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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NR6A1

Z-value: 1.25

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Transcription factors associated with NR6A1

Gene Symbol	Gene ID	Gene Info
NR6A1 Ensembl NCBI GeneCards UniProt	ENSG00000148200.12	NR6A1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NR6A1	chr9_127355583_127355734	2429	0.272081	-0.24	5.3e-01	Click!
NR6A1	chr9_127533110_127533927	38	0.950296	-0.23	5.4e-01	Click!
NR6A1	chr9_127355961_127356112	2051	0.304428	0.12	7.6e-01	Click!
NR6A1	chr9_127534048_127534335	602	0.620366	0.09	8.1e-01	Click!

Activity of the NR6A1 motif across conditions

Conditions sorted by the z-value of the NR6A1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_1874347_1875032	0.94	LSP1	lymphocyte-specific protein 1	489	0.65
chr2_143886988_143887259	0.45	ARHGAP15	Rho GTPase activating protein 15	240	0.95
chr5_175085682_175085863	0.44	HRH2	histamine receptor H2	739	0.7
chr1_161038546_161039545	0.42	ARHGAP30	Rho GTPase activating protein 30	411	0.65
chr8_134085908_134086059	0.41	SLA	Src-like-adaptor	13380	0.24
chr1_207244470_207244690	0.41	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	6231	0.14
chr5_70315966_70316295	0.40	NAIP	NLR family, apoptosis inhibitory protein	407	0.88
chr6_159465378_159465638	0.38	TAGAP	T-cell activation RhoGTPase activating protein	542	0.78
chr2_30454378_30455881	0.38	LBH	limb bud and heart development	83	0.98
chrX_39968386_39969319	0.38	BCOR	BCL6 corepressor	12196	0.31
chrX_111125721_111125872	0.37	TRPC5OS	TRPC5 opposite strand	671	0.81
chr11_65343661_65344993	0.37	EHBP1L1	EH domain binding protein 1-like 1	810	0.36
chr7_36653532_36653683	0.37	AOAH-IT1	AOAH intronic transcript 1 (non-protein coding)	13881	0.19
chrX_12929174_12929325	0.37	TLR8-AS1	TLR8 antisense RNA 1	2797	0.26
chr8_61824618_61824780	0.35	RP11-33I11.2		102534	0.08
chr16_3306416_3306567	0.35	MEFV	Mediterranean fever	96	0.94
chr10_70847938_70848765	0.35	SRGN	serglycin	477	0.82
chr19_2290395_2291381	0.34	LINGO3	leucine rich repeat and Ig domain containing 3	1135	0.28
chr3_14442430_14442581	0.34	SLC6A6	solute carrier family 6 (neurotransmitter transporter), member 6	1571	0.43
chr3_46140245_46140452	0.34	CCR3	chemokine (C-C motif) receptor 3	64748	0.1
chr7_50246497_50246648	0.33	AC020743.2		64153	0.12
chr19_17958305_17958511	0.33	JAK3	Janus kinase 3	418	0.74
chr20_1926522_1926673	0.33	RP4-684O24.5		1295	0.5
chrX_153190817_153191535	0.33	ARHGAP4	Rho GTPase activating protein 4	522	0.6
chr19_52268680_52268969	0.32	FPR2	formyl peptide receptor 2	2807	0.17
chr6_126069184_126070625	0.32	RP11-624M8.1		428	0.68
chr15_81594027_81594306	0.32	IL16	interleukin 16	2409	0.29
chr4_70626143_70626357	0.32	SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	66	0.98
chr1_159823893_159825316	0.32	C1orf204	chromosome 1 open reading frame 204	533	0.6
chr2_54808515_54808696	0.32	SPTBN1	spectrin, beta, non-erythrocytic 1	23074	0.17
chr1_61332602_61332753	0.31	NFIA	nuclear factor I/A	1746	0.51
chr17_47467788_47467939	0.31	RP11-1079K10.4		13580	0.11
chr6_138002128_138002279	0.31	ENSG00000216097	.	35882	0.2
chr1_161641257_161641408	0.31	RP11-25K21.1		3282	0.14
chr21_44819752_44820164	0.31	SIK1	salt-inducible kinase 1	27050	0.24
chr13_114271369_114271520	0.31	TFDP1	transcription factor Dp-1	31703	0.15
chr6_144471049_144472508	0.30	STX11	syntaxin 11	115	0.98
chr1_192780744_192780895	0.30	RGS2	regulator of G-protein signaling 2, 24kDa	2648	0.37
chr12_109025614_109025806	0.30	SELPLG	selectin P ligand	144	0.94
chr17_29646389_29646953	0.30	CTD-2370N5.3		822	0.44
chr1_1830918_1831069	0.30	RP1-140A9.1		8083	0.13
chr2_47406474_47406729	0.30	CALM2	calmodulin 2 (phosphorylase kinase, delta)	2861	0.29
chr12_123367208_123367359	0.30	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	7423	0.17
chr1_161559432_161559583	0.30	FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	5836	0.13
chr4_88786510_88786661	0.29	MEPE	matrix extracellular phosphoglycoprotein	32446	0.16
chr2_58694154_58694305	0.29	FANCL	Fanconi anemia, complementation group L	225722	0.02
chr12_8692426_8692577	0.29	CLEC4E	C-type lectin domain family 4, member E	650	0.65
chr20_60760834_60760985	0.29	MTG2	mitochondrial ribosome-associated GTPase 2	2802	0.2
chr7_130567596_130567747	0.29	ENSG00000226380	.	5373	0.29
chr6_144981294_144981445	0.29	UTRN	utrophin	389	0.93
chr9_75567665_75568017	0.29	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	130	0.98
chr2_152779879_152780030	0.29	CACNB4	calcium channel, voltage-dependent, beta 4 subunit	48548	0.17
chr7_50257083_50257268	0.28	AC020743.2		74756	0.1
chr19_42301375_42301526	0.28	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	365	0.8
chr2_232479090_232479920	0.28	C2orf57	chromosome 2 open reading frame 57	21930	0.15
chr14_93118654_93119048	0.28	RIN3	Ras and Rab interactor 3	5	0.99
chr17_34435571_34435722	0.28	ENSG00000263488	.	1897	0.18
chr16_88768022_88768436	0.28	RNF166	ring finger protein 166	1218	0.22
chr21_39645775_39646073	0.28	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	1495	0.53
chr4_15081994_15082145	0.28	ENSG00000199420	.	13649	0.24
chr1_232715037_232715188	0.28	SIPA1L2	signal-induced proliferation-associated 1 like 2	17808	0.28
chr15_69073260_69073411	0.28	ENSG00000265195	.	20929	0.21
chr10_6243545_6244657	0.27	RP11-414H17.5		555	0.52
chr14_56588992_56589252	0.27	PELI2	pellino E3 ubiquitin protein ligase family member 2	3295	0.31
chr7_140681725_140681876	0.27	MRPS33	mitochondrial ribosomal protein S33	32429	0.17
chr6_5084934_5086227	0.27	PPP1R3G	protein phosphatase 1, regulatory subunit 3G	140	0.97
chr17_72517580_72517731	0.27	CD300LB	CD300 molecule-like family member b	9950	0.14
chr10_14920855_14921866	0.27	SUV39H2	suppressor of variegation 3-9 homolog 2 (Drosophila)	439	0.82
chr8_142131426_142131715	0.27	DENND3	DENN/MADD domain containing 3	4193	0.23
chr2_233925207_233925694	0.27	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	261	0.92
chr5_131798996_131799147	0.27	ENSG00000202533	.	4768	0.15
chr13_49788937_49789202	0.27	MLNR	motilin receptor	5405	0.25
chr19_17517338_17517489	0.27	MVB12A	multivesicular body subunit 12A	459	0.54
chr17_36861833_36863162	0.27	CTB-58E17.3		17	0.9
chr15_80253251_80253402	0.27	BCL2A1	BCL2-related protein A1	10185	0.17
chr2_135051969_135052120	0.27	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	40214	0.19
chr16_28997019_28997515	0.27	LAT	linker for activation of T cells	266	0.8
chr8_56824063_56824214	0.27	ENSG00000216204	.	2618	0.21
chr10_35424848_35424999	0.26	ENSG00000253054	.	552	0.66
chr9_101871320_101871471	0.26	TGFBR1	transforming growth factor, beta receptor 1	3963	0.26
chr12_66635842_66635993	0.26	ENSG00000266539	.	6515	0.17
chr1_44534212_44534363	0.26	SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	37153	0.11
chr11_78646693_78646844	0.26	TENM4	teneurin transmembrane protein 4	31837	0.2
chr2_162270607_162270758	0.26	TBR1	T-box, brain, 1	1923	0.3
chr1_234746129_234746973	0.26	IRF2BP2	interferon regulatory factor 2 binding protein 2	1280	0.44
chr17_75868336_75868487	0.26	FLJ45079		10248	0.24
chr2_84678068_84678219	0.26	SUCLG1	succinate-CoA ligase, alpha subunit	8461	0.29
chr2_70269953_70270104	0.26	PCBP1-AS1	PCBP1 antisense RNA 1	10889	0.17
chr21_15917916_15918619	0.26	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr20_33871790_33873092	0.26	EIF6	eukaryotic translation initiation factor 6	77	0.88
chr19_15760987_15761138	0.26	CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	8943	0.18
chr7_31851156_31851370	0.26	ENSG00000223070	.	17401	0.29
chr2_69002223_69002932	0.26	ARHGAP25	Rho GTPase activating protein 25	505	0.84
chr6_159074554_159074705	0.25	SYTL3	synaptotagmin-like 3	3583	0.22
chr1_17630308_17630459	0.25	PADI4	peptidyl arginine deiminase, type IV	4307	0.19
chr16_81867856_81868007	0.25	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	48943	0.17
chrX_12925475_12925626	0.25	TLR8	toll-like receptor 8	792	0.45
chr17_46565994_46566145	0.25	ENSG00000206805	.	9610	0.12
chr6_37140965_37141167	0.25	PIM1	pim-1 oncogene	3087	0.24
chr9_127024548_127024933	0.25	RP11-121A14.3		415	0.67
chr18_43785413_43785564	0.25	C18orf25	chromosome 18 open reading frame 25	31488	0.18
chr22_23561758_23561909	0.25	BCR	breakpoint cluster region	34314	0.12
chr11_112192338_112192489	0.25	ENSG00000206772	.	30972	0.14
chr12_15113209_15113383	0.25	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	904	0.55
chr20_54989282_54989551	0.25	CASS4	Cas scaffolding protein family member 4	2099	0.24
chr22_22216989_22217140	0.25	MAPK1	mitogen-activated protein kinase 1	4666	0.18
chr2_43439997_43440275	0.25	ZFP36L2	ZFP36 ring finger protein-like 2	13612	0.23
chr10_129860321_129860472	0.25	PTPRE	protein tyrosine phosphatase, receptor type, E	14562	0.26
chr1_9299570_9299924	0.24	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	156	0.96
chr7_44079644_44080725	0.24	RASA4CP	RAS p21 protein activator 4C, pseudogene	1307	0.26
chr13_40976108_40976619	0.24	ENSG00000252812	.	5214	0.32
chr7_36642261_36642412	0.24	AOAH-IT1	AOAH intronic transcript 1 (non-protein coding)	2610	0.28
chrX_13108426_13108692	0.24	FAM9C	family with sequence similarity 9, member C	45758	0.18
chr16_53404692_53404843	0.24	RP11-44F14.1		2228	0.28
chr12_92523772_92523923	0.24	C12orf79	chromosome 12 open reading frame 79	6950	0.19
chr1_27438843_27438994	0.24	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	42055	0.13
chr16_75661718_75661869	0.24	ADAT1	adenosine deaminase, tRNA-specific 1	4595	0.16
chr2_99080716_99081105	0.24	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	19497	0.22
chr12_116996820_116997035	0.24	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	259	0.95
chr6_11330504_11330655	0.24	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	51953	0.16
chr4_185741986_185742137	0.24	ACSL1	acyl-CoA synthetase long-chain family member 1	5127	0.2
chr1_36840428_36840700	0.24	STK40	serine/threonine kinase 40	10921	0.12
chr7_134845732_134845901	0.24	RP11-134L10.1		7339	0.14
chr17_56408975_56409725	0.24	MIR142	microRNA 142	519	0.63
chr20_25554452_25554603	0.23	NINL	ninein-like	11626	0.18
chr11_44590165_44590737	0.23	CD82	CD82 molecule	3178	0.29
chr22_35725770_35725921	0.23	ENSG00000266320	.	5788	0.17
chr19_54881402_54882266	0.23	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	224	0.88
chr11_104914233_104914622	0.23	CARD16	caspase recruitment domain family, member 16	1607	0.35
chr5_130588828_130589214	0.23	CDC42SE2	CDC42 small effector 2	10681	0.28
chr2_96923789_96923942	0.23	TMEM127	transmembrane protein 127	2468	0.21
chr5_118646029_118646180	0.23	ENSG00000243333	.	3778	0.24
chr15_85141845_85142241	0.23	ZSCAN2	zinc finger and SCAN domain containing 2	2174	0.19
chr5_133860075_133861084	0.23	JADE2	jade family PHD finger 2	576	0.71
chr3_48259036_48259187	0.23	CAMP	cathelicidin antimicrobial peptide	5726	0.13
chr10_12307829_12307980	0.23	ENSG00000265824	.	4234	0.18
chr2_237884098_237884249	0.23	ENSG00000202341	.	39775	0.18
chr12_122230893_122231238	0.23	RHOF	ras homolog family member F (in filopodia)	201	0.93
chr13_46743875_46744026	0.23	ENSG00000240767	.	67	0.96
chr12_56963795_56963946	0.23	ENSG00000201579	.	18432	0.12
chr14_105527834_105528220	0.23	GPR132	G protein-coupled receptor 132	3740	0.23
chr19_54891617_54891768	0.23	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	9527	0.1
chr2_175498427_175499207	0.23	WIPF1	WAS/WASL interacting protein family, member 1	490	0.83
chrY_15016828_15017148	0.22	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	246	0.96
chr8_61821706_61823076	0.22	RP11-33I11.2		100226	0.08
chr22_22215698_22215849	0.22	MAPK1	mitogen-activated protein kinase 1	5957	0.17
chr11_3744283_3744434	0.22	ENSG00000251934	.	8253	0.12
chr1_198978699_198978850	0.22	ENSG00000207759	.	150492	0.04
chrX_19884431_19884582	0.22	SH3KBP1	SH3-domain kinase binding protein 1	21071	0.24
chr2_112196931_112197265	0.22	ENSG00000266139	.	118430	0.07
chr20_3694963_3695114	0.22	SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	7263	0.14
chr11_116857425_116857669	0.22	ENSG00000264344	.	28698	0.13
chr5_55711467_55711618	0.22	ENSG00000265665	.	41423	0.16
chr1_26954743_26954935	0.22	ENSG00000238316	.	14041	0.13
chr16_53552293_53552836	0.22	AKTIP	AKT interacting protein	14241	0.21
chr5_55777832_55777983	0.22	CTC-236F12.4	Uncharacterized protein	311	0.91
chr12_120670116_120670490	0.22	PXN	paxillin	5656	0.13
chr6_42009511_42009971	0.22	CCND3	cyclin D3	6683	0.16
chr17_57074891_57075042	0.22	ENSG00000216168	.	8651	0.16
chr7_129666009_129666160	0.22	ENSG00000201109	.	1033	0.43
chr16_28204366_28204526	0.22	ENSG00000200138	.	9807	0.17
chrY_21906454_21906814	0.22	KDM5D	lysine (K)-specific demethylase 5D	13	0.99
chr17_43301591_43301923	0.22	CTD-2020K17.1		2168	0.16
chr13_100630550_100631126	0.22	ZIC2	Zic family member 2	3188	0.24
chr10_81959862_81960013	0.22	ANXA11	annexin A11	4310	0.24
chr6_90088751_90088902	0.22	UBE2J1	ubiquitin-conjugating enzyme E2, J1	26259	0.16
chr2_68963054_68963510	0.21	ARHGAP25	Rho GTPase activating protein 25	1268	0.56
chr1_231748956_231749347	0.21	LINC00582	long intergenic non-protein coding RNA 582	1315	0.46
chr7_90224844_90225183	0.21	AC002456.2		49	0.94
chr13_99227754_99228977	0.21	STK24	serine/threonine kinase 24	752	0.54
chr19_42082862_42083083	0.21	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	371	0.84
chr9_134147000_134147362	0.21	FAM78A	family with sequence similarity 78, member A	1271	0.44
chr9_113838212_113838363	0.21	ENSG00000212409	.	21406	0.22
chrX_100640419_100640710	0.21	BTK	Bruton agammaglobulinemia tyrosine kinase	603	0.58
chr7_142919179_142919330	0.21	AC073342.1	HCG2002387; Uncharacterized protein	106	0.51
chr19_52154438_52154589	0.21	SIGLEC5	sialic acid binding Ig-like lectin 5	4362	0.12
chr19_18586594_18586745	0.21	ELL	elongation factor RNA polymerase II	74	0.95
chr14_90526445_90527696	0.21	KCNK13	potassium channel, subfamily K, member 13	1039	0.63
chr11_34378633_34379465	0.21	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	247	0.95
chrX_39964334_39965624	0.21	BCOR	BCL6 corepressor	8323	0.32
chr12_40551802_40551953	0.21	LRRK2	leucine-rich repeat kinase 2	38669	0.17
chr2_102609202_102609353	0.21	IL1R2	interleukin 1 receptor, type II	971	0.66
chr10_11758024_11758175	0.21	ECHDC3	enoyl CoA hydratase domain containing 3	26266	0.21
chr19_2619419_2619570	0.21	CTC-265F19.2		7634	0.14
chr16_18816680_18816831	0.21	RP11-1035H13.2		2350	0.2
chr8_42742851_42743002	0.21	ENSG00000242719	.	6547	0.13
chr16_68027365_68027982	0.20	DPEP2	dipeptidase 2	93	0.9
chr1_174937099_174937250	0.20	RABGAP1L	RAB GTPase activating protein 1-like	3269	0.19
chr9_100807481_100807632	0.20	NANS	N-acetylneuraminic acid synthase	11465	0.16
chr1_204482801_204482952	0.20	MDM4	Mdm4 p53 binding protein homolog (mouse)	2635	0.26
chr7_50345445_50345596	0.20	IKZF1	IKAROS family zinc finger 1 (Ikaros)	1142	0.64
chr10_70092145_70093579	0.20	PBLD	phenazine biosynthesis-like protein domain containing	56	0.95
chr19_42705923_42706118	0.20	ENSG00000265122	.	8790	0.09
chr10_21502036_21502187	0.20	NEBL-AS1	NEBL antisense RNA 1	38828	0.16
chr1_206747757_206747908	0.20	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	17339	0.15
chr19_54899574_54899725	0.20	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	17484	0.09
chr11_63370704_63370855	0.20	PLA2G16	phospholipase A2, group XVI	5274	0.15
chr1_54946073_54946224	0.20	ENSG00000265404	.	24193	0.16
chr3_119041182_119042341	0.20	ARHGAP31-AS1	ARHGAP31 antisense RNA 1	154	0.94
chr2_103052502_103052757	0.20	AC007278.2		2212	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR6A1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.3	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.6	GO:0009812	flavonoid metabolic process(GO:0009812)
0.1	0.2	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.1	0.4	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.2	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	0.2	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.1	0.3	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.1	0.3	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.1	0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	0.2	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0061647	histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0	0.6	GO:0002279	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.3	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.2	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.1	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0032493	response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0	0.3	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.2	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0035067	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0033003	regulation of mast cell activation(GO:0033003)
0.0	0.1	GO:0031620	regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0	0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	1.1	GO:0006968	cellular defense response(GO:0006968)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.2	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:1904019	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0002532	production of molecular mediator involved in inflammatory response(GO:0002532)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.2	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	0.1	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0032615	interleukin-12 production(GO:0032615)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.1	GO:0006726	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.4	GO:0006692	prostanoid metabolic process(GO:0006692)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.0	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.1	GO:0002921	negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.2	GO:0050702	interleukin-1 beta secretion(GO:0050702)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.0	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.0	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.3	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.0	GO:0001820	serotonin secretion(GO:0001820)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.0	GO:0002643	regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0045576	mast cell activation(GO:0045576)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0006837	serotonin transport(GO:0006837)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.2	GO:0006027	glycosaminoglycan catabolic process(GO:0006027)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.2	GO:0042255	ribosome assembly(GO:0042255)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0002097	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.7	GO:0006914	autophagy(GO:0006914)
0.0	0.0	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0014002	astrocyte development(GO:0014002)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.0	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:1902305	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0043049	otic placode formation(GO:0043049)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.0	GO:1904063	negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.0	GO:0046149	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0009133	nucleoside diphosphate biosynthetic process(GO:0009133)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0021853	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.0	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.2	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0042629	mast cell granule(GO:0042629)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.4	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.0	GO:0030904	retromer complex(GO:0030904)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0070081	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.2	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.2	GO:0008023	transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.1	0.3	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.3	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.2	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	0.4	GO:0004969	histamine receptor activity(GO:0004969)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.2	GO:0004875	complement receptor activity(GO:0004875)
0.1	0.4	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.1	0.2	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.4	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.6	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.3	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.2	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.3	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.4	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.2	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.3	GO:0043022	ribosome binding(GO:0043022)
0.0	0.0	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.3	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.1	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.3	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.0	GO:0019956	chemokine binding(GO:0019956)
0.0	0.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0033612	receptor serine/threonine kinase binding(GO:0033612)
0.0	0.1	GO:0035240	dopamine binding(GO:0035240)
0.0	0.2	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4	PID IL5 PATHWAY	IL5-mediated signaling events
1.3	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.3	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.6	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.4	SIG CHEMOTAXIS	Genes related to chemotaxis
0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.6	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.0	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.4	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.8	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.4	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.1	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.5	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels