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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NR2F1

Z-value: 1.05

Motif logo

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Transcription factors associated with NR2F1

Gene Symbol Gene ID Gene Info
NR2F1
ENSG00000175745.7 NR2F1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
NR2F1chr5_92919252_929194032840.899493-0.196.2e-01Click!
NR2F1chr5_92918344_929190043690.842576-0.098.2e-01Click!
NR2F1chr5_92919468_929198466140.6922940.029.6e-01Click!
NR2F1chr5_92918170_929183217980.536761-0.019.8e-01Click!

Activity of the NR2F1 motif across conditions

Conditions sorted by the z-value of the NR2F1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_112123532_112123887 0.43 SMNDC1
 survival motor neuron domain containing 1
 59000
 0.12
chr22_39639623_39639926 0.41 PDGFB
 platelet-derived growth factor beta polypeptide
 753
 0.58
chr11_65324607_65325239 0.32 LTBP3
 latent transforming growth factor beta binding protein 3
 313
 0.76
chr10_99441863_99442014 0.28 AVPI1
 arginine vasopressin-induced 1
 5142
 0.16
chr12_56327336_56327517 0.28 WIBG
 within bgcn homolog (Drosophila)
 1024
 0.3
chr13_114543321_114543472 0.28 GAS6
 growth arrest-specific 6
 4379
 0.26
chr1_215550174_215550325 0.26 KCTD3
 potassium channel tetramerization domain containing 3
 190486
 0.03
chr7_150435640_150435791 0.26 GIMAP5
 GTPase, IMAP family member 5
 1279
 0.41
chr19_17797231_17797557 0.25 UNC13A
 unc-13 homolog A (C. elegans)
 1614
 0.31
chr12_6711834_6712315 0.25 CHD4
 chromodomain helicase DNA binding protein 4
 3772
 0.1
chr12_24691177_24691328 0.24 ENSG00000240481
 .
 168470
 0.04
chr9_130740055_130740787 0.24 FAM102A
 family with sequence similarity 102, member A
 2371
 0.18
chr2_42599068_42599219 0.24 COX7A2L
 cytochrome c oxidase subunit VIIa polypeptide 2 like
 2993
 0.32
chr22_45065479_45065630 0.24 PRR5
 proline rich 5 (renal)
 961
 0.61
chr10_77873536_77873687 0.23 ENSG00000221232
 .
 13458
 0.28
chr6_170493106_170493257 0.23 RP11-302L19.1
15440
 0.24
chr11_64073389_64074392 0.23 ESRRA
 estrogen-related receptor alpha
 28
 0.92
chrX_56829451_56830094 0.22 ENSG00000204272
 .
 74080
 0.12
chr6_151701170_151702048 0.22 ENSG00000252615
 .
 2375
 0.22
chr12_663051_663343 0.22 B4GALNT3
 beta-1,4-N-acetyl-galactosaminyl transferase 3
 10898
 0.16
chr14_22997122_22997273 0.22 TRAJ15
 T cell receptor alpha joining 15
 1383
 0.28
chr19_18304075_18305119 0.22 MPV17L2
 MPV17 mitochondrial membrane protein-like 2
 605
 0.57
chr20_62369505_62369786 0.22 RP4-583P15.14
22
 0.92
chr4_143323082_143323233 0.22 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 29255
 0.27
chr19_1466791_1467069 0.22 ENSG00000267317
 .
 4166
 0.08
chr16_28997666_28997863 0.21 LAT
 linker for activation of T cells
 231
 0.83
chr22_31033767_31033918 0.21 SLC35E4
 solute carrier family 35, member E4
 1332
 0.32
chr3_132377366_132377517 0.21 UBA5
 ubiquitin-like modifier activating enzyme 5
 869
 0.47
chr4_7972052_7972961 0.21 AFAP1
 actin filament associated protein 1
 30853
 0.14
chr3_97591824_97591975 0.21 CRYBG3
 beta-gamma crystallin domain containing 3
 3920
 0.3
chr12_8190824_8190975 0.21 FOXJ2
 forkhead box J2
 4943
 0.17
chr5_67564084_67564251 0.21 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 11901
 0.28
chr20_30873595_30873746 0.21 ENSG00000264308
 .
 8079
 0.16
chr2_19073151_19073433 0.21 NT5C1B
 5'-nucleotidase, cytosolic IB
 302454
 0.01
chr11_101987791_101987942 0.20 YAP1
 Yes-associated protein 1
 4621
 0.19
chr19_48222929_48223134 0.20 EHD2
 EH-domain containing 2
 6352
 0.14
chr11_122722660_122722811 0.20 CRTAM
 cytotoxic and regulatory T cell molecule
 10276
 0.21
chr11_118788335_118788931 0.20 BCL9L
 B-cell CLL/lymphoma 9-like
 980
 0.33
chr3_124770412_124771279 0.20 HEG1
 heart development protein with EGF-like domains 1
 3957
 0.22
chr1_25944952_25945229 0.20 MAN1C1
 mannosidase, alpha, class 1C, member 1
 749
 0.68
chr8_145010856_145011411 0.20 PLEC
 plectin
 2625
 0.16
chr11_71750284_71750541 0.20 NUMA1
 nuclear mitotic apparatus protein 1
 459
 0.68
chr9_136238609_136239100 0.19 SURF4
 surfeit 4
 4060
 0.08
chr14_52687906_52688082 0.19 PTGDR
 prostaglandin D2 receptor (DP)
 46437
 0.16
chr3_194117300_194117501 0.19 GP5
 glycoprotein V (platelet)
 1683
 0.34
chr1_17914943_17915229 0.19 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 175
 0.97
chr10_43761610_43761802 0.19 RASGEF1A
 RasGEF domain family, member 1A
 661
 0.77
chr7_25013883_25014034 0.19 OSBPL3
 oxysterol binding protein-like 3
 5802
 0.3
chr4_188524057_188524208 0.19 ZFP42
 ZFP42 zinc finger protein
 392793
 0.01
chr17_77022963_77023114 0.19 C1QTNF1-AS1
 C1QTNF1 antisense RNA 1
 645
 0.56
chr12_47615454_47615605 0.18 PCED1B
 PC-esterase domain containing 1B
 1755
 0.4
chr12_54132562_54132781 0.18 CALCOCO1
 calcium binding and coiled-coil domain 1
 11142
 0.17
chr3_171175410_171175561 0.18 TNIK
 TRAF2 and NCK interacting kinase
 2367
 0.33
chr15_31622749_31622975 0.18 KLF13
 Kruppel-like factor 13
 3804
 0.36
chr5_9762754_9762905 0.18 ENSG00000222054
 .
 1810
 0.44
chr1_12675825_12676469 0.18 DHRS3
 dehydrogenase/reductase (SDR family) member 3
 1590
 0.37
chr19_18898403_18898596 0.18 COMP
 cartilage oligomeric matrix protein
 3615
 0.19
chr2_158296405_158296556 0.18 CYTIP
 cytohesin 1 interacting protein
 554
 0.73
chr3_124762287_124762438 0.18 HEG1
 heart development protein with EGF-like domains 1
 12440
 0.18
chr9_132428871_132429094 0.18 PRRX2
 paired related homeobox 2
 1062
 0.42
chr6_119669093_119669825 0.18 MAN1A1
 mannosidase, alpha, class 1A, member 1
 1442
 0.51
chr14_103560765_103560916 0.18 RP11-736N17.8
220
 0.92
chr5_35813662_35813813 0.18 CTD-2113L7.1
13383
 0.2
chr18_3411935_3412439 0.18 TGIF1
 TGFB-induced factor homeobox 1
 115
 0.97
chr11_118212224_118212431 0.18 CD3D
 CD3d molecule, delta (CD3-TCR complex)
 675
 0.54
chr10_6094124_6094387 0.17 IL2RA
 interleukin 2 receptor, alpha
 9998
 0.15
chr10_8099034_8099185 0.17 GATA3
 GATA binding protein 3
 2340
 0.45
chr14_98443402_98443682 0.17 C14orf64
 chromosome 14 open reading frame 64
 841
 0.77
chr9_130738670_130738821 0.17 FAM102A
 family with sequence similarity 102, member A
 4047
 0.14
chr5_172246747_172246898 0.17 ERGIC1
 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
 14456
 0.16
chr6_170189987_170191002 0.17 RP1-266L20.9
19985
 0.14
chr16_10713819_10713970 0.17 EMP2
 epithelial membrane protein 2
 39339
 0.13
chr14_99729436_99729607 0.17 AL109767.1
236
 0.94
chr6_26614195_26614680 0.17 ABT1
 activator of basal transcription 1
 17257
 0.17
chr6_143247533_143248138 0.17 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 18503
 0.25
chr5_133446419_133446570 0.17 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 3908
 0.27
chr19_1470719_1471158 0.16 C19orf25
 chromosome 19 open reading frame 25
 7958
 0.07
chr20_17831337_17831488 0.16 ENSG00000221220
 .
 8185
 0.22
chr12_45269258_45270040 0.16 NELL2
 NEL-like 2 (chicken)
 54
 0.98
chr9_137967884_137968035 0.16 OLFM1
 olfactomedin 1
 447
 0.88
chr4_38080893_38081044 0.16 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
 33476
 0.22
chr2_44844069_44844220 0.16 ENSG00000252896
 .
 165125
 0.04
chr16_87520451_87520724 0.16 ZCCHC14
 zinc finger, CCHC domain containing 14
 5064
 0.23
chr10_33405368_33405626 0.16 ENSG00000263576
 .
 17933
 0.22
chr3_64207181_64207332 0.16 PRICKLE2
 prickle homolog 2 (Drosophila)
 3875
 0.26
chr1_189407105_189407256 0.16 ENSG00000252553
 .
 228206
 0.02
chr14_105953334_105954468 0.16 CRIP1
 cysteine-rich protein 1 (intestinal)
 647
 0.53
chr4_89518835_89518986 0.16 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 4381
 0.2
chr11_66090538_66090689 0.16 CD248
 CD248 molecule, endosialin
 6098
 0.07
chr18_56105832_56106078 0.16 ENSG00000207778
 .
 12351
 0.17
chr22_47428996_47429147 0.15 ENSG00000221672
 .
 185268
 0.03
chr9_79018493_79018995 0.15 RFK
 riboflavin kinase
 9323
 0.24
chr11_16118588_16118739 0.15 ENSG00000221556
 .
 27199
 0.24
chr3_53033553_53033704 0.15 SFMBT1
 Scm-like with four mbt domains 1
 45653
 0.12
chr2_181971569_181971726 0.15 UBE2E3
 ubiquitin-conjugating enzyme E2E 3
 124897
 0.06
chr10_134351637_134352716 0.15 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 533
 0.8
chr2_230195712_230195863 0.15 PID1
 phosphotyrosine interaction domain containing 1
 59786
 0.15
chr8_66751756_66751954 0.15 PDE7A
 phosphodiesterase 7A
 872
 0.73
chr8_111917370_111917521 0.15 KCNV1
 potassium channel, subfamily V, member 1
 929369
 0.0
chr14_76447085_76447352 0.15 TGFB3
 transforming growth factor, beta 3
 118
 0.97
chr3_48630851_48631002 0.15 COL7A1
 collagen, type VII, alpha 1
 1667
 0.2
chr19_48221689_48221840 0.15 EHD2
 EH-domain containing 2
 5085
 0.15
chr3_69888019_69888170 0.15 MITF
 microphthalmia-associated transcription factor
 27269
 0.22
chr4_157720406_157720557 0.15 RP11-154F14.2
42030
 0.17
chr4_87763331_87763482 0.15 SLC10A6
 solute carrier family 10 (sodium/bile acid cotransporter), member 6
 7010
 0.26
chr21_30257999_30258150 0.15 N6AMT1
 N-6 adenine-specific DNA methyltransferase 1 (putative)
 381
 0.9
chr8_132052704_132052867 0.15 ADCY8
 adenylate cyclase 8 (brain)
 206
 0.97
chr6_56010689_56010840 0.15 COL21A1
 collagen, type XXI, alpha 1
 20971
 0.28
chr20_821653_822360 0.15 FAM110A
 family with sequence similarity 110, member A
 3279
 0.3
chr11_63304045_63305245 0.14 RARRES3
 retinoic acid receptor responder (tazarotene induced) 3
 352
 0.84
chr12_111177324_111178139 0.14 PPP1CC
 protein phosphatase 1, catalytic subunit, gamma isozyme
 2913
 0.28
chr22_41798411_41798579 0.14 TEF
 thyrotrophic embryonic factor
 19556
 0.13
chr11_128336036_128336187 0.14 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 39178
 0.19
chr7_75622595_75622746 0.14 POR
 P450 (cytochrome) oxidoreductase
 11441
 0.16
chr13_76334947_76335146 0.14 LMO7
 LIM domain 7
 249
 0.95
chr12_94441024_94441175 0.14 ENSG00000223126
 .
 38276
 0.18
chr2_55361422_55361625 0.14 RTN4
 reticulon 4
 21766
 0.16
chr11_46268403_46268554 0.14 CTD-2589M5.4
27620
 0.16
chr3_138952873_138953024 0.14 MRPS22
 mitochondrial ribosomal protein S22
 109913
 0.06
chr7_129546585_129546878 0.14 UBE2H
 ubiquitin-conjugating enzyme E2H
 44436
 0.1
chr11_46370356_46370605 0.14 DGKZ
 diacylglycerol kinase, zeta
 1342
 0.36
chr1_207090442_207090593 0.14 FAIM3
 Fas apoptotic inhibitory molecule 3
 4695
 0.16
chr19_2503722_2503936 0.14 ENSG00000252962
 .
 690
 0.64
chr13_43406909_43407060 0.14 FAM216B
 family with sequence similarity 216, member B
 51233
 0.18
chr1_28385802_28385953 0.14 EYA3
 eyes absent homolog 3 (Drosophila)
 1279
 0.41
chr18_52968140_52968291 0.14 TCF4
 transcription factor 4
 1642
 0.52
chr1_156091493_156091688 0.14 LMNA
 lamin A/C
 4361
 0.13
chr7_157405294_157405606 0.14 AC005481.5
 Uncharacterized protein
 1265
 0.52
chr17_15151294_15151445 0.14 ENSG00000265110
 .
 3644
 0.18
chr9_21611364_21611515 0.14 MIR31HG
 MIR31 host gene (non-protein coding)
 51771
 0.12
chr4_150608043_150608194 0.14 ENSG00000202331
 .
 220594
 0.02
chr2_231090336_231091061 0.14 SP140
 SP140 nuclear body protein
 219
 0.54
chr15_83348879_83349094 0.14 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
 19006
 0.12
chr3_150014037_150014188 0.14 TSC22D2
 TSC22 domain family, member 2
 112010
 0.06
chr3_195839047_195839198 0.14 TFRC
 transferrin receptor
 30062
 0.14
chr3_156561383_156561569 0.14 LEKR1
 leucine, glutamate and lysine rich 1
 17328
 0.27
chr11_85538689_85538889 0.13 SYTL2
 synaptotagmin-like 2
 16605
 0.17
chrY_14617944_14618095 0.13 GYG2P1
 glycogenin 2 pseudogene 1
 85898
 0.1
chr5_37303368_37303519 0.13 ENSG00000251880
 .
 23794
 0.18
chr3_53184243_53184394 0.13 PRKCD
 protein kinase C, delta
 5707
 0.19
chr3_30655384_30655643 0.13 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 7420
 0.31
chr1_113050352_113050503 0.13 WNT2B
 wingless-type MMTV integration site family, member 2B
 973
 0.56
chr17_46618647_46619025 0.13 HOXB-AS1
 HOXB cluster antisense RNA 1
 2077
 0.14
chr3_131220949_131221185 0.13 MRPL3
 mitochondrial ribosomal protein L3
 714
 0.66
chr2_131582424_131582575 0.13 AC133785.1
12068
 0.16
chr7_44185996_44186184 0.13 GCK
 glucokinase (hexokinase 4)
 347
 0.78
chr13_34061518_34061669 0.13 STARD13
 StAR-related lipid transfer (START) domain containing 13
 136826
 0.05
chr1_228073244_228073456 0.13 ENSG00000264483
 .
 56034
 0.1
chr3_86997346_86997497 0.13 VGLL3
 vestigial like 3 (Drosophila)
 42431
 0.22
chr10_32215556_32215707 0.13 ARHGAP12
 Rho GTPase activating protein 12
 2097
 0.41
chr3_15403025_15403378 0.13 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 20326
 0.13
chr1_236222466_236222646 0.13 ENSG00000252822
 .
 1421
 0.44
chr17_27892819_27893926 0.13 ABHD15
 abhydrolase domain containing 15
 783
 0.31
chr15_96725215_96725403 0.13 NR2F2-AS1
 NR2F2 antisense RNA 1
 40975
 0.19
chr2_110872434_110873339 0.13 MALL
 mal, T-cell differentiation protein-like
 713
 0.63
chr19_43969380_43969688 0.13 LYPD3
 LY6/PLAUR domain containing 3
 278
 0.87
chr11_62169601_62169752 0.13 SCGB1A1
 secretoglobin, family 1A, member 1 (uteroglobin)
 2899
 0.16
chr1_45273651_45274047 0.13 BTBD19
 BTB (POZ) domain containing 19
 305
 0.68
chr14_22849167_22849401 0.13 ENSG00000251002
 .
 52435
 0.09
chr6_143227809_143227960 0.13 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 38454
 0.19
chr1_208000240_208000391 0.13 ENSG00000203709
 .
 24447
 0.21
chr5_118503926_118504077 0.13 ENSG00000264536
 .
 13669
 0.18
chr18_53542896_53543047 0.13 ENSG00000201816
 .
 203854
 0.03
chr9_34253878_34254029 0.13 ENSG00000222426
 .
 28715
 0.11
chr1_156087932_156088663 0.13 LMNA
 lamin A/C
 3784
 0.13
chr16_9192642_9192817 0.13 RP11-473I1.9
5976
 0.16
chr17_64297613_64298278 0.13 PRKCA
 protein kinase C, alpha
 999
 0.57
chr10_134754880_134755031 0.13 TTC40
 tetratricopeptide repeat domain 40
 1134
 0.61
chr7_116140807_116141026 0.13 CAV2
 caveolin 2
 1082
 0.38
chr5_45163064_45163215 0.13 MRPS30
 mitochondrial ribosomal protein S30
 354112
 0.01
chr19_5293472_5293908 0.13 PTPRS
 protein tyrosine phosphatase, receptor type, S
 427
 0.88
chr12_88966591_88966742 0.13 KITLG
 KIT ligand
 7572
 0.25
chr11_102702875_102703026 0.13 MMP3
 matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 6491
 0.19
chr1_111212990_111213454 0.13 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 4433
 0.21
chr12_39821314_39821465 0.13 KIF21A
 kinesin family member 21A
 15383
 0.23
chr1_156676036_156676613 0.13 CRABP2
 cellular retinoic acid binding protein 2
 716
 0.47
chr2_175496712_175497047 0.13 WIPF1
 WAS/WASL interacting protein family, member 1
 2428
 0.33
chr19_1512246_1512438 0.13 ADAMTSL5
 ADAMTS-like 5
 663
 0.43
chr15_73925957_73926274 0.13 NPTN
 neuroplastin
 360
 0.91
chr18_71409183_71409334 0.13 ENSG00000241866
 .
 2912
 0.42
chr11_108541562_108541713 0.13 DDX10
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
 5788
 0.3
chrX_101410162_101410938 0.13 BEX5
 brain expressed, X-linked 5
 212
 0.92
chr11_128382129_128382364 0.13 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 6957
 0.25
chr16_18033135_18033286 0.13 NPIPA8
 nuclear pore complex interacting protein family, member A8
 384882
 0.01
chr6_158406704_158406855 0.13 SYNJ2
 synaptojanin 2
 3709
 0.23
chr6_130070208_130070770 0.13 ENSG00000211996
 .
 1607
 0.48
chr10_82214562_82215407 0.12 TSPAN14
 tetraspanin 14
 873
 0.63
chr7_104660604_104660779 0.12 KMT2E
 lysine (K)-specific methyltransferase 2E
 5783
 0.17
chr12_13056708_13056859 0.12 GPRC5A
 G protein-coupled receptor, family C, group 5, member A
 5220
 0.15
chr16_80308693_80308866 0.12 DYNLRB2
 dynein, light chain, roadblock-type 2
 265852
 0.02
chr3_9691165_9692185 0.12 MTMR14
 myotubularin related protein 14
 479
 0.8
chr20_61064540_61064691 0.12 GATA5
 GATA binding protein 5
 13589
 0.16
chr5_101952794_101952945 0.12 RP11-58B2.1
111896
 0.07
chr6_149805475_149805626 0.12 ZC3H12D
 zinc finger CCCH-type containing 12D
 576
 0.72
chr8_144815037_144815188 0.12 ENSG00000265660
 .
 211
 0.79
chr4_39355902_39356119 0.12 RFC1
 replication factor C (activator 1) 1, 145kDa
 11959
 0.16
chr1_205473812_205474567 0.12 CDK18
 cyclin-dependent kinase 18
 259
 0.91
chr10_30003940_30004091 0.12 ENSG00000222092
 .
 3171
 0.3
chr17_75663137_75663644 0.12 SEPT9
 septin 9
 185395
 0.03
chr1_208418253_208418520 0.12 PLXNA2
 plexin A2
 721
 0.82

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of NR2F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 0.1 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.1 0.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.2 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.1 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 0.1 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.1 GO:0031579 membrane raft organization(GO:0031579)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.1 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.1 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.0 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.0 GO:0033622 integrin activation(GO:0033622)
0.0 0.0 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.0 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.0 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 0.0 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.0 0.0 GO:0097205 regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0060065 uterus development(GO:0060065)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.0 GO:0090026 regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.0 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.0 GO:0008218 bioluminescence(GO:0008218)
0.0 0.0 GO:0060068 vagina development(GO:0060068)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0035089 establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.0 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.0 GO:0006925 inflammatory cell apoptotic process(GO:0006925)
0.0 0.0 GO:0002507 tolerance induction(GO:0002507)
0.0 0.0 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664)
0.0 0.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.0 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.0 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.0 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.1 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.0 GO:0016939 kinesin II complex(GO:0016939)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.0 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.1 GO:0000977 transcription regulatory region sequence-specific DNA binding(GO:0000976) RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.2 GO:0052866 phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.0 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0043236 laminin binding(GO:0043236)
0.0 0.1 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.0 0.1 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.0 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.0 GO:1990939 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.0 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.0 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.0 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants