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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NR4A2

Z-value: 0.40

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Transcription factors associated with NR4A2

Gene Symbol	Gene ID	Gene Info
NR4A2 Ensembl NCBI GeneCards UniProt	ENSG00000153234.9	NR4A2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NR4A2	chr2_157178968_157179119	7590	0.280844	-0.81	8.0e-03	Click!
NR4A2	chr2_156698821_156698972	487737	0.005077	-0.71	3.3e-02	Click!
NR4A2	chr2_157176521_157176855	9945	0.273363	-0.68	4.5e-02	Click!
NR4A2	chr2_157177580_157177731	8978	0.275974	-0.67	4.7e-02	Click!
NR4A2	chr2_157186149_157186300	409	0.898176	-0.66	5.5e-02	Click!

Activity of the NR4A2 motif across conditions

Conditions sorted by the z-value of the NR4A2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_32718292_32718517	0.12	LCK	lymphocyte-specific protein tyrosine kinase	1529	0.2
chr1_6524907_6525205	0.11	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	634	0.58
chr11_82828119_82828301	0.11	PCF11	PCF11 cleavage and polyadenylation factor subunit	39820	0.12
chr14_100531999_100532513	0.11	EVL	Enah/Vasp-like	498	0.76
chr11_121324494_121324645	0.11	RP11-730K11.1		847	0.59
chr9_134127628_134128133	0.10	FAM78A	family with sequence similarity 78, member A	18000	0.15
chr1_198616062_198616213	0.10	PTPRC	protein tyrosine phosphatase, receptor type, C	7845	0.25
chr11_117860130_117860281	0.10	IL10RA	interleukin 10 receptor, alpha	3096	0.25
chr5_175085682_175085863	0.10	HRH2	histamine receptor H2	739	0.7
chr7_50349443_50349694	0.10	IKZF1	IKAROS family zinc finger 1 (Ikaros)	1250	0.61
chr7_106506867_106507018	0.10	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1018	0.65
chr7_8171794_8172008	0.10	AC006042.6		18246	0.2
chrX_128916701_128916852	0.10	SASH3	SAM and SH3 domain containing 3	2816	0.27
chr13_30510013_30510639	0.10	LINC00572	long intergenic non-protein coding RNA 572	9538	0.3
chr11_64511299_64511931	0.09	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	2	0.96
chr12_46611391_46611598	0.09	SLC38A1	solute carrier family 38, member 1	49990	0.18
chrX_46432402_46432561	0.09	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	738	0.71
chr14_22966248_22966484	0.09	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	10195	0.1
chr1_198611164_198611406	0.09	PTPRC	protein tyrosine phosphatase, receptor type, C	2993	0.32
chr19_39108076_39108634	0.09	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	209	0.87
chr8_66843424_66843611	0.09	PDE7A	phosphodiesterase 7A	89330	0.09
chr3_121379556_121379755	0.09	HCLS1	hematopoietic cell-specific Lyn substrate 1	90	0.96
chr19_54880943_54881230	0.09	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	972	0.39
chr7_142424483_142424634	0.09	PRSS1	protease, serine, 1 (trypsin 1)	32761	0.16
chr14_102281143_102281546	0.09	CTD-2017C7.2		4686	0.17
chr5_142177952_142178103	0.09	ARHGAP26	Rho GTPase activating protein 26	25745	0.22
chr11_65185943_65186437	0.09	ENSG00000245532	.	25739	0.09
chr10_30316643_30316960	0.09	KIAA1462	KIAA1462	31652	0.24
chr1_198617358_198617617	0.09	PTPRC	protein tyrosine phosphatase, receptor type, C	9195	0.24
chr21_35884173_35884324	0.09	KCNE1	potassium voltage-gated channel, Isk-related family, member 1	325	0.89
chr22_44391651_44392034	0.09	PARVB	parvin, beta	3249	0.27
chr14_22974214_22974379	0.09	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	18125	0.09
chr8_27237778_27238009	0.08	PTK2B	protein tyrosine kinase 2 beta	275	0.93
chr17_38483011_38483310	0.08	RARA	retinoic acid receptor, alpha	8623	0.11
chr17_38018344_38018495	0.08	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1960	0.26
chr14_22946001_22946152	0.08	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	780	0.46
chr15_75082239_75082553	0.08	ENSG00000264386	.	1298	0.27
chr17_28085184_28085335	0.08	RP11-82O19.1		2862	0.22
chr14_98443402_98443682	0.08	C14orf64	chromosome 14 open reading frame 64	841	0.77
chr7_38389126_38389277	0.08	AMPH	amphiphysin	113512	0.07
chr1_150536239_150536708	0.08	ADAMTSL4-AS1	ADAMTSL4 antisense RNA 1	2504	0.12
chr20_39768553_39768784	0.08	RP1-1J6.2		2025	0.31
chrX_128910765_128910976	0.08	SASH3	SAM and SH3 domain containing 3	3090	0.26
chr7_45016674_45016991	0.08	MYO1G	myosin IG	1865	0.25
chr17_76755792_76756034	0.08	CYTH1	cytohesin 1	22441	0.17
chrX_48772131_48772362	0.08	PIM2	pim-2 oncogene	766	0.45
chr16_88767040_88767399	0.08	RNF166	ring finger protein 166	208	0.83
chr19_3478950_3479105	0.08	C19orf77	chromosome 19 open reading frame 77	59	0.95
chr1_167602601_167602772	0.08	RP3-455J7.4		2775	0.25
chr16_81030456_81031156	0.07	CMC2	C-x(9)-C motif containing 2	1458	0.31
chr7_38389675_38390189	0.07	AMPH	amphiphysin	112781	0.07
chr20_61551174_61551325	0.07	DIDO1	death inducer-obliterator 1	5491	0.16
chr1_90074397_90074573	0.07	RP11-413E1.4		20799	0.15
chr6_144472562_144472798	0.07	STX11	syntaxin 11	1017	0.64
chr10_82259532_82259683	0.07	RP11-137H2.4		36091	0.14
chr10_52273037_52273188	0.07	RP11-512N4.2		40538	0.15
chr16_28504630_28504781	0.07	CLN3	ceroid-lipofuscinosis, neuronal 3	611	0.54
chr9_95857151_95857367	0.07	RP11-274J16.5		552	0.64
chr12_56732992_56733270	0.07	IL23A	interleukin 23, alpha subunit p19	468	0.6
chr5_39206788_39206954	0.07	FYB	FYN binding protein	3742	0.34
chr1_28974520_28974765	0.07	ENSG00000270103	.	470	0.72
chr7_38384658_38384902	0.07	AMPH	amphiphysin	117933	0.06
chr10_130834433_130834622	0.07	MGMT	O-6-methylguanine-DNA methyltransferase	430921	0.01
chr1_247573351_247573502	0.07	NLRP3	NLR family, pyrin domain containing 3	6032	0.19
chr14_55799512_55799838	0.07	RP11-665C16.5		6544	0.25
chr16_17107310_17107606	0.07	CTD-2576D5.4		120903	0.07
chr6_149415953_149416198	0.06	RP11-162J8.3		62366	0.12
chr6_14755159_14755442	0.06	ENSG00000206960	.	108534	0.08
chr13_43564402_43564714	0.06	EPSTI1	epithelial stromal interaction 1 (breast)	809	0.73
chr6_2999439_2999644	0.06	RP1-90J20.8		173	0.82
chr3_60066609_60066760	0.06	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	109101	0.08
chr18_60980797_60980948	0.06	RP11-28F1.2		443	0.81
chr4_78722448_78722599	0.06	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	17694	0.25
chr13_100308687_100308874	0.06	ENSG00000263615	.	13467	0.18
chr12_117536177_117536841	0.06	TESC	tescalcin	742	0.76
chr10_14702052_14702247	0.06	ENSG00000201766	.	3344	0.25
chr8_6131851_6132002	0.06	RP11-115C21.2		132137	0.05
chr2_99347754_99348710	0.06	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	643	0.77
chr7_142344591_142344772	0.06	MTRNR2L6	MT-RNR2-like 6	29423	0.21
chr6_57146781_57146932	0.06	PRIM2	primase, DNA, polypeptide 2 (58kDa)	35566	0.17
chr17_66288424_66288865	0.06	ARSG	arylsulfatase G	985	0.41
chr12_104854827_104855220	0.06	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	4244	0.32
chrX_3617821_3618286	0.06	PRKX	protein kinase, X-linked	13596	0.21
chr12_96502184_96502412	0.06	ENSG00000266889	.	6271	0.22
chr9_117159748_117160008	0.06	AKNA	AT-hook transcription factor	3193	0.27
chr5_137416537_137416688	0.06	WNT8A	wingless-type MMTV integration site family, member 8A	2969	0.16
chr15_64888931_64889431	0.06	ENSG00000207223	.	55906	0.09
chr18_9779691_9779842	0.06	ENSG00000242651	.	50858	0.12
chr6_34360722_34361201	0.06	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	510	0.78
chr6_25137772_25138250	0.06	ENSG00000222373	.	54630	0.11
chr9_135036030_135036181	0.06	NTNG2	netrin G2	1229	0.56
chr11_6399629_6399806	0.06	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11938	0.14
chr13_41187397_41187548	0.06	FOXO1	forkhead box O1	53262	0.14
chr10_88296004_88296305	0.06	RP11-77P6.2		14452	0.18
chr7_127749136_127749293	0.06	ENSG00000207588	.	27301	0.2
chr20_57232821_57232972	0.06	STX16	syntaxin 16	5833	0.18
chr13_33000514_33000892	0.06	N4BP2L1	NEDD4 binding protein 2-like 1	1448	0.44
chrX_69522152_69522303	0.06	KIF4A	kinesin family member 4A	12287	0.11
chr7_139929395_139929688	0.06	ENSG00000199283	.	12129	0.17
chr5_1594076_1595069	0.06	SDHAP3	succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3	1168	0.53
chr17_78619420_78619571	0.06	RPTOR	regulatory associated protein of MTOR, complex 1	100227	0.07
chrX_47489439_47489603	0.06	CFP	complement factor properdin	157	0.92
chr10_130833753_130834277	0.06	MGMT	O-6-methylguanine-DNA methyltransferase	431433	0.01
chr20_37434777_37435281	0.06	PPP1R16B	protein phosphatase 1, regulatory subunit 16B	662	0.71
chr4_185776582_185776733	0.06	ENSG00000266698	.	4393	0.22
chr1_40867584_40867735	0.06	SMAP2	small ArfGAP2	5152	0.19
chr6_57680311_57680462	0.06	ENSG00000212017	.	425456	0.01
chr12_14540053_14540282	0.06	ATF7IP	activating transcription factor 7 interacting protein	2169	0.39
chr8_53853126_53853277	0.06	NPBWR1	neuropeptides B/W receptor 1	2210	0.4
chr2_204606154_204606338	0.05	ENSG00000211573	.	23275	0.19
chr12_62658631_62659028	0.05	USP15	ubiquitin specific peptidase 15	4620	0.23
chr10_99280593_99280744	0.05	UBTD1	ubiquitin domain containing 1	22043	0.1
chr11_128380502_128380688	0.05	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	5306	0.26
chr14_78107992_78108340	0.05	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	25050	0.16
chr17_53346307_53346458	0.05	HLF	hepatic leukemia factor	1205	0.54
chr10_73521558_73521709	0.05	C10orf54	chromosome 10 open reading frame 54	4246	0.22
chr2_86079401_86079552	0.05	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	15301	0.17
chr22_39240481_39240642	0.05	NPTXR	neuronal pentraxin receptor	574	0.67
chr6_42332393_42332544	0.05	ENSG00000221252	.	47666	0.14
chr22_39417668_39418190	0.05	APOBEC3D	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	472	0.69
chr2_198651086_198651566	0.05	BOLL	boule-like RNA-binding protein	28	0.98
chr14_77422597_77423323	0.05	ENSG00000266553	.	11148	0.21
chr13_113622985_113623455	0.05	MCF2L-AS1	MCF2L antisense RNA 1	82	0.79
chr3_72788363_72788610	0.05	ENSG00000222838	.	47524	0.16
chrY_7143368_7143656	0.05	PRKY	protein kinase, Y-linked, pseudogene	1158	0.57
chr5_175960940_175961324	0.05	RNF44	ring finger protein 44	3289	0.16
chr16_745521_745735	0.05	FBXL16	F-box and leucine-rich repeat protein 16	397	0.57
chr14_69247883_69248049	0.05	ZFP36L1	ZFP36 ring finger protein-like 1	9994	0.22
chr8_53081485_53081636	0.05	RP11-26M5.3		18180	0.22
chr10_31287025_31287176	0.05	ZNF438	zinc finger protein 438	1346	0.57
chr12_47615454_47615605	0.05	PCED1B	PC-esterase domain containing 1B	1755	0.4
chr19_42705324_42705475	0.05	ENSG00000265122	.	8169	0.09
chr7_142494910_142495350	0.05	PRSS3P2	protease, serine, 3 pseudogene 2	13999	0.17
chr7_150066210_150066658	0.05	REPIN1	replication initiator 1	474	0.45
chr1_226900274_226900494	0.05	ITPKB	inositol-trisphosphate 3-kinase B	24775	0.18
chr1_19933664_19933939	0.05	MINOS1-NBL1	MINOS1-NBL1 readthrough	10240	0.13
chr6_29894399_29894823	0.05	HLA-A	major histocompatibility complex, class I, A	14426	0.18
chr6_49159531_49159682	0.05	ENSG00000252457	.	152915	0.04
chr3_45010992_45011143	0.05	ZDHHC3	zinc finger, DHHC-type containing 3	6591	0.16
chr20_48804878_48805029	0.05	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	2423	0.29
chr9_92220501_92221395	0.05	GADD45G	growth arrest and DNA-damage-inducible, gamma	995	0.69
chr1_27989094_27989245	0.05	RP11-288L9.4		6810	0.12
chr6_34191993_34192468	0.05	HMGA1	high mobility group AT-hook 1	12420	0.2
chrX_39473789_39473940	0.05	ENSG00000263730	.	46606	0.2
chr7_26345077_26345229	0.05	SNX10	sorting nexin 10	12479	0.23
chr6_56536803_56536954	0.05	DST	dystonin	29084	0.25
chr3_60061903_60062075	0.05	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	104406	0.08
chr5_56114546_56115097	0.05	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	3420	0.24
chr16_68306988_68307276	0.05	SLC7A6	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	250	0.81
chrX_134471958_134472109	0.05	ZNF75D	zinc finger protein 75D	5979	0.22
chr10_127688132_127688283	0.05	FANK1	fibronectin type III and ankyrin repeat domains 1	4221	0.25
chr10_23831077_23831228	0.05	OTUD1	OTU domain containing 1	102954	0.07
chr14_32672059_32672251	0.05	ENSG00000202337	.	320	0.8
chr6_111409779_111410127	0.05	SLC16A10	solute carrier family 16 (aromatic amino acid transporter), member 10	1172	0.45
chr3_141516104_141516959	0.05	ENSG00000265391	.	9778	0.19
chr17_73583887_73584096	0.05	MYO15B	myosin XVB pseudogene	2867	0.17
chr1_167451857_167452008	0.05	RP11-104L21.2		24034	0.18
chr19_2428027_2428178	0.05	TIMM13	translocase of inner mitochondrial membrane 13 homolog (yeast)	210	0.91
chr2_30489387_30489538	0.05	LBH	limb bud and heart development	34416	0.19
chr22_45065479_45065630	0.05	PRR5	proline rich 5 (renal)	961	0.61
chrX_46432817_46433047	0.05	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	287	0.92
chr1_28196256_28196434	0.05	THEMIS2	thymocyte selection associated family member 2	2710	0.16
chr16_71851540_71851781	0.05	AP1G1	adaptor-related protein complex 1, gamma 1 subunit	8556	0.13
chr2_109229032_109229223	0.05	LIMS1	LIM and senescent cell antigen-like domains 1	5510	0.26
chr2_170219735_170220376	0.05	LRP2	low density lipoprotein receptor-related protein 2	860	0.71
chr6_159103866_159104017	0.05	SYTL3	synaptotagmin-like 3	19746	0.18
chr21_44596901_44597052	0.05	CRYAA	crystallin, alpha A	6710	0.18
chr12_8087301_8087631	0.05	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	1316	0.38
chr14_75801482_75801633	0.05	FOS	FBJ murine osteosarcoma viral oncogene homolog	54661	0.1
chrX_1325322_1325473	0.04	CRLF2	cytokine receptor-like factor 2	6130	0.2
chr14_75807662_75807918	0.04	FOS	FBJ murine osteosarcoma viral oncogene homolog	60894	0.09
chr6_128799339_128799870	0.04	RP1-86D1.5		22068	0.14
chr21_16377585_16378233	0.04	NRIP1	nuclear receptor interacting protein 1	3220	0.28
chrX_97323503_97323654	0.04	DIAPH2-AS1	DIAPH2 antisense RNA 1	425990	0.01
chr6_166901943_166902308	0.04	ENSG00000222958	.	20796	0.16
chr12_120729183_120729407	0.04	ENSG00000202538	.	411	0.71
chrX_15874060_15874211	0.04	AP1S2	adaptor-related protein complex 1, sigma 2 subunit	1081	0.58
chr10_99080773_99080924	0.04	FRAT1	frequently rearranged in advanced T-cell lymphomas	1826	0.23
chr20_46180702_46180853	0.04	ENSG00000221294	.	18902	0.18
chr4_95698595_95698746	0.04	BMPR1B	bone morphogenetic protein receptor, type IB	19551	0.3
chrX_135961684_135962842	0.04	RBMX	RNA binding motif protein, X-linked	621	0.53
chr22_50628354_50628718	0.04	TRABD	TraB domain containing	491	0.58
chr16_71916638_71916789	0.04	RP11-498D10.3		537	0.48
chr3_73455417_73455568	0.04	PDZRN3	PDZ domain containing ring finger 3	5376	0.32
chr12_772231_772876	0.04	NINJ2	ninjurin 2	392	0.85
chr6_27106968_27108062	0.04	HIST1H4I	histone cluster 1, H4i	439	0.71
chr7_39994488_39994769	0.04	CDK13	cyclin-dependent kinase 13	4519	0.23
chrX_12997161_12997312	0.04	TMSB4X	thymosin beta 4, X-linked	3459	0.29
chr19_41309158_41309605	0.04	EGLN2	egl-9 family hypoxia-inducible factor 2	336	0.82
chr4_89743291_89743450	0.04	FAM13A	family with sequence similarity 13, member A	982	0.66
chr7_150441383_150441534	0.04	GIMAP5	GTPase, IMAP family member 5	7022	0.17
chr4_38784189_38784442	0.04	TLR10	toll-like receptor 10	264	0.9
chr9_70851276_70851465	0.04	CBWD3	COBW domain containing 3	5027	0.19
chr2_143913103_143913254	0.04	RP11-190J23.1		16563	0.23
chrX_24482692_24483178	0.04	PDK3	pyruvate dehydrogenase kinase, isozyme 3	403	0.88
chr6_169990292_169990458	0.04	WDR27	WD repeat domain 27	70413	0.1
chrY_1274756_1275442	0.04	NA	NA	> 10⁶	NA
chr8_107404618_107404769	0.04	OXR1	oxidation resistance 1	32989	0.25
chr9_116351386_116351537	0.04	RP11-168K11.2		838	0.65
chr22_25960035_25960186	0.04	CTA-407F11.8		7	0.93

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	GO:0045056	transcytosis(GO:0045056)
0.1	GO:0007172	signal complex assembly(GO:0007172)
0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	GO:0097576	vacuole fusion(GO:0097576)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)