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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for OLIG1

Z-value: 0.60

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Transcription factors associated with OLIG1

Gene Symbol	Gene ID	Gene Info
OLIG1 Ensembl NCBI GeneCards UniProt	ENSG00000184221.8	OLIG1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
OLIG1	chr21_34437191_34437342	5184	0.189671	-0.44	2.4e-01	Click!
OLIG1	chr21_34439565_34439843	2746	0.235935	-0.42	2.7e-01	Click!
OLIG1	chr21_34431903_34432054	10472	0.170916	-0.37	3.3e-01	Click!
OLIG1	chr21_34431477_34431628	10898	0.170100	0.33	3.8e-01	Click!
OLIG1	chr21_34428465_34428616	13910	0.164800	-0.33	3.9e-01	Click!

Activity of the OLIG1 motif across conditions

Conditions sorted by the z-value of the OLIG1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_128913998_128914362	0.39	SASH3	SAM and SH3 domain containing 3	220	0.94
chr1_25254983_25255134	0.36	RUNX3	runt-related transcription factor 3	554	0.81
chr19_42056193_42056486	0.35	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	453	0.8
chr1_185283352_185283831	0.33	IVNS1ABP	influenza virus NS1A binding protein	2870	0.28
chr12_62657019_62657170	0.31	USP15	ubiquitin specific peptidase 15	2885	0.26
chr1_248729435_248729591	0.30	RP11-438F14.3		3612	0.13
chr1_84610455_84610717	0.30	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	632	0.82
chr5_162930555_162931177	0.30	MAT2B	methionine adenosyltransferase II, beta	746	0.62
chr2_127415089_127415240	0.30	GYPC	glycophorin C (Gerbich blood group)	1404	0.55
chr12_57077777_57078354	0.29	PTGES3	prostaglandin E synthase 3 (cytosolic)	3881	0.14
chr14_53593743_53594005	0.29	DDHD1	DDHD domain containing 1	22930	0.17
chr13_43564402_43564714	0.29	EPSTI1	epithelial stromal interaction 1 (breast)	809	0.73
chr8_66863582_66864279	0.29	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	69865	0.12
chr2_241630055_241630353	0.29	AQP12A	aquaporin 12A	1058	0.43
chr13_46754554_46754849	0.28	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	1758	0.31
chr1_248644857_248645289	0.28	RP11-407H12.8		3712	0.13
chr10_28656896_28657047	0.28	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	33556	0.16
chr5_171612568_171612893	0.28	STK10	serine/threonine kinase 10	2660	0.27
chr3_67735991_67736422	0.27	SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	31168	0.25
chr1_25875695_25876149	0.27	LDLRAP1	low density lipoprotein receptor adaptor protein 1	5851	0.23
chr11_118087619_118088223	0.27	AMICA1	adhesion molecule, interacts with CXADR antigen 1	2315	0.23
chr7_2739070_2739221	0.27	AMZ1	archaelysin family metallopeptidase 1	11309	0.21
chr17_263982_264133	0.27	AC108004.3		243	0.89
chr18_9138515_9138757	0.26	ANKRD12	ankyrin repeat domain 12	1075	0.42
chr13_52396131_52396530	0.26	RP11-327P2.5		17897	0.18
chr22_24824729_24824978	0.26	ADORA2A	adenosine A2a receptor	1323	0.44
chr4_89534455_89534711	0.26	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	7638	0.19
chr12_9806335_9806486	0.26	RP11-705C15.2		131	0.93
chr2_182325663_182326116	0.26	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	3734	0.36
chr8_66751756_66751954	0.26	PDE7A	phosphodiesterase 7A	872	0.73
chr5_148189087_148189390	0.26	ADRB2	adrenoceptor beta 2, surface	16918	0.25
chr16_29674660_29674967	0.25	QPRT	quinolinate phosphoribosyltransferase	213	0.51
chr16_10971555_10971960	0.25	CIITA	class II, major histocompatibility complex, transactivator	690	0.64
chr17_38719353_38719597	0.25	CCR7	chemokine (C-C motif) receptor 7	2210	0.28
chr1_26872331_26872899	0.25	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	272	0.88
chr11_14668160_14668311	0.25	PDE3B	phosphodiesterase 3B, cGMP-inhibited	2858	0.29
chr20_24046827_24047099	0.25	GGTLC1	gamma-glutamyltransferase light chain 1	77547	0.11
chr6_135408926_135409077	0.24	HBS1L	HBS1-like (S. cerevisiae)	15193	0.21
chr17_35860978_35861129	0.24	DUSP14	dual specificity phosphatase 14	8928	0.19
chr7_26895188_26895339	0.24	SKAP2	src kinase associated phosphoprotein 2	1976	0.43
chr5_43310867_43311162	0.24	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	2312	0.32
chr14_61814847_61814998	0.23	PRKCH	protein kinase C, eta	313	0.91
chr6_159465378_159465638	0.23	TAGAP	T-cell activation RhoGTPase activating protein	542	0.78
chr12_53616534_53616822	0.23	RARG	retinoic acid receptor, gamma	2481	0.17
chr14_90086040_90086276	0.23	FOXN3	forkhead box N3	665	0.59
chr14_22978649_22978851	0.23	TRAJ15	T cell receptor alpha joining 15	19830	0.09
chr13_50114703_50115207	0.23	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	26504	0.17
chr17_10603321_10603720	0.23	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent	2609	0.18
chr4_6677782_6677978	0.23	AC093323.1	Uncharacterized protein	16309	0.14
chr3_16330847_16330998	0.23	OXNAD1	oxidoreductase NAD-binding domain containing 1	20174	0.15
chr6_153321108_153321259	0.23	MTRF1L	mitochondrial translational release factor 1-like	2637	0.24
chr2_158291882_158292250	0.23	CYTIP	cytohesin 1 interacting protein	3860	0.26
chr17_74188552_74188703	0.23	RNF157	ring finger protein 157	25464	0.11
chr1_169672728_169672969	0.22	SELL	selectin L	7991	0.2
chr4_6753172_6753335	0.22	KIAA0232	KIAA0232	31116	0.13
chr20_35575234_35575857	0.22	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr13_97879341_97880219	0.22	MBNL2	muscleblind-like splicing regulator 2	5171	0.33
chrX_118811810_118811961	0.22	SEPT6	septin 6	14907	0.16
chr5_134712559_134712710	0.22	H2AFY	H2A histone family, member Y	22267	0.15
chr4_143325352_143326244	0.22	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	26614	0.28
chr4_40199107_40199293	0.22	RHOH	ras homolog family member H	673	0.73
chrX_53741093_53741244	0.22	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	27495	0.23
chr14_98443744_98443895	0.21	C14orf64	chromosome 14 open reading frame 64	564	0.87
chr1_23668742_23669298	0.21	HNRNPR	heterogeneous nuclear ribonucleoprotein R	1735	0.29
chr10_121352939_121353112	0.21	TIAL1	TIA1 cytotoxic granule-associated RNA binding protein-like 1	2982	0.3
chr7_150414088_150414577	0.21	GIMAP1	GTPase, IMAP family member 1	687	0.65
chr10_13828862_13829013	0.21	RP11-353M9.1		57554	0.1
chr1_229642144_229642295	0.21	NUP133	nucleoporin 133kDa	1854	0.24
chr14_64974613_64974785	0.21	ZBTB25	zinc finger and BTB domain containing 25	2768	0.16
chr9_80524074_80524374	0.21	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	86309	0.1
chr14_102290786_102291012	0.21	CTD-2017C7.2		14241	0.14
chr14_64204420_64204571	0.21	ENSG00000252749	.	1333	0.43
chr12_46659525_46659676	0.21	SLC38A1	solute carrier family 38, member 1	1884	0.48
chr5_44713608_44713759	0.21	ENSG00000263556	.	2609	0.4
chr2_202050412_202050706	0.21	CASP10	caspase 10, apoptosis-related cysteine peptidase	2641	0.22
chr22_40858602_40858925	0.20	MKL1	megakaryoblastic leukemia (translocation) 1	659	0.7
chr14_91879481_91879632	0.20	CCDC88C	coiled-coil domain containing 88C	4134	0.28
chr18_53002274_53002527	0.20	TCF4	transcription factor 4	12875	0.28
chr13_48984563_48985023	0.20	LPAR6	lysophosphatidic acid receptor 6	16250	0.26
chr11_67176258_67176520	0.20	TBC1D10C	TBC1 domain family, member 10C	4729	0.07
chr5_156731259_156731410	0.20	CYFIP2	cytoplasmic FMR1 interacting protein 2	6711	0.16
chr21_43516995_43517146	0.20	C21orf128	chromosome 21 open reading frame 128	11574	0.19
chr1_150847141_150847524	0.20	ARNT	aryl hydrocarbon receptor nuclear translocator	1723	0.26
chr7_5518487_5518712	0.20	ENSG00000238394	.	6427	0.13
chr18_8610996_8611147	0.20	RAB12	RAB12, member RAS oncogene family	1628	0.4
chr1_84611671_84611822	0.20	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1792	0.48
chr5_58880144_58880439	0.20	PDE4D	phosphodiesterase 4D, cAMP-specific	1928	0.5
chr8_29948388_29948539	0.19	LEPROTL1	leptin receptor overlapping transcript-like 1	4451	0.17
chr1_89737127_89737489	0.19	GBP5	guanylate binding protein 5	762	0.66
chr18_60824857_60825062	0.19	RP11-299P2.1		6406	0.25
chr22_40858328_40858544	0.19	MKL1	megakaryoblastic leukemia (translocation) 1	986	0.54
chr10_112624321_112624902	0.19	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	6954	0.15
chr6_26442034_26442281	0.19	BTN3A3	butyrophilin, subfamily 3, member A3	1371	0.29
chr3_45706571_45706792	0.19	LIMD1-AS1	LIMD1 antisense RNA 1	23693	0.16
chr1_167891180_167891331	0.19	ADCY10	adenylate cyclase 10 (soluble)	7802	0.18
chr1_211502580_211502753	0.19	TRAF5	TNF receptor-associated factor 5	2487	0.35
chr20_24090206_24090357	0.18	GGTLC1	gamma-glutamyltransferase light chain 1	120865	0.06
chr9_98782803_98783372	0.18	ERCC6L2	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	47968	0.15
chr1_150737104_150737638	0.18	CTSS	cathepsin S	897	0.5
chr6_143249356_143249507	0.18	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	16907	0.25
chr18_13277168_13277319	0.18	LDLRAD4	low density lipoprotein receptor class A domain containing 4	859	0.63
chr15_67374785_67374936	0.18	SMAD3	SMAD family member 3	16060	0.25
chr11_58342434_58343027	0.18	LPXN	leupaxin	604	0.68
chr5_114193091_114193242	0.18	RP11-492A10.1		189059	0.03
chr3_63923691_63923842	0.18	ATXN7	ataxin 7	25491	0.15
chr7_142353602_142353808	0.18	MTRNR2L6	MT-RNR2-like 6	20399	0.23
chr14_99726709_99727240	0.18	AL109767.1		2311	0.33
chr12_66712096_66712247	0.18	HELB	helicase (DNA) B	15846	0.16
chr3_141218856_141219007	0.18	RASA2	RAS p21 protein activator 2	13040	0.21
chr9_3528863_3529151	0.18	RFX3	regulatory factor X, 3 (influences HLA class II expression)	3003	0.37
chr4_129026129_129026280	0.18	LARP1B	La ribonucleoprotein domain family, member 1B	27208	0.24
chr9_117150863_117151014	0.18	AKNA	AT-hook transcription factor	577	0.77
chr5_148726675_148726837	0.18	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	1691	0.25
chr3_176915816_176916502	0.18	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	898	0.7
chr15_90119818_90119983	0.18	TICRR	TOPBP1-interacting checkpoint and replication regulator	1082	0.46
chr6_99380366_99380517	0.18	FBXL4	F-box and leucine-rich repeat protein 4	15361	0.28
chr1_169662937_169663139	0.18	SELL	selectin L	17801	0.18
chr5_35857770_35858187	0.18	IL7R	interleukin 7 receptor	984	0.58
chr15_77287169_77287320	0.18	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	182	0.95
chr1_19717605_19717920	0.17	CAPZB	capping protein (actin filament) muscle Z-line, beta	5471	0.18
chr1_32716475_32716711	0.17	LCK	lymphocyte-specific protein tyrosine kinase	247	0.82
chr2_182329799_182329950	0.17	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	7719	0.31
chr2_237446083_237446280	0.17	IQCA1	IQ motif containing with AAA domain 1	29996	0.19
chr10_126431099_126431666	0.17	FAM53B	family with sequence similarity 53, member B	157	0.95
chr10_63979683_63979834	0.17	RTKN2	rhotekin 2	16264	0.26
chr2_70321937_70322218	0.17	PCBP1-AS1	PCBP1 antisense RNA 1	6099	0.17
chr6_74232761_74232916	0.17	RP11-505P4.7		503	0.51
chr7_148408377_148408528	0.17	CUL1	cullin 1	12448	0.17
chr3_27922887_27923131	0.17	EOMES	eomesodermin	158803	0.04
chr1_239883177_239883989	0.17	CHRM3	cholinergic receptor, muscarinic 3	740	0.59
chr4_109081890_109082041	0.17	LEF1	lymphoid enhancer-binding factor 1	5492	0.25
chr13_36407967_36408118	0.17	DCLK1	doublecortin-like kinase 1	21737	0.28
chr1_89457123_89457381	0.17	CCBL2	cysteine conjugate-beta lyase 2	1035	0.37
chr3_149419430_149419681	0.17	WWTR1	WW domain containing transcription regulator 1	1505	0.39
chr18_56215999_56216150	0.17	RP11-126O1.2		8228	0.17
chr2_55236798_55237891	0.17	RTN4	reticulon 4	241	0.93
chr3_66514964_66515132	0.17	LRIG1	leucine-rich repeats and immunoglobulin-like domains 1	36308	0.22
chr19_42432968_42433149	0.17	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	5812	0.14
chr12_68044712_68044863	0.17	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	462	0.87
chr3_59996849_59997073	0.17	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	39378	0.24
chr5_110560941_110561277	0.17	CAMK4	calcium/calmodulin-dependent protein kinase IV	1325	0.51
chr19_1465997_1466148	0.17	ENSG00000267317	.	3308	0.09
chr3_18475636_18475787	0.17	SATB1	SATB homeobox 1	1034	0.57
chr1_230307234_230307385	0.17	RP5-956O18.2		96920	0.07
chr6_75924948_75925099	0.17	COL12A1	collagen, type XII, alpha 1	9256	0.22
chr6_143264256_143264520	0.17	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	1950	0.43
chr2_106372259_106372410	0.17	NCK2	NCK adaptor protein 2	10146	0.29
chr9_4664226_4664377	0.17	PPAPDC2	phosphatidic acid phosphatase type 2 domain containing 2	2003	0.26
chr11_62367040_62367191	0.17	MTA2	metastasis associated 1 family, member 2	326	0.7
chr2_38825620_38825771	0.17	HNRNPLL	heterogeneous nuclear ribonucleoprotein L-like	1473	0.39
chr12_133083232_133083480	0.16	FBRSL1	fibrosin-like 1	16199	0.2
chr5_75842727_75842878	0.16	IQGAP2	IQ motif containing GTPase activating protein 2	432	0.88
chr1_198873027_198873178	0.16	ENSG00000207759	.	44820	0.17
chr11_117685491_117685642	0.16	DSCAML1	Down syndrome cell adhesion molecule like 1	2674	0.19
chr1_158903283_158903483	0.16	PYHIN1	pyrin and HIN domain family, member 1	2025	0.36
chr12_10019991_10020525	0.16	RP11-290C10.1		632	0.61
chr3_141745583_141745864	0.16	TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	1716	0.46
chr7_7960072_7960471	0.16	ENSG00000201747	.	14121	0.18
chr1_156722427_156722776	0.16	HDGF	hepatoma-derived growth factor	361	0.75
chr3_151989454_151989605	0.16	MBNL1-AS1	MBNL1 antisense RNA 1	2185	0.3
chr15_33493746_33494182	0.16	FMN1	formin 1	7067	0.29
chr11_62358316_62359010	0.16	TUT1	terminal uridylyl transferase 1, U6 snRNA-specific	332	0.71
chr5_95170159_95170387	0.16	GLRX	glutaredoxin (thioltransferase)	11564	0.14
chr19_16195500_16195773	0.16	TPM4	tropomyosin 4	3103	0.21
chr1_204490030_204490190	0.16	MDM4	Mdm4 p53 binding protein homolog (mouse)	4491	0.2
chr21_16816003_16816154	0.16	ENSG00000212564	.	170524	0.04
chr1_244487830_244488005	0.16	C1orf100	chromosome 1 open reading frame 100	28020	0.22
chr9_102972411_102972625	0.16	ENSG00000239908	.	107677	0.06
chr5_74965499_74965780	0.16	ENSG00000207333	.	39785	0.14
chr11_11865444_11865596	0.16	USP47	ubiquitin specific peptidase 47	1907	0.47
chr7_106505707_106506635	0.16	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	247	0.95
chr4_56773645_56773796	0.16	ENSG00000202358	.	21959	0.16
chr22_40914778_40915024	0.16	RP4-591N18.2		2903	0.23
chrX_153023566_153023717	0.16	PLXNB3	plexin B3	6010	0.1
chr21_37670145_37670473	0.16	MORC3	MORC family CW-type zinc finger 3	22178	0.13
chr5_118623311_118623849	0.16	ENSG00000243333	.	18746	0.17
chr3_71503791_71503942	0.16	ENSG00000221264	.	87374	0.09
chr12_121829638_121829987	0.16	ANAPC5	anaphase promoting complex subunit 5	7887	0.2
chr22_50631230_50631436	0.16	TRABD	TraB domain containing	110	0.82
chr5_79251776_79251927	0.16	RP11-168A11.1		19449	0.2
chr1_108328348_108328499	0.16	ENSG00000265536	.	9545	0.26
chr2_197030897_197031094	0.16	STK17B	serine/threonine kinase 17b	4729	0.22
chr11_11865222_11865373	0.16	USP47	ubiquitin specific peptidase 47	1684	0.51
chr12_55372250_55372401	0.16	TESPA1	thymocyte expressed, positive selection associated 1	3297	0.29
chr1_225968168_225968319	0.15	SRP9	signal recognition particle 9kDa	2606	0.22
chr6_26304754_26304905	0.15	HIST1H4H	histone cluster 1, H4h	19067	0.08
chr20_10481692_10481843	0.15	SLX4IP	SLX4 interacting protein	65816	0.11
chr14_25134813_25134997	0.15	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	31432	0.15
chr4_146098361_146098512	0.15	OTUD4	OTU domain containing 4	871	0.65
chr4_153022445_153022684	0.15	ENSG00000266244	.	127056	0.05
chr1_26644827_26645344	0.15	UBXN11	UBX domain protein 11	231	0.76
chr14_91869059_91869463	0.15	CCDC88C	coiled-coil domain containing 88C	14429	0.23
chr18_56355169_56355320	0.15	RP11-126O1.4		10398	0.15
chr2_200490274_200490425	0.15	SATB2	SATB homeobox 2	154360	0.04
chr5_130881277_130881428	0.15	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	12626	0.29
chr4_178237433_178237648	0.15	NEIL3	nei endonuclease VIII-like 3 (E. coli)	6550	0.23
chr4_146541198_146541349	0.15	MMAA	methylmalonic aciduria (cobalamin deficiency) cblA type	1858	0.37
chr12_118795905_118796056	0.15	TAOK3	TAO kinase 3	930	0.65
chr6_12065087_12065238	0.15	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	49342	0.17
chr4_113444412_113444838	0.15	NEUROG2	neurogenin 2	7297	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.2	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.1	0.4	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.4	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.2	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0001878	response to yeast(GO:0001878)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0052257	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.3	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0031063	regulation of histone deacetylation(GO:0031063) positive regulation of histone deacetylation(GO:0031065)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0070601	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.4	GO:0019433	triglyceride catabolic process(GO:0019433)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0045901	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0035844	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.0	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.3	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0009713	catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.2	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0018202	peptidyl-histidine modification(GO:0018202)
0.0	0.1	GO:0045842	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.0	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.2	GO:0043489	RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.0	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.0	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.3	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0051322	anaphase(GO:0051322)
0.0	0.0	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0035269	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.0	GO:0070233	negative regulation of T cell apoptotic process(GO:0070233)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0050860	regulation of T cell receptor signaling pathway(GO:0050856) negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.2	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0010390	histone monoubiquitination(GO:0010390)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.0	GO:0035751	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:0042403	thyroid hormone metabolic process(GO:0042403)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	GO:0000800	lateral element(GO:0000800)
0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0042382	paraspeckles(GO:0042382)
0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	GO:0031932	TORC2 complex(GO:0031932)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.2	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	GO:0000125	PCAF complex(GO:0000125)
0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2	GO:0000242	pericentriolar material(GO:0000242)
0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	GO:0005827	polar microtubule(GO:0005827)
0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.3	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	GO:0042827	platelet dense granule(GO:0042827)
0.0	GO:0031501	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.6	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.4	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.0	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.0	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.0	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.2	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.0	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.0	GO:0035004	phosphatidylinositol 3-kinase activity(GO:0035004)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.0	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.6	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.6	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.1	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.3	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.3	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family