Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
Navigation
Downloads
Logo

Results for NKX2-6

Z-value: 0.51

Motif logo

logo of

Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NK2 homeobox 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr8_23562532_23562683NKX2-613150.3590280.742.2e-02Click!
chr8_23563794_23563945NKX2-6530.935410-0.462.2e-01Click!
chr8_23562338_23562489NKX2-615090.3230560.245.4e-01Click!
chr8_23563950_23564574NKX2-61510.764890-0.039.4e-01Click!

Activity of the NKX2-6 motif across conditions

Conditions sorted by the z-value of the NKX2-6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_132315920_132316071 0.31 ACKR4
 atypical chemokine receptor 4
 86
 0.98
chr2_175197281_175197503 0.30 SP9
 Sp9 transcription factor
 2282
 0.26
chr8_106743100_106743756 0.28 RP11-642D21.2
45435
 0.16
chr22_36310772_36312004 0.27 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 23557
 0.25
chr12_20523872_20524102 0.26 RP11-284H19.1
791
 0.64
chr3_127540841_127541975 0.26 MGLL
 monoglyceride lipase
 214
 0.96
chr7_119912758_119913222 0.25 KCND2
 potassium voltage-gated channel, Shal-related subfamily, member 2
 732
 0.81
chr11_121968562_121968780 0.23 ENSG00000207971
 .
 1881
 0.27
chr6_28175291_28175856 0.22 ZSCAN9
 zinc finger and SCAN domain containing 9
 17091
 0.12
chr2_159610172_159610621 0.22 AC005042.4
18882
 0.21
chr7_116142833_116142984 0.22 CAV2
 caveolin 2
 3074
 0.2
chr6_72129322_72130506 0.21 ENSG00000207827
 .
 16590
 0.22
chr17_57229359_57229924 0.21 SKA2
 spindle and kinetochore associated complex subunit 2
 479
 0.57
chr6_56614643_56614951 0.21 DST
 dystonin
 35880
 0.21
chr11_69458516_69459047 0.21 CCND1
 cyclin D1
 2807
 0.29
chr7_80547175_80548098 0.20 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 863
 0.76
chr6_86114788_86115158 0.20 NT5E
 5'-nucleotidase, ecto (CD73)
 44836
 0.19
chr7_15725092_15725754 0.20 MEOX2
 mesenchyme homeobox 2
 1014
 0.63
chr4_169799680_169799831 0.20 ENSG00000201176
 .
 6751
 0.22
chr8_494094_494251 0.19 TDRP
 testis development related protein
 665
 0.79
chr18_61554936_61555215 0.19 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
 82
 0.97
chr12_13350846_13351208 0.19 EMP1
 epithelial membrane protein 1
 1307
 0.55
chr1_158969828_158970040 0.19 IFI16
 interferon, gamma-inducible protein 16
 176
 0.96
chr20_19916034_19916185 0.19 RIN2
 Ras and Rab interactor 2
 45899
 0.15
chr21_31311288_31312406 0.19 GRIK1
 glutamate receptor, ionotropic, kainate 1
 3
 0.99
chr20_6749993_6750220 0.19 BMP2
 bone morphogenetic protein 2
 1795
 0.51
chr10_4719640_4719886 0.18 AKR1E2
 aldo-keto reductase family 1, member E2
 109058
 0.07
chr4_74975461_74975696 0.18 CXCL2
 chemokine (C-X-C motif) ligand 2
 10568
 0.16
chr20_13976647_13977145 0.18 SEL1L2
 sel-1 suppressor of lin-12-like 2 (C. elegans)
 193
 0.78
chr7_13959407_13959706 0.18 ETV1
 ets variant 1
 66510
 0.14
chr9_86916681_86916945 0.18 RP11-380F14.2
23679
 0.22
chr8_8154312_8154463 0.17 ALG1L13P
 asparagine-linked glycosylation 1-like 13, pseudogene
 55454
 0.11
chr4_180980346_180980880 0.17 NA
 NA
 > 106
 NA
chr4_23890131_23890306 0.17 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 1440
 0.57
chr2_226896266_226896823 0.17 NYAP2
 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
 622947
 0.0
chr1_13910795_13911459 0.17 PDPN
 podoplanin
 362
 0.87
chr1_167721376_167721626 0.17 MPZL1
 myelin protein zero-like 1
 13306
 0.23
chr8_6691754_6692464 0.17 DEFB1
 defensin, beta 1
 43435
 0.14
chr11_16947220_16947414 0.17 PLEKHA7
 pleckstrin homology domain containing, family A member 7
 44412
 0.12
chr2_216297601_216297993 0.16 FN1
 fibronectin 1
 2993
 0.27
chrX_3264180_3264467 0.16 MXRA5
 matrix-remodelling associated 5
 359
 0.92
chr8_37350646_37351319 0.16 RP11-150O12.6
23557
 0.24
chr13_52165265_52165666 0.16 ENSG00000242893
 .
 2886
 0.18
chr10_16909529_16909705 0.16 RSU1
 Ras suppressor protein 1
 50090
 0.17
chr3_49447935_49448923 0.16 RHOA
 ras homolog family member A
 932
 0.32
chr8_38857241_38857490 0.16 ADAM9
 ADAM metallopeptidase domain 9
 2860
 0.19
chr1_162534114_162534517 0.16 UAP1
 UDP-N-acteylglucosamine pyrophosphorylase 1
 1512
 0.34
chr8_87934784_87934935 0.16 CNBD1
 cyclic nucleotide binding domain containing 1
 56186
 0.17
chr15_83951840_83952048 0.16 BNC1
 basonuclin 1
 127
 0.97
chr12_124990844_124991534 0.16 NCOR2
 nuclear receptor corepressor 2
 11391
 0.3
chr14_71838527_71838748 0.16 ENSG00000207444
 .
 26417
 0.18
chr13_110957949_110958238 0.16 COL4A2
 collagen, type IV, alpha 2
 66
 0.97
chr4_80572253_80572434 0.15 OR7E94P
 olfactory receptor, family 7, subfamily E, member 94 pseudogene
 63059
 0.15
chr1_179110770_179111258 0.15 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
 1165
 0.52
chr10_95227944_95228273 0.15 MYOF
 myoferlin
 13843
 0.19
chr8_91782901_91783052 0.15 NECAB1
 N-terminal EF-hand calcium binding protein 1
 20802
 0.19
chr8_30668680_30668831 0.15 PPP2CB
 protein phosphatase 2, catalytic subunit, beta isozyme
 963
 0.63
chr4_129998585_129998736 0.15 C4orf33
 chromosome 4 open reading frame 33
 15812
 0.24
chr8_104090727_104091208 0.15 ENSG00000265667
 .
 13982
 0.15
chr7_91923432_91923918 0.15 ANKIB1
 ankyrin repeat and IBR domain containing 1
 101
 0.97
chr1_214723042_214723197 0.15 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 1447
 0.54
chr5_158611818_158612659 0.15 RNF145
 ring finger protein 145
 22404
 0.16
chr7_78398482_78399243 0.15 MAGI2
 membrane associated guanylate kinase, WW and PDZ domain containing 2
 1534
 0.56
chr5_107041117_107041487 0.15 ENSG00000239708
 .
 29465
 0.21
chrX_19716439_19716715 0.15 SH3KBP1
 SH3-domain kinase binding protein 1
 27461
 0.25
chr9_97811337_97811671 0.15 ENSG00000207563
 .
 35986
 0.11
chr5_158126537_158126688 0.15 CTD-2363C16.1
283402
 0.01
chr3_29327656_29328192 0.15 RBMS3-AS3
 RBMS3 antisense RNA 3
 4293
 0.26
chr13_24121051_24121276 0.15 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 23346
 0.25
chr3_99766860_99767059 0.15 FILIP1L
 filamin A interacting protein 1-like
 66398
 0.1
chr4_157891142_157892336 0.15 PDGFC
 platelet derived growth factor C
 316
 0.91
chr6_56406612_56407191 0.14 DST
 dystonin
 68113
 0.13
chr7_12663902_12664053 0.14 SCIN
 scinderin
 19839
 0.21
chr4_85886471_85886934 0.14 WDFY3
 WD repeat and FYVE domain containing 3
 801
 0.75
chr10_102921756_102921944 0.14 RP11-31L23.3
22382
 0.12
chr7_27274920_27275071 0.14 EVX1
 even-skipped homeobox 1
 7169
 0.1
chr10_51574745_51574998 0.14 NCOA4
 nuclear receptor coactivator 4
 1414
 0.4
chr1_16466376_16466578 0.14 RP11-276H7.2
15229
 0.11
chr15_59598169_59598320 0.14 RP11-429D19.1
34883
 0.11
chrX_10602528_10602751 0.14 MID1
 midline 1 (Opitz/BBB syndrome)
 13965
 0.27
chr22_43017042_43017193 0.14 ENSG00000270022
 .
 5867
 0.12
chr12_3034547_3034860 0.14 ENSG00000238689
 .
 3428
 0.16
chr7_82071524_82071810 0.14 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 1364
 0.61
chr14_59949074_59949274 0.14 L3HYPDH
 L-3-hydroxyproline dehydratase (trans-)
 1229
 0.4
chr11_121972599_121972750 0.14 RP11-166D19.1
200
 0.92
chr5_171269419_171269604 0.14 SMIM23
 small integral membrane protein 23
 56621
 0.13
chr1_206687074_206687508 0.14 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 6412
 0.15
chr2_192710069_192710427 0.14 AC098617.1
1017
 0.51
chr19_6103641_6103897 0.14 CTB-66B24.1
5564
 0.15
chr6_18053801_18053981 0.14 KIF13A
 kinesin family member 13A
 66037
 0.11
chr8_37555995_37556200 0.14 ZNF703
 zinc finger protein 703
 2828
 0.18
chr12_59309288_59309823 0.14 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 1191
 0.55
chr1_200710499_200710966 0.14 CAMSAP2
 calmodulin regulated spectrin-associated protein family, member 2
 1825
 0.44
chr15_68573802_68573977 0.14 FEM1B
 fem-1 homolog b (C. elegans)
 1592
 0.39
chr15_72529055_72529849 0.14 PKM
 pyruvate kinase, muscle
 5288
 0.17
chr3_49169788_49170138 0.14 LAMB2
 laminin, beta 2 (laminin S)
 490
 0.65
chr20_47299051_47299422 0.13 ENSG00000251876
 .
 56749
 0.16
chr7_102990167_102990648 0.13 PSMC2
 proteasome (prosome, macropain) 26S subunit, ATPase, 2
 2297
 0.25
chr3_61560941_61561100 0.13 PTPRG
 protein tyrosine phosphatase, receptor type, G
 13435
 0.31
chr1_101359369_101359680 0.13 EXTL2
 exostosin-like glycosyltransferase 2
 696
 0.48
chr1_70688549_70688700 0.13 SRSF11
 serine/arginine-rich splicing factor 11
 1479
 0.33
chr5_16934966_16935117 0.13 MYO10
 myosin X
 1006
 0.59
chr9_20511940_20512213 0.13 ENSG00000264941
 .
 9736
 0.23
chr14_65928823_65928974 0.13 ENSG00000207781
 .
 8922
 0.25
chr12_56513564_56513771 0.13 RP11-603J24.6
56
 0.9
chr5_141278602_141278753 0.13 PCDH1
 protocadherin 1
 19866
 0.14
chr6_155005040_155005564 0.13 SCAF8
 SR-related CTD-associated factor 8
 49157
 0.17
chr1_109824775_109824999 0.13 PSRC1
 proline/serine-rich coiled-coil 1
 586
 0.7
chr3_11551023_11551396 0.13 VGLL4
 vestigial like 4 (Drosophila)
 59189
 0.14
chr12_105651079_105651410 0.13 APPL2
 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
 21228
 0.19
chr6_119667569_119668515 0.13 MAN1A1
 mannosidase, alpha, class 1A, member 1
 2859
 0.34
chr4_114214241_114214392 0.13 ANK2
 ankyrin 2, neuronal
 178
 0.97
chr7_27205863_27206297 0.13 HOXA9
 homeobox A9
 931
 0.25
chr2_127822596_127822803 0.13 BIN1
 bridging integrator 1
 41878
 0.16
chr7_17030060_17030455 0.13 AGR3
 anterior gradient 3
 108646
 0.07
chr9_21555046_21555197 0.13 MIR31HG
 MIR31 host gene (non-protein coding)
 4547
 0.21
chr19_16403865_16404198 0.13 CTD-2562J15.6
355
 0.85
chr2_17722476_17722627 0.13 VSNL1
 visinin-like 1
 124
 0.98
chr1_150481112_150481644 0.12 ECM1
 extracellular matrix protein 1
 795
 0.48
chr12_56916774_56917003 0.12 RBMS2
 RNA binding motif, single stranded interacting protein 2
 1105
 0.41
chr2_31360151_31360442 0.12 GALNT14
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
 591
 0.81
chr9_97811962_97812255 0.12 ENSG00000207563
 .
 35382
 0.12
chr5_151065179_151065606 0.12 SPARC
 secreted protein, acidic, cysteine-rich (osteonectin)
 601
 0.67
chr12_6494464_6494615 0.12 LTBR
 lymphotoxin beta receptor (TNFR superfamily, member 3)
 254
 0.87
chr22_43386709_43386953 0.12 PACSIN2
 protein kinase C and casein kinase substrate in neurons 2
 11615
 0.21
chr11_114861879_114862030 0.12 ENSG00000252870
 .
 137139
 0.05
chr9_97768076_97768588 0.12 C9orf3
 chromosome 9 open reading frame 3
 1054
 0.55
chr5_82767889_82768074 0.12 VCAN
 versican
 237
 0.96
chr5_54916685_54916836 0.12 SLC38A9
 solute carrier family 38, member 9
 71688
 0.1
chr10_35102956_35103650 0.12 PARD3
 par-3 family cell polarity regulator
 946
 0.5
chr13_113689501_113689756 0.12 MCF2L
 MCF.2 cell line derived transforming sequence-like
 9348
 0.15
chr2_1734119_1734469 0.12 PXDN
 peroxidasin homolog (Drosophila)
 13920
 0.26
chr17_4762663_4762814 0.12 ENSG00000263599
 .
 16183
 0.08
chr7_101596567_101596967 0.12 CTB-181H17.1
6629
 0.27
chr1_170630999_170631537 0.12 PRRX1
 paired related homeobox 1
 1007
 0.68
chr10_62541267_62541606 0.12 CDK1
 cyclin-dependent kinase 1
 1525
 0.51
chr11_61456591_61456863 0.12 DAGLA
 diacylglycerol lipase, alpha
 8822
 0.18
chr6_16339042_16339210 0.12 ENSG00000265642
 .
 89628
 0.08
chr12_89846997_89847148 0.12 POC1B
 POC1 centriolar protein B
 43962
 0.13
chr2_46546253_46546404 0.12 EPAS1
 endothelial PAS domain protein 1
 21787
 0.24
chr3_11755297_11755448 0.12 VGLL4
 vestigial like 4 (Drosophila)
 3361
 0.34
chr14_102446484_102446635 0.12 DYNC1H1
 dynein, cytoplasmic 1, heavy chain 1
 15694
 0.19
chr13_43842946_43843190 0.12 ENOX1
 ecto-NOX disulfide-thiol exchanger 1
 92145
 0.1
chr7_107221551_107221702 0.12 BCAP29
 B-cell receptor-associated protein 29
 422
 0.69
chr7_100464814_100466140 0.12 TRIP6
 thyroid hormone receptor interactor 6
 717
 0.47
chr1_98514169_98514606 0.12 ENSG00000225206
 .
 2660
 0.42
chr6_18389672_18389881 0.12 RNF144B
 ring finger protein 144B
 2195
 0.34
chr14_92997841_92998087 0.12 RIN3
 Ras and Rab interactor 3
 17816
 0.26
chr5_149462966_149463221 0.12 CSF1R
 colony stimulating factor 1 receptor
 2897
 0.21
chr5_78204137_78204521 0.12 ARSB
 arylsulfatase B
 77279
 0.11
chr2_47527627_47527778 0.12 EPCAM
 epithelial cell adhesion molecule
 44595
 0.13
chr4_141018823_141018974 0.12 RP11-392B6.1
30271
 0.2
chr1_212812342_212812619 0.12 RP11-338C15.5
12367
 0.14
chr14_68613241_68613392 0.12 ENSG00000244677
 .
 3309
 0.29
chr3_4624343_4624494 0.12 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
 66242
 0.12
chr15_92438505_92438656 0.12 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 41229
 0.19
chrX_31284819_31285011 0.11 DMD
 dystrophin
 59
 0.99
chr2_159992813_159993143 0.11 ENSG00000202029
 .
 109324
 0.06
chr1_178269315_178269642 0.11 RASAL2
 RAS protein activator like 2
 41128
 0.2
chr4_140793537_140793902 0.11 MAML3
 mastermind-like 3 (Drosophila)
 17487
 0.25
chr8_38585652_38586394 0.11 TACC1
 transforming, acidic coiled-coil containing protein 1
 82
 0.97
chr5_61681454_61681605 0.11 DIMT1
 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
 18196
 0.17
chr1_57043984_57044408 0.11 PPAP2B
 phosphatidic acid phosphatase type 2B
 1045
 0.66
chr12_110720958_110721647 0.11 ATP2A2
 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
 1816
 0.41
chr2_153382153_153382407 0.11 FMNL2
 formin-like 2
 93812
 0.09
chr6_108486676_108487297 0.11 OSTM1
 osteopetrosis associated transmembrane protein 1
 58
 0.78
chr7_27236053_27236457 0.11 HOTTIP
 HOXA distal transcript antisense RNA
 1939
 0.13
chr3_177978802_177979100 0.11 KCNMB2
 potassium large conductance calcium-activated channel, subfamily M, beta member 2
 11769
 0.3
chr3_99360396_99360669 0.11 COL8A1
 collagen, type VIII, alpha 1
 3078
 0.35
chr20_6764834_6765429 0.11 BMP2
 bone morphogenetic protein 2
 16820
 0.28
chr19_10736478_10736985 0.11 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 530
 0.65
chr4_113803321_113803472 0.11 RP11-119H12.6
90
 0.98
chr16_54464970_54465224 0.11 ENSG00000264079
 .
 118211
 0.06
chr4_20195598_20195749 0.11 SLIT2
 slit homolog 2 (Drosophila)
 59210
 0.17
chr2_97593411_97593614 0.11 ENSG00000252845
 .
 29040
 0.12
chr9_117439582_117439814 0.11 ENSG00000272241
 .
 60871
 0.1
chr10_17241830_17242242 0.11 TRDMT1
 tRNA aspartic acid methyltransferase 1
 1543
 0.37
chr5_139968434_139968585 0.11 ENSG00000200235
 .
 9257
 0.08
chr12_118745072_118745584 0.11 TAOK3
 TAO kinase 3
 51464
 0.15
chr22_29106631_29107007 0.11 CHEK2
 checkpoint kinase 2
 1100
 0.47
chr3_188149558_188149830 0.11 LPP-AS1
 LPP antisense RNA 1
 136760
 0.05
chr12_54778714_54778870 0.11 ZNF385A
 zinc finger protein 385A
 256
 0.84
chr12_13408941_13409103 0.11 EMP1
 epithelial membrane protein 1
 44577
 0.17
chrX_107683395_107684019 0.11 COL4A5
 collagen, type IV, alpha 5
 595
 0.63
chr1_245331414_245331723 0.11 KIF26B
 kinesin family member 26B
 13281
 0.2
chr16_54321004_54321411 0.11 IRX3
 iroquois homeobox 3
 532
 0.83
chr7_114054549_114054700 0.11 FOXP2
 forkhead box P2
 295
 0.93
chr12_56075239_56075869 0.11 METTL7B
 methyltransferase like 7B
 224
 0.86
chr1_33455162_33455432 0.11 RP1-117O3.2
2621
 0.21
chr3_156468450_156468930 0.11 TIPARP
 TCDD-inducible poly(ADP-ribose) polymerase
 69735
 0.11
chr4_108817732_108818165 0.11 SGMS2
 sphingomyelin synthase 2
 2544
 0.25
chr5_98112819_98113202 0.11 RGMB
 repulsive guidance molecule family member b
 3671
 0.26
chr10_62724503_62724836 0.11 RHOBTB1
 Rho-related BTB domain containing 1
 20664
 0.25
chr5_171380881_171381289 0.11 FBXW11
 F-box and WD repeat domain containing 11
 23675
 0.23
chr4_141013667_141013926 0.11 RP11-392B6.1
35373
 0.19
chr9_129467204_129467355 0.11 ENSG00000266403
 .
 13333
 0.21
chr9_73539563_73539988 0.11 TRPM3
 transient receptor potential cation channel, subfamily M, member 3
 55801
 0.16
chr15_40395062_40395658 0.11 BMF
 Bcl2 modifying factor
 2927
 0.21
chr9_23850343_23850766 0.11 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
 24219
 0.29
chr2_202015949_202016344 0.11 CFLAR-AS1
 CFLAR antisense RNA 1
 263
 0.88

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.2 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.2 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.3 GO:0036303 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.3 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.2 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.2 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.0 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.2 GO:0051058 negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0072193 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.0 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.0 GO:0039656 modulation by virus of host gene expression(GO:0039656)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.1 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.1 GO:0014009 glial cell proliferation(GO:0014009)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0050932 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0031392 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0019614 phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.0 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.2 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.0 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.0 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0031122 cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.0 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0044620 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.0 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.0 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.0 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.0 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.0 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation