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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for NR1H2

Z-value: 0.82

Motif logo

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Transcription factors associated with NR1H2

Gene Symbol Gene ID Gene Info
NR1H2
ENSG00000131408.9 nuclear receptor subfamily 1 group H member 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_50879369_50879585NR1H22380.8362000.694.1e-02Click!
chr19_50832551_50833183NR1H2430.7323390.462.1e-01Click!
chr19_50879744_50879984NR1H21340.9082620.442.3e-01Click!
chr19_50833878_50834029NR1H210040.3105660.383.2e-01Click!
chr19_50834536_50834687NR1H216620.1989140.373.2e-01Click!

Activity of the NR1H2 motif across conditions

Conditions sorted by the z-value of the NR1H2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_7145795_7146333 0.44 RREB1
 ras responsive element binding protein 1
 6586
 0.22
chr7_43804203_43804455 0.41 BLVRA
 biliverdin reductase A
 539
 0.79
chr12_54361938_54362089 0.35 HOTAIR
 HOX transcript antisense RNA
 685
 0.4
chr11_47380887_47381038 0.33 MYBPC3
 myosin binding protein C, cardiac
 6709
 0.11
chr19_36398415_36398818 0.33 TYROBP
 TYRO protein tyrosine kinase binding protein
 533
 0.58
chr13_110757726_110757877 0.33 ENSG00000265885
 .
 7303
 0.31
chr3_30655384_30655643 0.33 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 7420
 0.31
chr19_49004358_49004509 0.32 LMTK3
 lemur tyrosine kinase 3
 10628
 0.1
chr10_134369040_134369355 0.31 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 17554
 0.21
chr7_106506867_106507018 0.31 PIK3CG
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
 1018
 0.65
chr2_27109742_27109997 0.31 DPYSL5
 dihydropyrimidinase-like 5
 38493
 0.13
chr14_69422245_69422436 0.30 ACTN1
 actinin, alpha 1
 8075
 0.23
chr19_55766822_55767012 0.30 PPP6R1
 protein phosphatase 6, regulatory subunit 1
 220
 0.84
chr9_140130864_140131015 0.30 TUBB4B
 tubulin, beta 4B class IVb
 4726
 0.06
chr3_12219302_12219453 0.30 TIMP4
 TIMP metallopeptidase inhibitor 4
 18526
 0.25
chr1_10447601_10448200 0.29 ENSG00000265945
 .
 2159
 0.22
chr19_43882588_43882879 0.29 CTC-490G23.4
9611
 0.16
chr7_50345023_50345395 0.29 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 831
 0.74
chr2_139261843_139261994 0.28 SPOPL
 speckle-type POZ protein-like
 2547
 0.45
chr1_1173779_1173930 0.28 B3GALT6
 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
 6225
 0.08
chr3_134324631_134324870 0.28 EPHB1
 EPH receptor B1
 9457
 0.22
chr9_129624166_129624406 0.28 ZBTB34
 zinc finger and BTB domain containing 34
 1342
 0.48
chr16_84809531_84809682 0.27 USP10
 ubiquitin specific peptidase 10
 7733
 0.21
chr1_2321939_2322090 0.27 MORN1
 MORN repeat containing 1
 579
 0.52
chr10_77189804_77189955 0.27 RP11-399K21.10
1467
 0.43
chr16_85604560_85604711 0.27 GSE1
 Gse1 coiled-coil protein
 40380
 0.16
chr5_140996135_140996687 0.26 AC008781.7
1570
 0.23
chr14_106326572_106326804 0.26 ENSG00000265714
 .
 664
 0.18
chr7_129418799_129419025 0.26 ENSG00000207691
 .
 4058
 0.17
chr4_182284557_182284708 0.26 ENSG00000251742
 .
 471629
 0.01
chr1_155220015_155220168 0.25 FAM189B
 family with sequence similarity 189, member B
 4608
 0.07
chr19_3135427_3135578 0.25 GNA15
 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
 689
 0.53
chr4_187491209_187491867 0.24 MTNR1A
 melatonin receptor 1A
 14817
 0.17
chr1_40426265_40426496 0.24 MFSD2A
 major facilitator superfamily domain containing 2A
 5558
 0.17
chr11_16134687_16134838 0.24 ENSG00000221556
 .
 11100
 0.3
chr3_126075576_126075794 0.23 KLF15
 Kruppel-like factor 15
 600
 0.75
chr16_30710458_30711178 0.23 SRCAP
 Snf2-related CREBBP activator protein
 356
 0.48
chr17_76123369_76123520 0.23 TMC6
 transmembrane channel-like 6
 343
 0.8
chr16_23540202_23540353 0.23 GGA2
 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
 6961
 0.14
chr8_144408226_144408377 0.23 TOP1MT
 topoisomerase (DNA) I, mitochondrial
 5680
 0.1
chr19_17622860_17623539 0.23 PGLS
 6-phosphogluconolactonase
 525
 0.61
chr22_46402476_46402694 0.23 WNT7B
 wingless-type MMTV integration site family, member 7B
 29576
 0.1
chr6_10520951_10521149 0.22 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 534
 0.77
chr14_24740164_24740379 0.22 RABGGTA
 Rab geranylgeranyltransferase, alpha subunit
 534
 0.5
chr3_50648522_50648700 0.22 CISH
 cytokine inducible SH2-containing protein
 592
 0.48
chr11_86748898_86749631 0.22 TMEM135
 transmembrane protein 135
 182
 0.97
chr2_201500251_201500402 0.22 AOX1
 aldehyde oxidase 1
 24434
 0.2
chr19_54827917_54828068 0.21 LILRA5
 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
 3583
 0.12
chr1_9690042_9690512 0.21 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 21513
 0.15
chr11_64611077_64611228 0.21 CDC42BPG
 CDC42 binding protein kinase gamma (DMPK-like)
 889
 0.43
chr2_69029555_69029831 0.21 ARHGAP25
 Rho GTPase activating protein 25
 4670
 0.25
chr12_120675375_120675841 0.21 PXN
 paxillin
 10961
 0.12
chr6_41612221_41612372 0.21 MDFI
 MyoD family inhibitor
 6031
 0.16
chr17_1547338_1547608 0.21 SCARF1
 scavenger receptor class F, member 1
 1565
 0.23
chr4_108910417_108910832 0.21 HADH
 hydroxyacyl-CoA dehydrogenase
 246
 0.92
chr4_75550401_75550552 0.21 AC142293.3
35812
 0.18
chr20_58633559_58633836 0.21 C20orf197
 chromosome 20 open reading frame 197
 2717
 0.35
chr3_37598700_37598851 0.21 ENSG00000239105
 .
 15929
 0.25
chr11_44592282_44592433 0.21 CD82
 CD82 molecule
 2271
 0.34
chr9_95716734_95716885 0.20 FGD3
 FYVE, RhoGEF and PH domain containing 3
 7076
 0.22
chr19_55770559_55770710 0.20 PPP6R1
 protein phosphatase 6, regulatory subunit 1
 271
 0.8
chr1_2805652_2805803 0.20 TTC34
 tetratricopeptide repeat domain 34
 87441
 0.08
chr20_33878344_33878495 0.20 FAM83C
 family with sequence similarity 83, member C
 1785
 0.2
chr6_15246387_15247495 0.20 JARID2
 jumonji, AT rich interactive domain 2
 414
 0.82
chr6_120039243_120039394 0.20 ENSG00000265725
 .
 297007
 0.01
chr14_102976422_102976710 0.20 ANKRD9
 ankyrin repeat domain 9
 430
 0.81
chr19_52154679_52154830 0.20 SIGLEC5
 sialic acid binding Ig-like lectin 5
 4603
 0.12
chr8_144951605_144951756 0.20 EPPK1
 epiplakin 1
 952
 0.39
chr3_48955621_48956131 0.19 ARIH2
 ariadne RBR E3 ubiquitin protein ligase 2
 378
 0.68
chr16_85649875_85650315 0.19 GSE1
 Gse1 coiled-coil protein
 3137
 0.26
chr8_19797296_19797595 0.19 LPL
 lipoprotein lipase
 963
 0.69
chr3_15482302_15482608 0.19 EAF1-AS1
 EAF1 antisense RNA 1
 354
 0.48
chr4_79580897_79581048 0.19 ENSG00000238816
 .
 19718
 0.2
chr3_151608599_151608750 0.19 SUCNR1
 succinate receptor 1
 17243
 0.21
chr20_39676850_39677439 0.19 TOP1
 topoisomerase (DNA) I
 19686
 0.2
chr17_35716056_35716207 0.19 ACACA
 acetyl-CoA carboxylase alpha
 72
 0.97
chr2_225455716_225455867 0.18 CUL3
 cullin 3
 5681
 0.34
chr11_58342434_58343027 0.18 LPXN
 leupaxin
 604
 0.68
chr16_1451750_1451901 0.18 LA16c-312E8.2
7010
 0.08
chr2_74198290_74198479 0.18 ENSG00000201876
 .
 3051
 0.21
chr10_102133099_102133250 0.18 ENSG00000212325
 .
 25029
 0.12
chr19_42302290_42302441 0.18 CEACAM3
 carcinoembryonic antigen-related cell adhesion molecule 3
 1280
 0.33
chr15_81591495_81592151 0.18 IL16
 interleukin 16
 66
 0.98
chr18_21296917_21297068 0.18 LAMA3
 laminin, alpha 3
 27344
 0.2
chr16_85591287_85591449 0.18 GSE1
 Gse1 coiled-coil protein
 53647
 0.13
chr8_72648716_72648867 0.18 ENSG00000200191
 .
 79069
 0.09
chr22_39493202_39493353 0.18 APOBEC3H
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
 3
 0.97
chr10_72147214_72147395 0.17 LRRC20
 leucine rich repeat containing 20
 4922
 0.2
chr12_120972611_120972974 0.17 RNF10
 ring finger protein 10
 177
 0.79
chr12_123210436_123210665 0.17 HCAR1
 hydroxycarboxylic acid receptor 1
 4579
 0.15
chr4_140967052_140967203 0.17 RP11-392B6.1
82042
 0.1
chrX_153979641_153979978 0.17 GAB3
 GRB2-associated binding protein 3
 457
 0.73
chr19_43058209_43058360 0.17 CEACAM1
 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
 7102
 0.19
chrX_38663358_38663509 0.17 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 297
 0.64
chr1_150533351_150533580 0.17 ADAMTSL4-AS1
 ADAMTSL4 antisense RNA 1
 504
 0.58
chr2_85197275_85197757 0.17 KCMF1
 potassium channel modulatory factor 1
 700
 0.74
chr17_57297960_57298694 0.17 GDPD1
 glycerophosphodiester phosphodiesterase domain containing 1
 404
 0.75
chr6_79787718_79787933 0.17 PHIP
 pleckstrin homology domain interacting protein
 128
 0.98
chr8_144699859_144700339 0.17 TSTA3
 tissue specific transplantation antigen P35B
 119
 0.9
chr6_157097564_157098248 0.17 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 1157
 0.47
chr9_113799034_113800104 0.17 LPAR1
 lysophosphatidic acid receptor 1
 754
 0.74
chr20_10600368_10600683 0.17 JAG1
 jagged 1
 42629
 0.18
chr5_134722208_134722661 0.17 H2AFY
 H2A histone family, member Y
 12467
 0.16
chr21_46302756_46302907 0.17 PTTG1IP
 pituitary tumor-transforming 1 interacting protein
 9079
 0.12
chr4_71704020_71704773 0.16 GRSF1
 G-rich RNA sequence binding factor 1
 322
 0.85
chr1_27159845_27160009 0.16 ZDHHC18
 zinc finger, DHHC-type containing 18
 1416
 0.28
chr20_62184252_62184657 0.16 C20orf195
 chromosome 20 open reading frame 195
 81
 0.94
chr8_125861063_125861214 0.16 ENSG00000263735
 .
 26838
 0.22
chr13_30267815_30267966 0.16 SLC7A1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 98065
 0.08
chr11_3886844_3887200 0.16 STIM1
 stromal interaction molecule 1
 1311
 0.29
chr2_224701437_224701763 0.16 AP1S3
 adaptor-related protein complex 1, sigma 3 subunit
 601
 0.83
chr12_105076123_105076407 0.16 ENSG00000264295
 .
 90854
 0.08
chr1_150949314_150950272 0.16 CERS2
 ceramide synthase 2
 2314
 0.14
chr1_202829892_202830043 0.16 RP11-480I12.5
1740
 0.26
chr14_65175690_65176293 0.16 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 4676
 0.25
chr17_80056849_80057346 0.16 FASN
 fatty acid synthase
 889
 0.36
chr13_67732158_67732309 0.16 PCDH9
 protocadherin 9
 70339
 0.13
chr7_55121925_55122165 0.15 EGFR
 epidermal growth factor receptor
 35234
 0.22
chr8_38691975_38692126 0.15 RP11-723D22.3
11907
 0.16
chr5_74964815_74965486 0.15 ENSG00000207333
 .
 40274
 0.14
chr19_38806035_38806435 0.15 YIF1B
 Yip1 interacting factor homolog B (S. cerevisiae)
 173
 0.87
chr2_109204886_109205231 0.15 LIMS1
 LIM and senescent cell antigen-like domains 1
 136
 0.97
chr12_82554330_82554481 0.15 ENSG00000221260
 .
 104317
 0.08
chr7_36247494_36247909 0.15 AC007327.5
23015
 0.2
chr2_158299843_158300108 0.15 CYTIP
 cytohesin 1 interacting protein
 679
 0.68
chr3_172240144_172241280 0.15 TNFSF10
 tumor necrosis factor (ligand) superfamily, member 10
 553
 0.83
chr18_74716892_74717079 0.15 MBP
 myelin basic protein
 5093
 0.27
chr3_16883621_16883873 0.15 PLCL2
 phospholipase C-like 2
 42705
 0.19
chr8_23510263_23510414 0.14 NKX3-1
 NK3 homeobox 1
 30064
 0.14
chr8_48642101_48642252 0.14 SPIDR
 scaffolding protein involved in DNA repair
 2361
 0.28
chr16_57831764_57831915 0.14 KIFC3
 kinesin family member C3
 90
 0.96
chr1_73682669_73682820 0.14 ENSG00000251825
 .
 25206
 0.28
chr22_22173562_22173713 0.14 ENSG00000200985
 .
 26914
 0.13
chr2_75076571_75077006 0.14 HK2
 hexokinase 2
 14491
 0.24
chr17_41622724_41622875 0.14 ETV4
 ets variant 4
 240
 0.78
chr12_9912992_9913534 0.14 CD69
 CD69 molecule
 234
 0.92
chr18_43146663_43146829 0.14 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 48020
 0.13
chr1_95261259_95261410 0.14 SLC44A3
 solute carrier family 44, member 3
 24564
 0.19
chr16_2566413_2567218 0.14 ATP6V0C
 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
 2185
 0.1
chr22_23579910_23580061 0.14 BCR
 breakpoint cluster region
 16162
 0.16
chr10_104405800_104406167 0.14 TRIM8
 tripartite motif containing 8
 1339
 0.42
chr11_43965819_43966142 0.14 C11orf96
 chromosome 11 open reading frame 96
 1925
 0.3
chr6_72077062_72077213 0.14 ENSG00000199094
 .
 9597
 0.21
chr12_27485485_27485755 0.13 ARNTL2
 aryl hydrocarbon receptor nuclear translocator-like 2
 167
 0.96
chr1_169679248_169679951 0.13 SELL
 selectin L
 1240
 0.48
chr1_11902762_11902970 0.13 NPPA-AS1
 NPPA antisense RNA 1
 1052
 0.37
chr21_40179962_40180113 0.13 ETS2
 v-ets avian erythroblastosis virus E26 oncogene homolog 2
 1523
 0.53
chr1_3540485_3541321 0.13 RP11-46F15.2
404
 0.59
chr5_80215972_80216123 0.13 CTC-459I6.1
32752
 0.19
chr1_230410321_230410472 0.13 RP5-956O18.2
6167
 0.24
chr12_11804572_11805680 0.13 ETV6
 ets variant 6
 2338
 0.4
chr17_38486750_38487092 0.13 RARA
 retinoic acid receptor, alpha
 10719
 0.11
chr11_73093161_73093312 0.13 RELT
 RELT tumor necrosis factor receptor
 5523
 0.16
chr10_116127396_116127547 0.13 AFAP1L2
 actin filament associated protein 1-like 2
 36768
 0.17
chr10_3510829_3511012 0.13 RP11-184A2.3
282339
 0.01
chr14_24808275_24808901 0.13 RIPK3
 receptor-interacting serine-threonine kinase 3
 663
 0.41
chr17_56405277_56405428 0.13 BZRAP1
 benzodiazepine receptor (peripheral) associated protein 1
 93
 0.91
chr10_129863856_129864007 0.13 PTPRE
 protein tyrosine phosphatase, receptor type, E
 18097
 0.25
chr4_130014442_130014634 0.13 SCLT1
 sodium channel and clathrin linker 1
 6
 0.54
chr22_45730655_45730806 0.13 FAM118A
 family with sequence similarity 118, member A
 5205
 0.22
chr4_184063920_184064196 0.13 ENSG00000252702
 .
 26512
 0.16
chr18_34409568_34409805 0.13 KIAA1328
 KIAA1328
 483
 0.5
chr6_11093389_11093895 0.13 SMIM13
 small integral membrane protein 13
 624
 0.67
chr15_70391403_70391876 0.12 TLE3
 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
 1124
 0.58
chr2_73297200_73297351 0.12 SFXN5
 sideroflexin 5
 1527
 0.42
chr10_79637658_79637809 0.12 AL391421.1
 Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964
 11100
 0.18
chr22_40415035_40415186 0.12 FAM83F
 family with sequence similarity 83, member F
 9418
 0.17
chr11_441089_441413 0.12 ENSG00000243562
 .
 558
 0.44
chr3_197677297_197678136 0.12 RPL35A
 ribosomal protein L35a
 288
 0.79
chr2_220462950_220463200 0.12 STK11IP
 serine/threonine kinase 11 interacting protein
 479
 0.64
chr19_12896715_12896961 0.12 ENSG00000263800
 .
 1104
 0.23
chr11_111749891_111750174 0.12 C11orf1
 chromosome 11 open reading frame 1
 84
 0.55
chr11_46639581_46640063 0.12 HARBI1
 harbinger transposase derived 1
 363
 0.56
chr3_57530329_57530480 0.12 DNAH12
 dynein, axonemal, heavy chain 12
 333
 0.79
chr9_138967584_138968045 0.12 NACC2
 NACC family member 2, BEN and BTB (POZ) domain containing
 19317
 0.19
chr17_55335025_55335422 0.12 MSI2
 musashi RNA-binding protein 2
 844
 0.72
chr11_3860853_3861244 0.12 RHOG
 ras homolog family member G
 1024
 0.35
chr16_3018938_3019181 0.12 PAQR4
 progestin and adipoQ receptor family member IV
 187
 0.85
chr19_58919335_58919902 0.12 ZNF584
 zinc finger protein 584
 374
 0.67
chr17_17727205_17727405 0.12 SREBF1
 sterol regulatory element binding transcription factor 1
 373
 0.81
chr22_40574055_40575183 0.12 TNRC6B
 trinucleotide repeat containing 6B
 673
 0.79
chr9_114424483_114425187 0.12 GNG10
 guanine nucleotide binding protein (G protein), gamma 10
 1220
 0.43
chr3_41244711_41244955 0.12 CTNNB1
 catenin (cadherin-associated protein), beta 1, 88kDa
 3231
 0.41
chr6_159103866_159104017 0.12 SYTL3
 synaptotagmin-like 3
 19746
 0.18
chr2_238876520_238877346 0.12 UBE2F
 ubiquitin-conjugating enzyme E2F (putative)
 502
 0.82
chr20_37359167_37359318 0.11 SLC32A1
 solute carrier family 32 (GABA vesicular transporter), member 1
 6137
 0.18
chr18_9488845_9488996 0.11 RALBP1
 ralA binding protein 1
 12787
 0.15
chr12_93984725_93985802 0.11 SOCS2
 suppressor of cytokine signaling 2
 16429
 0.18
chr2_95943344_95943495 0.11 PROM2
 prominin 2
 3174
 0.28
chr12_39298878_39299365 0.11 CPNE8
 copine VIII
 312
 0.84
chr1_202923356_202923584 0.11 ADIPOR1
 adiponectin receptor 1
 3943
 0.14
chr3_50648196_50648499 0.11 CISH
 cytokine inducible SH2-containing protein
 856
 0.4
chr1_40849833_40850457 0.11 SMAP2
 small ArfGAP2
 9825
 0.18
chr14_45603973_45604448 0.11 FKBP3
 FK506 binding protein 3, 25kDa
 312
 0.77
chr20_2489860_2490111 0.11 ZNF343
 zinc finger protein 343
 207
 0.92
chr12_49246930_49247081 0.11 DDX23
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
 1059
 0.33
chr17_42173254_42173470 0.11 HDAC5
 histone deacetylase 5
 2807
 0.14
chr4_2802491_2802761 0.11 SH3BP2
 SH3-domain binding protein 2
 1901
 0.35
chr12_56122984_56124090 0.11 CD63
 CD63 molecule
 46
 0.89
chr1_1072756_1072964 0.11 C1orf159
 chromosome 1 open reading frame 159
 21119
 0.08

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.1 0.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.3 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.2 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0032049 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.2 GO:0034331 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0014010 Schwann cell proliferation(GO:0014010)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.3 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.0 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.0 GO:0032971 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0 0.0 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.0 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0 0.2 GO:0018208 peptidyl-proline modification(GO:0018208)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.1 GO:0075713 establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.0 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.0 0.0 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0014009 glial cell proliferation(GO:0014009)
0.0 0.1 GO:0021873 forebrain neuroblast division(GO:0021873)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0070822 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.2 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.2 GO:0001228 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.0 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.0 GO:0004739 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins