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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for NR4A1

Z-value: 0.99

Motif logo

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Transcription factors associated with NR4A1

Gene Symbol Gene ID Gene Info
NR4A1
ENSG00000123358.15 nuclear receptor subfamily 4 group A member 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_52418688_52418839NR4A121470.213783-0.791.1e-02Click!
chr12_52419741_52419907NR4A132080.1650010.674.9e-02Click!
chr12_52438503_52438654NR4A129890.1631420.627.5e-02Click!
chr12_52431070_52431659NR4A11350.9370630.627.8e-02Click!
chr12_52418124_52418275NR4A115830.277251-0.617.9e-02Click!

Activity of the NR4A1 motif across conditions

Conditions sorted by the z-value of the NR4A1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_158252834_158252985 0.45 RP11-52J3.3
1304
 0.44
chr4_138531037_138531225 0.42 PCDH18
 protocadherin 18
 77483
 0.13
chr6_81974819_81975050 0.41 RP1-300G12.2
269696
 0.02
chr15_60688043_60688242 0.40 ANXA2
 annexin A2
 1395
 0.54
chr12_124872214_124872365 0.40 NCOR2
 nuclear receptor corepressor 2
 1081
 0.65
chr14_55117584_55117850 0.39 SAMD4A
 sterile alpha motif domain containing 4A
 83080
 0.09
chr15_62798764_62798915 0.39 TLN2
 talin 2
 54725
 0.15
chr1_46603624_46603795 0.39 RP4-533D7.5
3506
 0.18
chr22_46471692_46472277 0.38 FLJ27365
 hsa-mir-4763
 4208
 0.11
chr22_26852060_26852211 0.34 HPS4
 Hermansky-Pudlak syndrome 4
 23212
 0.12
chr3_16939119_16939271 0.34 PLCL2
 phospholipase C-like 2
 12743
 0.25
chr12_16759185_16759513 0.33 LMO3
 LIM domain only 3 (rhombotin-like 2)
 116
 0.98
chr7_66532196_66532424 0.32 ENSG00000266525
 .
 47074
 0.12
chr3_159745160_159745451 0.32 LINC01100
 long intergenic non-protein coding RNA 1100
 11494
 0.19
chr15_56199751_56199985 0.32 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
 7984
 0.25
chr3_125321989_125322196 0.32 OSBPL11
 oxysterol binding protein-like 11
 8158
 0.22
chr16_72885110_72885261 0.32 ENSG00000251868
 .
 29294
 0.16
chr6_19838575_19839711 0.31 RP1-167F1.2
168
 0.95
chr17_72868164_72868332 0.31 FDXR
 ferredoxin reductase
 838
 0.46
chr1_240760678_240760859 0.30 RP11-467I20.6
6720
 0.21
chr18_32995509_32995753 0.30 ZNF396
 zinc finger protein 396
 38330
 0.16
chr12_106478299_106478450 0.30 NUAK1
 NUAK family, SNF1-like kinase, 1
 558
 0.81
chr7_72209303_72209642 0.30 TYW1B
 tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)
 253
 0.92
chr3_129322348_129322499 0.29 PLXND1
 plexin D1
 3238
 0.22
chr2_175863049_175863322 0.29 CHN1
 chimerin 1
 6769
 0.16
chr14_51897014_51897206 0.28 FRMD6
 FERM domain containing 6
 58745
 0.13
chr9_130328652_130328977 0.27 FAM129B
 family with sequence similarity 129, member B
 2553
 0.26
chr8_99956690_99957063 0.27 OSR2
 odd-skipped related transciption factor 2
 11
 0.97
chr10_33624842_33625153 0.27 NRP1
 neuropilin 1
 193
 0.96
chr6_84139999_84140706 0.26 ME1
 malic enzyme 1, NADP(+)-dependent, cytosolic
 412
 0.89
chr1_157980874_157981318 0.26 KIRREL-IT1
 KIRREL intronic transcript 1 (non-protein coding)
 14244
 0.2
chr1_161992740_161992891 0.26 OLFML2B
 olfactomedin-like 2B
 615
 0.79
chr15_96883153_96883304 0.26 ENSG00000222651
 .
 6738
 0.16
chr4_180106134_180106285 0.25 ENSG00000212191
 .
 499099
 0.0
chr12_58819523_58819907 0.25 RP11-362K2.2
 Protein LOC100506869
 118192
 0.06
chr7_90033445_90033883 0.25 CLDN12
 claudin 12
 783
 0.69
chr17_17804572_17804723 0.25 TOM1L2
 target of myb1-like 2 (chicken)
 29269
 0.14
chr15_48010788_48011252 0.25 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 334
 0.93
chr17_79315981_79316442 0.24 TMEM105
 transmembrane protein 105
 11737
 0.13
chr5_108790950_108791101 0.24 PJA2
 praja ring finger 2, E3 ubiquitin protein ligase
 45330
 0.2
chr2_189842191_189842342 0.23 ENSG00000221502
 .
 552
 0.78
chr8_119115834_119115985 0.23 EXT1
 exostosin glycosyltransferase 1
 6744
 0.34
chr1_47489778_47489953 0.23 CYP4X1
 cytochrome P450, family 4, subfamily X, polypeptide 1
 625
 0.75
chr6_17417832_17418048 0.23 CAP2
 CAP, adenylate cyclase-associated protein, 2 (yeast)
 23997
 0.25
chr7_83819706_83819857 0.23 SEMA3A
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 4436
 0.37
chrX_39759988_39760170 0.23 ENSG00000263972
 .
 63264
 0.14
chr17_38439762_38439991 0.23 CDC6
 cell division cycle 6
 4009
 0.16
chr8_61626221_61626372 0.22 CHD7
 chromodomain helicase DNA binding protein 7
 27628
 0.23
chr3_11633135_11633286 0.22 VGLL4
 vestigial like 4 (Drosophila)
 9345
 0.2
chr2_238316542_238316753 0.22 COL6A3
 collagen, type VI, alpha 3
 6144
 0.22
chr14_20903201_20903901 0.22 KLHL33
 kelch-like family member 33
 250
 0.81
chr1_172105427_172105578 0.22 ENSG00000207949
 .
 2545
 0.27
chr17_13503336_13503489 0.22 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 1832
 0.45
chr22_24109124_24109275 0.22 CHCHD10
 coiled-coil-helix-coiled-coil-helix domain containing 10
 864
 0.37
chr6_149068477_149068835 0.22 UST
 uronyl-2-sulfotransferase
 192
 0.97
chr4_177714164_177714554 0.22 VEGFC
 vascular endothelial growth factor C
 478
 0.89
chr12_54417118_54417269 0.21 HOXC6
 homeobox C6
 4949
 0.07
chr18_11096558_11096709 0.21 PIEZO2
 piezo-type mechanosensitive ion channel component 2
 51954
 0.18
chr12_16758688_16759086 0.21 LMO3
 LIM domain only 3 (rhombotin-like 2)
 17
 0.99
chr7_2842191_2842738 0.21 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
 12428
 0.25
chr17_5326109_5326345 0.21 RPAIN
 RPA interacting protein
 2705
 0.15
chr6_150176715_150177267 0.21 RP11-350J20.12
3393
 0.15
chr4_177707466_177707742 0.21 VEGFC
 vascular endothelial growth factor C
 6277
 0.32
chr10_4283577_4283877 0.21 ENSG00000207124
 .
 273417
 0.02
chr19_17797231_17797557 0.21 UNC13A
 unc-13 homolog A (C. elegans)
 1614
 0.31
chr8_74333530_74333818 0.21 RP11-434I12.2
64978
 0.13
chrX_31284306_31284787 0.21 DMD
 dystrophin
 428
 0.9
chr8_22025466_22025617 0.21 BMP1
 bone morphogenetic protein 1
 2741
 0.16
chr9_133590287_133590909 0.21 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 1231
 0.49
chr10_93373658_93374073 0.20 PPP1R3C
 protein phosphatase 1, regulatory subunit 3C
 18946
 0.27
chr21_17652021_17652264 0.20 ENSG00000201025
 .
 4947
 0.35
chr7_25469565_25469726 0.20 ENSG00000222101
 .
 140643
 0.05
chr9_18476160_18476529 0.20 ADAMTSL1
 ADAMTS-like 1
 2113
 0.45
chr8_135212673_135212824 0.20 ZFAT
 zinc finger and AT hook domain containing
 309677
 0.01
chrX_135230667_135231011 0.20 FHL1
 four and a half LIM domains 1
 102
 0.97
chr5_135389675_135389826 0.20 TGFBI
 transforming growth factor, beta-induced, 68kDa
 4545
 0.23
chr20_60931125_60931499 0.20 RP11-157P1.5
3243
 0.15
chr13_52164714_52165080 0.20 ENSG00000242893
 .
 3454
 0.16
chr6_43485479_43485674 0.20 POLR1C
 polymerase (RNA) I polypeptide C, 30kDa
 726
 0.33
chr5_58187479_58187710 0.19 CTD-2176I21.2
28353
 0.22
chr6_58148368_58148782 0.19 ENSG00000212017
 .
 893645
 0.0
chr2_227657217_227657687 0.19 IRS1
 insulin receptor substrate 1
 7023
 0.22
chr6_116571521_116571672 0.19 TSPYL4
 TSPY-like 4
 3665
 0.18
chr3_143568633_143568784 0.19 SLC9A9
 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
 1335
 0.61
chr7_84119974_84120125 0.19 SEMA3A
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 1816
 0.53
chr12_26110310_26110527 0.19 RASSF8-AS1
 RASSF8 atnisense RNA 1
 100
 0.96
chr2_219149046_219149220 0.19 TMBIM1
 transmembrane BAX inhibitor motif containing 1
 1524
 0.24
chr12_115889903_115890336 0.19 RP11-116D17.1
 HCG2038717; Uncharacterized protein
 89302
 0.1
chr4_7136849_7137000 0.19 ENSG00000200867
 .
 22798
 0.16
chr7_43651852_43652098 0.18 STK17A
 serine/threonine kinase 17a
 29311
 0.15
chr6_26721817_26722019 0.18 ZNF322
 zinc finger protein 322
 61938
 0.11
chr12_96590087_96590334 0.18 ELK3
 ELK3, ETS-domain protein (SRF accessory protein 2)
 1818
 0.37
chr1_228272671_228272822 0.18 ARF1
 ADP-ribosylation factor 1
 1895
 0.23
chr3_59110595_59110926 0.18 C3orf67
 chromosome 3 open reading frame 67
 74950
 0.13
chr5_169369055_169369206 0.17 FAM196B
 family with sequence similarity 196, member B
 38614
 0.19
chr9_116569857_116570008 0.17 ENSG00000211556
 .
 15213
 0.25
chr12_45628611_45628785 0.17 ANO6
 anoctamin 6
 18795
 0.27
chr7_90711533_90711739 0.17 FZD1
 frizzled family receptor 1
 182147
 0.03
chr5_98397075_98397538 0.17 ENSG00000200351
 .
 124855
 0.06
chr22_30022409_30022560 0.17 NF2
 neurofibromin 2 (merlin)
 22496
 0.14
chr15_96879714_96879865 0.17 ENSG00000222651
 .
 3299
 0.19
chr1_43218988_43219139 0.17 LEPRE1
 leucine proline-enriched proteoglycan (leprecan) 1
 1595
 0.28
chr8_25868117_25868310 0.17 EBF2
 early B-cell factor 2
 30791
 0.24
chr7_73130944_73131128 0.17 STX1A
 syntaxin 1A (brain)
 2925
 0.14
chr16_10678659_10678810 0.17 EMP2
 epithelial membrane protein 2
 4179
 0.21
chr20_61863942_61864093 0.17 BIRC7
 baculoviral IAP repeat containing 7
 3218
 0.15
chr6_3749707_3750198 0.17 RP11-420L9.5
1393
 0.41
chr6_26745930_26746188 0.17 ZNF322
 zinc finger protein 322
 86079
 0.08
chr8_97536368_97536646 0.17 SDC2
 syndecan 2
 30271
 0.22
chr7_32627060_32627248 0.17 AVL9
 AVL9 homolog (S. cerevisiase)
 44287
 0.18
chr3_197099341_197099661 0.17 ENSG00000238491
 .
 33079
 0.17
chr10_93170267_93170919 0.17 HECTD2
 HECT domain containing E3 ubiquitin protein ligase 2
 491
 0.89
chr4_157695428_157695747 0.17 RP11-154F14.2
66924
 0.12
chrX_22670943_22671094 0.17 ENSG00000265819
 .
 15909
 0.29
chr10_15390844_15391029 0.16 FAM171A1
 family with sequence similarity 171, member A1
 22122
 0.25
chr22_44756680_44757093 0.16 RP1-32I10.10
 Uncharacterized protein
 4545
 0.29
chr17_41476988_41477313 0.16 ARL4D
 ADP-ribosylation factor-like 4D
 823
 0.46
chr4_105416319_105416884 0.16 CXXC4
 CXXC finger protein 4
 550
 0.77
chr8_99438878_99439083 0.16 KCNS2
 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
 270
 0.92
chr6_28641788_28642196 0.16 ENSG00000272278
 .
 25950
 0.18
chr2_150187104_150187520 0.16 LYPD6
 LY6/PLAUR domain containing 6
 261
 0.96
chr6_155654647_155654798 0.16 TFB1M
 transcription factor B1, mitochondrial
 19104
 0.23
chr8_495040_495212 0.16 TDRP
 testis development related protein
 128
 0.98
chr15_95847267_95847418 0.16 ENSG00000222076
 .
 441691
 0.01
chr22_31479185_31479426 0.16 RP3-412A9.16
246
 0.8
chr2_3699150_3699650 0.16 ALLC
 allantoicase
 6385
 0.16
chr2_192111446_192111930 0.16 MYO1B
 myosin IB
 679
 0.79
chr15_57669149_57669410 0.16 CGNL1
 cingulin-like 1
 576
 0.8
chr16_88922465_88922880 0.15 TRAPPC2L
 trafficking protein particle complex 2-like
 44
 0.8
chr6_5499328_5499479 0.15 RP1-232P20.1
41095
 0.2
chr8_32406806_32407051 0.15 NRG1
 neuregulin 1
 683
 0.82
chr7_95401616_95402462 0.15 DYNC1I1
 dynein, cytoplasmic 1, intermediate chain 1
 123
 0.98
chr12_12658847_12659363 0.15 DUSP16
 dual specificity phosphatase 16
 14954
 0.24
chr9_73216401_73216607 0.15 ENSG00000272232
 .
 22127
 0.25
chr10_62587657_62587808 0.15 CDK1
 cyclin-dependent kinase 1
 47821
 0.16
chr5_58484501_58484817 0.15 PDE4D
 phosphodiesterase 4D, cAMP-specific
 87286
 0.1
chr2_207905869_207906341 0.15 ENSG00000253008
 .
 68692
 0.1
chr18_52625984_52626182 0.15 CCDC68
 coiled-coil domain containing 68
 656
 0.76
chr2_208199752_208200019 0.15 ENSG00000221628
 .
 65737
 0.12
chr2_42599068_42599219 0.15 COX7A2L
 cytochrome c oxidase subunit VIIa polypeptide 2 like
 2993
 0.32
chr1_144928639_144928790 0.15 PDE4DIP
 phosphodiesterase 4D interacting protein
 3434
 0.19
chr5_154229931_154230213 0.15 FAXDC2
 fatty acid hydroxylase domain containing 2
 91
 0.96
chr7_13056983_13057208 0.15 ENSG00000222974
 .
 140786
 0.05
chr6_99962436_99962683 0.15 USP45
 ubiquitin specific peptidase 45
 693
 0.65
chr18_32173182_32173613 0.15 DTNA
 dystrobrevin, alpha
 68
 0.99
chr4_129439243_129439469 0.15 PGRMC2
 progesterone receptor membrane component 2
 229372
 0.02
chr22_36138598_36138911 0.15 APOL5
 apolipoprotein L, 5
 24835
 0.19
chr3_149371875_149372212 0.15 WWTR1-AS1
 WWTR1 antisense RNA 1
 2764
 0.22
chrX_100334578_100334939 0.15 TMEM35
 transmembrane protein 35
 1049
 0.47
chr4_108314088_108314239 0.15 ENSG00000252470
 .
 42112
 0.2
chr2_135130087_135130255 0.14 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 118341
 0.06
chr2_234390115_234390266 0.14 USP40
 ubiquitin specific peptidase 40
 7917
 0.22
chr4_181748441_181748629 0.14 NA
 NA
 > 106
 NA
chr1_12609904_12610111 0.14 ENSG00000221340
 .
 20093
 0.16
chr5_52333250_52333558 0.14 CTD-2175A23.1
47296
 0.12
chr16_25022284_25022579 0.14 ARHGAP17
 Rho GTPase activating protein 17
 4221
 0.31
chr14_52584008_52584159 0.14 NID2
 nidogen 2 (osteonidogen)
 48371
 0.15
chr4_170086286_170086437 0.14 RP11-327O17.2
36584
 0.2
chr11_133917712_133918072 0.14 JAM3
 junctional adhesion molecule 3
 20928
 0.21
chr21_30464791_30465071 0.14 MAP3K7CL
 MAP3K7 C-terminal like
 356
 0.83
chr10_128076215_128076453 0.14 ADAM12
 ADAM metallopeptidase domain 12
 690
 0.79
chr13_110780795_110780946 0.14 ENSG00000265885
 .
 30372
 0.24
chr8_16815000_16815151 0.14 FGF20
 fibroblast growth factor 20
 44274
 0.17
chr17_6451663_6451961 0.14 PITPNM3
 PITPNM family member 3
 7968
 0.17
chr15_51039395_51039546 0.14 SPPL2A
 signal peptide peptidase like 2A
 258
 0.75
chr5_141703297_141704624 0.14 SPRY4
 sprouty homolog 4 (Drosophila)
 213
 0.88
chr10_36184487_36184638 0.14 FZD8
 frizzled family receptor 8
 254200
 0.02
chr3_185651354_185651505 0.14 TRA2B
 transformer 2 beta homolog (Drosophila)
 4372
 0.23
chr19_18761571_18761809 0.14 KLHL26
 kelch-like family member 26
 13823
 0.1
chr16_85202371_85202571 0.14 CTC-786C10.1
2411
 0.35
chr11_101278345_101278496 0.14 ENSG00000263885
 .
 112216
 0.07
chr4_81198150_81198317 0.14 FGF5
 fibroblast growth factor 5
 10440
 0.25
chr2_145417620_145417771 0.14 ZEB2
 zinc finger E-box binding homeobox 2
 139074
 0.05
chr9_40631681_40631832 0.14 SPATA31A3
 SPATA31 subfamily A, member 3
 68535
 0.13
chr19_8426733_8426884 0.14 ANGPTL4
 angiopoietin-like 4
 1365
 0.25
chr9_89996647_89996873 0.14 DAPK1
 death-associated protein kinase 1
 115383
 0.06
chr2_138721657_138722065 0.14 HNMT
 histamine N-methyltransferase
 19
 0.99
chr1_9473851_9474134 0.14 ENSG00000252956
 .
 23845
 0.2
chr19_2639313_2639495 0.13 CTC-265F19.1
4447
 0.15
chr13_42616117_42616369 0.13 DGKH
 diacylglycerol kinase, eta
 2067
 0.3
chr18_32290285_32290488 0.13 DTNA
 dystrobrevin, alpha
 125
 0.98
chr3_58258156_58258366 0.13 RPP14
 ribonuclease P/MRP 14kDa subunit
 33728
 0.14
chr1_16702300_16702515 0.13 SZRD1
 SUZ RNA binding domain containing 1
 8647
 0.15
chr2_47260836_47261197 0.13 AC093732.1
6647
 0.2
chr2_44625453_44625606 0.13 CAMKMT
 calmodulin-lysine N-methyltransferase
 25648
 0.2
chr17_46561109_46561276 0.13 ENSG00000206805
 .
 4733
 0.14
chr2_24398914_24399065 0.13 FAM228A
 family with sequence similarity 228, member A
 635
 0.51
chr2_166430745_166430996 0.13 CSRNP3
 cysteine-serine-rich nuclear protein 3
 251
 0.96
chr18_60904701_60905063 0.13 ENSG00000238988
 .
 42984
 0.14
chr14_94426547_94426698 0.13 ASB2
 ankyrin repeat and SOCS box containing 2
 2855
 0.21
chr6_1311351_1312220 0.13 FOXQ1
 forkhead box Q1
 890
 0.69
chr8_77596836_77596987 0.13 ZFHX4
 zinc finger homeobox 4
 895
 0.54
chr14_62033353_62033504 0.13 RP11-47I22.3
 Uncharacterized protein
 3886
 0.24
chr18_25754335_25754486 0.13 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 3000
 0.42
chr17_42624321_42624535 0.13 FZD2
 frizzled family receptor 2
 10497
 0.18
chr11_131758303_131758454 0.13 AP004372.1
8624
 0.25
chr12_66093282_66093481 0.13 HMGA2
 high mobility group AT-hook 2
 124530
 0.05
chr2_101437362_101437649 0.13 NPAS2
 neuronal PAS domain protein 2
 18
 0.97
chr10_29824642_29824876 0.13 ENSG00000207612
 .
 9267
 0.19
chr3_75690482_75691208 0.13 ENSG00000221795
 .
 10931
 0.2

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.3 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.3 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0018119 protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.2 GO:0099518 vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.2 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.0 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.0 GO:0045634 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.0 GO:0032413 negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.0 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.0 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.0 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.2 GO:0042745 circadian sleep/wake cycle(GO:0042745)
0.0 0.0 GO:0061042 vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.0 GO:0051590 positive regulation of neurotransmitter transport(GO:0051590)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.0 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.2 GO:0004470 malic enzyme activity(GO:0004470)
0.1 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.0 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.0 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.0 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII