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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for NKX3-1

Z-value: 0.66

Motif logo

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Transcription factors associated with NKX3-1

Gene Symbol Gene ID Gene Info
NKX3-1
ENSG00000167034.9 NK3 homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr8_23510263_23510414NKX3-1300640.135650-0.589.9e-02Click!
chr8_23540502_23540896NKX3-12590.9090430.481.9e-01Click!
chr8_23539616_23540460NKX3-13640.854562-0.157.0e-01Click!

Activity of the NKX3-1 motif across conditions

Conditions sorted by the z-value of the NKX3-1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_24831599_24831750 0.50 RCAN3
 RCAN family member 3
 2287
 0.27
chr17_33864237_33864745 0.44 SLFN12L
 schlafen family member 12-like
 389
 0.76
chr1_160615359_160615600 0.36 SLAMF1
 signaling lymphocytic activation molecule family member 1
 1332
 0.39
chr7_150148744_150149359 0.35 GIMAP8
 GTPase, IMAP family member 8
 1333
 0.41
chr14_22999291_22999566 0.35 TRAJ15
 T cell receptor alpha joining 15
 848
 0.46
chr13_97875674_97876020 0.30 MBNL2
 muscleblind-like splicing regulator 2
 1238
 0.62
chr7_150413706_150414064 0.30 GIMAP1
 GTPase, IMAP family member 1
 240
 0.91
chr1_226921433_226921633 0.30 ITPKB
 inositol-trisphosphate 3-kinase B
 3626
 0.29
chr15_38854880_38855238 0.30 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 1777
 0.36
chr14_22987346_22987542 0.29 TRAJ15
 T cell receptor alpha joining 15
 11136
 0.1
chr12_40010191_40010342 0.29 ABCD2
 ATP-binding cassette, sub-family D (ALD), member 2
 3287
 0.3
chr4_109086470_109087224 0.29 LEF1
 lymphoid enhancer-binding factor 1
 610
 0.72
chr20_57721382_57721625 0.29 ZNF831
 zinc finger protein 831
 44572
 0.15
chr13_24541098_24541249 0.28 SPATA13
 spermatogenesis associated 13
 12771
 0.19
chr13_50657780_50657986 0.28 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 1576
 0.37
chr14_102291594_102292005 0.28 CTD-2017C7.1
14069
 0.14
chr5_58333022_58333173 0.28 PDE4D
 phosphodiesterase 4D, cAMP-specific
 2242
 0.33
chr14_53593743_53594005 0.27 DDHD1
 DDHD domain containing 1
 22930
 0.17
chr6_160940752_160940978 0.27 LPAL2
 lipoprotein, Lp(a)-like 2, pseudogene
 8826
 0.3
chr5_54357840_54358274 0.27 ENSG00000240535
 .
 19385
 0.12
chr14_22982783_22983297 0.27 TRAJ15
 T cell receptor alpha joining 15
 15540
 0.1
chr2_86081133_86081567 0.27 ST3GAL5
 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
 13427
 0.17
chr3_18477317_18477468 0.26 SATB1
 SATB homeobox 1
 647
 0.74
chr1_156785806_156786457 0.26 SH2D2A
 SH2 domain containing 2A
 495
 0.51
chr2_214004488_214004639 0.26 IKZF2
 IKAROS family zinc finger 2 (Helios)
 8790
 0.3
chr8_128808074_128808411 0.26 ENSG00000249859
 .
 34
 0.99
chr1_84612029_84612357 0.26 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 2239
 0.42
chrY_7143368_7143656 0.26 PRKY
 protein kinase, Y-linked, pseudogene
 1158
 0.57
chr6_156717396_156717547 0.26 ENSG00000212295
 .
 17587
 0.3
chr4_153459156_153459307 0.26 ENSG00000268471
 .
 1651
 0.34
chr12_6736731_6736882 0.25 LPAR5
 lysophosphatidic acid receptor 5
 4009
 0.1
chr3_111261912_111262220 0.25 CD96
 CD96 molecule
 1069
 0.62
chr1_100889106_100889257 0.25 ENSG00000216067
 .
 44850
 0.13
chr2_204801338_204802214 0.25 ICOS
 inducible T-cell co-stimulator
 273
 0.95
chr3_188115136_188115434 0.25 LPP
 LIM domain containing preferred translocation partner in lipoma
 157633
 0.04
chr10_30993847_30994006 0.25 SVILP1
 supervillin pseudogene 1
 9076
 0.27
chr11_128388558_128388952 0.25 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 3341
 0.29
chr14_69248337_69248488 0.24 ZFP36L1
 ZFP36 ring finger protein-like 1
 9548
 0.22
chr5_67577677_67577828 0.24 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 1617
 0.52
chr9_130736775_130737070 0.24 FAM102A
 family with sequence similarity 102, member A
 5870
 0.12
chr13_95874473_95874624 0.24 ENSG00000238463
 .
 11950
 0.25
chr13_99216323_99216474 0.24 STK24
 serine/threonine kinase 24
 12719
 0.21
chr14_22977741_22978031 0.24 TRAJ15
 T cell receptor alpha joining 15
 20694
 0.09
chr1_43422633_43422983 0.24 SLC2A1
 solute carrier family 2 (facilitated glucose transporter), member 1
 1692
 0.36
chr1_160616059_160616370 0.24 SLAMF1
 signaling lymphocytic activation molecule family member 1
 597
 0.7
chr6_109801750_109801916 0.24 ZBTB24
 zinc finger and BTB domain containing 24
 2607
 0.17
chr12_14924776_14925101 0.23 HIST4H4
 histone cluster 4, H4
 873
 0.43
chr19_17517338_17517489 0.23 MVB12A
 multivesicular body subunit 12A
 459
 0.54
chr7_50267269_50267784 0.23 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 76798
 0.1
chr6_106548995_106549243 0.23 RP1-134E15.3
1104
 0.52
chr7_45068352_45068655 0.23 CCM2
 cerebral cavernous malformation 2
 1232
 0.4
chr7_38389357_38389573 0.23 AMPH
 amphiphysin
 113248
 0.07
chr1_84610970_84611403 0.23 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 1232
 0.6
chr11_128388975_128389288 0.23 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 2965
 0.31
chr1_110046634_110046785 0.22 AMIGO1
 adhesion molecule with Ig-like domain 1
 5595
 0.11
chr6_159234769_159235011 0.22 EZR-AS1
 EZR antisense RNA 1
 4153
 0.2
chr2_214010651_214010802 0.22 IKZF2
 IKAROS family zinc finger 2 (Helios)
 2627
 0.41
chr2_68962051_68962936 0.22 ARHGAP25
 Rho GTPase activating protein 25
 479
 0.86
chr14_61799079_61799314 0.22 PRKCH
 protein kinase C, eta
 5565
 0.21
chr2_198756913_198757256 0.22 PLCL1
 phospholipase C-like 1
 82102
 0.1
chrX_78343760_78343985 0.22 GPR174
 G protein-coupled receptor 174
 82597
 0.11
chr1_112167264_112167415 0.21 RAP1A
 RAP1A, member of RAS oncogene family
 4570
 0.2
chr5_156621256_156621554 0.21 ITK
 IL2-inducible T-cell kinase
 13568
 0.12
chr21_33033050_33033234 0.21 SOD1
 superoxide dismutase 1, soluble
 1163
 0.44
chr1_179801278_179801429 0.21 RP11-12M5.3
14027
 0.16
chr7_8011713_8012079 0.21 AC006042.7
2362
 0.25
chr22_24796948_24797099 0.21 ADORA2A
 adenosine A2a receptor
 22542
 0.18
chr10_18790313_18790509 0.21 RP11-383B4.4
31854
 0.18
chr14_22948364_22948515 0.21 ENSG00000251002
 .
 1839
 0.18
chr1_89737700_89738180 0.21 GBP5
 guanylate binding protein 5
 547
 0.77
chr3_34525180_34525331 0.21 PDCD6IP
 programmed cell death 6 interacting protein
 685140
 0.0
chr9_123885039_123885250 0.21 CNTRL
 centriolin
 1065
 0.57
chr17_40424104_40424391 0.21 AC003104.1
454
 0.71
chrX_40033281_40033432 0.21 BCOR
 BCL6 corepressor
 3217
 0.38
chr17_38019970_38020260 0.21 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 264
 0.89
chr6_106550239_106550540 0.20 RP1-134E15.3
2374
 0.32
chr6_143248743_143249008 0.20 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 17463
 0.25
chr11_76794049_76794313 0.20 CAPN5
 calpain 5
 16141
 0.16
chr19_16471836_16472011 0.20 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 841
 0.55
chr2_143934651_143934928 0.20 RP11-190J23.1
5048
 0.3
chr15_81585953_81586104 0.20 IL16
 interleukin 16
 3226
 0.26
chr2_38826300_38826455 0.20 HNRNPLL
 heterogeneous nuclear ribonucleoprotein L-like
 791
 0.61
chr4_154360305_154360456 0.20 KIAA0922
 KIAA0922
 27118
 0.19
chr2_127783302_127783743 0.20 ENSG00000238788
 .
 8525
 0.27
chr1_101784802_101784953 0.20 RP4-575N6.5
76163
 0.09
chr13_42033808_42033959 0.20 RGCC
 regulator of cell cycle
 2188
 0.25
chr2_143888975_143889165 0.20 ARHGAP15
 Rho GTPase activating protein 15
 2187
 0.4
chr18_33550373_33550669 0.20 C18orf21
 chromosome 18 open reading frame 21
 1525
 0.4
chr6_35267244_35267414 0.20 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 1700
 0.35
chr21_43345808_43345959 0.19 C2CD2
 C2 calcium-dependent domain containing 2
 916
 0.55
chr15_45007683_45007937 0.19 B2M
 beta-2-microglobulin
 4095
 0.17
chr20_57426029_57426307 0.19 GNAS-AS1
 GNAS antisense RNA 1
 210
 0.89
chr2_235399576_235400049 0.19 ARL4C
 ADP-ribosylation factor-like 4C
 5432
 0.35
chr12_45268809_45268960 0.19 NELL2
 NEL-like 2 (chicken)
 367
 0.9
chr13_30950896_30951047 0.19 KATNAL1
 katanin p60 subunit A-like 1
 69350
 0.11
chr11_73692681_73692970 0.19 UCP2
 uncoupling protein 2 (mitochondrial, proton carrier)
 842
 0.53
chr12_121570606_121571339 0.19 P2RX7
 purinergic receptor P2X, ligand-gated ion channel, 7
 198
 0.94
chr12_9767730_9767881 0.19 KLRB1
 killer cell lectin-like receptor subfamily B, member 1
 7323
 0.14
chr18_48492673_48492824 0.19 ELAC1
 elaC ribonuclease Z 1
 1613
 0.3
chr12_9760266_9760417 0.19 KLRB1
 killer cell lectin-like receptor subfamily B, member 1
 141
 0.94
chr19_23945488_23945685 0.19 RPSAP58
 ribosomal protein SA pseudogene 58
 221
 0.93
chr4_38511777_38511989 0.19 RP11-617D20.1
114313
 0.06
chrY_7542080_7542231 0.19 RFTN1P1
 raftlin, lipid raft linker 1 pseudogene 1
 102593
 0.08
chr18_21572812_21573447 0.19 TTC39C
 tetratricopeptide repeat domain 39C
 392
 0.85
chr8_23312978_23313222 0.19 ENTPD4
 ectonucleoside triphosphate diphosphohydrolase 4
 2060
 0.32
chr4_143321559_143321710 0.19 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 30778
 0.27
chr6_149816889_149817128 0.19 ZC3H12D
 zinc finger CCCH-type containing 12D
 10811
 0.15
chrX_71003919_71004210 0.18 ENSG00000221684
 .
 24759
 0.22
chr10_130834757_130834924 0.18 MGMT
 O-6-methylguanine-DNA methyltransferase
 430608
 0.01
chrX_70917042_70917365 0.18 ENSG00000221684
 .
 62102
 0.11
chr19_40169930_40170081 0.18 LGALS17A
9
 0.96
chr6_154570961_154571273 0.18 IPCEF1
 interaction protein for cytohesin exchange factors 1
 2301
 0.45
chr15_56537627_56537839 0.18 TEX9
 testis expressed 9
 1526
 0.37
chr13_99216166_99216317 0.18 STK24
 serine/threonine kinase 24
 12876
 0.21
chr2_214010385_214010590 0.18 IKZF2
 IKAROS family zinc finger 2 (Helios)
 2866
 0.4
chr16_81748402_81748687 0.18 PLCG2
 phospholipase C, gamma 2 (phosphatidylinositol-specific)
 24158
 0.24
chr2_175708437_175708594 0.18 CHN1
 chimerin 1
 2618
 0.35
chr9_273119_273416 0.18 DOCK8
 dedicator of cytokinesis 8
 197
 0.59
chr17_2699734_2700214 0.18 RAP1GAP2
 RAP1 GTPase activating protein 2
 198
 0.94
chr12_104888025_104888586 0.18 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 37526
 0.2
chr6_112083181_112083332 0.18 FYN
 FYN oncogene related to SRC, FGR, YES
 2136
 0.42
chr10_6626003_6626633 0.18 PRKCQ
 protein kinase C, theta
 4055
 0.36
chrY_23417410_23417561 0.17 CYorf17
 chromosome Y open reading frame 17
 130761
 0.05
chr6_117869427_117870101 0.17 GOPC
 golgi-associated PDZ and coiled-coil motif containing
 53763
 0.12
chr13_75900551_75900966 0.17 TBC1D4
 TBC1 domain family, member 4
 14909
 0.24
chrX_13680096_13680380 0.17 TCEANC
 transcription elongation factor A (SII) N-terminal and central domain containing
 6824
 0.2
chr4_154419256_154419548 0.17 KIAA0922
 KIAA0922
 31901
 0.2
chr7_150147681_150147832 0.17 GIMAP8
 GTPase, IMAP family member 8
 38
 0.97
chr14_60650630_60650881 0.17 DHRS7
 dehydrogenase/reductase (SDR family) member 7
 14181
 0.21
chr2_23755902_23756169 0.17 AC011239.1
 Uncharacterized protein
 8821
 0.3
chr14_65880630_65880947 0.17 FUT8
 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
 1048
 0.63
chr7_150417044_150417195 0.17 GIMAP1
 GTPase, IMAP family member 1
 3474
 0.2
chr6_24926936_24927087 0.17 FAM65B
 family with sequence similarity 65, member B
 9177
 0.23
chr14_99733165_99733625 0.17 AL109767.1
4110
 0.24
chr4_70625874_70626025 0.17 SULT1B1
 sulfotransferase family, cytosolic, 1B, member 1
 367
 0.91
chr11_60744031_60744182 0.17 CD6
 CD6 molecule
 4768
 0.13
chr8_8727017_8727210 0.17 MFHAS1
 malignant fibrous histiocytoma amplified sequence 1
 24042
 0.18
chr17_28049935_28050167 0.17 RP11-82O19.1
38070
 0.1
chr3_13057259_13057549 0.17 IQSEC1
 IQ motif and Sec7 domain 1
 28868
 0.23
chr20_45983472_45983818 0.17 ZMYND8
 zinc finger, MYND-type containing 8
 756
 0.54
chr6_143164322_143164558 0.17 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 6256
 0.3
chr2_197030684_197030835 0.17 STK17B
 serine/threonine kinase 17b
 4965
 0.22
chr14_106326931_106327329 0.17 ENSG00000265714
 .
 1106
 0.09
chr4_26885727_26885945 0.17 STIM2
 stromal interaction molecule 2
 22755
 0.22
chr6_170920732_170921165 0.17 PDCD2
 programmed cell death 2
 27200
 0.19
chr4_154388914_154389185 0.17 KIAA0922
 KIAA0922
 1548
 0.49
chr11_64636867_64637025 0.17 EHD1
 EH-domain containing 1
 6192
 0.1
chr6_118880020_118880242 0.17 PLN
 phospholamban
 10670
 0.3
chr2_162915924_162916075 0.17 AC008063.2
13767
 0.2
chr8_71564383_71564535 0.17 ENSG00000243532
 .
 2659
 0.21
chr6_106547367_106547905 0.17 RP1-134E15.3
379
 0.74
chr2_191274324_191274475 0.17 MFSD6
 major facilitator superfamily domain containing 6
 1318
 0.47
chr10_6110992_6111224 0.16 IL2RA
 interleukin 2 receptor, alpha
 6820
 0.16
chr3_110345992_110346143 0.16 ENSG00000221206
 .
 75255
 0.12
chr15_100345675_100345826 0.16 CTD-2054N24.2
 Uncharacterized protein
 1478
 0.31
chr9_125799790_125799941 0.16 GPR21
 G protein-coupled receptor 21
 3059
 0.22
chr10_61667108_61667259 0.16 CCDC6
 coiled-coil domain containing 6
 769
 0.74
chr2_202127394_202127951 0.16 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 993
 0.56
chr4_40205321_40205527 0.16 RHOH
 ras homolog family member H
 3460
 0.27
chr4_154388544_154388898 0.16 KIAA0922
 KIAA0922
 1220
 0.57
chrX_118819066_118819466 0.16 SEPT6
 septin 6
 7526
 0.18
chr16_17463239_17463649 0.16 XYLT1
 xylosyltransferase I
 101294
 0.09
chr7_26193443_26193677 0.16 NFE2L3
 nuclear factor, erythroid 2-like 3
 1700
 0.36
chr4_122164507_122165136 0.16 TNIP3
 TNFAIP3 interacting protein 3
 16200
 0.22
chr10_32665664_32666047 0.16 EPC1
 enhancer of polycomb homolog 1 (Drosophila)
 1871
 0.27
chr12_104854827_104855220 0.16 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 4244
 0.32
chr11_70211468_70211619 0.16 AP000487.6
2069
 0.21
chr2_192540821_192541028 0.16 NABP1
 nucleic acid binding protein 1
 1938
 0.47
chr1_160611300_160611550 0.16 SLAMF1
 signaling lymphocytic activation molecule family member 1
 5386
 0.18
chr15_65187513_65187769 0.16 ENSG00000264929
 .
 4797
 0.17
chr3_56788528_56788714 0.16 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 20974
 0.24
chr4_4765123_4765274 0.16 MSX1
 msh homeobox 1
 96195
 0.08
chr6_161351612_161351773 0.16 RP3-428L16.1
420
 0.89
chr6_149415675_149415826 0.16 RP11-162J8.3
62041
 0.12
chr2_62702174_62702386 0.16 ENSG00000241625
 .
 16033
 0.23
chr10_75011688_75012124 0.16 MRPS16
 mitochondrial ribosomal protein S16
 484
 0.47
chr10_70360809_70361174 0.16 TET1
 tet methylcytosine dioxygenase 1
 40578
 0.13
chr7_50355345_50355813 0.16 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 7261
 0.3
chr22_44577376_44577610 0.16 PARVG
 parvin, gamma
 215
 0.96
chrX_123482778_123482929 0.15 SH2D1A
 SH2 domain containing 1A
 2414
 0.44
chr1_226922484_226922931 0.15 ITPKB
 inositol-trisphosphate 3-kinase B
 2452
 0.34
chr14_92339571_92339902 0.15 FBLN5
 fibulin 5
 4650
 0.23
chr4_109080254_109080405 0.15 LEF1
 lymphoid enhancer-binding factor 1
 7128
 0.24
chr4_96645430_96645581 0.15 PDHA2
 pyruvate dehydrogenase (lipoamide) alpha 2
 115734
 0.06
chr6_170403243_170403627 0.15 RP11-302L19.1
74306
 0.11
chr18_66440168_66440319 0.15 RP11-106E15.1
18423
 0.2
chr5_55315108_55315259 0.15 ENSG00000238326
 .
 18734
 0.15
chr13_42849044_42849223 0.15 AKAP11
 A kinase (PRKA) anchor protein 11
 2844
 0.38
chr14_91488738_91489174 0.15 RPS6KA5
 ribosomal protein S6 kinase, 90kDa, polypeptide 5
 37522
 0.15
chr19_55766409_55766580 0.15 PPP6R1
 protein phosphatase 6, regulatory subunit 1
 643
 0.49
chr19_42432968_42433149 0.15 ARHGEF1
 Rho guanine nucleotide exchange factor (GEF) 1
 5812
 0.14
chr5_1800151_1800360 0.15 MRPL36
 mitochondrial ribosomal protein L36
 246
 0.88
chr3_186745964_186746115 0.15 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 2768
 0.33
chr4_78738053_78738204 0.15 CNOT6L
 CCR4-NOT transcription complex, subunit 6-like
 2089
 0.42
chr8_10981801_10982129 0.15 AF131215.3
1609
 0.27
chr11_128380502_128380688 0.15 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 5306
 0.26
chr13_75900993_75901212 0.15 TBC1D4
 TBC1 domain family, member 4
 14565
 0.24
chr2_143898305_143898456 0.15 ARHGAP15
 Rho GTPase activating protein 15
 11497
 0.25
chr20_33999186_33999337 0.15 UQCC1
 ubiquinol-cytochrome c reductase complex assembly factor 1
 505
 0.71
chr15_22547843_22548176 0.15 ENSG00000221641
 .
 34729
 0.13

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.1 0.2 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1 0.2 GO:0090382 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.1 0.4 GO:0045059 positive thymic T cell selection(GO:0045059)
0.1 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.2 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.2 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.3 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0002475 antigen processing and presentation via MHC class Ib(GO:0002475)
0.0 0.1 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0051136 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.0 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.0 GO:0002839 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0 0.3 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.7 GO:0006997 nucleus organization(GO:0006997)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.0 GO:0046606 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0002329 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.1 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.2 GO:0000303 response to superoxide(GO:0000303)
0.0 0.2 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.2 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.0 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.1 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.0 GO:0032351 negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0 0.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0031935 regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0006301 postreplication repair(GO:0006301)
0.0 0.0 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.1 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120)
0.0 0.1 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.0 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.0 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.0 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.9 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.2 GO:0032011 ARF protein signal transduction(GO:0032011)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0048541 Peyer's patch development(GO:0048541)
0.0 0.1 GO:0098534 centriole replication(GO:0007099) centriole assembly(GO:0098534)
0.0 0.0 GO:0031507 heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.0 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.0 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.0 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.0 GO:0070265 necrotic cell death(GO:0070265)
0.0 0.0 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.0 GO:0021819 cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.0 0.0 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.1 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.1 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 0.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.0 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.2 GO:0008633 obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0 0.0 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0070076 histone lysine demethylation(GO:0070076)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.1 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.0 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.0 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0072487 MSL complex(GO:0072487)
0.1 0.3 GO:0031264 death-inducing signaling complex(GO:0031264)
0.1 0.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0016585 obsolete chromatin remodeling complex(GO:0016585)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.2 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.0 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.0 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.0 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.0 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.0 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.0 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.3 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0 0.1 GO:0003711 obsolete transcription elongation regulator activity(GO:0003711)
0.0 0.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.0 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0004437 obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0 0.1 GO:1901677 organophosphate ester transmembrane transporter activity(GO:0015605) phosphate transmembrane transporter activity(GO:1901677)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.0 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.0 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.5 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.0 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.0 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling