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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for NR5A2

Z-value: 1.01

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Transcription factors associated with NR5A2

Gene Symbol	Gene ID	Gene Info
NR5A2 Ensembl NCBI GeneCards UniProt	ENSG00000116833.9	nuclear receptor subfamily 5 group A member 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr1_200003972_200004421	NR5A2	7185	0.179076	-0.59	9.2e-02	Click!
chr1_200011361_200011512	NR5A2	281	0.903812	-0.57	1.1e-01	Click!
chr1_200005044_200005195	NR5A2	6598	0.182058	-0.47	2.0e-01	Click!
chr1_200011740_200011891	NR5A2	98	0.966964	-0.44	2.3e-01	Click!
chr1_200004550_200004736	NR5A2	7074	0.179701	-0.39	3.0e-01	Click!

Activity of the NR5A2 motif across conditions

Conditions sorted by the z-value of the NR5A2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_56408975_56409725	0.98	MIR142	microRNA 142	519	0.63
chr11_65184608_65185159	0.94	ENSG00000245532	.	27046	0.09
chr14_93118654_93119048	0.78	RIN3	Ras and Rab interactor 3	5	0.99
chr9_95822109_95822464	0.77	SUSD3	sushi domain containing 3	1225	0.45
chr1_202130035_202130186	0.73	PTPN7	protein tyrosine phosphatase, non-receptor type 7	338	0.84
chr16_28996496_28996848	0.71	LAT	linker for activation of T cells	11	0.94
chr17_263385_263906	0.71	AC108004.3		169	0.93
chr16_88767040_88767399	0.65	RNF166	ring finger protein 166	208	0.83
chr17_72733506_72734386	0.61	RAB37	RAB37, member RAS oncogene family	575	0.59
chr5_175085682_175085863	0.55	HRH2	histamine receptor H2	739	0.7
chr9_117691730_117691942	0.54	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	861	0.73
chr2_113933581_113933732	0.52	AC016683.5		719	0.56
chr2_233925207_233925694	0.51	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	261	0.92
chr11_118094529_118095128	0.50	AMICA1	adhesion molecule, interacts with CXADR antigen 1	26	0.97
chr16_28997019_28997515	0.50	LAT	linker for activation of T cells	266	0.8
chr1_160680341_160680580	0.49	CD48	CD48 molecule	1133	0.45
chr11_1874347_1875032	0.48	LSP1	lymphocyte-specific protein 1	489	0.65
chr11_121324494_121324645	0.47	RP11-730K11.1		847	0.59
chr19_17958305_17958511	0.47	JAK3	Janus kinase 3	418	0.74
chr1_39681454_39681741	0.46	RP11-416A14.1		9413	0.17
chr14_76009252_76009829	0.46	BATF	basic leucine zipper transcription factor, ATF-like	20637	0.15
chr11_64511299_64511931	0.45	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	2	0.96
chr7_37486894_37487045	0.45	ELMO1	engulfment and cell motility 1	1584	0.4
chr7_50348449_50348781	0.44	IKZF1	IKAROS family zinc finger 1 (Ikaros)	297	0.94
chr17_29646389_29646953	0.43	CTD-2370N5.3		822	0.44
chr20_35272938_35273145	0.43	SLA2	Src-like-adaptor 2	1243	0.37
chr12_51712894_51713057	0.42	BIN2	bridging integrator 2	4924	0.17
chr5_176785343_176785607	0.42	RGS14	regulator of G-protein signaling 14	637	0.54
chr1_6087801_6087952	0.41	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	519	0.77
chr13_31311278_31311505	0.41	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	1746	0.48
chr19_14551433_14551660	0.41	PKN1	protein kinase N1	474	0.7
chr17_73840046_73840332	0.40	UNC13D	unc-13 homolog D (C. elegans)	226	0.84
chr19_1068460_1068611	0.40	HMHA1	histocompatibility (minor) HA-1	1038	0.32
chr21_36399790_36399994	0.40	RUNX1	runt-related transcription factor 1	21570	0.29
chr12_15113209_15113383	0.40	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	904	0.55
chr15_75082239_75082553	0.40	ENSG00000264386	.	1298	0.27
chr17_4389201_4389708	0.39	RP13-580F15.2		194	0.92
chr10_50395214_50395459	0.39	C10orf128	chromosome 10 open reading frame 128	1021	0.55
chr17_76255043_76255413	0.38	TMEM235	transmembrane protein 235	27106	0.12
chr19_54880943_54881230	0.38	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	972	0.39
chr2_47406474_47406729	0.38	CALM2	calmodulin 2 (phosphorylase kinase, delta)	2861	0.29
chr3_128835318_128835661	0.38	RAB43	RAB43, member RAS oncogene family	5135	0.13
chr19_8641491_8641716	0.37	MYO1F	myosin IF	719	0.54
chr8_134085908_134086059	0.37	SLA	Src-like-adaptor	13380	0.24
chr7_38398847_38399253	0.37	AMPH	amphiphysin	103663	0.08
chr19_39108076_39108634	0.37	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	209	0.87
chr11_117860130_117860281	0.37	IL10RA	interleukin 10 receptor, alpha	3096	0.25
chr8_19495360_19495521	0.37	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	35434	0.23
chr8_125487510_125488222	0.36	RNF139	ring finger protein 139	887	0.55
chr9_134147000_134147362	0.36	FAM78A	family with sequence similarity 78, member A	1271	0.44
chr1_198617358_198617617	0.36	PTPRC	protein tyrosine phosphatase, receptor type, C	9195	0.24
chr3_113251981_113252391	0.36	SIDT1	SID1 transmembrane family, member 1	968	0.54
chr6_27106968_27108062	0.36	HIST1H4I	histone cluster 1, H4i	439	0.71
chr19_13044658_13044845	0.35	FARSA	phenylalanyl-tRNA synthetase, alpha subunit	100	0.89
chr1_225654970_225655492	0.35	RP11-496N12.6		2186	0.34
chr5_75700240_75700391	0.35	IQGAP2	IQ motif containing GTPase activating protein 2	66	0.98
chr1_112019023_112019174	0.35	C1orf162	chromosome 1 open reading frame 162	2607	0.15
chr2_237445797_237446029	0.35	IQCA1	IQ motif containing with AAA domain 1	29728	0.19
chr11_3855665_3855911	0.35	RHOG	ras homolog family member G	3309	0.13
chr6_33043813_33044241	0.35	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	284	0.84
chr17_76755792_76756034	0.34	CYTH1	cytohesin 1	22441	0.17
chr1_167602601_167602772	0.34	RP3-455J7.4		2775	0.25
chr7_30199656_30199839	0.34	AC007036.5		2600	0.25
chr20_55967269_55967568	0.33	RBM38	RNA binding motif protein 38	132	0.89
chr1_32718292_32718517	0.33	LCK	lymphocyte-specific protein tyrosine kinase	1529	0.2
chr4_2802491_2802761	0.33	SH3BP2	SH3-domain binding protein 2	1901	0.35
chr2_237446959_237447193	0.33	ACKR3	atypical chemokine receptor 3	29354	0.19
chr16_3630185_3630336	0.32	NLRC3	NLR family, CARD domain containing 3	2859	0.2
chr8_21769513_21769765	0.32	DOK2	docking protein 2, 56kDa	1535	0.4
chr11_61786575_61786726	0.32	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	51197	0.09
chr11_47399235_47399544	0.32	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene	553	0.59
chr20_62271866_62272113	0.32	STMN3	stathmin-like 3	12130	0.09
chr1_161038546_161039545	0.32	ARHGAP30	Rho GTPase activating protein 30	411	0.65
chr1_26316819_26316970	0.31	PAFAH2	platelet-activating factor acetylhydrolase 2, 40kDa	7218	0.1
chr12_58134671_58134822	0.31	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	1194	0.21
chr16_23837804_23837955	0.31	PRKCB	protein kinase C, beta	9443	0.23
chr4_143298422_143298705	0.31	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	53849	0.19
chr2_240187102_240187645	0.31	ENSG00000265215	.	39784	0.13
chr7_150415780_150415950	0.31	GIMAP1	GTPase, IMAP family member 1	2220	0.26
chr20_328398_328906	0.31	RP5-1103G7.4		216	0.57
chr4_6928559_6928859	0.31	TBC1D14	TBC1 domain family, member 14	16734	0.16
chr19_49362364_49362642	0.31	PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	128	0.91
chr22_31685093_31685245	0.30	PIK3IP1	phosphoinositide-3-kinase interacting protein 1	3212	0.14
chr1_117299309_117299473	0.30	CD2	CD2 molecule	2302	0.33
chr7_45016674_45016991	0.30	MYO1G	myosin IG	1865	0.25
chr6_13274566_13274804	0.30	RP1-257A7.4		394	0.82
chr14_100532787_100533367	0.30	EVL	Enah/Vasp-like	303	0.88
chr19_17515989_17516450	0.30	BST2	bone marrow stromal cell antigen 2	238	0.54
chr13_46745397_46745548	0.30	ENSG00000240767	.	1589	0.32
chr6_41650642_41650943	0.30	AL035588.1		3172	0.18
chr15_52513775_52514010	0.30	GNB5	guanine nucleotide binding protein (G protein), beta 5	30326	0.14
chr5_75699014_75699893	0.30	IQGAP2	IQ motif containing GTPase activating protein 2	304	0.94
chr8_126517755_126517906	0.30	ENSG00000266452	.	61023	0.14
chr19_42705324_42705475	0.30	ENSG00000265122	.	8169	0.09
chr10_22622036_22622322	0.30	BMI1	BMI1 polycomb ring finger oncogene	6731	0.15
chr17_56416209_56416360	0.30	BZRAP1-AS1	BZRAP1 antisense RNA 1	1565	0.24
chr7_38389675_38390189	0.29	AMPH	amphiphysin	112781	0.07
chr15_34627792_34628213	0.29	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	1043	0.38
chr19_43033217_43033368	0.29	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	631	0.71
chr22_50752772_50753385	0.29	XX-C283C717.1		18	0.95
chr19_3178230_3178381	0.29	S1PR4	sphingosine-1-phosphate receptor 4	431	0.74
chr2_204804413_204804564	0.29	ICOS	inducible T-cell co-stimulator	2985	0.36
chr8_144273081_144273547	0.29	GPIHBP1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	21754	0.13
chr10_70850849_70851349	0.29	SRGN	serglycin	3225	0.25
chr13_49832065_49832609	0.29	CDADC1	cytidine and dCMP deaminase domain containing 1	10153	0.23
chr9_129233663_129234100	0.29	ENSG00000252985	.	44709	0.13
chr17_3866518_3867344	0.29	ATP2A3	ATPase, Ca++ transporting, ubiquitous	654	0.71
chr15_101782791_101782964	0.29	CHSY1	chondroitin sulfate synthase 1	9260	0.18
chr9_42914298_42914449	0.28	AC129778.2		55288	0.15
chr6_32159695_32160229	0.28	GPSM3	G-protein signaling modulator 3	683	0.42
chr19_55850633_55850856	0.28	SUV420H2	suppressor of variegation 4-20 homolog 2 (Drosophila)	477	0.39
chr11_14665333_14666638	0.28	PDE3B	phosphodiesterase 3B, cGMP-inhibited	608	0.56
chr14_22946001_22946152	0.28	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	780	0.46
chr7_961818_962008	0.28	ADAP1	ArfGAP with dual PH domains 1	1387	0.35
chr11_121327677_121327828	0.28	RP11-730K11.1		4030	0.27
chr1_151028880_151029472	0.28	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	1058	0.29
chr3_32994118_32994336	0.28	CCR4	chemokine (C-C motif) receptor 4	1161	0.6
chr9_42587473_42587624	0.28	ENSG00000266353	.	7575	0.28
chr19_42381868_42382033	0.28	CD79A	CD79a molecule, immunoglobulin-associated alpha	575	0.62
chr11_82828119_82828301	0.28	PCF11	PCF11 cleavage and polyadenylation factor subunit	39820	0.12
chr4_108615033_108615184	0.28	PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	26500	0.24
chr1_9690042_9690512	0.28	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	21513	0.15
chr8_144437169_144437484	0.28	TOP1MT	topoisomerase (DNA) I, mitochondrial	890	0.4
chrX_47489439_47489603	0.28	CFP	complement factor properdin	157	0.92
chr3_121379230_121379471	0.28	HCLS1	hematopoietic cell-specific Lyn substrate 1	395	0.81
chr9_95857151_95857367	0.28	RP11-274J16.5		552	0.64
chr22_25574447_25574657	0.28	CRYBB3	crystallin, beta B3	21265	0.19
chr6_159074554_159074705	0.28	SYTL3	synaptotagmin-like 3	3583	0.22
chr9_70851276_70851465	0.28	CBWD3	COBW domain containing 3	5027	0.19
chr3_46248309_46248460	0.27	CCR1	chemokine (C-C motif) receptor 1	1503	0.46
chr7_127749136_127749293	0.27	ENSG00000207588	.	27301	0.2
chr17_66288424_66288865	0.27	ARSG	arylsulfatase G	985	0.41
chr1_28196256_28196434	0.27	THEMIS2	thymocyte selection associated family member 2	2710	0.16
chr8_38663717_38663929	0.27	TACC1	transforming, acidic coiled-coil containing protein 1	855	0.58
chr7_2445424_2445909	0.27	CHST12	carbohydrate (chondroitin 4) sulfotransferase 12	1932	0.35
chr10_11252091_11252492	0.27	RP3-323N1.2		38952	0.17
chr16_433636_433787	0.27	TMEM8A	transmembrane protein 8A	1729	0.2
chr6_35267664_35267815	0.27	DEF6	differentially expressed in FDCP 6 homolog (mouse)	2110	0.3
chr11_64627415_64627663	0.27	CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	15498	0.09
chr5_118644168_118644319	0.27	ENSG00000243333	.	1917	0.35
chr14_102281143_102281546	0.27	CTD-2017C7.2		4686	0.17
chr5_57788132_57788386	0.27	GAPT	GRB2-binding adaptor protein, transmembrane	995	0.57
chr3_18484841_18485200	0.27	SATB1	SATB homeobox 1	1345	0.38
chr2_127838932_127839401	0.26	BIN1	bridging integrator 1	25411	0.22
chr7_2568940_2569293	0.26	ENSG00000264357	.	2408	0.22
chr9_184434_184636	0.26	CBWD1	COBW domain containing 1	5463	0.2
chrX_111125721_111125872	0.26	TRPC5OS	TRPC5 opposite strand	671	0.81
chr10_23000499_23000660	0.26	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	2458	0.4
chr14_22972981_22973242	0.26	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	16940	0.09
chr1_32719471_32719691	0.26	LCK	lymphocyte-specific protein tyrosine kinase	2706	0.13
chr11_2466894_2467127	0.26	KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	789	0.56
chr9_117149358_117150269	0.26	AKNA	AT-hook transcription factor	430	0.85
chr13_48795269_48795575	0.26	ITM2B	integral membrane protein 2B	11872	0.26
chr15_34620156_34620427	0.26	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	8754	0.11
chr3_141516104_141516959	0.26	ENSG00000265391	.	9778	0.19
chr20_44640151_44640302	0.26	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	2679	0.18
chr11_48065579_48065730	0.26	AC103828.1		28247	0.17
chr1_1830918_1831069	0.26	RP1-140A9.1		8083	0.13
chrX_129307936_129308087	0.26	RAB33A	RAB33A, member RAS oncogene family	2388	0.3
chrX_128913537_128913688	0.26	SASH3	SAM and SH3 domain containing 3	348	0.88
chrX_78402769_78403059	0.26	GPR174	G protein-coupled receptor 174	23555	0.28
chr19_7742927_7743078	0.26	CTD-3214H19.16		385	0.62
chr15_93426430_93426631	0.26	CHD2	chromodomain helicase DNA binding protein 2	4	0.98
chr8_27262752_27262933	0.25	PTK2B	protein tyrosine kinase 2 beta	7873	0.23
chr16_85981545_85981835	0.25	IRF8	interferon regulatory factor 8	33771	0.2
chr7_150329208_150329551	0.25	GIMAP6	GTPase, IMAP family member 6	55	0.98
chr16_30077190_30078018	0.25	ALDOA	aldolase A, fructose-bisphosphate	96	0.92
chr6_128221625_128221781	0.25	THEMIS	thymocyte selection associated	400	0.91
chr2_237455550_237455701	0.25	ACKR3	atypical chemokine receptor 3	20805	0.22
chr7_38385599_38385750	0.25	AMPH	amphiphysin	117039	0.06
chr11_47415900_47416112	0.25	RP11-750H9.5		1185	0.28
chr11_64108374_64108555	0.25	CCDC88B	coiled-coil domain containing 88B	769	0.4
chr12_6899553_6899934	0.25	CD4	CD4 molecule	1009	0.28
chr21_46902731_46902882	0.25	COL18A1	collagen, type XVIII, alpha 1	7383	0.21
chr3_14418723_14418874	0.25	ENSG00000199609	.	17350	0.21
chr1_226066769_226066920	0.25	TMEM63A	transmembrane protein 63A	1465	0.3
chr9_34380533_34380766	0.24	C9orf24	chromosome 9 open reading frame 24	880	0.46
chr10_99080773_99080924	0.24	FRAT1	frequently rearranged in advanced T-cell lymphomas	1826	0.23
chr14_52331779_52331930	0.24	GNG2	guanine nucleotide binding protein (G protein), gamma 2	3812	0.25
chr6_20206247_20206398	0.24	RP11-239H6.2		5996	0.24
chr6_24920420_24920571	0.24	FAM65B	family with sequence similarity 65, member B	9300	0.23
chr3_88226589_88226740	0.24	C3orf38	chromosome 3 open reading frame 38	27527	0.17
chr6_90088751_90088902	0.24	UBE2J1	ubiquitin-conjugating enzyme E2, J1	26259	0.16
chr19_6481304_6482171	0.24	DENND1C	DENN/MADD domain containing 1C	27	0.95
chr6_2840474_2840660	0.24	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	1527	0.38
chr13_99910052_99910203	0.24	GPR18	G protein-coupled receptor 18	501	0.81
chr3_196339174_196339325	0.24	LINC01063	long intergenic non-protein coding RNA 1063	20209	0.12
chr3_114010788_114010939	0.24	TIGIT	T cell immunoreceptor with Ig and ITIM domains	914	0.57
chr21_46902934_46903368	0.24	COL18A1	collagen, type XVIII, alpha 1	7038	0.21
chr12_94543232_94543438	0.24	PLXNC1	plexin C1	836	0.67
chr11_10480387_10480598	0.24	AMPD3	adenosine monophosphate deaminase 3	2195	0.31
chr2_32490543_32490694	0.24	NLRC4	NLR family, CARD domain containing 4	183	0.95
chr1_154926399_154926550	0.24	PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	2106	0.14
chr19_17860667_17860818	0.24	FCHO1	FCH domain only 1	1544	0.29
chr1_154985461_154985619	0.24	ZBTB7B	zinc finger and BTB domain containing 7B	1384	0.19
chr22_24525287_24525438	0.24	CABIN1	calcineurin binding protein 1	26444	0.14
chr16_17107310_17107606	0.24	CTD-2576D5.4		120903	0.07
chrX_131351481_131352000	0.24	RAP2C	RAP2C, member of RAS oncogene family	412	0.59
chr2_30559834_30559985	0.24	ENSG00000221377	.	95405	0.07
chr16_84628728_84628899	0.24	RP11-61F12.1		814	0.61

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR5A2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.4	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.4	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.4	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.3	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.1	0.3	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.4	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.1	0.4	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1	0.7	GO:0046645	regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.1	0.2	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.3	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0006154	adenosine catabolic process(GO:0006154)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.1	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.1	1.0	GO:0043303	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.3	GO:0032486	Rap protein signal transduction(GO:0032486)
0.1	0.2	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.1	0.3	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1	0.5	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.1	0.2	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.1	0.2	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.1	0.3	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1	0.5	GO:0045576	mast cell activation(GO:0045576)
0.1	0.3	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.1	0.2	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.1	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.1	GO:0048368	lateral mesoderm development(GO:0048368)
0.1	0.2	GO:0006177	GMP biosynthetic process(GO:0006177)
0.1	0.4	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0034063	stress granule assembly(GO:0034063)
0.1	0.4	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.1	0.3	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.1	0.2	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.1	GO:2001235	positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.2	GO:0042104	positive regulation of activated T cell proliferation(GO:0042104)
0.0	0.3	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0071218	cellular response to misfolded protein(GO:0071218)
0.0	0.3	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.3	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.4	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.2	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.2	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:1901021	activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) positive regulation of cation channel activity(GO:2001259)
0.0	0.3	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.3	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.2	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.2	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.6	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.2	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.2	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.5	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.2	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.2	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.2	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0010870	positive regulation of receptor biosynthetic process(GO:0010870)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0042772	DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.2	GO:0042094	interleukin-2 biosynthetic process(GO:0042094)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0002532	production of molecular mediator involved in inflammatory response(GO:0002532)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.2	GO:0036230	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.1	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0001916	positive regulation of T cell mediated cytotoxicity(GO:0001916)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.2	GO:0016045	detection of bacterium(GO:0016045) detection of other organism(GO:0098543)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.2	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.1	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.3	GO:0016577	histone demethylation(GO:0016577)
0.0	0.0	GO:0032418	lysosome localization(GO:0032418)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.0	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.4	GO:0007032	endosome organization(GO:0007032)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.3	GO:0006098	pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0	0.2	GO:0015884	folic acid transport(GO:0015884)
0.0	1.3	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0015919	peroxisomal membrane transport(GO:0015919)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.1	GO:0050798	activated T cell proliferation(GO:0050798)
0.0	0.3	GO:0019674	NAD metabolic process(GO:0019674)
0.0	0.1	GO:0048505	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0051156	glucose 6-phosphate metabolic process(GO:0051156)
0.0	0.1	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.0	GO:0032785	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.5	GO:0043928	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.5	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.1	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.2	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.6	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.0	GO:0045579	positive regulation of B cell differentiation(GO:0045579)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0003079	maternal aggressive behavior(GO:0002125) obsolete positive regulation of natriuresis(GO:0003079)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.2	GO:0098926	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0	0.2	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.0	GO:0009595	detection of biotic stimulus(GO:0009595)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.1	GO:0034030	coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.2	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.2	GO:0045907	positive regulation of vasoconstriction(GO:0045907)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.2	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.1	GO:1903313	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.2	GO:0030330	DNA damage response, signal transduction by p53 class mediator(GO:0030330)
0.0	0.1	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.0	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0046688	response to copper ion(GO:0046688)
0.0	0.3	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.0	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.0	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0010821	regulation of mitochondrion organization(GO:0010821)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.1	GO:0033363	secretory granule organization(GO:0033363)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0001706	endoderm formation(GO:0001706)
0.0	0.1	GO:0045730	respiratory burst(GO:0045730)
0.0	0.1	GO:0051974	negative regulation of telomerase activity(GO:0051974)
0.0	0.3	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0	0.1	GO:0006105	succinate metabolic process(GO:0006105)
0.0	0.0	GO:0015853	adenine transport(GO:0015853)
0.0	0.6	GO:0006968	cellular defense response(GO:0006968)
0.0	0.0	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.1	GO:1904894	positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:1901678	iron coordination entity transport(GO:1901678)
0.0	0.8	GO:2000134	negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	1.2	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.1	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.1	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.1	GO:0090003	regulation of establishment of protein localization to plasma membrane(GO:0090003) regulation of protein localization to plasma membrane(GO:1903076) regulation of protein localization to cell periphery(GO:1904375)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.3	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.1	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.0	0.1	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881)
0.0	0.0	GO:0031497	chromatin assembly(GO:0031497)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.2	GO:0001504	neurotransmitter uptake(GO:0001504) import into cell(GO:0098657)
0.0	0.1	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.0	GO:0034382	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.4	GO:0051607	defense response to virus(GO:0051607)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.0	0.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.4	GO:0006333	chromatin assembly or disassembly(GO:0006333)
0.0	0.0	GO:0016265	obsolete death(GO:0016265)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0010755	regulation of plasminogen activation(GO:0010755)
0.0	0.0	GO:0042102	positive regulation of T cell proliferation(GO:0042102)
0.0	0.0	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.1	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.1	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0	0.1	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.0	0.9	GO:0022904	respiratory electron transport chain(GO:0022904)
0.0	0.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.4	GO:0030521	androgen receptor signaling pathway(GO:0030521)
0.0	0.1	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.5	GO:0006914	autophagy(GO:0006914)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.1	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.2	GO:0043487	regulation of RNA stability(GO:0043487)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:1901070	guanosine-containing compound biosynthetic process(GO:1901070)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.0	0.1	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.1	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.1	GO:0015669	gas transport(GO:0015669)
0.0	0.0	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.0	GO:0001820	serotonin secretion(GO:0001820)
0.0	0.1	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.0	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.2	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0034375	high-density lipoprotein particle remodeling(GO:0034375)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	1.4	GO:0001772	immunological synapse(GO:0001772)
0.1	0.5	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.4	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.2	GO:0000124	SAGA complex(GO:0000124)
0.1	0.2	GO:0042629	mast cell granule(GO:0042629)
0.1	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0045273	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.2	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.5	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.2	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.0	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.3	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	1.1	GO:0000786	nucleosome(GO:0000786)
0.0	0.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.0	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	1.8	GO:0005769	early endosome(GO:0005769)
0.0	0.1	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	1.5	GO:0005770	late endosome(GO:0005770)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.8	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0031045	dense core granule(GO:0031045)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.0	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.1	GO:0055037	recycling endosome(GO:0055037)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.0	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.0	GO:0038201	TOR complex(GO:0038201)
0.0	0.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.6	GO:0070469	respiratory chain(GO:0070469)
0.0	1.1	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.0	0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.0	GO:0001939	female pronucleus(GO:0001939)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2	0.5	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.4	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.4	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	0.3	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.4	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.3	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.6	GO:0005522	profilin binding(GO:0005522)
0.1	0.4	GO:0004969	histamine receptor activity(GO:0004969)
0.1	0.2	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.1	0.2	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.4	GO:0050700	CARD domain binding(GO:0050700)
0.1	0.3	GO:0001727	lipid kinase activity(GO:0001727)
0.1	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.5	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.2	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.2	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.6	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.2	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.3	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.3	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.3	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.3	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	1.9	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.2	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0048156	tau protein binding(GO:0048156)
0.0	0.6	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.8	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.0	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.2	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.0	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.0	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.2	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.3	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.2	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.3	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.3	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.2	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0005416	sodium:amino acid symporter activity(GO:0005283) cation:amino acid symporter activity(GO:0005416)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.2	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.0	GO:0019956	chemokine binding(GO:0019956)
0.0	0.1	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.2	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.3	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.0	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.1	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.4	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.5	GO:0003678	DNA helicase activity(GO:0003678)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.3	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	1.0	GO:0017016	Ras GTPase binding(GO:0017016)
0.0	0.1	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.0	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.2	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.2	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.2	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.2	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	0.6	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	0.8	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	0.5	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.1	2.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.5	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.5	PID EPO PATHWAY	EPO signaling pathway
0.0	1.2	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.6	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.4	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.1	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.5	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	0.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.2	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.2	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.2	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.0	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.3	PID FOXO PATHWAY	FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.7	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.8	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	1.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.5	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	1.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.5	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.5	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.6	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.5	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	1.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.4	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	1.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.7	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.2	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.3	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.0	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.0	0.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	1.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.6	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.4	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.0	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	1.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.3	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.6	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.0	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.0	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	Genes involved in Signaling by the B Cell Receptor (BCR)
0.0	0.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.3	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.2	REACTOME TRNA AMINOACYLATION	Genes involved in tRNA Aminoacylation
0.0	0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.0	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)

Results for NR5A2

Z-value: 1.01

Motif logo

Transcription factors associated with NR5A2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the NR5A2 motif across conditions

Conditions sorted by the z-value of the NR5A2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR5A2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: