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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NR4A1

Z-value: 0.99

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Transcription factors associated with NR4A1

Gene Symbol	Gene ID	Gene Info
NR4A1 Ensembl NCBI GeneCards UniProt	ENSG00000123358.15	NR4A1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NR4A1	chr12_52418688_52418839	2147	0.213783	-0.79	1.1e-02	Click!
NR4A1	chr12_52419741_52419907	3208	0.165001	0.67	4.9e-02	Click!
NR4A1	chr12_52438503_52438654	2989	0.163142	0.62	7.5e-02	Click!
NR4A1	chr12_52431070_52431659	135	0.937063	0.62	7.8e-02	Click!
NR4A1	chr12_52418124_52418275	1583	0.277251	-0.61	7.9e-02	Click!

Activity of the NR4A1 motif across conditions

Conditions sorted by the z-value of the NR4A1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_158252834_158252985	0.45	RP11-52J3.3		1304	0.44
chr4_138531037_138531225	0.42	PCDH18	protocadherin 18	77483	0.13
chr6_81974819_81975050	0.41	RP1-300G12.2		269696	0.02
chr15_60688043_60688242	0.40	ANXA2	annexin A2	1395	0.54
chr12_124872214_124872365	0.40	NCOR2	nuclear receptor corepressor 2	1081	0.65
chr14_55117584_55117850	0.39	SAMD4A	sterile alpha motif domain containing 4A	83080	0.09
chr15_62798764_62798915	0.39	TLN2	talin 2	54725	0.15
chr1_46603624_46603795	0.39	RP4-533D7.5		3506	0.18
chr22_46471692_46472277	0.38	FLJ27365	hsa-mir-4763	4208	0.11
chr22_26852060_26852211	0.34	HPS4	Hermansky-Pudlak syndrome 4	23212	0.12
chr3_16939119_16939271	0.34	PLCL2	phospholipase C-like 2	12743	0.25
chr12_16759185_16759513	0.33	LMO3	LIM domain only 3 (rhombotin-like 2)	116	0.98
chr7_66532196_66532424	0.32	ENSG00000266525	.	47074	0.12
chr3_159745160_159745451	0.32	LINC01100	long intergenic non-protein coding RNA 1100	11494	0.19
chr15_56199751_56199985	0.32	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	7984	0.25
chr3_125321989_125322196	0.32	OSBPL11	oxysterol binding protein-like 11	8158	0.22
chr16_72885110_72885261	0.32	ENSG00000251868	.	29294	0.16
chr6_19838575_19839711	0.31	RP1-167F1.2		168	0.95
chr17_72868164_72868332	0.31	FDXR	ferredoxin reductase	838	0.46
chr1_240760678_240760859	0.30	RP11-467I20.6		6720	0.21
chr18_32995509_32995753	0.30	ZNF396	zinc finger protein 396	38330	0.16
chr12_106478299_106478450	0.30	NUAK1	NUAK family, SNF1-like kinase, 1	558	0.81
chr7_72209303_72209642	0.30	TYW1B	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)	253	0.92
chr3_129322348_129322499	0.29	PLXND1	plexin D1	3238	0.22
chr2_175863049_175863322	0.29	CHN1	chimerin 1	6769	0.16
chr14_51897014_51897206	0.28	FRMD6	FERM domain containing 6	58745	0.13
chr9_130328652_130328977	0.27	FAM129B	family with sequence similarity 129, member B	2553	0.26
chr8_99956690_99957063	0.27	OSR2	odd-skipped related transciption factor 2	11	0.97
chr10_33624842_33625153	0.27	NRP1	neuropilin 1	193	0.96
chr6_84139999_84140706	0.26	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	412	0.89
chr1_157980874_157981318	0.26	KIRREL-IT1	KIRREL intronic transcript 1 (non-protein coding)	14244	0.2
chr1_161992740_161992891	0.26	OLFML2B	olfactomedin-like 2B	615	0.79
chr15_96883153_96883304	0.26	ENSG00000222651	.	6738	0.16
chr4_180106134_180106285	0.25	ENSG00000212191	.	499099	0.0
chr12_58819523_58819907	0.25	RP11-362K2.2	Protein LOC100506869	118192	0.06
chr7_90033445_90033883	0.25	CLDN12	claudin 12	783	0.69
chr17_17804572_17804723	0.25	TOM1L2	target of myb1-like 2 (chicken)	29269	0.14
chr15_48010788_48011252	0.25	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	334	0.93
chr17_79315981_79316442	0.24	TMEM105	transmembrane protein 105	11737	0.13
chr5_108790950_108791101	0.24	PJA2	praja ring finger 2, E3 ubiquitin protein ligase	45330	0.2
chr2_189842191_189842342	0.23	ENSG00000221502	.	552	0.78
chr8_119115834_119115985	0.23	EXT1	exostosin glycosyltransferase 1	6744	0.34
chr1_47489778_47489953	0.23	CYP4X1	cytochrome P450, family 4, subfamily X, polypeptide 1	625	0.75
chr6_17417832_17418048	0.23	CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	23997	0.25
chr7_83819706_83819857	0.23	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	4436	0.37
chrX_39759988_39760170	0.23	ENSG00000263972	.	63264	0.14
chr17_38439762_38439991	0.23	CDC6	cell division cycle 6	4009	0.16
chr8_61626221_61626372	0.22	CHD7	chromodomain helicase DNA binding protein 7	27628	0.23
chr3_11633135_11633286	0.22	VGLL4	vestigial like 4 (Drosophila)	9345	0.2
chr2_238316542_238316753	0.22	COL6A3	collagen, type VI, alpha 3	6144	0.22
chr14_20903201_20903901	0.22	KLHL33	kelch-like family member 33	250	0.81
chr1_172105427_172105578	0.22	ENSG00000207949	.	2545	0.27
chr17_13503336_13503489	0.22	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	1832	0.45
chr22_24109124_24109275	0.22	CHCHD10	coiled-coil-helix-coiled-coil-helix domain containing 10	864	0.37
chr6_149068477_149068835	0.22	UST	uronyl-2-sulfotransferase	192	0.97
chr4_177714164_177714554	0.22	VEGFC	vascular endothelial growth factor C	478	0.89
chr12_54417118_54417269	0.21	HOXC6	homeobox C6	4949	0.07
chr18_11096558_11096709	0.21	PIEZO2	piezo-type mechanosensitive ion channel component 2	51954	0.18
chr12_16758688_16759086	0.21	LMO3	LIM domain only 3 (rhombotin-like 2)	17	0.99
chr7_2842191_2842738	0.21	GNA12	guanine nucleotide binding protein (G protein) alpha 12	12428	0.25
chr17_5326109_5326345	0.21	RPAIN	RPA interacting protein	2705	0.15
chr6_150176715_150177267	0.21	RP11-350J20.12		3393	0.15
chr4_177707466_177707742	0.21	VEGFC	vascular endothelial growth factor C	6277	0.32
chr10_4283577_4283877	0.21	ENSG00000207124	.	273417	0.02
chr19_17797231_17797557	0.21	UNC13A	unc-13 homolog A (C. elegans)	1614	0.31
chr8_74333530_74333818	0.21	RP11-434I12.2		64978	0.13
chrX_31284306_31284787	0.21	DMD	dystrophin	428	0.9
chr8_22025466_22025617	0.21	BMP1	bone morphogenetic protein 1	2741	0.16
chr9_133590287_133590909	0.21	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	1231	0.49
chr10_93373658_93374073	0.20	PPP1R3C	protein phosphatase 1, regulatory subunit 3C	18946	0.27
chr21_17652021_17652264	0.20	ENSG00000201025	.	4947	0.35
chr7_25469565_25469726	0.20	ENSG00000222101	.	140643	0.05
chr9_18476160_18476529	0.20	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr8_135212673_135212824	0.20	ZFAT	zinc finger and AT hook domain containing	309677	0.01
chrX_135230667_135231011	0.20	FHL1	four and a half LIM domains 1	102	0.97
chr5_135389675_135389826	0.20	TGFBI	transforming growth factor, beta-induced, 68kDa	4545	0.23
chr20_60931125_60931499	0.20	RP11-157P1.5		3243	0.15
chr13_52164714_52165080	0.20	ENSG00000242893	.	3454	0.16
chr6_43485479_43485674	0.20	POLR1C	polymerase (RNA) I polypeptide C, 30kDa	726	0.33
chr5_58187479_58187710	0.19	CTD-2176I21.2		28353	0.22
chr6_58148368_58148782	0.19	ENSG00000212017	.	893645	0.0
chr2_227657217_227657687	0.19	IRS1	insulin receptor substrate 1	7023	0.22
chr6_116571521_116571672	0.19	TSPYL4	TSPY-like 4	3665	0.18
chr3_143568633_143568784	0.19	SLC9A9	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	1335	0.61
chr7_84119974_84120125	0.19	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	1816	0.53
chr12_26110310_26110527	0.19	RASSF8-AS1	RASSF8 atnisense RNA 1	100	0.96
chr2_219149046_219149220	0.19	TMBIM1	transmembrane BAX inhibitor motif containing 1	1524	0.24
chr12_115889903_115890336	0.19	RP11-116D17.1	HCG2038717; Uncharacterized protein	89302	0.1
chr4_7136849_7137000	0.19	ENSG00000200867	.	22798	0.16
chr7_43651852_43652098	0.18	STK17A	serine/threonine kinase 17a	29311	0.15
chr6_26721817_26722019	0.18	ZNF322	zinc finger protein 322	61938	0.11
chr12_96590087_96590334	0.18	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	1818	0.37
chr1_228272671_228272822	0.18	ARF1	ADP-ribosylation factor 1	1895	0.23
chr3_59110595_59110926	0.18	C3orf67	chromosome 3 open reading frame 67	74950	0.13
chr5_169369055_169369206	0.17	FAM196B	family with sequence similarity 196, member B	38614	0.19
chr9_116569857_116570008	0.17	ENSG00000211556	.	15213	0.25
chr12_45628611_45628785	0.17	ANO6	anoctamin 6	18795	0.27
chr7_90711533_90711739	0.17	FZD1	frizzled family receptor 1	182147	0.03
chr5_98397075_98397538	0.17	ENSG00000200351	.	124855	0.06
chr22_30022409_30022560	0.17	NF2	neurofibromin 2 (merlin)	22496	0.14
chr15_96879714_96879865	0.17	ENSG00000222651	.	3299	0.19
chr1_43218988_43219139	0.17	LEPRE1	leucine proline-enriched proteoglycan (leprecan) 1	1595	0.28
chr8_25868117_25868310	0.17	EBF2	early B-cell factor 2	30791	0.24
chr7_73130944_73131128	0.17	STX1A	syntaxin 1A (brain)	2925	0.14
chr16_10678659_10678810	0.17	EMP2	epithelial membrane protein 2	4179	0.21
chr20_61863942_61864093	0.17	BIRC7	baculoviral IAP repeat containing 7	3218	0.15
chr6_3749707_3750198	0.17	RP11-420L9.5		1393	0.41
chr6_26745930_26746188	0.17	ZNF322	zinc finger protein 322	86079	0.08
chr8_97536368_97536646	0.17	SDC2	syndecan 2	30271	0.22
chr7_32627060_32627248	0.17	AVL9	AVL9 homolog (S. cerevisiase)	44287	0.18
chr3_197099341_197099661	0.17	ENSG00000238491	.	33079	0.17
chr10_93170267_93170919	0.17	HECTD2	HECT domain containing E3 ubiquitin protein ligase 2	491	0.89
chr4_157695428_157695747	0.17	RP11-154F14.2		66924	0.12
chrX_22670943_22671094	0.17	ENSG00000265819	.	15909	0.29
chr10_15390844_15391029	0.16	FAM171A1	family with sequence similarity 171, member A1	22122	0.25
chr22_44756680_44757093	0.16	RP1-32I10.10	Uncharacterized protein	4545	0.29
chr17_41476988_41477313	0.16	ARL4D	ADP-ribosylation factor-like 4D	823	0.46
chr4_105416319_105416884	0.16	CXXC4	CXXC finger protein 4	550	0.77
chr8_99438878_99439083	0.16	KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	270	0.92
chr6_28641788_28642196	0.16	ENSG00000272278	.	25950	0.18
chr2_150187104_150187520	0.16	LYPD6	LY6/PLAUR domain containing 6	261	0.96
chr6_155654647_155654798	0.16	TFB1M	transcription factor B1, mitochondrial	19104	0.23
chr8_495040_495212	0.16	TDRP	testis development related protein	128	0.98
chr15_95847267_95847418	0.16	ENSG00000222076	.	441691	0.01
chr22_31479185_31479426	0.16	RP3-412A9.16		246	0.8
chr2_3699150_3699650	0.16	ALLC	allantoicase	6385	0.16
chr2_192111446_192111930	0.16	MYO1B	myosin IB	679	0.79
chr15_57669149_57669410	0.16	CGNL1	cingulin-like 1	576	0.8
chr16_88922465_88922880	0.15	TRAPPC2L	trafficking protein particle complex 2-like	44	0.8
chr6_5499328_5499479	0.15	RP1-232P20.1		41095	0.2
chr8_32406806_32407051	0.15	NRG1	neuregulin 1	683	0.82
chr7_95401616_95402462	0.15	DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1	123	0.98
chr12_12658847_12659363	0.15	DUSP16	dual specificity phosphatase 16	14954	0.24
chr9_73216401_73216607	0.15	ENSG00000272232	.	22127	0.25
chr10_62587657_62587808	0.15	CDK1	cyclin-dependent kinase 1	47821	0.16
chr5_58484501_58484817	0.15	PDE4D	phosphodiesterase 4D, cAMP-specific	87286	0.1
chr2_207905869_207906341	0.15	ENSG00000253008	.	68692	0.1
chr18_52625984_52626182	0.15	CCDC68	coiled-coil domain containing 68	656	0.76
chr2_208199752_208200019	0.15	ENSG00000221628	.	65737	0.12
chr2_42599068_42599219	0.15	COX7A2L	cytochrome c oxidase subunit VIIa polypeptide 2 like	2993	0.32
chr1_144928639_144928790	0.15	PDE4DIP	phosphodiesterase 4D interacting protein	3434	0.19
chr5_154229931_154230213	0.15	FAXDC2	fatty acid hydroxylase domain containing 2	91	0.96
chr7_13056983_13057208	0.15	ENSG00000222974	.	140786	0.05
chr6_99962436_99962683	0.15	USP45	ubiquitin specific peptidase 45	693	0.65
chr18_32173182_32173613	0.15	DTNA	dystrobrevin, alpha	68	0.99
chr4_129439243_129439469	0.15	PGRMC2	progesterone receptor membrane component 2	229372	0.02
chr22_36138598_36138911	0.15	APOL5	apolipoprotein L, 5	24835	0.19
chr3_149371875_149372212	0.15	WWTR1-AS1	WWTR1 antisense RNA 1	2764	0.22
chrX_100334578_100334939	0.15	TMEM35	transmembrane protein 35	1049	0.47
chr4_108314088_108314239	0.15	ENSG00000252470	.	42112	0.2
chr2_135130087_135130255	0.14	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	118341	0.06
chr2_234390115_234390266	0.14	USP40	ubiquitin specific peptidase 40	7917	0.22
chr4_181748441_181748629	0.14	NA	NA	> 10⁶	NA
chr1_12609904_12610111	0.14	ENSG00000221340	.	20093	0.16
chr5_52333250_52333558	0.14	CTD-2175A23.1		47296	0.12
chr16_25022284_25022579	0.14	ARHGAP17	Rho GTPase activating protein 17	4221	0.31
chr14_52584008_52584159	0.14	NID2	nidogen 2 (osteonidogen)	48371	0.15
chr4_170086286_170086437	0.14	RP11-327O17.2		36584	0.2
chr11_133917712_133918072	0.14	JAM3	junctional adhesion molecule 3	20928	0.21
chr21_30464791_30465071	0.14	MAP3K7CL	MAP3K7 C-terminal like	356	0.83
chr10_128076215_128076453	0.14	ADAM12	ADAM metallopeptidase domain 12	690	0.79
chr13_110780795_110780946	0.14	ENSG00000265885	.	30372	0.24
chr8_16815000_16815151	0.14	FGF20	fibroblast growth factor 20	44274	0.17
chr17_6451663_6451961	0.14	PITPNM3	PITPNM family member 3	7968	0.17
chr15_51039395_51039546	0.14	SPPL2A	signal peptide peptidase like 2A	258	0.75
chr5_141703297_141704624	0.14	SPRY4	sprouty homolog 4 (Drosophila)	213	0.88
chr10_36184487_36184638	0.14	FZD8	frizzled family receptor 8	254200	0.02
chr3_185651354_185651505	0.14	TRA2B	transformer 2 beta homolog (Drosophila)	4372	0.23
chr19_18761571_18761809	0.14	KLHL26	kelch-like family member 26	13823	0.1
chr16_85202371_85202571	0.14	CTC-786C10.1		2411	0.35
chr11_101278345_101278496	0.14	ENSG00000263885	.	112216	0.07
chr4_81198150_81198317	0.14	FGF5	fibroblast growth factor 5	10440	0.25
chr2_145417620_145417771	0.14	ZEB2	zinc finger E-box binding homeobox 2	139074	0.05
chr9_40631681_40631832	0.14	SPATA31A3	SPATA31 subfamily A, member 3	68535	0.13
chr19_8426733_8426884	0.14	ANGPTL4	angiopoietin-like 4	1365	0.25
chr9_89996647_89996873	0.14	DAPK1	death-associated protein kinase 1	115383	0.06
chr2_138721657_138722065	0.14	HNMT	histamine N-methyltransferase	19	0.99
chr1_9473851_9474134	0.14	ENSG00000252956	.	23845	0.2
chr19_2639313_2639495	0.13	CTC-265F19.1		4447	0.15
chr13_42616117_42616369	0.13	DGKH	diacylglycerol kinase, eta	2067	0.3
chr18_32290285_32290488	0.13	DTNA	dystrobrevin, alpha	125	0.98
chr3_58258156_58258366	0.13	RPP14	ribonuclease P/MRP 14kDa subunit	33728	0.14
chr1_16702300_16702515	0.13	SZRD1	SUZ RNA binding domain containing 1	8647	0.15
chr2_47260836_47261197	0.13	AC093732.1		6647	0.2
chr2_44625453_44625606	0.13	CAMKMT	calmodulin-lysine N-methyltransferase	25648	0.2
chr17_46561109_46561276	0.13	ENSG00000206805	.	4733	0.14
chr2_24398914_24399065	0.13	FAM228A	family with sequence similarity 228, member A	635	0.51
chr2_166430745_166430996	0.13	CSRNP3	cysteine-serine-rich nuclear protein 3	251	0.96
chr18_60904701_60905063	0.13	ENSG00000238988	.	42984	0.14
chr14_94426547_94426698	0.13	ASB2	ankyrin repeat and SOCS box containing 2	2855	0.21
chr6_1311351_1312220	0.13	FOXQ1	forkhead box Q1	890	0.69
chr8_77596836_77596987	0.13	ZFHX4	zinc finger homeobox 4	895	0.54
chr14_62033353_62033504	0.13	RP11-47I22.3	Uncharacterized protein	3886	0.24
chr18_25754335_25754486	0.13	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	3000	0.42
chr17_42624321_42624535	0.13	FZD2	frizzled family receptor 2	10497	0.18
chr11_131758303_131758454	0.13	AP004372.1		8624	0.25
chr12_66093282_66093481	0.13	HMGA2	high mobility group AT-hook 2	124530	0.05
chr2_101437362_101437649	0.13	NPAS2	neuronal PAS domain protein 2	18	0.97
chr10_29824642_29824876	0.13	ENSG00000207612	.	9267	0.19
chr3_75690482_75691208	0.13	ENSG00000221795	.	10931	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1	0.3	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.1	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.2	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.3	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.1	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.1	GO:0031223	auditory behavior(GO:0031223)
0.0	0.2	GO:0099518	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.2	GO:0002347	response to tumor cell(GO:0002347)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.2	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.0	GO:0061042	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.3	GO:0043034	costamere(GO:0043034)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.2	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.1	GO:0042587	glycogen granule(GO:0042587)
0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	GO:0033270	paranode region of axon(GO:0033270)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.2	GO:0004470	malic enzyme activity(GO:0004470)
0.1	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.3	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.3	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.3	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.0	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII