Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NR1H4

Z-value: 1.13

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Transcription factors associated with NR1H4

Gene Symbol Gene ID Gene Info
NR1H4
ENSG00000012504.9 NR1H4

Activity of the NR1H4 motif across conditions

Conditions sorted by the z-value of the NR1H4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_32718037_32718210 1.08 LCK
 lymphocyte-specific protein tyrosine kinase
 1248
 0.25
chr17_43302327_43302665 0.90 CTD-2020K17.1
2907
 0.13
chr11_117857636_117858098 0.88 IL10RA
 interleukin 10 receptor, alpha
 758
 0.66
chr1_169679248_169679951 0.83 SELL
 selectin L
 1240
 0.48
chr14_22978649_22978851 0.75 TRAJ15
 T cell receptor alpha joining 15
 19830
 0.09
chr6_133084105_133084393 0.75 VNN2
 vanin 2
 321
 0.83
chr17_66234126_66234354 0.75 AMZ2
 archaelysin family metallopeptidase 2
 9475
 0.16
chr1_32718292_32718517 0.75 LCK
 lymphocyte-specific protein tyrosine kinase
 1529
 0.2
chr18_67623845_67624178 0.74 CD226
 CD226 molecule
 105
 0.98
chr19_17515838_17515989 0.72 BST2
 bone marrow stromal cell antigen 2
 544
 0.39
chr3_32995983_32996275 0.71 CCR4
 chemokine (C-C motif) receptor 4
 3063
 0.34
chr1_154926867_154927056 0.69 PBXIP1
 pre-B-cell leukemia homeobox interacting protein 1
 1619
 0.18
chr19_39108076_39108634 0.67 MAP4K1
 mitogen-activated protein kinase kinase kinase kinase 1
 209
 0.87
chr19_18197501_18197724 0.66 IL12RB1
 interleukin 12 receptor, beta 1
 130
 0.95
chr14_100533458_100533776 0.65 EVL
 Enah/Vasp-like
 843
 0.55
chr19_16254556_16255035 0.64 HSH2D
 hematopoietic SH2 domain containing
 249
 0.88
chr22_50987475_50987644 0.63 KLHDC7B
 kelch domain containing 7B
 1097
 0.24
chr17_75450125_75450790 0.62 SEPT9
 septin 9
 295
 0.88
chr1_39681454_39681741 0.60 RP11-416A14.1
9413
 0.17
chr19_55008953_55009477 0.60 LAIR2
 leukocyte-associated immunoglobulin-like receptor 2
 115
 0.93
chr5_98362367_98362646 0.59 ENSG00000200351
 .
 90055
 0.09
chr22_37680309_37680627 0.57 CYTH4
 cytohesin 4
 1940
 0.3
chr4_109028345_109028496 0.56 LEF1
 lymphoid enhancer-binding factor 1
 59037
 0.12
chr22_40324201_40324352 0.56 GRAP2
 GRB2-related adaptor protein 2
 1635
 0.36
chr7_142131561_142131712 0.55 PRSS3P3
 protease, serine, 3 pseudogene 3
 142027
 0.04
chr12_111868224_111868441 0.55 SH2B3
 SH2B adaptor protein 3
 4334
 0.21
chr16_84631467_84631681 0.54 RP11-61F12.1
3575
 0.21
chr14_23015461_23015710 0.54 AE000662.92
 Uncharacterized protein
 9949
 0.11
chr20_57722405_57722705 0.54 ZNF831
 zinc finger protein 831
 43520
 0.15
chr7_2550958_2551215 0.52 LFNG
 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
 1077
 0.47
chr1_173988808_173989095 0.51 RC3H1
 ring finger and CCCH-type domains 1
 2484
 0.25
chr7_142168431_142168627 0.50 PRSS3P3
 protease, serine, 3 pseudogene 3
 178920
 0.03
chr12_32115176_32115327 0.50 KIAA1551
 KIAA1551
 172
 0.96
chr7_100148187_100148338 0.50 AGFG2
 ArfGAP with FG repeats 2
 5028
 0.1
chr1_66801255_66801864 0.49 PDE4B
 phosphodiesterase 4B, cAMP-specific
 3687
 0.36
chr1_200856869_200857106 0.48 C1orf106
 chromosome 1 open reading frame 106
 3189
 0.23
chr1_23945436_23945655 0.48 MDS2
 myelodysplastic syndrome 2 translocation associated
 8279
 0.19
chr9_130734573_130734730 0.47 FAM102A
 family with sequence similarity 102, member A
 8141
 0.11
chr13_50203416_50203569 0.47 ARL11
 ADP-ribosylation factor-like 11
 1057
 0.56
chr1_160680158_160680309 0.47 CD48
 CD48 molecule
 1360
 0.38
chr11_65184608_65185159 0.47 ENSG00000245532
 .
 27046
 0.09
chr3_171175125_171175276 0.46 TNIK
 TRAF2 and NCK interacting kinase
 2652
 0.31
chr5_81147265_81147701 0.46 SSBP2
 single-stranded DNA binding protein 2
 100411
 0.07
chr4_186177003_186177154 0.46 SNX25
 sorting nexin 25
 45845
 0.12
chr19_54881402_54882266 0.46 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 224
 0.88
chr3_50606285_50606482 0.45 HEMK1
 HemK methyltransferase family member 1
 200
 0.89
chr12_7068434_7068709 0.45 ENSG00000207713
 .
 4291
 0.07
chr11_1876733_1876884 0.45 LSP1
 lymphocyte-specific protein 1
 2608
 0.14
chr5_149791833_149792018 0.44 CD74
 CD74 molecule, major histocompatibility complex, class II invariant chain
 370
 0.85
chr16_88701814_88701965 0.44 IL17C
 interleukin 17C
 3112
 0.13
chr15_81594027_81594306 0.43 IL16
 interleukin 16
 2409
 0.29
chr2_429621_429920 0.43 FAM150B
 family with sequence similarity 150, member B
 140919
 0.04
chr4_143298422_143298705 0.43 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 53849
 0.19
chr12_62658631_62659028 0.43 USP15
 ubiquitin specific peptidase 15
 4620
 0.23
chr20_30639443_30639594 0.43 HCK
 hemopoietic cell kinase
 473
 0.64
chr2_68995092_68995259 0.43 ARHGAP25
 Rho GTPase activating protein 25
 6758
 0.26
chr1_110046634_110046785 0.42 AMIGO1
 adhesion molecule with Ig-like domain 1
 5595
 0.11
chr6_159088530_159088681 0.41 SYTL3
 synaptotagmin-like 3
 4410
 0.22
chrX_128913998_128914362 0.41 SASH3
 SAM and SH3 domain containing 3
 220
 0.94
chr3_141516104_141516959 0.41 ENSG00000265391
 .
 9778
 0.19
chr19_54880943_54881230 0.40 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 972
 0.39
chr1_111739082_111739233 0.40 DENND2D
 DENN/MADD domain containing 2D
 4154
 0.14
chr5_159897528_159897679 0.40 ENSG00000265237
 .
 3806
 0.2
chr14_22970547_22970698 0.40 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 14451
 0.1
chr15_38851437_38851588 0.38 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 771
 0.65
chr7_142111441_142111592 0.37 PRSS3P3
 protease, serine, 3 pseudogene 3
 121907
 0.05
chr12_51717169_51717830 0.37 BIN2
 bridging integrator 2
 400
 0.82
chr9_102972035_102972186 0.37 ENSG00000239908
 .
 107269
 0.06
chrX_24482692_24483178 0.36 PDK3
 pyruvate dehydrogenase kinase, isozyme 3
 403
 0.88
chr2_198169566_198169717 0.36 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 2398
 0.25
chr15_86127976_86128183 0.36 RP11-815J21.2
4670
 0.2
chr1_14026152_14026644 0.36 PRDM2
 PR domain containing 2, with ZNF domain
 295
 0.9
chr8_67592155_67592325 0.36 C8orf44
 chromosome 8 open reading frame 44
 3786
 0.17
chr4_6911822_6912351 0.35 TBC1D14
 TBC1 domain family, member 14
 111
 0.97
chr7_624041_624192 0.35 PRKAR1B
 protein kinase, cAMP-dependent, regulatory, type I, beta
 18204
 0.15
chr12_57873508_57873659 0.35 ARHGAP9
 Rho GTPase activating protein 9
 50
 0.94
chr6_139458867_139459205 0.35 HECA
 headcase homolog (Drosophila)
 2787
 0.35
chr9_131998413_131998748 0.35 ENSG00000220992
 .
 5584
 0.18
chr6_30798000_30798388 0.35 ENSG00000202241
 .
 33833
 0.07
chr7_50417947_50418099 0.34 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 50778
 0.15
chr2_68964714_68964948 0.34 ARHGAP25
 Rho GTPase activating protein 25
 2817
 0.35
chr17_78992429_78992643 0.34 AC127496.1
 Uncharacterized protein
 15401
 0.11
chr11_413234_413456 0.34 SIGIRR
 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
 1603
 0.21
chr3_48520203_48520354 0.34 SHISA5
 shisa family member 5
 5661
 0.1
chr17_62833435_62833598 0.34 PLEKHM1P
 pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
 273
 0.86
chr12_27094718_27094869 0.34 FGFR1OP2
 FGFR1 oncogene partner 2
 3360
 0.19
chr11_104914891_104915295 0.34 CARD16
 caspase recruitment domain family, member 16
 941
 0.54
chr8_41680168_41680319 0.34 ENSG00000241834
 .
 17614
 0.17
chr4_140357401_140357552 0.34 ENSG00000239005
 .
 172
 0.94
chr10_134364208_134364359 0.34 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 12640
 0.21
chr11_104941226_104941560 0.34 CARD16
 caspase recruitment domain family, member 16
 25290
 0.15
chr9_140210185_140210336 0.34 NRARP
 NOTCH-regulated ankyrin repeat protein
 13557
 0.09
chr12_113279832_113279983 0.34 RPH3A
 rabphilin 3A homolog (mouse)
 13783
 0.23
chrX_39954398_39954982 0.33 BCOR
 BCL6 corepressor
 1966
 0.49
chr2_173327465_173327877 0.33 AC078883.3
3069
 0.24
chr14_96592631_96592782 0.33 ENSG00000221236
 .
 10482
 0.18
chr2_27072177_27072340 0.33 DPYSL5
 dihydropyrimidinase-like 5
 882
 0.61
chr1_31226735_31227120 0.33 LAPTM5
 lysosomal protein transmembrane 5
 3740
 0.2
chr15_67834334_67834863 0.32 MAP2K5
 mitogen-activated protein kinase kinase 5
 449
 0.86
chr14_22320809_22320960 0.32 ENSG00000222776
 .
 72099
 0.11
chr13_41068422_41068589 0.32 AL133318.1
 Uncharacterized protein
 42818
 0.18
chr1_156024631_156024876 0.32 LAMTOR2
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
 112
 0.9
chr21_36341148_36341299 0.32 RUNX1
 runt-related transcription factor 1
 79136
 0.12
chr11_68519110_68519316 0.32 MTL5
 metallothionein-like 5, testis-specific (tesmin)
 181
 0.96
chr11_67042666_67042837 0.32 ADRBK1
 adrenergic, beta, receptor kinase 1
 8799
 0.11
chr13_20438059_20438616 0.32 ZMYM5
 zinc finger, MYM-type 5
 561
 0.73
chr1_26872331_26872899 0.32 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
 272
 0.88
chr11_6766362_6766695 0.32 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 23417
 0.11
chrX_154493319_154493834 0.31 RAB39B
 RAB39B, member RAS oncogene family
 298
 0.9
chr7_63360438_63360674 0.31 ENSG00000263891
 .
 890
 0.66
chr16_68113803_68114150 0.31 NFATC3
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 5271
 0.12
chr1_9789192_9789343 0.31 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 11140
 0.17
chr11_104904746_104905919 0.31 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 508
 0.77
chr14_64974613_64974785 0.31 ZBTB25
 zinc finger and BTB domain containing 25
 2768
 0.16
chr4_100738015_100738341 0.31 DAPP1
 dual adaptor of phosphotyrosine and 3-phosphoinositides
 175
 0.97
chr6_33312984_33313135 0.31 DAXX
 death-domain associated protein
 16046
 0.09
chr1_161038546_161039545 0.31 ARHGAP30
 Rho GTPase activating protein 30
 411
 0.65
chr9_117152254_117152405 0.31 AKNA
 AT-hook transcription factor
 1968
 0.35
chr19_51945391_51945555 0.31 SIGLEC8
 sialic acid binding Ig-like lectin 8
 16233
 0.08
chr11_67173386_67173537 0.31 TBC1D10C
 TBC1 domain family, member 10C
 1801
 0.14
chr1_6524907_6525205 0.30 TNFRSF25
 tumor necrosis factor receptor superfamily, member 25
 634
 0.58
chr19_38924431_38924659 0.30 RYR1
 ryanodine receptor 1 (skeletal)
 75
 0.95
chr16_23847524_23848074 0.30 PRKCB
 protein kinase C, beta
 396
 0.89
chr16_17445443_17445594 0.30 XYLT1
 xylosyltransferase I
 119220
 0.07
chr11_64509794_64509966 0.30 RASGRP2
 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
 529
 0.68
chr8_6132048_6132199 0.30 RP11-115C21.2
131940
 0.05
chr19_55895651_55896024 0.30 TMEM238
 transmembrane protein 238
 129
 0.85
chr10_11602391_11602542 0.30 USP6NL
 USP6 N-terminal like
 13270
 0.25
chr11_128548299_128548450 0.30 RP11-744N12.3
7949
 0.19
chr16_28204661_28205336 0.30 ENSG00000200138
 .
 10359
 0.17
chr9_134147000_134147362 0.30 FAM78A
 family with sequence similarity 78, member A
 1271
 0.44
chr6_162270529_162270680 0.29 ENSG00000221021
 .
 234506
 0.02
chr1_150849308_150849506 0.29 ARNT
 aryl hydrocarbon receptor nuclear translocator
 163
 0.93
chr1_3087882_3088114 0.29 RP1-163G9.2
37725
 0.18
chr17_66083661_66083812 0.29 LINC00674
 long intergenic non-protein coding RNA 674
 14313
 0.19
chr8_141608249_141608648 0.29 AGO2
 argonaute RISC catalytic component 2
 7539
 0.25
chr1_204776059_204776226 0.29 NFASC
 neurofascin
 21640
 0.2
chr19_43033005_43033156 0.29 CEACAM1
 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
 419
 0.83
chr1_192777377_192777993 0.28 RGS2
 regulator of G-protein signaling 2, 24kDa
 486
 0.87
chr3_50656380_50656531 0.28 MAPKAPK3
 mitogen-activated protein kinase-activated protein kinase 3
 1634
 0.31
chr10_3827872_3828413 0.28 KLF6
 Kruppel-like factor 6
 669
 0.75
chr1_31229648_31230364 0.28 LAPTM5
 lysosomal protein transmembrane 5
 661
 0.67
chr19_48827788_48827939 0.28 EMP3
 epithelial membrane protein 3
 719
 0.53
chr17_28845537_28845688 0.28 TBC1D29
 TBC1 domain family, member 29
 38518
 0.11
chr1_27669467_27669709 0.28 SYTL1
 synaptotagmin-like 1
 131
 0.93
chr2_136874741_136875309 0.28 CXCR4
 chemokine (C-X-C motif) receptor 4
 710
 0.79
chr3_56956069_56956429 0.28 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 5750
 0.25
chr21_37802462_37802613 0.27 AP000695.6
121
 0.95
chr6_32158925_32159076 0.27 PBX2
 pre-B-cell leukemia homeobox 2
 1037
 0.26
chr8_22297680_22297831 0.27 PPP3CC
 protein phosphatase 3, catalytic subunit, gamma isozyme
 577
 0.7
chr16_17107310_17107606 0.27 CTD-2576D5.4
120903
 0.07
chr9_44402497_44402689 0.27 BX088651.1
 LOC100126582 protein; Uncharacterized protein
 166
 0.97
chr11_3881667_3881833 0.27 STIM1
 stromal interaction molecule 1
 4338
 0.12
chr2_127534428_127534987 0.27 ENSG00000206963
 .
 74189
 0.11
chr6_135518740_135518891 0.27 MYB-AS1
 MYB antisense RNA 1
 1682
 0.35
chr1_225655628_225655947 0.27 RP11-496N12.6
2742
 0.3
chr12_104854827_104855220 0.27 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 4244
 0.32
chr1_11968429_11968611 0.27 ENSG00000199347
 .
 311
 0.79
chrX_70330282_70330478 0.27 IL2RG
 interleukin 2 receptor, gamma
 368
 0.76
chr7_100411698_100411849 0.27 ENSG00000263672
 .
 7113
 0.11
chr9_34178665_34178872 0.26 UBAP1
 ubiquitin associated protein 1
 235
 0.91
chr1_235148192_235148405 0.26 ENSG00000239690
 .
 108365
 0.06
chr8_19615003_19615576 0.26 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 93
 0.98
chr21_45773621_45773812 0.26 TRPM2
 transient receptor potential cation channel, subfamily M, member 2
 145
 0.91
chr1_151131769_151131920 0.26 SCNM1
 sodium channel modifier 1
 2704
 0.12
chr7_150725843_150726078 0.26 ABCB8
 ATP-binding cassette, sub-family B (MDR/TAP), member 8
 406
 0.6
chr6_35270264_35270539 0.26 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 4772
 0.2
chr9_123342586_123342893 0.26 CDK5RAP2
 CDK5 regulatory subunit associated protein 2
 302
 0.94
chr16_2975177_2975328 0.26 FLYWCH1
 FLYWCH-type zinc finger 1
 5546
 0.1
chr14_91866607_91866949 0.26 CCDC88C
 coiled-coil domain containing 88C
 16912
 0.22
chr1_226900274_226900494 0.26 ITPKB
 inositol-trisphosphate 3-kinase B
 24775
 0.18
chr19_49362364_49362642 0.26 PLEKHA4
 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
 128
 0.91
chr19_45195617_45195899 0.26 CEACAM16
 carcinoembryonic antigen-related cell adhesion molecule 16
 6663
 0.12
chr17_76164152_76164326 0.26 SYNGR2
 synaptogyrin 2
 400
 0.75
chr6_152492444_152492671 0.26 SYNE1
 spectrin repeat containing, nuclear envelope 1
 3058
 0.39
chr11_118755323_118755474 0.26 CXCR5
 chemokine (C-X-C motif) receptor 5
 923
 0.38
chrX_69673823_69673974 0.26 DLG3
 discs, large homolog 3 (Drosophila)
 1048
 0.39
chr17_6659044_6659287 0.26 XAF1
 XIAP associated factor 1
 6
 0.97
chr9_132803803_132804674 0.25 FNBP1
 formin binding protein 1
 1203
 0.49
chr6_2222017_2222664 0.25 GMDS
 GDP-mannose 4,6-dehydratase
 23586
 0.28
chr1_185125818_185126183 0.25 TRMT1L
 tRNA methyltransferase 1 homolog (S. cerevisiae)-like
 113
 0.64
chr1_169673693_169673844 0.25 SELL
 selectin L
 7071
 0.2
chr5_175085682_175085863 0.25 HRH2
 histamine receptor H2
 739
 0.7
chr5_82835664_82835815 0.25 VCAN-AS1
 VCAN antisense RNA 1
 22394
 0.23
chr11_67234655_67234806 0.25 TMEM134
 transmembrane protein 134
 1974
 0.13
chr9_46844398_46844609 0.25 RP11-111F5.5
100326
 0.08
chr17_79212373_79212815 0.25 ENTHD2
 ENTH domain containing 2
 261
 0.63
chr17_25622078_25622646 0.25 WSB1
 WD repeat and SOCS box containing 1
 990
 0.48
chr14_56604101_56604314 0.25 PELI2
 pellino E3 ubiquitin protein ligase family member 2
 18380
 0.24
chr3_107941997_107942148 0.25 IFT57
 intraflagellar transport 57 homolog (Chlamydomonas)
 655
 0.8
chr2_118771851_118772310 0.25 CCDC93
 coiled-coil domain containing 93
 371
 0.79
chr12_57870819_57871184 0.25 ARHGAP9
 Rho GTPase activating protein 9
 566
 0.53
chr4_38664253_38665008 0.24 KLF3
 Kruppel-like factor 3 (basic)
 1187
 0.34
chr12_106696333_106697091 0.24 TCP11L2
 t-complex 11, testis-specific-like 2
 101
 0.95
chr2_149684444_149684807 0.24 ENSG00000263656
 .
 35178
 0.16
chr14_22749370_22749521 0.24 ENSG00000238634
 .
 138558
 0.04
chr17_4615230_4615381 0.24 ARRB2
 arrestin, beta 2
 1311
 0.23
chr19_10449910_10450285 0.24 ICAM3
 intercellular adhesion molecule 3
 198
 0.86
chr19_16229742_16229926 0.24 RAB8A
 RAB8A, member RAS oncogene family
 7127
 0.13
chr12_122230087_122230336 0.24 RHOF
 ras homolog family member F (in filopodia)
 1055
 0.48

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of NR1H4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0002295 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.2 0.5 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.2 0.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.7 GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 0.5 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.1 0.3 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.4 GO:0046398 UDP-glucuronate metabolic process(GO:0046398)
0.1 0.4 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.1 0.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1 0.2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 0.2 GO:0007132 meiotic metaphase I(GO:0007132)
0.1 0.3 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.1 0.3 GO:1903313 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.1 0.7 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.1 GO:0002448 mast cell mediated immunity(GO:0002448)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.2 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537)
0.1 0.5 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.0 0.2 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.1 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0051136 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0045990 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.2 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911) negative regulation of cell killing(GO:0031342)
0.0 0.2 GO:0002507 tolerance induction(GO:0002507)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.0 0.2 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0001787 natural killer cell proliferation(GO:0001787) NK T cell activation(GO:0051132)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0002467 germinal center formation(GO:0002467)
0.0 0.1 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.0 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.1 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0052251 induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0 0.0 GO:0046348 amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0002707 negative regulation of lymphocyte mediated immunity(GO:0002707)
0.0 0.2 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0 0.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.1 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0048535 lymph node development(GO:0048535)
0.0 0.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.1 GO:0000239 pachytene(GO:0000239)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.1 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.0 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.0 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.1 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:0002839 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.1 GO:0070265 necrotic cell death(GO:0070265)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.6 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.0 GO:0060197 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.1 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0050854 regulation of antigen receptor-mediated signaling pathway(GO:0050854)
0.0 0.2 GO:0006929 substrate-dependent cell migration(GO:0006929)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.0 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.8 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0031000 response to caffeine(GO:0031000)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.0 GO:0051323 metaphase(GO:0051323)
0.0 0.1 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.0 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.1 GO:0090151 protein import into mitochondrial inner membrane(GO:0045039) establishment of protein localization to mitochondrial membrane(GO:0090151)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.1 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.0 GO:2000380 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.0 GO:0033158 regulation of protein import into nucleus, translocation(GO:0033158)
0.0 0.1 GO:1903393 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.2 GO:0008633 obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0 0.0 GO:0097502 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.0 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.7 GO:0034138 toll-like receptor 3 signaling pathway(GO:0034138)
0.0 0.0 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.0 GO:0034143 regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.0 0.0 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 0.0 GO:0032747 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.0 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.1 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.1 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0046968 peptide antigen transport(GO:0046968)
0.0 0.1 GO:0060761 negative regulation of response to cytokine stimulus(GO:0060761)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.2 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.1 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.0 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.0 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.0 GO:0045588 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.2 GO:0035137 hindlimb morphogenesis(GO:0035137)
0.0 0.2 GO:0042102 positive regulation of T cell proliferation(GO:0042102)
0.0 0.3 GO:0051607 defense response to virus(GO:0051607)
0.0 0.0 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.9 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.0 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.0 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.6 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.0 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.0 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.0 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.0 GO:0097191 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.0 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.0 GO:0002335 mature B cell differentiation involved in immune response(GO:0002313) mature B cell differentiation(GO:0002335)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.0 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.0 GO:0070602 centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.0 GO:0051657 maintenance of organelle location(GO:0051657)
0.0 0.2 GO:1901185 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0 0.0 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.0 GO:2000909 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.0 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.0 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.0 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.0 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812)
0.0 0.8 GO:0070489 T cell activation(GO:0042110) leukocyte aggregation(GO:0070486) T cell aggregation(GO:0070489) lymphocyte aggregation(GO:0071593)
0.0 0.0 GO:1904181 positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.1 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.6 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1 0.3 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.2 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.1 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.0 GO:0033185 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.0 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.2 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.6 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.3 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.2 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.3 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.5 GO:0005522 profilin binding(GO:0005522)
0.1 0.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 0.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 0.2 GO:0043495 protein anchor(GO:0043495)
0.1 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.8 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.0 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 1.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.0 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.0 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.0 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.0 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.0 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.0 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.7 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.1 GO:0031593 polyubiquitin binding(GO:0031593)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.1 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.2 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.1 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 0.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 0.5 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.0 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.5 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.0 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.1 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.3 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.0 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.0 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway