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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX3-1

Z-value: 0.66

Motif logo

Transcription factors associated with NKX3-1

Gene Symbol	Gene ID	Gene Info
NKX3-1 Ensembl NCBI GeneCards UniProt	ENSG00000167034.9	NKX3-1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX3-1	chr8_23510263_23510414	30064	0.135650	-0.58	9.9e-02	Click!
NKX3-1	chr8_23540502_23540896	259	0.909043	0.48	1.9e-01	Click!
NKX3-1	chr8_23539616_23540460	364	0.854562	-0.15	7.0e-01	Click!

Activity of the NKX3-1 motif across conditions

Conditions sorted by the z-value of the NKX3-1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_24831599_24831750	0.50	RCAN3	RCAN family member 3	2287	0.27
chr17_33864237_33864745	0.44	SLFN12L	schlafen family member 12-like	389	0.76
chr1_160615359_160615600	0.36	SLAMF1	signaling lymphocytic activation molecule family member 1	1332	0.39
chr7_150148744_150149359	0.35	GIMAP8	GTPase, IMAP family member 8	1333	0.41
chr14_22999291_22999566	0.35	TRAJ15	T cell receptor alpha joining 15	848	0.46
chr13_97875674_97876020	0.30	MBNL2	muscleblind-like splicing regulator 2	1238	0.62
chr7_150413706_150414064	0.30	GIMAP1	GTPase, IMAP family member 1	240	0.91
chr1_226921433_226921633	0.30	ITPKB	inositol-trisphosphate 3-kinase B	3626	0.29
chr15_38854880_38855238	0.30	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	1777	0.36
chr14_22987346_22987542	0.29	TRAJ15	T cell receptor alpha joining 15	11136	0.1
chr12_40010191_40010342	0.29	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	3287	0.3
chr4_109086470_109087224	0.29	LEF1	lymphoid enhancer-binding factor 1	610	0.72
chr20_57721382_57721625	0.29	ZNF831	zinc finger protein 831	44572	0.15
chr13_24541098_24541249	0.28	SPATA13	spermatogenesis associated 13	12771	0.19
chr13_50657780_50657986	0.28	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	1576	0.37
chr14_102291594_102292005	0.28	CTD-2017C7.1		14069	0.14
chr5_58333022_58333173	0.28	PDE4D	phosphodiesterase 4D, cAMP-specific	2242	0.33
chr14_53593743_53594005	0.27	DDHD1	DDHD domain containing 1	22930	0.17
chr6_160940752_160940978	0.27	LPAL2	lipoprotein, Lp(a)-like 2, pseudogene	8826	0.3
chr5_54357840_54358274	0.27	ENSG00000240535	.	19385	0.12
chr14_22982783_22983297	0.27	TRAJ15	T cell receptor alpha joining 15	15540	0.1
chr2_86081133_86081567	0.27	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	13427	0.17
chr3_18477317_18477468	0.26	SATB1	SATB homeobox 1	647	0.74
chr1_156785806_156786457	0.26	SH2D2A	SH2 domain containing 2A	495	0.51
chr2_214004488_214004639	0.26	IKZF2	IKAROS family zinc finger 2 (Helios)	8790	0.3
chr8_128808074_128808411	0.26	ENSG00000249859	.	34	0.99
chr1_84612029_84612357	0.26	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	2239	0.42
chrY_7143368_7143656	0.26	PRKY	protein kinase, Y-linked, pseudogene	1158	0.57
chr6_156717396_156717547	0.26	ENSG00000212295	.	17587	0.3
chr4_153459156_153459307	0.26	ENSG00000268471	.	1651	0.34
chr12_6736731_6736882	0.25	LPAR5	lysophosphatidic acid receptor 5	4009	0.1
chr3_111261912_111262220	0.25	CD96	CD96 molecule	1069	0.62
chr1_100889106_100889257	0.25	ENSG00000216067	.	44850	0.13
chr2_204801338_204802214	0.25	ICOS	inducible T-cell co-stimulator	273	0.95
chr3_188115136_188115434	0.25	LPP	LIM domain containing preferred translocation partner in lipoma	157633	0.04
chr10_30993847_30994006	0.25	SVILP1	supervillin pseudogene 1	9076	0.27
chr11_128388558_128388952	0.25	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	3341	0.29
chr14_69248337_69248488	0.24	ZFP36L1	ZFP36 ring finger protein-like 1	9548	0.22
chr5_67577677_67577828	0.24	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1617	0.52
chr9_130736775_130737070	0.24	FAM102A	family with sequence similarity 102, member A	5870	0.12
chr13_95874473_95874624	0.24	ENSG00000238463	.	11950	0.25
chr13_99216323_99216474	0.24	STK24	serine/threonine kinase 24	12719	0.21
chr14_22977741_22978031	0.24	TRAJ15	T cell receptor alpha joining 15	20694	0.09
chr1_43422633_43422983	0.24	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	1692	0.36
chr1_160616059_160616370	0.24	SLAMF1	signaling lymphocytic activation molecule family member 1	597	0.7
chr6_109801750_109801916	0.24	ZBTB24	zinc finger and BTB domain containing 24	2607	0.17
chr12_14924776_14925101	0.23	HIST4H4	histone cluster 4, H4	873	0.43
chr19_17517338_17517489	0.23	MVB12A	multivesicular body subunit 12A	459	0.54
chr7_50267269_50267784	0.23	IKZF1	IKAROS family zinc finger 1 (Ikaros)	76798	0.1
chr6_106548995_106549243	0.23	RP1-134E15.3		1104	0.52
chr7_45068352_45068655	0.23	CCM2	cerebral cavernous malformation 2	1232	0.4
chr7_38389357_38389573	0.23	AMPH	amphiphysin	113248	0.07
chr1_84610970_84611403	0.23	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1232	0.6
chr11_128388975_128389288	0.23	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	2965	0.31
chr1_110046634_110046785	0.22	AMIGO1	adhesion molecule with Ig-like domain 1	5595	0.11
chr6_159234769_159235011	0.22	EZR-AS1	EZR antisense RNA 1	4153	0.2
chr2_214010651_214010802	0.22	IKZF2	IKAROS family zinc finger 2 (Helios)	2627	0.41
chr2_68962051_68962936	0.22	ARHGAP25	Rho GTPase activating protein 25	479	0.86
chr14_61799079_61799314	0.22	PRKCH	protein kinase C, eta	5565	0.21
chr2_198756913_198757256	0.22	PLCL1	phospholipase C-like 1	82102	0.1
chrX_78343760_78343985	0.22	GPR174	G protein-coupled receptor 174	82597	0.11
chr1_112167264_112167415	0.21	RAP1A	RAP1A, member of RAS oncogene family	4570	0.2
chr5_156621256_156621554	0.21	ITK	IL2-inducible T-cell kinase	13568	0.12
chr21_33033050_33033234	0.21	SOD1	superoxide dismutase 1, soluble	1163	0.44
chr1_179801278_179801429	0.21	RP11-12M5.3		14027	0.16
chr7_8011713_8012079	0.21	AC006042.7		2362	0.25
chr22_24796948_24797099	0.21	ADORA2A	adenosine A2a receptor	22542	0.18
chr10_18790313_18790509	0.21	RP11-383B4.4		31854	0.18
chr14_22948364_22948515	0.21	ENSG00000251002	.	1839	0.18
chr1_89737700_89738180	0.21	GBP5	guanylate binding protein 5	547	0.77
chr3_34525180_34525331	0.21	PDCD6IP	programmed cell death 6 interacting protein	685140	0.0
chr9_123885039_123885250	0.21	CNTRL	centriolin	1065	0.57
chr17_40424104_40424391	0.21	AC003104.1		454	0.71
chrX_40033281_40033432	0.21	BCOR	BCL6 corepressor	3217	0.38
chr17_38019970_38020260	0.21	IKZF3	IKAROS family zinc finger 3 (Aiolos)	264	0.89
chr6_106550239_106550540	0.20	RP1-134E15.3		2374	0.32
chr6_143248743_143249008	0.20	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	17463	0.25
chr11_76794049_76794313	0.20	CAPN5	calpain 5	16141	0.16
chr19_16471836_16472011	0.20	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	841	0.55
chr2_143934651_143934928	0.20	RP11-190J23.1		5048	0.3
chr15_81585953_81586104	0.20	IL16	interleukin 16	3226	0.26
chr2_38826300_38826455	0.20	HNRNPLL	heterogeneous nuclear ribonucleoprotein L-like	791	0.61
chr4_154360305_154360456	0.20	KIAA0922	KIAA0922	27118	0.19
chr2_127783302_127783743	0.20	ENSG00000238788	.	8525	0.27
chr1_101784802_101784953	0.20	RP4-575N6.5		76163	0.09
chr13_42033808_42033959	0.20	RGCC	regulator of cell cycle	2188	0.25
chr2_143888975_143889165	0.20	ARHGAP15	Rho GTPase activating protein 15	2187	0.4
chr18_33550373_33550669	0.20	C18orf21	chromosome 18 open reading frame 21	1525	0.4
chr6_35267244_35267414	0.20	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1700	0.35
chr21_43345808_43345959	0.19	C2CD2	C2 calcium-dependent domain containing 2	916	0.55
chr15_45007683_45007937	0.19	B2M	beta-2-microglobulin	4095	0.17
chr20_57426029_57426307	0.19	GNAS-AS1	GNAS antisense RNA 1	210	0.89
chr2_235399576_235400049	0.19	ARL4C	ADP-ribosylation factor-like 4C	5432	0.35
chr12_45268809_45268960	0.19	NELL2	NEL-like 2 (chicken)	367	0.9
chr13_30950896_30951047	0.19	KATNAL1	katanin p60 subunit A-like 1	69350	0.11
chr11_73692681_73692970	0.19	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	842	0.53
chr12_121570606_121571339	0.19	P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	198	0.94
chr12_9767730_9767881	0.19	KLRB1	killer cell lectin-like receptor subfamily B, member 1	7323	0.14
chr18_48492673_48492824	0.19	ELAC1	elaC ribonuclease Z 1	1613	0.3
chr12_9760266_9760417	0.19	KLRB1	killer cell lectin-like receptor subfamily B, member 1	141	0.94
chr19_23945488_23945685	0.19	RPSAP58	ribosomal protein SA pseudogene 58	221	0.93
chr4_38511777_38511989	0.19	RP11-617D20.1		114313	0.06
chrY_7542080_7542231	0.19	RFTN1P1	raftlin, lipid raft linker 1 pseudogene 1	102593	0.08
chr18_21572812_21573447	0.19	TTC39C	tetratricopeptide repeat domain 39C	392	0.85
chr8_23312978_23313222	0.19	ENTPD4	ectonucleoside triphosphate diphosphohydrolase 4	2060	0.32
chr4_143321559_143321710	0.19	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30778	0.27
chr6_149816889_149817128	0.19	ZC3H12D	zinc finger CCCH-type containing 12D	10811	0.15
chrX_71003919_71004210	0.18	ENSG00000221684	.	24759	0.22
chr10_130834757_130834924	0.18	MGMT	O-6-methylguanine-DNA methyltransferase	430608	0.01
chrX_70917042_70917365	0.18	ENSG00000221684	.	62102	0.11
chr19_40169930_40170081	0.18	LGALS17A		9	0.96
chr6_154570961_154571273	0.18	IPCEF1	interaction protein for cytohesin exchange factors 1	2301	0.45
chr15_56537627_56537839	0.18	TEX9	testis expressed 9	1526	0.37
chr13_99216166_99216317	0.18	STK24	serine/threonine kinase 24	12876	0.21
chr2_214010385_214010590	0.18	IKZF2	IKAROS family zinc finger 2 (Helios)	2866	0.4
chr16_81748402_81748687	0.18	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	24158	0.24
chr2_175708437_175708594	0.18	CHN1	chimerin 1	2618	0.35
chr9_273119_273416	0.18	DOCK8	dedicator of cytokinesis 8	197	0.59
chr17_2699734_2700214	0.18	RAP1GAP2	RAP1 GTPase activating protein 2	198	0.94
chr12_104888025_104888586	0.18	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	37526	0.2
chr6_112083181_112083332	0.18	FYN	FYN oncogene related to SRC, FGR, YES	2136	0.42
chr10_6626003_6626633	0.18	PRKCQ	protein kinase C, theta	4055	0.36
chrY_23417410_23417561	0.17	CYorf17	chromosome Y open reading frame 17	130761	0.05
chr6_117869427_117870101	0.17	GOPC	golgi-associated PDZ and coiled-coil motif containing	53763	0.12
chr13_75900551_75900966	0.17	TBC1D4	TBC1 domain family, member 4	14909	0.24
chrX_13680096_13680380	0.17	TCEANC	transcription elongation factor A (SII) N-terminal and central domain containing	6824	0.2
chr4_154419256_154419548	0.17	KIAA0922	KIAA0922	31901	0.2
chr7_150147681_150147832	0.17	GIMAP8	GTPase, IMAP family member 8	38	0.97
chr14_60650630_60650881	0.17	DHRS7	dehydrogenase/reductase (SDR family) member 7	14181	0.21
chr2_23755902_23756169	0.17	AC011239.1	Uncharacterized protein	8821	0.3
chr14_65880630_65880947	0.17	FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	1048	0.63
chr7_150417044_150417195	0.17	GIMAP1	GTPase, IMAP family member 1	3474	0.2
chr6_24926936_24927087	0.17	FAM65B	family with sequence similarity 65, member B	9177	0.23
chr14_99733165_99733625	0.17	AL109767.1		4110	0.24
chr4_70625874_70626025	0.17	SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	367	0.91
chr11_60744031_60744182	0.17	CD6	CD6 molecule	4768	0.13
chr8_8727017_8727210	0.17	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	24042	0.18
chr17_28049935_28050167	0.17	RP11-82O19.1		38070	0.1
chr3_13057259_13057549	0.17	IQSEC1	IQ motif and Sec7 domain 1	28868	0.23
chr20_45983472_45983818	0.17	ZMYND8	zinc finger, MYND-type containing 8	756	0.54
chr6_143164322_143164558	0.17	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	6256	0.3
chr2_197030684_197030835	0.17	STK17B	serine/threonine kinase 17b	4965	0.22
chr14_106326931_106327329	0.17	ENSG00000265714	.	1106	0.09
chr4_26885727_26885945	0.17	STIM2	stromal interaction molecule 2	22755	0.22
chr6_170920732_170921165	0.17	PDCD2	programmed cell death 2	27200	0.19
chr4_154388914_154389185	0.17	KIAA0922	KIAA0922	1548	0.49
chr11_64636867_64637025	0.17	EHD1	EH-domain containing 1	6192	0.1
chr6_118880020_118880242	0.17	PLN	phospholamban	10670	0.3
chr2_162915924_162916075	0.17	AC008063.2		13767	0.2
chr8_71564383_71564535	0.17	ENSG00000243532	.	2659	0.21
chr6_106547367_106547905	0.17	RP1-134E15.3		379	0.74
chr2_191274324_191274475	0.17	MFSD6	major facilitator superfamily domain containing 6	1318	0.47
chr10_6110992_6111224	0.16	IL2RA	interleukin 2 receptor, alpha	6820	0.16
chr3_110345992_110346143	0.16	ENSG00000221206	.	75255	0.12
chr15_100345675_100345826	0.16	CTD-2054N24.2	Uncharacterized protein	1478	0.31
chr9_125799790_125799941	0.16	GPR21	G protein-coupled receptor 21	3059	0.22
chr10_61667108_61667259	0.16	CCDC6	coiled-coil domain containing 6	769	0.74
chr2_202127394_202127951	0.16	CASP8	caspase 8, apoptosis-related cysteine peptidase	993	0.56
chr4_40205321_40205527	0.16	RHOH	ras homolog family member H	3460	0.27
chr4_154388544_154388898	0.16	KIAA0922	KIAA0922	1220	0.57
chrX_118819066_118819466	0.16	SEPT6	septin 6	7526	0.18
chr16_17463239_17463649	0.16	XYLT1	xylosyltransferase I	101294	0.09
chr7_26193443_26193677	0.16	NFE2L3	nuclear factor, erythroid 2-like 3	1700	0.36
chr4_122164507_122165136	0.16	TNIP3	TNFAIP3 interacting protein 3	16200	0.22
chr10_32665664_32666047	0.16	EPC1	enhancer of polycomb homolog 1 (Drosophila)	1871	0.27
chr12_104854827_104855220	0.16	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	4244	0.32
chr11_70211468_70211619	0.16	AP000487.6		2069	0.21
chr2_192540821_192541028	0.16	NABP1	nucleic acid binding protein 1	1938	0.47
chr1_160611300_160611550	0.16	SLAMF1	signaling lymphocytic activation molecule family member 1	5386	0.18
chr15_65187513_65187769	0.16	ENSG00000264929	.	4797	0.17
chr3_56788528_56788714	0.16	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	20974	0.24
chr4_4765123_4765274	0.16	MSX1	msh homeobox 1	96195	0.08
chr6_161351612_161351773	0.16	RP3-428L16.1		420	0.89
chr6_149415675_149415826	0.16	RP11-162J8.3		62041	0.12
chr2_62702174_62702386	0.16	ENSG00000241625	.	16033	0.23
chr10_75011688_75012124	0.16	MRPS16	mitochondrial ribosomal protein S16	484	0.47
chr10_70360809_70361174	0.16	TET1	tet methylcytosine dioxygenase 1	40578	0.13
chr7_50355345_50355813	0.16	IKZF1	IKAROS family zinc finger 1 (Ikaros)	7261	0.3
chr22_44577376_44577610	0.16	PARVG	parvin, gamma	215	0.96
chrX_123482778_123482929	0.15	SH2D1A	SH2 domain containing 1A	2414	0.44
chr1_226922484_226922931	0.15	ITPKB	inositol-trisphosphate 3-kinase B	2452	0.34
chr14_92339571_92339902	0.15	FBLN5	fibulin 5	4650	0.23
chr4_109080254_109080405	0.15	LEF1	lymphoid enhancer-binding factor 1	7128	0.24
chr4_96645430_96645581	0.15	PDHA2	pyruvate dehydrogenase (lipoamide) alpha 2	115734	0.06
chr6_170403243_170403627	0.15	RP11-302L19.1		74306	0.11
chr18_66440168_66440319	0.15	RP11-106E15.1		18423	0.2
chr5_55315108_55315259	0.15	ENSG00000238326	.	18734	0.15
chr13_42849044_42849223	0.15	AKAP11	A kinase (PRKA) anchor protein 11	2844	0.38
chr14_91488738_91489174	0.15	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	37522	0.15
chr19_55766409_55766580	0.15	PPP6R1	protein phosphatase 6, regulatory subunit 1	643	0.49
chr19_42432968_42433149	0.15	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	5812	0.14
chr5_1800151_1800360	0.15	MRPL36	mitochondrial ribosomal protein L36	246	0.88
chr3_186745964_186746115	0.15	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	2768	0.33
chr4_78738053_78738204	0.15	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	2089	0.42
chr8_10981801_10982129	0.15	AF131215.3		1609	0.27
chr11_128380502_128380688	0.15	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	5306	0.26
chr13_75900993_75901212	0.15	TBC1D4	TBC1 domain family, member 4	14565	0.24
chr2_143898305_143898456	0.15	ARHGAP15	Rho GTPase activating protein 15	11497	0.25
chr20_33999186_33999337	0.15	UQCC1	ubiquinol-cytochrome c reductase complex assembly factor 1	505	0.71
chr15_22547843_22548176	0.15	ENSG00000221641	.	34729	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.1	0.4	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.2	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.2	GO:0071025	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.2	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.3	GO:0009812	flavonoid metabolic process(GO:0009812)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.1	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.3	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0002420	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0002839	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.3	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.7	GO:0006997	nucleus organization(GO:0006997)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.2	GO:0000303	response to superoxide(GO:0000303)
0.0	0.2	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.1	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.0	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0031935	regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0006301	postreplication repair(GO:0006301)
0.0	0.0	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.1	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0006743	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0034390	smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.9	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.2	GO:0032011	ARF protein signal transduction(GO:0032011)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.0	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0098534	centriole replication(GO:0007099) centriole assembly(GO:0098534)
0.0	0.0	GO:0031507	heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0010833	telomere maintenance via telomere lengthening(GO:0010833)
0.0	0.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.0	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.0	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.0	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.0	GO:0000002	mitochondrial genome maintenance(GO:0000002)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.0	GO:0021819	cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0006103	2-oxoglutarate metabolic process(GO:0006103)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0045954	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.3	GO:0000724	double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.2	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.0	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0070076	histone lysine demethylation(GO:0070076)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.2	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.0	GO:0032469	endoplasmic reticulum calcium ion homeostasis(GO:0032469)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.2	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.3	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.3	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.6	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.3	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.3	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.2	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.0	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	1.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.0	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.5	GO:0003823	antigen binding(GO:0003823)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.1	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.0	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.0	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.3	GO:0001614	purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0	0.1	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.8	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.2	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.1	GO:1901677	organophosphate ester transmembrane transporter activity(GO:0015605) phosphate transmembrane transporter activity(GO:1901677)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.0	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.2	GO:0016409	palmitoyltransferase activity(GO:0016409)
0.0	0.0	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
1.5	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.2	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.5	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	0.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	1.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.3	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.0	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	1.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.2	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.0	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling