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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NR1H2

Z-value: 0.82

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Transcription factors associated with NR1H2

Gene Symbol	Gene ID	Gene Info
NR1H2 Ensembl NCBI GeneCards UniProt	ENSG00000131408.9	NR1H2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NR1H2	chr19_50879369_50879585	238	0.836200	0.69	4.1e-02	Click!
NR1H2	chr19_50832551_50833183	43	0.732339	0.46	2.1e-01	Click!
NR1H2	chr19_50879744_50879984	134	0.908262	0.44	2.3e-01	Click!
NR1H2	chr19_50833878_50834029	1004	0.310566	0.38	3.2e-01	Click!
NR1H2	chr19_50834536_50834687	1662	0.198914	0.37	3.2e-01	Click!

Activity of the NR1H2 motif across conditions

Conditions sorted by the z-value of the NR1H2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_7145795_7146333	0.44	RREB1	ras responsive element binding protein 1	6586	0.22
chr7_43804203_43804455	0.41	BLVRA	biliverdin reductase A	539	0.79
chr12_54361938_54362089	0.35	HOTAIR	HOX transcript antisense RNA	685	0.4
chr11_47380887_47381038	0.33	MYBPC3	myosin binding protein C, cardiac	6709	0.11
chr19_36398415_36398818	0.33	TYROBP	TYRO protein tyrosine kinase binding protein	533	0.58
chr13_110757726_110757877	0.33	ENSG00000265885	.	7303	0.31
chr3_30655384_30655643	0.33	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	7420	0.31
chr19_49004358_49004509	0.32	LMTK3	lemur tyrosine kinase 3	10628	0.1
chr10_134369040_134369355	0.31	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	17554	0.21
chr7_106506867_106507018	0.31	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1018	0.65
chr2_27109742_27109997	0.31	DPYSL5	dihydropyrimidinase-like 5	38493	0.13
chr14_69422245_69422436	0.30	ACTN1	actinin, alpha 1	8075	0.23
chr19_55766822_55767012	0.30	PPP6R1	protein phosphatase 6, regulatory subunit 1	220	0.84
chr9_140130864_140131015	0.30	TUBB4B	tubulin, beta 4B class IVb	4726	0.06
chr3_12219302_12219453	0.30	TIMP4	TIMP metallopeptidase inhibitor 4	18526	0.25
chr1_10447601_10448200	0.29	ENSG00000265945	.	2159	0.22
chr19_43882588_43882879	0.29	CTC-490G23.4		9611	0.16
chr7_50345023_50345395	0.29	IKZF1	IKAROS family zinc finger 1 (Ikaros)	831	0.74
chr2_139261843_139261994	0.28	SPOPL	speckle-type POZ protein-like	2547	0.45
chr1_1173779_1173930	0.28	B3GALT6	UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6	6225	0.08
chr3_134324631_134324870	0.28	EPHB1	EPH receptor B1	9457	0.22
chr9_129624166_129624406	0.28	ZBTB34	zinc finger and BTB domain containing 34	1342	0.48
chr16_84809531_84809682	0.27	USP10	ubiquitin specific peptidase 10	7733	0.21
chr1_2321939_2322090	0.27	MORN1	MORN repeat containing 1	579	0.52
chr10_77189804_77189955	0.27	RP11-399K21.10		1467	0.43
chr16_85604560_85604711	0.27	GSE1	Gse1 coiled-coil protein	40380	0.16
chr5_140996135_140996687	0.26	AC008781.7		1570	0.23
chr14_106326572_106326804	0.26	ENSG00000265714	.	664	0.18
chr7_129418799_129419025	0.26	ENSG00000207691	.	4058	0.17
chr4_182284557_182284708	0.26	ENSG00000251742	.	471629	0.01
chr1_155220015_155220168	0.25	FAM189B	family with sequence similarity 189, member B	4608	0.07
chr19_3135427_3135578	0.25	GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	689	0.53
chr4_187491209_187491867	0.24	MTNR1A	melatonin receptor 1A	14817	0.17
chr1_40426265_40426496	0.24	MFSD2A	major facilitator superfamily domain containing 2A	5558	0.17
chr11_16134687_16134838	0.24	ENSG00000221556	.	11100	0.3
chr3_126075576_126075794	0.23	KLF15	Kruppel-like factor 15	600	0.75
chr16_30710458_30711178	0.23	SRCAP	Snf2-related CREBBP activator protein	356	0.48
chr17_76123369_76123520	0.23	TMC6	transmembrane channel-like 6	343	0.8
chr16_23540202_23540353	0.23	GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	6961	0.14
chr8_144408226_144408377	0.23	TOP1MT	topoisomerase (DNA) I, mitochondrial	5680	0.1
chr19_17622860_17623539	0.23	PGLS	6-phosphogluconolactonase	525	0.61
chr22_46402476_46402694	0.23	WNT7B	wingless-type MMTV integration site family, member 7B	29576	0.1
chr6_10520951_10521149	0.22	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	534	0.77
chr14_24740164_24740379	0.22	RABGGTA	Rab geranylgeranyltransferase, alpha subunit	534	0.5
chr3_50648522_50648700	0.22	CISH	cytokine inducible SH2-containing protein	592	0.48
chr11_86748898_86749631	0.22	TMEM135	transmembrane protein 135	182	0.97
chr2_201500251_201500402	0.22	AOX1	aldehyde oxidase 1	24434	0.2
chr19_54827917_54828068	0.21	LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	3583	0.12
chr1_9690042_9690512	0.21	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	21513	0.15
chr11_64611077_64611228	0.21	CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	889	0.43
chr2_69029555_69029831	0.21	ARHGAP25	Rho GTPase activating protein 25	4670	0.25
chr12_120675375_120675841	0.21	PXN	paxillin	10961	0.12
chr6_41612221_41612372	0.21	MDFI	MyoD family inhibitor	6031	0.16
chr17_1547338_1547608	0.21	SCARF1	scavenger receptor class F, member 1	1565	0.23
chr4_108910417_108910832	0.21	HADH	hydroxyacyl-CoA dehydrogenase	246	0.92
chr4_75550401_75550552	0.21	AC142293.3		35812	0.18
chr20_58633559_58633836	0.21	C20orf197	chromosome 20 open reading frame 197	2717	0.35
chr3_37598700_37598851	0.21	ENSG00000239105	.	15929	0.25
chr11_44592282_44592433	0.21	CD82	CD82 molecule	2271	0.34
chr9_95716734_95716885	0.20	FGD3	FYVE, RhoGEF and PH domain containing 3	7076	0.22
chr19_55770559_55770710	0.20	PPP6R1	protein phosphatase 6, regulatory subunit 1	271	0.8
chr1_2805652_2805803	0.20	TTC34	tetratricopeptide repeat domain 34	87441	0.08
chr20_33878344_33878495	0.20	FAM83C	family with sequence similarity 83, member C	1785	0.2
chr6_15246387_15247495	0.20	JARID2	jumonji, AT rich interactive domain 2	414	0.82
chr6_120039243_120039394	0.20	ENSG00000265725	.	297007	0.01
chr14_102976422_102976710	0.20	ANKRD9	ankyrin repeat domain 9	430	0.81
chr19_52154679_52154830	0.20	SIGLEC5	sialic acid binding Ig-like lectin 5	4603	0.12
chr8_144951605_144951756	0.20	EPPK1	epiplakin 1	952	0.39
chr3_48955621_48956131	0.19	ARIH2	ariadne RBR E3 ubiquitin protein ligase 2	378	0.68
chr16_85649875_85650315	0.19	GSE1	Gse1 coiled-coil protein	3137	0.26
chr8_19797296_19797595	0.19	LPL	lipoprotein lipase	963	0.69
chr3_15482302_15482608	0.19	EAF1-AS1	EAF1 antisense RNA 1	354	0.48
chr4_79580897_79581048	0.19	ENSG00000238816	.	19718	0.2
chr3_151608599_151608750	0.19	SUCNR1	succinate receptor 1	17243	0.21
chr20_39676850_39677439	0.19	TOP1	topoisomerase (DNA) I	19686	0.2
chr17_35716056_35716207	0.19	ACACA	acetyl-CoA carboxylase alpha	72	0.97
chr2_225455716_225455867	0.18	CUL3	cullin 3	5681	0.34
chr11_58342434_58343027	0.18	LPXN	leupaxin	604	0.68
chr16_1451750_1451901	0.18	LA16c-312E8.2		7010	0.08
chr2_74198290_74198479	0.18	ENSG00000201876	.	3051	0.21
chr10_102133099_102133250	0.18	ENSG00000212325	.	25029	0.12
chr19_42302290_42302441	0.18	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	1280	0.33
chr15_81591495_81592151	0.18	IL16	interleukin 16	66	0.98
chr18_21296917_21297068	0.18	LAMA3	laminin, alpha 3	27344	0.2
chr16_85591287_85591449	0.18	GSE1	Gse1 coiled-coil protein	53647	0.13
chr8_72648716_72648867	0.18	ENSG00000200191	.	79069	0.09
chr22_39493202_39493353	0.18	APOBEC3H	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H	3	0.97
chr10_72147214_72147395	0.17	LRRC20	leucine rich repeat containing 20	4922	0.2
chr12_120972611_120972974	0.17	RNF10	ring finger protein 10	177	0.79
chr12_123210436_123210665	0.17	HCAR1	hydroxycarboxylic acid receptor 1	4579	0.15
chr4_140967052_140967203	0.17	RP11-392B6.1		82042	0.1
chrX_153979641_153979978	0.17	GAB3	GRB2-associated binding protein 3	457	0.73
chr19_43058209_43058360	0.17	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	7102	0.19
chrX_38663358_38663509	0.17	MID1IP1-AS1	MID1IP1 antisense RNA 1	297	0.64
chr1_150533351_150533580	0.17	ADAMTSL4-AS1	ADAMTSL4 antisense RNA 1	504	0.58
chr2_85197275_85197757	0.17	KCMF1	potassium channel modulatory factor 1	700	0.74
chr17_57297960_57298694	0.17	GDPD1	glycerophosphodiester phosphodiesterase domain containing 1	404	0.75
chr6_79787718_79787933	0.17	PHIP	pleckstrin homology domain interacting protein	128	0.98
chr8_144699859_144700339	0.17	TSTA3	tissue specific transplantation antigen P35B	119	0.9
chr6_157097564_157098248	0.17	ARID1B	AT rich interactive domain 1B (SWI1-like)	1157	0.47
chr9_113799034_113800104	0.17	LPAR1	lysophosphatidic acid receptor 1	754	0.74
chr20_10600368_10600683	0.17	JAG1	jagged 1	42629	0.18
chr5_134722208_134722661	0.17	H2AFY	H2A histone family, member Y	12467	0.16
chr21_46302756_46302907	0.17	PTTG1IP	pituitary tumor-transforming 1 interacting protein	9079	0.12
chr4_71704020_71704773	0.16	GRSF1	G-rich RNA sequence binding factor 1	322	0.85
chr1_27159845_27160009	0.16	ZDHHC18	zinc finger, DHHC-type containing 18	1416	0.28
chr20_62184252_62184657	0.16	C20orf195	chromosome 20 open reading frame 195	81	0.94
chr8_125861063_125861214	0.16	ENSG00000263735	.	26838	0.22
chr13_30267815_30267966	0.16	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	98065	0.08
chr11_3886844_3887200	0.16	STIM1	stromal interaction molecule 1	1311	0.29
chr2_224701437_224701763	0.16	AP1S3	adaptor-related protein complex 1, sigma 3 subunit	601	0.83
chr12_105076123_105076407	0.16	ENSG00000264295	.	90854	0.08
chr1_150949314_150950272	0.16	CERS2	ceramide synthase 2	2314	0.14
chr1_202829892_202830043	0.16	RP11-480I12.5		1740	0.26
chr14_65175690_65176293	0.16	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	4676	0.25
chr17_80056849_80057346	0.16	FASN	fatty acid synthase	889	0.36
chr13_67732158_67732309	0.16	PCDH9	protocadherin 9	70339	0.13
chr7_55121925_55122165	0.15	EGFR	epidermal growth factor receptor	35234	0.22
chr8_38691975_38692126	0.15	RP11-723D22.3		11907	0.16
chr5_74964815_74965486	0.15	ENSG00000207333	.	40274	0.14
chr19_38806035_38806435	0.15	YIF1B	Yip1 interacting factor homolog B (S. cerevisiae)	173	0.87
chr2_109204886_109205231	0.15	LIMS1	LIM and senescent cell antigen-like domains 1	136	0.97
chr12_82554330_82554481	0.15	ENSG00000221260	.	104317	0.08
chr7_36247494_36247909	0.15	AC007327.5		23015	0.2
chr2_158299843_158300108	0.15	CYTIP	cytohesin 1 interacting protein	679	0.68
chr3_172240144_172241280	0.15	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	553	0.83
chr18_74716892_74717079	0.15	MBP	myelin basic protein	5093	0.27
chr3_16883621_16883873	0.15	PLCL2	phospholipase C-like 2	42705	0.19
chr8_23510263_23510414	0.14	NKX3-1	NK3 homeobox 1	30064	0.14
chr8_48642101_48642252	0.14	SPIDR	scaffolding protein involved in DNA repair	2361	0.28
chr16_57831764_57831915	0.14	KIFC3	kinesin family member C3	90	0.96
chr1_73682669_73682820	0.14	ENSG00000251825	.	25206	0.28
chr22_22173562_22173713	0.14	ENSG00000200985	.	26914	0.13
chr2_75076571_75077006	0.14	HK2	hexokinase 2	14491	0.24
chr17_41622724_41622875	0.14	ETV4	ets variant 4	240	0.78
chr12_9912992_9913534	0.14	CD69	CD69 molecule	234	0.92
chr18_43146663_43146829	0.14	SLC14A2	solute carrier family 14 (urea transporter), member 2	48020	0.13
chr1_95261259_95261410	0.14	SLC44A3	solute carrier family 44, member 3	24564	0.19
chr16_2566413_2567218	0.14	ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	2185	0.1
chr22_23579910_23580061	0.14	BCR	breakpoint cluster region	16162	0.16
chr10_104405800_104406167	0.14	TRIM8	tripartite motif containing 8	1339	0.42
chr11_43965819_43966142	0.14	C11orf96	chromosome 11 open reading frame 96	1925	0.3
chr6_72077062_72077213	0.14	ENSG00000199094	.	9597	0.21
chr12_27485485_27485755	0.13	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	167	0.96
chr1_169679248_169679951	0.13	SELL	selectin L	1240	0.48
chr1_11902762_11902970	0.13	NPPA-AS1	NPPA antisense RNA 1	1052	0.37
chr21_40179962_40180113	0.13	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	1523	0.53
chr1_3540485_3541321	0.13	RP11-46F15.2		404	0.59
chr5_80215972_80216123	0.13	CTC-459I6.1		32752	0.19
chr1_230410321_230410472	0.13	RP5-956O18.2		6167	0.24
chr12_11804572_11805680	0.13	ETV6	ets variant 6	2338	0.4
chr17_38486750_38487092	0.13	RARA	retinoic acid receptor, alpha	10719	0.11
chr11_73093161_73093312	0.13	RELT	RELT tumor necrosis factor receptor	5523	0.16
chr10_116127396_116127547	0.13	AFAP1L2	actin filament associated protein 1-like 2	36768	0.17
chr10_3510829_3511012	0.13	RP11-184A2.3		282339	0.01
chr14_24808275_24808901	0.13	RIPK3	receptor-interacting serine-threonine kinase 3	663	0.41
chr17_56405277_56405428	0.13	BZRAP1	benzodiazepine receptor (peripheral) associated protein 1	93	0.91
chr10_129863856_129864007	0.13	PTPRE	protein tyrosine phosphatase, receptor type, E	18097	0.25
chr4_130014442_130014634	0.13	SCLT1	sodium channel and clathrin linker 1	6	0.54
chr22_45730655_45730806	0.13	FAM118A	family with sequence similarity 118, member A	5205	0.22
chr4_184063920_184064196	0.13	ENSG00000252702	.	26512	0.16
chr18_34409568_34409805	0.13	KIAA1328	KIAA1328	483	0.5
chr6_11093389_11093895	0.13	SMIM13	small integral membrane protein 13	624	0.67
chr15_70391403_70391876	0.12	TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	1124	0.58
chr2_73297200_73297351	0.12	SFXN5	sideroflexin 5	1527	0.42
chr10_79637658_79637809	0.12	AL391421.1	Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964	11100	0.18
chr22_40415035_40415186	0.12	FAM83F	family with sequence similarity 83, member F	9418	0.17
chr11_441089_441413	0.12	ENSG00000243562	.	558	0.44
chr3_197677297_197678136	0.12	RPL35A	ribosomal protein L35a	288	0.79
chr2_220462950_220463200	0.12	STK11IP	serine/threonine kinase 11 interacting protein	479	0.64
chr19_12896715_12896961	0.12	ENSG00000263800	.	1104	0.23
chr11_111749891_111750174	0.12	C11orf1	chromosome 11 open reading frame 1	84	0.55
chr11_46639581_46640063	0.12	HARBI1	harbinger transposase derived 1	363	0.56
chr3_57530329_57530480	0.12	DNAH12	dynein, axonemal, heavy chain 12	333	0.79
chr9_138967584_138968045	0.12	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	19317	0.19
chr17_55335025_55335422	0.12	MSI2	musashi RNA-binding protein 2	844	0.72
chr11_3860853_3861244	0.12	RHOG	ras homolog family member G	1024	0.35
chr16_3018938_3019181	0.12	PAQR4	progestin and adipoQ receptor family member IV	187	0.85
chr19_58919335_58919902	0.12	ZNF584	zinc finger protein 584	374	0.67
chr17_17727205_17727405	0.12	SREBF1	sterol regulatory element binding transcription factor 1	373	0.81
chr22_40574055_40575183	0.12	TNRC6B	trinucleotide repeat containing 6B	673	0.79
chr9_114424483_114425187	0.12	GNG10	guanine nucleotide binding protein (G protein), gamma 10	1220	0.43
chr3_41244711_41244955	0.12	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	3231	0.41
chr6_159103866_159104017	0.12	SYTL3	synaptotagmin-like 3	19746	0.18
chr2_238876520_238877346	0.12	UBE2F	ubiquitin-conjugating enzyme E2F (putative)	502	0.82
chr20_37359167_37359318	0.11	SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	6137	0.18
chr18_9488845_9488996	0.11	RALBP1	ralA binding protein 1	12787	0.15
chr12_93984725_93985802	0.11	SOCS2	suppressor of cytokine signaling 2	16429	0.18
chr2_95943344_95943495	0.11	PROM2	prominin 2	3174	0.28
chr12_39298878_39299365	0.11	CPNE8	copine VIII	312	0.84
chr1_202923356_202923584	0.11	ADIPOR1	adiponectin receptor 1	3943	0.14
chr3_50648196_50648499	0.11	CISH	cytokine inducible SH2-containing protein	856	0.4
chr1_40849833_40850457	0.11	SMAP2	small ArfGAP2	9825	0.18
chr14_45603973_45604448	0.11	FKBP3	FK506 binding protein 3, 25kDa	312	0.77
chr20_2489860_2490111	0.11	ZNF343	zinc finger protein 343	207	0.92
chr12_49246930_49247081	0.11	DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	1059	0.33
chr17_42173254_42173470	0.11	HDAC5	histone deacetylase 5	2807	0.14
chr4_2802491_2802761	0.11	SH3BP2	SH3-domain binding protein 2	1901	0.35
chr12_56122984_56124090	0.11	CD63	CD63 molecule	46	0.89
chr1_1072756_1072964	0.11	C1orf159	chromosome 1 open reading frame 159	21119	0.08

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.1	0.2	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1	0.3	GO:0033015	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.2	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.2	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.1	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.2	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0032049	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.2	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.4	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0014010	Schwann cell proliferation(GO:0014010)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.3	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.2	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.3	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.2	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0032971	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.0	GO:0070572	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0	0.2	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.1	GO:0075713	establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.0	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.0	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0014009	glial cell proliferation(GO:0014009)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2	GO:0005915	zonula adherens(GO:0005915)
0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	GO:0001740	Barr body(GO:0001740)
0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	GO:0005682	U5 snRNP(GO:0005682)
0.1	GO:0031143	pseudopodium(GO:0031143)
0.1	GO:0005614	interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.4	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.2	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.2	GO:0001228	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.2	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.3	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.0	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.3	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins