13599103 0.21 ETV1
 ets variant 1
 427039
 0.01
chr12_62998810_62998961 0.21 ENSG00000199179
 .
 1419
 0.27
chr4_114214241_114214392 0.21 ANK2
 ankyrin 2, neuronal
 178
 0.97
chr1_28385802_28385953 0.21 EYA3
 eyes absent homolog 3 (Drosophila)
 1279
 0.41
chr4_134068181_134068851 0.21 PCDH10
 protocadherin 10
 1954
 0.52
chr13_68759883_68760034 0.21 ENSG00000243671
 .
 508255
 0.0
chr10_51574745_51574998 0.21 NCOA4
 nuclear receptor coactivator 4
 1414
 0.4
chr1_246149945_246150147 0.21 RP11-83A16.1
46807
 0.18
chr2_188416196_188416496 0.21 AC007319.1
2530
 0.3
chr8_9415740_9416105 0.21 RP11-375N15.2
1892
 0.35
chr4_26909424_26909603 0.21 STIM2
 stromal interaction molecule 2
 46432
 0.17
chr14_55041073_55041224 0.21 SAMD4A
 sterile alpha motif domain containing 4A
 6511
 0.25
chr6_144355602_144355753 0.21 PLAGL1
 pleiomorphic adenoma gene-like 1
 26136
 0.22
chr3_146755718_146755869 0.21 ENSG00000207156
 .
 41293
 0.2
chr12_131401175_131401405 0.21 ENSG00000206850
 .
 9907
 0.18
chr9_124031457_124031643 0.21 GSN
 gelsolin
 1170
 0.41

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0060242 contact inhibition(GO:0060242)
0.1 0.4 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.6 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 0.4 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.3 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.2 GO:0002125 maternal aggressive behavior(GO:0002125)
0.1 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.2 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0031223 auditory behavior(GO:0031223)
0.1 0.2 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.2 GO:0008218 bioluminescence(GO:0008218)
0.1 0.2 GO:0006552 leucine catabolic process(GO:0006552)
0.1 0.2 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.2 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.2 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.2 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.6 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.2 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.2 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.2 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.5 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0042637 catagen(GO:0042637)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0010566 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.0 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0 0.2 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.2 GO:1901976 regulation of cell cycle checkpoint(GO:1901976)
0.0 0.2 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:2000644 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.1 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.0 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.2 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:1904358 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0035844 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:1901889 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.1 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.1 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.0 0.1 GO:1902339 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.3 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0032430 obsolete regulation of natriuresis(GO:0003078) positive regulation of phospholipase A2 activity(GO:0032430)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.1 GO:0036315 cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.2 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.1 GO:0051883 disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.2 GO:0048566 embryonic digestive tract development(GO:0048566)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.0 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.0 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.0 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.0 GO:0060430 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.0 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.3 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.1 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.1 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.0 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.0 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.2 GO:0030865 cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0003307 regulation of Wnt signaling pathway involved in heart development(GO:0003307) negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0071800 podosome assembly(GO:0071800)
0.0 0.0 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.0 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.0 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0051280 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.4 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.1 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.0 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.0 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0043205 fibril(GO:0043205)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.0 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.2 GO:0030118 clathrin coat(GO:0030118)
0.0 0.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001159 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.5 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0034739 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.2 GO:0051378 serotonin binding(GO:0051378)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0031782 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.0 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.0 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.0 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.0 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.0 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.0 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.3 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.1 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.0 REACTOME SIGNALING BY FGFR IN DISEASE Genes involved in Signaling by FGFR in disease
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.0 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2