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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX2-6

Z-value: 0.51

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Transcription factors associated with NKX2-6

Gene Symbol	Gene ID	Gene Info
NKX2-6 Ensembl NCBI GeneCards UniProt	ENSG00000180053.6	NKX2-6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX2-6	chr8_23562532_23562683	1315	0.359028	0.74	2.2e-02	Click!
NKX2-6	chr8_23563794_23563945	53	0.935410	-0.46	2.2e-01	Click!
NKX2-6	chr8_23562338_23562489	1509	0.323056	0.24	5.4e-01	Click!
NKX2-6	chr8_23563950_23564574	151	0.764890	-0.03	9.4e-01	Click!

Activity of the NKX2-6 motif across conditions

Conditions sorted by the z-value of the NKX2-6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_132315920_132316071	0.31	ACKR4	atypical chemokine receptor 4	86	0.98
chr2_175197281_175197503	0.30	SP9	Sp9 transcription factor	2282	0.26
chr8_106743100_106743756	0.28	RP11-642D21.2		45435	0.16
chr22_36310772_36312004	0.27	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	23557	0.25
chr12_20523872_20524102	0.26	RP11-284H19.1		791	0.64
chr3_127540841_127541975	0.26	MGLL	monoglyceride lipase	214	0.96
chr7_119912758_119913222	0.25	KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	732	0.81
chr11_121968562_121968780	0.23	ENSG00000207971	.	1881	0.27
chr6_28175291_28175856	0.22	ZSCAN9	zinc finger and SCAN domain containing 9	17091	0.12
chr2_159610172_159610621	0.22	AC005042.4		18882	0.21
chr7_116142833_116142984	0.22	CAV2	caveolin 2	3074	0.2
chr6_72129322_72130506	0.21	ENSG00000207827	.	16590	0.22
chr17_57229359_57229924	0.21	SKA2	spindle and kinetochore associated complex subunit 2	479	0.57
chr6_56614643_56614951	0.21	DST	dystonin	35880	0.21
chr11_69458516_69459047	0.21	CCND1	cyclin D1	2807	0.29
chr7_80547175_80548098	0.20	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	863	0.76
chr6_86114788_86115158	0.20	NT5E	5'-nucleotidase, ecto (CD73)	44836	0.19
chr7_15725092_15725754	0.20	MEOX2	mesenchyme homeobox 2	1014	0.63
chr4_169799680_169799831	0.20	ENSG00000201176	.	6751	0.22
chr8_494094_494251	0.19	TDRP	testis development related protein	665	0.79
chr18_61554936_61555215	0.19	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	82	0.97
chr12_13350846_13351208	0.19	EMP1	epithelial membrane protein 1	1307	0.55
chr1_158969828_158970040	0.19	IFI16	interferon, gamma-inducible protein 16	176	0.96
chr20_19916034_19916185	0.19	RIN2	Ras and Rab interactor 2	45899	0.15
chr21_31311288_31312406	0.19	GRIK1	glutamate receptor, ionotropic, kainate 1	3	0.99
chr20_6749993_6750220	0.19	BMP2	bone morphogenetic protein 2	1795	0.51
chr10_4719640_4719886	0.18	AKR1E2	aldo-keto reductase family 1, member E2	109058	0.07
chr4_74975461_74975696	0.18	CXCL2	chemokine (C-X-C motif) ligand 2	10568	0.16
chr20_13976647_13977145	0.18	SEL1L2	sel-1 suppressor of lin-12-like 2 (C. elegans)	193	0.78
chr7_13959407_13959706	0.18	ETV1	ets variant 1	66510	0.14
chr9_86916681_86916945	0.18	RP11-380F14.2		23679	0.22
chr8_8154312_8154463	0.17	ALG1L13P	asparagine-linked glycosylation 1-like 13, pseudogene	55454	0.11
chr4_180980346_180980880	0.17	NA	NA	> 10⁶	NA
chr4_23890131_23890306	0.17	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	1440	0.57
chr2_226896266_226896823	0.17	NYAP2	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	622947	0.0
chr1_13910795_13911459	0.17	PDPN	podoplanin	362	0.87
chr1_167721376_167721626	0.17	MPZL1	myelin protein zero-like 1	13306	0.23
chr8_6691754_6692464	0.17	DEFB1	defensin, beta 1	43435	0.14
chr11_16947220_16947414	0.17	PLEKHA7	pleckstrin homology domain containing, family A member 7	44412	0.12
chr2_216297601_216297993	0.16	FN1	fibronectin 1	2993	0.27
chrX_3264180_3264467	0.16	MXRA5	matrix-remodelling associated 5	359	0.92
chr8_37350646_37351319	0.16	RP11-150O12.6		23557	0.24
chr13_52165265_52165666	0.16	ENSG00000242893	.	2886	0.18
chr10_16909529_16909705	0.16	RSU1	Ras suppressor protein 1	50090	0.17
chr3_49447935_49448923	0.16	RHOA	ras homolog family member A	932	0.32
chr8_38857241_38857490	0.16	ADAM9	ADAM metallopeptidase domain 9	2860	0.19
chr1_162534114_162534517	0.16	UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1	1512	0.34
chr8_87934784_87934935	0.16	CNBD1	cyclic nucleotide binding domain containing 1	56186	0.17
chr15_83951840_83952048	0.16	BNC1	basonuclin 1	127	0.97
chr12_124990844_124991534	0.16	NCOR2	nuclear receptor corepressor 2	11391	0.3
chr14_71838527_71838748	0.16	ENSG00000207444	.	26417	0.18
chr13_110957949_110958238	0.16	COL4A2	collagen, type IV, alpha 2	66	0.97
chr4_80572253_80572434	0.15	OR7E94P	olfactory receptor, family 7, subfamily E, member 94 pseudogene	63059	0.15
chr1_179110770_179111258	0.15	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	1165	0.52
chr10_95227944_95228273	0.15	MYOF	myoferlin	13843	0.19
chr8_91782901_91783052	0.15	NECAB1	N-terminal EF-hand calcium binding protein 1	20802	0.19
chr8_30668680_30668831	0.15	PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	963	0.63
chr4_129998585_129998736	0.15	C4orf33	chromosome 4 open reading frame 33	15812	0.24
chr8_104090727_104091208	0.15	ENSG00000265667	.	13982	0.15
chr7_91923432_91923918	0.15	ANKIB1	ankyrin repeat and IBR domain containing 1	101	0.97
chr1_214723042_214723197	0.15	PTPN14	protein tyrosine phosphatase, non-receptor type 14	1447	0.54
chr5_158611818_158612659	0.15	RNF145	ring finger protein 145	22404	0.16
chr7_78398482_78399243	0.15	MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	1534	0.56
chr5_107041117_107041487	0.15	ENSG00000239708	.	29465	0.21
chrX_19716439_19716715	0.15	SH3KBP1	SH3-domain kinase binding protein 1	27461	0.25
chr9_97811337_97811671	0.15	ENSG00000207563	.	35986	0.11
chr5_158126537_158126688	0.15	CTD-2363C16.1		283402	0.01
chr3_29327656_29328192	0.15	RBMS3-AS3	RBMS3 antisense RNA 3	4293	0.26
chr13_24121051_24121276	0.15	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	23346	0.25
chr3_99766860_99767059	0.15	FILIP1L	filamin A interacting protein 1-like	66398	0.1
chr4_157891142_157892336	0.15	PDGFC	platelet derived growth factor C	316	0.91
chr6_56406612_56407191	0.14	DST	dystonin	68113	0.13
chr7_12663902_12664053	0.14	SCIN	scinderin	19839	0.21
chr4_85886471_85886934	0.14	WDFY3	WD repeat and FYVE domain containing 3	801	0.75
chr10_102921756_102921944	0.14	RP11-31L23.3		22382	0.12
chr7_27274920_27275071	0.14	EVX1	even-skipped homeobox 1	7169	0.1
chr10_51574745_51574998	0.14	NCOA4	nuclear receptor coactivator 4	1414	0.4
chr1_16466376_16466578	0.14	RP11-276H7.2		15229	0.11
chr15_59598169_59598320	0.14	RP11-429D19.1		34883	0.11
chrX_10602528_10602751	0.14	MID1	midline 1 (Opitz/BBB syndrome)	13965	0.27
chr22_43017042_43017193	0.14	ENSG00000270022	.	5867	0.12
chr12_3034547_3034860	0.14	ENSG00000238689	.	3428	0.16
chr7_82071524_82071810	0.14	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	1364	0.61
chr14_59949074_59949274	0.14	L3HYPDH	L-3-hydroxyproline dehydratase (trans-)	1229	0.4
chr11_121972599_121972750	0.14	RP11-166D19.1		200	0.92
chr5_171269419_171269604	0.14	SMIM23	small integral membrane protein 23	56621	0.13
chr1_206687074_206687508	0.14	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	6412	0.15
chr2_192710069_192710427	0.14	AC098617.1		1017	0.51
chr19_6103641_6103897	0.14	CTB-66B24.1		5564	0.15
chr6_18053801_18053981	0.14	KIF13A	kinesin family member 13A	66037	0.11
chr8_37555995_37556200	0.14	ZNF703	zinc finger protein 703	2828	0.18
chr12_59309288_59309823	0.14	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3	1191	0.55
chr1_200710499_200710966	0.14	CAMSAP2	calmodulin regulated spectrin-associated protein family, member 2	1825	0.44
chr15_68573802_68573977	0.14	FEM1B	fem-1 homolog b (C. elegans)	1592	0.39
chr15_72529055_72529849	0.14	PKM	pyruvate kinase, muscle	5288	0.17
chr3_49169788_49170138	0.14	LAMB2	laminin, beta 2 (laminin S)	490	0.65
chr20_47299051_47299422	0.13	ENSG00000251876	.	56749	0.16
chr7_102990167_102990648	0.13	PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	2297	0.25
chr3_61560941_61561100	0.13	PTPRG	protein tyrosine phosphatase, receptor type, G	13435	0.31
chr1_101359369_101359680	0.13	EXTL2	exostosin-like glycosyltransferase 2	696	0.48
chr1_70688549_70688700	0.13	SRSF11	serine/arginine-rich splicing factor 11	1479	0.33
chr5_16934966_16935117	0.13	MYO10	myosin X	1006	0.59
chr9_20511940_20512213	0.13	ENSG00000264941	.	9736	0.23
chr14_65928823_65928974	0.13	ENSG00000207781	.	8922	0.25
chr12_56513564_56513771	0.13	RP11-603J24.6		56	0.9
chr5_141278602_141278753	0.13	PCDH1	protocadherin 1	19866	0.14
chr6_155005040_155005564	0.13	SCAF8	SR-related CTD-associated factor 8	49157	0.17
chr1_109824775_109824999	0.13	PSRC1	proline/serine-rich coiled-coil 1	586	0.7
chr3_11551023_11551396	0.13	VGLL4	vestigial like 4 (Drosophila)	59189	0.14
chr12_105651079_105651410	0.13	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	21228	0.19
chr6_119667569_119668515	0.13	MAN1A1	mannosidase, alpha, class 1A, member 1	2859	0.34
chr4_114214241_114214392	0.13	ANK2	ankyrin 2, neuronal	178	0.97
chr7_27205863_27206297	0.13	HOXA9	homeobox A9	931	0.25
chr2_127822596_127822803	0.13	BIN1	bridging integrator 1	41878	0.16
chr7_17030060_17030455	0.13	AGR3	anterior gradient 3	108646	0.07
chr9_21555046_21555197	0.13	MIR31HG	MIR31 host gene (non-protein coding)	4547	0.21
chr19_16403865_16404198	0.13	CTD-2562J15.6		355	0.85
chr2_17722476_17722627	0.13	VSNL1	visinin-like 1	124	0.98
chr1_150481112_150481644	0.12	ECM1	extracellular matrix protein 1	795	0.48
chr12_56916774_56917003	0.12	RBMS2	RNA binding motif, single stranded interacting protein 2	1105	0.41
chr2_31360151_31360442	0.12	GALNT14	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	591	0.81
chr9_97811962_97812255	0.12	ENSG00000207563	.	35382	0.12
chr5_151065179_151065606	0.12	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	601	0.67
chr12_6494464_6494615	0.12	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	254	0.87
chr22_43386709_43386953	0.12	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	11615	0.21
chr11_114861879_114862030	0.12	ENSG00000252870	.	137139	0.05
chr9_97768076_97768588	0.12	C9orf3	chromosome 9 open reading frame 3	1054	0.55
chr5_82767889_82768074	0.12	VCAN	versican	237	0.96
chr5_54916685_54916836	0.12	SLC38A9	solute carrier family 38, member 9	71688	0.1
chr10_35102956_35103650	0.12	PARD3	par-3 family cell polarity regulator	946	0.5
chr13_113689501_113689756	0.12	MCF2L	MCF.2 cell line derived transforming sequence-like	9348	0.15
chr2_1734119_1734469	0.12	PXDN	peroxidasin homolog (Drosophila)	13920	0.26
chr17_4762663_4762814	0.12	ENSG00000263599	.	16183	0.08
chr7_101596567_101596967	0.12	CTB-181H17.1		6629	0.27
chr1_170630999_170631537	0.12	PRRX1	paired related homeobox 1	1007	0.68
chr10_62541267_62541606	0.12	CDK1	cyclin-dependent kinase 1	1525	0.51
chr11_61456591_61456863	0.12	DAGLA	diacylglycerol lipase, alpha	8822	0.18
chr6_16339042_16339210	0.12	ENSG00000265642	.	89628	0.08
chr12_89846997_89847148	0.12	POC1B	POC1 centriolar protein B	43962	0.13
chr2_46546253_46546404	0.12	EPAS1	endothelial PAS domain protein 1	21787	0.24
chr3_11755297_11755448	0.12	VGLL4	vestigial like 4 (Drosophila)	3361	0.34
chr14_102446484_102446635	0.12	DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	15694	0.19
chr13_43842946_43843190	0.12	ENOX1	ecto-NOX disulfide-thiol exchanger 1	92145	0.1
chr7_107221551_107221702	0.12	BCAP29	B-cell receptor-associated protein 29	422	0.69
chr7_100464814_100466140	0.12	TRIP6	thyroid hormone receptor interactor 6	717	0.47
chr1_98514169_98514606	0.12	ENSG00000225206	.	2660	0.42
chr6_18389672_18389881	0.12	RNF144B	ring finger protein 144B	2195	0.34
chr14_92997841_92998087	0.12	RIN3	Ras and Rab interactor 3	17816	0.26
chr5_149462966_149463221	0.12	CSF1R	colony stimulating factor 1 receptor	2897	0.21
chr5_78204137_78204521	0.12	ARSB	arylsulfatase B	77279	0.11
chr2_47527627_47527778	0.12	EPCAM	epithelial cell adhesion molecule	44595	0.13
chr4_141018823_141018974	0.12	RP11-392B6.1		30271	0.2
chr1_212812342_212812619	0.12	RP11-338C15.5		12367	0.14
chr14_68613241_68613392	0.12	ENSG00000244677	.	3309	0.29
chr3_4624343_4624494	0.12	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	66242	0.12
chr15_92438505_92438656	0.12	SLCO3A1	solute carrier organic anion transporter family, member 3A1	41229	0.19
chrX_31284819_31285011	0.11	DMD	dystrophin	59	0.99
chr2_159992813_159993143	0.11	ENSG00000202029	.	109324	0.06
chr1_178269315_178269642	0.11	RASAL2	RAS protein activator like 2	41128	0.2
chr4_140793537_140793902	0.11	MAML3	mastermind-like 3 (Drosophila)	17487	0.25
chr8_38585652_38586394	0.11	TACC1	transforming, acidic coiled-coil containing protein 1	82	0.97
chr5_61681454_61681605	0.11	DIMT1	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)	18196	0.17
chr1_57043984_57044408	0.11	PPAP2B	phosphatidic acid phosphatase type 2B	1045	0.66
chr12_110720958_110721647	0.11	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	1816	0.41
chr2_153382153_153382407	0.11	FMNL2	formin-like 2	93812	0.09
chr6_108486676_108487297	0.11	OSTM1	osteopetrosis associated transmembrane protein 1	58	0.78
chr7_27236053_27236457	0.11	HOTTIP	HOXA distal transcript antisense RNA	1939	0.13
chr3_177978802_177979100	0.11	KCNMB2	potassium large conductance calcium-activated channel, subfamily M, beta member 2	11769	0.3
chr3_99360396_99360669	0.11	COL8A1	collagen, type VIII, alpha 1	3078	0.35
chr20_6764834_6765429	0.11	BMP2	bone morphogenetic protein 2	16820	0.28
chr19_10736478_10736985	0.11	SLC44A2	solute carrier family 44 (choline transporter), member 2	530	0.65
chr4_113803321_113803472	0.11	RP11-119H12.6		90	0.98
chr16_54464970_54465224	0.11	ENSG00000264079	.	118211	0.06
chr4_20195598_20195749	0.11	SLIT2	slit homolog 2 (Drosophila)	59210	0.17
chr2_97593411_97593614	0.11	ENSG00000252845	.	29040	0.12
chr9_117439582_117439814	0.11	ENSG00000272241	.	60871	0.1
chr10_17241830_17242242	0.11	TRDMT1	tRNA aspartic acid methyltransferase 1	1543	0.37
chr5_139968434_139968585	0.11	ENSG00000200235	.	9257	0.08
chr12_118745072_118745584	0.11	TAOK3	TAO kinase 3	51464	0.15
chr22_29106631_29107007	0.11	CHEK2	checkpoint kinase 2	1100	0.47
chr3_188149558_188149830	0.11	LPP-AS1	LPP antisense RNA 1	136760	0.05
chr12_54778714_54778870	0.11	ZNF385A	zinc finger protein 385A	256	0.84
chr12_13408941_13409103	0.11	EMP1	epithelial membrane protein 1	44577	0.17
chrX_107683395_107684019	0.11	COL4A5	collagen, type IV, alpha 5	595	0.63
chr1_245331414_245331723	0.11	KIF26B	kinesin family member 26B	13281	0.2
chr16_54321004_54321411	0.11	IRX3	iroquois homeobox 3	532	0.83
chr7_114054549_114054700	0.11	FOXP2	forkhead box P2	295	0.93
chr12_56075239_56075869	0.11	METTL7B	methyltransferase like 7B	224	0.86
chr1_33455162_33455432	0.11	RP1-117O3.2		2621	0.21
chr3_156468450_156468930	0.11	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	69735	0.11
chr4_108817732_108818165	0.11	SGMS2	sphingomyelin synthase 2	2544	0.25
chr5_98112819_98113202	0.11	RGMB	repulsive guidance molecule family member b	3671	0.26
chr10_62724503_62724836	0.11	RHOBTB1	Rho-related BTB domain containing 1	20664	0.25
chr5_171380881_171381289	0.11	FBXW11	F-box and WD repeat domain containing 11	23675	0.23
chr4_141013667_141013926	0.11	RP11-392B6.1		35373	0.19
chr9_129467204_129467355	0.11	ENSG00000266403	.	13333	0.21
chr9_73539563_73539988	0.11	TRPM3	transient receptor potential cation channel, subfamily M, member 3	55801	0.16
chr15_40395062_40395658	0.11	BMF	Bcl2 modifying factor	2927	0.21
chr9_23850343_23850766	0.11	ELAVL2	ELAV like neuron-specific RNA binding protein 2	24219	0.29
chr2_202015949_202016344	0.11	CFLAR-AS1	CFLAR antisense RNA 1	263	0.88

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.2	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.2	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.3	GO:0036303	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0031223	auditory behavior(GO:0031223)
0.0	0.3	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.2	GO:0000090	mitotic anaphase(GO:0000090)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.2	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.0	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.2	GO:0051058	negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0	0.0	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.0	GO:0072193	positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0031268	pseudopodium organization(GO:0031268)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:0035284	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0008595	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.1	GO:0014009	glial cell proliferation(GO:0014009)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0031392	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0019614	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.0	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:0048146	positive regulation of fibroblast proliferation(GO:0048146)
0.0	0.0	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.0	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0031122	cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005587	collagen type IV trimer(GO:0005587)
0.1	0.2	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.0	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.2	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0044620	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.2	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	PID SHP2 PATHWAY	SHP2 signaling
0.5	NABA COLLAGENS	Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation