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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.44

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt	ENSG00000171540.6	orthopedia homeobox
PHOX2B Ensembl NCBI GeneCards UniProt	ENSG00000109132.5	paired like homeobox 2B
LHX1 Ensembl NCBI GeneCards UniProt	ENSG00000132130.7	LIM homeobox 1
LMX1A Ensembl NCBI GeneCards UniProt	ENSG00000162761.10	LIM homeobox transcription factor 1 alpha
LHX5 Ensembl NCBI GeneCards UniProt	ENSG00000089116.3	LIM homeobox 5
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000198353.6	homeobox C4
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000273266.1	homeobox C4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr12_54412522_54412673	HOXC4	1882	0.125436	-0.68	4.6e-02	Click!
chr12_54448288_54448439	HOXC4	702	0.456392	-0.63	6.9e-02	Click!
chr12_54413113_54413275	HOXC4	2479	0.100103	-0.59	9.1e-02	Click!
chr12_54414463_54414622	HOXC4	3827	0.078840	-0.57	1.1e-01	Click!
chr12_54414044_54414195	HOXC4	3404	0.082972	-0.54	1.3e-01	Click!
chr17_35296589_35296740	LHX1	2580	0.174020	-0.57	1.1e-01	Click!
chr17_35294233_35294680	LHX1	372	0.548623	-0.46	2.1e-01	Click!
chr17_35296098_35296249	LHX1	2089	0.198791	-0.24	5.3e-01	Click!
chr17_35294704_35295327	LHX1	931	0.353475	-0.10	8.0e-01	Click!
chr12_113917552_113917703	LHX5	7750	0.177261	-0.60	8.5e-02	Click!
chr1_165345218_165345646	LMX1A	19480	0.226195	-0.68	4.3e-02	Click!
chr1_165325493_165325712	LMX1A	124	0.976257	-0.66	5.1e-02	Click!
chr1_165325208_165325359	LMX1A	195	0.962784	-0.66	5.4e-02	Click!
chr1_165367450_165367601	LMX1A	41573	0.154391	-0.50	1.7e-01	Click!
chr1_165334294_165334445	LMX1A	8417	0.260620	-0.44	2.4e-01	Click!
chr5_76940792_76940948	OTP	5357	0.256081	0.57	1.1e-01	Click!
chr5_76926907_76927215	OTP	8452	0.231374	-0.53	1.4e-01	Click!
chr5_76939751_76939902	OTP	4313	0.270060	0.41	2.7e-01	Click!
chr5_76941226_76941412	OTP	5806	0.252064	-0.37	3.2e-01	Click!
chr5_76927221_76927372	OTP	8217	0.232386	-0.35	3.5e-01	Click!

Activity of the OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif across conditions

Conditions sorted by the z-value of the OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_31309966_31310295	3.29	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chr10_30745504_30745655	2.53	MAP3K8	mitogen-activated protein kinase kinase kinase 8	17828	0.21
chr1_114413652_114413958	2.21	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	515	0.69
chr6_159071306_159071615	2.14	SYTL3	synaptotagmin-like 3	414	0.83
chr7_106507057_106507208	2.04	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr6_26198173_26198564	1.89	HIST1H3D	histone cluster 1, H3d	890	0.22
chr14_22968352_22968523	1.82	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	12266	0.1
chr6_159464766_159465080	1.74	TAGAP	T-cell activation RhoGTPase activating protein	1127	0.51
chr17_78755045_78755196	1.73	RP11-28G8.1		24312	0.21
chr9_128586563_128586792	1.70	PBX3	pre-B-cell leukemia homeobox 3	40873	0.21
chr13_33608099_33608250	1.70	ENSG00000221677	.	7315	0.24
chr4_2486639_2486842	1.68	RNF4	ring finger protein 4	4798	0.2
chr1_169679248_169679951	1.66	SELL	selectin L	1240	0.48
chr1_113164228_113164419	1.65	ST7L	suppression of tumorigenicity 7 like	2283	0.19
chr13_41555714_41555943	1.62	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr14_100535454_100535614	1.57	EVL	Enah/Vasp-like	2760	0.21
chr1_226251298_226251924	1.53	H3F3A	H3 histone, family 3A	67	0.97
chr14_25143618_25143855	1.47	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	40263	0.14
chr3_95425254_95425405	1.46	ENSG00000221477	.	460417	0.01
chr7_26141262_26141558	1.45	ENSG00000266430	.	41451	0.15
chr5_118653769_118653920	1.45	ENSG00000243333	.	11518	0.19
chr3_56949638_56949992	1.45	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	684	0.75
chr14_22947593_22947744	1.42	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr19_16438052_16438433	1.40	KLF2	Kruppel-like factor 2	2591	0.21
chr13_99910339_99910626	1.40	GPR18	G protein-coupled receptor 18	146	0.96
chr2_143887292_143887566	1.38	ARHGAP15	Rho GTPase activating protein 15	546	0.84
chrX_19815653_19816006	1.37	SH3KBP1	SH3-domain kinase binding protein 1	2040	0.46
chr2_38894094_38894271	1.37	GALM	galactose mutarotase (aldose 1-epimerase)	923	0.55
chr12_10019991_10020525	1.34	RP11-290C10.1		632	0.61
chr3_20050398_20050549	1.34	PP2D1	protein phosphatase 2C-like domain containing 1	3349	0.22
chr21_35306376_35306527	1.33	LINC00649	long intergenic non-protein coding RNA 649	2933	0.21
chr5_57787350_57787738	1.30	GAPT	GRB2-binding adaptor protein, transmembrane	280	0.92
chr1_112013416_112013602	1.28	C1orf162	chromosome 1 open reading frame 162	2905	0.14
chr1_151253624_151253775	1.27	ZNF687	zinc finger protein 687	395	0.58
chr5_98362961_98363596	1.24	ENSG00000200351	.	90827	0.09
chr13_49065751_49065929	1.21	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	41373	0.17
chr5_131762557_131762944	1.21	AC116366.5		344	0.83
chr1_227501319_227501470	1.18	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	3489	0.36
chr1_198627689_198627922	1.17	RP11-553K8.5		8385	0.25
chr8_22961002_22961301	1.17	TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	717	0.58
chr2_143916963_143917114	1.16	RP11-190J23.1		12703	0.25
chr9_20242645_20242902	1.15	ENSG00000221744	.	52229	0.16
chr6_114178016_114178613	1.15	MARCKS	myristoylated alanine-rich protein kinase C substrate	227	0.93
chr5_44684027_44684178	1.14	ENSG00000263556	.	32190	0.23
chr17_28085648_28085799	1.13	RP11-82O19.1		2398	0.25
chr12_9912992_9913534	1.13	CD69	CD69 molecule	234	0.92
chrX_31453419_31453570	1.12	ENSG00000252903	.	87185	0.1
chr1_184121923_184122452	1.10	ENSG00000199840	.	18770	0.25
chrX_54948821_54948972	1.09	TRO	trophinin	486	0.79
chr5_81074467_81075538	1.08	SSBP2	single-stranded DNA binding protein 2	27930	0.25
chr17_75456326_75456913	1.08	SEPT9	septin 9	4171	0.18
chrX_73164212_73165045	1.06	RP13-216E22.5		24692	0.23
chrX_119619280_119620483	1.05	LAMP2	lysosomal-associated membrane protein 2	16661	0.2
chr1_226891507_226891879	1.04	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	28925	0.16
chr21_36772703_36772854	1.02	ENSG00000211590	.	320235	0.01
chrX_20996388_20996539	1.01	ENSG00000206716	.	236292	0.02
chr6_30797258_30797409	1.01	ENSG00000202241	.	34694	0.07
chr15_64679591_64679870	1.00	TRIP4	thyroid hormone receptor interactor 4	273	0.85
chr11_88087417_88087693	0.99	CTSC	cathepsin C	16600	0.28
chr3_151963607_151963763	0.98	MBNL1	muscleblind-like splicing regulator 1	22144	0.21
chr14_91881184_91881623	0.98	CCDC88C	coiled-coil domain containing 88C	2287	0.37
chr17_78705219_78705370	0.98	RP11-28G8.1		74138	0.1
chrX_53356672_53356823	0.97	ENSG00000207408	.	2980	0.23
chrY_15815919_15816489	0.97	TMSB4Y	thymosin beta 4, Y-linked	757	0.72
chr11_61792453_61792604	0.97	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	57075	0.08
chr21_32555155_32555306	0.96	TIAM1	T-cell lymphoma invasion and metastasis 1	52691	0.16
chr16_71935673_71935824	0.96	IST1	increased sodium tolerance 1 homolog (yeast)	6256	0.13
chr17_75955874_75956555	0.95	ENSG00000238898	.	40034	0.14
chr2_240358690_240358841	0.95	AC062017.1	Uncharacterized protein	35266	0.16
chr21_32532372_32532523	0.95	TIAM1	T-cell lymphoma invasion and metastasis 1	29908	0.23
chr12_23989337_23989488	0.95	SOX5	SRY (sex determining region Y)-box 5	59548	0.17
chr1_182557547_182558022	0.95	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	607	0.77
chr4_39032194_39032374	0.95	TMEM156	transmembrane protein 156	1757	0.38
chr17_264289_264440	0.94	AC108004.3		550	0.69
chr2_28826434_28826585	0.94	PLB1	phospholipase B1	1723	0.42
chr4_36245078_36245884	0.94	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr14_50053552_50053772	0.93	RN7SL1	RNA, 7SL, cytoplasmic 1	364	0.55
chr3_108543496_108543820	0.92	TRAT1	T cell receptor associated transmembrane adaptor 1	2039	0.42
chr2_68379959_68380110	0.92	WDR92	WD repeat domain 92	4571	0.18
chr7_106822662_106822813	0.92	HBP1	HMG-box transcription factor 1	2374	0.31
chr13_45991538_45991858	0.91	SLC25A30	solute carrier family 25, member 30	811	0.6
chr8_134086469_134086645	0.91	SLA	Src-like-adaptor	13954	0.23
chr16_86638626_86639076	0.91	FOXL1	forkhead box L1	26736	0.16
chr1_150547532_150547683	0.90	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	4399	0.09
chr14_92339571_92339902	0.90	FBLN5	fibulin 5	4650	0.23
chr19_48948815_48949184	0.90	GRWD1	glutamate-rich WD repeat containing 1	31	0.95
chr6_106964742_106964893	0.89	AIM1	absent in melanoma 1	5087	0.23
chr5_39186752_39186903	0.89	FYB	FYN binding protein	16302	0.26
chr14_61809095_61809246	0.89	PRKCH	protein kinase C, eta	1790	0.38
chr17_47766049_47766200	0.89	SPOP	speckle-type POZ protein	10528	0.14
chr2_225809390_225809894	0.89	DOCK10	dedicator of cytokinesis 10	2140	0.45
chr2_68594752_68594961	0.88	AC015969.3		2140	0.26
chr5_119523820_119523971	0.87	ENSG00000251975	.	149453	0.05
chr1_145396692_145396864	0.87	ENSG00000201558	.	14021	0.13
chr4_170948119_170948336	0.86	MFAP3L	microfibrillar-associated protein 3-like	134	0.97
chr2_238893215_238893433	0.86	UBE2F	ubiquitin-conjugating enzyme E2F (putative)	11587	0.2
chr3_194821900_194822051	0.86	XXYLT1-AS1	XXYLT1 antisense RNA 1	6658	0.17
chr6_41528112_41529137	0.85	FOXP4	forkhead box P4	4863	0.19
chr8_27131821_27132033	0.85	STMN4	stathmin-like 4	15990	0.18
chr22_17587383_17587676	0.85	CECR6	cat eye syndrome chromosome region, candidate 6	14614	0.14
chr7_105954307_105954458	0.85	NAMPT	nicotinamide phosphoribosyltransferase	27610	0.2
chr6_26473866_26474148	0.84	BTN2A1	butyrophilin, subfamily 2, member A1	8552	0.12
chr14_35344279_35344957	0.84	BAZ1A	bromodomain adjacent to zinc finger domain, 1A	235	0.86
chr11_46141542_46141818	0.84	PHF21A	PHD finger protein 21A	267	0.92
chr7_150414678_150414897	0.84	GIMAP1	GTPase, IMAP family member 1	1142	0.45
chr3_152098140_152098291	0.83	MBNL1	muscleblind-like splicing regulator 1	34632	0.17
chr11_47535258_47535409	0.83	RP11-750H9.7		1108	0.33
chr9_135644688_135645326	0.82	RP11-295G24.5		592	0.77
chr13_46750713_46750932	0.81	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	5637	0.17
chr12_82826657_82826808	0.81	METTL25	methyltransferase like 25	33594	0.21
chr16_48642312_48642839	0.81	N4BP1	NEDD4 binding protein 1	1545	0.4
chr22_26968957_26969108	0.81	TPST2	tyrosylprotein sulfotransferase 2	7340	0.16
chr6_36561394_36561869	0.81	SRSF3	serine/arginine-rich splicing factor 3	514	0.74
chr1_198652510_198652661	0.80	RP11-553K8.5		16395	0.24
chr3_108549304_108549455	0.80	TRAT1	T cell receptor associated transmembrane adaptor 1	7760	0.27
chr12_47604114_47604265	0.80	PCED1B	PC-esterase domain containing 1B	5863	0.23
chr6_32158116_32158500	0.80	PBX2	pre-B-cell leukemia homeobox 2	345	0.7
chr11_104915569_104916017	0.80	CARD16	caspase recruitment domain family, member 16	241	0.92
chr14_71454929_71455080	0.80	PCNX	pecanex homolog (Drosophila)	24744	0.26
chr12_120105804_120106659	0.80	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	562	0.74
chr15_101783225_101783409	0.79	CHSY1	chondroitin sulfate synthase 1	8820	0.18
chr6_138188643_138189747	0.79	RP11-356I2.4		175	0.8
chr5_67583406_67583557	0.79	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	715	0.8
chr10_7526759_7527322	0.78	ENSG00000207453	.	1731	0.45
chr10_677138_677289	0.78	RP11-809C18.3		2635	0.23
chr12_58229753_58229910	0.78	RP11-620J15.1		1044	0.32
chr1_192546230_192546423	0.78	RGS1	regulator of G-protein signaling 1	1423	0.45
chr12_12510418_12511218	0.78	LOH12CR1	loss of heterozygosity, 12, chromosomal region 1	466	0.63
chr3_151963279_151963566	0.78	MBNL1	muscleblind-like splicing regulator 1	22407	0.21
chr2_37576303_37576454	0.77	QPCT	glutaminyl-peptide cyclotransferase	4526	0.2
chr1_45284842_45285269	0.77	ENSG00000202444	.	614	0.49
chr1_162205339_162205490	0.77	ENSG00000266144	.	78517	0.08
chr5_65223204_65223520	0.76	ERBB2IP	erbb2 interacting protein	761	0.73
chr16_71915132_71915582	0.76	RP11-498D10.3		819	0.43
chr17_78753891_78754042	0.76	RP11-28G8.1		25466	0.21
chr11_18035030_18035437	0.75	SERGEF	secretion regulating guanine nucleotide exchange factor	524	0.79
chr8_113941673_113941824	0.75	CSMD3	CUB and Sushi multiple domains 3	239477	0.02
chr7_130419036_130419854	0.75	KLF14	Kruppel-like factor 14	557	0.8
chr2_197662576_197662727	0.75	GTF3C3	general transcription factor IIIC, polypeptide 3, 102kDa	1732	0.37
chr3_114010788_114010939	0.74	TIGIT	T cell immunoreceptor with Ig and ITIM domains	914	0.57
chr10_114291692_114291843	0.74	VTI1A	vesicle transport through interaction with t-SNAREs 1A	84751	0.08
chr10_129861850_129862130	0.74	PTPRE	protein tyrosine phosphatase, receptor type, E	16156	0.26
chr5_34007564_34007777	0.74	AMACR	alpha-methylacyl-CoA racemase	463	0.82
chr5_130881277_130881428	0.73	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	12626	0.29
chr1_118149801_118150025	0.73	FAM46C	family with sequence similarity 46, member C	1357	0.38
chrX_77361291_77361714	0.73	PGK1	phosphoglycerate kinase 1	357	0.91
chr5_154320356_154320564	0.73	MRPL22	mitochondrial ribosomal protein L22	170	0.94
chr9_93565170_93565321	0.73	SYK	spleen tyrosine kinase	1036	0.71
chr5_147777569_147777818	0.72	FBXO38	F-box protein 38	3418	0.21
chr22_18260542_18260943	0.72	BID	BH3 interacting domain death agonist	3311	0.23
chr19_13208223_13208471	0.72	LYL1	lymphoblastic leukemia derived sequence 1	5334	0.11
chr1_186292481_186292673	0.72	ENSG00000202025	.	11517	0.17
chr13_46752366_46752713	0.72	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	3920	0.19
chr15_64767992_64768143	0.72	RP11-702L15.4		5615	0.15
chr14_70110947_70111098	0.72	KIAA0247	KIAA0247	32709	0.18
chr5_90677126_90677416	0.72	ARRDC3	arrestin domain containing 3	1905	0.43
chr1_198615140_198615291	0.72	PTPRC	protein tyrosine phosphatase, receptor type, C	6923	0.25
chr9_131790875_131791069	0.72	SH3GLB2	SH3-domain GRB2-like endophilin B2	393	0.79
chr7_21472009_21472160	0.71	SP4	Sp4 transcription factor	4423	0.22
chr12_105035462_105035613	0.71	ENSG00000264295	.	50126	0.15
chr1_246488003_246488154	0.71	SMYD3-IT1	SMYD3 intronic transcript 1 (non-protein coding)	2338	0.35
chr3_36504651_36504802	0.71	STAC	SH3 and cysteine rich domain	82661	0.11
chr6_10838922_10839120	0.71	MAK	male germ cell-associated kinase	257	0.91
chr14_91716631_91716782	0.70	GPR68	G protein-coupled receptor 68	3518	0.21
chr1_29253817_29254129	0.70	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr22_31615175_31615326	0.70	ENSG00000199695	.	3589	0.13
chr15_43531850_43532099	0.70	ENSG00000202211	.	7904	0.13
chr18_74837172_74837323	0.70	MBP	myelin basic protein	2421	0.42
chrX_78400540_78401325	0.69	GPR174	G protein-coupled receptor 174	25537	0.27
chr10_63999686_63999837	0.69	RTKN2	rhotekin 2	3739	0.34
chr2_24298642_24299205	0.69	SF3B14	Pre-mRNA branch site protein p14	390	0.77
chr6_10528391_10528633	0.69	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	77	0.97
chr5_172482674_172483025	0.69	CREBRF	CREB3 regulatory factor	506	0.74
chr11_104904746_104905919	0.68	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chr6_149663878_149664029	0.68	TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	21765	0.18
chr11_640631_640896	0.68	DRD4	dopamine receptor D4	3470	0.1
chr12_110432591_110433205	0.67	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	1131	0.48
chrX_84258496_84258805	0.67	APOOL	apolipoprotein O-like	182	0.97
chr1_231552892_231553050	0.67	EGLN1	egl-9 family hypoxia-inducible factor 1	7819	0.23
chr11_40120739_40120890	0.67	LRRC4C	leucine rich repeat containing 4C	142619	0.05
chr7_99697639_99698087	0.67	MCM7	minichromosome maintenance complex component 7	517	0.45
chr19_54465805_54465956	0.67	CACNG8	calcium channel, voltage-dependent, gamma subunit 8	414	0.72
chr1_10754337_10754512	0.67	CASZ1	castor zinc finger 1	49291	0.13
chr12_66583583_66583798	0.67	IRAK3	interleukin-1 receptor-associated kinase 3	653	0.67
chr6_6891112_6891263	0.66	ENSG00000240936	.	47943	0.18
chrX_117750069_117750220	0.66	ENSG00000206862	.	46666	0.16
chr5_130882612_130883040	0.66	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr7_104909608_104910184	0.66	SRPK2	SRSF protein kinase 2	434	0.86
chr22_21273701_21274522	0.66	CRKL	v-crk avian sarcoma virus CT10 oncogene homolog-like	2397	0.18
chr8_48648492_48649280	0.65	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	2762	0.26
chr7_139555611_139555822	0.65	TBXAS1	thromboxane A synthase 1 (platelet)	26606	0.23
chr1_24862040_24862255	0.65	ENSG00000266551	.	5943	0.18
chr19_52799783_52800008	0.65	ZNF480	zinc finger protein 480	535	0.56
chr1_185126672_185127282	0.65	SWT1	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	363	0.75
chr15_55489355_55489882	0.65	RSL24D1	ribosomal L24 domain containing 1	353	0.91
chr19_51642158_51642309	0.65	SIGLEC7	sialic acid binding Ig-like lectin 7	3323	0.11
chr2_175458036_175458370	0.64	WIPF1	WAS/WASL interacting protein family, member 1	4290	0.21
chr16_10838130_10838300	0.64	NUBP1	nucleotide binding protein 1	503	0.79
chr13_41236803_41237000	0.64	FOXO1	forkhead box O1	3833	0.29
chr8_39797291_39797650	0.64	IDO2	indoleamine 2,3-dioxygenase 2	4996	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	3.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.3	1.7	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.3	2.9	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.3	0.8	GO:0010040	response to iron(II) ion(GO:0010040)
0.2	1.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.2	0.7	GO:0030210	heparin biosynthetic process(GO:0030210)
0.2	0.6	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.2	0.6	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.2	0.6	GO:0032632	interleukin-3 production(GO:0032632)
0.2	1.1	GO:0002507	tolerance induction(GO:0002507)
0.2	0.5	GO:0006772	thiamine metabolic process(GO:0006772)
0.2	0.4	GO:1901419	regulation of response to alcohol(GO:1901419)
0.2	0.5	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.2	0.5	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.2	0.6	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.1	0.4	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.4	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.4	GO:0071569	protein ufmylation(GO:0071569)
0.1	0.7	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	0.4	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.8	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	0.4	GO:0006667	sphinganine metabolic process(GO:0006667)
0.1	0.6	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.1	0.1	GO:0071025	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1	0.5	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1	0.4	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.1	0.9	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	0.3	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	0.5	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.3	GO:0060789	hair follicle placode formation(GO:0060789)
0.1	0.3	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.1	0.9	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	1.5	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.1	0.8	GO:0015671	oxygen transport(GO:0015671)
0.1	0.2	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1	0.3	GO:0009174	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1	0.9	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.1	0.3	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.1	0.4	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.1	0.4	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	0.4	GO:0022614	membrane to membrane docking(GO:0022614)
0.1	0.3	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1	0.2	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.1	0.6	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.2	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.1	0.4	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.3	GO:0090224	regulation of spindle organization(GO:0090224)
0.1	0.4	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.1	0.6	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.1	0.9	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.1	0.4	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.1	0.3	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.6	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.2	GO:0002691	regulation of cellular extravasation(GO:0002691) positive regulation of cellular extravasation(GO:0002693)
0.1	0.3	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.1	0.1	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.1	0.4	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.1	0.2	GO:0032543	mitochondrial translation(GO:0032543)
0.1	0.3	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1	0.1	GO:0046398	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.1	0.2	GO:0097576	vacuole fusion(GO:0097576)
0.1	0.4	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1	0.2	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.1	0.2	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.3	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1	0.3	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.1	0.4	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.1	0.2	GO:0060972	left/right pattern formation(GO:0060972)
0.1	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1	0.2	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.1	0.2	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.1	0.3	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.1	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.1	0.2	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.1	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.2	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1	0.4	GO:0021591	ventricular system development(GO:0021591)
0.1	0.4	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.3	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.3	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.1	0.2	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	0.4	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.1	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.6	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.2	GO:0001714	endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.5	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.1	0.2	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1	0.2	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.1	0.5	GO:0009650	UV protection(GO:0009650)
0.1	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.1	0.3	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	0.2	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.1	0.2	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.1	0.3	GO:0060055	angiogenesis involved in wound healing(GO:0060055)
0.1	0.2	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.1	0.7	GO:0006024	glycosaminoglycan biosynthetic process(GO:0006024)
0.1	0.6	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.5	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.2	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.2	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.3	GO:0048617	foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.3	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	1.3	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.6	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.5	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.3	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.0	GO:0050765	regulation of B cell apoptotic process(GO:0002902) negative regulation of phagocytosis(GO:0050765)
0.0	0.3	GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.2	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.4	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.0	GO:0051023	immunoglobulin secretion(GO:0048305) regulation of immunoglobulin secretion(GO:0051023)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.2	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.9	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.1	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.2	GO:0010561	negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0	0.1	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.1	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.2	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.4	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	3.6	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.4	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:1903306	negative regulation of regulated secretory pathway(GO:1903306)
0.0	0.3	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.4	GO:0050718	positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0	0.1	GO:2000403	T cell chemotaxis(GO:0010818) regulation of T cell chemotaxis(GO:0010819) positive regulation of T cell chemotaxis(GO:0010820) T cell migration(GO:0072678) regulation of lymphocyte chemotaxis(GO:1901623) regulation of lymphocyte migration(GO:2000401) positive regulation of lymphocyte migration(GO:2000403) regulation of T cell migration(GO:2000404) positive regulation of T cell migration(GO:2000406)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.4	GO:0050482	arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0	0.0	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.1	GO:0034728	nucleosome organization(GO:0034728)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.5	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.2	GO:0034311	sphingosine metabolic process(GO:0006670) diol metabolic process(GO:0034311)
0.0	0.6	GO:0006308	DNA catabolic process(GO:0006308)
0.0	0.8	GO:0050709	negative regulation of protein secretion(GO:0050709)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.2	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.3	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.2	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.7	GO:0007566	embryo implantation(GO:0007566)
0.0	0.1	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.2	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.2	GO:0045123	cellular extravasation(GO:0045123)
0.0	0.2	GO:0051642	centrosome localization(GO:0051642)
0.0	0.3	GO:0006301	postreplication repair(GO:0006301)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.3	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.3	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.6	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.7	GO:1901185	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.6	GO:0007032	endosome organization(GO:0007032)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.3	GO:0033003	regulation of mast cell activation(GO:0033003)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.8	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.4	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0010225	response to UV-C(GO:0010225)
0.0	0.2	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.0	0.4	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	1.6	GO:0070646	protein modification by small protein removal(GO:0070646)
0.0	0.8	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.3	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.3	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	1.1	GO:0006094	gluconeogenesis(GO:0006094)
0.0	0.2	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518) negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.2	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.7	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.0	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	1.0	GO:0006333	chromatin assembly or disassembly(GO:0006333)
0.0	0.4	GO:0046320	regulation of fatty acid oxidation(GO:0046320)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.2	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	1.3	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0019319	hexose biosynthetic process(GO:0019319)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0045329	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.4	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0032418	lysosome localization(GO:0032418)
0.0	0.0	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.3	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.5	GO:0043928	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.0	GO:0052031	modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0	0.2	GO:0034375	high-density lipoprotein particle remodeling(GO:0034375)
0.0	0.6	GO:0006338	chromatin remodeling(GO:0006338)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0071364	response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.2	GO:0031663	lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	5.0	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.6	GO:0033572	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	1.1	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.2	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0051873	disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0	0.1	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.2	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0032647	interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.2	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.1	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	1.7	GO:0018196	peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.1	GO:0006586	tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0000050	urea cycle(GO:0000050)
0.0	0.0	GO:0034123	positive regulation of toll-like receptor signaling pathway(GO:0034123)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.0	GO:2000398	regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.0	GO:0042090	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.2	GO:0001510	RNA methylation(GO:0001510)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.6	GO:0072655	establishment of protein localization to mitochondrion(GO:0072655)
0.0	0.1	GO:0045923	positive regulation of fatty acid metabolic process(GO:0045923)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.2	GO:0006903	vesicle targeting(GO:0006903)
0.0	2.7	GO:0000375	RNA splicing, via transesterification reactions(GO:0000375)
0.0	0.2	GO:0032092	positive regulation of protein binding(GO:0032092)
0.0	0.2	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0010922	positive regulation of phosphatase activity(GO:0010922)
0.0	0.0	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.1	GO:0021936	regulation of cerebellar granule cell precursor proliferation(GO:0021936) cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0	0.0	GO:0070977	ossification involved in bone maturation(GO:0043931) organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0048668	collateral sprouting(GO:0048668) regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.0	GO:0043558	regulation of translational initiation in response to stress(GO:0043558)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.2	GO:0051156	glucose 6-phosphate metabolic process(GO:0051156)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.4	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.8	GO:0071158	positive regulation of cell cycle arrest(GO:0071158)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.3	GO:0051693	actin filament capping(GO:0051693)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.5	GO:0031397	negative regulation of protein ubiquitination(GO:0031397)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.0	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0010591	regulation of lamellipodium assembly(GO:0010591)
0.0	0.0	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0	0.1	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.1	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881)
0.0	0.0	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.3	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.3	GO:0042552	myelination(GO:0042552)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	0.0	GO:0052312	modulation of transcription in other organism involved in symbiotic interaction(GO:0052312)
0.0	0.7	GO:0042113	B cell activation(GO:0042113)
0.0	0.0	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.0	GO:0060431	primary lung bud formation(GO:0060431)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.0	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.2	GO:0080171	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0	0.4	GO:0009060	aerobic respiration(GO:0009060)
0.0	0.0	GO:0000154	rRNA modification(GO:0000154)
0.0	0.1	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.1	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.2	GO:0009267	cellular response to starvation(GO:0009267)
0.0	0.1	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.0	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament organization(GO:0031033) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.3	GO:0006839	mitochondrial transport(GO:0006839)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.2	GO:0007030	Golgi organization(GO:0007030)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.0	GO:0060487	lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.0	0.0	GO:0060346	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0	0.1	GO:0051453	regulation of intracellular pH(GO:0051453)
0.0	0.2	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	0.0	GO:0015669	gas transport(GO:0015669)
0.0	0.2	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.0	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0030431	sleep(GO:0030431)
0.0	0.0	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0	0.5	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0	0.0	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0	0.1	GO:0046677	response to antibiotic(GO:0046677)
0.0	1.1	GO:0042254	ribosome biogenesis(GO:0042254)
0.0	0.1	GO:0009713	catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.0	0.0	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.6	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0	0.1	GO:0042752	regulation of circadian rhythm(GO:0042752)
0.0	0.0	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:0014044	Schwann cell development(GO:0014044) myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.0	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.2	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.3	GO:0048709	oligodendrocyte differentiation(GO:0048709)
0.0	0.0	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0000216	obsolete M/G1 transition of mitotic cell cycle(GO:0000216)
0.0	0.2	GO:0016571	histone methylation(GO:0016571)
0.0	0.0	GO:0021683	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.0	GO:0019730	antimicrobial humoral response(GO:0019730)
0.0	0.7	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.0	GO:0030157	pancreatic juice secretion(GO:0030157)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.2	GO:0051225	spindle assembly(GO:0051225)
0.0	0.0	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.0	GO:0043631	RNA polyadenylation(GO:0043631)
0.0	0.0	GO:0033151	V(D)J recombination(GO:0033151)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.6	GO:0019083	viral gene expression(GO:0019080) viral transcription(GO:0019083)
0.0	0.0	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0042516	regulation of tyrosine phosphorylation of Stat3 protein(GO:0042516)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:0019042	viral latency(GO:0019042)
0.0	0.2	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	0.3	GO:0097194	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) execution phase of apoptosis(GO:0097194)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.0	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0015793	glycerol transport(GO:0015793)
0.0	0.0	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.0	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.0	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253)
0.0	0.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.0	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.0	GO:0060456	positive regulation of digestive system process(GO:0060456)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.2	2.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.2	0.5	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.9	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	1.4	GO:0042101	T cell receptor complex(GO:0042101)
0.1	1.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.4	GO:0043218	compact myelin(GO:0043218)
0.1	0.5	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	0.8	GO:0031010	ISWI-type complex(GO:0031010)
0.1	0.4	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	0.3	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	0.6	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.3	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	0.3	GO:0072487	MSL complex(GO:0072487)
0.1	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.1	0.4	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	0.3	GO:0030904	retromer complex(GO:0030904)
0.1	0.5	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.1	0.3	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.1	0.8	GO:0001772	immunological synapse(GO:0001772)
0.1	0.4	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	0.3	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1	0.4	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	1.1	GO:0043073	germ cell nucleus(GO:0043073)
0.1	0.3	GO:0042788	polysomal ribosome(GO:0042788)
0.1	0.4	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.1	0.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.3	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1	0.3	GO:0001739	sex chromatin(GO:0001739)
0.1	0.7	GO:0005675	holo TFIIH complex(GO:0005675)
0.1	0.2	GO:0042629	mast cell granule(GO:0042629)
0.1	0.2	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.1	0.3	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.5	GO:0042555	MCM complex(GO:0042555)
0.1	0.2	GO:0001740	Barr body(GO:0001740)
0.1	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.1	2.8	GO:0000786	nucleosome(GO:0000786)
0.1	0.4	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.4	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.0	GO:0000791	euchromatin(GO:0000791)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.3	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.8	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	1.0	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.4	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.2	GO:0000125	PCAF complex(GO:0000125)
0.0	0.2	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.2	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.3	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.4	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0038201	TOR complex(GO:0038201)
0.0	0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.4	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.0	2.0	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	0.9	GO:0005902	microvillus(GO:0005902)
0.0	1.0	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.9	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	1.5	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.2	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.2	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.2	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.3	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	1.7	GO:0015934	large ribosomal subunit(GO:0015934)
0.0	0.5	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	1.6	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.7	GO:0030863	cortical cytoskeleton(GO:0030863)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.8	GO:0015030	Cajal body(GO:0015030)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	1.0	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	1.2	GO:0005643	nuclear pore(GO:0005643)
0.0	0.1	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.3	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.2	GO:0016235	aggresome(GO:0016235)
0.0	2.2	GO:0005840	ribosome(GO:0005840)
0.0	0.3	GO:0031201	SNARE complex(GO:0031201)
0.0	0.2	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.3	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0032806	carboxy-terminal domain protein kinase complex(GO:0032806)
0.0	0.0	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.0	GO:0071547	piP-body(GO:0071547)
0.0	0.1	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	1.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.5	GO:0055037	recycling endosome(GO:0055037)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.3	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.5	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	1.3	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0	0.3	GO:0030666	endocytic vesicle membrane(GO:0030666)
0.0	0.1	GO:0005844	polysome(GO:0005844)
0.0	1.6	GO:0000785	chromatin(GO:0000785)
0.0	0.1	GO:0060293	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.0	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.0	GO:0044462	external encapsulating structure(GO:0030312) external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0001533	cornified envelope(GO:0001533)
0.0	0.9	GO:0010008	endosome membrane(GO:0010008)
0.0	1.1	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0	0.6	GO:0000502	proteasome complex(GO:0000502)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	5.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	0.2	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.8	GO:0016607	nuclear speck(GO:0016607)
0.0	2.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	0.1	GO:0005771	multivesicular body(GO:0005771)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.8	GO:0050544	arachidonic acid binding(GO:0050544)
0.4	2.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3	0.9	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3	0.9	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3	0.8	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2	0.8	GO:0045569	TRAIL binding(GO:0045569)
0.2	0.6	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.2	0.5	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.2	0.8	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2	0.5	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.4	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.1	0.4	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.1	0.4	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	0.9	GO:0043208	glycosphingolipid binding(GO:0043208)
0.1	0.3	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1	0.4	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.4	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	0.4	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.5	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.5	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.3	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.1	2.7	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	1.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	0.3	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.3	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.1	0.3	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.3	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.9	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1	1.3	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.1	0.6	GO:0016778	diphosphotransferase activity(GO:0016778)
0.1	1.1	GO:0016854	racemase and epimerase activity(GO:0016854)
0.1	1.5	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	0.5	GO:0001846	opsonin binding(GO:0001846)
0.1	0.4	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.3	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1	0.5	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.1	0.3	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.2	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.7	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.1	0.9	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.1	1.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.1	0.2	GO:0004370	glycerol kinase activity(GO:0004370)
0.1	0.3	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1	0.5	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.1	0.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.2	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1	0.5	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.4	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1	0.4	GO:0050786	RAGE receptor binding(GO:0050786)
0.1	0.2	GO:0016882	cyclo-ligase activity(GO:0016882)
0.1	0.4	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.4	GO:0030274	LIM domain binding(GO:0030274)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.2	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.2	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.1	1.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	1.0	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1	0.7	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.2	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.1	0.2	GO:0016531	copper chaperone activity(GO:0016531)
0.1	0.3	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	0.2	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.1	1.6	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	0.8	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.2	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.1	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.2	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1	0.9	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.1	1.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.9	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.8	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.5	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.3	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.4	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.3	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.8	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0	0.4	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.8	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0	0.4	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.2	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.4	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	1.2	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.9	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.1	GO:0035173	histone kinase activity(GO:0035173)
0.0	2.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.5	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.4	GO:0017069	snRNA binding(GO:0017069)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.6	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.0	0.4	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.2	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.3	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.2	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	1.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.5	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.4	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	1.5	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.2	GO:0051400	BH domain binding(GO:0051400)
0.0	1.1	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	1.5	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.2	GO:0045502	dynein binding(GO:0045502)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.2	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.4	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.4	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0004802	transketolase activity(GO:0004802)
0.0	1.4	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	0.8	GO:0019210	kinase inhibitor activity(GO:0019210)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.4	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	1.6	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.4	GO:0043621	protein self-association(GO:0043621)
0.0	0.0	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.2	GO:0031543	peptidyl-proline dioxygenase activity(GO:0031543)
0.0	0.3	GO:0004659	prenyltransferase activity(GO:0004659)
0.0	0.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.8	GO:0016860	intramolecular oxidoreductase activity(GO:0016860)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.5	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.3	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	2.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0005351	sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.6	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.2	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.2	GO:0016289	CoA hydrolase activity(GO:0016289)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.0	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.8	GO:0051015	actin filament binding(GO:0051015)
0.0	0.2	GO:0016755	transferase activity, transferring amino-acyl groups(GO:0016755)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.0	GO:0061733	peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0	1.0	GO:0008565	protein transporter activity(GO:0008565)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.4	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.0	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.2	GO:0043022	ribosome binding(GO:0043022)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.5	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	3.1	GO:0030695	GTPase regulator activity(GO:0030695)
0.0	0.4	GO:0019003	GDP binding(GO:0019003)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.2	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.0	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.1	GO:0003678	DNA helicase activity(GO:0003678)
0.0	0.2	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.1	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.3	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.0	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	1.3	GO:0003702	obsolete RNA polymerase II transcription factor activity(GO:0003702)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.0	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0019865	immunoglobulin binding(GO:0019865)
0.0	0.1	GO:0015248	sterol transporter activity(GO:0015248)
0.0	0.0	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.1	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.1	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0032451	demethylase activity(GO:0032451)
0.0	0.1	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	0.9	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	2.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	1.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	1.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	0.8	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.1	4.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	1.4	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	0.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	0.3	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	1.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	0.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	2.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	0.7	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.7	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.3	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.3	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.8	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.9	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	1.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.8	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.7	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.8	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.5	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.8	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.5	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.1	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.4	PID ATM PATHWAY	ATM pathway
0.0	0.2	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.9	PID E2F PATHWAY	E2F transcription factor network
0.0	0.6	PID ATR PATHWAY	ATR signaling pathway
0.0	0.6	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.6	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.2	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.3	PID FOXO PATHWAY	FoxO family signaling
0.0	0.1	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.4	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	0.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.2	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.0	PID SHP2 PATHWAY	SHP2 signaling
0.0	0.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.3	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	0.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	2.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	1.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	2.2	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.1	1.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	1.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	2.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.1	1.9	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	0.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	0.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	4.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	1.0	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	0.1	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.1	0.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	0.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	1.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	0.9	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	0.3	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	0.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	0.6	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.1	0.6	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	5.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	0.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	0.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1	1.3	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.1	0.4	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.1	0.7	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.1	0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.6	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.6	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.5	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	1.0	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.4	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.2	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.7	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.8	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	2.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.6	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.8	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.0	0.5	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.4	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	1.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.7	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.1	REACTOME ORC1 REMOVAL FROM CHROMATIN	Genes involved in Orc1 removal from chromatin
0.0	0.3	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.1	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.6	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.0	0.8	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.6	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.3	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.7	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.0	0.3	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0	0.0	REACTOME PLATELET HOMEOSTASIS	Genes involved in Platelet homeostasis
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.2	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0	0.8	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	0.3	REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	Genes involved in RNA Polymerase II Pre-transcription Events
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.9	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.2	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.0	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.4	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	2.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.1	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	1.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.3	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.1	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.6	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	1.5	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	0.2	REACTOME INTERFERON SIGNALING	Genes involved in Interferon Signaling
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.8	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	0.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.1	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	0.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	0.0	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.0	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.0	0.4	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	1.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.1	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.2	REACTOME REGULATION OF MITOTIC CELL CYCLE	Genes involved in Regulation of mitotic cell cycle
0.0	0.1	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.0	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.44

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif across conditions

Conditions sorted by the z-value of the OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: