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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for ONECUT2_ONECUT3

Z-value: 1.42

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Transcription factors associated with ONECUT2_ONECUT3

Gene Symbol	Gene ID	Gene Info
ONECUT2 Ensembl NCBI GeneCards UniProt	ENSG00000119547.5	one cut homeobox 2
ONECUT3 Ensembl NCBI GeneCards UniProt	ENSG00000205922.4	one cut homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr18_55101682_55102405	ONECUT2	874	0.450005	-0.65	5.8e-02	Click!
chr18_55108207_55108358	ONECUT2	3326	0.257933	-0.56	1.2e-01	Click!
chr18_55097019_55097310	ONECUT2	5753	0.218301	-0.45	2.2e-01	Click!
chr18_55108476_55109011	ONECUT2	2865	0.278155	-0.33	3.8e-01	Click!
chr18_55101119_55101270	ONECUT2	1723	0.325356	-0.28	4.6e-01	Click!
chr19_1748094_1748245	ONECUT3	4203	0.160848	-0.60	8.9e-02	Click!
chr19_1725454_1725639	ONECUT3	26826	0.113872	-0.59	9.7e-02	Click!
chr19_1748614_1748765	ONECUT3	3683	0.168872	-0.36	3.4e-01	Click!
chr19_1749427_1749644	ONECUT3	2837	0.191666	-0.35	3.6e-01	Click!
chr19_1773658_1773809	ONECUT3	21361	0.099840	-0.35	3.6e-01	Click!

Activity of the ONECUT2_ONECUT3 motif across conditions

Conditions sorted by the z-value of the ONECUT2_ONECUT3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_32976430_32976581	1.21	ENSG00000263780	.	15342	0.19
chr17_61727557_61727708	0.83	MAP3K3	mitogen-activated protein kinase kinase kinase 3	27562	0.12
chr1_181474291_181474442	0.83	CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	21485	0.28
chr8_121761660_121761834	0.82	RP11-713M15.1		11746	0.25
chr12_25207113_25207806	0.80	LRMP	lymphoid-restricted membrane protein	1785	0.37
chr7_130610833_130610984	0.79	ENSG00000226380	.	48610	0.15
chr7_50348888_50349341	0.78	IKZF1	IKAROS family zinc finger 1 (Ikaros)	796	0.76
chr14_89831123_89831421	0.78	RP11-356K23.2		9868	0.17
chr11_3852411_3852562	0.77	RHOG	ras homolog family member G	605	0.57
chrX_117632028_117632179	0.77	DOCK11	dedicator of cytokinesis 11	2231	0.39
chr10_50398086_50398237	0.77	C10orf128	chromosome 10 open reading frame 128	1725	0.38
chr6_24951057_24951285	0.74	FAM65B	family with sequence similarity 65, member B	14983	0.22
chr14_24020377_24021144	0.68	ZFHX2	zinc finger homeobox 2	98	0.94
chr6_25405502_25405752	0.68	ENSG00000253017	.	2496	0.27
chr8_18054305_18054456	0.67	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	13222	0.27
chr17_441739_441890	0.67	RP5-1029F21.2		13992	0.17
chr13_48736574_48736800	0.66	MED4	mediator complex subunit 4	67420	0.1
chr1_114476630_114476781	0.63	HIPK1	homeodomain interacting protein kinase 1	3355	0.17
chr2_202127394_202127951	0.63	CASP8	caspase 8, apoptosis-related cysteine peptidase	993	0.56
chr13_30510013_30510639	0.62	LINC00572	long intergenic non-protein coding RNA 572	9538	0.3
chr1_66799510_66799957	0.62	PDE4B	phosphodiesterase 4B, cAMP-specific	1861	0.5
chr1_206729975_206731239	0.62	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	114	0.96
chr7_7298190_7298341	0.61	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	24314	0.22
chr2_55455458_55455609	0.60	RPS27A	ribosomal protein S27a	3506	0.17
chr18_29601411_29601562	0.60	RNF125	ring finger protein 125, E3 ubiquitin protein ligase	3151	0.21
chr13_50638056_50638207	0.60	ENSG00000231607	.	14794	0.14
chr1_40849833_40850457	0.60	SMAP2	small ArfGAP2	9825	0.18
chr2_40621643_40621794	0.60	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	35702	0.23
chrX_70272475_70272626	0.60	SNX12	sorting nexin 12	15703	0.12
chr11_104914640_104914826	0.59	CARD16	caspase recruitment domain family, member 16	1301	0.41
chr11_85754438_85754589	0.59	PICALM	phosphatidylinositol binding clathrin assembly protein	25309	0.2
chr10_60038316_60038467	0.58	CISD1	CDGSH iron sulfur domain 1	9573	0.19
chr9_4762764_4763000	0.58	AK3	adenylate kinase 3	20839	0.16
chr21_15917916_15918619	0.58	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr2_197126307_197126458	0.57	AC020571.3		1225	0.49
chr10_63660554_63661323	0.53	ARID5B	AT rich interactive domain 5B (MRF1-like)	121	0.98
chr9_132801987_132802138	0.52	FNBP1	formin binding protein 1	3379	0.25
chr2_158299517_158299677	0.52	CYTIP	cytohesin 1 interacting protein	1057	0.48
chr12_93638285_93638436	0.51	ENSG00000238361	.	21148	0.16
chrX_76924403_76924554	0.51	ATRX	alpha thalassemia/mental retardation syndrome X-linked	48242	0.18
chr2_143908498_143908649	0.51	RP11-190J23.1		21168	0.22
chr16_79197756_79198135	0.50	RP11-556H2.2		58091	0.12
chr15_99443302_99443551	0.50	RP11-654A16.1		6662	0.22
chr15_63777077_63777228	0.50	USP3	ubiquitin specific peptidase 3	19641	0.22
chr2_143910568_143910719	0.50	RP11-190J23.1		19098	0.23
chr4_36244695_36244948	0.50	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	740	0.5
chr2_46688788_46688939	0.49	ENSG00000241791	.	13213	0.16
chr6_24928259_24928410	0.49	FAM65B	family with sequence similarity 65, member B	7854	0.24
chr10_120965669_120965820	0.49	GRK5	G protein-coupled receptor kinase 5	1357	0.32
chr18_10868392_10868543	0.49	PIEZO2	piezo-type mechanosensitive ion channel component 2	13033	0.24
chr13_97879341_97880219	0.49	MBNL2	muscleblind-like splicing regulator 2	5171	0.33
chr12_122589685_122589889	0.48	MLXIP	MLX interacting protein	22640	0.18
chr3_56627689_56627840	0.48	CCDC66	coiled-coil domain containing 66	34984	0.2
chr17_33868045_33868636	0.47	SLFN12L	schlafen family member 12-like	3460	0.14
chr5_108956915_108957066	0.47	ENSG00000266090	.	64291	0.12
chr16_71915132_71915582	0.45	RP11-498D10.3		819	0.43
chr20_52269637_52270024	0.45	ENSG00000238468	.	15467	0.22
chr14_53208430_53208600	0.44	STYX	serine/threonine/tyrosine interacting protein	11615	0.15
chr9_273424_273720	0.44	DOCK8	dedicator of cytokinesis 8	502	0.5
chr3_152027985_152028136	0.44	MBNL1	muscleblind-like splicing regulator 1	10073	0.22
chr4_87050749_87050921	0.44	RP11-778J15.1		9968	0.23
chr10_105670292_105670878	0.44	OBFC1	oligonucleotide/oligosaccharide-binding fold containing 1	6842	0.18
chr12_32114494_32114645	0.44	KIAA1551	KIAA1551	854	0.68
chr6_130534438_130534589	0.43	SAMD3	sterile alpha motif domain containing 3	1922	0.46
chr9_80524074_80524374	0.43	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	86309	0.1
chr5_57787350_57787738	0.43	GAPT	GRB2-binding adaptor protein, transmembrane	280	0.92
chr11_108443146_108443297	0.43	EXPH5	exophilin 5	4368	0.28
chr5_98276840_98277133	0.43	ENSG00000200351	.	4535	0.25
chr18_46572008_46572159	0.43	ENSG00000263849	.	4055	0.23
chr10_7451836_7452578	0.43	SFMBT2	Scm-like with four mbt domains 2	904	0.71
chr4_82415207_82415715	0.42	RASGEF1B	RasGEF domain family, member 1B	22392	0.28
chr8_21817827_21818019	0.42	XPO7	exportin 7	5826	0.19
chr3_71632242_71632973	0.42	FOXP1	forkhead box P1	297	0.91
chrX_30594869_30596024	0.42	CXorf21	chromosome X open reading frame 21	515	0.84
chr14_52328565_52328716	0.42	GNG2	guanine nucleotide binding protein (G protein), gamma 2	598	0.77
chr2_69002223_69002932	0.42	ARHGAP25	Rho GTPase activating protein 25	505	0.84
chr17_80084198_80084349	0.41	CCDC57	coiled-coil domain containing 57	2159	0.16
chr1_198581577_198581728	0.41	PTPRC	protein tyrosine phosphatase, receptor type, C	26149	0.21
chr8_82052502_82052653	0.41	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	28274	0.23
chr10_76728189_76728340	0.41	RP11-77G23.5		55745	0.12
chr6_128239129_128239316	0.41	THEMIS	thymocyte selection associated	463	0.89
chr2_46005650_46005801	0.41	U51244.2		103110	0.07
chr14_61793878_61794206	0.41	PRKCH	protein kinase C, eta	411	0.85
chr1_32394372_32394767	0.40	PTP4A2	protein tyrosine phosphatase type IVA, member 2	8817	0.18
chr15_56760953_56761104	0.40	MNS1	meiosis-specific nuclear structural 1	3693	0.33
chr1_175178431_175178668	0.40	KIAA0040	KIAA0040	16470	0.25
chr12_93529897_93530048	0.40	RP11-511B23.2		2895	0.3
chr5_109024574_109025025	0.39	MAN2A1	mannosidase, alpha, class 2A, member 1	268	0.92
chr1_101471229_101471380	0.39	RP11-421L21.2		10275	0.14
chr5_177665530_177665681	0.39	PHYKPL	5-phosphohydroxy-L-lysine phospho-lyase	5819	0.22
chr6_15337079_15337415	0.39	ENSG00000201519	.	12544	0.21
chr13_99857558_99857709	0.39	ENSG00000201793	.	329	0.88
chr20_32312104_32312255	0.39	PXMP4	peroxisomal membrane protein 4, 24kDa	4054	0.13
chr8_120448366_120448517	0.39	NOV	nephroblastoma overexpressed	19895	0.19
chr1_144084788_144084939	0.38	NBPF8	neuroblastoma breakpoint family, member 8	61945	0.14
chr12_49626686_49627168	0.38	TUBA1C	tubulin, alpha 1c	5218	0.14
chr5_149791368_149791565	0.38	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	829	0.6
chr2_28978187_28978588	0.38	PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	3668	0.21
chr16_64412662_64412813	0.38	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	680844	0.0
chr7_77177930_77178081	0.38	PTPN12	protein tyrosine phosphatase, non-receptor type 12	2936	0.37
chrX_109250264_109250544	0.38	TMEM164	transmembrane protein 164	4061	0.29
chr15_41701772_41702069	0.38	NDUFAF1	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	7203	0.15
chrX_38665528_38665784	0.38	MID1IP1-AS1	MID1IP1 antisense RNA 1	2520	0.31
chr15_91955696_91955847	0.37	SV2B	synaptic vesicle glycoprotein 2B	186671	0.03
chr19_2083107_2083981	0.37	MOB3A	MOB kinase activator 3A	1847	0.21
chr5_39203281_39203432	0.37	FYB	FYN binding protein	227	0.96
chr7_38209053_38209204	0.37	STARD3NL	STARD3 N-terminal like	8696	0.31
chr1_151634486_151634721	0.36	SNX27	sorting nexin family member 27	23271	0.08
chr2_185461919_185462338	0.36	ZNF804A	zinc finger protein 804A	965	0.73
chr12_68844621_68844772	0.36	MDM1	Mdm1 nuclear protein homolog (mouse)	118535	0.06
chr7_150382525_150383418	0.36	GIMAP2	GTPase, IMAP family member 2	156	0.95
chr12_54891959_54892179	0.36	NCKAP1L	NCK-associated protein 1-like	499	0.73
chr2_233948481_233948771	0.36	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	23437	0.17
chr1_207496793_207497173	0.35	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	1847	0.46
chr2_197026499_197026722	0.35	STK17B	serine/threonine kinase 17b	5239	0.22
chr7_36192851_36193841	0.35	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	469	0.85
chr5_26147309_26147460	0.35	ENSG00000222560	.	134386	0.06
chr9_34957561_34957764	0.35	KIAA1045	KIAA1045	178	0.94
chr1_208047081_208047232	0.35	CD34	CD34 molecule	16681	0.25
chr3_108322928_108323079	0.34	DZIP3	DAZ interacting zinc finger protein 3	1305	0.45
chr11_85758745_85758896	0.34	PICALM	phosphatidylinositol binding clathrin assembly protein	21002	0.21
chr14_90108423_90108574	0.34	ENSG00000252655	.	8749	0.14
chr10_22901004_22901155	0.34	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	20437	0.27
chr12_4283030_4283181	0.34	CCND2	cyclin D2	99833	0.07
chr8_61823770_61824122	0.34	RP11-33I11.2		101781	0.08
chr10_73974639_73974790	0.34	ASCC1	activating signal cointegrator 1 complex subunit 1	980	0.36
chr1_183558852_183559003	0.33	NCF2	neutrophil cytosolic factor 2	789	0.65
chr8_15861662_15861813	0.33	MSR1	macrophage scavenger receptor 1	160023	0.04
chr1_2082433_2082584	0.33	RP5-892K4.1		5790	0.14
chr7_79953796_79953947	0.33	ENSG00000240347	.	6302	0.23
chr7_72696264_72696415	0.33	GTF2IRD2P1	GTF2I repeat domain containing 2 pseudogene 1	2196	0.24
chr5_148188094_148188245	0.33	ADRB2	adrenoceptor beta 2, surface	17987	0.25
chr4_103783164_103783315	0.33	ENSG00000238948	.	2586	0.2
chr2_20091613_20091764	0.33	TTC32	tetratricopeptide repeat domain 32	9714	0.25
chr14_89882597_89883166	0.33	FOXN3	forkhead box N3	575	0.54
chr13_107025572_107025723	0.33	EFNB2	ephrin-B2	161815	0.04
chr2_44403792_44403943	0.33	PPM1B	protein phosphatase, Mg2+/Mn2+ dependent, 1B	7818	0.18
chr17_5484149_5484300	0.33	NLRP1	NLR family, pyrin domain containing 1	3053	0.28
chr16_89538828_89538979	0.33	ANKRD11	ankyrin repeat domain 11	17823	0.11
chr13_49079711_49079862	0.32	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	27427	0.22
chr19_52268680_52268969	0.32	FPR2	formyl peptide receptor 2	2807	0.17
chr1_89594453_89594640	0.32	GBP2	guanylate binding protein 2, interferon-inducible	2749	0.27
chr2_185465044_185465320	0.32	ZNF804A	zinc finger protein 804A	2089	0.5
chr3_18482753_18482904	0.32	SATB1	SATB homeobox 1	2563	0.29
chr11_46136336_46136487	0.32	ENSG00000263539	.	1642	0.4
chr5_93917742_93917893	0.32	ENSG00000211498	.	3343	0.25
chr1_66798585_66798917	0.31	PDE4B	phosphodiesterase 4B, cAMP-specific	879	0.74
chr7_26141262_26141558	0.31	ENSG00000266430	.	41451	0.15
chr4_71570546_71572213	0.31	RUFY3	RUN and FYVE domain containing 3	861	0.36
chr1_207262735_207262932	0.31	C4BPB	complement component 4 binding protein, beta	54	0.97
chr1_247574766_247574917	0.31	NLRP3	NLR family, pyrin domain containing 3	4617	0.2
chr5_118355478_118355629	0.31	ENSG00000223179	.	12287	0.16
chr4_184642687_184643147	0.31	ENSG00000251739	.	15833	0.17
chr3_18478655_18478806	0.31	SATB1	SATB homeobox 1	1454	0.45
chr2_266277_266428	0.31	ACP1	acid phosphatase 1, soluble	1426	0.31
chrX_78401406_78401924	0.31	GPR174	G protein-coupled receptor 174	24804	0.27
chr17_30816627_30816809	0.31	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	1904	0.22
chr12_4384723_4384874	0.31	CCND2	cyclin D2	432	0.41
chr6_169612787_169612938	0.30	XXyac-YX65C7_A.2		487	0.87
chr3_151921407_151921835	0.30	MBNL1	muscleblind-like splicing regulator 1	64208	0.12
chr11_72647389_72647540	0.30	FCHSD2	FCH and double SH3 domains 2	52593	0.12
chr14_34413988_34414139	0.30	EGLN3	egl-9 family hypoxia-inducible factor 3	5969	0.27
chr7_50354880_50355316	0.30	IKZF1	IKAROS family zinc finger 1 (Ikaros)	6780	0.3
chr10_17705012_17705163	0.30	ENSG00000251959	.	16100	0.14
chr1_117529081_117529232	0.30	CD101	CD101 molecule	15226	0.16
chr15_55582423_55582730	0.29	RAB27A	RAB27A, member RAS oncogene family	575	0.75
chr7_26331698_26332123	0.29	SNX10	sorting nexin 10	225	0.95
chr12_122124689_122124840	0.29	MORN3	MORN repeat containing 3	17204	0.17
chrX_78619893_78620072	0.29	ITM2A	integral membrane protein 2A	2874	0.42
chr8_133787215_133787383	0.29	PHF20L1	PHD finger protein 20-like 1	322	0.89
chr9_123886056_123886207	0.29	CNTRL	centriolin	2052	0.35
chrX_15934152_15934303	0.29	ENSG00000200566	.	199	0.96
chr1_198613830_198613981	0.28	PTPRC	protein tyrosine phosphatase, receptor type, C	5613	0.26
chr13_46952408_46952559	0.28	KIAA0226L	KIAA0226-like	297	0.9
chr20_62588051_62588276	0.28	UCKL1	uridine-cytidine kinase 1-like 1	394	0.66
chr3_134206036_134206187	0.28	ANAPC13	anaphase promoting complex subunit 13	553	0.63
chr4_55575983_55576134	0.28	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	51973	0.18
chr8_108509086_108509237	0.28	ANGPT1	angiopoietin 1	1077	0.7
chr2_114659464_114659615	0.28	ACTR3	ARP3 actin-related protein 3 homolog (yeast)	11364	0.23
chr4_85886471_85886934	0.28	WDFY3	WD repeat and FYVE domain containing 3	801	0.75
chr7_96357973_96358124	0.28	SHFM1	split hand/foot malformation (ectrodactyly) type 1	18845	0.27
chr6_6386490_6386781	0.28	F13A1	coagulation factor XIII, A1 polypeptide	65389	0.13
chr3_30699890_30700041	0.28	RP11-1024P17.1		39188	0.19
chrX_129130468_129130619	0.28	BCORL1	BCL6 corepressor-like 1	8621	0.22
chr4_74046909_74047092	0.27	ANKRD17	ankyrin repeat domain 17	41831	0.16
chr14_61870519_61870670	0.27	PRKCH	protein kinase C, eta	13182	0.24
chr5_88076518_88076805	0.27	MEF2C	myocyte enhancer factor 2C	42944	0.17
chr8_117642188_117642339	0.27	EIF3H	eukaryotic translation initiation factor 3, subunit H	125760	0.05
chr3_3214293_3214763	0.27	CRBN	cereblon	6830	0.19
chr12_50908341_50908492	0.27	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	9526	0.23
chr17_57969956_57970188	0.27	TUBD1	tubulin, delta 1	4	0.87
chr6_147525530_147526351	0.27	STXBP5-AS1	STXBP5 antisense RNA 1	190	0.61
chr18_18654105_18654256	0.27	ENSG00000216205	.	11746	0.22
chr5_49968694_49968985	0.27	PARP8	poly (ADP-ribose) polymerase family, member 8	5448	0.35
chr16_2771529_2771859	0.27	PRSS27	protease, serine 27	1478	0.22
chr21_15917471_15917848	0.27	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	1003	0.63
chrX_70585572_70585765	0.27	TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	446	0.84
chr17_74547322_74547606	0.27	RP11-666A8.12		30	0.69
chr12_40588874_40589025	0.26	LRRK2	leucine-rich repeat kinase 2	1597	0.46
chr15_77711149_77711991	0.26	PEAK1	pseudopodium-enriched atypical kinase 1	872	0.51

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.3	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.3	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.3	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.5	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.3	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	0.2	GO:0070669	response to interleukin-2(GO:0070669)
0.1	0.3	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.1	0.2	GO:0032060	bleb assembly(GO:0032060)
0.1	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.2	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.1	0.4	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.4	GO:0015671	oxygen transport(GO:0015671)
0.1	0.2	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.1	0.2	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.1	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.3	GO:0070897	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0	0.4	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.4	GO:1903078	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.2	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0002902	regulation of B cell apoptotic process(GO:0002902)
0.0	0.2	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.3	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0015911	plasma membrane long-chain fatty acid transport(GO:0015911)
0.0	0.5	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.1	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.2	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.1	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0072577	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.3	GO:0050718	positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0	0.7	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.2	GO:0033005	positive regulation of mast cell activation(GO:0033005)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:1902745	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.4	GO:0007032	endosome organization(GO:0007032)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.2	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.2	GO:0040001	establishment of mitotic spindle localization(GO:0040001)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0016233	telomere capping(GO:0016233)
0.0	0.3	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.5	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	0.1	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0060872	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.2	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.0	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0071027	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.4	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0	0.0	GO:0000154	rRNA modification(GO:0000154)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.4	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0061726	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.3	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.2	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.0	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.2	GO:0043486	histone exchange(GO:0043486)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.5	GO:0034976	response to endoplasmic reticulum stress(GO:0034976)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.1	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.6	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.2	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.3	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.4	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.6	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.2	GO:0043073	germ cell nucleus(GO:0043073)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.3	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.3	GO:0030667	secretory granule membrane(GO:0030667)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	0.2	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1	0.2	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.1	0.2	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.2	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.7	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.4	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.8	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.3	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.3	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.2	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.3	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.5	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.3	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.8	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.3	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	0.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.8	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.3	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.0	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.0	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0001848	complement binding(GO:0001848)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.7	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.1	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.7	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.4	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.3	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.1	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.4	PID IL4 2PATHWAY	IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1	0.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.3	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.5	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.4	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.0	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.2	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.1	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	0.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.2	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.0	REACTOME SIGNALING BY ILS	Genes involved in Signaling by Interleukins
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.5	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.4	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants

Results for ONECUT2_ONECUT3

Z-value: 1.42

Motif logo

Transcription factors associated with ONECUT2_ONECUT3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ONECUT2_ONECUT3 motif across conditions

Conditions sorted by the z-value of the ONECUT2_ONECUT3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: