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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for OTX2_CRX

Z-value: 0.60

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Transcription factors associated with OTX2_CRX

Gene Symbol Gene ID Gene Info
OTX2
ENSG00000165588.12 OTX2
CRX
ENSG00000105392.11 CRX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
OTX2chr14_57274863_5727515021600.2603730.646.3e-02Click!
OTX2chr14_57275358_5727554317160.3094140.452.2e-01Click!
OTX2chr14_57264424_5726457578670.170193-0.363.4e-01Click!
OTX2chr14_57274118_5727426918120.3003790.284.6e-01Click!
OTX2chr14_57274481_5727463221750.2604770.235.4e-01Click!

Activity of the OTX2_CRX motif across conditions

Conditions sorted by the z-value of the OTX2_CRX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr15_89914451_89914936 0.11 ENSG00000207819
 .
 3445
 0.23
chrX_34671991_34672311 0.10 TMEM47
 transmembrane protein 47
 3254
 0.41
chr2_36585229_36585663 0.10 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 1832
 0.5
chr8_58907686_58908288 0.10 FAM110B
 family with sequence similarity 110, member B
 874
 0.76
chr3_49169788_49170138 0.10 LAMB2
 laminin, beta 2 (laminin S)
 490
 0.65
chr9_90588787_90589959 0.09 CDK20
 cyclin-dependent kinase 20
 29
 0.98
chr5_3598562_3598819 0.09 CTD-2012M11.3
1612
 0.42
chr3_123518515_123518699 0.09 MYLK
 myosin light chain kinase
 5919
 0.23
chr4_112600114_112600265 0.08 ENSG00000200963
 .
 347621
 0.01
chr2_12842465_12842741 0.08 TRIB2
 tribbles pseudokinase 2
 14412
 0.26
chrX_99899847_99900028 0.08 SRPX2
 sushi-repeat containing protein, X-linked 2
 722
 0.65
chr14_27065271_27065422 0.08 NOVA1
 neuro-oncological ventral antigen 1
 65
 0.96
chr11_130320694_130320845 0.08 ADAMTS15
 ADAM metallopeptidase with thrombospondin type 1 motif, 15
 1900
 0.41
chr4_75718841_75720131 0.08 BTC
 betacellulin
 410
 0.91
chr13_65834890_65835427 0.08 ENSG00000221685
 .
 603147
 0.0
chr14_53301814_53302501 0.08 FERMT2
 fermitin family member 2
 29082
 0.15
chr6_26575872_26576023 0.08 ABT1
 activator of basal transcription 1
 21233
 0.14
chr19_6740138_6741070 0.07 TRIP10
 thyroid hormone receptor interactor 10
 325
 0.81
chr1_114522384_114522566 0.07 OLFML3
 olfactomedin-like 3
 220
 0.93
chr16_75232194_75232506 0.07 CTRB2
 chymotrypsinogen B2
 7343
 0.14
chr16_54969072_54969449 0.07 IRX5
 iroquois homeobox 5
 3276
 0.4
chr3_155109533_155109828 0.07 ENSG00000272096
 .
 45932
 0.16
chr7_73867713_73868217 0.07 GTF2IRD1
 GTF2I repeat domain containing 1
 155
 0.96
chr2_170366040_170366191 0.07 KLHL41
 kelch-like family member 41
 97
 0.97
chr6_46458168_46458592 0.07 RCAN2
 regulator of calcineurin 2
 719
 0.62
chr3_87040086_87040946 0.07 VGLL3
 vestigial like 3 (Drosophila)
 247
 0.96
chr13_34250323_34250584 0.07 RFC3
 replication factor C (activator 1) 3, 38kDa
 141733
 0.05
chr16_28549300_28549715 0.07 NUPR1
 nuclear protein, transcriptional regulator, 1
 822
 0.5
chr8_136478593_136478847 0.07 KHDRBS3
 KH domain containing, RNA binding, signal transduction associated 3
 7770
 0.25
chr22_31198410_31198813 0.07 OSBP2
 oxysterol binding protein 2
 462
 0.84
chr20_49307514_49308405 0.07 FAM65C
 family with sequence similarity 65, member C
 43
 0.97
chr1_235795999_235796340 0.07 GNG4
 guanine nucleotide binding protein (G protein), gamma 4
 17124
 0.25
chr5_9546839_9547056 0.07 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 760
 0.6
chr7_93552303_93552503 0.07 GNG11
 guanine nucleotide binding protein (G protein), gamma 11
 1392
 0.38
chr16_54970178_54971110 0.07 IRX5
 iroquois homeobox 5
 4660
 0.36
chr15_38547303_38547454 0.07 SPRED1
 sprouty-related, EVH1 domain containing 1
 1996
 0.49
chr19_10444919_10445184 0.07 ICAM3
 intercellular adhesion molecule 3
 348
 0.62
chr8_55294582_55295235 0.07 ENSG00000244107
 .
 38120
 0.17
chr9_89049166_89049463 0.07 ENSG00000222293
 .
 11271
 0.28
chr1_215257188_215257339 0.07 KCNK2
 potassium channel, subfamily K, member 2
 403
 0.92
chr12_81102183_81102935 0.07 MYF6
 myogenic factor 6 (herculin)
 1282
 0.49
chr10_97049818_97050125 0.07 PDLIM1
 PDZ and LIM domain 1
 810
 0.7
chr6_35286420_35286751 0.07 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 9070
 0.18
chr18_20746992_20747143 0.07 CABLES1
 Cdk5 and Abl enzyme substrate 1
 11278
 0.21
chr12_3308931_3310293 0.07 TSPAN9
 tetraspanin 9
 729
 0.75
chr18_53530407_53530634 0.07 TCF4
 transcription factor 4
 198502
 0.03
chr10_95848621_95848951 0.07 PLCE1
 phospholipase C, epsilon 1
 44
 0.97
chr3_28383486_28383637 0.07 AZI2
 5-azacytidine induced 2
 6407
 0.24
chr10_77159524_77159700 0.06 ENSG00000237149
 .
 1665
 0.33
chr12_1427708_1428104 0.06 RP5-951N9.2
67093
 0.11
chr1_164531408_164531670 0.06 PBX1
 pre-B-cell leukemia homeobox 1
 503
 0.87
chr1_8772244_8772432 0.06 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 9060
 0.25
chr1_91191218_91191722 0.06 BARHL2
 BarH-like homeobox 2
 8676
 0.3
chr10_119303944_119304573 0.06 EMX2OS
 EMX2 opposite strand/antisense RNA
 321
 0.88
chr3_112359594_112359745 0.06 CCDC80
 coiled-coil domain containing 80
 447
 0.87
chr14_35179773_35180008 0.06 CFL2
 cofilin 2 (muscle)
 3144
 0.26
chr2_176987899_176988234 0.06 HOXD9
 homeobox D9
 978
 0.29
chr4_164253766_164254020 0.06 NPY1R
 neuropeptide Y receptor Y1
 121
 0.97
chr12_91576386_91576586 0.06 DCN
 decorin
 0
 0.99
chr2_164591967_164592245 0.06 FIGN
 fidgetin
 411
 0.92
chr17_762649_762818 0.06 NXN
 nucleoredoxin
 4604
 0.18
chr1_39735914_39736147 0.06 MACF1
 microtubule-actin crosslinking factor 1
 1831
 0.35
chr18_12309515_12309681 0.06 TUBB6
 tubulin, beta 6 class V
 1336
 0.41
chr15_65901005_65901156 0.06 VWA9
 von Willebrand factor A domain containing 9
 2327
 0.2
chr2_216299709_216300678 0.06 FN1
 fibronectin 1
 597
 0.55
chr13_30276703_30277107 0.06 SLC7A1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 107080
 0.07
chr8_99963595_99963771 0.06 OSR2
 odd-skipped related transciption factor 2
 3063
 0.23
chr9_73483972_73484180 0.06 TRPM3
 transient receptor potential cation channel, subfamily M, member 3
 102
 0.98
chr20_19974216_19974491 0.06 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 23407
 0.19
chr15_32933967_32934156 0.06 SCG5
 secretogranin V (7B2 protein)
 158
 0.94
chr2_216298025_216298259 0.06 FN1
 fibronectin 1
 2648
 0.29
chr1_92907603_92907960 0.06 ENSG00000242764
 .
 39539
 0.16
chr13_114792883_114793184 0.06 RASA3
 RAS p21 protein activator 3
 50405
 0.16
chr2_207307729_207308161 0.06 ADAM23
 ADAM metallopeptidase domain 23
 318
 0.92
chr6_113953461_113953992 0.06 ENSG00000266650
 .
 29609
 0.21
chr13_36704166_36704317 0.06 DCLK1
 doublecortin-like kinase 1
 1202
 0.59
chrX_3263508_3263724 0.06 MXRA5
 matrix-remodelling associated 5
 1066
 0.64
chr7_55089371_55089524 0.06 EGFR
 epidermal growth factor receptor
 2636
 0.41
chr6_128977127_128977410 0.06 ENSG00000238938
 .
 42922
 0.16
chr16_55090478_55090815 0.06 IRX5
 iroquois homeobox 5
 124662
 0.06
chr19_46286294_46286481 0.06 DMPK
 dystrophia myotonica-protein kinase
 640
 0.45
chr22_38657243_38657394 0.06 TMEM184B
 transmembrane protein 184B
 11352
 0.11
chr15_95217234_95217771 0.06 MCTP2
 multiple C2 domains, transmembrane 2
 318299
 0.01
chr1_75138923_75139762 0.06 C1orf173
 chromosome 1 open reading frame 173
 80
 0.98
chr5_9544908_9545592 0.06 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 937
 0.56
chr5_95950045_95950381 0.06 ENSG00000238518
 .
 24233
 0.16
chr11_125497097_125497248 0.06 CHEK1
 checkpoint kinase 1
 529
 0.7
chr3_170132220_170132371 0.06 CLDN11
 claudin 11
 4358
 0.29
chr4_115520348_115520872 0.06 UGT8
 UDP glycosyltransferase 8
 684
 0.8
chr3_112961154_112961680 0.06 BOC
 BOC cell adhesion associated, oncogene regulated
 26219
 0.19
chr3_123168721_123169253 0.06 ADCY5
 adenylate cyclase 5
 382
 0.9
chr4_150453103_150453254 0.06 ENSG00000202331
 .
 375534
 0.01
chr12_50636266_50636502 0.06 LIMA1
 LIM domain and actin binding 1
 7292
 0.13
chr15_35949903_35950054 0.06 DPH6
 diphthamine biosynthesis 6
 111585
 0.07
chr16_53086342_53086851 0.06 RP11-467J12.4
189
 0.95
chr7_143579344_143579634 0.06 FAM115A
 family with sequence similarity 115, member A
 487
 0.8
chr15_23931247_23932124 0.06 NDN
 necdin, melanoma antigen (MAGE) family member
 765
 0.7
chr11_19420110_19420332 0.06 ENSG00000200687
 .
 3307
 0.25
chr9_109624363_109624788 0.06 ZNF462
 zinc finger protein 462
 803
 0.69
chr7_19408295_19408500 0.06 FERD3L
 Fer3-like bHLH transcription factor
 223353
 0.02
chr4_152148784_152149033 0.06 SH3D19
 SH3 domain containing 19
 274
 0.93
chr1_154941803_154941985 0.06 SHC1
 SHC (Src homology 2 domain containing) transforming protein 1
 525
 0.53
chr2_19557855_19558307 0.06 OSR1
 odd-skipped related transciption factor 1
 333
 0.92
chr9_89559920_89560071 0.06 GAS1
 growth arrest-specific 1
 2109
 0.48
chr5_3597166_3597716 0.06 IRX1
 iroquois homeobox 1
 1273
 0.51
chr1_151953452_151953706 0.06 S100A10
 S100 calcium binding protein A10
 11475
 0.14
chr8_93115764_93116215 0.06 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
 475
 0.9
chr1_180882927_180883078 0.06 KIAA1614
 KIAA1614
 677
 0.71
chr9_91568737_91568931 0.06 C9orf47
 chromosome 9 open reading frame 47
 36944
 0.17
chr13_80824030_80824188 0.06 SPRY2
 sprouty homolog 2 (Drosophila)
 89685
 0.1
chr18_2906194_2907483 0.06 RP11-737O24.5
14126
 0.16
chr3_65583777_65583941 0.06 MAGI1
 membrane associated guanylate kinase, WW and PDZ domain containing 1
 298
 0.95
chr6_3517843_3518042 0.06 SLC22A23
 solute carrier family 22, member 23
 60686
 0.14
chr1_162582264_162582415 0.06 DDR2
 discoidin domain receptor tyrosine kinase 2
 18824
 0.16
chr2_217180593_217180957 0.06 AC069155.1
12727
 0.18
chr13_76361393_76361544 0.06 LMO7
 LIM domain 7
 1506
 0.51
chr3_55519561_55519953 0.06 WNT5A
 wingless-type MMTV integration site family, member 5A
 1574
 0.4
chr1_8433877_8434267 0.06 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 9174
 0.19
chr1_157986336_157986537 0.05 KIRREL-IT1
 KIRREL intronic transcript 1 (non-protein coding)
 8904
 0.22
chr17_78044749_78045392 0.05 CCDC40
 coiled-coil domain containing 40
 12346
 0.15
chr6_147235797_147235979 0.05 STXBP5-AS1
 STXBP5 antisense RNA 1
 1133
 0.66
chr2_11051733_11051998 0.05 KCNF1
 potassium voltage-gated channel, subfamily F, member 1
 198
 0.95
chr10_98272514_98273588 0.05 TLL2
 tolloid-like 2
 617
 0.79
chr15_62862079_62862274 0.05 TLN2
 talin 2
 8612
 0.27
chr5_88178054_88178448 0.05 MEF2C
 myocyte enhancer factor 2C
 713
 0.52
chr16_88450130_88450579 0.05 ZNF469
 zinc finger protein 469
 43525
 0.15
chr8_38965103_38965508 0.05 ADAM32
 ADAM metallopeptidase domain 32
 13
 0.98
chr4_187901481_187901677 0.05 ENSG00000252382
 .
 122969
 0.06
chr7_94536809_94537187 0.05 PPP1R9A
 protein phosphatase 1, regulatory subunit 9A
 11
 0.99
chr1_215740105_215740888 0.05 KCTD3
 potassium channel tetramerization domain containing 3
 239
 0.96
chr1_170851017_170851182 0.05 MROH9
 maestro heat-like repeat family member 9
 53513
 0.16
chr8_121137253_121137925 0.05 COL14A1
 collagen, type XIV, alpha 1
 237
 0.96
chr2_235541588_235541739 0.05 ARL4C
 ADP-ribosylation factor-like 4C
 135966
 0.05
chr9_109876632_109876800 0.05 RP11-508N12.2
11447
 0.29
chr2_198909706_198909857 0.05 PLCL1
 phospholipase C-like 1
 38755
 0.22
chr2_175711229_175711408 0.05 CHN1
 chimerin 1
 175
 0.97
chr14_95949817_95950024 0.05 SYNE3
 spectrin repeat containing, nuclear envelope family member 3
 7747
 0.18
chr18_8707466_8707765 0.05 RP11-674N23.1
4
 0.73
chr16_10671409_10671697 0.05 RP11-27M24.2
487
 0.78
chr2_240230661_240230844 0.05 HDAC4
 histone deacetylase 4
 155
 0.95
chr12_91575790_91576058 0.05 DCN
 decorin
 505
 0.87
chr6_127839583_127839785 0.05 SOGA3
 SOGA family member 3
 352
 0.91
chr1_174081654_174081874 0.05 RABGAP1L
 RAB GTPase activating protein 1-like
 46784
 0.14
chr10_80009045_80009196 0.05 ENSG00000201393
 .
 118144
 0.06
chr15_40269217_40269368 0.05 EIF2AK4
 eukaryotic translation initiation factor 2 alpha kinase 4
 23116
 0.14
chr16_121633_122294 0.05 RHBDF1
 rhomboid 5 homolog 1 (Drosophila)
 666
 0.51
chr8_37556330_37556485 0.05 ZNF703
 zinc finger protein 703
 3138
 0.17
chr3_100852493_100852644 0.05 ENSG00000238312
 .
 68108
 0.12
chr9_97682991_97683218 0.05 RP11-54O15.3
14124
 0.17
chr6_113885726_113885909 0.05 ENSG00000266650
 .
 38300
 0.18
chr17_80970638_80970845 0.05 RP11-1197K16.2
31783
 0.15
chr8_124829147_124829427 0.05 FER1L6
 fer-1-like 6 (C. elegans)
 34940
 0.17
chr11_125365710_125366094 0.05 FEZ1
 fasciculation and elongation protein zeta 1 (zygin I)
 116
 0.91
chr11_121593168_121593875 0.05 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 132393
 0.05
chr8_18941319_18941572 0.05 PSD3
 pleckstrin and Sec7 domain containing 3
 795
 0.76
chr5_34487804_34487985 0.05 RAI14
 retinoic acid induced 14
 168448
 0.03
chr4_177712658_177713139 0.05 VEGFC
 vascular endothelial growth factor C
 983
 0.71
chr7_30952459_30952610 0.05 AQP1
 aquaporin 1 (Colton blood group)
 1064
 0.6
chr7_19136961_19137112 0.05 AC003986.6
15061
 0.16
chr5_150283969_150284454 0.05 ZNF300
 zinc finger protein 300
 140
 0.96
chr10_17241830_17242242 0.05 TRDMT1
 tRNA aspartic acid methyltransferase 1
 1543
 0.37
chr11_75272983_75274329 0.05 SERPINH1
 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
 216
 0.91
chr3_73652541_73652692 0.05 ENSG00000239119
 .
 9463
 0.21
chr3_189306684_189306989 0.05 TP63
 tumor protein p63
 42380
 0.21
chr5_171839559_171839710 0.05 ENSG00000216127
 .
 27124
 0.19
chr18_46020104_46020474 0.05 ENSG00000200872
 .
 18318
 0.21
chr1_34630860_34631011 0.05 CSMD2
 CUB and Sushi multiple domains 2
 60
 0.96
chr5_159305990_159306237 0.05 ADRA1B
 adrenoceptor alpha 1B
 37677
 0.2
chr18_56532811_56532962 0.05 ZNF532
 zinc finger protein 532
 100
 0.97
chr12_309110_309261 0.05 RP11-283I3.2
3623
 0.16
chr1_86859564_86859715 0.05 ODF2L
 outer dense fiber of sperm tails 2-like
 2021
 0.38
chrY_14075891_14076042 0.05 ENSG00000265161
 .
 128454
 0.06
chr8_87052179_87052395 0.05 PSKH2
 protein serine kinase H2
 29639
 0.19
chr1_173835540_173835691 0.05 ENSG00000234741
 .
 106
 0.88
chr22_25348691_25349626 0.05 KIAA1671
 KIAA1671
 461
 0.83
chr5_86478454_86478741 0.05 AC008394.1
 Uncharacterized protein
 56225
 0.12
chr18_12745437_12745588 0.05 ENSG00000201466
 .
 15204
 0.16
chr21_35133624_35133954 0.05 ITSN1
 intersectin 1 (SH3 domain protein)
 26443
 0.2
chr10_74544262_74544615 0.05 RP11-354E23.5
18120
 0.19
chr2_134325508_134325697 0.05 NCKAP5
 NCK-associated protein 5
 429
 0.88
chrX_90690422_90690847 0.05 PABPC5-AS1
 PABPC5 antisense RNA 1
 636
 0.54
chr10_3290980_3291169 0.05 PITRM1
 pitrilysin metallopeptidase 1
 76071
 0.11
chr4_111397420_111397787 0.05 ENPEP
 glutamyl aminopeptidase (aminopeptidase A)
 374
 0.89
chr7_3299969_3300120 0.05 SDK1
 sidekick cell adhesion molecule 1
 41036
 0.16
chr13_109740818_109740969 0.05 MYO16-AS2
 MYO16 antisense RNA 2
 13374
 0.3
chr8_71359441_71359951 0.05 ENSG00000253143
 .
 33026
 0.17
chr6_83073574_83074143 0.05 TPBG
 trophoblast glycoprotein
 103
 0.98
chr12_8012330_8012481 0.05 ENSG00000201663
 .
 8991
 0.12
chr18_59560344_59560906 0.05 RNF152
 ring finger protein 152
 367
 0.93
chr4_4862278_4863048 0.05 MSX1
 msh homeobox 1
 1270
 0.58
chr4_39525757_39525928 0.05 UGDH
 UDP-glucose 6-dehydrogenase
 2335
 0.24
chr10_52833938_52834229 0.05 PRKG1
 protein kinase, cGMP-dependent, type I
 149
 0.97
chr5_169230726_169230933 0.05 CTB-37A13.1
24460
 0.22
chr7_555957_556150 0.05 PDGFA
 platelet-derived growth factor alpha polypeptide
 2092
 0.33
chr11_101453394_101453891 0.05 TRPC6
 transient receptor potential cation channel, subfamily C, member 6
 592
 0.84
chr1_214722280_214722431 0.05 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 2211
 0.42
chr8_39966106_39966460 0.05 C8orf4
 chromosome 8 open reading frame 4
 44706
 0.18
chr3_114477226_114477377 0.05 ZBTB20
 zinc finger and BTB domain containing 20
 486
 0.86
chr17_1081882_1082496 0.05 ABR
 active BCR-related
 889
 0.58
chr5_150181131_150181300 0.05 AC010441.1
23348
 0.14

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of OTX2_CRX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0035588 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.1 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.0 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.0 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.0 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.0 GO:1902170 cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0 0.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.0 GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.0 GO:0018995 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.0 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0001228 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME PI 3K CASCADE Genes involved in PI-3K cascade
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation