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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for NKX2-3

Z-value: 1.34

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Transcription factors associated with NKX2-3

Gene Symbol	Gene ID	Gene Info
NKX2-3 Ensembl NCBI GeneCards UniProt	ENSG00000119919.9	NK2 homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr10_101295791_101295942	NKX2-3	3176	0.226777	0.74	2.4e-02	Click!
chr10_101292883_101293053	NKX2-3	278	0.888538	0.69	3.9e-02	Click!
chr10_101296030_101296181	NKX2-3	3415	0.219810	0.68	4.6e-02	Click!
chr10_101292603_101292869	NKX2-3	46	0.968012	0.63	6.7e-02	Click!
chr10_101296661_101296812	NKX2-3	4046	0.206474	-0.53	1.4e-01	Click!

Activity of the NKX2-3 motif across conditions

Conditions sorted by the z-value of the NKX2-3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_41592038_41592686	0.95	ELF1	E74-like factor 1 (ets domain transcription factor)	1088	0.53
chr12_47610316_47610761	0.62	PCED1B	PC-esterase domain containing 1B	157	0.96
chr7_45068352_45068655	0.58	CCM2	cerebral cavernous malformation 2	1232	0.4
chr10_121300707_121301020	0.56	RGS10	regulator of G-protein signaling 10	1357	0.51
chr3_16332139_16332290	0.56	OXNAD1	oxidoreductase NAD-binding domain containing 1	21466	0.15
chr20_35203812_35203967	0.55	TGIF2	TGFB-induced factor homeobox 2	814	0.36
chr5_156610422_156610951	0.53	ITK	IL2-inducible T-cell kinase	2849	0.18
chr2_68962051_68962936	0.53	ARHGAP25	Rho GTPase activating protein 25	479	0.86
chrY_1605889_1606059	0.51	NA	NA	> 10⁶	NA
chrX_1655895_1656063	0.50	P2RY8	purinergic receptor P2Y, G-protein coupled, 8	21	0.98
chr2_175461868_175462155	0.50	WIPF1	WAS/WASL interacting protein family, member 1	482	0.8
chr13_41555714_41555943	0.49	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr4_36244695_36244948	0.49	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	740	0.5
chr20_57721382_57721625	0.48	ZNF831	zinc finger protein 831	44572	0.15
chr4_143321559_143321710	0.47	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30778	0.27
chr6_17704634_17704930	0.46	RP11-500C11.3		1706	0.27
chr1_239883177_239883989	0.46	CHRM3	cholinergic receptor, muscarinic 3	740	0.59
chr6_126953293_126953444	0.46	ENSG00000201613	.	41829	0.21
chr8_66751055_66751459	0.45	PDE7A	phosphodiesterase 7A	274	0.95
chr13_46753488_46753737	0.45	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	2847	0.22
chr15_86233199_86233602	0.45	RP11-815J21.1		10940	0.11
chr8_87815635_87815786	0.45	CNGB3	cyclic nucleotide gated channel beta 3	59807	0.13
chr10_15296464_15296906	0.44	RP11-25G10.2		17194	0.24
chr4_122148073_122148224	0.44	TNIP3	TNFAIP3 interacting protein 3	473	0.85
chr12_15113209_15113383	0.44	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	904	0.55
chr2_235402254_235402496	0.44	ARL4C	ADP-ribosylation factor-like 4C	2869	0.42
chr1_186291189_186291340	0.43	ENSG00000202025	.	10204	0.17
chr3_142227777_142228000	0.43	RP11-383G6.3		36709	0.13
chrX_49120810_49120961	0.43	FOXP3	forkhead box P3	403	0.7
chr4_40199529_40199726	0.43	RHOH	ras homolog family member H	1100	0.55
chr10_114136486_114136682	0.43	ACSL5	acyl-CoA synthetase long-chain family member 5	627	0.73
chr7_43798895_43799046	0.42	BLVRA	biliverdin reductase A	684	0.72
chr10_14613286_14613530	0.42	FAM107B	family with sequence similarity 107, member B	621	0.79
chr6_149805654_149805958	0.42	ZC3H12D	zinc finger CCCH-type containing 12D	320	0.87
chr1_180469296_180469554	0.41	ACBD6	acyl-CoA binding domain containing 6	2664	0.28
chrX_123482778_123482929	0.41	SH2D1A	SH2 domain containing 1A	2414	0.44
chr4_36246504_36246655	0.41	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	448	0.68
chr2_204191257_204191408	0.41	ABI2	abl-interactor 2	1610	0.37
chr4_84035760_84036001	0.41	PLAC8	placenta-specific 8	9	0.98
chr1_167058816_167058967	0.40	GPA33	glycoprotein A33 (transmembrane)	977	0.5
chr17_29638237_29638396	0.40	EVI2B	ecotropic viral integration site 2B	2786	0.18
chr5_130883049_130883226	0.40	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14411	0.29
chr4_25333211_25333559	0.40	ZCCHC4	zinc finger, CCHC domain containing 4	1498	0.44
chr4_170948119_170948336	0.40	MFAP3L	microfibrillar-associated protein 3-like	134	0.97
chr15_64888931_64889431	0.40	ENSG00000207223	.	55906	0.09
chr1_67892671_67892822	0.39	SERBP1	SERPINE1 mRNA binding protein 1	3309	0.26
chrX_1324594_1325309	0.39	CRLF2	cytokine receptor-like factor 2	6576	0.2
chr17_37969894_37970059	0.39	IKZF3	IKAROS family zinc finger 3 (Aiolos)	35498	0.11
chrX_21391687_21391849	0.39	CNKSR2	connector enhancer of kinase suppressor of Ras 2	768	0.79
chr14_64967038_64967189	0.38	ZBTB1	zinc finger and BTB domain containing 1	3330	0.15
chr11_118215259_118215451	0.38	CD3G	CD3g molecule, gamma (CD3-TCR complex)	284	0.83
chr20_56963544_56964018	0.38	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	397	0.89
chr13_41556565_41556847	0.38	ELF1	E74-like factor 1 (ets domain transcription factor)	288	0.92
chr1_40527572_40527723	0.38	PPT1	palmitoyl-protein thioesterase 1	20346	0.16
chr8_11663359_11663510	0.38	FDFT1	farnesyl-diphosphate farnesyltransferase 1	2018	0.24
chr19_7413904_7414409	0.38	CTB-133G6.1		308	0.88
chr18_55298168_55298387	0.37	RP11-35G9.3		695	0.64
chr14_22320966_22321117	0.37	ENSG00000222776	.	72256	0.11
chr3_46448758_46448964	0.37	CCRL2	chemokine (C-C motif) receptor-like 2	188	0.64
chr17_43304013_43304236	0.37	CTD-2020K17.1		4535	0.11
chr8_8706094_8706267	0.37	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	44975	0.14
chr13_99958437_99958588	0.36	GPR183	G protein-coupled receptor 183	1147	0.52
chr2_10522774_10523051	0.36	HPCAL1	hippocalcin-like 1	37235	0.15
chr6_106550239_106550540	0.36	RP1-134E15.3		2374	0.32
chr8_18054756_18054907	0.36	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	12771	0.27
chr2_70121575_70121748	0.36	SNRNP27	small nuclear ribonucleoprotein 27kDa (U4/U6.U5)	570	0.65
chrX_129306486_129306674	0.35	RAB33A	RAB33A, member RAS oncogene family	957	0.57
chr9_117692323_117692779	0.35	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	146	0.98
chr1_26633523_26633687	0.35	UBXN11	UBX domain protein 11	125	0.94
chr2_235403089_235403368	0.35	ARL4C	ADP-ribosylation factor-like 4C	2016	0.5
chr6_154566682_154566833	0.35	IPCEF1	interaction protein for cytohesin exchange factors 1	1233	0.64
chr4_38511545_38511706	0.35	RP11-617D20.1		114571	0.06
chr5_137879838_137879998	0.35	ETF1	eukaryotic translation termination factor 1	929	0.48
chr3_111261912_111262220	0.35	CD96	CD96 molecule	1069	0.62
chr3_56788528_56788714	0.35	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	20974	0.24
chr17_47840030_47840441	0.34	FAM117A	family with sequence similarity 117, member A	1258	0.41
chr19_42057824_42058331	0.34	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	2191	0.27
chr1_93003304_93003455	0.34	GFI1	growth factor independent 1 transcription repressor	50946	0.15
chr1_244488212_244488377	0.33	C1orf100	chromosome 1 open reading frame 100	27643	0.22
chr6_106551609_106551898	0.33	RP1-134E15.3		3738	0.27
chr7_76829489_76829696	0.33	FGL2	fibrinogen-like 2	449	0.86
chr9_100692022_100692173	0.33	C9orf156	chromosome 9 open reading frame 156	7245	0.15
chr4_100738015_100738341	0.33	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	175	0.97
chr6_35266459_35266895	0.33	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1048	0.51
chr3_150920005_150920165	0.33	GPR171	G protein-coupled receptor 171	894	0.52
chr11_96073413_96073903	0.33	ENSG00000266192	.	944	0.55
chr10_77531854_77532472	0.33	C10orf11	chromosome 10 open reading frame 11	10356	0.22
chrY_23770406_23770557	0.32	RBMY1A1	RNA binding motif protein, Y-linked, family 1, member A1	71703	0.12
chr19_39896167_39896318	0.32	ZFP36	ZFP36 ring finger protein	1211	0.23
chr10_129846333_129846652	0.32	PTPRE	protein tyrosine phosphatase, receptor type, E	658	0.81
chr4_3344132_3344306	0.32	RGS12	regulator of G-protein signaling 12	64	0.98
chr6_90793348_90793499	0.32	ENSG00000222078	.	82198	0.09
chr7_105515013_105515164	0.32	ATXN7L1	ataxin 7-like 1	1835	0.48
chr12_1098384_1098535	0.32	RP11-359B12.2		748	0.35
chr2_214010651_214010802	0.32	IKZF2	IKAROS family zinc finger 2 (Helios)	2627	0.41
chr2_178127903_178128225	0.32	NFE2L2	nuclear factor, erythroid 2-like 2	118	0.91
chr7_21471147_21471369	0.32	SP4	Sp4 transcription factor	3597	0.23
chr4_48135850_48136064	0.32	TXK	TXK tyrosine kinase	316	0.88
chr10_22999624_22999775	0.32	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	3338	0.35
chr19_49839028_49839359	0.32	CD37	CD37 molecule	472	0.63
chr15_52428504_52428655	0.32	CTD-2184D3.7		2046	0.26
chr2_109238478_109238884	0.32	LIMS1	LIM and senescent cell antigen-like domains 1	959	0.64
chr5_150593261_150593549	0.32	GM2A	GM2 ganglioside activator	1694	0.36
chr12_131281744_131281942	0.31	ENSG00000238822	.	18055	0.19
chr7_30391674_30391825	0.31	ENSG00000207771	.	62339	0.1
chr19_39616079_39616250	0.31	PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	246	0.88
chr10_99610596_99610747	0.31	GOLGA7B	golgin A7 family, member B	675	0.69
chr1_84610455_84610717	0.31	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	632	0.82
chr1_160680712_160681035	0.31	CD48	CD48 molecule	720	0.63
chr10_30818195_30818576	0.31	ENSG00000239744	.	26448	0.21
chr3_141249287_141249763	0.31	RASA2-IT1	RASA2 intronic transcript 1 (non-protein coding)	5550	0.26
chr12_10020930_10021432	0.31	CLEC2B	C-type lectin domain family 2, member B	1554	0.25
chr2_24147099_24147310	0.31	ATAD2B	ATPase family, AAA domain containing 2B	2731	0.24
chr22_18531528_18531679	0.31	MICAL3	microtubule associated monooxygenase, calponin and LIM domain containing 3	24278	0.12
chr8_53615396_53615547	0.31	RB1CC1	RB1-inducible coiled-coil 1	11512	0.24
chr8_125576429_125576668	0.31	MTSS1	metastasis suppressor 1	1420	0.36
chr5_172478915_172479176	0.31	ENSG00000207210	.	513	0.74
chr4_2241544_2241736	0.31	POLN	polymerase (DNA directed) nu	2208	0.2
chr12_46660109_46660260	0.30	SLC38A1	solute carrier family 38, member 1	1300	0.59
chr20_34362397_34362548	0.30	PHF20	PHD finger protein 20	2524	0.2
chr13_48730530_48730681	0.30	MED4	mediator complex subunit 4	61338	0.11
chr4_14198140_14198291	0.30	ENSG00000202449	.	494119	0.0
chr4_30435059_30435210	0.30	PCDH7	protocadherin 7	286903	0.01
chr9_35649649_35650491	0.30	SIT1	signaling threshold regulating transmembrane adaptor 1	867	0.32
chr3_190233909_190234060	0.30	IL1RAP	interleukin 1 receptor accessory protein	2093	0.42
chr20_35575234_35575857	0.30	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr20_57739224_57739506	0.30	ZNF831	zinc finger protein 831	26710	0.21
chrX_78337620_78337771	0.30	GPR174	G protein-coupled receptor 174	88774	0.1
chr6_143228096_143228637	0.30	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	37972	0.2
chr6_96024670_96025209	0.30	MANEA-AS1	MANEA antisense RNA 1 (head to head)	387	0.57
chr11_115846152_115846499	0.30	ENSG00000238625	.	344736	0.01
chr15_34610151_34611295	0.30	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	257	0.87
chr5_154137578_154138162	0.30	LARP1	La ribonucleoprotein domain family, member 1	1136	0.49
chr2_128566778_128566929	0.29	WDR33	WD repeat domain 33	1674	0.29
chr19_10342329_10342480	0.29	DNMT1	DNA (cytosine-5-)-methyltransferase 1	442	0.39
chr13_31146685_31147402	0.29	HMGB1	high mobility group box 1	44691	0.16
chr21_36419709_36420003	0.29	RUNX1	runt-related transcription factor 1	1606	0.56
chr18_12775334_12775517	0.29	ENSG00000201466	.	14709	0.18
chr12_6736731_6736882	0.29	LPAR5	lysophosphatidic acid receptor 5	4009	0.1
chr8_96307989_96308140	0.29	C8orf37	chromosome 8 open reading frame 37	26635	0.24
chr14_99711224_99711514	0.29	AL109767.1		17916	0.2
chr20_25389039_25389190	0.29	GINS1	GINS complex subunit 1 (Psf1 homolog)	749	0.69
chr1_62905234_62905386	0.29	USP1	ubiquitin specific peptidase 1	2984	0.35
chr3_108546086_108546237	0.29	TRAT1	T cell receptor associated transmembrane adaptor 1	4542	0.3
chrY_1274396_1274718	0.29	NA	NA	> 10⁶	NA
chr10_74008803_74009027	0.29	DDIT4	DNA-damage-inducible transcript 4	24763	0.12
chr20_49134113_49134959	0.29	PTPN1	protein tyrosine phosphatase, non-receptor type 1	7616	0.17
chr2_102333802_102333953	0.29	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	18885	0.27
chr16_68451893_68452044	0.29	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	30427	0.12
chr10_64613060_64613211	0.28	EGR2	early growth response 2	34208	0.17
chr15_31115818_31116203	0.28	ENSG00000221379	.	22501	0.16
chr11_3010488_3011464	0.28	AC131971.1	HCG1782999; PRO0943; Uncharacterized protein	117	0.83
chr14_91869630_91869781	0.28	CCDC88C	coiled-coil domain containing 88C	13985	0.23
chr2_106776042_106776232	0.28	UXS1	UDP-glucuronate decarboxylase 1	903	0.66
chr1_171762483_171762634	0.28	METTL13	methyltransferase like 13	11716	0.15
chr1_116293768_116293919	0.28	CASQ2	calsequestrin 2 (cardiac muscle)	17492	0.24
chr8_125382183_125382334	0.28	TMEM65	transmembrane protein 65	2675	0.33
chr13_41588531_41588682	0.28	ELF1	E74-like factor 1 (ets domain transcription factor)	4844	0.22
chr14_61788916_61789580	0.28	PRKCH	protein kinase C, eta	134	0.7
chr1_150738258_150738451	0.28	CTSS	cathepsin S	79	0.96
chrX_24497884_24498038	0.28	PDK3	pyruvate dehydrogenase kinase, isozyme 3	14388	0.21
chr21_15917916_15918619	0.28	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr2_169458843_169458994	0.28	ENSG00000199348	.	4088	0.27
chr13_97879341_97880219	0.28	MBNL2	muscleblind-like splicing regulator 2	5171	0.33
chr7_30387809_30388007	0.28	ENSG00000207771	.	58498	0.11
chr19_23575597_23575748	0.28	ZNF91	zinc finger protein 91	2548	0.38
chrX_11162637_11162788	0.27	ENSG00000207151	.	28399	0.2
chr13_99856162_99856313	0.27	ENSG00000201793	.	1725	0.34
chr19_39896493_39896644	0.27	ZFP36	ZFP36 ring finger protein	885	0.33
chr14_100253258_100253409	0.27	EML1	echinoderm microtubule associated protein like 1	5688	0.27
chr1_167521603_167521971	0.27	CREG1	cellular repressor of E1A-stimulated genes 1	1217	0.5
chr3_66270798_66270949	0.27	SLC25A26	solute carrier family 25 (S-adenosylmethionine carrier), member 26	565	0.84
chr14_55800013_55800175	0.27	RP11-665C16.5		6125	0.25
chr13_107025788_107025939	0.27	EFNB2	ephrin-B2	161599	0.04
chrX_108780503_108781055	0.27	NXT2	nuclear transport factor 2-like export factor 2	432	0.88
chr4_100009284_100009464	0.27	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	528	0.5
chr12_123719357_123719698	0.27	C12orf65	chromosome 12 open reading frame 65	1225	0.32
chr11_5711907_5712253	0.27	TRIM22	tripartite motif containing 22	177	0.91
chr8_8747200_8747684	0.27	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	3713	0.24
chr3_57543780_57543931	0.27	PDE12	phosphodiesterase 12	1851	0.21
chrX_45667430_45667744	0.27	ENSG00000207725	.	61057	0.13
chrX_77151281_77151576	0.27	MAGT1	magnesium transporter 1	338	0.84
chr1_111415846_111416285	0.27	CD53	CD53 molecule	289	0.91
chr6_13273500_13273733	0.27	PHACTR1	phosphatase and actin regulator 1	627	0.46
chr14_22948364_22948515	0.27	ENSG00000251002	.	1839	0.18
chr2_9748111_9748300	0.27	ENSG00000207086	.	7191	0.19
chr2_198758371_198758522	0.27	PLCL1	phospholipase C-like 1	83464	0.1
chr4_48778362_48778513	0.27	FRYL	FRY-like	3828	0.27
chr1_90460194_90460489	0.26	ZNF326	zinc finger protein 326	333	0.91
chr13_99891313_99891464	0.26	GPR18	G protein-coupled receptor 18	19240	0.17
chr9_125666381_125666562	0.26	RC3H2	ring finger and CCCH-type domains 2	1023	0.39
chr11_128388975_128389288	0.26	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	2965	0.31
chr1_151028526_151028866	0.26	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	1538	0.19
chr19_49838375_49839003	0.26	CD37	CD37 molecule	5	0.95
chr5_169078279_169078459	0.26	DOCK2	dedicator of cytokinesis 2	14118	0.25
chr6_135343190_135343341	0.26	HBS1L	HBS1-like (S. cerevisiae)	5029	0.24
chr17_2169281_2169432	0.26	SMG6	SMG6 nonsense mediated mRNA decay factor	69	0.96
chr14_64968852_64969034	0.26	ZBTB1	zinc finger and BTB domain containing 1	1500	0.24
chr7_8011713_8012079	0.26	AC006042.7		2362	0.25
chr20_34356216_34356461	0.26	ENSG00000222152	.	1451	0.3

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.6	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2	0.5	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.5	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.4	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.5	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.3	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.6	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.3	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.3	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.3	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.1	0.3	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1	0.2	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.1	0.2	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.1	0.3	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.1	0.2	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.1	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.1	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.2	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.1	0.2	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.1	0.3	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.1	0.2	GO:0000212	meiotic spindle organization(GO:0000212)
0.1	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.2	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.1	0.5	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.1	0.2	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	0.5	GO:0032456	endocytic recycling(GO:0032456)
0.1	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.2	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.1	0.1	GO:0042686	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.1	0.2	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0071028	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.3	GO:0042723	thiamine-containing compound metabolic process(GO:0042723)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.2	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0035624	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.6	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0002220	innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0	0.2	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.2	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.4	GO:0031529	ruffle organization(GO:0031529)
0.0	0.2	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.3	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.2	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.2	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:1902019	regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.3	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.2	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.2	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.2	GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.5	GO:0002920	regulation of humoral immune response(GO:0002920)
0.0	0.0	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.1	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.5	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.2	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.2	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.2	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.4	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.4	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0046500	S-adenosylmethionine metabolic process(GO:0046500)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.0	GO:1903306	negative regulation of regulated secretory pathway(GO:1903306)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.2	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.5	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.2	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.2	GO:0048200	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0006530	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0014009	glial cell proliferation(GO:0014009)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.3	GO:0048199	vesicle targeting, to, from or within Golgi(GO:0048199)
0.0	0.4	GO:1900181	negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590)
0.0	0.2	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.2	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.6	GO:0006997	nucleus organization(GO:0006997)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.4	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.1	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.0	GO:0002577	regulation of antigen processing and presentation(GO:0002577) positive regulation of antigen processing and presentation(GO:0002579) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.1	GO:0010916	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.1	GO:0021610	cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612) anatomical structure arrangement(GO:0048532)
0.0	0.2	GO:0051900	regulation of mitochondrial depolarization(GO:0051900)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	1.2	GO:0006405	RNA export from nucleus(GO:0006405)
0.0	0.1	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.0	GO:1903959	regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) regulation of anion transmembrane transport(GO:1903959) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.3	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0000959	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.9	GO:0051028	mRNA transport(GO:0051028)
0.0	0.2	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0042921	corticosteroid receptor signaling pathway(GO:0031958) glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.1	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.0	0.1	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.1	GO:0010826	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.4	GO:0042267	natural killer cell mediated immunity(GO:0002228) natural killer cell mediated cytotoxicity(GO:0042267)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0006273	lagging strand elongation(GO:0006273)
0.0	0.4	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.4	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.1	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.2	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0021903	rostrocaudal neural tube patterning(GO:0021903)
0.0	0.1	GO:0000090	mitotic anaphase(GO:0000090)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0042094	interleukin-2 biosynthetic process(GO:0042094)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.8	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0033363	secretory granule organization(GO:0033363)
0.0	0.3	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.2	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.3	GO:0034620	endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0	0.0	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.0	GO:0051322	anaphase(GO:0051322)
0.0	0.1	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0	0.2	GO:0016577	histone demethylation(GO:0016577)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:0031341	regulation of cell killing(GO:0031341)
0.0	0.1	GO:0006301	postreplication repair(GO:0006301)
0.0	0.3	GO:0007098	centrosome cycle(GO:0007098)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.0	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.3	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.0	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.0	GO:0032071	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.1	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0002097	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0014044	Schwann cell development(GO:0014044)
0.0	0.1	GO:0009129	pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.2	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.0	GO:1903312	negative regulation of protein export from nucleus(GO:0046826) negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0015780	nucleotide-sugar transport(GO:0015780)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.4	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0006903	vesicle targeting(GO:0006903)
0.0	0.0	GO:0050798	activated T cell proliferation(GO:0050798)
0.0	0.0	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881)
0.0	0.7	GO:0006968	cellular defense response(GO:0006968)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.0	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.0	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:1904238	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.0	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.0	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.2	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.0	GO:0042640	anagen(GO:0042640)
0.0	0.3	GO:0000724	double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0	0.3	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.0	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0070193	synaptonemal complex organization(GO:0070193)
0.0	0.0	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.0	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.0	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.1	GO:0006111	regulation of gluconeogenesis(GO:0006111)
0.0	0.1	GO:0009812	flavonoid metabolic process(GO:0009812)
0.0	0.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.0	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.0	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.0	GO:0072081	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:1903020	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.9	GO:0006334	nucleosome assembly(GO:0006334) chromatin assembly(GO:0031497)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.0	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.1	GO:0006984	ER-nucleus signaling pathway(GO:0006984)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.1	GO:0006400	tRNA modification(GO:0006400)
0.0	0.3	GO:0017156	calcium ion regulated exocytosis(GO:0017156)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.0	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:0007341	penetration of zona pellucida(GO:0007341)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.4	GO:0006333	chromatin assembly or disassembly(GO:0006333)
0.0	0.0	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.7	GO:0018196	peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.1	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.0	GO:0032691	negative regulation of interleukin-1 beta production(GO:0032691) negative regulation of interleukin-1 production(GO:0032692)
0.0	0.4	GO:0006094	gluconeogenesis(GO:0006094)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.1	GO:0008105	asymmetric protein localization(GO:0008105)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.2	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	0.2	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	0.3	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	0.2	GO:0001652	granular component(GO:0001652)
0.1	0.2	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.6	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.3	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.5	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.7	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.3	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.4	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.2	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.3	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.3	GO:0034464	BBSome(GO:0034464)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0000407	pre-autophagosomal structure(GO:0000407) ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.2	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.9	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.8	GO:0016592	mediator complex(GO:0016592)
0.0	0.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.8	GO:0030175	filopodium(GO:0030175)
0.0	0.5	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.3	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.3	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.4	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.6	GO:0042645	mitochondrial nucleoid(GO:0042645)
0.0	1.3	GO:0005643	nuclear pore(GO:0005643)
0.0	0.1	GO:0005682	U5 snRNP(GO:0005682)
0.0	2.1	GO:0016607	nuclear speck(GO:0016607)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.8	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.0	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.0	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.2	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.0	GO:0031501	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0030681	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:1902555	endoribonuclease complex(GO:1902555)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.0	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.7	GO:0000786	nucleosome(GO:0000786)
0.0	0.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.0	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.4	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.4	GO:0000794	condensed nuclear chromosome(GO:0000794)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.4	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.2	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.1	1.8	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.1	0.4	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.4	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	0.5	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1	0.4	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	0.2	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.1	0.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	0.6	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	0.2	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.2	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.1	0.3	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.3	GO:0016778	diphosphotransferase activity(GO:0016778)
0.1	0.5	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.6	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.4	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.3	GO:0050733	RS domain binding(GO:0050733)
0.0	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.2	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.4	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.2	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.5	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.2	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.2	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.3	GO:0005123	death receptor binding(GO:0005123)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.3	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.0	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.2	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.4	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	1.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.5	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	1.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.3	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.3	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.4	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	1.4	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.3	GO:0015923	mannosidase activity(GO:0015923)
0.0	0.4	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.6	GO:0003724	RNA helicase activity(GO:0003724)
0.0	0.2	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.5	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.0	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.2	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.1	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.2	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.4	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.1	GO:0030021	extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0	0.3	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0004659	prenyltransferase activity(GO:0004659)
0.0	0.0	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.2	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.2	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.2	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.0	GO:0034452	dynactin binding(GO:0034452)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.2	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.0	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.4	GO:0019003	GDP binding(GO:0019003)
0.0	0.7	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.4	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.2	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.2	GO:0030331	estrogen receptor binding(GO:0030331)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.2	GO:0008417	fucosyltransferase activity(GO:0008417)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0005221	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0	0.7	GO:0008026	ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0070513	death domain binding(GO:0070513)
0.0	0.0	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.2	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.2	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.0	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.2	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.4	GO:0003954	NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.0	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0016878	acid-thiol ligase activity(GO:0016878)
0.0	0.2	GO:0043022	ribosome binding(GO:0043022)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0033549	MAP kinase phosphatase activity(GO:0033549)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.0	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.1	GO:0008175	tRNA methyltransferase activity(GO:0008175)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.0	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.2	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.2	GO:0000049	tRNA binding(GO:0000049)
0.0	0.1	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.1	GO:1901682	sulfur compound transmembrane transporter activity(GO:1901682)
0.0	0.2	GO:0005504	fatty acid binding(GO:0005504)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.8	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	1.6	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.9	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.4	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.5	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.5	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.5	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.8	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.6	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.4	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.1	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.5	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.0	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.1	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.2	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.4	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.0	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.2	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.3	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.5	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	0.2	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.2	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	0.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.7	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.0	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.5	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.5	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.6	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.5	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.7	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.2	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.9	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.3	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.2	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.3	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	1.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.4	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	1.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	1.4	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	0.0	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0	0.2	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	1.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.0	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.5	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.0	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.5	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.1	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0	0.2	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.2	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.0	0.2	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.0	REACTOME INFLUENZA LIFE CYCLE	Genes involved in Influenza Life Cycle
0.0	0.2	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.1	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.6	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.0	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.0	REACTOME ORC1 REMOVAL FROM CHROMATIN	Genes involved in Orc1 removal from chromatin
0.0	0.6	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.0	0.1	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.3	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1

Results for NKX2-3

Z-value: 1.34

Motif logo

Transcription factors associated with NKX2-3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the NKX2-3 motif across conditions

Conditions sorted by the z-value of the NKX2-3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: