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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for NKX2-8

Z-value: 1.62

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Transcription factors associated with NKX2-8

Gene Symbol	Gene ID	Gene Info
NKX2-8 Ensembl NCBI GeneCards UniProt	ENSG00000136327.6	NK2 homeobox 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr14_37050074_37050263	NKX2-8	1644	0.340731	-0.67	4.8e-02	Click!
chr14_37050333_37050591	NKX2-8	1350	0.401276	-0.60	8.5e-02	Click!
chr14_37050633_37050993	NKX2-8	999	0.513090	-0.57	1.1e-01	Click!
chr14_37049810_37049961	NKX2-8	1927	0.300607	-0.55	1.3e-01	Click!
chr14_37051349_37051714	NKX2-8	281	0.898225	-0.48	1.9e-01	Click!

Activity of the NKX2-8 motif across conditions

Conditions sorted by the z-value of the NKX2-8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_263385_263906	1.01	AC108004.3		169	0.93
chr10_112643444_112643765	0.64	PDCD4-AS1	PDCD4 antisense RNA 1	11613	0.13
chr17_65524931_65525141	0.57	CTD-2653B5.1		4439	0.23
chr2_122732850_122733191	0.42	TSN	translin	219273	0.02
chr17_40426926_40427118	0.42	STAT5B	signal transducer and activator of transcription 5B	1402	0.27
chr11_1874347_1875032	0.40	LSP1	lymphocyte-specific protein 1	489	0.65
chr3_33061158_33061309	0.39	CCR4	chemokine (C-C motif) receptor 4	68167	0.09
chr2_152214178_152214367	0.38	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	166	0.95
chr7_142424971_142425130	0.37	PRSS1	protease, serine, 1 (trypsin 1)	32269	0.16
chr8_21770420_21771232	0.37	DOK2	docking protein 2, 56kDa	348	0.88
chr18_67070028_67070179	0.36	DOK6	docking protein 6	1812	0.52
chr10_88280283_88281468	0.36	WAPAL	wings apart-like homolog (Drosophila)	697	0.48
chr19_42057824_42058331	0.35	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	2191	0.27
chr2_238321638_238321789	0.35	COL6A3	collagen, type VI, alpha 3	1078	0.55
chr3_141516104_141516959	0.35	ENSG00000265391	.	9778	0.19
chr12_120702506_120703431	0.35	PXN	paxillin	595	0.62
chr15_52513775_52514010	0.35	GNB5	guanine nucleotide binding protein (G protein), beta 5	30326	0.14
chr3_121379230_121379471	0.34	HCLS1	hematopoietic cell-specific Lyn substrate 1	395	0.81
chr1_101088714_101088865	0.34	GPR88	G protein-coupled receptor 88	85096	0.08
chr2_175710954_175711206	0.33	CHN1	chimerin 1	53	0.98
chr6_159076249_159076519	0.32	SYTL3	synaptotagmin-like 3	5338	0.2
chr11_6766181_6766335	0.31	GVINP1	GTPase, very large interferon inducible pseudogene 1	23147	0.11
chr13_40113513_40113664	0.31	LHFP	lipoma HMGIC fusion partner	63720	0.12
chr5_38298037_38298188	0.31	EGFLAM-AS4	EGFLAM antisense RNA 4	7024	0.22
chr7_961818_962008	0.31	ADAP1	ArfGAP with dual PH domains 1	1387	0.35
chrX_147649111_147649262	0.31	AFF2-IT1	AFF2 intronic transcript 1 (non-protein coding)	20787	0.23
chr2_105471048_105471431	0.31	POU3F3	POU class 3 homeobox 3	730	0.47
chr9_117149358_117150269	0.31	AKNA	AT-hook transcription factor	430	0.85
chr1_1830918_1831069	0.30	RP1-140A9.1		8083	0.13
chr1_65096460_65096611	0.30	ENSG00000264470	.	51005	0.17
chr19_3178230_3178381	0.30	S1PR4	sphingosine-1-phosphate receptor 4	431	0.74
chr13_31311278_31311505	0.30	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	1746	0.48
chr6_159074554_159074705	0.30	SYTL3	synaptotagmin-like 3	3583	0.22
chr19_49250256_49250484	0.30	IZUMO1	izumo sperm-egg fusion 1	204	0.86
chr7_8011713_8012079	0.29	AC006042.7		2362	0.25
chr6_164133373_164133746	0.29	ENSG00000266128	.	128034	0.06
chr15_68872500_68872651	0.29	CORO2B	coronin, actin binding protein, 2B	1002	0.69
chr4_7878163_7878536	0.28	AFAP1	actin filament associated protein 1	4309	0.28
chr3_57051588_57051739	0.28	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	40260	0.14
chr8_1321053_1321283	0.28	DLGAP2	discs, large (Drosophila) homolog-associated protein 2	128364	0.06
chr8_126958884_126959035	0.28	ENSG00000206695	.	45764	0.2
chr10_63807388_63807623	0.28	ARID5B	AT rich interactive domain 5B (MRF1-like)	1465	0.53
chr22_18121057_18121389	0.28	BCL2L13	BCL2-like 13 (apoptosis facilitator)	133	0.95
chrX_12991784_12992037	0.28	TMSB4X	thymosin beta 4, X-linked	1317	0.51
chr12_124872056_124872210	0.28	NCOR2	nuclear receptor corepressor 2	1237	0.6
chr20_60099861_60100012	0.28	CDH4	cadherin 4, type 1, R-cadherin (retinal)	74898	0.12
chr8_122650591_122650784	0.28	HAS2-AS1	HAS2 antisense RNA 1	846	0.65
chrY_21906956_21907224	0.28	KDM5D	lysine (K)-specific demethylase 5D	265	0.96
chr12_50492869_50493020	0.28	GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	4658	0.12
chr16_18814748_18814911	0.28	RP11-1035H13.2		424	0.72
chr7_105515013_105515164	0.27	ATXN7L1	ataxin 7-like 1	1835	0.48
chr22_50523508_50523892	0.27	MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	12	0.97
chr5_95159156_95159584	0.27	GLRX	glutaredoxin (thioltransferase)	661	0.64
chr20_62478644_62478873	0.27	AL158091.1	Protein LOC100509861	3485	0.11
chr3_98252105_98252256	0.27	GPR15	G protein-coupled receptor 15	1437	0.33
chr4_185744057_185744208	0.27	ACSL1	acyl-CoA synthetase long-chain family member 1	3056	0.24
chrY_2709555_2710183	0.27	RPS4Y1	ribosomal protein S4, Y-linked 1	92	0.98
chr22_18260050_18260218	0.26	BID	BH3 interacting domain death agonist	2703	0.26
chr12_69928827_69929101	0.26	FRS2	fibroblast growth factor receptor substrate 2	4361	0.23
chr13_27847009_27847160	0.26	RASL11A	RAS-like, family 11, member A	2620	0.18
chr11_64627415_64627663	0.26	CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	15498	0.09
chr11_6764514_6764763	0.26	GVINP1	GTPase, very large interferon inducible pseudogene 1	21527	0.11
chr20_62271866_62272113	0.26	STMN3	stathmin-like 3	12130	0.09
chr18_19262523_19262951	0.26	ENSG00000221493	.	734	0.52
chr18_25667148_25667420	0.26	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	9909	0.32
chr17_64301105_64301326	0.25	PRKCA	protein kinase C, alpha	2271	0.31
chr4_4862278_4863048	0.25	MSX1	msh homeobox 1	1270	0.58
chr20_31261222_31261541	0.25	COMMD7	COMM domain containing 7	69831	0.08
chr19_14543678_14543986	0.25	PKN1	protein kinase N1	33	0.96
chr14_22953281_22953432	0.25	ENSG00000251002	.	1408	0.24
chr2_10522774_10523051	0.25	HPCAL1	hippocalcin-like 1	37235	0.15
chr16_88767040_88767399	0.25	RNF166	ring finger protein 166	208	0.83
chr18_22827544_22827695	0.25	ZNF521	zinc finger protein 521	16125	0.27
chr16_50401597_50402736	0.25	RP11-21B23.1		325	0.64
chr1_84902979_84903163	0.25	DNASE2B	deoxyribonuclease II beta	29158	0.16
chr4_100782467_100782618	0.25	LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	32991	0.16
chr1_32716475_32716711	0.24	LCK	lymphocyte-specific protein tyrosine kinase	247	0.82
chr1_244300887_244301112	0.24	ENSG00000244066	.	33765	0.2
chr6_113012091_113012242	0.24	ENSG00000252215	.	158782	0.04
chr1_154382438_154382721	0.24	RP11-350G8.5		3539	0.16
chr15_48935948_48936126	0.24	FBN1	fibrillin 1	1881	0.46
chr1_6846959_6847133	0.24	CAMTA1	calmodulin binding transcription activator 1	1455	0.35
chr20_36888706_36889089	0.24	KIAA1755	KIAA1755	277	0.53
chr6_8017649_8017800	0.24	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	8922	0.26
chr6_112359418_112359743	0.24	WISP3	WNT1 inducible signaling pathway protein 3	15695	0.2
chr3_104469354_104469505	0.24	ALCAM	activated leukocyte cell adhesion molecule	616324	0.0
chr10_70849708_70849969	0.24	SRGN	serglycin	1964	0.33
chr13_73804562_73804713	0.24	ENSG00000206697	.	3353	0.31
chr8_94507892_94508285	0.24	ENSG00000222416	.	54583	0.14
chr2_135485269_135485420	0.24	TMEM163	transmembrane protein 163	8774	0.29
chr13_99195211_99195547	0.23	STK24	serine/threonine kinase 24	21127	0.2
chr12_12889608_12890123	0.23	APOLD1	apolipoprotein L domain containing 1	11000	0.14
chr14_56777842_56777993	0.23	TMEM260	transmembrane protein 260	177155	0.03
chr1_85723117_85723268	0.23	C1orf52	chromosome 1 open reading frame 52	2124	0.23
chr5_35853259_35853410	0.23	IL7R	interleukin 7 receptor	537	0.79
chr1_224301513_224301771	0.23	FBXO28	F-box protein 28	147	0.95
chr16_23837804_23837955	0.23	PRKCB	protein kinase C, beta	9443	0.23
chr17_72808451_72808602	0.23	TMEM104	transmembrane protein 104	35867	0.08
chr2_201171688_201172904	0.23	SPATS2L	spermatogenesis associated, serine-rich 2-like	701	0.76
chr10_111725406_111725649	0.23	RP11-451M19.3	Uncharacterized protein	11878	0.19
chr15_33383427_33383578	0.23	FMN1	formin 1	23139	0.25
chr4_77818732_77819690	0.23	SOWAHB	sosondowah ankyrin repeat domain family member B	209	0.95
chr6_2222723_2222882	0.23	GMDS	GDP-mannose 4,6-dehydratase	23124	0.28
chr13_75897142_75897293	0.23	TBC1D4	TBC1 domain family, member 4	18450	0.24
chr4_90225194_90225464	0.22	GPRIN3	GPRIN family member 3	3832	0.36
chr11_104914233_104914622	0.22	CARD16	caspase recruitment domain family, member 16	1607	0.35
chr1_225655628_225655947	0.22	RP11-496N12.6		2742	0.3
chr2_136577729_136578391	0.22	AC011893.3		299	0.89
chr16_50091812_50091963	0.22	HEATR3	HEAT repeat containing 3	7965	0.16
chr16_11085461_11085694	0.22	CLEC16A	C-type lectin domain family 16, member A	47139	0.1
chr8_134085908_134086059	0.22	SLA	Src-like-adaptor	13380	0.24
chr6_143177934_143178085	0.22	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	19825	0.26
chr14_93118654_93119048	0.22	RIN3	Ras and Rab interactor 3	5	0.99
chr12_21926599_21927146	0.22	KCNJ8	potassium inwardly-rectifying channel, subfamily J, member 8	883	0.57
chr10_31610330_31610730	0.22	ZEB1	zinc finger E-box binding homeobox 1	449	0.74
chr1_248020847_248021774	0.22	TRIM58	tripartite motif containing 58	809	0.49
chr13_74637272_74637666	0.22	KLF12	Kruppel-like factor 12	68283	0.14
chr7_7856053_7856204	0.22	RPA3-AS1	RPA3 antisense RNA 1	44136	0.16
chr10_15296464_15296906	0.22	RP11-25G10.2		17194	0.24
chr2_201983400_201983976	0.22	CFLAR	CASP8 and FADD-like apoptosis regulator	474	0.74
chr14_56890698_56890849	0.22	TMEM260	transmembrane protein 260	64299	0.14
chr2_158291882_158292250	0.22	CYTIP	cytohesin 1 interacting protein	3860	0.26
chr19_10654611_10655216	0.22	ATG4D	autophagy related 4D, cysteine peptidase	46	0.94
chr5_76372662_76373578	0.22	ENSG00000238961	.	3276	0.17
chr7_28205881_28206089	0.22	JAZF1-AS1	JAZF1 antisense RNA 1	13956	0.2
chr13_48806691_48807140	0.22	ITM2B	integral membrane protein 2B	379	0.91
chr3_37030103_37030254	0.22	EPM2AIP1	EPM2A (laforin) interacting protein 1	4617	0.18
chr4_1864388_1864636	0.22	LETM1	leucine zipper-EF-hand containing transmembrane protein 1	6538	0.16
chr14_89924973_89925124	0.21	FOXN3	forkhead box N3	35347	0.14
chr4_185779027_185779178	0.21	ENSG00000266698	.	6838	0.2
chr2_69001356_69001782	0.21	ARHGAP25	Rho GTPase activating protein 25	364	0.9
chr14_91698668_91698819	0.21	CTD-2547L24.3	HCG1816139; Uncharacterized protein	10360	0.16
chr1_206644983_206645179	0.21	IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	1243	0.39
chr2_3469746_3469998	0.21	TRAPPC12	trafficking protein particle complex 12	428	0.81
chr5_90675264_90675506	0.21	ARRDC3	arrestin domain containing 3	3791	0.3
chr3_65891825_65891976	0.21	MAGI1-AS1	MAGI1 antisense RNA 1	12409	0.21
chr7_120643096_120643247	0.21	CPED1	cadherin-like and PC-esterase domain containing 1	13495	0.2
chrX_148607315_148607561	0.21	IDS	iduronate 2-sulfatase	4803	0.16
chr10_130834433_130834622	0.21	MGMT	O-6-methylguanine-DNA methyltransferase	430921	0.01
chr21_36419709_36420003	0.21	RUNX1	runt-related transcription factor 1	1606	0.56
chr14_90606852_90607152	0.21	ENSG00000201351	.	36564	0.18
chr18_60128151_60128302	0.21	ZCCHC2	zinc finger, CCHC domain containing 2	62014	0.12
chr6_106536140_106536635	0.21	PRDM1	PR domain containing 1, with ZNF domain	932	0.64
chr1_160676943_160677601	0.21	CD48	CD48 molecule	4321	0.18
chr6_24448897_24449048	0.21	GPLD1	glycosylphosphatidylinositol specific phospholipase D1	40878	0.12
chr8_67524543_67525469	0.21	MYBL1	v-myb avian myeloblastosis viral oncogene homolog-like 1	136	0.96
chr9_35649649_35650491	0.21	SIT1	signaling threshold regulating transmembrane adaptor 1	867	0.32
chr10_134755501_134756431	0.21	TTC40	tetratricopeptide repeat domain 40	123	0.98
chr9_134165447_134165667	0.21	PPAPDC3	phosphatidic acid phosphatase type 2 domain containing 3	358	0.87
chr1_65530319_65530470	0.20	ENSG00000199135	.	6203	0.2
chr7_111721329_111721542	0.20	DOCK4	dedicator of cytokinesis 4	77249	0.11
chr5_102729198_102729349	0.20	C5orf30	chromosome 5 open reading frame 30	134148	0.05
chr1_214491697_214491969	0.20	SMYD2	SET and MYND domain containing 2	12487	0.25
chr8_97399262_97399647	0.20	ENSG00000202095	.	43934	0.15
chr15_23931247_23932124	0.20	NDN	necdin, melanoma antigen (MAGE) family member	765	0.7
chr2_15233037_15233188	0.20	NBAS	neuroblastoma amplified sequence	97409	0.09
chr16_28996496_28996848	0.20	LAT	linker for activation of T cells	11	0.94
chr5_75826683_75826834	0.20	IQGAP2	IQ motif containing GTPase activating protein 2	16476	0.24
chr10_12491056_12491308	0.20	ENSG00000252118	.	7300	0.23
chr2_202671346_202671504	0.20	CDK15	cyclin-dependent kinase 15	37	0.97
chr10_118650978_118651144	0.20	ENO4	enolase family member 4	32516	0.18
chr20_53092813_53093232	0.20	DOK5	docking protein 5	765	0.8
chr3_181434209_181434555	0.20	SOX2	SRY (sex determining region Y)-box 2	4660	0.26
chr2_234395390_234395680	0.20	USP40	ubiquitin specific peptidase 40	2572	0.32
chr17_76117639_76118201	0.20	TMC6	transmembrane channel-like 6	909	0.44
chr22_37314565_37314716	0.20	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	3536	0.17
chr8_39770308_39770525	0.20	IDO1	indoleamine 2,3-dioxygenase 1	387	0.77
chr4_39482632_39482783	0.20	LIAS	lipoic acid synthetase	22015	0.12
chr11_114169173_114169324	0.20	NNMT	nicotinamide N-methyltransferase	375	0.89
chr1_150245669_150245859	0.20	C1orf54	chromosome 1 open reading frame 54	581	0.54
chr7_36312413_36312564	0.20	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	24265	0.16
chr11_64512499_64513555	0.20	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	99	0.95
chr16_3116517_3116777	0.20	IL32	interleukin 32	834	0.3
chr4_109056842_109056993	0.20	LEF1	lymphoid enhancer-binding factor 1	30540	0.19
chr13_99960207_99960358	0.20	GPR183	G protein-coupled receptor 183	623	0.75
chr19_6669805_6670171	0.20	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	140	0.94
chrX_10287863_10288014	0.20	ENSG00000222133	.	103199	0.08
chrX_68049582_68050726	0.20	EFNB1	ephrin-B1	1314	0.61
chr12_8696758_8696909	0.20	CLEC4E	C-type lectin domain family 4, member E	3274	0.19
chr2_218221905_218222056	0.20	ENSG00000251982	.	105701	0.08
chr6_112080632_112080854	0.20	FYN	FYN oncogene related to SRC, FGR, YES	377	0.91
chr11_122040052_122040217	0.20	ENSG00000207994	.	17118	0.17
chr3_42688506_42688657	0.19	ZBTB47	zinc finger and BTB domain containing 47	6595	0.11
chr2_65020078_65020229	0.19	ENSG00000253082	.	16915	0.18
chr4_141444785_141445124	0.19	ELMOD2	ELMO/CED-12 domain containing 2	358	0.87
chr4_138452878_138453572	0.19	PCDH18	protocadherin 18	340	0.94
chr2_7150911_7151062	0.19	RNF144A	ring finger protein 144A	13915	0.24
chr2_109802533_109802684	0.19	ENSG00000264934	.	44564	0.17
chr18_54741654_54741805	0.19	WDR7-OT1	WDR7 overlapping transcript 1 (non-protein coding)	46666	0.16
chr21_15112707_15112858	0.19	AL050303.1	Uncharacterized protein; cDNA FLJ43689 fis, clone TBAES2003550	59323	0.12
chr2_158298330_158298802	0.19	ENSG00000216054	.	504	0.79
chr14_101294998_101295174	0.19	AL117190.2		451	0.51
chr19_39109842_39110160	0.19	EIF3K	eukaryotic translation initiation factor 3, subunit K	150	0.8
chr12_92428651_92429384	0.19	C12orf79	chromosome 12 open reading frame 79	101780	0.07
chr12_9822383_9822619	0.19	CLEC2D	C-type lectin domain family 2, member D	152	0.93
chr9_16417414_16417894	0.19	BNC2	basonuclin 2	18716	0.25
chr3_60062649_60062918	0.19	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	105200	0.08
chr12_122729504_122729668	0.19	VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)	5126	0.17
chr3_145873792_145874131	0.19	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	4818	0.26
chr6_13434595_13434746	0.19	GFOD1	glucose-fructose oxidoreductase domain containing 1	26301	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0043368	positive T cell selection(GO:0043368)
0.1	0.5	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.4	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.3	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.3	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.3	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.4	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.7	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.5	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.4	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.4	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.2	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1	0.2	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1	0.3	GO:0070208	protein heterotrimerization(GO:0070208)
0.1	0.4	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.1	0.2	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.3	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	0.2	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1	0.2	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	0.2	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.2	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.1	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.1	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.1	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.1	0.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.1	0.2	GO:0006552	leucine catabolic process(GO:0006552)
0.1	0.2	GO:0010508	positive regulation of autophagy(GO:0010508)
0.1	0.1	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.2	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.1	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.2	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0046636	negative regulation of alpha-beta T cell activation(GO:0046636)
0.0	0.3	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0043330	response to exogenous dsRNA(GO:0043330)
0.0	0.2	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.3	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.2	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.2	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0046100	hypoxanthine metabolic process(GO:0046100)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.2	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0060027	convergent extension involved in gastrulation(GO:0060027)
0.0	0.2	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.2	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0	0.2	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.2	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.2	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.3	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0046349	amino sugar biosynthetic process(GO:0046349)
0.0	0.0	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.2	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.2	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.2	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.3	GO:0032459	regulation of protein oligomerization(GO:0032459)
0.0	0.1	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0060998	dendritic spine development(GO:0060996) regulation of dendritic spine development(GO:0060998)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.2	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.0	GO:0015919	peroxisomal membrane transport(GO:0015919)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0009125	nucleoside monophosphate catabolic process(GO:0009125)
0.0	0.1	GO:0031935	regulation of chromatin silencing(GO:0031935)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0021554	optic nerve development(GO:0021554)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.2	GO:0034285	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.1	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0021756	striatum development(GO:0021756)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.2	GO:0050974	detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0	0.1	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0060179	male courtship behavior(GO:0008049) male mating behavior(GO:0060179)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.2	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.0	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:0071504	cellular response to heparin(GO:0071504)
0.0	0.1	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.2	GO:0035964	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.1	GO:0015853	adenine transport(GO:0015853)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0002674	negative regulation of acute inflammatory response(GO:0002674)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0009261	ribonucleotide catabolic process(GO:0009261)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0061640	cytoskeleton-dependent cytokinesis(GO:0061640)
0.0	0.0	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:0046037	GMP metabolic process(GO:0046037)
0.0	0.1	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0006356	regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0	0.1	GO:0032613	interleukin-10 production(GO:0032613)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.2	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0051323	metaphase(GO:0051323)
0.0	0.1	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.2	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0021591	ventricular system development(GO:0021591)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0044273	sulfur compound catabolic process(GO:0044273)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.1	GO:0060423	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0	0.1	GO:0070245	positive regulation of lymphocyte apoptotic process(GO:0070230) positive regulation of T cell apoptotic process(GO:0070234) positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.1	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.1	GO:0019374	galactolipid metabolic process(GO:0019374)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.6	GO:0050688	regulation of defense response to virus(GO:0050688)
0.0	0.0	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.2	GO:0010171	body morphogenesis(GO:0010171)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.0	0.0	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.0	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0060324	face development(GO:0060324)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.2	GO:0048199	vesicle targeting, to, from or within Golgi(GO:0048199)
0.0	0.2	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.0	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.4	GO:0043044	ATP-dependent chromatin remodeling(GO:0043044)
0.0	0.1	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.3	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.0	GO:0009218	pyrimidine ribonucleotide metabolic process(GO:0009218) pyrimidine ribonucleotide biosynthetic process(GO:0009220)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0052646	alditol phosphate metabolic process(GO:0052646)
0.0	0.0	GO:0051154	negative regulation of striated muscle cell differentiation(GO:0051154)
0.0	0.1	GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process(GO:0009148)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0090103	cochlea morphogenesis(GO:0090103)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0090398	cellular senescence(GO:0090398)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.0	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.0	GO:0021794	thalamus development(GO:0021794)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.0	GO:0060453	regulation of gastric acid secretion(GO:0060453)
0.0	0.1	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0055070	copper ion homeostasis(GO:0055070)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.1	GO:1901881	positive regulation of protein depolymerization(GO:1901881)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.1	GO:0071230	cellular response to amino acid stimulus(GO:0071230)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.2	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.1	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0014010	Schwann cell proliferation(GO:0014010)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0045879	negative regulation of smoothened signaling pathway(GO:0045879)
0.0	0.0	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.0	0.0	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.0	GO:0090026	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.0	GO:0090281	negative regulation of calcium ion import(GO:0090281)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0006726	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.0	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.0	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0046131	pyrimidine ribonucleoside metabolic process(GO:0046131)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.2	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.4	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.0	0.1	GO:0010506	regulation of autophagy(GO:0010506)
0.0	0.0	GO:0035751	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.5	GO:0031124	mRNA 3'-end processing(GO:0031124)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.0	GO:0006998	nuclear envelope organization(GO:0006998)
0.0	0.0	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.0	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0010390	histone monoubiquitination(GO:0010390)
0.0	0.0	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.0	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:1903901	negative regulation of viral process(GO:0048525) negative regulation of viral life cycle(GO:1903901)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.0	GO:0010873	positive regulation of cholesterol esterification(GO:0010873)
0.0	0.0	GO:0045714	low-density lipoprotein particle receptor biosynthetic process(GO:0045713) regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0	0.0	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.0	GO:0072678	T cell migration(GO:0072678)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.0	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.3	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.1	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:0046218	tryptophan metabolic process(GO:0006568) tryptophan catabolic process(GO:0006569) indolalkylamine metabolic process(GO:0006586) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.0	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.1	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.3	GO:0043928	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.0	0.2	GO:0007098	centrosome cycle(GO:0007098)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0021692	cerebellar Purkinje cell layer morphogenesis(GO:0021692) cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.1	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0051225	spindle assembly(GO:0051225)
0.0	0.5	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.0	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.0	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:0032747	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.3	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0071438	invadopodium membrane(GO:0071438)
0.1	0.2	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	0.2	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.2	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.3	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.5	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.2	GO:0016589	NURF complex(GO:0016589)
0.0	0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.3	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.4	GO:0008278	cohesin complex(GO:0008278)
0.0	0.4	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.2	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.3	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.0	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0070938	contractile ring(GO:0070938)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.0	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0045120	pronucleus(GO:0045120)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.2	GO:0016235	aggresome(GO:0016235)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	0.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.0	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267)
0.0	0.5	GO:0015934	large ribosomal subunit(GO:0015934)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.4	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.2	GO:0000299	obsolete integral to membrane of membrane fraction(GO:0000299)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.4	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.3	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.5	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0035198	miRNA binding(GO:0035198)
0.1	0.3	GO:0031491	nucleosome binding(GO:0031491)
0.1	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.2	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.1	0.3	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.1	0.2	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1	0.2	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1	0.2	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0070402	NADPH binding(GO:0070402)
0.0	0.2	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.4	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.5	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.5	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.2	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.8	GO:0003823	antigen binding(GO:0003823)
0.0	0.2	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	1.3	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.3	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.5	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.0	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.5	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.2	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.3	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.0	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.0	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.3	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.0	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.3	GO:0016251	obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.5	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.5	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.0	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.2	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0008967	phosphoglycolate phosphatase activity(GO:0008967)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	1.7	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	0.0	GO:0004549	tRNA-specific ribonuclease activity(GO:0004549)
0.0	0.2	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.0	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.0	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0005109	frizzled binding(GO:0005109)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0005537	mannose binding(GO:0005537)
0.0	0.2	GO:0016836	hydro-lyase activity(GO:0016836)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
2.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.3	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	PID MYC PATHWAY	C-MYC pathway
0.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	ST STAT3 PATHWAY	STAT3 Pathway
0.2	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.1	PID BCR 5PATHWAY	BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	0.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.4	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.0	0.3	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.5	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.5	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.4	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.0	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.3	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.1	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	0.0	REACTOME ORC1 REMOVAL FROM CHROMATIN	Genes involved in Orc1 removal from chromatin
0.0	0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.6	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.5	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.1	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.0	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.3	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.2	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.1	REACTOME SIGNALING BY WNT	Genes involved in Signaling by Wnt
0.0	0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.1	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.5	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation

Results for NKX2-8

Z-value: 1.62

Motif logo

Transcription factors associated with NKX2-8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the NKX2-8 motif across conditions

Conditions sorted by the z-value of the NKX2-8 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: